l(2)08323, wrt, warthog, DmRab6
small GTPase required for membrane trafficking - required for organization and growth of the egg chamber and the polarization of the microtubule cytoskeleton and localization of mRNA - involved in trafficking Notch protein during bristle development and rhodopsin the the eye
Gene model reviewed during 5.51
Gene model reviewed during 5.43
Gene model reviewed during 5.56
Interacts with Rich and Act5C. Interacts with BicD (via C-terminal domain). Interacts (in GTP-bound) with GCC1/CG10703 and cbs.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Rab6 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Rab6 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA has been made from templates generated with primers directed against this gene.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
The Rab6 gene is an essential gene, however, it has limited effects on development beyond the larval stage. Only the mechanosensory bristles on the head, notum and scutellum are affected by Rab6 mutations.
Mutants isolated in a screen of the second chromosome identifying genes affecting disc morphology.
Rab6 is required for anterograde transport of rhodopsin through the ER-Golgi complex.
Isolated from a Drosophila head cDNA library.