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Gene Dmel\Cdk8

General Information
Symbol	Dmel\Cdk8	Species	D. melanogaster
Name	Cyclin-dependent kinase 8	Annotation symbol	CG10572
Feature type	protein_coding_gene	FlyBase ID	FBgn0015618
Gene Model Status	Current	Stock availability	6 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	67C10-67C10	Sequence location	3L:9,830,185..9,831,750 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Cyclin-dependent kinase 8 is referred to in FlyBase by the symbol Dmel\Cdk8 (CG10572, FBgn0015618). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: cyclin-dependent protein kinase activity; RNA polymerase II transcription cofactor activity. There is experimental evidence that it is involved in the biological process: chaeta development; axon guidance; sex comb development; imaginal disc-derived leg segmentation; protein phosphorylation; mitotic cell cycle G2/M transition DNA damage checkpoint; cell cycle. 8 alleles are reported. The phenotype of these alleles is annotated with: mesothoracic tergum. It has one annotated transcript and one annotated polypeptide. Protein features are: Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine-protein kinase, active site; Serine/threonine-protein kinase, catalytic domain; Serine/threonine-protein kinase-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1630579_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Cdk8. Gene sequence location is 3L:9830185..9831750.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Transgenic Constructs P{Ubi-p63E-Cdk8.L}
FB2012_01	Controlled Vocabulary Terms imaginal disc-derived leg segmentation References Park et al., 2003, Molec. Cell. Biol. 23(4): 1358--1367 Sequence features BKN45143 HFA11113 BKN51376 BKN27735 BKN51316
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 67C10-67C10   Limits computationally determined from genome sequence between P{PZ}fry02240 and P{lacW}l(3)L0539L0539&P{PZ}Dhh1rL562
Experimentally Determined Cytological Location
Cytogenetic map Notes References 67C1-67C11     (Bennett, 1999.9.10)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Cdk8 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Cdk8-RA FBtr0076369  NM_080487   1504   454
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Cdk8-PA   FBpp0076098   53.7   454   8.87     NP_536735   AAF50197
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine-protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Serine/threonine-protein kinase-like domain (IPR017442)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF50197   AY119111 AAM50971   BI171541   BT099963   FE862772   FE862966   FE863105   FE863345   FE863412   U33015 AAB38385
UniProtKB/Swiss-Prot	Q9VT57
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0015618    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0015618 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0015618 expression level Developmental Stage   Expression Level embryo 00-02hr    1595 embryo 02-04hr    1568 embryo 04-06hr    2155 embryo 06-08hr    1185 embryo 08-10hr    800 embryo 10-12hr    633 embryo 12-14hr    379 embryo 14-16hr    298 embryo 16-18hr    234 embryo 18-20hr    214 embryo 20-22hr    145 embryo 22-24hr    183 larva L1    247 larva L2    268 larva L3 12hr old    225 larva L3 puffstage 1-2    334 larva L3 puffstage 3-6    440 larva L3 puffstage 7-9    521 white prepupae new    543 white prepupae 12hr    574 white prepupae 24hr    584 pupae 2d postWPP    439 pupae 3d postWPP    178 pupae 4d postWPP    141 adult male 01day    139 adult male 05day    159 adult male 30day    189 adult female 01day    474 adult female 05day    874 adult female 30day    869 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1595) embryo 02-04hr  (1568) embryo 04-06hr  (2155) embryo 06-08hr  (1185) embryo 08-10hr  (800) embryo 10-12hr  (633) embryo 12-14hr  (379) embryo 14-16hr  (298) embryo 16-18hr  (234) embryo 18-20hr  (214) embryo 20-22hr  (145) embryo 22-24hr  (183) larva L1  (247) larva L2  (268) larva L3 12hr old  (225) larva L3 puffstage 1-2  (334) larva L3 puffstage 3-6  (440) larva L3 puffstage 7-9  (521) white prepupae new  (543) white prepupae 12hr  (574) white prepupae 24hr  (584) pupae 2d postWPP  (439) pupae 3d postWPP  (178) pupae 4d postWPP  (141) adult male 01day  (139) adult male 05day  (159) adult male 30day  (189) adult female 01day  (474) adult female 05day  (874) adult female 30day  (869) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (1595) embryo 02-04hr  (1568) embryo 04-06hr  (2155) embryo 06-08hr    1185 embryo 08-10hr    800 embryo 10-12hr    633 embryo 12-14hr    379 embryo 14-16hr    298 embryo 16-18hr    234 embryo 18-20hr    214 embryo 20-22hr    145 embryo 22-24hr    183 larva L1    247 larva L2    268 larva L3 12hr old    225 larva L3 puffstage 1-2    334 larva L3 puffstage 3-6    440 larva L3 puffstage 7-9    521 white prepupae new    543 white prepupae 12hr    574 white prepupae 24hr    584 pupae 2d postWPP    439 pupae 3d postWPP    178 pupae 4d postWPP    141 adult male 01day    139 adult male 05day    159 adult male 30day    189 adult female 01day    474 adult female 05day    874 adult female 30day    869 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1595 embryo 02-04hr    1568 embryo 04-06hr    2155 embryo 06-08hr    1185 embryo 08-10hr    800 embryo 10-12hr    633 embryo 12-14hr    379 embryo 14-16hr    298 embryo 16-18hr    234 embryo 18-20hr    214 embryo 20-22hr    145 embryo 22-24hr    183 larva L1    247 larva L2    268 larva L3 12hr old    225 larva L3 puffstage 1-2    334 larva L3 puffstage 3-6    440 larva L3 puffstage 7-9    521 white prepupae new    543 white prepupae 12hr    574 white prepupae 24hr    584 pupae 2d postWPP    439 pupae 3d postWPP    178 pupae 4d postWPP    141 adult male 01day    139 adult male 05day    159 adult male 30day    189 adult female 01day    474 adult female 05day    874 adult female 30day    869 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1595 embryo 02-04hr    1568 embryo 04-06hr    2155 embryo 06-08hr    1185 embryo 08-10hr    800 embryo 10-12hr    633 embryo 12-14hr    379 embryo 14-16hr    298 embryo 16-18hr    234 embryo 18-20hr    214 embryo 20-22hr    145 embryo 22-24hr    183 larva L1    247 larva L2    268 larva L3 12hr old    225 larva L3 puffstage 1-2    334 larva L3 puffstage 3-6    440 larva L3 puffstage 7-9    521 white prepupae new    543 white prepupae 12hr    574 white prepupae 24hr    584 pupae 2d postWPP    439 pupae 3d postWPP    178 pupae 4d postWPP    141 adult male 01day    139 adult male 05day    159 adult male 30day    189 adult female 01day    474 adult female 05day    874 adult female 30day    869 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0015618 expression level Developmental Stage   Expression Level embryo 00-02hr    1595 embryo 02-04hr    1568 embryo 04-06hr    2155 embryo 06-08hr    1185 embryo 08-10hr    800 embryo 10-12hr    633 embryo 12-14hr    379 embryo 14-16hr    298 embryo 16-18hr    234 embryo 18-20hr    214 embryo 20-22hr    145 embryo 22-24hr    183 larva L1    247 larva L2    268 larva L3 12hr old    225 larva L3 puffstage 1-2    334 larva L3 puffstage 3-6    440 larva L3 puffstage 7-9    521 white prepupae new    543 white prepupae 12hr    574 white prepupae 24hr    584 pupae 2d postWPP    439 pupae 3d postWPP    178 pupae 4d postWPP    141 adult male 01day    139 adult male 05day    159 adult male 30day    189 adult female 01day    474 adult female 05day    874 adult female 30day    869 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1595) embryo 02-04hr  (1568) embryo 04-06hr  (2155) embryo 06-08hr  (1185) embryo 08-10hr  (800) embryo 10-12hr  (633) embryo 12-14hr  (379) embryo 14-16hr  (298) embryo 16-18hr  (234) embryo 18-20hr  (214) embryo 20-22hr  (145) embryo 22-24hr  (183) larva L1  (247) larva L2  (268) larva L3 12hr old  (225) larva L3 puffstage 1-2  (334) larva L3 puffstage 3-6  (440) larva L3 puffstage 7-9  (521) white prepupae new  (543) white prepupae 12hr  (574) white prepupae 24hr  (584) pupae 2d postWPP  (439) pupae 3d postWPP  (178) pupae 4d postWPP  141 adult male 01day  139 adult male 05day  (159) adult male 30day  (189) adult female 01day  (474) adult female 05day  (874) adult female 30day  (869) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1595 embryo 02-04hr  1568 embryo 04-06hr  2155 embryo 06-08hr    1185 embryo 08-10hr    800 embryo 10-12hr    633 embryo 12-14hr    379 embryo 14-16hr    298 embryo 16-18hr    234 embryo 18-20hr    214 embryo 20-22hr    145 embryo 22-24hr    183 larva L1    247 larva L2    268 larva L3 12hr old    225 larva L3 puffstage 1-2    334 larva L3 puffstage 3-6    440 larva L3 puffstage 7-9    521 white prepupae new    543 white prepupae 12hr    574 white prepupae 24hr    584 pupae 2d postWPP    439 pupae 3d postWPP    178 pupae 4d postWPP    141 adult male 01day    139 adult male 05day    159 adult male 30day    189 adult female 01day    474 adult female 05day    874 adult female 30day    869 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1595 embryo 02-04hr    1568 embryo 04-06hr    2155 embryo 06-08hr    1185 embryo 08-10hr    800 embryo 10-12hr    633 embryo 12-14hr    379 embryo 14-16hr    298 embryo 16-18hr    234 embryo 18-20hr    214 embryo 20-22hr    145 embryo 22-24hr    183 larva L1    247 larva L2    268 larva L3 12hr old    225 larva L3 puffstage 1-2    334 larva L3 puffstage 3-6    440 larva L3 puffstage 7-9    521 white prepupae new    543 white prepupae 12hr    574 white prepupae 24hr    584 pupae 2d postWPP    439 pupae 3d postWPP    178 pupae 4d postWPP    141 adult male 01day    139 adult male 05day    159 adult male 30day    189 adult female 01day    474 adult female 05day    874 adult female 30day    869 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1595 embryo 02-04hr    1568 embryo 04-06hr    2155 embryo 06-08hr    1185 embryo 08-10hr    800 embryo 10-12hr    633 embryo 12-14hr    379 embryo 14-16hr    298 embryo 16-18hr    234 embryo 18-20hr    214 embryo 20-22hr    145 embryo 22-24hr    183 larva L1    247 larva L2    268 larva L3 12hr old    225 larva L3 puffstage 1-2    334 larva L3 puffstage 3-6    440 larva L3 puffstage 7-9    521 white prepupae new    543 white prepupae 12hr    574 white prepupae 24hr    584 pupae 2d postWPP    439 pupae 3d postWPP    178 pupae 4d postWPP    141 adult male 01day    139 adult male 05day    159 adult male 30day    189 adult female 01day    474 adult female 05day    874 adult female 30day    869 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0015618    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0015618 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0015618 expression level Tissue   Expression Level Larval Central Nervous System    104.1 Larval Midgut    38.5 Larval Hindgut    39.2 Larval Malpighian Tubules    63.8 Larval Fat Body    45 Larval Salivary Gland    55.5 Larval Trachea    61.4 Larval Carcass    46.45 Adult Head    31.1 Adult Eye    39.025 Adult Brain    50.8 Adult Thoracic-Abdominal Ganglion    39.4 Adult Crop    48.2 Adult Midgut    36.8 Adult Hindgut    36.5 Adult Malpighian Tubules    29.9 Adult Fat Body no informative data Adult Salivary Gland    52.1 Adult Heart    24.2 Adult VirginFemale Spermatheca    41.6 Adult InseminatedFemale Spermatheca    40.7 Adult Ovary    136.4 Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    104.1 Larval Midgut    38.5 Larval Hindgut    39.2 Larval Malpighian Tubules    63.8 Larval Fat Body    45 Larval Salivary Gland    55.5 Larval Trachea    61.4 Larval Carcass    46.45 Adult Head    31.1 Adult Eye    39.025 Adult Brain    50.8 Adult Thoracic-Abdominal Ganglion    39.4 Adult Crop    48.2 Adult Midgut    36.8 Adult Hindgut    36.5 Adult Malpighian Tubules    29.9 Adult Fat Body no informative data Adult Salivary Gland    52.1 Adult Heart    24.2 Adult VirginFemale Spermatheca    41.6 Adult InseminatedFemale Spermatheca    40.7 Adult Ovary    136.4 Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    104.1 Larval Midgut    38.5 Larval Hindgut    39.2 Larval Malpighian Tubules    63.8 Larval Fat Body    45 Larval Salivary Gland    55.5 Larval Trachea    61.4 Larval Carcass    46.45 Adult Head    31.1 Adult Eye    39.025 Adult Brain    50.8 Adult Thoracic-Abdominal Ganglion    39.4 Adult Crop    48.2 Adult Midgut    36.8 Adult Hindgut    36.5 Adult Malpighian Tubules    29.9 Adult Fat Body no informative data Adult Salivary Gland    52.1 Adult Heart    24.2 Adult VirginFemale Spermatheca    41.6 Adult InseminatedFemale Spermatheca    40.7 Adult Ovary    136.4 Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    104.1 Larval Midgut    38.5 Larval Hindgut    39.2 Larval Malpighian Tubules    63.8 Larval Fat Body    45 Larval Salivary Gland    55.5 Larval Trachea    61.4 Larval Carcass    46.45 Adult Head    31.1 Adult Eye    39.025 Adult Brain    50.8 Adult Thoracic-Abdominal Ganglion    39.4 Adult Crop    48.2 Adult Midgut    36.8 Adult Hindgut    36.5 Adult Malpighian Tubules    29.9 Adult Fat Body no informative data Adult Salivary Gland    52.1 Adult Heart    24.2 Adult VirginFemale Spermatheca    41.6 Adult InseminatedFemale Spermatheca    40.7 Adult Ovary    136.4 Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0015618 expression level Tissue   Expression Level Larval Central Nervous System    104.1 Larval Midgut    38.5 Larval Hindgut    39.2 Larval Malpighian Tubules    63.8 Larval Fat Body    45 Larval Salivary Gland    55.5 Larval Trachea    61.4 Larval Carcass    46.45 Adult Head    31.1 Adult Eye    39.025 Adult Brain    50.8 Adult Thoracic-Abdominal Ganglion    39.4 Adult Crop    48.2 Adult Midgut    36.8 Adult Hindgut    36.5 Adult Malpighian Tubules    29.9 Adult Fat Body no informative data Adult Salivary Gland    52.1 Adult Heart    24.2 Adult VirginFemale Spermatheca    41.6 Adult InseminatedFemale Spermatheca    40.7 Adult Ovary    136.4 Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    104.1 Larval Midgut    38.5 Larval Hindgut    39.2 Larval Malpighian Tubules    63.8 Larval Fat Body    45 Larval Salivary Gland    55.5 Larval Trachea    61.4 Larval Carcass    46.45 Adult Head    31.1 Adult Eye    39.025 Adult Brain    50.8 Adult Thoracic-Abdominal Ganglion    39.4 Adult Crop    48.2 Adult Midgut    36.8 Adult Hindgut    36.5 Adult Malpighian Tubules    29.9 Adult Fat Body no informative data Adult Salivary Gland    52.1 Adult Heart    24.2 Adult VirginFemale Spermatheca    41.6 Adult InseminatedFemale Spermatheca    40.7 Adult Ovary    136.4 Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    104.1 Larval Midgut    38.5 Larval Hindgut    39.2 Larval Malpighian Tubules    63.8 Larval Fat Body    45 Larval Salivary Gland    55.5 Larval Trachea    61.4 Larval Carcass    46.45 Adult Head    31.1 Adult Eye    39.025 Adult Brain    50.8 Adult Thoracic-Abdominal Ganglion    39.4 Adult Crop    48.2 Adult Midgut    36.8 Adult Hindgut    36.5 Adult Malpighian Tubules    29.9 Adult Fat Body no informative data Adult Salivary Gland    52.1 Adult Heart    24.2 Adult VirginFemale Spermatheca    41.6 Adult InseminatedFemale Spermatheca    40.7 Adult Ovary    136.4 Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    104.1 Larval Midgut    38.5 Larval Hindgut    39.2 Larval Malpighian Tubules    63.8 Larval Fat Body    45 Larval Salivary Gland    55.5 Larval Trachea    61.4 Larval Carcass    46.45 Adult Head    31.1 Adult Eye    39.025 Adult Brain    50.8 Adult Thoracic-Abdominal Ganglion    39.4 Adult Crop    48.2 Adult Midgut    36.8 Adult Hindgut    36.5 Adult Malpighian Tubules    29.9 Adult Fat Body no informative data Adult Salivary Gland    52.1 Adult Heart    24.2 Adult VirginFemale Spermatheca    41.6 Adult InseminatedFemale Spermatheca    40.7 Adult Ovary    136.4 Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body no informative data Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    31.1   NA  Eye    39.025   NA  Brain    50.8   104.1  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    39.4   NA  Crop    48.2   38.5  Midgut    36.8   39.2  Hindgut    36.5   63.8  Malpighian Tubules    29.9   45  Fat Body    no informative data   55.5  Salivary Gland    52.1   NA  Heart    24.2   61.4  Trachea    NA   NA  VirginFemale Spermatheca    41.6   NA  InseminatedFemale Spermatheca    40.7   NA  Ovary    136.4   NA  Testis    no informative data   NA  Male Accessory Gland    no informative data   46.45  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_06
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015618 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10572-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | late third instar larval stage (with Df(3L)AC1) Cdk8K185 lethal | late third instar larval stage | recessive Cdk8K185 viable, with Scer\GAL4pnr-MD237 Cdk8GD7022 Other Phenotypes Allele neuroanatomy defective | somatic clone | third instar larval stage Cdk8H2480 visible, with Scer\GAL4pnr-MD237 Cdk8GD7022 Phenotype manifest in Allele leg | somatic clone - Minute background Cdk8K185 mesothoracic bristle | somatic clone Cdk8K185 mesothoracic bristle | somatic clone - Minute background Cdk8K185 mesothoracic tergum, with Scer\GAL4pnr-MD237 Cdk8GD7022 prothoracic tarsal segment | somatic clone Cdk8K185 sex comb tooth | somatic clone Cdk8K185
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of Cdk8 Class Mutagen Stocks Known lesion Cdk8A162 1 -- Cdk8K185 amorphic allele - molecular evidence, amorphic allele - genetic evidence Delta2-3 0 Yes Cdk8H2480 ethyl methanesulfonate 0 Yes
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Cdk8 Class Mutagen Stocks Known lesion Cdk8GD7022 in vitro construct - RNAi in vitro construct - regulatory fusion 3 Yes Cdk8GL00231 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Cdk8KK107735 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Cdk8GMR.PB in vitro construct - regulatory fusion 0 Yes Cdk8Ubi-p63E.PL in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)AC1 (Loncle et al., 2007) Df(3L)Cdk8K145 (Loncle et al., 2007)
Partially disrupted in	Df(3L)Cdk8K185 (Loncle et al., 2007)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7022} NA P{KK107735} NA P{TRiP.GL00231} NA characterization construct P{GMR-Cdk8.B} NA P{Ubi-p63E-Cdk8.L} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{?EP}I-2GE26681 NA PBac{5HPw+}Cdk8A162 NA
Gene Ontology: Function, Process & Cellular Component ( 14 unique terms )
Terms Based on Experimental Evidence ( 9 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
axon guidance inferred from mutant phenotype (Berger et al., 2008) cell cycle inferred from mutant phenotype (Kiger et al., 2003) chaeta development inferred from mutant phenotype (Loncle et al., 2007) imaginal disc-derived leg segmentation inferred from mutant phenotype (Loncle et al., 2007) mitotic cell cycle G2/M transition DNA damage checkpoint inferred from genetic interaction with nbs (Kondo and Perrimon, 2011) protein phosphorylation inferred from direct assay (assigned by UniProtKB) (Leclerc et al., 1996) sex comb development inferred from mutant phenotype (Loncle et al., 2007)
Cellular Component
CV term Evidence References
mediator complex inferred from direct assay (Park et al., 2003) inferred from physical interaction with CycC, kto, skd (Loncle et al., 2007) nucleus inferred from direct assay (Park et al., 2003) inferred from direct assay (assigned by UniProtKB) (Leclerc et al., 1996)
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR017441 (FlyBase Curators et al., 2004-) cyclin-dependent protein kinase activity inferred from sequence or structural similarity with UniProtKB:P39073 (FlyBase, 1992-) protein serine/threonine kinase activity non-traceable author statement (Leopold et al., 1996, Morrison et al., 2000) RNA polymerase II transcription cofactor activity inferred from sequence or structural similarity (Boube et al., 2000)
Biological Process
CV term Evidence References
protein phosphorylation non-traceable author statement (Morrison et al., 2000) transcription initiation from RNA polymerase II promoter inferred from sequence or structural similarity (Boube et al., 2000)
Cellular Component
CV term Evidence References
mediator complex inferred from sequence or structural similarity (Boube et al., 2000)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Cdk8 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64544 DroID - A comprehensive database of gene and protein interactions. • FBgn0015618 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39157
Orthologs
Genome-wide drosophilid orthologs	Dana\GF10227 Dere\GG14001 Dgri\GH22186 Dmoj\GI11413 Dper\GL20758 Dpse\GA28311 Dsec\GM24836 Dsim\GD12888 Dvir\GJ13608 Dwil\GK12315 Dyak\GE20297
Curated drosophilid orthologs
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL002395-PA Aedes aegypti (mosquito) AGAP009936-PA Anopheles gambiae (mosquito) XP_001950232.1 Acyrthosiphon pisum (pea aphid) At5g63610.1 Arabidopsis thaliana (wall cress) 13213 Batrachochytrium dendrobatidis (chytrid fungus) 174614 Branchiostoma floridae (lancelet) BGIBMGA011562-PA Bombyx mori (silk worm) ENSBTAP00000022252 Bos taurus (bovine) CAL0002024 Candida albicans (a form of yeast) CBP27381 Caenorhabditis briggsae (nematode) CE32409 Caenorhabditis elegans (worm) ENSCAFP00000010245 Canis familiaris (dog) CAGL0L12650g Candida glabrata (haploid yeast) JA07053 Caenorhabditis japonica (nematode) cn13084 Cryptococcus neoformans (yeast-like fungus) CPIJ000891 Culex pipens (mosquito) ENSCPOP00000011406 Cavia porcellus (guinea pig) 120881 Chlamidomonas reinhardtii (green alga) RP32022 Caenorhabditis remanei (nematode) ENSCSAVP00000000719 Ciona savignyi (sedentary tunicate) 224421 Capitella spl (polychaete worm) DDB0191261 Dictyostelium discoideum (amoeba) DEHA2F08844g Debaryomyces Hansenii (yeast) 204007 Daphnia pulex (daphnia) ENSDARP00000022588 Danio rerio (zebra fish) ENSECAP00000013399 Equus caballus (horse) ENSGACP00000004137 Gymnopilus aculeatus (mushroom) ENSGALP00000027576 Gallus gallus (chicken) 83659 Hypsipyla robusta (cedar shoot borer) ENSP00000370938 Homo sapiens (human) ISCW018877-PA Ixodes scapularis (deer tick) KLLA0D11814g Kluyveromyces lactis (yeast) 210630 Lottia gigantea (owl limpet) 33116 Monocosta brevicollis (choanoflagellate) ENSMODP00000010892 Monodelphis domestica (gray opossum) ENSMMUP00000019486 Macaca mulatta (rhesus monkey) ENSMUSP00000031640 Mus musculus (house mouse) 11543 Nematostella vectensis (starlet anemone) XP_001599544.1 Nasonia vitripennis (wasp) ENSOANP00000014405 Ornithorynchus anatinus (platypus) ENSORLP00000011144 Oryzias latipes (japanese killifish) ENSORLP00000019100 Oryzias latipes (japanese killifish) LOC_Os10g42950.1 Oryza sativa (asian rice) 20354 Ostreococcus tauri (green alga) PHUM003812-PA Pediculus humanus (human body louse) PP16874 Pristionchus pacificus (nematode) 184162 Physcomitrella patens (moss) ENSPPYP00000005956 Pongo pygmaeus (orangutan) 52262 Phytophthora ramorum (sudden oak death pathogen) 119398 Phytophthora sojae (root rot pathogen) 640317 Populus trichocarpa (black cottonwood) ENSPTRP00000009752 Pan troglodytes (chimpanzee) ENSRNOP00000000713 Rattus norvegicus (norway rat) 4869815 Sorghum bicolor (sorghum) YPL042C Saccharomyces cerevisiae (budding yeast) Smp_156990 Schistosoma mansoni (trematode parasite) SPAC23H4.17c Schizosaccharomyces pombe (fission yeast) XP_001191826.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001201474.1 Strongylocentrotus purpuratus (purple sea urchin) 32711 Trichoplax adhaerens (metazoa) XP_971782.1 Tribolium castaneum (red flour beetle) ENSTNIP00000015691 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000009402 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000046130 Xenopus tropicalis (frog) YALI0C10967g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17787 NV17938 LH23083 ISCW018877 FBgn0237616 FBgn0214325 FBgn0200830 FBgn0184613 FBgn0179698 FBgn0249673 JGI_V11_204007 JGI_V11_73263 FBgn0158353 FBgn0134174 FBgn0129647 FBgn0124470 FBgn0106263 FBgn0087268 CPIJ000891 BGIBMGA011562 ACYPI009537 AGAP009936 CDK8_AEDAE PHUM298010 GLEAN_04891
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	35324 y1 sc* v1; P{TRiP.GL00231}attP2 16058 y1 w1118; PBac{5HPw+}Cdk8A162
VDRC	v107187 P{KK107735}VIE-260B v45371 w1118 P{GD7022}v45371 v31264 w1118; P{GD7022}v31264 v45370 w1118; P{GD7022}v45370
Genomic Clones ( 2 )
	BACR07A05 BACR07E07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 7 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE13344
Other clones	FI03233
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	RM06692 RM06792 RM06992 RM07192 RM07292
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0015618 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39157
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Cdk8 CG10572 (Li, 1999.11)
Source for database merge of
Additional comments
Other Comments
	dsRNA has been made from templates generated with primers directed against this gene. (Marr et al., 2006) When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of S phase cells seen. The proportion of G2/M phase cells is equal to proportion of G1 phase cells. (Bettencourt-Dias et al., 2004) Transcriptionally downregulated after 2h of insulin stimulation in Kc167 cells. Contains fkh response elements (FHREs) in the genomic upstream or intronic sequences. (Junger et al., 2003) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in S2R+ cells: cell size is increased, microtubules are uniform or disorganised, cell shape is irregular, and cell number is decreased indicative of a failure in cell cycle progression through G1 to S and G2 to M stages. This phenotype is not seen in Kc167 cells. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Cdk8 protein interacts in vivo with CycC protein and also with RpII215 protein. (Leclerc et al., 1996) Interacts in vitro and in vivo with CycC, also can interact in vivo with a large subunit RNA polymerase II. (Leopold et al., 1996)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080487 RefSeq (Proteins) • NP_536735 DDBJ / EMBL / GenBank • AAB38385 AAF50197 AAM50971 AJ249461 AY119111 BI171541 U33015 Entrez Gene - A searchable database of RefSeq genes. • 39157 UniProtKB/Swiss-Prot • Q9VT57
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine-protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Serine/threonine-protein kinase-like domain (IPR017442)
Linkouts
	BioGRID - A database of protein and genetic interactions • 64544 DroID - A comprehensive database of gene and protein interactions. • FBgn0015618 DRSC - Results from RNAi screens. • FBgn0015618 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015618 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10572-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0015618 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39157 InParanoid A subset of ortholog calls from InParanoid. • AAEL002395-PA Aedes aegypti (mosquito) AGAP009936-PA Anopheles gambiae (mosquito) XP_001950232.1 Acyrthosiphon pisum (pea aphid) At5g63610.1 Arabidopsis thaliana (wall cress) 13213 Batrachochytrium dendrobatidis (chytrid fungus) 174614 Branchiostoma floridae (lancelet) BGIBMGA011562-PA Bombyx mori (silk worm) ENSBTAP00000022252 Bos taurus (bovine) CAL0002024 Candida albicans (a form of yeast) CBP27381 Caenorhabditis briggsae (nematode) CE32409 Caenorhabditis elegans (worm) ENSCAFP00000010245 Canis familiaris (dog) CAGL0L12650g Candida glabrata (haploid yeast) JA07053 Caenorhabditis japonica (nematode) cn13084 Cryptococcus neoformans (yeast-like fungus) CPIJ000891 Culex pipens (mosquito) ENSCPOP00000011406 Cavia porcellus (guinea pig) 120881 Chlamidomonas reinhardtii (green alga) RP32022 Caenorhabditis remanei (nematode) ENSCSAVP00000000719 Ciona savignyi (sedentary tunicate) 224421 Capitella spl (polychaete worm) DDB0191261 Dictyostelium discoideum (amoeba) DEHA2F08844g Debaryomyces Hansenii (yeast) 204007 Daphnia pulex (daphnia) ENSDARP00000022588 Danio rerio (zebra fish) ENSECAP00000013399 Equus caballus (horse) ENSGACP00000004137 Gymnopilus aculeatus (mushroom) ENSGALP00000027576 Gallus gallus (chicken) 83659 Hypsipyla robusta (cedar shoot borer) ENSP00000370938 Homo sapiens (human) ISCW018877-PA Ixodes scapularis (deer tick) KLLA0D11814g Kluyveromyces lactis (yeast) 210630 Lottia gigantea (owl limpet) 33116 Monocosta brevicollis (choanoflagellate) ENSMODP00000010892 Monodelphis domestica (gray opossum) ENSMMUP00000019486 Macaca mulatta (rhesus monkey) ENSMUSP00000031640 Mus musculus (house mouse) 11543 Nematostella vectensis (starlet anemone) XP_001599544.1 Nasonia vitripennis (wasp) ENSOANP00000014405 Ornithorynchus anatinus (platypus) ENSORLP00000011144 Oryzias latipes (japanese killifish) ENSORLP00000019100 Oryzias latipes (japanese killifish) LOC_Os10g42950.1 Oryza sativa (asian rice) 20354 Ostreococcus tauri (green alga) PHUM003812-PA Pediculus humanus (human body louse) PP16874 Pristionchus pacificus (nematode) 184162 Physcomitrella patens (moss) ENSPPYP00000005956 Pongo pygmaeus (orangutan) 52262 Phytophthora ramorum (sudden oak death pathogen) 119398 Phytophthora sojae (root rot pathogen) 640317 Populus trichocarpa (black cottonwood) ENSPTRP00000009752 Pan troglodytes (chimpanzee) ENSRNOP00000000713 Rattus norvegicus (norway rat) 4869815 Sorghum bicolor (sorghum) YPL042C Saccharomyces cerevisiae (budding yeast) Smp_156990 Schistosoma mansoni (trematode parasite) SPAC23H4.17c Schizosaccharomyces pombe (fission yeast) XP_001191826.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001201474.1 Strongylocentrotus purpuratus (purple sea urchin) 32711 Trichoplax adhaerens (metazoa) XP_971782.1 Tribolium castaneum (red flour beetle) ENSTNIP00000015691 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000009402 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000046130 Xenopus tropicalis (frog) YALI0C10967g Yarrowia lipolytica (nonconventional yeast) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/cdk8.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39157 modMine - Data generated by the modENCODE project. • FBgn0015618 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17787 NV17938 LH23083 ISCW018877 FBgn0237616 FBgn0214325 FBgn0200830 FBgn0184613 FBgn0179698 FBgn0249673 JGI_V11_204007 JGI_V11_73263 FBgn0158353 FBgn0134174 FBgn0129647 FBgn0124470 FBgn0106263 FBgn0087268 CPIJ000891 BGIBMGA011562 ACYPI009537 AGAP009936 CDK8_AEDAE PHUM298010 GLEAN_04891
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	Cdk8 (Wang et al., 2008, Ji et al., 2007, Marr et al., 2006, Kim and Lis, 2005, Garcia et al., 2007, Guglielmi et al., 2004, Levine and Tjian, 2003, de Ayala Alonso et al., 2007, Loncle et al., 2007, Raynaud-Messina et al., 2004, Gim et al., 2001, Berger et al., 2008, Gobert et al., 2010) cdk8 (Brumby et al., 2004, Carrera et al., 2008, Berger et al., 2008) CDK8 (Bourbon et al., 2004, Boube et al., 2000, Kondo and Perrimon, 2011) CG10572 (Morrison et al., 2000, Boube et al., 2000, Keleman et al., 2009.8.5, Berger et al., 2008, Ni et al., 2011.7.19) DmCdk8 (Leclerc et al., 1996) dTRAP56 (Boube et al., 2000) p58 (Park et al., 2001)
Name Synonym	Cyclin-dependent kinase 8 (Leopold et al., 1996)
Secondary FlyBase IDs
References ( 45 )
Generate a list of	All references relating to this gene ( 45 )
List References by type	Research paper  ( 22 ) Supplementary material  ( 4 ) Review  ( 2 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 3 ) FlyBase analysis  ( 1 ) Letter  ( 1 ) Conference report  ( 1 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 2 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 2 )
	Kondo and Perrimon, 2011, Sci. Signal. 4(154): rs1 A Genome-Wide RNAi Screen Identifies Core Components of the G2-M DNA Damage Checkpoint. [FBrf0212700] Gobert et al., 2010, Mol. Cell. Biol. 30(11): 2837--2848 A genome-wide RNA interference screen identifies a differential role of the mediator CDK8 module subunits for GATA/ RUNX-activated transcription in drosophila. [FBrf0210768] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...