FB2020_02, released Apr 14, 2020

Gene: Dmel\p38a

Open Close
General Information
Symbol
Dmel\p38a
Species
D. melanogaster
Name
p38a MAP kinase
Annotation Symbol
CG5475
Feature Type
protein_coding_gene
FlyBase ID
FBgn0015765
Gene Model Status
Current
Stock Availability
10 publicly available
Enzyme Name (EC)
Mitogen-activated protein kinase (2.7.11.24)
Gene Snapshot
p38a MAP kinase (p38a) encodes a member of the mitogen-activated protein kinases responsive to diverse stresses. In immune response, it activates its downstream component encoded by Atf-2 that in turn regulates Duox expression. [Date last reviewed: 2019-03-14]
Other Summaries
Also Known As

p38, Mpk2, D-p38a, p38 MAPK, Erk2

Key Links
Genomic Location
Cytogenetic map
95E5-95E5
Sequence location
3R:24,150,416..24,152,321 [-]
Recombination map

3-83

RefSeq locus
NT_033777 REGION:24150416..24152321
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. (O62618)
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
MAP kinase activity
Predictions / Assertions
ATP binding; MAP kinase activity; SAP kinase activity
Catalytic Activity (EC)
Experimental Evidence
ATP + a protein = ADP + a phosphoprotein (2.7.11.24)
Predictions / Assertions
ATP + a protein = ADP + a phosphoprotein (2.7.11.24)
Summaries
Gene Group (FlyBase)
CONVENTIONAL MITOGEN ACTIVATED PROTEIN KINASES -
Conventional Mitogen-activated protein kinases (MAPK) are proline-directed protein serine/threonine kinases that are components of the MAPK signaling cascade. MAPKs are activated by dual phosphorylation on Thr and Tyr residues within a conserved Thr-X-Tyr motif located in the activation loop by MAPK kinases. (Adapted from PMID:21372320).
Protein Function (UniProtKB)
Kinase involved in a signal transduction pathway. May down-regulate insect immunity gene expression after prolonged infection.
(UniProt, O62618)
Summary (Interactive Fly)

p38a serine/threonine protein kinase - involved in response stress including heat shock, oxidative stress and starvation - activates its downstream component Atf-2 that in turn regulates Duox expression

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\p38a or the JBrowse view of Dmel\p38a for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
p38a-RA
FBtr0084580
NM_057815
1450
366
p38a-RB
FBtr0084581
NM_170126
1634
366
p38a-RC
FBtr0300572
NM_001170240
1474
366
Additional Transcript Data and Comments
Reported size (kB)

1.438 (longest cDNA)

(Han et al., 1998)

1.441 (longest cDNA)

(Han et al., 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
p38a-PA
FBpp0083965
42.3
366
6.84
NP_477163
AAF56244
p38a-PB
FBpp0083966
42.3
366
6.84
NP_732959
AAN13984
p38a-PC
FBpp0289799
42.3
366
6.84
NP_001163711
ACZ95005
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

366 aa isoforms: p38a-PA, p38a-PB, p38a-PC
Additional Polypeptide Data and Comments
Reported size (kDa)

366 (aa); 42 (kD predicted)

(Han et al., 1998)

366 (aa)

(Han et al., 1998)
Comments
External Data
Domain

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

(UniProt, O62618)
Post Translational Modification

Dually phosphorylated on Thr-184 and Tyr-186, which activates the enzyme.

(UniProt, O62618)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\p38a using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (27 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
MAP kinase activity
inferred from genetic interaction with SGD:S000004103
(Han et al., 1998)
inferred from direct assay
(Han et al., 1998)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
ATP binding
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
MAP kinase activity
inferred from biological aspect of ancestor with PANTHER:PTN002372889
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with HGNC:6876
(Han et al., 1998)
SAP kinase activity
traceable author statement
(Martin-Blanco, 2000)
Biological Process (22 terms)
Terms Based on Experimental Evidence (20 terms)
CV Term
Evidence
References
cellular response to arsenic-containing substance
inferred from direct assay
(Ryabinina et al., 2006)
cellular response to cadmium ion
inferred from direct assay
(Ryabinina et al., 2006)
cellular response to reactive oxygen species
inferred from direct assay
(Ryabinina et al., 2006)
defense response to bacterium
inferred from mutant phenotype
(Chen et al., 2010, Shinzawa et al., 2009)
defense response to fungus
inferred from mutant phenotype
(Chen et al., 2010)
determination of adult lifespan
inferred from mutant phenotype
(Vrailas-Mortimer et al., 2011)
heart morphogenesis
inferred from genetic interaction with FLYBASE:p38b; FB:FBgn0024846
(Lim et al., 2014)
immune response
inferred from direct assay
(Han et al., 1998)
MAPK cascade
inferred from direct assay
(Han et al., 1998)
mucosal immune response
inferred from mutant phenotype
(Ha et al., 2009)
negative regulation of antimicrobial humoral response
inferred from mutant phenotype
(Han et al., 1998)
paracrine signaling
inferred from genetic interaction with FLYBASE:p38b; FB:FBgn0024846
(Lim et al., 2014)
positive regulation of cell size
inferred from genetic interaction with FLYBASE:p38b; FB:FBgn0024846
(Cully et al., 2010)
regulation of adult chitin-containing cuticle pigmentation
inferred from genetic interaction with FLYBASE:Ask1; FB:FBgn0014006
(Sekine et al., 2011)
regulation of cellular response to oxidative stress
inferred from mutant phenotype
(Vrailas-Mortimer et al., 2011)
response to heat
inferred from mutant phenotype
(Gonda et al., 2012, Cai et al., 2011, Cully et al., 2010)
response to hydrogen peroxide
inferred from mutant phenotype
(Cully et al., 2010)
response to osmotic stress
inferred from direct assay
(Han et al., 1998)
inferred from mutant phenotype
(Cai et al., 2011)
response to oxidative stress
inferred from mutant phenotype
(Cai et al., 2011)
response to starvation
inferred from mutant phenotype
(Cai et al., 2011, Cully et al., 2010)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
intracellular signal transduction
inferred from biological aspect of ancestor with PANTHER:PTN000622075
(assigned by GO_Central )
(Gaudet et al., 2011)
MAPK cascade
non-traceable author statement
(Martin-Blanco, 2000)
inferred from sequence or structural similarity with HGNC:6876
(Han et al., 1998)
regulation of gene expression
inferred from biological aspect of ancestor with PANTHER:PTN000622075
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
nucleus
inferred from direct assay
(Han et al., 1998)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000622075
(assigned by GO_Central )
(Gaudet et al., 2011)
nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000622075
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic midgut chamber
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
embryonic stage 2
organism | ubiquitous
(Han et al., 1998)
embryonic stage 13
embryonic primordium of adult hindgut precursor
(Han et al., 1998)
Additional Descriptive Data

p38a transcripts are detected predominantly in preblastoderm embryos by in situ hybridization. In late embryos, a low level of staining is observed in the posterior region. Transcripts are detected at a low level throughout development on northern blots.

(Han et al., 1998)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
nucleus
inferred from direct assay
(Han et al., 1998)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\p38a in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 4 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 15 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of p38a
Transgenic constructs containing regulatory region of p38a
Deletions and Duplications ( 4 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (10)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\MAPK14
13 of 15
Yes
No
 
Hsap\MAPK11
12 of 15
No
Yes
Hsap\MAPK13
6 of 15
No
Yes
 
Hsap\MAPK12
5 of 15
No
Yes
Hsap\MAPK1
2 of 15
No
No
Hsap\MAPK3
2 of 15
No
No
 
Hsap\MAPK7
2 of 15
No
No
Hsap\MAPK4
1 of 15
No
No
Hsap\MAPK6
1 of 15
No
No
Hsap\MAPK15
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (10)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Mapk14
13 of 15
Yes
No
Mmus\Mapk11
12 of 15
No
Yes
Mmus\Mapk13
6 of 15
No
Yes
Mmus\Mapk12
4 of 15
No
Yes
Mmus\Mapk1
2 of 15
No
No
Mmus\Mapk3
2 of 15
No
No
Mmus\Mapk7
2 of 15
No
No
Mmus\Mapk4
1 of 15
No
No
Mmus\Mapk6
1 of 15
No
No
Mmus\Mapk15
1 of 15
No
No
Rattus norvegicus (Norway rat) (11)
Rnor\Mapk14
12 of 13
Yes
No
Rnor\Mapk11
11 of 13
No
Yes
Rnor\Mapk13
6 of 13
No
Yes
Rnor\Mapk12
5 of 13
No
Yes
Rnor\LOC100912585
2 of 13
No
Yes
Rnor\Mapk1
2 of 13
No
No
Rnor\Mapk7
2 of 13
No
Yes
Rnor\Mapk3
1 of 13
No
No
Rnor\Mapk4
1 of 13
No
No
Rnor\Mapk6
1 of 13
No
No
Rnor\Mapk15
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (10)
Xtro\mapk11
11 of 12
Yes
Yes
Xtro\mapk14
7 of 12
No
No
Xtro\mapk12
5 of 12
No
Yes
Xtro\LOC100145045
4 of 12
No
Yes
Xtro\mapk1
2 of 12
No
No
Xtro\mapk7
2 of 12
No
Yes
Xtro\mapk13
2 of 12
No
Yes
Xtro\mapk4
1 of 12
No
No
Xtro\mapk6
1 of 12
No
No
Xtro\mapk15
1 of 12
No
No
Danio rerio (Zebrafish) (13)
Drer\mapk11
12 of 15
Yes
Yes
Drer\mapk14a
12 of 15
Yes
No
Drer\mapk14b
11 of 15
No
No
Drer\mapk12b
6 of 15
No
Yes
Drer\mapk13
6 of 15
No
No
Drer\mapk12a
5 of 15
No
Yes
Drer\zgc:171775
4 of 15
No
Yes
Drer\mapk1
2 of 15
No
No
Drer\mapk3
2 of 15
No
No
Drer\mapk7
2 of 15
No
No
Drer\mapk4
1 of 15
No
No
Drer\mapk6
1 of 15
No
No
Drer\mapk15
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (13)
Cele\pmk-1
14 of 15
Yes
No
Cele\pmk-2
7 of 15
No
Yes
Cele\F09C12.2
2 of 15
No
Yes
Cele\mpk-1
2 of 15
No
No
Cele\mpk-2
2 of 15
No
Yes
Cele\pmk-3
2 of 15
No
Yes
Cele\cdk-4
1 of 15
No
No
Cele\gska-3
1 of 15
No
Yes
Cele\kgb-1
1 of 15
No
No
Cele\kgb-2
1 of 15
No
No
Cele\mapk-15
1 of 15
No
No
Cele\sma-5
1 of 15
No
No
Cele\Y106G6E.1
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (22)
Atha\MPK3
4 of 9
Yes
No
Atha\MPK6
3 of 9
No
No
Atha\MPK10
3 of 9
No
No
Atha\ATMPK13
2 of 9
No
No
Atha\MPK1
2 of 9
No
No
Atha\MPK2
2 of 9
No
No
Atha\MPK4
2 of 9
No
No
Atha\MPK5
2 of 9
No
No
Atha\MPK7
2 of 9
No
No
Atha\MPK11
2 of 9
No
No
Atha\MPK12
2 of 9
No
No
Atha\MPK14
2 of 9
No
No
Atha\MPK19
2 of 9
No
No
Atha\AT3G63340
1 of 9
No
Yes
Atha\AT4G01595
1 of 9
No
Yes
Atha\ATMPK8
1 of 9
No
No
Atha\MPK9
1 of 9
No
No
Atha\MPK15
1 of 9
No
No
Atha\MPK16
1 of 9
No
No
Atha\MPK17
1 of 9
No
No
Atha\MPK18
1 of 9
No
No
Atha\MPK20
1 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (9)
Scer\HOG1
11 of 15
Yes
No
Scer\SLT2
4 of 15
No
No
Scer\FUS3
3 of 15
No
No
Scer\KDX1
3 of 15
No
No
Scer\KSS1
3 of 15
No
No
Scer\SMK1
2 of 15
No
No
Scer\CMK1
1 of 15
No
No
Scer\SGV1
1 of 15
No
No
Scer\SNF1
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (3)
Spom\sty1
9 of 12
Yes
No
Spom\pmk1
2 of 12
No
No
Spom\spk1
2 of 12
No
No
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091909LN )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila simulans
Dsim\GD18318
Drosophila sechellia
Dsec\GM23508
Drosophila erecta
Dere\GG12369
Drosophila yakuba
Dyak\GE10824
Drosophila ananassae
Dana\GF18893
Drosophila pseudoobscura pseudoobscura
Dpse\GA18909
Drosophila persimilis
Dper\GL24141
Drosophila willistoni
Dwil\GK11930
Drosophila virilis
Dvir\GJ14531
Drosophila mojavensis
Dmoj\GI23428
Drosophila grimshawi
Dgri\GH19092
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915068V )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17007003
Glossina morsitans
Tsetse fly
Gmor\GMOY009517
Glossina morsitans
Tsetse fly
Gmor\GMOY010566
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_06267
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_09322
Mayetiola destructor
Hessian fly
Mdes\Mdes006309
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL008379
Anopheles darlingi
American malaria mosquito
Adar\ADAC007034
Anopheles gambiae
Malaria mosquito
Agam\AGAP012148
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ002175
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ002174
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W06A2 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA003561
Danaus plexippus
Monarch butterfly
Dple\DPOGS215664-PA
Apis florea
Little honeybee
Aflo\2170885620
Apis mellifera
Western honey bee
Amel\GB43914
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP23700
Bombus terrestris
Buff-tailed bumblebee
Bter\15207231
Linepithema humile
Argentine ant
Lhum\LH18113
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001409
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG000447
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_09204
Tribolium castaneum
Red flour beetle
Tcas\TC013594
Pediculus humanus
Human body louse
Phum\PHUM390460
Rhodnius prolixus
Kissing bug
Rpro\RPRC003276
Cimex lectularius
Bed bug
Clec\CLEC003486
Cimex lectularius
Bed bug
Clec\CLEC003487
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI081647
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI010107
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_02213
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X065J )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR015480
Ixodes scapularis
Black-legged tick
Isca\ISCW021966
Stegodyphus mimosarum
African social velvet spider
Smim\KFM65231.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g00790
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_205212
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G08QL )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Mapk15_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-P38mapk_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_021583gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Erk1/2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Mapk15_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hypp_2810
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Mapk15
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000007067
Ciona intestinalis
Vase tunicate
Cint\erk5
Ciona intestinalis
Vase tunicate
Cint\LOC100184138
Gallus gallus
Domestic chicken
Ggal\MAPK1
Gallus gallus
Domestic chicken
Ggal\MAPK15
Gallus gallus
Domestic chicken
Ggal\MAPK14
Gallus gallus
Domestic chicken
Ggal\MAPK13
Gallus gallus
Domestic chicken
Ggal\MAPK12
Gallus gallus
Domestic chicken
Ggal\MAPK11
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (10)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
p38b
9 of 10
p38c
5 of 10
Erk7
4 of 10
rl
4 of 10
bsk
2 of 10
CG8565
2 of 10
CG42366
2 of 10
nmo
2 of 10
SRPK
2 of 10
Srpk79D
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
MAPK14; mitogen-activated protein kinase 14
13 of 15
600289
       
      MAPK11; mitogen-activated protein kinase 11
      12 of 15
      602898
          MAPK13; mitogen-activated protein kinase 13
          6 of 15
          602899
               
              MAPK12; mitogen-activated protein kinase 12
              5 of 15
              602399
                  Functional Complementation Data
                  Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                  Interactions
                  Summary of Physical Interactions
                  esyN Network Diagram
                  Show neighbor-neighbor interactions:
                  Select Layout:
                  Legend:
                  Protein
                  RNA
                  Selected Interactor(s)
                  Interactions Browser
                  View in Interactions Browser
                  Please see the Physical Interaction reports below for full details
                  protein-protein
                  Physical Interaction
                  Assay
                  References
                  p38a - CG10418
                  anti tag coimmunoprecipitation, peptide massfingerprinting
                  (Belozerov et al., 2012)
                  p38a - CG1092
                  anti tag coimmunoprecipitation, peptide massfingerprinting
                  (Belozerov et al., 2012)
                  p38a - CG16935
                  anti tag coimmunoprecipitation, peptide massfingerprinting
                  (Belozerov et al., 2012)
                  p38a - CG2852
                  anti tag coimmunoprecipitation, peptide massfingerprinting
                  (Belozerov et al., 2012)
                  p38a - CG31800
                  anti tag coimmunoprecipitation, peptide massfingerprinting
                  (Belozerov et al., 2012)
                  p38a - CG33129
                  anti tag coimmunoprecipitation, peptide massfingerprinting
                  (Belozerov et al., 2012)
                  p38a - CG6617
                  anti tag coimmunoprecipitation, peptide massfingerprinting
                  (Belozerov et al., 2012)
                  p38a - CG9372
                  anti tag coimmunoprecipitation, peptide massfingerprinting
                  (Belozerov et al., 2012)
                  p38a - CG9586
                  anti tag coimmunoprecipitation, peptide massfingerprinting
                  (Belozerov et al., 2012)
                  p38a - Jra
                  enzymatic study, autoradiography
                  (Han et al., 1998)
                  p38a - MAPk-Ak2
                  experimental knowledge based
                  (Guruharsha et al., 2011)
                  p38a - Npl4
                  anti tag coimmunoprecipitation, peptide massfingerprinting
                  (Belozerov et al., 2012)
                  p38a - Nup358
                  anti tag coimmunoprecipitation, peptide massfingerprinting
                  (Belozerov et al., 2012)
                  p38a - RfC4
                  anti tag coimmunoprecipitation, peptide massfingerprinting
                  (Belozerov et al., 2012)
                  p38a - p38b
                  experimental knowledge based
                  (Guruharsha et al., 2011)
                  p38a - ps
                  anti tag coimmunoprecipitation, peptide massfingerprinting
                  (Belozerov et al., 2012)
                  p38a - rad50
                  anti tag coimmunoprecipitation, peptide massfingerprinting
                  (Belozerov et al., 2012)
                  p38a - shi
                  anti tag coimmunoprecipitation, peptide massfingerprinting
                  (Belozerov et al., 2012)
                  Summary of Genetic Interactions
                  esyN Network Diagram
                  esyN Network Key:
                  Suppression
                  Enhancement
                  View in Interactions Browser
                  Please look at the allele data for full details of the genetic interactions
                  Starting gene(s)
                  Interaction type
                  Interacting gene(s)
                  Reference
                  p38a
                  suppressible
                  Duox
                  (Ha et al., 2009)
                  p38a
                  enhanceable
                  MAPk-Ak2
                  (Seisenbacher et al., 2011)
                  p38a|p38b
                  suppressible
                  Sod2
                  (Vrailas-Mortimer et al., 2011)
                  Starting gene(s)
                  Interaction type
                  Interacting gene(s)
                  Reference
                  Ask1
                  suppressible
                  p38a
                  (Sekine et al., 2011)
                  Cat
                  suppressible
                  p38a|p38b
                  (Lim et al., 2014)
                  Dhx15
                  suppressible
                  p38a
                  (Mosallanejad et al., 2014)
                  hiw
                  suppressible
                  p38a
                  (Klinedinst et al., 2013)
                  p38b
                  suppressible
                  p38a
                  (Seisenbacher et al., 2011)
                  slim
                  suppressible
                  p38a
                  (Sekine et al., 2012)
                  External Data
                  Linkouts
                  BioGRID - A database of protein and genetic interactions.
                  DroID - A comprehensive database of gene and protein interactions.
                  InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                  MIST (protein-protein) - An integrated Molecular Interaction Database
                  Pathways
                  Genomic Location and Detailed Mapping Data
                  Chromosome (arm)
                  3R
                  Recombination map

                  3-83

                  Cytogenetic map
                  95E5-95E5
                  Sequence location
                  3R:24,150,416..24,152,321 [-]
                  FlyBase Computed Cytological Location
                  Cytogenetic map
                  Evidence for location
                  95E5-95E5
                  Limits computationally determined from genome sequence between P{PZ}Syx1A06737&P{PZ}Syx1A10660 and P{PZ}crb07207&P{PZ}BRWD305842
                  Experimentally Determined Cytological Location
                  Cytogenetic map
                  Notes
                  References
                  95E4-95F1
                  (Han, 1997.11.21)
                  95E4-95F1
                  (determined by in situ hybridisation)
                  (Han et al., 1998)
                  Experimentally Determined Recombination Data
                  Location

                  3-83

                  (FlyBase, 2016)

                  3-82.7

                  (Comeron et al., 2012)

                  3-

                  (Martin-Blanco and Martinez Arias, 1997)
                  Left of (cM)
                  Right of (cM)
                  Notes
                  Stocks and Reagents
                  Stocks (10)
                  Genomic Clones (18)
                   

                  Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                  cDNA Clones (31)
                   

                  Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                  cDNA clones, fully sequences
                  BDGP DGC clones
                  Other clones
                  Drosophila Genomics Resource Center cDNA clones

                  For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                  cDNA Clones, End Sequenced (ESTs)
                  BDGP DGC clones
                  Other clones
                  RNAi and Array Information
                  Linkouts
                  DRSC - Results frm RNAi screens
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  Antibody Information
                  Laboratory Generated Antibodies
                   
                  Commercially Available Antibodies
                   
                  Cell Signaling Technology - Commercial vendor for primary antibodies and antibody conjugates.
                  Other Information
                  Relationship to Other Genes
                  Source for database identify of

                  Source for identity of: Mpk2 CG5475

                  (Kodira, 1999.11)

                  Source for identity of: p38a Mpk2

                  (FlyBase, 2009-)
                  Source for database merge of
                  Additional comments

                  Renamed from 'Mpk2' to 'p38a' to: i) make nomenclature consistent between p38 genes; ii) reflect the preferred usage in the literature; iii) reflect the preferred symbol used in the first peer-reviewed papers to characterize the gene (FBrf0100059, FBrf0102625).

                  (FlyBase, 2009-)

                  The p38a and p38b genes share at least 50% identity.

                  (Langille and Clark, 2007)

                  Relationship of "Mpk2" to "Erk-B" not known.

                  Other Comments

                  Null mutants are homozygous viable with no developmental defects, though show susceptibility to some environmental stresses including heat shock, oxidative stress and starvation. Immune response profile of Mpk2 mutants is largely normal.

                  (Craig et al., 2004)

                  Mpk2 activation in response to NaCl and heat shock is markedly reduced in Mekk1 mutants compared to wild type.

                  (Inoue et al., 2001)

                  Mekk1 regulation of the Mpk2/p38b pathway is critical for the response to environmental stresses.

                  (Inoue et al., 2001)

                  Mpk2 is cloned and sequenced from a neoplasmic l(2)mbn cell line. Study of the protein and its function reveals that similar osmotic stress-responsive signal transduction pathways are conserved in yeast, Drosophila and mammalian cells.

                  (Han et al., 1998)

                  Mpk2 partially functionally complements the function of S.cerevisiae Scer\HOG1 in a hyperosmotic environment.

                  (Han et al., 1998)

                  Mpk2 has been cloned and sequenced.

                  (Han et al., 1998)

                  Overexpression of Mpk2 suppresses the lipopolysaccharide induction of immunity genes.

                  (Han et al., 1998)
                  Origin and Etymology
                  Discoverer
                  Etymology
                  Identification
                  External Crossreferences and Linkouts ( 78 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                  UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                  Other crossreferences
                  BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                  Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                  Flygut - An atlas of the Drosophila adult midgut
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  InterPro - A database of protein families, domains and functional sites
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  modMine - A data warehouse for the modENCODE project
                  SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                  Linkouts
                  BioGRID - A database of protein and genetic interactions.
                  Cell Signaling Technology - Commercial vendor for primary antibodies and antibody conjugates.
                  Cell Signaling Technology - Commercial vendor for primary antibodies and antibody conjugates.
                  DPiM - Drosophila Protein interaction map
                  DroID - A comprehensive database of gene and protein interactions.
                  DRSC - Results frm RNAi screens
                  FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                  FlyMine - An integrated database for Drosophila genomics
                  Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                  InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                  KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                  MIST (protein-protein) - An integrated Molecular Interaction Database
                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                  Synonyms and Secondary IDs (36)
                  Reported As
                  Symbol Synonym
                  CG5475
                  (Hosono et al., 2015, Chen et al., 2012, Ni et al., 2011.7.19, Vrailas-Mortimer et al., 2011, Zhang et al., 2011, Ni et al., 2010.12.1, Zhang et al., 2010, Keleman et al., 2009.8.5, Morrison et al., 2000)
                  D-MPK2
                  (Martin-Blanco, 2000)
                  D-P38a
                  (Martin-Blanco, 2000)
                  D-p38
                  (Kurz and Ewbank, 2003)
                  D-p38 MAPK
                  (Ryabinina et al., 2006)
                  D-p38a
                  (Lim et al., 2019, Craig et al., 2004, Craig, 2003.12.16, Inoue et al., 2001, Stronach and Perrimon, 1999, Han et al., 1998)
                  DMPK2
                  (Martin-Blanco and Martinez Arias, 1996)
                  DmMPK2
                  (Takaesu et al., 1998)
                  Dmp38a
                  (Shinzawa et al., 2009)
                  Dp38
                  (Sun et al., 2008, Kim et al., 2002, Lee et al., 2000, Han et al., 1998)
                  Dp38a
                  (Mosallanejad et al., 2014, Sekine et al., 2012, Sekine et al., 2011)
                  ERK2
                  (Farkas et al., 2009)
                  Erk2
                  (Park et al., 2017, Turski et al., 2012, Moses et al., 2011)
                  MAPK-2
                  (Abolaji et al., 2015)
                  MAPK2
                  (Ecker et al., 2017, Olalekan Abolaji et al., 2014)
                  MPK2
                  (Trindade de Paula et al., 2016)
                  Mpk2
                  (Engel et al., 2019, Zirin et al., 2015, Gomez et al., 2012, Gonda et al., 2012, Vrailas-Mortimer et al., 2011, Perkins et al., 2009.8.10, Davis et al., 2008, Langille and Clark, 2007, Liu et al., 2007, Sackton et al., 2007, Morozova et al., 2006, Stanyon et al., 2004)
                  P38
                  (El Chamy et al., 2015, Sanyal et al., 2005)
                  dMPK2
                  (Martin-Blanco and Martinez Arias, 1997)
                  dp38
                  (Shimizu et al., 2008, Sano et al., 2005)
                  dp38a
                  (Tian et al., 2014, Shimizu et al., 2008)
                  group 2
                  (Biggs and Zipursky, 1992)
                  mpk2
                  (Yang et al., 2018, Pereira et al., 2014, Stergiopoulos et al., 2009)
                  p38
                  (Barata and Dick, 2020, Boulan et al., 2019, Hwang et al., 2019, de Paula et al., 2018, Hariharan and Serras, 2017, Jevtov et al., 2015, Valéria Soares de Araújo Pinho et al., 2014, Zemolin et al., 2014, Buchon et al., 2013, Di Cara et al., 2013, Lee and Brey, 2013, Seong et al., 2011, Ahamed et al., 2010, Balakireva et al., 2007, Cinnamon et al., 2007, Sackton et al., 2007, Sathyanarayana et al., 2003, Chen et al., 2002, Tanenbaum et al., 1999)
                  p38 MAPK
                  (Hegazi et al., 2019, Whon et al., 2017, Lee and Lee, 2014, Demontis et al., 2013)
                  p38 α
                  (Bjorklund et al., 2006, Muller et al., 2002)
                  p38A
                  (Na et al., 2013, Manning, 2001.10.11)
                  p38Ka
                  (Vrailas-Mortimer et al., 2014, Vrailas-Mortimer et al., 2011)
                  p38MAPK
                  (Batista et al., 2016)
                  p38a
                  (Bangi et al., 2019, Chai et al., 2019, Maier et al., 2019, Sun et al., 2019, Jordán-Álvarez et al., 2017, Keesey et al., 2017, Kenmoku et al., 2017, Terriente-Félix et al., 2017, Ashton-Beaucage et al., 2016, Lee et al., 2016, Schimizzi et al., 2016, Santabárbara-Ruiz et al., 2015, Belozerov et al., 2014, Chakrabarti et al., 2014, Lim et al., 2014, Sopko et al., 2014, Klinedinst et al., 2013, Gonda et al., 2012, Igboin et al., 2012, Cai et al., 2011, Mathew et al., 2011, Seisenbacher et al., 2011, Seong et al., 2011, Chen et al., 2010, Chen et al., 2010, Cully et al., 2010, Ha et al., 2009, Ha et al., 2009, Davis et al., 2008, Shimizu et al., 2008, Balakireva et al., 2006, Collins et al., 2006, Hsiao et al., 2001, Tootle and Rebay, 2001, Lemaitre, 2000.12.20, Morrison et al., 2000, Weber et al., 2000)
                  p38α
                  (Pereira et al., 2014)
                  Name Synonyms
                  Erk-kinase-like
                  Mpk2
                  p38 MAP kinase
                  (Balakireva et al., 2007, Harrison et al., 2006)
                  p38 mitogen-activated protein kinase
                  (Di Cara et al., 2013, Balakireva et al., 2006)
                  p38a MAP kinase
                  (Han, 1997.11.21, Han, 1997.11.21)
                  stress-activated kinase P38
                  (Martin-Blanco et al., 1998)
                  Secondary FlyBase IDs
                  • FBgn0013952
                  • FBgn0022991
                  Datasets (0)
                  Study focus (0)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  References (172)