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Gene Dmel\rin

General Information
Symbol	Dmel\rin	Species	D. melanogaster
Name	rasputin	Annotation symbol	CG9412
Feature type	protein_coding_gene	FlyBase ID	FBgn0015778
Gene Model Status	Current	Stock availability	16 publicly available
Also Known As	Nts, rasp
Genomic Location
Chromosome (arm)	3R	Recombination map	3-
Cytogenetic map	87F6-87F7	Sequence location	3R:9,472,726..9,478,135 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene rasputin is referred to in FlyBase by the symbol Dmel\rin (CG9412, FBgn0015778). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: mRNA binding; SH3 domain binding. There is experimental evidence that it is involved in the biological process: Ras protein signal transduction; compound eye photoreceptor fate commitment; ommatidial rotation. 20 alleles are reported. The phenotypes of these alleles are annotated with: eye disc; eye; eye photoreceptor cell; wing; ommatidial precursor cluster; ommatidium. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Nuclear transport factor 2; Nuclear transport factor 2, Eukaryote; Nucleotide-binding, alpha-beta plait; RNA recognition motif domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval trachea. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, adult female reproductive system, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1628937_s_at completely aligns to an exonic region common to each of the 5 FlyBase-annotated transcript isoforms of rin. Gene sequence location is 3R:9472726..9478135.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 87F6-87F7   Limits computationally determined from genome sequence between P{PZ}CtBP03463 and P{lacW}B52s2249&P{lacW}flflL4179
Experimentally Determined Cytological Location
Cytogenetic map Notes References 87F-87F     (Pazman, 2000.2.2) 87F3-87F6   (determined by in situ hybridisation)   (Pazman et al., 2000) 87F4-87F10     (Kelley, 1993)
Experimentally Determined Recombination Data
Location	3- (Kelley, 1993)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\rin for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46 Gene model reviewed during 5.47 Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated Annotated transcripts do not represent all supported alternative splices within 5' UTR. Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) rin-RB FBtr0082797  NM_080168   3268   690 rin-RE FBtr0082799  NM_169532   3501   690
Additional Transcript Data & Comments
Reported size (kB)	4.2, 3.7, 3.0 (northern blot) (Kelley, 1993) 3.314 (longest cDNA) (Pazman et al., 2000)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein rin-PB   FBpp0082265   74.9   690   7.41     NP_524907   AAG22151 rin-PE   FBpp0082267   74.9   690   7.41     NP_731829   AAN13573
Additional Polypeptide Data & Comments
Reported size (kDa)	690 (aa); 75 (kD observed) (Pazman et al., 2000)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Nuclear transport factor 2, Eukaryote (IPR018222) RNA recognition motif domain (IPR000504) Nuclear transport factor 2 (IPR002075) Nucleotide-binding, alpha-beta plait (IPR012677)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA440649   AA539986   AA696093   AA696134   AA696841   AA696969   AA696977   AA698454   AA801741   AA803040   AA803878   AA804117   AA949819   AA950771   AA950992   AA951760   AA952210   AA979348   AE014297 AAG22151   AE014297 AAN13573   AF231031 AAF68949   AI062924   AI108458   AI108801   AI257081   AI257559   AI257640   AI259127   AI259637   AI259688   AI259721   AI260192   AI260425   AI292733   AI294879   AI294970   AI295349   AI403020   AI405635   AI456239   AI515315   AI534719   AI541700   AI542232   AI945356   AI946629   AI947179   AW943068   AY058617 AAL13846   BF486860   BF487380   BF487455   BF487695   BF488253   BF488541   BF488928   BF489043   BF489245   BF490942   BF490987   BF491103   BF491748   BF491761   BF491866   BF493767   BF493869   BF494848   BF494967   BF496846   BF497416   BF498660   BF499032   BF499245   BF499301   BF499817   BF500495   BF500734   BF500743   BF501745   BF502330   BF502581   BF502645   BF503524   BF504173   BF504185   BF504476   BF504764   BF504816   BF505154   BF505604   BF506661   BG633682   BG633772   BG634630   BG634738   BG634983   BG635545   BG636210   BG636679   BG637558   BI162352   BI163659   BI164674   BI165028   BI167299   BI168286   BI169097   BI169451   BI171932   BI212904   BI213866   BI216433   BI216540   BI216613   BI229128   BI229267   BI230233   BI230319   BI230721   BI231191   BI231893   BI232081   BI232170   BI232488   BI232499   BI236794   BI236962   BI237773   BI237947   BI242451   BI243375   BI354372   BI354374   BI356755   BI356867   BI357555   BI357579   BI362109   BI364377   BI365963   BI366609   BI368970   BI371998   BI372066   BI485788   BI487071   BI569727   BI573313   BI578814   BI579103   BI579104   BI580742   BI593479   BI636454   BI636658   BI639310   BI640960   BP541234   BP541235   BP549976   BP549977   BP554731   BP554732   BP555207   BP555208   BQ103279   BT011006   CK657257   CK658290   CK658831   CK659665   CK661143   CK661936   CL705802   CO152737   CO262475   CO265519   CO267650   CO274825   CO274849   CO287061   CO287625   CO288071   CO289049   CO291125   CO325193   CO328376   CO330496   CO330904   CO335514   CO336251   CO336311   CO337318   CO337434   CO338901   CO339244   CZ466368   CZ467879   CZ486695   CZ487626   CZ487627   DU708604   EC052625   EC061220   EC070043   EC070476   EC072853   EC074140   EC081524   EC197004   EC198207   EC199225   EC208034   EC216355   EC219798   EC224231   EC228918   EC241969   EC242108   EC242385   EC249018   EC250782   EC256705   EC258316   EC259958   EC260789   EC263379   EC264087   EC266859   EC267777   EC267907   ES693063   EV588624   EV588748   EV589716   EV591089   EV595364   GH750986   GH752786   GH753111   GH754119   GH754694   GH755785   GH756617   GH757070   GH757395   GH760003   GH773411   GH773904   GH775782   GH776720   GH777384   GH777631   GH777673   GH778308   GH779112   GH782013   GH783437   GH783607   GH783655   GH789004   GH793776   GH794670   GH796525   GH797817   GH808537   GH809275   GH811302   GH812167   GH812914   GH814060   GH814836   GH816437   GH817008   GH817635   GH818320   GH821508   GH821964   GH822267   GH824983   GH827120   GH827821   GH830161   GH834258   GH837295   GH840788   GH849819   GH850352   GH850547   GH850958   GH853033   GH856517   GH856580   GH856853   GH857924   GH858955   GH859440   GH859852   GH860865   GH861134   GH862300   GH862879   GH865141   GH865305   GH870915   GH871734   GH873940   GH874948   GH876021   GH881502   GH882291   GH883403   GH884492   GH885758   GH886042   GH889076   GH889486   GH889659   GH892917   GH894555   GH897238   GH897728   GH898157   GH899773   GH901097   GH903629   GH905532   GH909798   GH911277   GH911622   GH912295   GH912599   GH915090   GH915553   GH915875   GH915939   GH920814   GH920920   GH921113   GH921335   GH921498   GH924045   GH924049   GH925764   GH926792   GH928138   GH928786   GH929224   GH930186   GH930508   GH934999   GH935430
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VFT4 Q9NH72
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | ubiquitous   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- pupal stage     (Pazman et al., 2000) adult stage | female     (Pazman et al., 2000)
Additional Descriptive Data
	rin transcripts are detected in embryos, larvae, early and late pupae, and adult females, with highest levels of transcripts in 0-3 hr embryos. (Pazman et al., 2000)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Pazman et al., 2000) third instar larval stage   eye disc   (Pazman et al., 2000) photoreceptor cell | precursor   (Pazman et al., 2000)
Additional Descriptive Data
	rin protein is detected throughout development. In developing eye imaginal discs, rin protein is localized apically in photoreceptor precursor cells, in a pattern similar to that of other Ras pathway proteins Sos, dos and drk. (Pazman et al., 2000)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
catalytic step 2 spliceosome inferred from direct assay (Herold et al., 2009) cytosol inferred from direct assay (Pazman et al., 2000) lipid particle inferred from direct assay (Cermelli et al., 2006) precatalytic spliceosome inferred from direct assay (Herold et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval trachea. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, adult female reproductive system, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    528.275 Larval Midgut    120.5 Larval Hindgut    220.2 Larval Malpighian Tubules    189.3 Larval Fat Body    132.5 Larval Salivary Gland    267.2 Larval Trachea    629.225 Larval Carcass    265.775 Adult Head    98.1 Adult Eye    293.05 Adult Brain    187.5 Adult Thoracic-Abdominal Ganglion    137.6 Adult Crop    150 Adult Midgut    113.8 Adult Hindgut    133.8 Adult Malpighian Tubules    70.5 Adult Fat Body    153.5 Adult Salivary Gland    131.1 Adult Heart    321.6 Adult VirginFemale Spermatheca    123.7 Adult InseminatedFemale Spermatheca    118.9 Adult Ovary    441.4 Adult Testis    98.3 Adult Male Accessory Gland    169.4 Adult Carcass    84 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  528.275 Larval Midgut    120.5 Larval Hindgut    220.2 Larval Malpighian Tubules    189.3 Larval Fat Body    132.5 Larval Salivary Gland    267.2 Larval Trachea  (629.225) Larval Carcass    265.775 Adult Head    98.1 Adult Eye    293.05 Adult Brain    187.5 Adult Thoracic-Abdominal Ganglion    137.6 Adult Crop    150 Adult Midgut    113.8 Adult Hindgut    133.8 Adult Malpighian Tubules    70.5 Adult Fat Body    153.5 Adult Salivary Gland    131.1 Adult Heart    321.6 Adult VirginFemale Spermatheca    123.7 Adult InseminatedFemale Spermatheca    118.9 Adult Ovary    441.4 Adult Testis    98.3 Adult Male Accessory Gland    169.4 Adult Carcass    84 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    528.275 Larval Midgut    120.5 Larval Hindgut    220.2 Larval Malpighian Tubules    189.3 Larval Fat Body    132.5 Larval Salivary Gland    267.2 Larval Trachea    629.225 Larval Carcass    265.775 Adult Head    98.1 Adult Eye    293.05 Adult Brain    187.5 Adult Thoracic-Abdominal Ganglion    137.6 Adult Crop    150 Adult Midgut    113.8 Adult Hindgut    133.8 Adult Malpighian Tubules    70.5 Adult Fat Body    153.5 Adult Salivary Gland    131.1 Adult Heart    321.6 Adult VirginFemale Spermatheca    123.7 Adult InseminatedFemale Spermatheca    118.9 Adult Ovary    441.4 Adult Testis    98.3 Adult Male Accessory Gland    169.4 Adult Carcass    84 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    528.275 Larval Midgut    120.5 Larval Hindgut    220.2 Larval Malpighian Tubules    189.3 Larval Fat Body    132.5 Larval Salivary Gland    267.2 Larval Trachea    629.225 Larval Carcass    265.775 Adult Head    98.1 Adult Eye    293.05 Adult Brain    187.5 Adult Thoracic-Abdominal Ganglion    137.6 Adult Crop    150 Adult Midgut    113.8 Adult Hindgut    133.8 Adult Malpighian Tubules    70.5 Adult Fat Body    153.5 Adult Salivary Gland    131.1 Adult Heart    321.6 Adult VirginFemale Spermatheca    123.7 Adult InseminatedFemale Spermatheca    118.9 Adult Ovary    441.4 Adult Testis    98.3 Adult Male Accessory Gland    169.4 Adult Carcass    84 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    528.275 Larval Midgut    120.5 Larval Hindgut    220.2 Larval Malpighian Tubules    189.3 Larval Fat Body    132.5 Larval Salivary Gland    267.2 Larval Trachea    629.225 Larval Carcass    265.775 Adult Head    98.1 Adult Eye    293.05 Adult Brain    187.5 Adult Thoracic-Abdominal Ganglion    137.6 Adult Crop    150 Adult Midgut    113.8 Adult Hindgut    133.8 Adult Malpighian Tubules    70.5 Adult Fat Body    153.5 Adult Salivary Gland    131.1 Adult Heart    321.6 Adult VirginFemale Spermatheca    123.7 Adult InseminatedFemale Spermatheca    118.9 Adult Ovary    441.4 Adult Testis    98.3 Adult Male Accessory Gland    169.4 Adult Carcass    84 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  528.275 Larval Midgut    120.5 Larval Hindgut    220.2 Larval Malpighian Tubules    189.3 Larval Fat Body    132.5 Larval Salivary Gland    267.2 Larval Trachea  629.225 Larval Carcass    265.775 Adult Head    98.1 Adult Eye    293.05 Adult Brain    187.5 Adult Thoracic-Abdominal Ganglion    137.6 Adult Crop    150 Adult Midgut    113.8 Adult Hindgut    133.8 Adult Malpighian Tubules    70.5 Adult Fat Body    153.5 Adult Salivary Gland    131.1 Adult Heart    321.6 Adult VirginFemale Spermatheca    123.7 Adult InseminatedFemale Spermatheca    118.9 Adult Ovary    441.4 Adult Testis    98.3 Adult Male Accessory Gland    169.4 Adult Carcass    84 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    528.275 Larval Midgut    120.5 Larval Hindgut    220.2 Larval Malpighian Tubules    189.3 Larval Fat Body    132.5 Larval Salivary Gland    267.2 Larval Trachea    629.225 Larval Carcass    265.775 Adult Head    98.1 Adult Eye    293.05 Adult Brain    187.5 Adult Thoracic-Abdominal Ganglion    137.6 Adult Crop    150 Adult Midgut    113.8 Adult Hindgut    133.8 Adult Malpighian Tubules    70.5 Adult Fat Body    153.5 Adult Salivary Gland    131.1 Adult Heart    321.6 Adult VirginFemale Spermatheca    123.7 Adult InseminatedFemale Spermatheca    118.9 Adult Ovary    441.4 Adult Testis    98.3 Adult Male Accessory Gland    169.4 Adult Carcass    84 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    528.275 Larval Midgut    120.5 Larval Hindgut    220.2 Larval Malpighian Tubules    189.3 Larval Fat Body    132.5 Larval Salivary Gland    267.2 Larval Trachea    629.225 Larval Carcass    265.775 Adult Head    98.1 Adult Eye    293.05 Adult Brain    187.5 Adult Thoracic-Abdominal Ganglion    137.6 Adult Crop    150 Adult Midgut    113.8 Adult Hindgut    133.8 Adult Malpighian Tubules    70.5 Adult Fat Body    153.5 Adult Salivary Gland    131.1 Adult Heart    321.6 Adult VirginFemale Spermatheca    123.7 Adult InseminatedFemale Spermatheca    118.9 Adult Ovary    441.4 Adult Testis    98.3 Adult Male Accessory Gland    169.4 Adult Carcass    84 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    98.1   NA  Eye    293.05   NA  Brain    187.5   528.275  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    137.6   NA  Crop    150   120.5  Midgut    113.8   220.2  Hindgut    133.8   189.3  Malpighian Tubules    70.5   132.5  Fat Body    153.5   267.2  Salivary Gland    131.1   NA  Heart    321.6   629.225  Trachea    NA   NA  VirginFemale Spermatheca    123.7   NA  InseminatedFemale Spermatheca    118.9   NA  Ovary    441.4   NA  Testis    98.3   NA  Male Accessory Gland    169.4   265.775  Carcass    84 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    310 central nervous system, larvae L3    391 central nervous system, pupae P8    188 head, virgin 1-day female    56 head, virgin 4-day female    51 head, virgin 20-day female    28 head, mated 1-day female    53 head, mated 4-day female    62 head, mated 20-day female    35 head, mated 1-day male    58 head, mated 4-day male    90 head, mated 20-day male    83 salivary gland, larvae L3 wandering    12 salivary gland, white prepupae    68 digestive system, larvae L3 wandering    69 digestive system, 1-day adult    48 digestive system, 4-day adult    86 digestive system, 20-day adult    69 fat body, larvae L3 wandering    50 fat body, white prepupae    112 fat body, pupae P8    73 carcass, larvae L3 wandering    208 carcass, 1-day adult    57 carcass, 4-day adult    78 carcass, 20-day adult    58 ovary, virgin 4-day female    488 ovary, mated 4-day female    552 testis, mated 4-day male    162 accessory gland, mated 4-day male    56 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (310) central nervous system, larvae L3  (391) central nervous system, pupae P8  (188) head, virgin 1-day female  (56) head, virgin 4-day female  (51) head, virgin 20-day female  (28) head, mated 1-day female  (53) head, mated 4-day female  (62) head, mated 20-day female  (35) head, mated 1-day male  (58) head, mated 4-day male  (90) head, mated 20-day male  (83) salivary gland, larvae L3 wandering    12 salivary gland, white prepupae  (68) digestive system, larvae L3 wandering  (69) digestive system, 1-day adult  (48) digestive system, 4-day adult  (86) digestive system, 20-day adult  (69) fat body, larvae L3 wandering  (50) fat body, white prepupae  (112) fat body, pupae P8  (73) carcass, larvae L3 wandering  (208) carcass, 1-day adult  (57) carcass, 4-day adult  (78) carcass, 20-day adult  (58) ovary, virgin 4-day female  (488) ovary, mated 4-day female  (552) testis, mated 4-day male  (162) accessory gland, mated 4-day male  (56) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (310) central nervous system, larvae L3  (391) central nervous system, pupae P8  (188) head, virgin 1-day female    56 head, virgin 4-day female    51 head, virgin 20-day female    28 head, mated 1-day female    53 head, mated 4-day female    62 head, mated 20-day female    35 head, mated 1-day male    58 head, mated 4-day male    90 head, mated 20-day male    83 salivary gland, larvae L3 wandering    12 salivary gland, white prepupae    68 digestive system, larvae L3 wandering    69 digestive system, 1-day adult    48 digestive system, 4-day adult    86 digestive system, 20-day adult    69 fat body, larvae L3 wandering    50 fat body, white prepupae  (112) fat body, pupae P8    73 carcass, larvae L3 wandering  (208) carcass, 1-day adult    57 carcass, 4-day adult    78 carcass, 20-day adult    58 ovary, virgin 4-day female  (488) ovary, mated 4-day female  (552) testis, mated 4-day male  (162) accessory gland, mated 4-day male    56 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    310 central nervous system, larvae L3    391 central nervous system, pupae P8    188 head, virgin 1-day female    56 head, virgin 4-day female    51 head, virgin 20-day female    28 head, mated 1-day female    53 head, mated 4-day female    62 head, mated 20-day female    35 head, mated 1-day male    58 head, mated 4-day male    90 head, mated 20-day male    83 salivary gland, larvae L3 wandering    12 salivary gland, white prepupae    68 digestive system, larvae L3 wandering    69 digestive system, 1-day adult    48 digestive system, 4-day adult    86 digestive system, 20-day adult    69 fat body, larvae L3 wandering    50 fat body, white prepupae    112 fat body, pupae P8    73 carcass, larvae L3 wandering    208 carcass, 1-day adult    57 carcass, 4-day adult    78 carcass, 20-day adult    58 ovary, virgin 4-day female    488 ovary, mated 4-day female    552 testis, mated 4-day male    162 accessory gland, mated 4-day male    56 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    310 central nervous system, larvae L3    391 central nervous system, pupae P8    188 head, virgin 1-day female    56 head, virgin 4-day female    51 head, virgin 20-day female    28 head, mated 1-day female    53 head, mated 4-day female    62 head, mated 20-day female    35 head, mated 1-day male    58 head, mated 4-day male    90 head, mated 20-day male    83 salivary gland, larvae L3 wandering    12 salivary gland, white prepupae    68 digestive system, larvae L3 wandering    69 digestive system, 1-day adult    48 digestive system, 4-day adult    86 digestive system, 20-day adult    69 fat body, larvae L3 wandering    50 fat body, white prepupae    112 fat body, pupae P8    73 carcass, larvae L3 wandering    208 carcass, 1-day adult    57 carcass, 4-day adult    78 carcass, 20-day adult    58 ovary, virgin 4-day female    488 ovary, mated 4-day female    552 testis, mated 4-day male    162 accessory gland, mated 4-day male    56 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (310) central nervous system, larvae L3  (391) central nervous system, pupae P8  (188) head, virgin 1-day female  (56) head, virgin 4-day female  (51) head, virgin 20-day female  28 head, mated 1-day female  (53) head, mated 4-day female  (62) head, mated 20-day female  (35) head, mated 1-day male  (58) head, mated 4-day male  (90) head, mated 20-day male  (83) salivary gland, larvae L3 wandering    12 salivary gland, white prepupae  (68) digestive system, larvae L3 wandering  (69) digestive system, 1-day adult  (48) digestive system, 4-day adult  (86) digestive system, 20-day adult  (69) fat body, larvae L3 wandering  (50) fat body, white prepupae  (112) fat body, pupae P8  (73) carcass, larvae L3 wandering  (208) carcass, 1-day adult  (57) carcass, 4-day adult  (78) carcass, 20-day adult  (58) ovary, virgin 4-day female  (488) ovary, mated 4-day female  (552) testis, mated 4-day male  (162) accessory gland, mated 4-day male  (56) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (310) central nervous system, larvae L3  (391) central nervous system, pupae P8  (188) head, virgin 1-day female    56 head, virgin 4-day female    51 head, virgin 20-day female    28 head, mated 1-day female    53 head, mated 4-day female    62 head, mated 20-day female    35 head, mated 1-day male    58 head, mated 4-day male    90 head, mated 20-day male    83 salivary gland, larvae L3 wandering    12 salivary gland, white prepupae    68 digestive system, larvae L3 wandering    69 digestive system, 1-day adult    48 digestive system, 4-day adult    86 digestive system, 20-day adult    69 fat body, larvae L3 wandering    50 fat body, white prepupae  112 fat body, pupae P8    73 carcass, larvae L3 wandering  (208) carcass, 1-day adult    57 carcass, 4-day adult    78 carcass, 20-day adult    58 ovary, virgin 4-day female  (488) ovary, mated 4-day female  (552) testis, mated 4-day male  (162) accessory gland, mated 4-day male    56 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    310 central nervous system, larvae L3    391 central nervous system, pupae P8    188 head, virgin 1-day female    56 head, virgin 4-day female    51 head, virgin 20-day female    28 head, mated 1-day female    53 head, mated 4-day female    62 head, mated 20-day female    35 head, mated 1-day male    58 head, mated 4-day male    90 head, mated 20-day male    83 salivary gland, larvae L3 wandering    12 salivary gland, white prepupae    68 digestive system, larvae L3 wandering    69 digestive system, 1-day adult    48 digestive system, 4-day adult    86 digestive system, 20-day adult    69 fat body, larvae L3 wandering    50 fat body, white prepupae    112 fat body, pupae P8    73 carcass, larvae L3 wandering    208 carcass, 1-day adult    57 carcass, 4-day adult    78 carcass, 20-day adult    58 ovary, virgin 4-day female    488 ovary, mated 4-day female    552 testis, mated 4-day male    162 accessory gland, mated 4-day male    56 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    215 embryo 02-04hr    138 embryo 04-06hr    97 embryo 06-08hr    118 embryo 08-10hr    106 embryo 10-12hr    91 embryo 12-14hr    74 embryo 14-16hr    53 embryo 16-18hr    30 embryo 18-20hr    21 embryo 20-22hr    18 embryo 22-24hr    14 larva L1    67 larva L2    58 larva L3 12hr old    53 larva L3 puffstage 1-2    37 larva L3 puffstage 3-6    95 larva L3 puffstage 7-9    95 white prepupae new    100 white prepupae 12hr    108 white prepupae 24hr    132 pupae 2d postWPP    88 pupae 3d postWPP    72 pupae 4d postWPP    60 adult male 01day    70 adult male 05day    96 adult male 30day    99 adult female 01day    127 adult female 05day    176 adult female 30day    164 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (215) embryo 02-04hr  (138) embryo 04-06hr  (97) embryo 06-08hr  (118) embryo 08-10hr  (106) embryo 10-12hr  (91) embryo 12-14hr  (74) embryo 14-16hr  (53) embryo 16-18hr  (30) embryo 18-20hr    21 embryo 20-22hr    18 embryo 22-24hr    14 larva L1  (67) larva L2  (58) larva L3 12hr old  (53) larva L3 puffstage 1-2  (37) larva L3 puffstage 3-6  (95) larva L3 puffstage 7-9  (95) white prepupae new  (100) white prepupae 12hr  (108) white prepupae 24hr  (132) pupae 2d postWPP  (88) pupae 3d postWPP  (72) pupae 4d postWPP  (60) adult male 01day  (70) adult male 05day  (96) adult male 30day  (99) adult female 01day  (127) adult female 05day  (176) adult female 30day  (164) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (215) embryo 02-04hr  (138) embryo 04-06hr    97 embryo 06-08hr  (118) embryo 08-10hr  106 embryo 10-12hr    91 embryo 12-14hr    74 embryo 14-16hr    53 embryo 16-18hr    30 embryo 18-20hr    21 embryo 20-22hr    18 embryo 22-24hr    14 larva L1    67 larva L2    58 larva L3 12hr old    53 larva L3 puffstage 1-2    37 larva L3 puffstage 3-6    95 larva L3 puffstage 7-9    95 white prepupae new    100 white prepupae 12hr  (108) white prepupae 24hr  (132) pupae 2d postWPP    88 pupae 3d postWPP    72 pupae 4d postWPP    60 adult male 01day    70 adult male 05day    96 adult male 30day    99 adult female 01day  (127) adult female 05day  (176) adult female 30day  (164) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    215 embryo 02-04hr    138 embryo 04-06hr    97 embryo 06-08hr    118 embryo 08-10hr    106 embryo 10-12hr    91 embryo 12-14hr    74 embryo 14-16hr    53 embryo 16-18hr    30 embryo 18-20hr    21 embryo 20-22hr    18 embryo 22-24hr    14 larva L1    67 larva L2    58 larva L3 12hr old    53 larva L3 puffstage 1-2    37 larva L3 puffstage 3-6    95 larva L3 puffstage 7-9    95 white prepupae new    100 white prepupae 12hr    108 white prepupae 24hr    132 pupae 2d postWPP    88 pupae 3d postWPP    72 pupae 4d postWPP    60 adult male 01day    70 adult male 05day    96 adult male 30day    99 adult female 01day    127 adult female 05day    176 adult female 30day    164 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    215 embryo 02-04hr    138 embryo 04-06hr    97 embryo 06-08hr    118 embryo 08-10hr    106 embryo 10-12hr    91 embryo 12-14hr    74 embryo 14-16hr    53 embryo 16-18hr    30 embryo 18-20hr    21 embryo 20-22hr    18 embryo 22-24hr    14 larva L1    67 larva L2    58 larva L3 12hr old    53 larva L3 puffstage 1-2    37 larva L3 puffstage 3-6    95 larva L3 puffstage 7-9    95 white prepupae new    100 white prepupae 12hr    108 white prepupae 24hr    132 pupae 2d postWPP    88 pupae 3d postWPP    72 pupae 4d postWPP    60 adult male 01day    70 adult male 05day    96 adult male 30day    99 adult female 01day    127 adult female 05day    176 adult female 30day    164 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (215) embryo 02-04hr  (138) embryo 04-06hr  (97) embryo 06-08hr  (118) embryo 08-10hr  (106) embryo 10-12hr  (91) embryo 12-14hr  (74) embryo 14-16hr  (53) embryo 16-18hr  30 embryo 18-20hr    21 embryo 20-22hr    18 embryo 22-24hr    14 larva L1  (67) larva L2  (58) larva L3 12hr old  (53) larva L3 puffstage 1-2  (37) larva L3 puffstage 3-6  (95) larva L3 puffstage 7-9  (95) white prepupae new  (100) white prepupae 12hr  (108) white prepupae 24hr  (132) pupae 2d postWPP  (88) pupae 3d postWPP  (72) pupae 4d postWPP  (60) adult male 01day  (70) adult male 05day  (96) adult male 30day  (99) adult female 01day  (127) adult female 05day  (176) adult female 30day  (164) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (215) embryo 02-04hr  138 embryo 04-06hr    97 embryo 06-08hr  118 embryo 08-10hr  106 embryo 10-12hr    91 embryo 12-14hr    74 embryo 14-16hr    53 embryo 16-18hr    30 embryo 18-20hr    21 embryo 20-22hr    18 embryo 22-24hr    14 larva L1    67 larva L2    58 larva L3 12hr old    53 larva L3 puffstage 1-2    37 larva L3 puffstage 3-6    95 larva L3 puffstage 7-9    95 white prepupae new    100 white prepupae 12hr  108 white prepupae 24hr  132 pupae 2d postWPP    88 pupae 3d postWPP    72 pupae 4d postWPP    60 adult male 01day    70 adult male 05day    96 adult male 30day    99 adult female 01day  127 adult female 05day  (176) adult female 30day  (164) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    215 embryo 02-04hr    138 embryo 04-06hr    97 embryo 06-08hr    118 embryo 08-10hr    106 embryo 10-12hr    91 embryo 12-14hr    74 embryo 14-16hr    53 embryo 16-18hr    30 embryo 18-20hr    21 embryo 20-22hr    18 embryo 22-24hr    14 larva L1    67 larva L2    58 larva L3 12hr old    53 larva L3 puffstage 1-2    37 larva L3 puffstage 3-6    95 larva L3 puffstage 7-9    95 white prepupae new    100 white prepupae 12hr    108 white prepupae 24hr    132 pupae 2d postWPP    88 pupae 3d postWPP    72 pupae 4d postWPP    60 adult male 01day    70 adult male 05day    96 adult male 30day    99 adult female 01day    127 adult female 05day    176 adult female 30day    164 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    328 Schneider line 2 Sg4    200 embryonic 1182-4H    337 embryonic GM2    327 embryonic Kc167    356 embryonic S1    418 embryonic S3    315 leg disc CME L1    231 wing disc CME-W2    248 wing disc ML-DmD8    307 wing disc ML-DmD9    319 wing disc ML-DmD16-c3    282 wing disc ML-DmD21    269 wing disc ML-DmD32    348 haltere disc ML-DmD17-c3    325 eye-antennal disc ML-DmD11    237 antennal disc ML-DmD20-c5    180 mixed discs ML-DmD4-c1    212 CNS ML-DmBG1-c1    219 CNS ML-DmBG2-c2    169 tumorous blood cells mbn2    140 ovary fGS/OSS    583 ovary OSC    826 ovary OSS    417 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (328) Schneider line 2 Sg4  (200) embryonic 1182-4H  (337) embryonic GM2  (327) embryonic Kc167  (356) embryonic S1  (418) embryonic S3  (315) leg disc CME L1  (231) wing disc CME-W2  (248) wing disc ML-DmD8  (307) wing disc ML-DmD9  (319) wing disc ML-DmD16-c3  (282) wing disc ML-DmD21  (269) wing disc ML-DmD32  (348) haltere disc ML-DmD17-c3  (325) eye-antennal disc ML-DmD11  (237) antennal disc ML-DmD20-c5  (180) mixed discs ML-DmD4-c1  (212) CNS ML-DmBG1-c1  (219) CNS ML-DmBG2-c2  (169) tumorous blood cells mbn2  (140) ovary fGS/OSS  (583) ovary OSC  (826) ovary OSS  (417) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (328) Schneider line 2 Sg4  (200) embryonic 1182-4H  (337) embryonic GM2  (327) embryonic Kc167  (356) embryonic S1  (418) embryonic S3  (315) leg disc CME L1  (231) wing disc CME-W2  (248) wing disc ML-DmD8  (307) wing disc ML-DmD9  (319) wing disc ML-DmD16-c3  (282) wing disc ML-DmD21  (269) wing disc ML-DmD32  (348) haltere disc ML-DmD17-c3  (325) eye-antennal disc ML-DmD11  (237) antennal disc ML-DmD20-c5  (180) mixed discs ML-DmD4-c1  (212) CNS ML-DmBG1-c1  (219) CNS ML-DmBG2-c2  (169) tumorous blood cells mbn2  (140) ovary fGS/OSS  (583) ovary OSC  (826) ovary OSS  (417) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    328 Schneider line 2 Sg4    200 embryonic 1182-4H    337 embryonic GM2    327 embryonic Kc167    356 embryonic S1    418 embryonic S3    315 leg disc CME L1    231 wing disc CME-W2    248 wing disc ML-DmD8    307 wing disc ML-DmD9    319 wing disc ML-DmD16-c3    282 wing disc ML-DmD21    269 wing disc ML-DmD32    348 haltere disc ML-DmD17-c3    325 eye-antennal disc ML-DmD11    237 antennal disc ML-DmD20-c5    180 mixed discs ML-DmD4-c1    212 CNS ML-DmBG1-c1    219 CNS ML-DmBG2-c2    169 tumorous blood cells mbn2    140 ovary fGS/OSS    583 ovary OSC    826 ovary OSS    417 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    328 Schneider line 2 Sg4    200 embryonic 1182-4H    337 embryonic GM2    327 embryonic Kc167    356 embryonic S1    418 embryonic S3    315 leg disc CME L1    231 wing disc CME-W2    248 wing disc ML-DmD8    307 wing disc ML-DmD9    319 wing disc ML-DmD16-c3    282 wing disc ML-DmD21    269 wing disc ML-DmD32    348 haltere disc ML-DmD17-c3    325 eye-antennal disc ML-DmD11    237 antennal disc ML-DmD20-c5    180 mixed discs ML-DmD4-c1    212 CNS ML-DmBG1-c1    219 CNS ML-DmBG2-c2    169 tumorous blood cells mbn2    140 ovary fGS/OSS    583 ovary OSC    826 ovary OSS    417 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (328) Schneider line 2 Sg4  (200) embryonic 1182-4H  (337) embryonic GM2  (327) embryonic Kc167  (356) embryonic S1  (418) embryonic S3  (315) leg disc CME L1  (231) wing disc CME-W2  (248) wing disc ML-DmD8  (307) wing disc ML-DmD9  (319) wing disc ML-DmD16-c3  (282) wing disc ML-DmD21  (269) wing disc ML-DmD32  (348) haltere disc ML-DmD17-c3  (325) eye-antennal disc ML-DmD11  (237) antennal disc ML-DmD20-c5  (180) mixed discs ML-DmD4-c1  (212) CNS ML-DmBG1-c1  (219) CNS ML-DmBG2-c2  (169) tumorous blood cells mbn2  (140) ovary fGS/OSS  (583) ovary OSC  (826) ovary OSS  (417) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (328) Schneider line 2 Sg4  (200) embryonic 1182-4H  (337) embryonic GM2  (327) embryonic Kc167  (356) embryonic S1  (418) embryonic S3  (315) leg disc CME L1  (231) wing disc CME-W2  (248) wing disc ML-DmD8  (307) wing disc ML-DmD9  (319) wing disc ML-DmD16-c3  (282) wing disc ML-DmD21  (269) wing disc ML-DmD32  (348) haltere disc ML-DmD17-c3  (325) eye-antennal disc ML-DmD11  (237) antennal disc ML-DmD20-c5  (180) mixed discs ML-DmD4-c1  (212) CNS ML-DmBG1-c1  (219) CNS ML-DmBG2-c2  (169) tumorous blood cells mbn2  140 ovary fGS/OSS  (583) ovary OSC  (826) ovary OSS  (417) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    328 Schneider line 2 Sg4    200 embryonic 1182-4H    337 embryonic GM2    327 embryonic Kc167    356 embryonic S1    418 embryonic S3    315 leg disc CME L1    231 wing disc CME-W2    248 wing disc ML-DmD8    307 wing disc ML-DmD9    319 wing disc ML-DmD16-c3    282 wing disc ML-DmD21    269 wing disc ML-DmD32    348 haltere disc ML-DmD17-c3    325 eye-antennal disc ML-DmD11    237 antennal disc ML-DmD20-c5    180 mixed discs ML-DmD4-c1    212 CNS ML-DmBG1-c1    219 CNS ML-DmBG2-c2    169 tumorous blood cells mbn2    140 ovary fGS/OSS    583 ovary OSC    826 ovary OSS    417 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    185 cold shock, 4-day adult    141 heat shock, 4-day adult    154 Cadmium 50 mM 6 hrs, larvae L3    53 Cadmium 50 mM 12 hrs, larvae L3    54 Cadmium 50 mM 48 hrs, 4-day adult    162 Cadmium 100 mM 48 hrs, 4-day adult    368 Copper 0.5 mM 12 hrs, larvae L3    73 Copper 15 mM 48 hrs, 4-day adult    444 Zinc 5 mM 12 hrs, larvae L3    84 Zinc 4.5 mM 48 hrs, 4-day adult    192 Ethanol 2.5% 3 hrs, larvae L3    248 Ethanol 5% 3 hrs, larvae L3    47 Ethanol 10% 3 hrs, larvae L3    57 Caffeine 1.5 mg/ml 4 hrs, larvae L3    44 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    317 Caffeine 25 mg/ml 48 hrs, 4-day adult    208 Paraquat 5 mM 48 hrs, 4-day adult    259 Paraquat 10 mM 48 hrs, 4-day adult    193 Rotenone 2 μg 12 hrs, larvae L3    51 Rotenone 8 μg 12 hrs, larvae L3    41 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (185) cold shock, 4-day adult  (141) heat shock, 4-day adult  (154) Cadmium 50 mM 6 hrs, larvae L3  (53) Cadmium 50 mM 12 hrs, larvae L3  (54) Cadmium 50 mM 48 hrs, 4-day adult  (162) Cadmium 100 mM 48 hrs, 4-day adult  (368) Copper 0.5 mM 12 hrs, larvae L3  (73) Copper 15 mM 48 hrs, 4-day adult  (444) Zinc 5 mM 12 hrs, larvae L3  (84) Zinc 4.5 mM 48 hrs, 4-day adult  (192) Ethanol 2.5% 3 hrs, larvae L3  (248) Ethanol 5% 3 hrs, larvae L3  (47) Ethanol 10% 3 hrs, larvae L3  (57) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (44) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (317) Caffeine 25 mg/ml 48 hrs, 4-day adult  (208) Paraquat 5 mM 48 hrs, 4-day adult  (259) Paraquat 10 mM 48 hrs, 4-day adult  (193) Rotenone 2 μg 12 hrs, larvae L3  (51) Rotenone 8 μg 12 hrs, larvae L3  (41) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (185) cold shock, 4-day adult  (141) heat shock, 4-day adult  (154) Cadmium 50 mM 6 hrs, larvae L3    53 Cadmium 50 mM 12 hrs, larvae L3    54 Cadmium 50 mM 48 hrs, 4-day adult  (162) Cadmium 100 mM 48 hrs, 4-day adult  (368) Copper 0.5 mM 12 hrs, larvae L3    73 Copper 15 mM 48 hrs, 4-day adult  (444) Zinc 5 mM 12 hrs, larvae L3    84 Zinc 4.5 mM 48 hrs, 4-day adult  (192) Ethanol 2.5% 3 hrs, larvae L3  (248) Ethanol 5% 3 hrs, larvae L3    47 Ethanol 10% 3 hrs, larvae L3    57 Caffeine 1.5 mg/ml 4 hrs, larvae L3    44 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (317) Caffeine 25 mg/ml 48 hrs, 4-day adult  (208) Paraquat 5 mM 48 hrs, 4-day adult  (259) Paraquat 10 mM 48 hrs, 4-day adult  (193) Rotenone 2 μg 12 hrs, larvae L3    51 Rotenone 8 μg 12 hrs, larvae L3    41 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    185 cold shock, 4-day adult    141 heat shock, 4-day adult    154 Cadmium 50 mM 6 hrs, larvae L3    53 Cadmium 50 mM 12 hrs, larvae L3    54 Cadmium 50 mM 48 hrs, 4-day adult    162 Cadmium 100 mM 48 hrs, 4-day adult    368 Copper 0.5 mM 12 hrs, larvae L3    73 Copper 15 mM 48 hrs, 4-day adult    444 Zinc 5 mM 12 hrs, larvae L3    84 Zinc 4.5 mM 48 hrs, 4-day adult    192 Ethanol 2.5% 3 hrs, larvae L3    248 Ethanol 5% 3 hrs, larvae L3    47 Ethanol 10% 3 hrs, larvae L3    57 Caffeine 1.5 mg/ml 4 hrs, larvae L3    44 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    317 Caffeine 25 mg/ml 48 hrs, 4-day adult    208 Paraquat 5 mM 48 hrs, 4-day adult    259 Paraquat 10 mM 48 hrs, 4-day adult    193 Rotenone 2 μg 12 hrs, larvae L3    51 Rotenone 8 μg 12 hrs, larvae L3    41 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    185 cold shock, 4-day adult    141 heat shock, 4-day adult    154 Cadmium 50 mM 6 hrs, larvae L3    53 Cadmium 50 mM 12 hrs, larvae L3    54 Cadmium 50 mM 48 hrs, 4-day adult    162 Cadmium 100 mM 48 hrs, 4-day adult    368 Copper 0.5 mM 12 hrs, larvae L3    73 Copper 15 mM 48 hrs, 4-day adult    444 Zinc 5 mM 12 hrs, larvae L3    84 Zinc 4.5 mM 48 hrs, 4-day adult    192 Ethanol 2.5% 3 hrs, larvae L3    248 Ethanol 5% 3 hrs, larvae L3    47 Ethanol 10% 3 hrs, larvae L3    57 Caffeine 1.5 mg/ml 4 hrs, larvae L3    44 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    317 Caffeine 25 mg/ml 48 hrs, 4-day adult    208 Paraquat 5 mM 48 hrs, 4-day adult    259 Paraquat 10 mM 48 hrs, 4-day adult    193 Rotenone 2 μg 12 hrs, larvae L3    51 Rotenone 8 μg 12 hrs, larvae L3    41 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (185) cold shock, 4-day adult  (141) heat shock, 4-day adult  (154) Cadmium 50 mM 6 hrs, larvae L3  (53) Cadmium 50 mM 12 hrs, larvae L3  (54) Cadmium 50 mM 48 hrs, 4-day adult  (162) Cadmium 100 mM 48 hrs, 4-day adult  (368) Copper 0.5 mM 12 hrs, larvae L3  (73) Copper 15 mM 48 hrs, 4-day adult  (444) Zinc 5 mM 12 hrs, larvae L3  (84) Zinc 4.5 mM 48 hrs, 4-day adult  (192) Ethanol 2.5% 3 hrs, larvae L3  (248) Ethanol 5% 3 hrs, larvae L3  (47) Ethanol 10% 3 hrs, larvae L3  (57) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (44) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (317) Caffeine 25 mg/ml 48 hrs, 4-day adult  (208) Paraquat 5 mM 48 hrs, 4-day adult  (259) Paraquat 10 mM 48 hrs, 4-day adult  (193) Rotenone 2 μg 12 hrs, larvae L3  (51) Rotenone 8 μg 12 hrs, larvae L3  (41) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (185) cold shock, 4-day adult  141 heat shock, 4-day adult  (154) Cadmium 50 mM 6 hrs, larvae L3    53 Cadmium 50 mM 12 hrs, larvae L3    54 Cadmium 50 mM 48 hrs, 4-day adult  (162) Cadmium 100 mM 48 hrs, 4-day adult  (368) Copper 0.5 mM 12 hrs, larvae L3    73 Copper 15 mM 48 hrs, 4-day adult  (444) Zinc 5 mM 12 hrs, larvae L3    84 Zinc 4.5 mM 48 hrs, 4-day adult  (192) Ethanol 2.5% 3 hrs, larvae L3  (248) Ethanol 5% 3 hrs, larvae L3    47 Ethanol 10% 3 hrs, larvae L3    57 Caffeine 1.5 mg/ml 4 hrs, larvae L3    44 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (317) Caffeine 25 mg/ml 48 hrs, 4-day adult  (208) Paraquat 5 mM 48 hrs, 4-day adult  (259) Paraquat 10 mM 48 hrs, 4-day adult  (193) Rotenone 2 μg 12 hrs, larvae L3    51 Rotenone 8 μg 12 hrs, larvae L3    41 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    185 cold shock, 4-day adult    141 heat shock, 4-day adult    154 Cadmium 50 mM 6 hrs, larvae L3    53 Cadmium 50 mM 12 hrs, larvae L3    54 Cadmium 50 mM 48 hrs, 4-day adult    162 Cadmium 100 mM 48 hrs, 4-day adult    368 Copper 0.5 mM 12 hrs, larvae L3    73 Copper 15 mM 48 hrs, 4-day adult    444 Zinc 5 mM 12 hrs, larvae L3    84 Zinc 4.5 mM 48 hrs, 4-day adult    192 Ethanol 2.5% 3 hrs, larvae L3    248 Ethanol 5% 3 hrs, larvae L3    47 Ethanol 10% 3 hrs, larvae L3    57 Caffeine 1.5 mg/ml 4 hrs, larvae L3    44 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    317 Caffeine 25 mg/ml 48 hrs, 4-day adult    208 Paraquat 5 mM 48 hrs, 4-day adult    259 Paraquat 10 mM 48 hrs, 4-day adult    193 Rotenone 2 μg 12 hrs, larvae L3    51 Rotenone 8 μg 12 hrs, larvae L3    41 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_06 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • LD31194 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015778 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9412-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pupal stage, with Scer\GAL4pnr-MD237 rinGD14212 lethal | recessive rinLA00048 viable rin1 rin2 rinEY05170 viable (with rin1) rin2 viable (with rin2) rin1 Sterility Allele fertile rinEY05170 sterile rinunspecified Other Phenotypes Allele planar polarity defective, with Scer\GAL4hs.2sev rinScer\UAS.cPa planar polarity defective | recessive rin1 rin2 visible rinunspecified visible, with Scer\GAL4hs.2sev rinScer\UAS.cPa visible (with rin1) rin2 visible (with rin2) rin1 visible | recessive rin1 rin2 wild-type rinTub.PP Phenotype manifest in Allele eye rin1 rin2 eye, with Scer\GAL4hs.2sev rinScer\UAS.cPa eye (with rin1) rin2 eye (with rin2) rin1 eye disc rin1 rin2 eye disc, with Scer\GAL4hs.2sev rinScer\UAS.cPa eye photoreceptor cell rin1 rin2 eye photoreceptor cell, with Scer\GAL4hs.2sev rinScer\UAS.cPa ommatidial precursor cluster, with Scer\GAL4hs.2sev rinScer\UAS.cPa ommatidium rin1 rin2 ommatidium, with Scer\GAL4hs.2sev rinScer\UAS.cPa ommatidium (with rin1) rin2 ommatidium (with rin2) rin1 wing rinunspecified
Classical Alleles ( 13 )
For All Classical Alleles Show
Allele of rin Class Mutagen Stocks Known lesion rinLA00048 P-element activity 2 -- rin1 P-element activity 1 Yes rin2 P-element activity 1 Yes rinc02343 piggyBac transposase 1 -- rinEY05170 P-element activity 1 -- rinf05031 piggyBac transposase 1 -- rinNP2563 1 -- rinNP3248 1 -- rinNP5420 1 -- rinc00322 piggyBac transposase 0 -- rinEP920 P-element activity 0 -- rinf04163 piggyBac transposase 0 -- rinunspecified 0 --
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of rin Class Mutagen Stocks Known lesion rinScer\UAS.cPa in vitro construct - regulatory fusion 2 Yes rinGD14212 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes rinGMR.Exel in vitro construct - regulatory fusion 1 Yes rinHMS00269 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes rinTub.PP in vitro construct - regulatory fusion 1 Yes rinKK108430 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes rinNIG.9412R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6169 (Ryder, 2004.4.26) Df(3R)rin2 (Pazman et al., 2000) Df(3R)urd (Pazman et al., 2000)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD14212} NA P{KK108430} NA P{NIG.9412R} NA P{TRiP.HMS00269} NA P{UAS-rin.P} NA characterization construct P{GMR-rin.Exel} NA P{Tub-rin.P} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}rinEP920 NA P{EPgy2}rinEY05170 NA P{Mae-UAS.6.11}rinLA00048 NA insertion of enhancer trap binary system P{GawB}rinNP2563 No P{GawB}rinNP3248 No P{GawB}rinNP5420 No miscellaneous insertions PBac{PB}rinc00322 NA PBac{PB}rinc02343 NA PBac{WH}rinf04163 NA PBac{WH}rinf05031 NA insertion of enhancer trap P{lacW}rin1 No
Gene Ontology: Function, Process & Cellular Component ( 13 unique terms )
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
compound eye photoreceptor fate commitment inferred from mutant phenotype (Pazman et al., 2000) ommatidial rotation inferred from mutant phenotype (Pazman et al., 2000) Ras protein signal transduction inferred from genetic interaction with Rho1 (Pazman et al., 2000)
Cellular Component
CV term Evidence References
catalytic step 2 spliceosome inferred from direct assay (Herold et al., 2009) cytosol inferred from direct assay (Pazman et al., 2000) lipid particle inferred from direct assay (Cermelli et al., 2006) precatalytic spliceosome inferred from direct assay (Herold et al., 2009)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
mRNA binding inferred from sequence or structural similarity (Lasko, 2000) nucleic acid binding inferred from electronic annotation with InterPro:IPR000504 (FlyBase Curators et al., 2004-) nucleotide binding inferred from electronic annotation with InterPro:IPR012677 (FlyBase Curators et al., 2004-) SH3 domain binding inferred from sequence or structural similarity with EMBL:U65313 (FlyBase, 1992-)
Biological Process
CV term Evidence References
mRNA splicing, via spliceosome inferred by curator from GO:0071011|GO:0071013 (Herold et al., 2009) transport inferred from electronic annotation with InterPro:IPR002075 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions rin allele Gene References rin1 Ras85D (Pazman et al., 2000) sev (Pazman et al., 2000) Sos (Pazman et al., 2000) svp (Pazman et al., 2000) rin2 Ras85D (Pazman et al., 2000) Rho1 (Pazman et al., 2000) sev (Pazman et al., 2000) Sos (Pazman et al., 2000) rinunspecified Rho1 (Pazman et al., 2000)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 71089 DroID - A comprehensive database of gene and protein interactions. • FBgn0015778 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 47998
Orthologs
OrthoDB Orthologs (46) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6SF9RQ Dipteran inclusive ortholog search EOG68GWBQ Insect inclusive ortholog search EOG6FQZN4 Arthropod inclusive ortholog search EOG63FFC9 Metazoa inclusive ortholog search EOG644ZCT
Orthologs in Drosophila Species (EOG6SF9RQ)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\rin     Drosophila simulans   Dsim\GD18916 Y   Drosophila sechellia   Dsec\GM24117 Y   Drosophila erecta   Dere\GG19770 Y   Drosophila yakuba   Dyak\GE26283 Y   Drosophila ananassae   Dana\GF17607 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA27297 Y   Drosophila persimilis   Dper\GL23542 Y   Drosophila willistoni   Dwil\GK13947 Y   Drosophila virilis   Dvir\GJ24112 Y   Drosophila mojavensis   Dmoj\GI22064 Y   Drosophila grimshawi   Dgri\GH18527 Y
Orthologs in non-Drosophila Dipterans (EOG68GWBQ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL005528   Anopheles gambiae Malaria mosquito  Agam\AGAP000403   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ801892
Orthologs in non-Dipteran Insects (EOG6FQZN4)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB43301   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG013908   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH25171   Atta cephalotes Leafcutter ant  Acep\ACEP15538   Camponotus floridanus Florida carpenter ant  Cflo\CFLO16398   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL18672   Linepithema humile Argentine ant  Lhum\LH24910   Pogonomyrmex barbatus Red harvester ant  Pbar\PB16280   Solenopsis invicta Red fire ant  Sinv\SINV14763   Acyrthosiphon pisum Pea aphid  Apim\ACYPI006260   Bombyx mori Silkmoth  Bmor\BGIBMGA013447   Pediculus humanus Human body louse  Phum\PHUM407570   Tribolium castaneum Red flour beetle  Tcas\TC000929
Orthologs in non-Insect Arthropods (EOG63FFC9)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Pcbp4
Orthologs in non-Arthropod Metazoa (EOG644ZCT)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_017827gn   Danio rerio Zebrafish  Drer\g3bp1   Danio rerio Zebrafish  Drer\g3bp2   Danio rerio Zebrafish  Drer\zgc:56304   Danio rerio Zebrafish  Drer\ENSDARG00000092127   Xenopus tropicalis Western clawed frog  Xtro\g3bp1   Xenopus tropicalis Western clawed frog  Xtro\g3bp2   Gallus gallus Domestic chicken  Ggal\G3BP1   Gallus gallus Domestic chicken  Ggal\G3BP2   Mus musculus House mouse  Mmus\G3bp2   Mus musculus House mouse  Mmus\G3bp1   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000001595   Rattus norvegicus Norway rat  Rnor\G3bp2   Rattus norvegicus Norway rat  Rnor\G3bp1   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000032820   Homo sapiens Human  Hsap\G3BP2   Homo sapiens Human  Hsap\G3BP1
Human Orthologs (2)
Gene OMIM HGNC Hsap\G3BP2     Hsap\G3BP1
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD18916 Drosophila sechellia Dsec\GM24117 Drosophila erecta Dere\GG19770 Drosophila yakuba Dyak\GE26283 Drosophila ananassae Dana\GF17607 Drosophila pseudoobscura pseudoobscura Dpse\GA27297 Drosophila persimilis Dper\GL23542 Drosophila willistoni Dwil\GK13947 Drosophila virilis Dvir\GJ24112 Drosophila mojavensis Dmoj\GI22064 Drosophila grimshawi Dgri\GH18527
Stocks & Reagents
Stocks Listed in FlyBase ( 16 )
Bloomington	9301 w*; P{Tub-rin.P}T2 9304 w*; P{UAS-rin.P}T6 9309 w*; P{UAS-rin.P}T1 9302 w*; P{lacW}rin1 19850 y1 w67c23; P{EPgy2}rinEY05170
Harvard	- PBac{PB}rinc02343 - PBac{WH}rinf05031
Kyoto	104425 w*; P{GawB}rinNP3248 120048 y* w*; P{Mae-UAS.6.11}rinLA00048 113726 w*; P{GawB}rinNP5420 / TM6, P{UAS-lacZ.UW23-1}UW23-1 112969 w*; P{GawB}rinNP2563 / TM3, Sb1 Ser1
VDRC	v29113 w1118 P{GD14212}v29113
	More stocks available...
Genomic Clones ( 1 )
	BACR03J04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 330 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT27578 LD31194
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT02115 AT02239 AT03611 AT03759 AT04718 AT05465 AT05489 AT05844 AT06656 AT06846 AT07327 AT07864 AT09203 AT10839 AT11579 AT13110 AT13518 AT13765 AT13831 AT14577 AT15460 AT15746 AT15760 AT17282 AT18026 AT18254 AT18440 AT21408 AT22162 AT22256 AT22730 AT23478 AT24003 AT24596 AT24740 AT25188 AT27634 AT27765 AT28560 AT28576 AT28629 AT29661 AT30909 AT31052 AT31415 GH02305 GH07294 GH08075 GH15703 GH22375 GH25724 GM03431 GM05052 GM05132 GM08518 GM08817 GM12883 GM14510 GM23843 GM23901 HL04711 LD15503 LD19302 LD29306 LD29848 LD30886 LD32466 LD33861 LD36122 LD47076 LP02468 LP03103 LP03157 LP03206 LP03902 LP04284 LP05343 LP05963 LP06059 LP08355 LP08467 LP08951 LP15122 LP16083 LP17582 LP20335 LP21758 LP23404 RE01693 RE03114 RE04391 RE04828 RE07649 RE08889 RE08902 RE10075 RE10111 RE10630 RE13833 RE14747 RE18171 RE19491 RE20418 RE23560 RE23713 RE23812 RE24858 RE26844 RE27018 RE28089 RE28188 RE28563 RE28574 RE32913 RE33111 RE34064 RE34285 RE39776 RE40991 RE42958 RE43129 RE44071 RE44103 RE46582 RE49470 RE51370 RE52183 RE55039 RE56289 RE57973 RE69133 RE70576 RE72743 RE73079 RE73080 RE74968 RH01866 RH08989 RH11547 SD06726 SD07720 SD08392 SD12988 SD13821 SD14440 SD18137 SD18417 SD21864 SD24006
Other clones	13835 19037 33055 38591 57185 73433 122104 192263 193187 214221.50 214351.54 214535.53 473599 542442 557151 557725 568965 569104 bs11h03 bs28h10 CK01.7B.H9 CK01.83A.H3 CK01.83C.D3 CK01.85C.G10 CK01.88D.H10 CK01.98C.F9 CK01.101B.B4 CK01.101B.G9 CK01.109D.F7 Dmel_neb_000938_0411_0306 Dmel_neb_001257_0375_3656 Dmel_neb_001287_0175_3676 Dmel_neb_008078_0645_0799 Dmel_neb_010961_0175_1463 EC052625 EK064806 EK066330 EK067659 EK069961 EK076217 EK085438 EK115606 EK115647 EK142846 EK151415 EK195807 EK295416 EK296414 EN00326 EN10623 EN12141 EN12258 EN14251 EN14539 EP00143 EP01317 EP09106 FGA011G04 FGM104E11 FGM231D10 FGM234A08 GM06853 GM08831 RP003017234 RP003037724 RP003038919 RP003070892 RP003072671 RP003072942 RP003076972 RP003087091 RP003088774 RP003100529 RP003101451 RP003103200 RP003105758 RP003106814 RP003115953 RP003118294 RP003120061 RP003124086 RP003137549 RP003137825 RP003143647 RP003143778 RP003150071 RP003151843 RP003155720 RP003158994 RP003160593 RP003167742 RP003172616 RP003175252 RP003180492 RP003180534 RP003184198 RP003188502 RP003189686 RP003190763 RP003191669 RP003194760 RP003197004 RP003199116 RP003200949 RP003206749 RP003214979 RP003217819 RP003220775 RP003228072 RP003231706 RP003233241 RP003237392 RP003243162 RP003244151 RP003244302 RP003247605 RP003248557 RP003249535 RP003252804 RP003263269 RP003277756 RP003279946 RP003281162 RP003301254 RP003302560 RP003304778 RP003306423 RP003308455 RP003309111 RP003310494 RP003312456 RP003316509 RP003320422 RP003326587 RP003329996 RP003338486 RP003344039 RP003345784 RP003345840 RP003350524 RP003353243 RP003354312 RP003357049 RP003376680 RP003395901 RP003415786 RP003422573 RP003427670 RP003432639 RP003440137 RP003441051 RP003451135 RP003458065 RP003458741 RP003465400 RP003473333 RP003474574 RP003500996 RP003508240 RP003520081 RP003532159 RP003533195 RP003533636 RP003551906 RP003554703 RP003556516 RP003562267 RP003573032 RP003579056 RP003609751 RP003638018 RP003658305 RP003666879 RP003667413 RP003680420 RP003680449 RP003681872 RP003682951 UUGC0682
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0015778 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 47998
Antibody Information
	polyclonal (Pazman et al., 2000)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: rin CG9412 (FlyBase, 1996-)
Additional comments	Source for merge of rin CG9412 was sequence comparison (date:000515). (FlyBase, 1996-)
Other Comments
	Mutants show defects in photoreceptor recruitment and ommatidial polarity in the eye. (Pazman et al., 2000) rin is required as an effector in Ras signaling during eye development. (Pazman et al., 2000) rin is required for the normal development of egg chambers. (Haynes and Pazman, 1999) Egg chambers of homozygous mutant females show variable defects, including abnormal numbers of nurse cells, premature degeneration of nurse cell nuclei, small oocytes and abnormal distribution of follicle cells. (Haynes and Pazman, 1999) Transcription unit defined during a molecular analysis of sqd. (Kelley, 1993)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080168 NM_169532 RefSeq (Proteins) • NP_524907 NP_731829 DDBJ / EMBL / GenBank • AA440649 AA950992 AAF54965 AAF68949 AAG22151 AAL13846 AAN13571 AAN13572 AAN13573 AF231031 AI259127 AI259688 AI945356 AI946629 AI947179 AW943068 AY058617 BF490942 CL705802 CZ466368 CZ467879 CZ486695 CZ487626 CZ487627 DU708604 Entrez Gene - A searchable database of RefSeq genes. • 47998 UniProtKB/TrEMBL • Q9NH72 Q9VFT4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Nuclear transport factor 2, Eukaryote (IPR018222) RNA recognition motif domain (IPR000504) Nuclear transport factor 2 (IPR002075) Nucleotide-binding, alpha-beta plait (IPR012677) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD31194
Linkouts
	BioGRID - A database of protein and genetic interactions • 71089 DroID - A comprehensive database of gene and protein interactions. • FBgn0015778 DRSC - Results from RNAi screens. • FBgn0015778 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015778 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9412-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0015778 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 47998 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 47998 modMine - Data generated by the modENCODE project. • FBgn0015778
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	CG9412 (Duncan et al., 2006, Cermelli et al., 2006, Quinones-Coello, 2007, Pisa et al., 2009, Herold et al., 2009, Ni et al., 2010.12.1, Keleman et al., 2009.8.5) cg9412 (Lasko, 2000) Nts (Burnette et al., 1999, Haynes et al., 1997, Kelley, 1993, ) rasp (Pazman and Haynes, 1999, Pazman and Haynes, 1998) rin (Pazman et al., 2000, Cermelli et al., 2006, Costa et al., 2005, Sofola et al., 2007, Quinones-Coello, 2007, Dworkin et al., 2009, Herold et al., 2009, Franco et al., 2011, Japanese National Institute of Genetics, 2012.5.21) Rin (Rasmussen and Kellis, 2007, Khong and Jan, 2011) RIN (Sofola et al., 2007)
Name Synonym	Next to squid (Haynes et al., 1997, Kelley, 1993, ) rasputin (Pazman, 2000.2.2, Haynes and Pazman, 1999, Pazman et al., 2000, Cermelli et al., 2006) Rasputin (Pisa et al., 2009, Beerman and Jongens, 2011, Khong and Jan, 2011, Vognsen and Kristensen, 2012)
Secondary FlyBase IDs
	FBgn0038164
References ( 55 )
Generate a list of	All references relating to this gene ( 55 )
List References by type	Research paper  ( 19 ) Supplementary material  ( 6 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 11 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 5 )
	Krauchunas et al., 2012, Dev. Biol. 370(1): 125--134 Protein phosphorylation changes reveal new candidates in the regulation of egg activation and early embryogenesis in D. melanogaster. [FBrf0219342] Vognsen and Kristensen, 2012, Biochem. Biophys. Res. Commun. 420(1): 188--192 Crystal structure of the Rasputin NTF2-like domain from Drosophila melanogaster. [FBrf0217913] Beerman and Jongens, 2011, Neuroscience 181: 48--66 A non-canonical start codon in the Drosophila fragile X gene yields two functional isoforms. [FBrf0213401] Franco et al., 2011, Mol. Cell. Proteomics 10(5): M110.002188 A Novel Strategy to Isolate Ubiquitin Conjugates Reveals Wide Role for Ubiquitination during Neural Development. [FBrf0213919] Khong and Jan, 2011, J. Virol. 85(4): 1439--1451 Modulation of Stress Granules and P Bodies during Dicistrovirus Infection. [FBrf0212847] Show all research papers ...