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Gene: Dmel\Rab7

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General Information
Symbol
Dmel\Rab7
Species
D. melanogaster
Name
Rab7
Annotation Symbol
CG5915
Feature Type
protein_coding_gene
FlyBase ID
FBgn0015795
Gene Model Status
Current
Stock Availability
17 publicly available
Gene Snapshot
In progress.Contributions welcome.
Other Summaries
Also Known As
DmRab7, Rab-7, DRab7
Key Links
Genomic Location
Cytogenetic map
95D5-95D5
Sequence location
3R:23,993,008..23,995,452 [+]
Recombination map
3-82
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI Genome Data Viewer
UCSC Genome Browser
Ensembl Genome Browser
PopFly Genome Browser
GO Summary Ribbons
Families, Domains and Molecular Function
Gene Group Membership (FlyBase)
Protein Family (UniProt, Sequence Similarities)
-
Protein Domains/Motifs
InterPro
Small GTPase; Small GTP-binding protein domain; P-loop containing nucleoside triphosphate hydrolase
Molecular Function (see GO section for details)
Experimental Evidence
protein-containing complex binding
Predictions / Assertions
GTP binding; GTPase activity
Summaries
Gene Group Membership
RAB GTPASES -
The Rab family are members of the Ras superfamily of small GTPases. Rabs regulate vesicle trafficking including cargo selection, vesicle budding, transport, docking and targeting. They localize to different intracellular compartments directed by specific isoprenylation of C-terminal motifs. (Adapted from PMID:15731001).
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\Rab7 or the JBrowse view of Dmel\Rab7 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.39
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.49
Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Rab7-RA
FBtr0084503
NM_079748
1515
207
Rab7-RB
FBtr0308611
NM_001260347
1269
207
Rab7-RC
FBtr0308612
NM_001260348
1280
207
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Rab7-PA
FBpp0083891
23.3
207
5.06
NP_524472
AAF56218
Rab7-PB
FBpp0300835
23.3
207
5.06
NP_001247276
AFH06594
Rab7-PC
FBpp0300836
23.3
207
5.06
NP_001247277
AFH06595
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

207 aa isoforms: Rab7-PA, Rab7-PB, Rab7-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Rab7 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (29 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
protein-containing complex binding
inferred from physical interaction with FLYBASE:Vps35; FB:FBgn0034708
(Dong et al., 2013)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
GTP binding
inferred from electronic annotation with InterPro:IPR001806, InterPro:IPR003579, InterPro:IPR005225
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
GTPase activity
inferred from sequence or structural similarity
(Jekely, 2003)
inferred from biological aspect of ancestor with PANTHER:PTN001292747
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790
(FlyBase Curators, 2008--)
Biological Process (16 terms)
Terms Based on Experimental Evidence (12 terms)
CV Term
Evidence
References
border follicle cell migration
inferred from mutant phenotype
(Chen et al., 2012)
clathrin-dependent endocytosis involved in vitellogenesis
inferred from direct assay
(Liu et al., 2015)
dsRNA transport
inferred from mutant phenotype
(Saleh et al., 2006)
endocytosis
inferred from mutant phenotype
(Rives et al., 2006)
endosomal transport
inferred from mutant phenotype
(Entchev et al., 2000)
endosomal vesicle fusion
inferred from genetic interaction with UniProtKB:Q9VRX2
(assigned by UniProt )
(Lőrincz et al., 2016)
endosome to lysosome transport
inferred from genetic interaction with FLYBASE:dpp; FB:FBgn0000490
(Entchev et al., 2000)
inferred from mutant phenotype
(Wilkin et al., 2008)
endosome to lysosome transport via multivesicular body sorting pathway
inferred from direct assay
(Yousefian et al., 2013)
exosomal secretion
inferred from mutant phenotype
(Corrigan et al., 2014)
negative regulation of growth of symbiont in host
inferred from mutant phenotype
(Philips et al., 2008)
regulation of Notch signaling pathway
inferred from genetic interaction with FLYBASE:l(2)gd1; FB:FBgn0261983
(Schneider et al., 2013)
wing disc dorsal/ventral pattern formation
inferred from mutant phenotype
(Wilkin et al., 2008)
Terms Based on Predictions or Assertions (6 terms)
CV Term
Evidence
References
endosomal transport
traceable author statement
(Entchev et al., 2000)
endosome to lysosome transport
inferred from biological aspect of ancestor with PANTHER:PTN001178536
(assigned by GO_Central )
(Gaudet et al., 2011)
traceable author statement
(Entchev et al., 2000)
intracellular protein transport
inferred from biological aspect of ancestor with PANTHER:PTN001292747
(assigned by GO_Central )
(Gaudet et al., 2011)
phagosome-lysosome fusion
inferred from biological aspect of ancestor with PANTHER:PTN000635769
(assigned by GO_Central )
(Gaudet et al., 2011)
Rab protein signal transduction
inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790
(FlyBase Curators, 2008--)
inferred from biological aspect of ancestor with PANTHER:PTN001292747
(assigned by GO_Central )
(Gaudet et al., 2011)
vesicle-mediated transport
inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790
(FlyBase Curators, 2008--)
Cellular Component (10 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
cell cortex
inferred from direct assay
(Liu et al., 2015)
late endosome
inferred from direct assay
(Wilkin et al., 2008, Emery et al., 2005, Entchev et al., 2000)
late endosome membrane
inferred from direct assay
(Burgess et al., 2012)
neuronal cell body
inferred from high throughput direct assay
(Chan et al., 2011)
plasma membrane
inferred from high throughput direct assay
(Tan et al., 2009)
synapse
inferred from high throughput direct assay
(Chan et al., 2011)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
late endosome
inferred from biological aspect of ancestor with PANTHER:PTN000635769
(assigned by GO_Central )
(Gaudet et al., 2011)
lysosome
inferred from biological aspect of ancestor with PANTHER:PTN000635769
(assigned by GO_Central )
(Gaudet et al., 2011)
phagocytic vesicle
inferred from biological aspect of ancestor with PANTHER:PTN000635769
(assigned by GO_Central )
(Gaudet et al., 2011)
vacuolar membrane
inferred from biological aspect of ancestor with PANTHER:PTN000635769
(assigned by GO_Central )
(Gaudet et al., 2011)
vesicle
inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790
(FlyBase Curators, 2008--)
Expression Data
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
organism | ubiquitous
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage
embryonic/larval hemocyte
(Rahman et al., 2012)
third instar larval stage
cell
(Yuva-Aydemir et al., 2011)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
organism
(Rahman et al., 2012)
Additional Descriptive Data
Rab7 protein is localized to phagocytic vesicles in hemocytes at an intermediate stage of phagocytosis.
(Rahman et al., 2012)
Marker for
 
late endosome
(Yuva-Aydemir et al., 2011)
Subcellular Localization
CV Term
Evidence
References
cell cortex
inferred from direct assay
(Liu et al., 2015)
late endosome
inferred from direct assay
(Wilkin et al., 2008, Emery et al., 2005, Entchev et al., 2000)
late endosome membrane
inferred from direct assay
(Burgess et al., 2012)
neuronal cell body
inferred from high throughput direct assay
(Chan et al., 2011)
plasma membrane
inferred from high throughput direct assay
(Tan et al., 2009)
synapse
inferred from high throughput direct assay
(Chan et al., 2011)
Expression Deduced from Reporters
Reporter: PBac{I-SceI(FRT.Rab7-GAL4.ORF(loxP.3xP3-RFP))}
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
neuron | subset of embryonic/larval brain
(Chan et al., 2011)
glial cell | subset of embryonic/larval brain
(Chan et al., 2011)
embryonic/larval salivary gland | restricted
(Jin et al., 2012, Chan et al., 2011)
neuron | subset of ventral nerve cord
(Chan et al., 2011)
wing disc | restricted
(Jin et al., 2012, Chan et al., 2011)
eye disc | restricted
(Jin et al., 2012, Chan et al., 2011)
neuropil glial sheath
(Jin et al., 2012)
Bolwig organ | restricted
(Jin et al., 2012)
embryonic/larval mushroom body
(Jin et al., 2012)
embryonic/larval optic stalk sheath cell
(Jin et al., 2012)
ventral thoracic disc | restricted
(Jin et al., 2012)
pupal stage P6 -- P7
neuron | subset of pupal brain

Comment: 30-40h APF

(Chan et al., 2011)
mushroom body

Comment: 30-40h APF

(Jin et al., 2012, Chan et al., 2011)
neuropil glial sheath

Comment: 30-40h APF

(Jin et al., 2012)
glial cell of second optic chiasma | intense

Comment: 30-40h APF

(Jin et al., 2012)
neuron of adult optic lobe | faint

Comment: 30-40h APF

(Jin et al., 2012)
eye photoreceptor cell | intense

Comment: 30-40h APF

(Jin et al., 2012)
adult stage
neuron | subset of adult brain | ubiquitous
(Chan et al., 2011)
ensheathing neuropil associated glial cell
(Jin et al., 2012)
adult inner optic chiasma giant glial cell | intense
(Jin et al., 2012)
neuron of adult optic lobe
(Jin et al., 2012)
adult mushroom body
(Jin et al., 2012)
adult antennal lobe
(Jin et al., 2012)
adult insulin secreting cell of pars intercerebralis
(Jin et al., 2012)
neuron of lamina | intense
(Jin et al., 2012)
ellipsoid body
(Jin et al., 2012)
fan-shaped body
(Jin et al., 2012)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Rab7 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs and Phenotypes
Classical and Insertion Alleles ( 4 )
For All Classical and Insertion Alleles Show
 
Allele of Rab7
Class
Mutagen
Associated Insertion
Stocks
Known lesion
Rab7EYFP
1
Yes
Rab7d1
amorphic allele - molecular evidence, amorphic allele - genetic evidence
0
Yes
Rab7EY10675
1
Yes
Rab7Gal4-KO
amorphic allele - molecular evidence
0
Yes
Other relevant insertions
Transgenic Constructs ( 31 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Rab7
Allele of Rab7
Mutagen
Associated Transgenic Construct
Stocks
Rab7UAS.GFP
2
Rab7T22N.UASp.YFP
2
Rab7GD11800
2
Rab7UASp.YFP
2
Rab7Q67L.UASp.YFP
3
Rab7αTub84B.T:Avic\GFP-EYFP
0
Rab7Q67L.UAS
1
Rab7JF02377
1
Rab7T22N.UAS
0
Rab7TN.Scer\UAS
0
Rab7dsRNA.Scer\UAS
0
Rab7Q67L.UAS.N.EGFP
0
Rab7TN.Scer\FRT.Scer\UAS
0
Rab7TKO.GS00598
1
Rab7dsRNA.Scer\FRT.Scer\UAS
0
Rab7dsRNA.UAS.cUa
0
Rab7dsRNA.UAS.V22
0
Rab7HMC03874
0
Rab7K157N.UAS.Venus
0
Rab7L129F.UAS.Venus
0
Rab7N161T.UAS.Venus
0
Rab7ninaE.DsRed(Unk)
0
Rab7Q67L.UAS.Venus
0
Rab7S-B.7
0
Rab7S-B.14
0
Rab7T22N.UAS.Venus
0
Rab7UAS.N.GFP
0
Rab7UAS.Venus
0
Rab7UASp.Tag:MYC
0
Rab7V162M.UAS.Venus
0
Rab7βTub85D.GFP
0
Transgenic constructs containing regulatory region of Rab7
characterization construct
Name
Expression Data
P{Pug.9.R}
NA
P{PugD.K-B.10}
NA
GAL4 construct
Name
Expression Data
PBac{I-SceI(FRT.Rab7-GAL4.ORF(loxP.3xP3-RFP))}
Yes
Deletions and Duplications ( 1 )
Summary of Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | recessive, with Scer\GAL4Rab7-Gal4-KO
lethal - all die before end of P-stage
lethal - all die before end of pupal stage | recessive
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4Rab7-Gal4-KO
viable, with Scer\GAL4tin.CΔ4
viable (with Rab7Gal4-KO), with Scer\GAL4Rab7-Gal4-KO
viable (with Rab7K157N.UAS.Venus), with Scer\GAL4Rab7-Gal4-KO
viable (with Rab7L129F.UAS.Venus), with Scer\GAL4Rab7-Gal4-KO
viable (with Rab7N161T.UAS.Venus), with Scer\GAL4Rab7-Gal4-KO
viable (with Rab7Q67L.UAS.Venus), with Scer\GAL4Rab7-Gal4-KO
viable (with Rab7T22N.UAS.Venus), with Scer\GAL4Rab7-Gal4-KO
viable (with Rab7UAS.Venus), with Scer\GAL4Rab7-Gal4-KO
viable (with Rab7V162M.UAS.Venus), with Scer\GAL4Rab7-Gal4-KO
Sterility
Allele
fertile
Other Phenotypes
Allele
cell migration defective, with Scer\GAL4slbo.2.6
immune response defective | adult stage, with Scer\GAL4Hml.Δ
increased cell number | adult stage, with Scer\GAL4NP5130
neuroanatomy defective, with Scer\GAL4da.G32
neuroanatomy defective, with Scer\GAL4en-e16E
neuroanatomy defective | adult stage | dominant
neuroanatomy defective | adult stage | progressive | somatic clone
neurophysiology defective | adult stage | dominant
neurophysiology defective | adult stage | progressive | somatic clone
neurophysiology defective | larval stage | somatic clone
short lived, with Scer\GAL4Mef2.PR
visible, with Scer\GAL4en-e16E
Phenotype manifest in
Allele
adult midgut epithelium, with Scer\GAL4NP5130
autolysosome | third instar larval stage (with Df(3R)Exel6196)
autophagosome | larval stage | somatic clone, with Scer\GAL4Act.PU
autophagosome | third instar larval stage
autophagosome | third instar larval stage (with Df(3R)Exel6196)
border follicle cell, with Scer\GAL4slbo.2.6
dorsal multidendritic neuron ddaC, with Scer\GAL4en-e16E
egg chamber, with Scer\GAL4VP16.mat.αTub67C
embryonic/larval fat body | larval stage | somatic clone, with Scer\GAL4Act.PU
embryonic/larval fat body | third instar larval stage
embryonic/larval fat body | third instar larval stage (with Df(3R)Exel6196)
embryonic/larval hemocyte | supernumerary | third instar larval stage
endosome, with Scer\GAL4hh-Gal4
endosome, with Scer\GAL4ptc-559.1
enteroblast of posterior adult midgut epithelium, with Scer\GAL4NP5130
extracellular exosome, with Scer\GAL4dsx.KI
eye disc, with Scer\GAL4da.G32
glial cell, with Scer\GAL4da.G32
hemocyte | adult stage, with Scer\GAL4Hml.Δ
intestinal stem cell of posterior adult midgut epithelium, with Scer\GAL4NP5130
late endosome, with Scer\GAL4unspecified
lysosome, with Scer\GAL4CY2
male accessory gland secondary cell, with Scer\GAL4dsx.KI
mitochondrial derivative, with Scer\GAL4VP16.mat.αTub67C
multivesicular body, with Scer\GAL4ptc-559.1
oocyte, with Scer\GAL4VP16.mat.αTub67C
phagocytic vesicle, with Scer\GAL4Hml.Δ
photoreceptor
photoreceptor | progressive | somatic clone
rhabdomere
rhabdomere | progressive | somatic clone
synapse
synapse | progressive | somatic clone
vesicle, with Scer\GAL4eg-Mz360
vesicle | adult stage | female, with Scer\GAL4VP16.mat.αTub67C
wing, with Scer\GAL4unspecified
wing blade posterior compartment, with Scer\GAL4en-e16E
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\RAB7A
13 of 15
Yes
Yes
 
 
Hsap\RAB9A
3 of 15
No
No
 
Hsap\RAB7B
2 of 15
No
Yes
Hsap\RAB9B
2 of 15
No
No
 
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Rab7
13 of 15
Yes
Yes
Mmus\Rab7b
2 of 15
No
Yes
Mmus\Rab9b
1 of 15
No
No
Mmus\Rab9
1 of 15
No
No
Rattus norvegicus (Norway rat) (4)
Rnor\Rab7a
12 of 13
Yes
Yes
Rnor\Rab7b
3 of 13
No
Yes
Rnor\Rab9a
2 of 13
No
No
Rnor\Rab9b
2 of 13
No
No
Xenopus tropicalis (Western clawed frog) (5)
Xtro\rab7a
11 of 12
Yes
Yes
Xtro\MGC75872
3 of 12
No
Yes
Xtro\rab7b
2 of 12
No
Yes
Xtro\rab9a
2 of 12
No
No
Xtro\rab9b
2 of 12
No
No
Danio rerio (Zebrafish) (6)
Drer\rab7
13 of 15
Yes
Yes
Drer\zgc:91909
13 of 15
Yes
Yes
Drer\zgc:100918
11 of 15
No
Yes
Drer\si:dkey-13a21.4
4 of 15
No
Yes
Drer\rab9a
2 of 15
No
No
Drer\rab9b
2 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\rab-7
13 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (8)
Atha\RABG3c
9 of 9
Yes
Yes
Atha\RABG3d
9 of 9
Yes
Yes
Atha\RAB7B
8 of 9
No
Yes
Atha\RABG3E
8 of 9
No
Yes
Atha\RABG3A
7 of 9
No
Yes
Atha\RABG3B
7 of 9
No
Yes
Atha\RAB7A
3 of 9
No
Yes
Atha\RABG1
3 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\YPT7
14 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\ypt7
11 of 12
Yes
Yes
Spom\ypt71
4 of 12
No
Yes
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190F8S )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\Rab7
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00008975
Drosophila simulans
Dsim\GD21052
Drosophila sechellia
Dsec\GM26547
Drosophila erecta
Dere\GG11243
Drosophila yakuba
Dyak\GE23436
Drosophila ananassae
Dana\GF17031
Drosophila pseudoobscura pseudoobscura
Dpse\GA29225
Drosophila persimilis
Dper\GL23391
Drosophila willistoni
Dwil\GK14177
Drosophila virilis
Dvir\GJ24655
Drosophila mojavensis
Dmoj\GI24142
Drosophila grimshawi
Dgri\GH18481
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150AO5 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17022733
Glossina morsitans
Tsetse fly
Gmor\GMOY004702
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_05517
Mayetiola destructor
Hessian fly
Mdes\Mdes000887
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL003503
Anopheles darlingi
American malaria mosquito
Adar\ADAC003435
Anopheles gambiae
Malaria mosquito
Agam\AGAP001617
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ009089
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0D6F )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA007712
Danaus plexippus
Monarch butterfly
Dple\DPOGS204401-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL015683
Apis florea
Little honeybee
Aflo\2829132580
Apis mellifera
Western honey bee
Amel\GB42753
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP13361
Bombus terrestris
Buff-tailed bumblebee
Bter\15206513
Linepithema humile
Argentine ant
Lhum\LH17129
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG003382
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_08397
Tribolium castaneum
Red flour beetle
Tcas\TC034818
Pediculus humanus
Human body louse
Phum\PHUM025720
Rhodnius prolixus
Kissing bug
Rpro\RPRC008314
Cimex lectularius
Bed bug
Clec\CLEC001212
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI002607
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_14776
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0D47 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR014183
Strigamia maritima
European centipede
Smar\SMAR011259
Ixodes scapularis
Black-legged tick
Isca\ISCW021969
Stegodyphus mimosarum
African social velvet spider
Smim\KFM70314.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur26g00240
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_231190
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0JIV )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Rab7
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Rab9
Ciona intestinalis
Vase tunicate
Cint\LOC100178332
Ciona intestinalis
Vase tunicate
Cint\LOC100183094
Gallus gallus
Domestic chicken
Ggal\RAB9A
Gallus gallus
Domestic chicken
Ggal\RAB7A
Gallus gallus
Domestic chicken
Ggal\RAB9B
Human Disease Model Data
FlyBase Human Disease Model Reports
Alleles Reported to Model Human Disease (Disease Ontology)
Download
Models ( 1 )
Allele
Disease
Evidence
References
Rab7Gal4-KO
model of  Charcot-Marie-Tooth disease type 2
inferred from mutant phenotype
(Cherry et al., 2013)
Interactions ( 2 )
Allele
Disease
Interaction
References
Rab7UAS.GFP
ameliorates  Parkinson's disease
modeled by Hsap\SNCAA53T.UAS
(Dinter et al., 2016)
Rab7T22N.UASp.YFP
ameliorates  tauopathy
modeled by Hsap\MAPTGMR.Ex.PJ
(Bakhoum et al., 2014)
Comments ( 1 )
 
The Charcot-Marie-Tooth 2B disease is a genetically dominant disorder as all patients contain one wild-type copy and one mutant copy of the human Hsap\RAB7A gene. It has been proposed that the mutant forms of Hsap\RAB7A that are seen in Charcot-Marie-Tooth 2B disease patients are gain of function mutations which cause the adult onset neurodegeneration characteristic of the disease. However, studies in a Drosophila model suggest that the neurodegeneration seen in Charcot-Marie-Tooth 2B disease may be caused by loss of normal Hsap\RAB7A function in the patients rather than by the presence of the mutant protein: mutant flies that completely lack function of the Drosophila Rab7 gene in the eye show adult onset neurodegeneration, while flies overexpressing mutant forms of Rab7 which have been identified in Charcot-Marie-Tooth 2B disease patients (the flies express either a mutant form of Hsap\RAB7A or express the equivalent mutations in the Drosophila Rab7 ortholog) do not show neurodegeneration.
(Cherry et al., 2013)
Human Orthologs (via DIOPT v7.1)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
Complementation?
Transgene?
RAB7A; RAB7A, member RAS oncogene family
13 of 15
602298
 
RAB9A; RAB9A, member RAS oncogene family
3 of 15
300284
     
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Dmel gene
    Ortholog showing functional complementation
    Supporting References
    Rab7
    Hsap\RAB7A
    (Cherry et al., 2013)
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser
    View in Interactions Browser
    Please look at the Interaction Group reports for full details of the physical interactions
    protein-protein
    Interacting group
    Assay
    References
    Rab7 - Aprt
    experimental knowledge based
    (Guruharsha et al., 2011)
    Rab7 - CCT6
    experimental knowledge based
    (Guruharsha et al., 2011)
    Rab7 - CCT8
    experimental knowledge based
    (Guruharsha et al., 2011)
    Rab7 - CG11534
    pull down, peptide massfingerprinting
    (Gillingham et al., 2014)
    Rab7 - CG12012
    experimental knowledge based
    (Guruharsha et al., 2011)
    Rab7 - CG1416
    experimental knowledge based
    (Guruharsha et al., 2011)
    Rab7 - CG2064
    experimental knowledge based
    (Guruharsha et al., 2011)
    Rab7 - CG33303
    experimental knowledge based
    (Guruharsha et al., 2011)
    Rab7 - CG6613
    pull down, peptide massfingerprinting, two hybrid, anti tag western blot
    (Lőrincz et al., 2017, Gillingham et al., 2014, Gillingham et al., 2014, Gillingham et al., 2014)
    Rab7 - CG9662
    experimental knowledge based
    (Guruharsha et al., 2011)
    Rab7 - Cyp12d1-p
    experimental knowledge based
    (Guruharsha et al., 2011)
    Rab7 - E(spl)m8-HLH
    experimental knowledge based
    (Guruharsha et al., 2011)
    Rab7 - Epg5
    pull down, peptide massfingerprinting
    (Gillingham et al., 2014)
    Rab7 - Fnta
    pull down, peptide massfingerprinting
    (Gillingham et al., 2014)
    Rab7 - Gdi
    anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based, pull down
    (Gillingham et al., 2014, Rhee et al., 2014)
    Rab7 - KdelR
    experimental knowledge based
    (Guruharsha et al., 2011)
    Rab7 - Lrrk
    anti tag coimmunoprecipitation, anti tag western blot
    (Dodson et al., 2012)
    Rab7 - Mcad
    experimental knowledge based
    (Guruharsha et al., 2011)
    Rab7 - Mec2
    experimental knowledge based
    (Guruharsha et al., 2011)
    Rab7 - Mer
    anti tag coimmunoprecipitation, peptide massfingerprinting
    (Kwon et al., 2013)
    Rab7 - Mon1
    protein three hybrid
    (Hegedűs et al., 2016)
    Rab7 - Rab1
    experimental knowledge based
    (Guruharsha et al., 2011)
    Rab7 - Rab14
    experimental knowledge based
    (Guruharsha et al., 2011)
    Rab7 - Rab2
    experimental knowledge based
    (Guruharsha et al., 2011)
    Rab7 - Rab5
    experimental knowledge based
    (Guruharsha et al., 2011)
    Rab7 - Rab6
    experimental knowledge based
    (Guruharsha et al., 2011)
    Rab7 - Rpn1
    experimental knowledge based
    (Guruharsha et al., 2011)
    Rab7 - ScsβG
    experimental knowledge based
    (Guruharsha et al., 2011)
    Rab7 - Sec24AB
    pull down, peptide massfingerprinting
    (Gillingham et al., 2014)
    Rab7 - Vps13
    anti bait coimmunoprecipitation, western blot
    (Vonk et al., 2017)
    Rab7 - Vps35
    pull down, anti tag western blot
    (Dong et al., 2013)
    Rab7 - c11.1
    pull down, peptide massfingerprinting, two hybrid
    (Gillingham et al., 2014, Gillingham et al., 2014, Gillingham et al., 2014)
    Rab7 - fliI
    pull down, peptide massfingerprinting
    (Gillingham et al., 2014)
    Rab7 - jagn
    experimental knowledge based
    (Guruharsha et al., 2011)
    Rab7 - wal
    experimental knowledge based
    (Guruharsha et al., 2011)
    Rab7 - zip
    pull down, peptide massfingerprinting
    (Gillingham et al., 2014)
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement
    View in Interactions Browser
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Rab7
    suppressible
    EndoB
    (Tsai et al., 2014)
    Rab7
    enhanceable
    Lrrk
    (Dodson et al., 2012)
    Rab7
    suppressible
    Lrrk
    (Dodson et al., 2012)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    egr
    suppressible
    Rab7
    (Ruan et al., 2016)
    egr
    enhanceable
    Rab7
    (Ruan et al., 2016)
    FIG4
    enhanceable
    Rab7
    (Bharadwaj et al., 2016)
    FIG4
    suppressible
    Rab7
    (Bharadwaj et al., 2016)
    l(2)gd1
    suppressible
    Rab7
    (Schneider et al., 2013)
    Lrrk
    suppressible
    Rab7
    (Dodson et al., 2012)
    Ocrl
    suppressible
    Rab7
    (Del Signore et al., 2017)
    Osbp
    suppressible
    Rab7
    (Ma et al., 2012)
    Pi3K59F
    enhanceable
    Rab7
    (O'Farrell et al., 2017)
    Rab2
    suppressible
    Rab7
    (Lőrincz et al., 2017)
    RhoGAP68F
    enhanceable
    Rab7
    (de Madrid et al., 2015)
    sky
    suppressible
    Rab7
    (Fernandes et al., 2014)
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    External Data
    Linkouts
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3R
    Recombination map
    3-82
    Cytogenetic map
    95D5-95D5
    Sequence location
    3R:23,993,008..23,995,452 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    95D5-95D5
    Limits computationally determined from genome sequence between P{PZ}l(3)0468404684 and P{PZ}Atg600096
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    95D1-95D6
    (Entchev, 2000.5.3, Rong, 1998.7.21)
    95D-95D
    (Ozaki, 1999.12.9)
    Experimentally Determined Recombination Data
    Location
    3-82
    (FlyBase, 2016)
    3-82.5
    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (17)
    Genomic Clones (22)
    cDNA Clones (219)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     
    monoclonal
    (Riedel et al., 2016)
    polyclonal
    (Chinchore et al., 2009, Tanaka and Nakamura, 2008)
    Commercially Available Antibodies
     
    Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for identity of: Rab7 CG5915
    (Kodira, 1999.11)
    Source for database merge of
    Additional comments
    Other Comments
    Rab7 is required for the normal clearance of the paternal mitochondrial derivatives in developing embryos.
    (Politi et al., 2014)
    dsRNA has been made from templates generated with primers directed against this gene.
    (Kouranti et al., 2006)
    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 53 )
    Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    InterPro - A database of protein families, domains and functional sites
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center cDNA clones
    DPiM - Drosophila Protein interaction map
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    FlyMine - An integrated database for Drosophila genomics
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    KEGG Genes - Molecular building blocks of life in the genomic space.
    modMine - A data warehouse for the modENCODE project
    Synonyms and Secondary IDs (17)
    Reported As
    Symbol Synonym
    AAF56218
    (Armstrong, 2000)
    CG5915
    (Yamaguchi and Takashima, 2018, Kolkhof et al., 2017, Dunst et al., 2015, Hoffmann et al., 2013, Krahmer et al., 2013, Cammarato et al., 2011, Ni et al., 2010.12.1, Perkins et al., 2009.3.31, Sinka et al., 2008, Zhang et al., 2007, Cermelli et al., 2006, Dorer et al., 2006, Saleh et al., 2006, Colicelli, 2004, Fulton et al., 2001, Verstreken and Bellen, 2000.9.4)
    DRAB7
    (Kohno et al., 1994)
    DRab7
    (Rives et al., 2006, Entchev et al., 2000)
    Dm Rab7
    (Jekely, 2003)
    DmRab7
    (Fetchko et al., 2002, Pereira-Leal and Seabra, 2001, Pereira-Leal and Seabra, 2001)
    Drab7
    (Satoh et al., 1997)
    O76742
    (Rojas et al., 2012)
    RAB7
    (Baron, 2012, Dorer et al., 2006, Rong and Golic, 1997)
    Rab-7
    (Akbar et al., 2011, Gorski et al., 2003)
    Rab-r7
    Rab7
    (Csizmadia et al., 2018, Li et al., 2018, Liu et al., 2018, Yamaguchi and Takashima, 2018, Akbergenova and Littleton, 2017, Beer and Wehman, 2017, Bussmann and Storkebaum, 2017, Court et al., 2017, Coutinho-Budd et al., 2017, Del Signore et al., 2017, Fujita et al., 2017, Galluzzi et al., 2017, Kamalesh et al., 2017, Lőrincz et al., 2017, O'Farrell et al., 2017, Sato and Sato, 2017, Sellin et al., 2017, Transgenic RNAi Project members, 2017-, Vonk et al., 2017, Bharadwaj et al., 2016, Caviglia et al., 2016, Dinter et al., 2016, Fang et al., 2016, Hegedűs et al., 2016, Iwanami et al., 2016, Lőrincz et al., 2016, Meehan et al., 2016, Nagy et al., 2016, Pueyo et al., 2016, Riedel et al., 2016, Deivasigamani et al., 2015, de Madrid et al., 2015, Jean et al., 2015, Lee et al., 2015, Liu et al., 2015, Parchure et al., 2015, Portela et al., 2015, Sopko et al., 2015, Van Bortle et al., 2015, Wang et al., 2015, White et al., 2015, Bakhoum et al., 2014, Chen et al., 2014, Corrigan et al., 2014, Couturier et al., 2014, Dodson et al., 2014, Garg and Wu, 2014, Gillingham et al., 2014, Gillingham et al., 2014, Gillingham et al., 2014, Han et al., 2014, Janssens et al., 2014, Liu et al., 2014, Parsons et al., 2014, Politi et al., 2014, Shimizu et al., 2014, Szatmári et al., 2014, Thomas and Strutt, 2014, Tsai et al., 2014, Valzania et al., 2014, Wang et al., 2014, Abdallah et al., 2013, Aoyama et al., 2013, Bader et al., 2013, Bechtel et al., 2013, Cherry et al., 2013, Couturier et al., 2013, Dong et al., 2013, Dong et al., 2013, Fan et al., 2013, Gross et al., 2013, Hermle et al., 2013, Hoffmann et al., 2013, Krahmer et al., 2013, Kwon et al., 2013, Kwon et al., 2013, Macleod et al., 2013, Pepperl et al., 2013, Petzoldt et al., 2013, Sanchez-Garcia et al., 2013, Satoh et al., 2013, Schneider et al., 2013, Thomae et al., 2013, Xiong and Bellen, 2013, Yousefian et al., 2013, Zuo et al., 2013, Burgess et al., 2012, Capilla et al., 2012, Chen et al., 2012, Dodson et al., 2012, Gailite et al., 2012, Gault et al., 2012, Haberman et al., 2012, Hibbard and O'Tousa, 2012, Jean et al., 2012, Kametaka et al., 2012, Laflamme et al., 2012, Lloyd et al., 2012, Ma et al., 2012, Nezis, 2012, Rahman et al., 2012, Singh and Mlodzik, 2012, Wang et al., 2012, Wong et al., 2012, Xia et al., 2012, Xiong et al., 2012, Yamakawa et al., 2012, Ben El Kadhi et al., 2011, Bhuin and Roy, 2011, Burgess et al., 2011, Dalton et al., 2011, Gilbert et al., 2011, Mateus et al., 2011, Mitra et al., 2011, Otani et al., 2011, Ribeiro et al., 2011, Sun et al., 2011, Swetha et al., 2011, Tanaka et al., 2011, Tjota et al., 2011, Wang and Pai, 2011, Yuva-Aydemir et al., 2011, Becam et al., 2010, Cheli et al., 2010, Haberman et al., 2010, Haglund et al., 2010, Ho et al., 2010, Janssens et al., 2010, Kawahashi and Hayashi, 2010, Kim et al., 2010, Li et al., 2010, Lone et al., 2010, Midorikawa et al., 2010, Mottola et al., 2010, Mukai et al., 2010, Pirraglia et al., 2010, Stempfle et al., 2010, Velichkova et al., 2010, Williamson et al., 2010, Williamson et al., 2010, Abe et al., 2009, Akbar et al., 2009, Dworkin et al., 2009, Fetting et al., 2009, Gupta et al., 2009, Khaliullina et al., 2009, Polevoy et al., 2009, Soukup et al., 2009, Tan et al., 2009, Thomas et al., 2009, Warner and Longmore, 2009, Yan et al., 2009, Albertson et al., 2008, Chang et al., 2008, Denef et al., 2008, Harris and Tepass, 2008, Miura et al., 2008, Philips et al., 2008, Sinka et al., 2008, Strutt and Strutt, 2008, Tanaka and Nakamura, 2008, Velichkova et al., 2008, Wilkin et al., 2008, Yu et al., 2008, Bakal et al., 2007, Coutelis and Ephrussi, 2007, Curtis et al., 2007, Jiang et al., 2007, Korolchuk et al., 2007, Stuart et al., 2007, Tsarouhas et al., 2007, Tsruya et al., 2007, Zhang et al., 2007, Zhang et al., 2007, Bokel et al., 2006, Cermelli et al., 2006, Gallagher and Knoblich, 2006, Glittenberg et al., 2006, Hennig et al., 2006, Kouranti et al., 2006, Rusten et al., 2006, Saleh et al., 2006, Seto and Bellen, 2006, Sweeney et al., 2006, Sweeney et al., 2006, Emery et al., 2005, Hutterer and Knoblich, 2005, Jutras et al., 2005, Lu and Bilder, 2005, Somers and Chia, 2005, Strigini, 2005, Wu et al., 2005, Guha et al., 2003)
    Rab7A
    (Jolly et al., 2016)
    dRab7
    (Gupta et al., 2014)
    drab7
    (Gupta et al., 2014)
    rab7
    (Lammers et al., 2017, Ruan et al., 2016, Xu and Wang, 2016, Chance and Bashaw, 2015, Fernandes et al., 2014, Cherry et al., 2013, Lee et al., 2013, van den Brink et al., 2013, Jin et al., 2012, Troost et al., 2012, Chan et al., 2011, Assaker et al., 2010, McPhee et al., 2010, Chinchore et al., 2009, Lim and Kraut, 2009, O'Connor-Giles et al., 2008, Akbar et al., 2007, Devergne et al., 2007, Walthall et al., 2007, Jaekel and Klein, 2006, Rong, 1998.7.21)
    Name Synonyms
    Rab-protein 7
    (Cammarato et al., 2011)
    Rab7
    Secondary FlyBase IDs
      Datasets (1)
      Study focus (1)
      Experimental Role
      Project
      Project Type
      Title
      • bait_protein
      Rab_Effectors_interaction_map
      Interaction map generated by purification of most Rab factors, with identification of copurifying effectors by mass spectrometry.
      References (313)