Please see the GBrowse view of Dmel\Cdk8 or the JBrowse view of Dmel\Cdk8 for information on other features
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Gene model reviewed during 5.44
Gene model reviewed during 5.45
Gene model reviewed during 5.55
There is only one protein coding transcript and one polypeptide associated with this gene
Component of the Cdk8 module of the Mediator complex, composed of CycC, Cdk8, kto and skd.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cdk8 using the Feature Mapper tool.
Comment: maternally deposited
GBrowse - Visual display of RNA-Seq signals
View Dmel\Cdk8 in GBrowse 23-31
3-31
3-24.2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Source for identity of: Cdk8 CG10572
dsRNA has been made from templates generated with primers directed against this gene.
When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of S phase cells seen. The proportion of G2/M phase cells is equal to proportion of G1 phase cells.
Transcriptionally downregulated after 2h of insulin stimulation in Kc167 cells. Contains fkh response elements (FHREs) in the genomic upstream or intronic sequences.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in S2R+ cells: cell size is increased, microtubules are uniform or disorganised, cell shape is irregular, and cell number is decreased indicative of a failure in cell cycle progression through G1 to S and G2 to M stages. This phenotype is not seen in Kc167 cells.
Interacts in vitro and in vivo with CycC, also can interact in vivo with a large subunit RNA polymerase II.
