p38, Mpk2, D-p38a, p38 MAPK, Dp38
p38a serine/threonine protein kinase - involved in response stress including heat shock, oxidative stress and starvation - activates its downstream component Atf-2 that in turn regulates Duox expression
Please see the JBrowse view of Dmel\p38a for information on other features
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Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.47
1.438 (longest cDNA)
1.441 (longest cDNA)
366 (aa); 42 (kD predicted)
366 (aa)
Dually phosphorylated on Thr-184 and Tyr-186, which activates the enzyme.
The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\p38a using the Feature Mapper tool.
Comment: maternally deposited
p38a transcripts are detected predominantly in preblastoderm embryos by in situ hybridization. In late embryos, a low level of staining is observed in the posterior region. Transcripts are detected at a low level throughout development on northern blots.
GBrowse - Visual display of RNA-Seq signals
View Dmel\p38a in GBrowse 23-83
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Mpk2 CG5475
Source for identity of: p38a Mpk2
Renamed from 'Mpk2' to 'p38a' to: i) make nomenclature consistent between p38 genes; ii) reflect the preferred usage in the literature; iii) reflect the preferred symbol used in the first peer-reviewed papers to characterize the gene (FBrf0100059, FBrf0102625).
Relationship of "Mpk2" to "Erk-B" not known.
Null mutants are homozygous viable with no developmental defects, though show susceptibility to some environmental stresses including heat shock, oxidative stress and starvation. Immune response profile of Mpk2 mutants is largely normal.
Mpk2 partially functionally complements the function of S.cerevisiae Scer\HOG1 in a hyperosmotic environment.
Mpk2 has been cloned and sequenced.
Overexpression of Mpk2 suppresses the lipopolysaccharide induction of immunity genes.