FB2020_06, released Dec 22, 2020

Gene: Dmel\Cnx99A

Open Close
General Information
Symbol
Dmel\Cnx99A
Species
D. melanogaster
Name
Calnexin 99A
Annotation Symbol
CG11958
Feature Type
protein_coding_gene
FlyBase ID
FBgn0015622
Gene Model Status
Current
Stock Availability
11 publicly available
Gene Snapshot
Calnexin 99A (Cnx99A) encodes an endoplasmic reticulum chaperone that colocalizes and genetically interacts with the sodium channel subunit encoded by para. [Date last reviewed: 2018-09-20]
Other Summaries
Also Known As

calnexin, Cnx

Key Links
Genomic Location
Cytogenetic map
99A7-99A7
Sequence location
3R:29,315,254..29,319,644 [-]
Recombination map

3-98

RefSeq locus
NT_033777 REGION:29315254..29319644
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (12 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables calcium ion binding
inferred from biological aspect of ancestor with PANTHER:PTN000117401
(assigned by GO_Central )
(Gaudet et al., 2011)
enables unfolded protein binding
inferred from electronic annotation with InterPro:IPR001580
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (6 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
involved_in protein stabilization
inferred from mutant phenotype
(Xiao et al., 2017)
involved_in regulation of calcium ion transport into cytosol
inferred from mutant phenotype
(Rosenbaum et al., 2006)
involved_in retina homeostasis
inferred from mutant phenotype
(Rosenbaum et al., 2006)
involved_in rhodopsin biosynthetic process
inferred from mutant phenotype
(Rosenbaum et al., 2006)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in endoplasmic reticulum unfolded protein response
inferred from biological aspect of ancestor with PANTHER:PTN000117401
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in protein folding
inferred from biological aspect of ancestor with PANTHER:PTN000117401
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in endomembrane system
inferred from high throughput direct assay
(Tan et al., 2009)
located_in perinuclear endoplasmic reticulum
inferred from direct assay
(Rosenbaum et al., 2006)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in endoplasmic reticulum membrane
inferred from biological aspect of ancestor with PANTHER:PTN000117401
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in plasma membrane
inferred from sequence or structural similarity
(Christodoulou et al., 1997)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Cnx99A for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Cnx99A-RA
FBtr0085437
NM_170407
2615
605
Cnx99A-RB
FBtr0085438
NM_057809
2623
605
Cnx99A-RD
FBtr0110909
NM_001043302
2092
605
Cnx99A-RE
FBtr0334873
NM_001043301
2620
604
Additional Transcript Data and Comments
Reported size (kB)

3.0 (northern blot)

(Hong and Ganetzky, 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Cnx99A-PA
FBpp0084803
68.0
605
4.45
NP_733286
AAF56887
Cnx99A-PB
FBpp0084804
68.0
605
4.45
NP_477157
AAN14170
Cnx99A-PD
FBpp0110209
68.0
605
4.45
NP_001036767
ABI31216
Cnx99A-PE
FBpp0306896
68.9
604
4.57
NP_001036766
ABI31215
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

605 aa isoforms: Cnx99A-PA, Cnx99A-PB, Cnx99A-PD
Additional Polypeptide Data and Comments
Reported size (kDa)

605 (aa)

(Christodoulou et al., 1997)

297 (aa)

(Hong and Ganetzky, 1996)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cnx99A using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 13 -- 16
larval midline neuron
(Kearney et al., 2004)
Additional Descriptive Data

The Cnx transcript is detected in the CNS and PNS of embryos after early neurogenesis.

(Hong and Ganetzky, 1996)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
photoreceptor cell
(Rosenbaum et al., 2006)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data

Cnx99A protein is detected in the endoplasmic reticulum of all eight photoreceptor cells.

(Rosenbaum et al., 2006)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in endomembrane system
inferred from high throughput direct assay
(Tan et al., 2009)
located_in perinuclear endoplasmic reticulum
inferred from direct assay
(Rosenbaum et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Cnx99A in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 6 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Cnx99A
Transgenic constructs containing regulatory region of Cnx99A
Deletions and Duplications ( 5 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4sca-4512
viable
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
flightless, with Scer\GAL4Mef2.PR
locomotor behavior defective | adult stage
locomotor behavior defective | adult stage, with Scer\GAL4elav.PU
neurophysiology defective
neurophysiology defective | third instar larval stage, with Scer\GAL4elav.PU
visible, with Scer\GAL4Act5C.PU
visible, with Scer\GAL4GMR.PU
Phenotype manifest in
Allele
bristle of mesothoracic tergum, with Scer\GAL4Act5C.PU
embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4elav.PU
endoplasmic reticulum
Golgi apparatus
intermediate longitudinal fascicle, with Scer\GAL4sca-4512
medial longitudinal fascicle, with Scer\GAL4sca-4512
medial longitudinal fascicle, with Scer\GAL4sim.PS
ommatidium, with Scer\GAL4GMR.PU
retina | conditional
rhabdomere of eye photoreceptor cell
rhabdomere R1
rhabdomere R2
rhabdomere R3
rhabdomere R4
rhabdomere R5
rhabdomere R6
terminal bouton | third instar larval stage, with Scer\GAL4elav.PU
ventral nerve cord, with Scer\GAL4sca-4512
ventral nerve cord, with Scer\GAL4sim.PS
ventral nerve cord commissure, with Scer\GAL4sca-4512
ventral nerve cord commissure, with Scer\GAL4sim.PS
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\CANX
13 of 15
Yes
No
Hsap\CLGN
10 of 15
No
No
Hsap\CALR
1 of 15
No
No
1  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Canx
14 of 15
Yes
Yes
Mmus\Clgn
10 of 15
No
Yes
Mmus\Calr
1 of 15
No
No
Rattus norvegicus (Norway rat) (2)
Rnor\Canx
12 of 13
Yes
Yes
Rnor\Clgn
11 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (3)
Xtro\canx
8 of 12
Yes
No
Xtro\clgn
3 of 12
No
Yes
Xtro\calr
1 of 12
No
No
Danio rerio (Zebrafish) (4)
Drer\canx
13 of 15
Yes
Yes
Drer\clgn
10 of 15
No
No
Drer\si:ch211-274f20.2
4 of 15
No
No
Drer\calr
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\cnx-1
13 of 15
Yes
Yes
Cele\crt-1
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (2)
Atha\AT5G07340
7 of 9
Yes
No
Atha\CNX1
6 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\CNE1
10 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\cnx1
8 of 12
Yes
No
Spom\SPBP4H10.19c
2 of 12
No
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091905DK )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00012979
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00013171
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00009470
Drosophila simulans
Dsim\GD15746
Drosophila simulans
Dsim\GD17820
Drosophila sechellia
Dsec\GM13395
Drosophila erecta
Dere\GG12019
Drosophila yakuba
Dyak\GE10455
Drosophila ananassae
Dana\GF22893
Drosophila pseudoobscura pseudoobscura
Dpse\GA26840
Drosophila persimilis
Dper\GL13597
Drosophila willistoni
Dwil\GK11031
Drosophila virilis
Dvir\GJ14222
Drosophila mojavensis
Dmoj\GI22345
Drosophila grimshawi
Dgri\GH14000
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150438 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17023584
Glossina morsitans
Tsetse fly
Gmor\GMOY003476
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_12733
Mayetiola destructor
Hessian fly
Mdes\Mdes016089
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL015100
Anopheles darlingi
American malaria mosquito
Adar\ADAC004485
Anopheles gambiae
Malaria mosquito
Agam\AGAP005032
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ009164
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W05YH )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA001097
Danaus plexippus
Monarch butterfly
Dple\DPOGS211902-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL017722
Apis florea
Little honeybee
Aflo\3291512404
Apis mellifera
Western honey bee
Amel\GB41147
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP14326
Bombus terrestris
Buff-tailed bumblebee
Bter\15204191
Linepithema humile
Argentine ant
Lhum\LH13853
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002ff9
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG001077
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_08835
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_07397
Pediculus humanus
Human body louse
Phum\PHUM544490
Cimex lectularius
Bed bug
Clec\CLEC003450
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004368
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_12471
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X074D )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR004678
Ixodes scapularis
Black-legged tick
Isca\ISCW003709
Ixodes scapularis
Black-legged tick
Isca\ISCW001834
Stegodyphus mimosarum
African social velvet spider
Smim\KFM72861.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g03150
Tetranychus urticae
Two-spotted spider mite
Turt\tetur27g00800
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_304937
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G04SS )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Canx
Ciona intestinalis
Vase tunicate
Cint\LOC100177539
Gallus gallus
Domestic chicken
Ggal\CANX
Gallus gallus
Domestic chicken
Ggal\CLGN
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (3)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Cnx14D
9 of 10
CG1924
8 of 10
Calr
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    CANX; calnexin
    13 of 15
    114217
        CLGN; calmegin
        10 of 15
        601858
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            esyN Network Diagram
            Show neighbor-neighbor interactions:
            Select Layout:
            Legend:
            Protein
            RNA
            Selected Interactor(s)
            Interactions Browser
            View in Interactions Browser
            Please see the Physical Interaction reports below for full details
            protein-protein
            Physical Interaction
            Assay
            References
            Cnx99A
            anti tag coimmunoprecipitation, anti tag western blot, anti bait coimmunoprecipitation, western blot
            (Xiao et al., 2017)
            Cnx99A - Acsl
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - Agpat3
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - AspRS
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - CCT3
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - CCT4
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - CCT6
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - CCT8
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - CDC50
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - CG10425
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - CG1092
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - CG13397
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - CG1371
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - CG17765
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - CG2064
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - CG2918
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - CG3008
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - CG33303
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - CG3902
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - CG5854
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - CaBP1
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - Cp1
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - Cyp12d1-p
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - Droj2
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - EMC1
            anti tag coimmunoprecipitation, western blot
            (Satoh et al., 2015)
            Cnx99A - GCS2β
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - Gfat2
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - Glt
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - GluProRS
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - Gp210
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - Gp93
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - Idh3a
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - Kap-α3
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - LanB1
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - MRP
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - Mcad
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - Mpcp2
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - Nfs1
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - OstΔ
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - PCB
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - Pen
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - Pi3K68D
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - Pp2A-29B
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - Rab5
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - RpS10b
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - RpS5a
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - Rpn1
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - Rpt1
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - SERCA
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - ScsβA
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - ScsβG
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - Sec61α
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - Sec63
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - SerRS
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - Spindly
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - Spt-I
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - TER94
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - TrpRS
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - UQCR-6.4
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - UQCR-C2
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - Vps4
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - boca
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - bor
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - cathD
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - fax
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - lic
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - mEFTu1
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - ninaE
            pull down, western blot, anti bait coimmunoprecipitation
            (Chen et al., 2015, Rosenbaum et al., 2006)
            Cnx99A - p23
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - r
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - scf
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - wal
            experimental knowledge based
            (Guruharsha et al., 2011)
            Cnx99A - βCOP
            experimental knowledge based
            (Guruharsha et al., 2011)
            Summary of Genetic Interactions
            esyN Network Diagram
            esyN Network Key:
            Suppression
            Enhancement
            View in Interactions Browser
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Cnx99A
            suppressible
            norpA
            (Rosenbaum et al., 2006)
            Cnx99A
            suppressible
            para
            (Xiao et al., 2017)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            kay
            enhanceable
            Cnx99A
            (Franciscovich et al., 2008)
            kay
            suppressible
            Cnx99A
            (Franciscovich et al., 2008)
            para
            suppressible
            Cnx99A
            (Xiao et al., 2017)
            para
            enhanceable
            Cnx99A
            (Xiao et al., 2017)
            External Data
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            External Data
            Linkouts
            KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            3R
            Recombination map

            3-98

            Cytogenetic map
            99A7-99A7
            Sequence location
            3R:29,315,254..29,319,644 [-]
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            99A7-99A7
            Limits computationally determined from genome sequence between P{PZ}l(3)0674306743 and P{PZ}ncd05884
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            99A1-99A6
            (determined by in situ hybridisation)
            (Christodoulou et al., 1997)
            Specific note is made that FBrf0086460 reported a calnexin in 14D, that there are some but few sequence differences, and that the probe used here fails to hybridise anywhere but 99A.
            (Christodoulou et al., 1997)
            Experimentally Determined Recombination Data
            Location

            3-98

            (FlyBase, 2016)

            3-95.6

            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (11)
            Genomic Clones (19)
            cDNA Clones (146)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            DRSC - Results frm RNAi screens
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            Antibody Information
            Laboratory Generated Antibodies
             

            monoclonal

            (Riedel et al., 2016)

            polyclonal

            (Satoh et al., 2015, Rosenbaum et al., 2006)
            Commercially Available Antibodies
             
            Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
            Other Information
            Relationship to Other Genes
            Source for database identify of
            Source for database merge of

            Source for merge of: Cnx99A CG11958

            (Bayraktaroglu, 2000.4.17)
            Additional comments
            Other Comments
            Origin and Etymology
            Discoverer
            Etymology
            Identification
            External Crossreferences and Linkouts ( 70 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            Flygut - An atlas of the Drosophila adult midgut
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            modMine - A data warehouse for the modENCODE project
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
            FLIGHT - Cell culture data for RNAi and other high-throughput technologies
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            FlyMine - An integrated database for Drosophila genomics
            Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Synonyms and Secondary IDs (11)
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            References (91)