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Gene Dmel\Cpr

General Information
Symbol	Dmel\Cpr	Species	D. melanogaster
Name	Cytochrome P450 reductase	Annotation symbol	CG11567
Feature type	protein_coding_gene	FlyBase ID	FBgn0015623
Gene Model Status	Current	Stock availability	10 publicly available
Also Known As	P450
Genomic Location
Chromosome (arm)	2L	Recombination map	2-
Cytogenetic map	26C3-26C3	Sequence location	2L:6,338,772..6,346,282 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Cytochrome P450 reductase is referred to in FlyBase by the symbol Dmel\Cpr (CG11567, FBgn0015623). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: NADPH-hemoprotein reductase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: oxidation-reduction process. 14 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: FAD-binding, type 1; Ferredoxin reductase-type FAD-binding domain; Flavodoxin; Flavodoxin/nitric oxide synthase; Flavoprotein pyridine nucleotide cytochrome reductase; NADPH-cytochrome P450 reductase; NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain-3; Oxidoreductase FAD/NAD(P)-binding; Riboflavin synthase-like beta-barrel. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-06 and 18-24 hour embryonic stages, during late pupal stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult thoracico-abdominal ganglion, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, adult salivary gland, adult female reproductive system, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval fat body, larval salivary gland, larval trachea, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1631637_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Cpr. Gene sequence location is 2L:6338772..6346282.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Insertions P{Tb[1]}Cpr[CyO-A] Alleles Cpr[CyO-A] Sequence features BKN22919 HFA03293 References Lattao et al., 2011, Fly 5(4): 369--370
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 26C3-26C3   Limits computationally determined from genome sequence between P{lacW}Gef26k13720 and P{lacW}l(2)k09923k09923&P{lacW}CG9523k07502b
Experimentally Determined Cytological Location
Cytogenetic map Notes References 26C-26C     (Hovemann, 1995.11.16) 26C-26C   (determined by in situ hybridisation)   (Hovemann et al., 1997)
Experimentally Determined Recombination Data
Location	2- (Hovemann, 1995.11.16)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Cpr for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Cpr-RA FBtr0079250  NM_057810   2805   679 Cpr-RB FBtr0079251  NM_164689   2132   550
Additional Transcript Data & Comments
Reported size (kB)	2.7 (northern blot) (Hovemann et al., 1997)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Cpr-PA   FBpp0078880   76.3   679   5.70     NP_477158   AAF52367 Cpr-PB   FBpp0078881   62.9   550   8.38     NP_723173   AAN10585
Additional Polypeptide Data & Comments
Reported size (kDa)	679 (aa); 76 (kD predicted) (Hovemann et al., 1997)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Oxidoreductase FAD/NAD(P)-binding (IPR001433) Flavoprotein pyridine nucleotide cytochrome reductase (IPR001709) FAD-binding, type 1 (IPR003097) Flavodoxin/nitric oxide synthase (IPR008254) Ferredoxin reductase-type FAD-binding domain (IPR017927) Riboflavin synthase-like beta-barrel (IPR017938) Flavodoxin (IPR001094) NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain-3 (IPR023173) NADPH-cytochrome P450 reductase (IPR023208)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201899   AA201901   AA202551   AA263340   AA390752   AA390906   AA438481   AA439853   AA439926   AA440294   AA441324   AA539803   AA567966   AA697913   AA698300   AA816771   AA817647   AA941540   AA949948   AA950347   AA950620   AA978710   AA979362   AE014134 AAF52367   AE014134 AAN10585   AC004568   AC005285   AC093100   AI062667   AI063166   AI063167   AI063168   AI107415   AI108259   AI388275   AI455083   AI457001   AI512476   AI512565   AI512629   AI514816   AI514950   AI514953   AI515253   AI516356   AI516434   AI516766   AI517162   AI531616   AI546454   AI946162   AK255036   AW943855   AY052000 AAK93424   BF505018   BG633478   BG637163   BG640711   BI167063   BI168040   BI168793   BI168951   BI172048   BI212666   BI227770   BI229864   BI234495   BI235952   BI238700   BI241970   BI355959   BI356002   BI367608   BI367739   BI368525   BI370316   BI370561   BI373609   BI483542   BI485233   BI577593   BI578718   BI580007   BI580510   BI634051   BI635751   BI639704   BI641691   BQ103550   BT100044   CK132831   CK659286   CO153325   CO153371   CO156318   CO282389   CO292177   CO299760   CO315846   CO333462   CO335787   CO339786   CZ472744   CZ474385   CZ475264   CZ478944   DN154011   EC071240   EC084664   EC089315   EC199755   EC213999   EC233984   EC246986   EC247681   EC255290   EC264540   EC264542   EC266661   EV577426   EV579155   EV586385   EV586482   EV586797   EV586869   EV587278   EV587341   EV587897   EV587993   EV588365   EV588683   EV589938   EV590144   EV590501   EV591593   EV591719   EV591991   GH738875   GH738996   GH739253   GH739421   GH739424   GH739606   GH740446   GH740506   GH741453   GH742170   GH742658   GH742737   GH743136   GH743149   GH743196   GH743902   GH743998   GH744043   GH744109   GH744301   GH744332   GH744547   GH744633   GH745119   GH745309   GH745919   GH746144   GH746506   GH746704   GH746918   GH746970   GH747060   GH747500   GH747582   GH761531   GH761695   GH761912   GH761954   GH762378   GH762811   GH762873   GH763256   GH763287   GH763509   GH763763   GH764049   GH764221   GH764270   GH764403   GH764438   GH764549   GH764697   GH764723   GH764903   GH765200   GH765405   GH765753   GH765945   GH766043   GH766487   GH767122   GH767284   GH767362   GH767815   GH767981   GH768003   GH768405   GH768626   GH768671   GH769021   GH769034   GH769109   GH769499   GH769612   GH769808   GH770036   GH770066   X93090 CAA63639
UniProtKB/Swiss-Prot	Q27597
UniProtKB/TrEMBL	Q8IPJ7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Hovemann et al., 1997) adult stage   antenna   (Hovemann et al., 1997)
Additional Descriptive Data
	High levels of Cpr transcripts are detected in adult antennae and in embryos. (Hovemann et al., 1997)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0015623    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0015623 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-06 and 18-24 hour embryonic stages, during late pupal stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0015623 expression level Developmental Stage   Expression Level embryo 00-02hr    11272 embryo 02-04hr    11597 embryo 04-06hr    6260 embryo 06-08hr    8335 embryo 08-10hr    9112 embryo 10-12hr    8149 embryo 12-14hr    5376 embryo 14-16hr    4613 embryo 16-18hr    9346 embryo 18-20hr    11639 embryo 20-22hr    15461 embryo 22-24hr    13874 larva L1    6471 larva L2    8266 larva L3 12hr old    9716 larva L3 puffstage 1-2    3952 larva L3 puffstage 3-6    3067 larva L3 puffstage 7-9    2385 white prepupae new    2351 white prepupae 12hr    2099 white prepupae 24hr    2586 pupae 2d postWPP    2748 pupae 3d postWPP    5146 pupae 4d postWPP    12698 adult male 01day    22563 adult male 05day    31256 adult male 30day    23205 adult female 01day    14892 adult female 05day    11132 adult female 30day    12027 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (11272) embryo 02-04hr  (11597) embryo 04-06hr  (6260) embryo 06-08hr  (8335) embryo 08-10hr  (9112) embryo 10-12hr  (8149) embryo 12-14hr  (5376) embryo 14-16hr  (4613) embryo 16-18hr  (9346) embryo 18-20hr  (11639) embryo 20-22hr  (15461) embryo 22-24hr  (13874) larva L1  (6471) larva L2  (8266) larva L3 12hr old  (9716) larva L3 puffstage 1-2  (3952) larva L3 puffstage 3-6  (3067) larva L3 puffstage 7-9  (2385) white prepupae new  (2351) white prepupae 12hr  (2099) white prepupae 24hr  (2586) pupae 2d postWPP  (2748) pupae 3d postWPP  (5146) pupae 4d postWPP  (12698) adult male 01day  (22563) adult male 05day  (31256) adult male 30day  (23205) adult female 01day  (14892) adult female 05day  (11132) adult female 30day  (12027) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (11272) embryo 02-04hr  (11597) embryo 04-06hr  (6260) embryo 06-08hr  (8335) embryo 08-10hr  (9112) embryo 10-12hr  (8149) embryo 12-14hr  (5376) embryo 14-16hr  (4613) embryo 16-18hr  (9346) embryo 18-20hr  (11639) embryo 20-22hr  (15461) embryo 22-24hr  (13874) larva L1  (6471) larva L2  (8266) larva L3 12hr old  (9716) larva L3 puffstage 1-2  (3952) larva L3 puffstage 3-6  (3067) larva L3 puffstage 7-9  (2385) white prepupae new  (2351) white prepupae 12hr  (2099) white prepupae 24hr  (2586) pupae 2d postWPP  (2748) pupae 3d postWPP  (5146) pupae 4d postWPP  (12698) adult male 01day  (22563) adult male 05day  (31256) adult male 30day  (23205) adult female 01day  (14892) adult female 05day  (11132) adult female 30day  (12027) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (11272) embryo 02-04hr  (11597) embryo 04-06hr    6260 embryo 06-08hr    8335 embryo 08-10hr    9112 embryo 10-12hr    8149 embryo 12-14hr    5376 embryo 14-16hr    4613 embryo 16-18hr    9346 embryo 18-20hr  (11639) embryo 20-22hr  (15461) embryo 22-24hr  (13874) larva L1    6471 larva L2    8266 larva L3 12hr old    9716 larva L3 puffstage 1-2    3952 larva L3 puffstage 3-6    3067 larva L3 puffstage 7-9    2385 white prepupae new    2351 white prepupae 12hr    2099 white prepupae 24hr    2586 pupae 2d postWPP    2748 pupae 3d postWPP    5146 pupae 4d postWPP  (12698) adult male 01day  (22563) adult male 05day  (31256) adult male 30day  (23205) adult female 01day  (14892) adult female 05day  (11132) adult female 30day  (12027) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    11272 embryo 02-04hr    11597 embryo 04-06hr    6260 embryo 06-08hr    8335 embryo 08-10hr    9112 embryo 10-12hr    8149 embryo 12-14hr    5376 embryo 14-16hr    4613 embryo 16-18hr    9346 embryo 18-20hr    11639 embryo 20-22hr    15461 embryo 22-24hr    13874 larva L1    6471 larva L2    8266 larva L3 12hr old    9716 larva L3 puffstage 1-2    3952 larva L3 puffstage 3-6    3067 larva L3 puffstage 7-9    2385 white prepupae new    2351 white prepupae 12hr    2099 white prepupae 24hr    2586 pupae 2d postWPP    2748 pupae 3d postWPP    5146 pupae 4d postWPP    12698 adult male 01day    22563 adult male 05day    31256 adult male 30day    23205 adult female 01day    14892 adult female 05day    11132 adult female 30day    12027 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0015623 expression level Developmental Stage   Expression Level embryo 00-02hr    11272 embryo 02-04hr    11597 embryo 04-06hr    6260 embryo 06-08hr    8335 embryo 08-10hr    9112 embryo 10-12hr    8149 embryo 12-14hr    5376 embryo 14-16hr    4613 embryo 16-18hr    9346 embryo 18-20hr    11639 embryo 20-22hr    15461 embryo 22-24hr    13874 larva L1    6471 larva L2    8266 larva L3 12hr old    9716 larva L3 puffstage 1-2    3952 larva L3 puffstage 3-6    3067 larva L3 puffstage 7-9    2385 white prepupae new    2351 white prepupae 12hr    2099 white prepupae 24hr    2586 pupae 2d postWPP    2748 pupae 3d postWPP    5146 pupae 4d postWPP    12698 adult male 01day    22563 adult male 05day    31256 adult male 30day    23205 adult female 01day    14892 adult female 05day    11132 adult female 30day    12027 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (11272) embryo 02-04hr  (11597) embryo 04-06hr  (6260) embryo 06-08hr  (8335) embryo 08-10hr  (9112) embryo 10-12hr  (8149) embryo 12-14hr  (5376) embryo 14-16hr  (4613) embryo 16-18hr  (9346) embryo 18-20hr  (11639) embryo 20-22hr  (15461) embryo 22-24hr  (13874) larva L1  (6471) larva L2  (8266) larva L3 12hr old  (9716) larva L3 puffstage 1-2  (3952) larva L3 puffstage 3-6  (3067) larva L3 puffstage 7-9  (2385) white prepupae new  (2351) white prepupae 12hr  (2099) white prepupae 24hr  (2586) pupae 2d postWPP  (2748) pupae 3d postWPP  (5146) pupae 4d postWPP  (12698) adult male 01day  (22563) adult male 05day  (31256) adult male 30day  (23205) adult female 01day  (14892) adult female 05day  (11132) adult female 30day  (12027) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (11272) embryo 02-04hr  (11597) embryo 04-06hr  (6260) embryo 06-08hr  (8335) embryo 08-10hr  (9112) embryo 10-12hr  (8149) embryo 12-14hr  (5376) embryo 14-16hr  (4613) embryo 16-18hr  (9346) embryo 18-20hr  (11639) embryo 20-22hr  (15461) embryo 22-24hr  (13874) larva L1  (6471) larva L2  (8266) larva L3 12hr old  (9716) larva L3 puffstage 1-2  (3952) larva L3 puffstage 3-6  (3067) larva L3 puffstage 7-9  2385 white prepupae new  2351 white prepupae 12hr  2099 white prepupae 24hr  (2586) pupae 2d postWPP  (2748) pupae 3d postWPP  (5146) pupae 4d postWPP  (12698) adult male 01day  (22563) adult male 05day  (31256) adult male 30day  (23205) adult female 01day  (14892) adult female 05day  (11132) adult female 30day  (12027) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  11272 embryo 02-04hr  11597 embryo 04-06hr    6260 embryo 06-08hr    8335 embryo 08-10hr    9112 embryo 10-12hr    8149 embryo 12-14hr    5376 embryo 14-16hr    4613 embryo 16-18hr    9346 embryo 18-20hr  11639 embryo 20-22hr  15461 embryo 22-24hr  13874 larva L1    6471 larva L2    8266 larva L3 12hr old    9716 larva L3 puffstage 1-2    3952 larva L3 puffstage 3-6    3067 larva L3 puffstage 7-9    2385 white prepupae new    2351 white prepupae 12hr    2099 white prepupae 24hr    2586 pupae 2d postWPP    2748 pupae 3d postWPP    5146 pupae 4d postWPP  12698 adult male 01day  (22563) adult male 05day  (31256) adult male 30day  (23205) adult female 01day  14892 adult female 05day  11132 adult female 30day  12027 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    11272 embryo 02-04hr    11597 embryo 04-06hr    6260 embryo 06-08hr    8335 embryo 08-10hr    9112 embryo 10-12hr    8149 embryo 12-14hr    5376 embryo 14-16hr    4613 embryo 16-18hr    9346 embryo 18-20hr    11639 embryo 20-22hr    15461 embryo 22-24hr    13874 larva L1    6471 larva L2    8266 larva L3 12hr old    9716 larva L3 puffstage 1-2    3952 larva L3 puffstage 3-6    3067 larva L3 puffstage 7-9    2385 white prepupae new    2351 white prepupae 12hr    2099 white prepupae 24hr    2586 pupae 2d postWPP    2748 pupae 3d postWPP    5146 pupae 4d postWPP    12698 adult male 01day    22563 adult male 05day    31256 adult male 30day    23205 adult female 01day    14892 adult female 05day    11132 adult female 30day    12027 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0015623    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0015623 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult thoracico-abdominal ganglion, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, adult salivary gland, adult female reproductive system, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval fat body, larval salivary gland, larval trachea, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0015623 expression level Tissue   Expression Level Larval Central Nervous System    227.3 Larval Midgut    1468.9 Larval Hindgut    775.7 Larval Malpighian Tubules    726.4 Larval Fat Body    265.6 Larval Salivary Gland    315.1 Larval Trachea    418.475 Larval Carcass    713.75 Adult Head    940.9 Adult Eye    658.525 Adult Brain    376.1 Adult Thoracic-Abdominal Ganglion    500 Adult Crop    1381.1 Adult Midgut    915 Adult Hindgut    1000.8 Adult Malpighian Tubules    1751.6 Adult Fat Body    5183.2 Adult Salivary Gland    887.1 Adult Heart    5592.425 Adult VirginFemale Spermatheca    1056.4 Adult InseminatedFemale Spermatheca    1248.9 Adult Ovary    805.3 Adult Testis    143.7 Adult Male Accessory Gland    1406.2 Adult Carcass    4471.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    227.3 Larval Midgut  (1468.9) Larval Hindgut  (775.7) Larval Malpighian Tubules  (726.4) Larval Fat Body    265.6 Larval Salivary Gland    315.1 Larval Trachea    418.475 Larval Carcass  (713.75) Adult Head  (940.9) Adult Eye  (658.525) Adult Brain    376.1 Adult Thoracic-Abdominal Ganglion  500 Adult Crop  (1381.1) Adult Midgut  (915) Adult Hindgut  (1000.8) Adult Malpighian Tubules  (1751.6) Adult Fat Body  (5183.2) Adult Salivary Gland  (887.1) Adult Heart  (5592.425) Adult VirginFemale Spermatheca  (1056.4) Adult InseminatedFemale Spermatheca  (1248.9) Adult Ovary  (805.3) Adult Testis    143.7 Adult Male Accessory Gland  (1406.2) Adult Carcass  (4471.4) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    227.3 Larval Midgut  (1468.9) Larval Hindgut    775.7 Larval Malpighian Tubules    726.4 Larval Fat Body    265.6 Larval Salivary Gland    315.1 Larval Trachea    418.475 Larval Carcass    713.75 Adult Head    940.9 Adult Eye    658.525 Adult Brain    376.1 Adult Thoracic-Abdominal Ganglion    500 Adult Crop  (1381.1) Adult Midgut    915 Adult Hindgut  1000.8 Adult Malpighian Tubules  (1751.6) Adult Fat Body  (5183.2) Adult Salivary Gland    887.1 Adult Heart  (5592.425) Adult VirginFemale Spermatheca  1056.4 Adult InseminatedFemale Spermatheca  (1248.9) Adult Ovary    805.3 Adult Testis    143.7 Adult Male Accessory Gland  (1406.2) Adult Carcass  (4471.4) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    227.3 Larval Midgut    1468.9 Larval Hindgut    775.7 Larval Malpighian Tubules    726.4 Larval Fat Body    265.6 Larval Salivary Gland    315.1 Larval Trachea    418.475 Larval Carcass    713.75 Adult Head    940.9 Adult Eye    658.525 Adult Brain    376.1 Adult Thoracic-Abdominal Ganglion    500 Adult Crop    1381.1 Adult Midgut    915 Adult Hindgut    1000.8 Adult Malpighian Tubules    1751.6 Adult Fat Body    5183.2 Adult Salivary Gland    887.1 Adult Heart    5592.425 Adult VirginFemale Spermatheca    1056.4 Adult InseminatedFemale Spermatheca    1248.9 Adult Ovary    805.3 Adult Testis    143.7 Adult Male Accessory Gland    1406.2 Adult Carcass    4471.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0015623 expression level Tissue   Expression Level Larval Central Nervous System    227.3 Larval Midgut    1468.9 Larval Hindgut    775.7 Larval Malpighian Tubules    726.4 Larval Fat Body    265.6 Larval Salivary Gland    315.1 Larval Trachea    418.475 Larval Carcass    713.75 Adult Head    940.9 Adult Eye    658.525 Adult Brain    376.1 Adult Thoracic-Abdominal Ganglion    500 Adult Crop    1381.1 Adult Midgut    915 Adult Hindgut    1000.8 Adult Malpighian Tubules    1751.6 Adult Fat Body    5183.2 Adult Salivary Gland    887.1 Adult Heart    5592.425 Adult VirginFemale Spermatheca    1056.4 Adult InseminatedFemale Spermatheca    1248.9 Adult Ovary    805.3 Adult Testis    143.7 Adult Male Accessory Gland    1406.2 Adult Carcass    4471.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    227.3 Larval Midgut  (1468.9) Larval Hindgut  775.7 Larval Malpighian Tubules  726.4 Larval Fat Body    265.6 Larval Salivary Gland    315.1 Larval Trachea    418.475 Larval Carcass  713.75 Adult Head  (940.9) Adult Eye  658.525 Adult Brain    376.1 Adult Thoracic-Abdominal Ganglion  500 Adult Crop  (1381.1) Adult Midgut  (915) Adult Hindgut  (1000.8) Adult Malpighian Tubules  (1751.6) Adult Fat Body  (5183.2) Adult Salivary Gland  (887.1) Adult Heart  (5592.425) Adult VirginFemale Spermatheca  (1056.4) Adult InseminatedFemale Spermatheca  (1248.9) Adult Ovary  805.3 Adult Testis    143.7 Adult Male Accessory Gland  (1406.2) Adult Carcass  (4471.4) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    227.3 Larval Midgut  1468.9 Larval Hindgut    775.7 Larval Malpighian Tubules    726.4 Larval Fat Body    265.6 Larval Salivary Gland    315.1 Larval Trachea    418.475 Larval Carcass    713.75 Adult Head    940.9 Adult Eye    658.525 Adult Brain    376.1 Adult Thoracic-Abdominal Ganglion    500 Adult Crop  1381.1 Adult Midgut    915 Adult Hindgut  1000.8 Adult Malpighian Tubules  (1751.6) Adult Fat Body  (5183.2) Adult Salivary Gland    887.1 Adult Heart  (5592.425) Adult VirginFemale Spermatheca  1056.4 Adult InseminatedFemale Spermatheca  1248.9 Adult Ovary    805.3 Adult Testis    143.7 Adult Male Accessory Gland  1406.2 Adult Carcass  (4471.4) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    227.3 Larval Midgut    1468.9 Larval Hindgut    775.7 Larval Malpighian Tubules    726.4 Larval Fat Body    265.6 Larval Salivary Gland    315.1 Larval Trachea    418.475 Larval Carcass    713.75 Adult Head    940.9 Adult Eye    658.525 Adult Brain    376.1 Adult Thoracic-Abdominal Ganglion    500 Adult Crop    1381.1 Adult Midgut    915 Adult Hindgut    1000.8 Adult Malpighian Tubules    1751.6 Adult Fat Body    5183.2 Adult Salivary Gland    887.1 Adult Heart    5592.425 Adult VirginFemale Spermatheca    1056.4 Adult InseminatedFemale Spermatheca    1248.9 Adult Ovary    805.3 Adult Testis    143.7 Adult Male Accessory Gland    1406.2 Adult Carcass    4471.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    940.9   NA  Eye    658.525   NA  Brain    376.1   227.3  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    500   NA  Crop    1381.1   1468.9  Midgut    915   775.7  Hindgut    1000.8   726.4  Malpighian Tubules    1751.6   265.6  Fat Body    5183.2   315.1  Salivary Gland    887.1   NA  Heart    5592.425   418.475  Trachea    NA   NA  VirginFemale Spermatheca    1056.4   NA  InseminatedFemale Spermatheca    1248.9   NA  Ovary    805.3   NA  Testis    143.7   NA  Male Accessory Gland    1406.2   713.75  Carcass    4471.4 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_26
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015623 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11567-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Cpr Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4pnr-MD237 CprGD945 lethal | larval stage | recessive Cpre2 Cpre3 lethal | pupal stage, with Scer\GAL4pnr-MD237 CprGD945 lethal | recessive Cpre5 Phenotype manifest in Allele
Classical Alleles ( 12 )
For All Classical Alleles Show
Allele of Cpr Class Mutagen Stocks Known lesion CprCB-0872-3 1 -- CprCyO-A 1 Yes Cprd02317 P-element activity 1 -- CprDP01397 1 -- Cpre01125 piggyBac transposase 1 -- CprEY02046 P-element activity 1 -- CprCB-6199-3 0 -- Cprd05204 P-element activity 0 -- Cprd06651 P-element activity 0 -- Cpre2 ethyl methanesulfonate 0 -- Cpre3 ethyl methanesulfonate 0 -- Cpre5 ethyl methanesulfonate 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Cpr Class Mutagen Stocks Known lesion CprGD945 in vitro construct - RNAi in vitro construct - regulatory fusion 3 Yes CprKK102823 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel6016 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD945} NA P{KK102823} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}CprEY02046 NA P{Mae-UAS.6.11}CprDP01397 NA P{XP}Cprd02317 NA P{XP}Cprd05204 NA P{XP}Cprd06651 NA miscellaneous insertions P{RS3}CprCB-0872-3 NA P{RS3}CprCB-6199-3 NA P{Tb1}CprCyO-A NA PBac{RB}Cpre01125 NA
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
lipid particle inferred from direct assay (Beller et al., 2006)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
FMN binding inferred from electronic annotation with InterPro:IPR001094, InterPro:IPR008254 (FlyBase Curators et al., 2004-) iron ion binding inferred from electronic annotation with InterPro:IPR001094 (FlyBase Curators et al., 2004-) NADPH-hemoprotein reductase activity inferred from sequence or structural similarity with UniProtKB:Q07994 (FlyBase, 1992-) non-traceable author statement (Hovemann, 1995.11.16, Swiss-Prot Project Members, 2001.10.16)
Biological Process
CV term Evidence References
oxidation-reduction process inferred from electronic annotation with InterPro:IPR001094, InterPro:IPR001433, InterPro:IPR001709, InterPro:IPR003097, InterPro:IPR017927, InterPro:IPR017938, InterPro:IPR023173, InterPro:IPR023208 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
endoplasmic reticulum non-traceable author statement (Swiss-Prot Project Members, 2001.10.16)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Cpr allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60040 DroID - A comprehensive database of gene and protein interactions. • FBgn0015623 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33883
Orthologs
Genome-wide drosophilid orthologs	Dana\GF14516 Dere\GG10405 Dgri\GH10739 Dmoj\GI11531 Dper\GL25521 Dpse\GA11069 Dsec\GM18621 Dsim\GD23403 Dvir\GJ12806 Dwil\GK14755 Dyak\GE13802
Curated drosophilid orthologs	Dmet\Ncpr   Dpse\GA11069
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL003349-PA Aedes aegypti (mosquito) AGAP000500-PA Anopheles gambiae (mosquito) XP_001119949.1 Apis mellifera (honey bee) XP_001945312.1 Acyrthosiphon pisum (pea aphid) At4g24520.1 Arabidopsis thaliana (wall cress) 34195 Batrachochytrium dendrobatidis (chytrid fungus) 287024 Branchiostoma floridae (lancelet) 288748 Branchiostoma floridae (lancelet) XP_001899759.1 Brugia malayi (roundworm nematode) BGIBMGA006837-PA Bombyx mori (silk worm) ENSBTAP00000022718 Bos taurus (bovine) CAL0003511 Candida albicans (a form of yeast) CN20142 Caenorhabditis brenneri (small nematode) CBP00963 Caenorhabditis briggsae (nematode) CE02018 Caenorhabditis elegans (worm) ENSCAFP00000019835 Canis familiaris (dog) CAGL0D04114g Candida glabrata (haploid yeast) Chro.40304 Cryptosporidium hominis (obligate parasite) ENSCINP00000017605 Ciona intestinalis (sea squirt) JA05425 Caenorhabditis japonica (nematode) CMR440C Cyanidioschyzon merolae (red alga) cn04505 Cryptococcus neoformans (yeast-like fungus) cgd4_2700 Cryptosporidium parvum (protozoan parasite) CPIJ014664 Culex pipens (mosquito) ENSCPOP00000005592 Cavia porcellus (guinea pig) 116375 Chlamidomonas reinhardtii (green alga) RP27249 Caenorhabditis remanei (nematode) ENSCSAVP00000005677 Ciona savignyi (sedentary tunicate) 173459 Capitella spl (polychaete worm) DDB0266665 Dictyostelium discoideum (amoeba) DEHA2G17578g Debaryomyces Hansenii (yeast) 300447 Daphnia pulex (daphnia) ENSDARP00000017908 Danio rerio (zebra fish) ENSECAP00000007060 Equus caballus (horse) NP_417244.1 Escherichia coli K12 (bacteria) ENSGACP00000010198 Gymnopilus aculeatus (mushroom) ENSGALP00000003187 Gallus gallus (chicken) GL50803_15897 Giardia lamblia (flagellated protozoan) 113572 Hypsipyla robusta (cedar shoot borer) ENSP00000265302 Homo sapiens (human) ISCW020316-PA Ixodes scapularis (deer tick) KLLA0D08712g Kluyveromyces lactis (yeast) 187717 Lottia gigantea (owl limpet) LmjF28.1240 Leishmania major (virus) 16143 Monocosta brevicollis (choanoflagellate) ENSMODP00000028496 Monodelphis domestica (gray opossum) ENSMMUP00000026433 Macaca mulatta (rhesus monkey) ENSMUSP00000005651 Mus musculus (house mouse) 187451 Nematostella vectensis (starlet anemone) ENSOANP00000018353 Ornithorynchus anatinus (platypus) ENSORLP00000014273 Oryzias latipes (japanese killifish) LOC_Os09g38620.1 Oryza sativa (asian rice) 14922 Ostreococcus tauri (green alga) PFI1140w Plasmodium falciparum (protozoal parasite) PHUM000248-PA Pediculus humanus (human body louse) 201169 Physcomitrella patens (moss) ENSPPYP00000019589 Pongo pygmaeus (orangutan) 71492 Phytophthora ramorum (sudden oak death pathogen) 142875 Phytophthora sojae (root rot pathogen) 818445 Populus trichocarpa (black cottonwood) ENSPTRP00000033034 Pan troglodytes (chimpanzee) PVX_099570 Plasmodium vivax (protozoal parasite) ENSRNOP00000001961 Rattus norvegicus (norway rat) 5051622 Sorghum bicolor (sorghum) YHR042W Saccharomyces cerevisiae (budding yeast) Smp_030760 Schistosoma mansoni (trematode parasite) SPBC29A10.01 Schizosaccharomyces pombe (fission yeast) XP_799192.2 Strongylocentrotus purpuratus (purple sea urchin) 63169 Trichoplax adhaerens (metazoa) TA05915 Theileria annulata (apicomplexan parasite) XP_971174.1 Tribolium castaneum (red flour beetle) Tc00.1047053506585.70 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000006669 Tetraodon nigroviridis (green spotted pufferfish) TP03_0092 Theileria parva (parasitic protozoan) 264678 Thalassiosira pseudonana (marine diatom) ENSTRUP00000018392 Takifugu rubripes (pufferfish Takifugu) 196.m00061 Tetrahymena thermophila (ciliate protozoa) 84843.m00225 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000019690 Xenopus tropicalis (frog) YALI0D04422g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • LH22946 ISCW020316 FBgn0231454 FBgn0216760 FBgn0200041 FBgn0194788 FBgn0173527 JGI_V11_300447 FBgn0071124 FBgn0163105 FBgn0134291 FBgn0118220 FBgn0102714 FBgn0091543 CPIJ014664 BGIBMGA006837 ACYPI001593 ACYPI001090 GB19444 AGAP000500 AAEL014689 AAEL003349 PB23544 PHUM101680 GLEAN_12437
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	15850 y1 w67c23; P{EPgy2}CprEY02046 21848 y1 w67c23; P{Mae-UAS.6.11}CprDP01397 36335 w*; CyO, P{Tb1}CprCyO-A/snaSco
Harvard	- P{XP}Cprd02317 - PBac{RB}Cpre01125
Kyoto	123352 w1118; P{RS3}CprCB-0872-3
VDRC	v107422 P{KK102823}VIE-260B v44232 w1118; P{GD945}v44232/CyO v44233 w1118; P{GD945}v44233/TM3 v46715 w1118; P{GD945}v46715/TM3
Genomic Clones ( 1 )
	BACR05J04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 192 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH28443 LD46590
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT07173 GH01954 GH02682 GH02683 GH02684 GH04583 GH07050 GH19111 HL02055 HL03449 HL04239 LD03981 LD03983 LD04005 LD06435 LD08818 LD10302 LD10321 LD11751 LD14531 LD14632 LD15221 LD16217 LD19056 LD20032 LD24160 LD25725 LD28523 LD28875 LD30484 LD32703 LD33882 LD37205 LD42205 LD42302 LD42817 LD44362 LD44473 LD44552 LD46515 LD46595 LD46992 LD48032 LP16945 RE07349 RE08575 RE09673 RE09872 RE13974 RE17791 RE24993 RE27737 RE30203 RE31920 RE35219 RE37028 RE37078 RE39177 RE53409 RE53570 RE54510 RE56782 RE57234 RE60947 RE66453 RE68528 RE71295 RE72633 RE74126 RE74716 SD02752 SD11851 SD15033 SD17212 SD22358 SD28290
Other clones	38552 50411 81616 527725 bs21f05 Dmel_dig_016660_0718_0547 Dmel_dig_019378_0599_1098 Dmel_neb_007042_0687_1425 Dmel_neb_010976_0410_0331 Dmel_neb_012969_0090_2935 Dmel_neb_013080_0173_3522 Dmel_neb_013721_0129_2998 Dmel_neb_013801_0087_0806 Dmel_neb_013851_0327_3340 Dmel_neb_013859_0112_2578 Dmel_neb_014207_0164_2445 Dmel_neb_014461_0127_2747 Dmel_neb_014838_0155_1895 Dmel_neb_015094_0145_1608 Dmel_neb_015253_0444_2076 Dmel_neb_015328_0377_1488 Dmel_neb_015464_0409_0818 Dmel_neb_015647_0208_0587 EK151136 EK160349 EK176461 EK199361 EK262728 EK307009 EN01739 EN01838 EN07831 EN11213 EP09415 GH27812 RP01516 RP001000164 RP001000403 RP001000867 RP001001166 RP001001280 RP001002076 RP001004104 RP001005188 RP001005243 RP001006545 RP001006800 RP001007029 RP001007202 RP001009228 RP001009822 RP001010277 RP001010626 RP001010977 RP001011550 RP001011671 RP001011995 RP001012375 RP001012495 RP001013651 RP001013800 RP001016430 RP001017099 RP001017190 RP001019490 RP001019721 RP001019781 RP001021402 RP001021522 RP001022167 RP001022627 RP001022778 RP001024213 RP001024774 RP001025324 RP001027584 RP001027863 RP001028718 RP001028860 RP001031341 RP001032532 RP001032684 RP001032688 RP001033492 RP001034031 RP001034866 RP001035443 RP001035693 RP001036298 RP001036454 RP001037119 RP001038068 RP001038479 RP001040587 RP001040668 RP001040826 RP001042134 RP001043036 RP001043535 RP001044361 RP001045133 RP001046061 RP001046153 RP001047670 RP001048316 RP001049093 RP001049325 RP001049858 RP001051107 RP001051575 RP001056513 RP001056609 SD25241 UUGC0957
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0015623 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33883
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	Pez mutants that lack detectable Pez protein and flies carrying overlapping deletions for Pez are viable. The putative lethal Pez mutants reported in FBrf0146134 were subsequently found to map to Cpr, the adjacent gene, and do not affect Pez. (Edwards, 2008.7.1) Identified as a gene with significant level of mRNA cycling as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day. (McDonald and Rosbash, 2001) Cpr gene structure and expression patterns are studied. The putative amino acid sequence shows strong homology to the reductase of the housefly and to a lesser extent to that of yeast and vertebrates. High levels of expression in adult antenna may reflect an involvement in clearing functions in the process of olfaction. (Hovemann et al., 1997)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057810 NM_164689 RefSeq (Proteins) • NP_477158 NP_723173 DDBJ / EMBL / GenBank • AAF52367 AAK93424 AAN10585 AC004568 AC005285 AC093100 AI514950 AI946162 AW943855 AY052000 CAA63639 CZ472744 CZ474385 CZ475264 CZ478944 X93090 Entrez Gene - A searchable database of RefSeq genes. • 33883 UniProtKB/Swiss-Prot • Q27597 UniProtKB/TrEMBL • Q8IPJ7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Oxidoreductase FAD/NAD(P)-binding (IPR001433) Flavoprotein pyridine nucleotide cytochrome reductase (IPR001709) FAD-binding, type 1 (IPR003097) Flavodoxin/nitric oxide synthase (IPR008254) Ferredoxin reductase-type FAD-binding domain (IPR017927) Riboflavin synthase-like beta-barrel (IPR017938) Flavodoxin (IPR001094) NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain-3 (IPR023173) NADPH-cytochrome P450 reductase (IPR023208)
Linkouts
	BioGRID - A database of protein and genetic interactions • 60040 DroID - A comprehensive database of gene and protein interactions. • FBgn0015623 DRSC - Results from RNAi screens. • FBgn0015623 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015623 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11567-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0015623 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33883 InParanoid A subset of ortholog calls from InParanoid. • AAEL003349-PA Aedes aegypti (mosquito) AGAP000500-PA Anopheles gambiae (mosquito) XP_001119949.1 Apis mellifera (honey bee) XP_001945312.1 Acyrthosiphon pisum (pea aphid) At4g24520.1 Arabidopsis thaliana (wall cress) 34195 Batrachochytrium dendrobatidis (chytrid fungus) 287024 Branchiostoma floridae (lancelet) 288748 Branchiostoma floridae (lancelet) XP_001899759.1 Brugia malayi (roundworm nematode) BGIBMGA006837-PA Bombyx mori (silk worm) ENSBTAP00000022718 Bos taurus (bovine) CAL0003511 Candida albicans (a form of yeast) CN20142 Caenorhabditis brenneri (small nematode) CBP00963 Caenorhabditis briggsae (nematode) CE02018 Caenorhabditis elegans (worm) ENSCAFP00000019835 Canis familiaris (dog) CAGL0D04114g Candida glabrata (haploid yeast) Chro.40304 Cryptosporidium hominis (obligate parasite) ENSCINP00000017605 Ciona intestinalis (sea squirt) JA05425 Caenorhabditis japonica (nematode) CMR440C Cyanidioschyzon merolae (red alga) cn04505 Cryptococcus neoformans (yeast-like fungus) cgd4_2700 Cryptosporidium parvum (protozoan parasite) CPIJ014664 Culex pipens (mosquito) ENSCPOP00000005592 Cavia porcellus (guinea pig) 116375 Chlamidomonas reinhardtii (green alga) RP27249 Caenorhabditis remanei (nematode) ENSCSAVP00000005677 Ciona savignyi (sedentary tunicate) 173459 Capitella spl (polychaete worm) DDB0266665 Dictyostelium discoideum (amoeba) DEHA2G17578g Debaryomyces Hansenii (yeast) 300447 Daphnia pulex (daphnia) ENSDARP00000017908 Danio rerio (zebra fish) ENSECAP00000007060 Equus caballus (horse) NP_417244.1 Escherichia coli K12 (bacteria) ENSGACP00000010198 Gymnopilus aculeatus (mushroom) ENSGALP00000003187 Gallus gallus (chicken) GL50803_15897 Giardia lamblia (flagellated protozoan) 113572 Hypsipyla robusta (cedar shoot borer) ENSP00000265302 Homo sapiens (human) ISCW020316-PA Ixodes scapularis (deer tick) KLLA0D08712g Kluyveromyces lactis (yeast) 187717 Lottia gigantea (owl limpet) LmjF28.1240 Leishmania major (virus) 16143 Monocosta brevicollis (choanoflagellate) ENSMODP00000028496 Monodelphis domestica (gray opossum) ENSMMUP00000026433 Macaca mulatta (rhesus monkey) ENSMUSP00000005651 Mus musculus (house mouse) 187451 Nematostella vectensis (starlet anemone) ENSOANP00000018353 Ornithorynchus anatinus (platypus) ENSORLP00000014273 Oryzias latipes (japanese killifish) LOC_Os09g38620.1 Oryza sativa (asian rice) 14922 Ostreococcus tauri (green alga) PFI1140w Plasmodium falciparum (protozoal parasite) PHUM000248-PA Pediculus humanus (human body louse) 201169 Physcomitrella patens (moss) ENSPPYP00000019589 Pongo pygmaeus (orangutan) 71492 Phytophthora ramorum (sudden oak death pathogen) 142875 Phytophthora sojae (root rot pathogen) 818445 Populus trichocarpa (black cottonwood) ENSPTRP00000033034 Pan troglodytes (chimpanzee) PVX_099570 Plasmodium vivax (protozoal parasite) ENSRNOP00000001961 Rattus norvegicus (norway rat) 5051622 Sorghum bicolor (sorghum) YHR042W Saccharomyces cerevisiae (budding yeast) Smp_030760 Schistosoma mansoni (trematode parasite) SPBC29A10.01 Schizosaccharomyces pombe (fission yeast) XP_799192.2 Strongylocentrotus purpuratus (purple sea urchin) 63169 Trichoplax adhaerens (metazoa) TA05915 Theileria annulata (apicomplexan parasite) XP_971174.1 Tribolium castaneum (red flour beetle) Tc00.1047053506585.70 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000006669 Tetraodon nigroviridis (green spotted pufferfish) TP03_0092 Theileria parva (parasitic protozoan) 264678 Thalassiosira pseudonana (marine diatom) ENSTRUP00000018392 Takifugu rubripes (pufferfish Takifugu) 196.m00061 Tetrahymena thermophila (ciliate protozoa) 84843.m00225 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000019690 Xenopus tropicalis (frog) YALI0D04422g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33883 modMine - Data generated by the modENCODE project. • FBgn0015623 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • LH22946 ISCW020316 FBgn0231454 FBgn0216760 FBgn0200041 FBgn0194788 FBgn0173527 JGI_V11_300447 FBgn0071124 FBgn0163105 FBgn0134291 FBgn0118220 FBgn0102714 FBgn0091543 CPIJ014664 BGIBMGA006837 ACYPI001593 ACYPI001090 GB19444 AGAP000500 AAEL014689 AAEL003349 PB23544 PHUM101680 GLEAN_12437
Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym	CCR (Khanna et al., 2010) CG11567 (Keleman et al., 2009.8.5, Cammarato et al., 2011) cpr (Hovemann, 1995.11.16, ) CPR (Hovemann et al., 1997) Cpr (Beller et al., 2006, Lee et al., 2002, Edwards, 2008.7.1, Gan et al., 2010, Lattao et al., 2011) DmCPR (Zhang et al., 2004) DMR (Helvig et al., 2004) NCPR (Mushegian et al., 1998) P450 (Morton, 1993, Ahrens et al., 2007)
Name Synonym	Cytochrome c reductase (NADPH) (Khanna et al., 2010) Cytochrome P450 reductase (Cammarato et al., 2011, Lattao et al., 2011) NADPH-cytochrome P450 oxidoreductase   P450 reductase (Scott, 1999, Helvig et al., 2004)
Secondary FlyBase IDs
References ( 40 )
Generate a list of	All references relating to this gene ( 40 )
List References by type	Research paper  ( 13 ) Supplementary material  ( 6 ) Review  ( 3 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 2 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 )
Recent research papers ( 3 )
	Lattao et al., 2011, Fly 5(4): 369--370 Tubby-tagged balancers for the Drosophila X and second chromosomes. [FBrf0216878] Gan et al., 2010, Cell Res. 20(7): 763--783 Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq. [FBrf0211191] Khanna et al., 2010, BMC Genomics 11(1): 302 Towards a membrane proteome in Drosophila: a method for the isolation of plasma membrane. [FBrf0210923] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...