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Gene Dmel\Cdk8

General Information
Symbol	Dmel\Cdk8	Species	D. melanogaster
Name	Cyclin-dependent kinase 8	Annotation symbol	CG10572
Feature type	protein_coding_gene	FlyBase ID	FBgn0015618
Gene Model Status	Current	Stock availability	7 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	67C10-67C10	Sequence location	3L:9,830,180..9,831,791 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Cyclin-dependent kinase 8 is referred to in FlyBase by the symbol Dmel\Cdk8 (CG10572, FBgn0015618). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: cyclin-dependent protein serine/threonine kinase activity; RNA polymerase II transcription cofactor activity. There is experimental evidence that it is involved in the biological process: chaeta development; axon guidance; sex comb development; imaginal disc-derived leg segmentation; protein phosphorylation; mitotic G2 DNA damage checkpoint; cell cycle. 10 alleles are reported. The phenotype of these alleles is annotated with: mesothoracic tergum. It has one annotated transcript and one annotated polypeptide. Protein features are: Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine- / dual specificity protein kinase, catalytic domain; Serine/threonine-protein kinase, active site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1630579_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Cdk8. Gene sequence location is 3L:9830180..9831791.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03	Alleles Cdk8[c01804]
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 67C10-67C10   Limits computationally determined from genome sequence between P{PZ}fry02240 and P{lacW}l(3)L0539L0539&P{PZ}Dhh1rL562
Experimentally Determined Cytological Location
Cytogenetic map Notes References 67C1-67C11     (Bennett, 1999.9.10)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Cdk8 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.44 Gene model reviewed during 5.45
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Cdk8-RA FBtr0076369  NM_080487   1550   454
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Cdk8-PA   FBpp0076098   53.7   454   8.87     NP_536735   AAF50197
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine- / dual specificity protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF50197   AY119111 AAM50971   BI171541   BT099963   FE862772   FE862966   FE863105   FE863345   FE863412   U33015 AAB38385
UniProtKB/Swiss-Prot	Q9VT57
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   central brain primordium   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
mediator complex inferred from direct assay (Park et al., 2003) inferred from physical interaction with CycC, kto, skd (Loncle et al., 2007) nucleus inferred from direct assay (Park et al., 2003) inferred from direct assay (assigned by UniProtKB) (Leclerc et al., 1996)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    104.1 Larval Midgut    38.5 Larval Hindgut    39.2 Larval Malpighian Tubules    63.8 Larval Fat Body    45 Larval Salivary Gland    55.5 Larval Trachea    61.4 Larval Carcass    46.45 Adult Head    31.1 Adult Eye    39.025 Adult Brain    50.8 Adult Thoracic-Abdominal Ganglion    39.4 Adult Crop    48.2 Adult Midgut    36.8 Adult Hindgut    36.5 Adult Malpighian Tubules    29.9 Adult Fat Body    26.8 Adult Salivary Gland    52.1 Adult Heart    24.2 Adult VirginFemale Spermatheca    41.6 Adult InseminatedFemale Spermatheca    40.7 Adult Ovary    136.4 Adult Testis    11.7 Adult Male Accessory Gland    43.5 Adult Carcass    22.7 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    104.1 Larval Midgut    38.5 Larval Hindgut    39.2 Larval Malpighian Tubules    63.8 Larval Fat Body    45 Larval Salivary Gland    55.5 Larval Trachea    61.4 Larval Carcass    46.45 Adult Head    31.1 Adult Eye    39.025 Adult Brain    50.8 Adult Thoracic-Abdominal Ganglion    39.4 Adult Crop    48.2 Adult Midgut    36.8 Adult Hindgut    36.5 Adult Malpighian Tubules    29.9 Adult Fat Body    26.8 Adult Salivary Gland    52.1 Adult Heart    24.2 Adult VirginFemale Spermatheca    41.6 Adult InseminatedFemale Spermatheca    40.7 Adult Ovary    136.4 Adult Testis    11.7 Adult Male Accessory Gland    43.5 Adult Carcass    22.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    104.1 Larval Midgut    38.5 Larval Hindgut    39.2 Larval Malpighian Tubules    63.8 Larval Fat Body    45 Larval Salivary Gland    55.5 Larval Trachea    61.4 Larval Carcass    46.45 Adult Head    31.1 Adult Eye    39.025 Adult Brain    50.8 Adult Thoracic-Abdominal Ganglion    39.4 Adult Crop    48.2 Adult Midgut    36.8 Adult Hindgut    36.5 Adult Malpighian Tubules    29.9 Adult Fat Body    26.8 Adult Salivary Gland    52.1 Adult Heart    24.2 Adult VirginFemale Spermatheca    41.6 Adult InseminatedFemale Spermatheca    40.7 Adult Ovary    136.4 Adult Testis    11.7 Adult Male Accessory Gland    43.5 Adult Carcass    22.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    104.1 Larval Midgut    38.5 Larval Hindgut    39.2 Larval Malpighian Tubules    63.8 Larval Fat Body    45 Larval Salivary Gland    55.5 Larval Trachea    61.4 Larval Carcass    46.45 Adult Head    31.1 Adult Eye    39.025 Adult Brain    50.8 Adult Thoracic-Abdominal Ganglion    39.4 Adult Crop    48.2 Adult Midgut    36.8 Adult Hindgut    36.5 Adult Malpighian Tubules    29.9 Adult Fat Body    26.8 Adult Salivary Gland    52.1 Adult Heart    24.2 Adult VirginFemale Spermatheca    41.6 Adult InseminatedFemale Spermatheca    40.7 Adult Ovary    136.4 Adult Testis    11.7 Adult Male Accessory Gland    43.5 Adult Carcass    22.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    104.1 Larval Midgut    38.5 Larval Hindgut    39.2 Larval Malpighian Tubules    63.8 Larval Fat Body    45 Larval Salivary Gland    55.5 Larval Trachea    61.4 Larval Carcass    46.45 Adult Head    31.1 Adult Eye    39.025 Adult Brain    50.8 Adult Thoracic-Abdominal Ganglion    39.4 Adult Crop    48.2 Adult Midgut    36.8 Adult Hindgut    36.5 Adult Malpighian Tubules    29.9 Adult Fat Body    26.8 Adult Salivary Gland    52.1 Adult Heart    24.2 Adult VirginFemale Spermatheca    41.6 Adult InseminatedFemale Spermatheca    40.7 Adult Ovary    136.4 Adult Testis    11.7 Adult Male Accessory Gland    43.5 Adult Carcass    22.7 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    104.1 Larval Midgut    38.5 Larval Hindgut    39.2 Larval Malpighian Tubules    63.8 Larval Fat Body    45 Larval Salivary Gland    55.5 Larval Trachea    61.4 Larval Carcass    46.45 Adult Head    31.1 Adult Eye    39.025 Adult Brain    50.8 Adult Thoracic-Abdominal Ganglion    39.4 Adult Crop    48.2 Adult Midgut    36.8 Adult Hindgut    36.5 Adult Malpighian Tubules    29.9 Adult Fat Body    26.8 Adult Salivary Gland    52.1 Adult Heart    24.2 Adult VirginFemale Spermatheca    41.6 Adult InseminatedFemale Spermatheca    40.7 Adult Ovary    136.4 Adult Testis    11.7 Adult Male Accessory Gland    43.5 Adult Carcass    22.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    104.1 Larval Midgut    38.5 Larval Hindgut    39.2 Larval Malpighian Tubules    63.8 Larval Fat Body    45 Larval Salivary Gland    55.5 Larval Trachea    61.4 Larval Carcass    46.45 Adult Head    31.1 Adult Eye    39.025 Adult Brain    50.8 Adult Thoracic-Abdominal Ganglion    39.4 Adult Crop    48.2 Adult Midgut    36.8 Adult Hindgut    36.5 Adult Malpighian Tubules    29.9 Adult Fat Body    26.8 Adult Salivary Gland    52.1 Adult Heart    24.2 Adult VirginFemale Spermatheca    41.6 Adult InseminatedFemale Spermatheca    40.7 Adult Ovary    136.4 Adult Testis    11.7 Adult Male Accessory Gland    43.5 Adult Carcass    22.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    104.1 Larval Midgut    38.5 Larval Hindgut    39.2 Larval Malpighian Tubules    63.8 Larval Fat Body    45 Larval Salivary Gland    55.5 Larval Trachea    61.4 Larval Carcass    46.45 Adult Head    31.1 Adult Eye    39.025 Adult Brain    50.8 Adult Thoracic-Abdominal Ganglion    39.4 Adult Crop    48.2 Adult Midgut    36.8 Adult Hindgut    36.5 Adult Malpighian Tubules    29.9 Adult Fat Body    26.8 Adult Salivary Gland    52.1 Adult Heart    24.2 Adult VirginFemale Spermatheca    41.6 Adult InseminatedFemale Spermatheca    40.7 Adult Ovary    136.4 Adult Testis    11.7 Adult Male Accessory Gland    43.5 Adult Carcass    22.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    31.1   NA  Eye    39.025   NA  Brain    50.8   104.1  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    39.4   NA  Crop    48.2   38.5  Midgut    36.8   39.2  Hindgut    36.5   63.8  Malpighian Tubules    29.9   45  Fat Body    no informative data   55.5  Salivary Gland    52.1   NA  Heart    24.2   61.4  Trachea    NA   NA  VirginFemale Spermatheca    41.6   NA  InseminatedFemale Spermatheca    40.7   NA  Ovary    136.4   NA  Testis    no informative data   NA  Male Accessory Gland    no informative data   46.45  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    12 central nervous system, pupae P8    6 head, virgin 1-day female    1 head, virgin 4-day female    3 head, virgin 20-day female    1 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    3 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    2 carcass, larvae L3 wandering    8 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    17 ovary, mated 4-day female    18 testis, mated 4-day male    1 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    12 central nervous system, pupae P8    6 head, virgin 1-day female    1 head, virgin 4-day female    3 head, virgin 20-day female    1 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    3 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    2 carcass, larvae L3 wandering    8 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    17 ovary, mated 4-day female    18 testis, mated 4-day male    1 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    12 central nervous system, pupae P8    6 head, virgin 1-day female    1 head, virgin 4-day female    3 head, virgin 20-day female    1 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    3 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    2 carcass, larvae L3 wandering    8 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    17 ovary, mated 4-day female    18 testis, mated 4-day male    1 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    12 central nervous system, pupae P8    6 head, virgin 1-day female    1 head, virgin 4-day female    3 head, virgin 20-day female    1 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    3 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    2 carcass, larvae L3 wandering    8 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    17 ovary, mated 4-day female    18 testis, mated 4-day male    1 accessory gland, mated 4-day male    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    12 central nervous system, pupae P8    6 head, virgin 1-day female    1 head, virgin 4-day female    3 head, virgin 20-day female    1 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    3 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    2 carcass, larvae L3 wandering    8 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    17 ovary, mated 4-day female    18 testis, mated 4-day male    1 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    12 central nervous system, pupae P8    6 head, virgin 1-day female    1 head, virgin 4-day female    3 head, virgin 20-day female    1 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    3 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    2 carcass, larvae L3 wandering    8 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    17 ovary, mated 4-day female    18 testis, mated 4-day male    1 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    12 central nervous system, pupae P8    6 head, virgin 1-day female    1 head, virgin 4-day female    3 head, virgin 20-day female    1 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    3 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    2 carcass, larvae L3 wandering    8 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    17 ovary, mated 4-day female    18 testis, mated 4-day male    1 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    12 central nervous system, pupae P8    6 head, virgin 1-day female    1 head, virgin 4-day female    3 head, virgin 20-day female    1 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    3 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    2 carcass, larvae L3 wandering    8 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    17 ovary, mated 4-day female    18 testis, mated 4-day male    1 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    20 embryo 02-04hr    20 embryo 04-06hr    28 embryo 06-08hr    15 embryo 08-10hr    10 embryo 10-12hr    8 embryo 12-14hr    5 embryo 14-16hr    4 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    3 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    7 white prepupae 12hr    7 white prepupae 24hr    7 pupae 2d postWPP    6 pupae 3d postWPP    2 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    6 adult female 05day    11 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    20 embryo 02-04hr    20 embryo 04-06hr  (28) embryo 06-08hr    15 embryo 08-10hr    10 embryo 10-12hr    8 embryo 12-14hr    5 embryo 14-16hr    4 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    3 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    7 white prepupae 12hr    7 white prepupae 24hr    7 pupae 2d postWPP    6 pupae 3d postWPP    2 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    6 adult female 05day    11 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    20 embryo 02-04hr    20 embryo 04-06hr    28 embryo 06-08hr    15 embryo 08-10hr    10 embryo 10-12hr    8 embryo 12-14hr    5 embryo 14-16hr    4 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    3 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    7 white prepupae 12hr    7 white prepupae 24hr    7 pupae 2d postWPP    6 pupae 3d postWPP    2 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    6 adult female 05day    11 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    20 embryo 02-04hr    20 embryo 04-06hr    28 embryo 06-08hr    15 embryo 08-10hr    10 embryo 10-12hr    8 embryo 12-14hr    5 embryo 14-16hr    4 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    3 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    7 white prepupae 12hr    7 white prepupae 24hr    7 pupae 2d postWPP    6 pupae 3d postWPP    2 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    6 adult female 05day    11 adult female 30day    11 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    20 embryo 02-04hr    20 embryo 04-06hr    28 embryo 06-08hr    15 embryo 08-10hr    10 embryo 10-12hr    8 embryo 12-14hr    5 embryo 14-16hr    4 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    3 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    7 white prepupae 12hr    7 white prepupae 24hr    7 pupae 2d postWPP    6 pupae 3d postWPP    2 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    6 adult female 05day    11 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    20 embryo 02-04hr    20 embryo 04-06hr  28 embryo 06-08hr    15 embryo 08-10hr    10 embryo 10-12hr    8 embryo 12-14hr    5 embryo 14-16hr    4 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    3 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    7 white prepupae 12hr    7 white prepupae 24hr    7 pupae 2d postWPP    6 pupae 3d postWPP    2 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    6 adult female 05day    11 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    20 embryo 02-04hr    20 embryo 04-06hr    28 embryo 06-08hr    15 embryo 08-10hr    10 embryo 10-12hr    8 embryo 12-14hr    5 embryo 14-16hr    4 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    3 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    7 white prepupae 12hr    7 white prepupae 24hr    7 pupae 2d postWPP    6 pupae 3d postWPP    2 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    6 adult female 05day    11 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    20 embryo 02-04hr    20 embryo 04-06hr    28 embryo 06-08hr    15 embryo 08-10hr    10 embryo 10-12hr    8 embryo 12-14hr    5 embryo 14-16hr    4 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    3 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    7 white prepupae 12hr    7 white prepupae 24hr    7 pupae 2d postWPP    6 pupae 3d postWPP    2 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    6 adult female 05day    11 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    7 embryonic 1182-4H    10 embryonic GM2    4 embryonic Kc167    12 embryonic S1    7 embryonic S3    5 leg disc CME L1    9 wing disc CME-W2    8 wing disc ML-DmD8    6 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    8 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    7 ovary fGS/OSS    10 ovary OSC    10 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    7 embryonic 1182-4H    10 embryonic GM2    4 embryonic Kc167    12 embryonic S1    7 embryonic S3    5 leg disc CME L1    9 wing disc CME-W2    8 wing disc ML-DmD8    6 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    8 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    7 ovary fGS/OSS    10 ovary OSC    10 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    7 embryonic 1182-4H    10 embryonic GM2    4 embryonic Kc167    12 embryonic S1    7 embryonic S3    5 leg disc CME L1    9 wing disc CME-W2    8 wing disc ML-DmD8    6 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    8 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    7 ovary fGS/OSS    10 ovary OSC    10 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    7 embryonic 1182-4H    10 embryonic GM2    4 embryonic Kc167    12 embryonic S1    7 embryonic S3    5 leg disc CME L1    9 wing disc CME-W2    8 wing disc ML-DmD8    6 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    8 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    7 ovary fGS/OSS    10 ovary OSC    10 ovary OSS    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    7 embryonic 1182-4H    10 embryonic GM2    4 embryonic Kc167    12 embryonic S1    7 embryonic S3    5 leg disc CME L1    9 wing disc CME-W2    8 wing disc ML-DmD8    6 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    8 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    7 ovary fGS/OSS    10 ovary OSC    10 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    7 embryonic 1182-4H    10 embryonic GM2    4 embryonic Kc167    12 embryonic S1    7 embryonic S3    5 leg disc CME L1    9 wing disc CME-W2    8 wing disc ML-DmD8    6 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    8 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    7 ovary fGS/OSS    10 ovary OSC    10 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    7 embryonic 1182-4H    10 embryonic GM2    4 embryonic Kc167    12 embryonic S1    7 embryonic S3    5 leg disc CME L1    9 wing disc CME-W2    8 wing disc ML-DmD8    6 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    8 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    7 ovary fGS/OSS    10 ovary OSC    10 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    7 embryonic 1182-4H    10 embryonic GM2    4 embryonic Kc167    12 embryonic S1    7 embryonic S3    5 leg disc CME L1    9 wing disc CME-W2    8 wing disc ML-DmD8    6 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    8 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    7 ovary fGS/OSS    10 ovary OSC    10 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_06 mE1_20_mRNA_expression_cluster_06
External Data & Images
Linkouts	BDGP expression data • FI03233 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015618 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10572-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | late third instar larval stage (with Df(3L)AC1) Cdk8K185 lethal | late third instar larval stage | recessive Cdk8K185 viable, with Scer\GAL4pnr-MD237 Cdk8GD7022 Other Phenotypes Allele neuroanatomy defective | somatic clone | third instar larval stage Cdk8H2480 visible, with Scer\GAL4pnr-MD237 Cdk8GD7022 Phenotype manifest in Allele leg | somatic clone - Minute background Cdk8K185 mesothoracic bristle | somatic clone Cdk8K185 mesothoracic bristle | somatic clone - Minute background Cdk8K185 mesothoracic tergum, with Scer\GAL4pnr-MD237 Cdk8GD7022 prothoracic tarsal segment | somatic clone Cdk8K185 sex comb tooth | somatic clone Cdk8K185
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of Cdk8 Class Mutagen Stocks Known lesion Cdk8A162 1 -- Cdk8c01804 1 -- Cdk8K185 amorphic allele - molecular evidence, amorphic allele - genetic evidence Delta2-3 0 Yes Cdk8H2480 ethyl methanesulfonate 0 Yes
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Cdk8 Class Mutagen Stocks Known lesion Cdk8GD7022 in vitro construct - RNAi in vitro construct - regulatory fusion 3 Yes Cdk8GL00231 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Cdk8KK107735 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Cdk8dsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes Cdk8GMR.PB in vitro construct - regulatory fusion 0 Yes Cdk8NIG.10572R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Cdk8Ubi-p63E.PL in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)AC1 (Loncle et al., 2007) Df(3L)Cdk8K145 (Loncle et al., 2007)
Partially disrupted in	Df(3L)Cdk8K185 (Loncle et al., 2007)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7022} NA P{KK107735} NA P{NIG.10572R} NA P{TRiP.GL00231} NA P{VALIUM10-Cdk8.RNAi} NA characterization construct P{GMR-Cdk8.B} NA P{Ubi-p63E-Cdk8.L} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{?EP}I-2GE26681 NA PBac{5HPw+}Cdk8A162 NA PBac{PB}Cdk8c01804 NA
Gene Ontology: Function, Process & Cellular Component ( 14 unique terms )
Terms Based on Experimental Evidence ( 9 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
axon guidance inferred from mutant phenotype (Berger et al., 2008) cell cycle inferred from mutant phenotype (Kiger et al., 2003) chaeta development inferred from mutant phenotype (Loncle et al., 2007) imaginal disc-derived leg segmentation inferred from mutant phenotype (Loncle et al., 2007) mitotic G2 DNA damage checkpoint inferred from genetic interaction with nbs (Kondo and Perrimon, 2011) protein phosphorylation inferred from direct assay (assigned by UniProtKB) (Leclerc et al., 1996) sex comb development inferred from mutant phenotype (Loncle et al., 2007)
Cellular Component
CV term Evidence References
mediator complex inferred from direct assay (Park et al., 2003) inferred from physical interaction with CycC, kto, skd (Loncle et al., 2007) nucleus inferred from direct assay (Park et al., 2003) inferred from direct assay (assigned by UniProtKB) (Leclerc et al., 1996)
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR017441 (FlyBase Curators et al., 2004-) cyclin-dependent protein serine/threonine kinase activity inferred from sequence or structural similarity with UniProtKB:P39073 (FlyBase, 1992-) protein serine/threonine kinase activity non-traceable author statement (Leopold et al., 1996, Morrison et al., 2000) RNA polymerase II transcription cofactor activity inferred from sequence or structural similarity (Boube et al., 2000)
Biological Process
CV term Evidence References
protein phosphorylation non-traceable author statement (Morrison et al., 2000) transcription initiation from RNA polymerase II promoter inferred from sequence or structural similarity (Boube et al., 2000)
Cellular Component
CV term Evidence References
mediator complex inferred from sequence or structural similarity (Boube et al., 2000)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Cdk8 - Bap60 experimental knowledge based (Guruharsha et al., 2011) Cdk8 - CG12493 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cdk8 - CG15625 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cdk8 - CG17002 experimental knowledge based (Guruharsha et al., 2011) Cdk8 - CG2017 experimental knowledge based (Guruharsha et al., 2011) Cdk8 - CG3008 experimental knowledge based (Guruharsha et al., 2011) Cdk8 - CG30491 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cdk8 - CG32479 experimental knowledge based (Guruharsha et al., 2011) Cdk8 - CG34159 experimental knowledge based (Guruharsha et al., 2011) Cdk8 - CG5623 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cdk8 - CG7185 experimental knowledge based (Guruharsha et al., 2011) Cdk8 - CG7542 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cdk8 - CycC anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cdk8 - MED11 experimental knowledge based (Guruharsha et al., 2011) Cdk8 - MED14 experimental knowledge based (Guruharsha et al., 2011) Cdk8 - MED15 experimental knowledge based (Guruharsha et al., 2011) Cdk8 - MED16 experimental knowledge based (Guruharsha et al., 2011) Cdk8 - MED17 experimental knowledge based (Guruharsha et al., 2011) Cdk8 - MED18 experimental knowledge based (Guruharsha et al., 2011) Cdk8 - MED20 experimental knowledge based (Guruharsha et al., 2011) Cdk8 - MED23 experimental knowledge based (Guruharsha et al., 2011) Cdk8 - MED27 experimental knowledge based (Guruharsha et al., 2011) Cdk8 - MED30 experimental knowledge based (Guruharsha et al., 2011) Cdk8 - MED4 experimental knowledge based (Guruharsha et al., 2011) Cdk8 - MED6 experimental knowledge based (Guruharsha et al., 2011) Cdk8 - MED7 experimental knowledge based (Guruharsha et al., 2011) Cdk8 - MED8 experimental knowledge based (Guruharsha et al., 2011) Cdk8 - Ssdp experimental knowledge based (Guruharsha et al., 2011) Cdk8 - boca experimental knowledge based (Guruharsha et al., 2011) Cdk8 - brm experimental knowledge based (Guruharsha et al., 2011) Cdk8 - dsh experimental knowledge based (Guruharsha et al., 2011) Cdk8 - ebi experimental knowledge based (Guruharsha et al., 2011) Cdk8 - enc experimental knowledge based (Guruharsha et al., 2011) Cdk8 - fan anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cdk8 - fh anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cdk8 - ix experimental knowledge based (Guruharsha et al., 2011) Cdk8 - mor experimental knowledge based (Guruharsha et al., 2011) Cdk8 - osa experimental knowledge based (Guruharsha et al., 2011) Cdk8 - ptip experimental knowledge based (Guruharsha et al., 2011) Cdk8 - skd experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Cdk8 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64544 DroID - A comprehensive database of gene and protein interactions. • FBgn0015618 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39157 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9VT57
Orthologs
OrthoDB Orthologs (44) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG637S0Q Dipteran inclusive ortholog search EOG68PMTQ Insect inclusive ortholog search EOG67D8BH Arthropod inclusive ortholog search EOG6T4B9V Metazoa inclusive ortholog search EOG6Z3K7C
Orthologs in Drosophila Species (EOG637S0Q)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Cdk8     Drosophila simulans   Dsim\GD12888 Y   Drosophila sechellia   Dsec\GM24836 Y   Drosophila erecta   Dere\GG14001 Y   Drosophila yakuba   Dyak\GE20297 Y   Drosophila ananassae   Dana\GF10227 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA28311 Y   Drosophila persimilis   Dper\GL20758 Y   Drosophila willistoni   Dwil\GK12315 Y   Drosophila virilis   Dvir\GJ13608 Y   Drosophila mojavensis   Dmoj\GI11413 Y   Drosophila grimshawi   Dgri\GH16999     Drosophila grimshawi   Dgri\GH22186 Y
Orthologs in non-Drosophila Dipterans (EOG68PMTQ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL002395   Anopheles gambiae Malaria mosquito  Agam\AGAP009936   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ802454
Orthologs in non-Dipteran Insects (EOG67D8BH)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB45722   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG020283   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH11179   Atta cephalotes Leafcutter ant  Acep\ACEP18284   Camponotus floridanus Florida carpenter ant  Cflo\CFLO21871   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL18172   Linepithema humile Argentine ant  Lhum\LH23083   Pogonomyrmex barbatus Red harvester ant  Pbar\PB17787   Solenopsis invicta Red fire ant  Sinv\SINV23847   Acyrthosiphon pisum Pea aphid  Apim\ACYPI009537   Bombyx mori Silkmoth  Bmor\BGIBMGA011562   Pediculus humanus Human body louse  Phum\PHUM298010   Tribolium castaneum Red flour beetle  Tcas\TC004891
Orthologs in non-Insect Arthropods (EOG6T4B9V)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_204007   Daphnia pulex Water flea  Dpux\FAM186B   Ixodes scapularis Deer tick  Isca\ISCW018877
Orthologs in non-Arthropod Metazoa (EOG6Z3K7C)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\cdk-8   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_001690gn   Danio rerio Zebrafish  Drer\cdk19   Danio rerio Zebrafish  Drer\cdk8   Xenopus tropicalis Western clawed frog  Xtro\cdk8   Xenopus tropicalis Western clawed frog  Xtro\cdk19   Gallus gallus Domestic chicken  Ggal\CDK19   Gallus gallus Domestic chicken  Ggal\CDK8   Mus musculus House mouse  Mmus\Cdk19   Rattus norvegicus Norway rat  Rnor\Cdc2l6_predicted   Homo sapiens Human  Hsap\CDK8   Homo sapiens Human  Hsap\CDK19
Human Orthologs (2)
Gene OMIM HGNC Hsap\CDK8     Hsap\CDK19
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD12888 Drosophila sechellia Dsec\GM24836 Drosophila erecta Dere\GG14001 Drosophila yakuba Dyak\GE20297 Drosophila ananassae Dana\GF10227 Drosophila pseudoobscura pseudoobscura Dpse\GA28311 Drosophila persimilis Dper\GL20758 Drosophila willistoni Dwil\GK12315 Drosophila virilis Dvir\GJ13608 Drosophila mojavensis Dmoj\GI11413 Drosophila grimshawi Dgri\GH22186
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	35324 y1 sc* v1; P{TRiP.GL00231}attP2 16058 y1 w1118; PBac{5HPw+}Cdk8A162
Harvard	- PBac{PB}Cdk8c01804
VDRC	v107187 P{KK107735}VIE-260B v45371 w1118 P{GD7022}v45371 v31264 w1118; P{GD7022}v31264 v45370 w1118; P{GD7022}v45370
Genomic Clones ( 2 )
	BACR07A05 BACR07E07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 7 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE13344
Other clones	FI03233
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	RM06692 RM06792 RM06992 RM07192 RM07292
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0015618 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39157
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Cdk8 CG10572 (Li, 1999.11)
Source for database merge of
Additional comments
Other Comments
	dsRNA has been made from templates generated with primers directed against this gene. (Marr et al., 2006) When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of S phase cells seen. The proportion of G2/M phase cells is equal to proportion of G1 phase cells. (Bettencourt-Dias et al., 2004) Transcriptionally downregulated after 2h of insulin stimulation in Kc167 cells. Contains fkh response elements (FHREs) in the genomic upstream or intronic sequences. (Junger et al., 2003) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in S2R+ cells: cell size is increased, microtubules are uniform or disorganised, cell shape is irregular, and cell number is decreased indicative of a failure in cell cycle progression through G1 to S and G2 to M stages. This phenotype is not seen in Kc167 cells. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Cdk8 protein interacts in vivo with CycC protein and also with RpII215 protein. (Leclerc et al., 1996) Interacts in vitro and in vivo with CycC, also can interact in vivo with a large subunit RNA polymerase II. (Leopold et al., 1996)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080487 RefSeq (Proteins) • NP_536735 DDBJ / EMBL / GenBank • AAB38385 AAF50197 AAM50971 AJ249461 AY119111 BI171541 U33015 Entrez Gene - A searchable database of RefSeq genes. • 39157 UniProtKB/Swiss-Prot • Q9VT57
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine- / dual specificity protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • FI03233
Linkouts
	BioGRID - A database of protein and genetic interactions • 64544 DroID - A comprehensive database of gene and protein interactions. • FBgn0015618 DRSC - Results from RNAi screens. • FBgn0015618 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015618 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10572-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0015618 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39157 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/cdk8.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39157 modMine - Data generated by the modENCODE project. • FBgn0015618 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9VT57
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	Cdk8 (Wang et al., 2008, Ji et al., 2007, Marr et al., 2006, Kim and Lis, 2005, Garcia et al., 2007, Guglielmi et al., 2004, Levine and Tjian, 2003, de Ayala Alonso et al., 2007, Ardehali et al., 2009, Loncle et al., 2007, Raynaud-Messina et al., 2004, Gim et al., 2001, Berger et al., 2008, Gobert et al., 2010, Japanese National Institute of Genetics, 2012.5.21, Zhao et al., 2012) cdk8 (Brumby et al., 2004, Carrera et al., 2008, Berger et al., 2008) CDK8 (Bourbon et al., 2004, Boube et al., 2000, Kondo and Perrimon, 2011) CG10572 (Morrison et al., 2000, Boube et al., 2000, Ardehali et al., 2009, Keleman et al., 2009.8.5, Berger et al., 2008, Ni et al., 2011.7.19) dCdk8 (Morris et al., 2008) DmCdk8 (Leclerc et al., 1996) dTRAP56 (Boube et al., 2000) p58 (Park et al., 2001)
Name Synonym	Cyclin-dependent kinase 8 (Leopold et al., 1996)
Secondary FlyBase IDs
References ( 54 )
Generate a list of	All references relating to this gene ( 54 )
List References by type	Research paper  ( 26 ) Supplementary material  ( 6 ) Review  ( 2 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 3 ) FlyBase analysis  ( 1 ) Letter  ( 1 ) Conference report  ( 1 ) Stock list  ( 1 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 3 ) Website  ( 1 )
Recent research papers ( 3 )
	Baradaran-Heravi et al., 2012, Hum. Mol. Genet. 21(11): 2572--2587 Penetrance of biallelic SMARCAL1 mutations is associated with environmental and genetic disturbances of gene expression. [FBrf0218299] Zhao et al., 2012, J. Clin. Invest. 122(7): 2417--2427 Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1. [FBrf0218723] Kondo and Perrimon, 2011, Sci. Signal. 4(154): rs1 A Genome-Wide RNAi Screen Identifies Core Components of the G2-M DNA Damage Checkpoint. [FBrf0212700] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...