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Gene Dmel\NetB

General Information
Symbol	Dmel\NetB	Species	D. melanogaster
Name	Netrin-B	Annotation symbol	CG10521
Feature type	protein_coding_gene	FlyBase ID	FBgn0015774
Gene Model Status	Current	Stock availability	18 publicly available
Also Known As	CT29512
Genomic Location
Chromosome (arm)	X	Recombination map	1-
Cytogenetic map	12F2-12F3	Sequence location	X:14,580,071..14,643,409 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Netrin-B is referred to in FlyBase by the symbol Dmel\NetB (CG10521, FBgn0015774). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: motor neuron axon guidance; synaptic target recognition; salivary gland boundary specification; axon guidance; glial cell migration; regulation of photoreceptor cell axon guidance; dendrite guidance. 32 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; organ system; peripheral nervous system; adult segment; multicellular structure; cell part; adult; external compound sense organ; embryonic foregut; non-connected developing system; larval abdominal segment; axon. It has 7 annotated transcripts and 7 annotated polypeptides. Protein features are: EGF-like, laminin; Laminin, N-terminal; Netrin domain; Netrin module, non-TIMP type; Tissue inhibitor of metalloproteinases-like, OB-fold. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye. Comments on Affy2 ProbeSet: ProbeSet 1636954_at completely aligns to an exonic region common to each of the 4 FlyBase-annotated transcript isoforms of NetB. Gene sequence location is X:14580071..14643409.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 12F2-12F3   Limits computationally determined from genome sequence between P{EP}EP1599 and P{EP}EP334&P{EP}EP977
Experimentally Determined Cytological Location
Cytogenetic map Notes References 12F1-12F1     (Mitchell, 1996.6.10) 12F1-12F2     (Harris, 1996.7.13) 12E10-12E10   (determined by in situ hybridisation)   (Mitchell et al., 1996) 12F1-12F2   (determined by in situ hybridisation)   (Harris et al., 1996)
Experimentally Determined Recombination Data
Location	1- (Mitchell et al., 1994, Mitchell et al., 1996, Harris, 1996.7.13, Mitchell, 1996.6.10)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\NetB for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45 Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) NetB-RA FBtr0073940  NM_078600   6505   793 NetB-RB FBtr0302016  NM_001169282   6412   793 NetB-RC FBtr0302017  NM_001169283   6415   793 NetB-RD FBtr0302018  NM_001169284   7926   793 NetB-RE FBtr0304874  NM_001258739   6418   793 NetB-RF FBtr0304875  NM_001258740   6355   793 NetB-RG FBtr0331596  NM_001272617   6391   785
Additional Transcript Data & Comments
Reported size (kB)	8.3 (northern blot) (Harris et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein NetB-PA   FBpp0073757   87.1   793   7.58     NP_511155   AAF48382 NetB-PB   FBpp0291226   87.1   793   7.58     NP_001162753   ACZ95288 NetB-PC   FBpp0291227   87.1   793   7.58     NP_001162754   ACZ95289 NetB-PD   FBpp0291228   87.1   793   7.58     NP_001162755   ACZ95290 NetB-PE   FBpp0293414   87.1   793   7.58     NP_001245668   AFH07382 NetB-PF   FBpp0293415   87.1   793   7.58     NP_001245669   AFH07383 NetB-PG   FBpp0303986   86.3   785   7.42     NP_001259546   AGB95388
Additional Polypeptide Data & Comments
Reported size (kDa)	793 (aa) (Mitchell et al., 1996, Harris et al., 1996)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Netrin module, non-TIMP type (IPR018933) Netrin domain (IPR001134) EGF-like, laminin (IPR002049) Laminin, N-terminal (IPR008211) Tissue inhibitor of metalloproteinases-like, OB-fold (IPR008993) Galactose-binding domain-like (IPR008979)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA140957   AA439960   AE014298 AAF48382   AE014298 ACZ95288   AE014298 ACZ95289   AE014298 ACZ95290   AE014298 AFH07382   AE014298 AFH07383   AE014298 AGB95388   AI113735   AI258427   AI260680   AJ570661   AJ570662   AJ570663   AJ570664   AJ570665   AJ570666   AJ570668   AJ570669   AJ570670   AJ570671   AJ570672   AJ570673   AJ570674   AJ570675   AJ570676   AJ570677   AJ570679   AJ570680   AJ570681   AJ570682   AJ570683   AJ570684   AJ570685   AJ570686   AJ570688   AJ570690   AJ570691   AJ570692   AJ570693   AJ570694   AJ570695   AJ570696   AJ570697   AJ570698   AJ570699   AJ570701   AJ570702   AJ570703   AJ570704   AJ570705   AJ570706   AJ570707   AJ570708   AJ570709   AJ570710   AJ570712   AJ570713   AJ570714   AJ889663   AJ889664   AJ889665   AJ889666   AJ889667   AJ889668   AJ889669   AJ889670   AJ889671   AJ889672   AJ889673   AJ889674   AJ889675   AJ889676   AJ889677   AJ889678   AJ889679   AJ889680   AJ889681   AJ889682   AJ889683   AJ889684   AJ889685   AJ889686   AJ889687   AJ889688   AJ889689   AJ889690   AJ889691   AJ889692   AJ889693   AJ889694   AJ889695   AJ889696   AJ889697   AJ889698   AJ889699   AJ889700   AJ889701   AJ889702   AJ889703   AJ889704   AJ889705   AJ889706   AJ889707   AJ889708   AJ889709   AJ889710   AJ889711   AJ889712   AJ889713   AJ889714   AJ889715   AJ889716   AJ889717   AJ889718   AJ889719   AW940350   AY060671 AAL28219   BG638070   BG639266   BH614898   BH840428   BI240290   BI567412   BI570723   BI571049   BI571822   BI572207   BI574571   BI575132   BI576078   BI582646   BI583275   BI583553   BI585502   BI585739   BI589113   BI590812   BI591477   BI610165   BI614301   BI615752   BP556093   CO262041   CO263956   CO265642   CO270669   CO271024   CO273993   CO279891   CO281115   CO283842   CO285936   CO288885   CO289183   CO289651   CO290069   CO291210   CO292519   CO304332   CO316886   CO323555   CO324997   CO345399   CZ471456   CZ471457   CZ471968   CZ473660   CZ481058   CZ484904   CZ484905   CZ486277   CZ488736   CZ488737   EC056898   EC058416   EC070664   EC074625   EC084295   EC084612   EC198102   EC198404   EC207654   EC208430   EC208724   EC209664   EC214685   EC219402   EC219512   EC223862   EC231462   EC233309   EC245038   EC247013   EC248553   EC249863   EC253996   GH941292   GH942211   GH943271   GH945672   GH945979   GH947678   GH947961   GH949636   GH951368   GH952274   GH953573   GH956234   GH956716   GH957514   GH958058   GH958827   GH959938   GH960812   GH962254   GH962860   GH963501   GH963748   GH964350   GH964805   GH964988   GH965574   GH965857   GH968407   GH971306   GH972002   GH972138   GH974421   GH974575   GH975724   GH977797   GH978246   GH981083   GH981439   GH981448   GH982289   GH984146   U60317 AAB17534   U63737 AAB17548
UniProtKB/Swiss-Prot	Q24568
UniProtKB/TrEMBL	E1JJP7 Q95SP5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   visceral mesoderm   (Mitchell et al., 1996) embryonic brain | restricted   (Mitchell et al., 1996) neuroblast MP2   (Mitchell et al., 1996) somatic mesoderm | restricted   (Mitchell et al., 1996) embryonic stage | early   mesoderm anlage   (Mitchell et al., 1996) embryonic stage 4 -- 6   mesoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi embryonic stage 7 -- 8   head mesoderm   (Fisher et al., 2012) mesectoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | segmentally repeated   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   central brain primordium   (Fisher et al., 2012) embryonic central brain glial cell   (Fisher et al., 2012) embryonic ganglion mother cell   (Fisher et al., 2012) embryonic neuroblast of ventral nerve cord primordium   (Fisher et al., 2012) lateral cord glial cell   (Fisher et al., 2012) lateral cord neuron   (Fisher et al., 2012) somatic muscle primordium   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) visceral muscle primordium   (Fisher et al., 2012) embryonic stage 12 -- 14   midline glial cell   (Mitchell et al., 1996) embryonic stage 12 -- 17   presumptive embryonic/larval nervous system | restricted   (Mitchell et al., 1996) embryonic stage 13 -- 14   wing disc | precursor   (Mitchell et al., 1996) embryonic stage 13 -- 16   circular visceral muscle fiber   (Fisher et al., 2012) dorsal head epidermis   (Fisher et al., 2012) embryonic brain   (Fisher et al., 2012) embryonic central brain glial cell   (Fisher et al., 2012) embryonic central brain neuron   (Fisher et al., 2012) embryonic head epidermis   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) embryonic/larval visceral muscle   (Fisher et al., 2012) lateral cord glial cell   (Fisher et al., 2012) lateral cord neuron   (Fisher et al., 2012) lateral cord surface glial cell   (Fisher et al., 2012) ventral midline   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) embryonic stage 14   MP1 neuron   (Mitchell et al., 1996) abdominal 2 ventral longitudinal muscle 3 -- abdominal 7 ventral longitudinal muscle 3   (Mitchell et al., 1996) abdominal 2 dorsal acute muscle 2 -- abdominal 7 dorsal acute muscle 2   (Mitchell et al., 1996) abdominal 2 ventral longitudinal muscle 4 -- abdominal 7 ventral longitudinal muscle 4   (Mitchell et al., 1996) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Harris et al., 1996) embryonic stage 12 -- 17   mesectoderm   (Harris et al., 1996) embryonic stage 13 -- 17   midline glial cell   (Harris et al., 1996)
Additional Descriptive Data
	NetB RNA is first detected in the developing CNS in early stage 12 embryos at which time it is observed in a subset of the cells along the midline and in a few cells lateral to the midline. In mid stage 12, expression decreases in the lateral cells and increases in the midline cells. By stage 13, it appears that the midline expression is limited to the midline glia. Midline expression continues to the end of embryogenesis. (Harris et al., 1996) NetB expression is first observed at the cellular blastoderm stage in the presumptive mesoderm and persists there through gastrulation and then fades. It continues to be expressed weakly in the visceral mesoderm and in small patches in the somatic mesoderm. NetB is expressed strongly in the ventral midline at stage 12 and 13 in the midline glia. It is also expressed in a dynamic pattern in subsets of CNS neurons and is expressed in many more neurons than is NetA. Among these are the MP neurons. NetB is expressed by dorsal muscle and by ventral muscles 6 and 7. It is expressed transiently at stages 13 and 14 in the embryonic precursors of the wing and haltere discs. Finally it is expressed in many cells in the brain and in some epidermal structures in the head that may be imaginal discs. (Mitchell et al., 1996)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   somatic mesoderm   (Harris et al., 1996) mesoderm   (Harris et al., 1996) embryonic/larval dorsal vessel   (Harris et al., 1996) presumptive embryonic/larval peripheral nervous system | restricted   (Harris et al., 1996) chordotonal organ   (Harris et al., 1996) embryonic/larval muscle system | restricted   (Harris et al., 1996) embryonic stage 12 -- 17   visceral mesoderm   (Harris et al., 1996) mesectoderm   (Harris et al., 1996) neuron of presumptive embryonic/larval nervous system   • axon (Harris et al., 1996) embryonic stage 13   stomatogastric nervous system   (Harris et al., 1996) midline glial cell   (Harris et al., 1996) embryonic stage 14   imaginal disc primordium   (Harris et al., 1996) eye-antennal disc primordium   (Harris et al., 1996) dorsal metathoracic disc primordium   (Harris et al., 1996) labial disc primordium   (Harris et al., 1996) genital disc primordium   (Harris et al., 1996) dorsal mesothoracic disc primordium   (Harris et al., 1996) embryonic stage 14 -- 17   central nervous system | restricted   (Harris et al., 1996) pupal stage P6 -- P7   lamina anlage | faint & restricted   (Timofeev et al., 2012) Comment:24-42h APF medulla anlage | dorsal & restricted   (Timofeev et al., 2012) Comment:24-42h APF neuron | subset of medulla | faint   (Timofeev et al., 2012) Comment:24-42h APF lobula   (Timofeev et al., 2012) Comment:24-42h APF pharate adult stage P8   lamina monopolar neuron L3   (Timofeev et al., 2012) Comment:55h APF medulla layer M3   (Timofeev et al., 2012) Comment:55h APF lobula   (Timofeev et al., 2012) Comment:55h APF neuron | subset of medulla   (Timofeev et al., 2012) Comment:55h APF adult stage   lamina monopolar neuron L3 | faint   (Timofeev et al., 2012) medulla layer M3 | faint   (Timofeev et al., 2012) lobula | faint   (Timofeev et al., 2012) neuron | subset of medulla | faint   (Timofeev et al., 2012)
Additional Descriptive Data
	NetB protein is expressed in the CNS starting in stage 12. It is first observed in cells just lateral to the midline and accumulates in midline cells by late stage 12. A variable degree of axon accumulation is observed starting in stage 12. At stage 14, a lateral group of neurons begins to express NetB. NetB expression is first observed in the developing mesoderm during germ band extension. Expression continues in a variety of mesoderm derivatives including the visceral mesoderm, the somatic mesoderm, and the dorsal vessel. Expressio is observed in the developing stomatogastric nervous system in stage 13. During stage 14, expression is apparent in imaginal disc primordia, including cells that will give rise to the eye-antennal, labial, wing, haltere, and genital discs. NetB protein accumulates in the developing PNS, including the chordotonal organs, and in muscles of both the dorsal and ventral groups. Earlier expression is seen in subsets of muscles. Later, expression is seen on motor axons as they synapse with these specific muscle groups. (Harris et al., 1996)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    782.8 Larval Midgut    14.2 Larval Hindgut    26.4 Larval Malpighian Tubules    53.8 Larval Fat Body    68.1 Larval Salivary Gland    8.1 Larval Trachea    43.2 Larval Carcass    46.7 Adult Head    149.2 Adult Eye    120.6 Adult Brain    628.3 Adult Thoracic-Abdominal Ganglion    588.1 Adult Crop    24.8 Adult Midgut    37.8 Adult Hindgut    49.4 Adult Malpighian Tubules    11.6 Adult Fat Body    29.8 Adult Salivary Gland    19.5 Adult Heart    59.025 Adult VirginFemale Spermatheca    39.1 Adult InseminatedFemale Spermatheca    50.5 Adult Ovary    9.9 Adult Testis    8.9 Adult Male Accessory Gland    17.6 Adult Carcass    32.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (782.8) Larval Midgut    14.2 Larval Hindgut    26.4 Larval Malpighian Tubules    53.8 Larval Fat Body    68.1 Larval Salivary Gland    8.1 Larval Trachea    43.2 Larval Carcass    46.7 Adult Head    149.2 Adult Eye    120.6 Adult Brain  (628.3) Adult Thoracic-Abdominal Ganglion  (588.1) Adult Crop    24.8 Adult Midgut    37.8 Adult Hindgut    49.4 Adult Malpighian Tubules    11.6 Adult Fat Body    29.8 Adult Salivary Gland    19.5 Adult Heart    59.025 Adult VirginFemale Spermatheca    39.1 Adult InseminatedFemale Spermatheca    50.5 Adult Ovary    9.9 Adult Testis    8.9 Adult Male Accessory Gland    17.6 Adult Carcass    32.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    782.8 Larval Midgut    14.2 Larval Hindgut    26.4 Larval Malpighian Tubules    53.8 Larval Fat Body    68.1 Larval Salivary Gland    8.1 Larval Trachea    43.2 Larval Carcass    46.7 Adult Head    149.2 Adult Eye    120.6 Adult Brain    628.3 Adult Thoracic-Abdominal Ganglion    588.1 Adult Crop    24.8 Adult Midgut    37.8 Adult Hindgut    49.4 Adult Malpighian Tubules    11.6 Adult Fat Body    29.8 Adult Salivary Gland    19.5 Adult Heart    59.025 Adult VirginFemale Spermatheca    39.1 Adult InseminatedFemale Spermatheca    50.5 Adult Ovary    9.9 Adult Testis    8.9 Adult Male Accessory Gland    17.6 Adult Carcass    32.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    782.8 Larval Midgut    14.2 Larval Hindgut    26.4 Larval Malpighian Tubules    53.8 Larval Fat Body    68.1 Larval Salivary Gland    8.1 Larval Trachea    43.2 Larval Carcass    46.7 Adult Head    149.2 Adult Eye    120.6 Adult Brain    628.3 Adult Thoracic-Abdominal Ganglion    588.1 Adult Crop    24.8 Adult Midgut    37.8 Adult Hindgut    49.4 Adult Malpighian Tubules    11.6 Adult Fat Body    29.8 Adult Salivary Gland    19.5 Adult Heart    59.025 Adult VirginFemale Spermatheca    39.1 Adult InseminatedFemale Spermatheca    50.5 Adult Ovary    9.9 Adult Testis    8.9 Adult Male Accessory Gland    17.6 Adult Carcass    32.9 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    782.8 Larval Midgut    14.2 Larval Hindgut    26.4 Larval Malpighian Tubules    53.8 Larval Fat Body    68.1 Larval Salivary Gland    8.1 Larval Trachea    43.2 Larval Carcass    46.7 Adult Head    149.2 Adult Eye    120.6 Adult Brain    628.3 Adult Thoracic-Abdominal Ganglion    588.1 Adult Crop    24.8 Adult Midgut    37.8 Adult Hindgut    49.4 Adult Malpighian Tubules    11.6 Adult Fat Body    29.8 Adult Salivary Gland    19.5 Adult Heart    59.025 Adult VirginFemale Spermatheca    39.1 Adult InseminatedFemale Spermatheca    50.5 Adult Ovary    9.9 Adult Testis    8.9 Adult Male Accessory Gland    17.6 Adult Carcass    32.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  782.8 Larval Midgut    14.2 Larval Hindgut    26.4 Larval Malpighian Tubules    53.8 Larval Fat Body    68.1 Larval Salivary Gland    8.1 Larval Trachea    43.2 Larval Carcass    46.7 Adult Head    149.2 Adult Eye    120.6 Adult Brain  628.3 Adult Thoracic-Abdominal Ganglion  588.1 Adult Crop    24.8 Adult Midgut    37.8 Adult Hindgut    49.4 Adult Malpighian Tubules    11.6 Adult Fat Body    29.8 Adult Salivary Gland    19.5 Adult Heart    59.025 Adult VirginFemale Spermatheca    39.1 Adult InseminatedFemale Spermatheca    50.5 Adult Ovary    9.9 Adult Testis    8.9 Adult Male Accessory Gland    17.6 Adult Carcass    32.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    782.8 Larval Midgut    14.2 Larval Hindgut    26.4 Larval Malpighian Tubules    53.8 Larval Fat Body    68.1 Larval Salivary Gland    8.1 Larval Trachea    43.2 Larval Carcass    46.7 Adult Head    149.2 Adult Eye    120.6 Adult Brain    628.3 Adult Thoracic-Abdominal Ganglion    588.1 Adult Crop    24.8 Adult Midgut    37.8 Adult Hindgut    49.4 Adult Malpighian Tubules    11.6 Adult Fat Body    29.8 Adult Salivary Gland    19.5 Adult Heart    59.025 Adult VirginFemale Spermatheca    39.1 Adult InseminatedFemale Spermatheca    50.5 Adult Ovary    9.9 Adult Testis    8.9 Adult Male Accessory Gland    17.6 Adult Carcass    32.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    782.8 Larval Midgut    14.2 Larval Hindgut    26.4 Larval Malpighian Tubules    53.8 Larval Fat Body    68.1 Larval Salivary Gland    8.1 Larval Trachea    43.2 Larval Carcass    46.7 Adult Head    149.2 Adult Eye    120.6 Adult Brain    628.3 Adult Thoracic-Abdominal Ganglion    588.1 Adult Crop    24.8 Adult Midgut    37.8 Adult Hindgut    49.4 Adult Malpighian Tubules    11.6 Adult Fat Body    29.8 Adult Salivary Gland    19.5 Adult Heart    59.025 Adult VirginFemale Spermatheca    39.1 Adult InseminatedFemale Spermatheca    50.5 Adult Ovary    9.9 Adult Testis    8.9 Adult Male Accessory Gland    17.6 Adult Carcass    32.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    149.2   NA  Eye    120.6   NA  Brain    628.3   782.8  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    588.1   NA  Crop    24.8   no informative data  Midgut    37.8   26.4  Hindgut    49.4   53.8  Malpighian Tubules    no informative data   68.1  Fat Body    29.8   8.1  Salivary Gland    no informative data   NA  Heart    59.025   43.2  Trachea    NA   NA  VirginFemale Spermatheca    39.1   NA  InseminatedFemale Spermatheca    50.5   NA  Ovary    9.9   NA  Testis    8.9   NA  Male Accessory Gland    no informative data   46.7  Carcass    32.9 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    19 central nervous system, pupae P8    44 head, virgin 1-day female    7 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    9 head, mated 20-day male    7 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    7 carcass, larvae L3 wandering    3 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    19 central nervous system, pupae P8  (44) head, virgin 1-day female    7 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    9 head, mated 20-day male    7 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    7 carcass, larvae L3 wandering    3 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    19 central nervous system, pupae P8    44 head, virgin 1-day female    7 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    9 head, mated 20-day male    7 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    7 carcass, larvae L3 wandering    3 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    19 central nervous system, pupae P8    44 head, virgin 1-day female    7 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    9 head, mated 20-day male    7 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    7 carcass, larvae L3 wandering    3 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    19 central nervous system, pupae P8    44 head, virgin 1-day female    7 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    9 head, mated 20-day male    7 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    7 carcass, larvae L3 wandering    3 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    19 central nervous system, pupae P8  (44) head, virgin 1-day female    7 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    9 head, mated 20-day male    7 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    7 carcass, larvae L3 wandering    3 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    19 central nervous system, pupae P8    44 head, virgin 1-day female    7 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    9 head, mated 20-day male    7 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    7 carcass, larvae L3 wandering    3 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    19 central nervous system, pupae P8    44 head, virgin 1-day female    7 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    9 head, mated 20-day male    7 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    7 carcass, larvae L3 wandering    3 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    9 embryo 06-08hr    10 embryo 08-10hr    13 embryo 10-12hr    10 embryo 12-14hr    14 embryo 14-16hr    12 embryo 16-18hr    14 embryo 18-20hr    12 embryo 20-22hr    7 embryo 22-24hr    10 larva L1    8 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    5 white prepupae new    6 white prepupae 12hr    8 white prepupae 24hr    14 pupae 2d postWPP    14 pupae 3d postWPP    6 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    3 adult male 30day    2 adult female 01day    1 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    9 embryo 06-08hr    10 embryo 08-10hr    13 embryo 10-12hr    10 embryo 12-14hr    14 embryo 14-16hr    12 embryo 16-18hr    14 embryo 18-20hr    12 embryo 20-22hr    7 embryo 22-24hr    10 larva L1    8 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    5 white prepupae new    6 white prepupae 12hr    8 white prepupae 24hr    14 pupae 2d postWPP    14 pupae 3d postWPP    6 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    3 adult male 30day    2 adult female 01day    1 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    9 embryo 06-08hr    10 embryo 08-10hr    13 embryo 10-12hr    10 embryo 12-14hr    14 embryo 14-16hr    12 embryo 16-18hr    14 embryo 18-20hr    12 embryo 20-22hr    7 embryo 22-24hr    10 larva L1    8 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    5 white prepupae new    6 white prepupae 12hr    8 white prepupae 24hr    14 pupae 2d postWPP    14 pupae 3d postWPP    6 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    3 adult male 30day    2 adult female 01day    1 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    9 embryo 06-08hr    10 embryo 08-10hr    13 embryo 10-12hr    10 embryo 12-14hr    14 embryo 14-16hr    12 embryo 16-18hr    14 embryo 18-20hr    12 embryo 20-22hr    7 embryo 22-24hr    10 larva L1    8 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    5 white prepupae new    6 white prepupae 12hr    8 white prepupae 24hr    14 pupae 2d postWPP    14 pupae 3d postWPP    6 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    3 adult male 30day    2 adult female 01day    1 adult female 05day    1 adult female 30day    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    9 embryo 06-08hr    10 embryo 08-10hr    13 embryo 10-12hr    10 embryo 12-14hr    14 embryo 14-16hr    12 embryo 16-18hr    14 embryo 18-20hr    12 embryo 20-22hr    7 embryo 22-24hr    10 larva L1    8 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    5 white prepupae new    6 white prepupae 12hr    8 white prepupae 24hr    14 pupae 2d postWPP    14 pupae 3d postWPP    6 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    3 adult male 30day    2 adult female 01day    1 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    9 embryo 06-08hr    10 embryo 08-10hr    13 embryo 10-12hr    10 embryo 12-14hr    14 embryo 14-16hr    12 embryo 16-18hr    14 embryo 18-20hr    12 embryo 20-22hr    7 embryo 22-24hr    10 larva L1    8 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    5 white prepupae new    6 white prepupae 12hr    8 white prepupae 24hr    14 pupae 2d postWPP    14 pupae 3d postWPP    6 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    3 adult male 30day    2 adult female 01day    1 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    9 embryo 06-08hr    10 embryo 08-10hr    13 embryo 10-12hr    10 embryo 12-14hr    14 embryo 14-16hr    12 embryo 16-18hr    14 embryo 18-20hr    12 embryo 20-22hr    7 embryo 22-24hr    10 larva L1    8 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    5 white prepupae new    6 white prepupae 12hr    8 white prepupae 24hr    14 pupae 2d postWPP    14 pupae 3d postWPP    6 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    3 adult male 30day    2 adult female 01day    1 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    9 embryo 06-08hr    10 embryo 08-10hr    13 embryo 10-12hr    10 embryo 12-14hr    14 embryo 14-16hr    12 embryo 16-18hr    14 embryo 18-20hr    12 embryo 20-22hr    7 embryo 22-24hr    10 larva L1    8 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    5 white prepupae new    6 white prepupae 12hr    8 white prepupae 24hr    14 pupae 2d postWPP    14 pupae 3d postWPP    6 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    3 adult male 30day    2 adult female 01day    1 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    23 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    2 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    23 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    2 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    23 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    2 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    23 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    2 ovary OSC    1 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    23 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    2 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    23 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    2 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    23 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    2 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    23 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    2 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_11 mE1_20_mRNA_expression_cluster_05
External Data & Images
Linkouts	BDGP expression data • GH10173 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015774 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10521-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for NetB Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele partially lethal - majority die, with Scer\GAL4c355 NetBGS1029 viable NetBBA00253 Other Phenotypes Allele neuroanatomy defective NetBGS1029 neuroanatomy defective, with Scer\GAL4how-24B NetBScer\UAS.T:Hsap\MYC neuroanatomy defective, with Scer\GAL4unspecified NetBScer\UAS.cHa neuroanatomy defective | embryonic stage NetBΔ neuroanatomy defective | third instar larval stage, with Scer\GAL4how-24B NetBGS1029 visible, with Scer\GAL429BD NetBGS1029 wild-type, with Scer\GAL4dpp.blk1 NetBGS1029 wild-type, with Scer\GAL4hs.2sev NetBGS1029 Phenotype manifest in Allele abdominal segmental nerve, with Scer\GAL4how-24B NetBScer\UAS.T:Hsap\MYC axon, with Scer\GAL4elav.PLu, Scer\GAL4sca-537.4 NetBScer\UAS.T:Hsap\MYC axon, with Scer\GAL4sca-537.4 NetBScer\UAS.cHa commissure, with Scer\GAL4elav.PLu, Scer\GAL4sca-537.4 NetBScer\UAS.T:Hsap\MYC commissure, with Scer\GAL4sca-537.4 NetBScer\UAS.cHa intersegmental nerve, with Scer\GAL4how-24B NetBScer\UAS.T:Hsap\MYC intersegmental nerve branch ISNb of A1-7 NetBGS1029 lamina, with Scer\GAL4Act5C.PP NetBScer\UAS.cHa longitudinal connective, with Scer\GAL4unspecified NetBScer\UAS.cHa motor neuron | third instar larval stage, with Scer\GAL4how-24B NetBGS1029 optic lobe NetBKI.T:SV5\V5,T:Zzzz\TM,T:Hsap\MYC optic lobe, with Df(1)NetABΔ, Scer\GAL4MH56 NetBScer\UAS.T:Hsap\MYC optic lobe, with Scer\GAL4ap-md544 NetBcd8.Scer\UAS optic lobe, with Scer\GAL4MH502 NetBcd8.Scer\UAS optic lobe | somatic clone, with Scer\GAL4GMR.long, Scer\GAL4Scer\FRT.Act5C NetBdsRNA.Scer\UAS optic nerve, with Scer\GAL4GMR.PF NetBScer\UAS.cHa pCC neuron & axon, with Scer\GAL4unspecified NetBScer\UAS.cHa peripheral glial cell | embryonic stage NetBΔ photoreceptor cell & axon, with Scer\GAL4Act5C.PP NetBScer\UAS.cHa photoreceptor cell & axon, with Scer\GAL4GMR.PF NetBScer\UAS.cHa photoreceptor cell R8 stalk NetBKI.T:SV5\V5,T:Zzzz\TM,T:Hsap\MYC photoreceptor cell R8 stalk, with Df(1)NetABΔ, Scer\GAL4MH56 NetBScer\UAS.T:Hsap\MYC photoreceptor cell R8 stalk, with Scer\GAL4ap-md544 NetBcd8.Scer\UAS photoreceptor cell R8 stalk, with Scer\GAL4MH502 NetBcd8.Scer\UAS photoreceptor cell R8 stalk | somatic clone, with Scer\GAL4GMR.long, Scer\GAL4Scer\FRT.Act5C NetBdsRNA.Scer\UAS presumptive embryonic salivary gland, with Scer\GAL4sca.PU NetBScer\UAS.T:Hsap\MYC presumptive embryonic salivary gland, with Scer\GAL4twi.PB NetBScer\UAS.T:Hsap\MYC segmental nerve, with Scer\GAL4A51 NetBScer\UAS.cHa segmental nerve, with Scer\GAL4how-24B NetBScer\UAS.cHa transverse nerve, with Scer\GAL4F63 NetBScer\UAS.cHa transverse nerve, with Scer\GAL4how-24B NetBScer\UAS.cHa wing, with Scer\GAL429BD NetBGS1029
Classical Alleles ( 23 )
For All Classical Alleles Show
Allele of NetB Class Mutagen Stocks Known lesion NetBc00047 1 -- NetBd00212 P-element activity 1 -- NetBd01008 P-element activity 1 -- NetBd03971 P-element activity 1 -- NetBe03288 piggyBac transposase 1 -- NetBEY20049 P-element activity 1 -- NetBf02394 piggyBac transposase 1 -- NetBf03698 piggyBac transposase 1 -- NetBf06092 piggyBac transposase 1 -- NetBKG01368 P-element activity 1 -- NetBKG03586 P-element activity 1 -- NetBNP0061 1 -- NetBNP0126 1 -- NetBNP0831 1 -- NetBNP1522 1 -- NetBBA00253 piggyBac transposase 0 Yes NetBCPTI000168 piggyBac transposase 0 Yes NetBCPTI000748 piggyBac transposase 0 Yes NetBGS1029 Delta2-3 0 Yes NetBKI.T:Hsap\MYC gene targeting by homologous recombination 0 Yes NetBKI.T:SV5\V5,T:Zzzz\TM,T:Hsap\MYC gene targeting by homologous recombination 0 Yes NetBunspecified 0 -- NetBΔ P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of NetB Class Mutagen Stocks Known lesion NetBHMS01177 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes NetBJF01882 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes NetBKK103672 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes NetBcd8.Scer\UAS in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes NetBdsRNA.Scer\UAS in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes NetBGD3356 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes NetBhs.sli.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes NetBScer\UAS.cHa in vitro construct - regulatory fusion 0 Yes NetBScer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)KA9 (Harris et al., 1996, Mitchell et al., 1996) Df(1)NP5 (Keleman and Dickson, 2001, Kolesnikov and Beckendorf, 2005, Mitchell et al., 1996, Mitchell, 1997.2.17, Sano et al., 2005, Al-Anzi and Wyman, 2009) Df(1)RK5 (Harris et al., 1996, Mitchell et al., 1996) Ts(1Lt;YSt)B118+Ts(1Rt;YLt)T9 (Winberg et al., 1998)
Not disrupted in	Df(1)RK4 (Mitchell et al., 1996) In(1)366.2 (Mitchell et al., 1996) In(1)P363 (Mitchell et al., 1996)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3356} NA P{KK103672} NA P{TRiP.HMS01177} NA P{TRiP.JF01882} NA P{UAS-NetB.cd8} NA P{UAS-NETB} NA P{UAS-NetrinB} NA heat-shock construct P{slit-NetB} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}NetBKG01368 NA P{SUPor-P}NetBKG03586 NA PBac{602.P.SVS-1}NetBCPTI000168 NA PBac{602.P.SVS-1}NetBCPTI000748 NA PBac{HpaI-GFP.A}NetBBA00253 NA PBac{PB}NetBc00047 NA PBac{RB}NetBe03288 NA PBac{WH}NetBf02394 NA PBac{WH}NetBf03698 NA PBac{WH}NetBf06092 NA insertion of enhancer trap binary system P{GawB}NetBNP0061 No P{GawB}NetBNP0126 No P{GawB}NetBNP0831 No P{GawB}NetBNP1522 No insertion of mobile activating element P{EPgy2}NetBEY20049 NA P{GSV1}NetBGS1029 NA P{XP}NetBd00212 NA P{XP}NetBd01008 NA P{XP}NetBd03971 NA
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
axon guidance inferred from genetic interaction with NetA (Brankatschk and Dickson, 2006) inferred from genetic interaction with unc-5 (Brankatschk and Dickson, 2006) dendrite guidance inferred from genetic interaction with NetA (Furrer et al., 2003) glial cell migration inferred from mutant phenotype (von Hilchen et al., 2010) motor neuron axon guidance inferred from mutant phenotype (Labrador et al., 2005) regulation of photoreceptor cell axon guidance inferred from mutant phenotype (Timofeev et al., 2012) salivary gland boundary specification inferred from mutant phenotype (Kolesnikov and Beckendorf, 2005) synaptic target recognition inferred from mutant phenotype (Kurusu et al., 2008)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
axon guidance inferred from sequence or structural similarity (Hynes and Zhao, 2000) non-traceable author statement (Swiss-Prot Project Members, 1997.2.1) synaptic target attraction traceable author statement (Chiba, 1999)
Cellular Component
CV term Evidence References
extracellular region inferred from sequence or structural similarity with worm unc-6 (Harris et al., 1996, Mitchell et al., 1996) proteinaceous extracellular matrix inferred from sequence or structural similarity (Hynes and Zhao, 2000)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions NetB allele Gene References NetBScer\UAS.cHa fra (Hiramoto et al., 2000) NetBScer\UAS.T:Hsap\MYC unc-5 (Keleman and Dickson, 2001) NetBunspecified NetA (Bhat, 2005) unspecified Nsf2 (Laviolette et al., 2005) unc-5 (Labrador et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58761 DroID - A comprehensive database of gene and protein interactions. • FBgn0015774 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32400
Orthologs
OrthoDB Orthologs (63) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG64QTKF Dipteran inclusive ortholog search EOG6NKC4K Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search EOG6S7H75 Metazoa inclusive ortholog search EOG628DTB
Orthologs in Drosophila Species (EOG64QTKF)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\NetB     Drosophila simulans   Dsim\NetB     Drosophila simulans   Dsim\GD15845     Drosophila sechellia   Dsec\GM12041     Drosophila erecta   Dere\GG19452     Drosophila yakuba   Dyak\GE16108     Drosophila ananassae   Dana\GF19299     Drosophila ananassae   Dana\GF21602 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA29267     Drosophila pseudoobscura pseudoobscura   Dpse\GA10368     Drosophila persimilis   Dper\GL20412     Drosophila persimilis   Dper\GL20414     Drosophila willistoni   Dwil\GK18468 Y   Drosophila virilis   Dvir\GJ18609 Y   Drosophila mojavensis   Dmoj\GI15750     Drosophila mojavensis   Dmoj\GI15749 Y   Drosophila grimshawi   Dgri\GH12218     Drosophila grimshawi   Dgri\GH12217
Orthologs in non-Drosophila Dipterans (EOG6NKC4K)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL003048   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ016787   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ016788   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ018929
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (EOG6S7H75)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Ixodes scapularis Deer tick  Isca\ISCW016330
Orthologs in non-Arthropod Metazoa (EOG628DTB)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\lam-2 Y Caenorhabditis elegans Nematode  Cele\unc-6 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_025057gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_006558gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_002896gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_004245gn Y Danio rerio Zebrafish  Drer\lamc1 Y Danio rerio Zebrafish  Drer\lamc3 Y Danio rerio Zebrafish  Drer\ENSDARG00000036422 Y Danio rerio Zebrafish  Drer\ntn1b Y Danio rerio Zebrafish  Drer\ntn1a Y Danio rerio Zebrafish  Drer\ntn2 Y Xenopus tropicalis Western clawed frog  Xtro\ntn1 Y Xenopus tropicalis Western clawed frog  Xtro\ntn1 Y Xenopus tropicalis Western clawed frog  Xtro\lamc2 Y Xenopus tropicalis Western clawed frog  Xtro\lamc1 Y Xenopus tropicalis Western clawed frog  Xtro\ntn3 Y Gallus gallus Domestic chicken  Ggal\LAMC1 Y Gallus gallus Domestic chicken  Ggal\LAMC3 Y Gallus gallus Domestic chicken  Ggal\LAMC2 Y Gallus gallus Domestic chicken  Ggal\NTN1 Y Gallus gallus Domestic chicken  Ggal\NTN1 Y Mus musculus House mouse  Mmus\Lamc1 Y Mus musculus House mouse  Mmus\Ntn3 Y Mus musculus House mouse  Mmus\Ntn5 Y Mus musculus House mouse  Mmus\Lamc2 Y Mus musculus House mouse  Mmus\Ntn1 Y Mus musculus House mouse  Mmus\Lamc3 Y Rattus norvegicus Norway rat  Rnor\Lamc2 Y Rattus norvegicus Norway rat  Rnor\Ntn5 Y Rattus norvegicus Norway rat  Rnor\Ntn1 Y Rattus norvegicus Norway rat  Rnor\Lamc1 Y Rattus norvegicus Norway rat  Rnor\Lamc3 Y Rattus norvegicus Norway rat  Rnor\Ntn3 Y Homo sapiens Human  Hsap\NTN3 Y Homo sapiens Human  Hsap\ENSG00000058085 Y Homo sapiens Human  Hsap\NTN5 Y Homo sapiens Human  Hsap\LAMC3 Y Homo sapiens Human  Hsap\NTN1 Y Homo sapiens Human  Hsap\LAMC1 Y
Human Orthologs (6)
Gene OMIM HGNC Hsap\NTN3     Hsap\ENSG00000058085     Hsap\NTN5     Hsap\LAMC3     Hsap\NTN1     Hsap\LAMC1
AAA Orthologs (4) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila ananassae Dana\GF21602 Drosophila willistoni Dwil\GK18468 Drosophila virilis Dvir\GJ18609 Drosophila mojavensis Dmoj\GI15749
Stocks & Reagents
Stocks Listed in FlyBase ( 18 )
Bloomington	13248 y1 P{SUPor-P}NetBKG03586
Harvard	- P{XP}NetBd00212 - P{XP}NetBd01008 - P{XP}NetBd03971 - PBac{PB}NetBc00047 - PBac{RB}NetBe03288 - PBac{WH}NetBf02394 - PBac{WH}NetBf03698 - PBac{WH}NetBf06092
Kyoto	112025 w* P{GawB}NetBNP0061 / FM7c 112053 w* P{GawB}NetBNP0126 / FM7c
VDRC	v100840 P{KK103672}VIE-260B
	More stocks available...
Genomic Clones ( 2 )
	BACR08K05 BACR22I24 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 108 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH10173
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LP04633 RE36994 RH04487 RH05258 RH05495 RH05858 RH07122 RH07567 RH15106 RH20926 RH21838 RH22186 RH24720 RH25094 RH25384 RH28406 RH30793 RH32577 RH37785 RH43647 RH45490
Other clones	12052 28436 28917 31531 32755 37823 63883 67176 71834 107390 145342 161841 214257.31 CK01.2D.B4 CK01.78D.G1 CK01.88B.D9 CK01.99B.B8 CK01.103B.F8 CK01.110D.F1 CK01.128C.B12 CK01037 EK061219 EK069613 EK070402 EK071704 EK073001 EK076540 EK083916 EK099738 EK101621 EK112846 EK136326 EK136959 EK143255 EK156013 EK164547 EK190819 EK195347 EK200352 EK244360 EK266090 EP21960 FGM301D04 LD14681 LP01627 RP004021774 RP004044264 RP004056676 RP004072319 RP004083009 RP004127327 RP004147246 RP004157684 RP004183293 RP004201643 RP004203159 RP004205864 RP004223386 RP004223512 RP004227639 RP004231351 RP004231856 RP004234009 RP004253014 RP004258032 RP004262493 RP004268143 RP004278470 RP004336275 RP004360439 RP004363513 RP004402258 RP004404437 RP004414305 RP004455139 RP004487072 RP004490073 RP004497079 RP004499546 RP004504804 RP004511243 RP004513275 RP004520767 RP004526515 RP004541851 RP004551396
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0015774 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32400
Antibody Information
	polyclonal (Harris et al., 1996, Albrecht et al., 2011)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	Layer specific localisation of NetA and NetB is sufficient for R8 targeting. (Timofeev et al., 2012) ChEST reveals this is a target of Mef2. (Junion et al., 2005) fra protein can capture Netrin protein (encoded by NetA and NetB) and "present" it for recognition by other receptors. (Hiramoto et al., 2000) Although the Netrins are expressed in the target of retinal axons, they are not required for retinal projections. (Gong et al., 1999) NetA and NetB function as short-range target recognition molecules for specific motoneurons. The relative balance of Sema-2a and the Netrins controls the choice of a specific target and the avoidance of a potential target. NetB and Sema-2a can both be repulsive for certain motor axons. fra is required for Netrin-mediated attraction, but not repulsion. (Winberg et al., 1998) NetA and NetB are expressed at the CNS midline and play an important role in commissural growth cone guidance. (Harris et al., 1996) Relationship to Netrin not known. (Mitchell et al., 1996) NetA and NetB are expressed by subsets of muscles and function in motor axon targetting. Ectopic expression and loss of function analysis in both the CNS and periphery demonstrates the pattern of netrin expression is crucial to correct patterning of axons, providing evidence that Netrins function as instructive rather than simply permissive, guidance cues. (Mitchell et al., 1996)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078600 NM_001169282 NM_001169283 NM_001169284 NM_001258739 NM_001258740 NM_001272617 RefSeq (Proteins) • NP_511155 NP_001162753 NP_001162754 NP_001162755 NP_001245668 NP_001245669 NP_001259546 DDBJ / EMBL / GenBank • AAB17534 AAB17548 AAF48382 AAL28219 ACZ95288 ACZ95289 ACZ95290 AFH07382 AFH07383 AGB95388 AI113735 AJ570661 AJ570662 AJ570663 AJ570664 AJ570665 AJ570666 AJ570668 AJ570669 AJ570670 AJ570671 AJ570672 AJ570673 AJ570674 AJ570675 AJ570676 AJ570677 AJ570679 AJ570680 AJ570681 AJ570682 AJ570683 AJ570684 AJ570685 AJ570686 AJ570688 AJ570690 AJ570691 AJ570692 AJ570693 AJ570694 AJ570695 AJ570696 AJ570697 AJ570698 AJ570699 AJ570701 AJ570702 AJ570703 AJ570704 AJ570705 AJ570706 AJ570707 AJ570708 AJ570709 AJ570710 AJ570712 AJ570713 AJ570714 AJ889663 AJ889664 AJ889665 AJ889666 AJ889667 AJ889668 AJ889669 AJ889670 AJ889671 AJ889672 AJ889673 AJ889674 AJ889675 AJ889676 AJ889677 AJ889678 AJ889679 AJ889680 AJ889681 AJ889682 AJ889683 AJ889684 AJ889685 AJ889686 AJ889687 AJ889688 AJ889689 AJ889690 AJ889691 AJ889692 AJ889693 AJ889694 AJ889695 AJ889696 AJ889697 AJ889698 AJ889699 AJ889700 AJ889701 AJ889702 AJ889703 AJ889704 AJ889705 AJ889706 AJ889707 AJ889708 AJ889709 AJ889710 AJ889711 AJ889712 AJ889713 AJ889714 AJ889715 AJ889716 AJ889717 AJ889718 AJ889719 AW940350 AY060671 BH614898 BH840428 CZ471456 CZ471457 CZ471968 CZ473660 CZ481058 CZ484904 CZ484905 CZ486277 CZ488736 CZ488737 U60317 U63737 Entrez Gene - A searchable database of RefSeq genes. • 32400 UniProtKB/Swiss-Prot • Q24568 UniProtKB/TrEMBL • E1JJP7 Q95SP5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Netrin module, non-TIMP type (IPR018933) Netrin domain (IPR001134) EGF-like, laminin (IPR002049) Laminin, N-terminal (IPR008211) Tissue inhibitor of metalloproteinases-like, OB-fold (IPR008993) Galactose-binding domain-like (IPR008979) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH10173
Linkouts
	BioGRID - A database of protein and genetic interactions • 58761 DroID - A comprehensive database of gene and protein interactions. • FBgn0015774 DRSC - Results from RNAi screens. • FBgn0015774 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015774 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10521-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0015774 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32400 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /newgene/netrins.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32400 modMine - Data generated by the modENCODE project. • FBgn0015774
Synonyms & Secondary IDs ( 16 )
Reported As
Symbol Synonym	CG10521 (Laviolette et al., 2005, Perkins et al., 1.15.2009, Keleman et al., 2009.8.5, Ni et al., 2010.12.1) CT29512 (Hynes and Zhao, 2000, Hynes and Zhao, 2000) net (Morikawa et al., 2011) netB (Kolesnikov and Beckendorf, 2005, Bhat, 2005, Bhat et al., 2007, Morikawa et al., 2011, Kurusu et al., 2008, Al-Anzi and Wyman, 2009, Manning et al., 2012) NetB (Laviolette et al., 2005, Kurusu et al., 2008, Buszczak et al., 2007, Brankatschk and Dickson, 2006, Hiramoto and Hiromi, 2006, Umemiya et al., 2002, Hazelett et al., 2012, Sano et al., 2005, Frise et al., 2010, Matthews and Grueber, 2011, Albrecht et al., 2011, Choksi et al., 2006, Andrews et al., 2008, Peng et al., 2007, Simanton et al., 2009, Spitzweck et al., 2010, Dorsten et al., 2010, von Hilchen et al., 2010, Mrkusich et al., 2010, Kuzina et al., 2011, Tan et al., 2012) NETB (Banyai and Patthy, 2004) netrin (Furrer et al., 2003) netrin B (Furrer et al., 2003)
Name Synonym	D-netrin-B (Mitchell et al., 1996) NETRIN (Kolesnikov and Beckendorf, 2005) netrin (Ackley and Jin, 2004, Dudu et al., 2004, O'Connor, 1999, Hughes and Salinas, 1999, Eisen, 1998, Arendt and Nubler-Jung, 1999, Hummel et al., 1999, Montell, 2006, Yang et al., 2009) Netrin (Kolesnikov and Beckendorf, 2004, Goegel et al., 2003, Keleman and Dickson, 2001, Giger and Kolodkin, 2001, Brose and Tessier-Lavigne, 2000, Sun et al., 2000, Onel et al., 1999, Seeger and Beattie, 1999, Schimmelpfeng et al., 1999, Murphey and Godenschwege, 2002, Morikawa et al., 2011, Banyai and Patthy, 2004, von Hilchen et al., 2010) Netrin B (Forsthoefel et al., 2003, Kuzin et al., 2005, Bousum et al., 2008, Hiramoto and Hiromi, 2006, Dorsten et al., 2010) netrinB (Hedgecock and Norris, 1997) Netrin-B (Mitchell, 1996.6.10, Harris, 1996.7.13, Noordermeer et al., 1998, Mitchell et al., 1996, Sano et al., 2005, Matthews and Grueber, 2011, Choksi et al., 2006, Garbe et al., 2007, Mrkusich et al., 2010, Timofeev et al., 2012, Tan et al., 2012) netrin B (Furrer et al., 2003, Umemiya et al., 2002) NetrinB (Liu et al., 2009, Brierley et al., 2009, Meyer et al., 2011) netrin-B (Enright et al., 2003, Manning et al., 2012)
Secondary FlyBase IDs
References ( 121 )
Generate a list of	All references relating to this gene ( 121 )
List References by type	Research paper  ( 53 ) Supplementary material  ( 4 ) Review  ( 30 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 13 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 2 ) Letter  ( 1 ) Protein sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 9 )
	Hazelett et al., 2012, G3 (Bethesda) 2(7): 789--802 Comparison of Parallel High-Throughput RNA Sequencing Between Knockout of TDP-43 and Its Overexpression Reveals Primarily Nonreciprocal and Nonoverlapping Gene Expression Changes in the Central Nervous System of Drosophila. [FBrf0219102] Manning et al., 2012, Cell Rep. 2(4): 1002--1013 A Resource for Manipulating Gene Expression and Analyzing cis-Regulatory Modules in the Drosophila CNS. [FBrf0219785] Tan et al., 2012, PLoS Genet. 8(5): e1002681 MicroRNA-277 Modulates the Neurodegeneration Caused by Fragile X Premutation rCGG Repeats. [FBrf0218227] Timofeev et al., 2012, Neuron 75(1): 80--93 Localized netrins act as positional cues to control layer-specific targeting of photoreceptor axons in Drosophila. [FBrf0218874] Albrecht et al., 2011, Dev. Biol. 350(1): 89--100 The transmembrane receptor Uncoordinated5 (Unc5) is essential for heart lumen formation in Drosophila melanogaster. [FBrf0212758] Kuzina et al., 2011, Development 138(9): 1839--1849 How Notch establishes longitudinal axon connections between successive segments of the Drosophila CNS. [FBrf0213493] Matthews and Grueber, 2011, Curr. Biol. 21(17): 1480--1487 Dscam1-mediated self-avoidance counters netrin-dependent targeting of dendrites in Drosophila. [FBrf0215596] Morikawa et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(48): 19389--19394 Different levels of the Tripartite motif protein, Anomalies in sensory axon patterning (Asap), regulate distinct axonal projections of Drosophila sensory neurons. [FBrf0216734] Pruteanu-Malinici et al., 2011, PLoS Comput. Biol. 7(7): e1002098 Automatic Annotation of Spatial Expression Patterns via Sparse Bayesian Factor Models. [FBrf0214618] Show all research papers ...
Recent reviews ( 1 )
	Meyer et al., 2011, Europ. J. Cell Biol. 90(9): 770--778 Drosophila metalloproteases in development and differentiation: The role of ADAM proteins and their relatives. [FBrf0214506] Show all reviews ...