A Database of Drosophila Genes & Genomes

FB2012_01, released January 20th, 2012
 

Gene Dmel\Rbf

General Information
SymbolDmel\RbfSpeciesD. melanogaster
NameRetinoblastoma-family proteinAnnotation symbolCG7413
Feature typeprotein_coding_geneFlyBase IDFBgn0015799
Gene Model StatusCurrent Stock availability 9 publicly available
Also Known AsRBF1, Rb, EG:34F3.3, dRBF
Genomic Location
Chromosome (arm)XRecombination map
Cytogenetic map1C5-1C5Sequence locationX:691,121..695,490 [-]

Genomic Maps

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modENCODE GBrowse
detailed view
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Automatically generated summary

See sections below for more information
The gene Retinoblastoma-family protein is referred to in FlyBase by the symbol Dmel\Rbf (CG7413, FBgn0015799). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; transcription factor binding; transcription regulatory region DNA binding. There is experimental evidence for 12 unique biological process terms, many of which group under: biological regulation; cell cycle; cell cycle process; negative regulation of cellular biosynthetic process; regulation of apoptosis; negative regulation of metabolic process; negative regulation of biosynthetic process; regulation of cell proliferation; regulation of S phase of mitotic cell cycle; regulation of DNA binding. 58 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; adult segment; organ system; external compound sense organ; thoracic segment; integumentary plate; cell part; non-connected developing system; cell cycle; imaginal precursor. It has one annotated transcript and one annotated polypeptide. Protein features are: Cyclin-like; Domain of unknown function DUF3452, retinoblastoma-associated; Retinoblastoma-associated protein, A-box; Retinoblastoma-associated protein, B-box. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval salivary gland, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1623479_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Rbf. Gene sequence location is X:691121..695490.

External Summaries
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Description
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This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).
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FB2011_10
References
FB2012_01
References
Sequence features
Controlled Vocabulary Terms
All updates Click here to see a list of all updates to this record from FB2010_08 and on.
hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
1C5-1C5  
Limits computationally determined from genome sequence between P{EP}sdkEP369 and P{EP}EP1600&P{EP}EP1498  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
1C-1D  
(determined by in situ hybridisation)  
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
hide Gene Model & Products
Please see the GBrowse view of Dmel\Rbf for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
detailed view FBtr0070140 FBtr0070146 FBtr0070145 FBtr0290198 FBtr0305568 FBpp0070135 FBpp0070141 FBpp0070140 FBti0076911 FBti0054134 FBti0039421 FBti0071470 FBti0131356
Comments on Gene Model
DGC clone GH05946 appears problematic: incomplete CDS
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
FBtr0070146
  3599
  845
Additional Transcript Data & Comments
Reported size (kB)
2.593 (unknown)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
Rbf-PA  
FBpp0070141  
96.8  
845  
6.54  
Additional Polypeptide Data & Comments
Reported size (kDa)
797 (aa); 95 (kD observed)
Comments
External Data
Linkouts
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
hide Mapped Features
Mapped Features have been reorganized, please see this article for details.
Additional mapped features and mutations can be found on GBrowse or related reports.
Type
Symbol & Location
Additional Notes
References
hide External Data
Linkouts
Crossreferences
hide Expression Data
hideTranscript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
hidePolypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
hide High-Throughput Expression Data
or
Untitled Document detailed view CG16989-RA Rbf-RA CG13359-RA
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

modENCODE Temporal Expression Data for FBgn0015799


   Styles
Linear
Logarithmic
Heatmap
   Scales
max expr for FBgn0015799
Very low expression bin max
Moderate expression bin max
High expression bin max
Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages.
[download data (TSV)]

Guide to modENCODE expression level colors
 
No expression (0 - 0)
 
Extremely low expression (1 - 10)
 
Very low expression (11 - 100)
 
Low expression (101 - 400)
 
Moderate expression (401 - 1400)
 
Moderately high expression (1401 - 4000)
 
High expression (4001 - 10000)
 
Very high expression (10001 - 100000)
 
Extremely high expression (100001 - 2000000)

Linear, scaled to maximum FBgn0015799 expression level
Developmental Stage   Expression Level
embryo 00-02hr
 
 8378
embryo 02-04hr
 
 1827
embryo 04-06hr
 
 3645
embryo 06-08hr
 
 3927
embryo 08-10hr
 
 2767
embryo 10-12hr
 
 2094
embryo 12-14hr
 
 1417
embryo 14-16hr
 
 1457
embryo 16-18hr
 
 1267
embryo 18-20hr
 
 754
embryo 20-22hr
 
 641
embryo 22-24hr
 
 604
larva L1
 
 1691
larva L2
 
 1521
larva L3 12hr old
 
 1068
larva L3 puffstage 1-2
 
 766
larva L3 puffstage 3-6
 
 1175
larva L3 puffstage 7-9
 
 1286
white prepupae new
 
 1345
white prepupae 12hr
 
 1636
white prepupae 24hr
 
 1755
pupae 2d postWPP
 
 1003
pupae 3d postWPP
 
 642
pupae 4d postWPP
 
 633
adult male 01day
 
 798
adult male 05day
 
 1005
adult male 30day
 
 976
adult female 01day
 
 2626
adult female 05day
 
 4503
adult female 30day
 
 4809
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
Linear, scaled to Very low expression
Developmental Stage   Expression Level
embryo 00-02hr
 (8378)
embryo 02-04hr
 (1827)
embryo 04-06hr
 (3645)
embryo 06-08hr
 (3927)
embryo 08-10hr
 (2767)
embryo 10-12hr
 (2094)
embryo 12-14hr
 (1417)
embryo 14-16hr
 (1457)
embryo 16-18hr
 (1267)
embryo 18-20hr
 (754)
embryo 20-22hr
 (641)
embryo 22-24hr
 (604)
larva L1
 (1691)
larva L2
 (1521)
larva L3 12hr old
 (1068)
larva L3 puffstage 1-2
 (766)
larva L3 puffstage 3-6
 (1175)
larva L3 puffstage 7-9
 (1286)
white prepupae new
 (1345)
white prepupae 12hr
 (1636)
white prepupae 24hr
 (1755)
pupae 2d postWPP
 (1003)
pupae 3d postWPP
 (642)
pupae 4d postWPP
 (633)
adult male 01day
 (798)
adult male 05day
 (1005)
adult male 30day
 (976)
adult female 01day
 (2626)
adult female 05day
 (4503)
adult female 30day
 (4809)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
Linear, scaled to Moderate expression
Developmental Stage   Expression Level
embryo 00-02hr
 (8378)
embryo 02-04hr
 (1827)
embryo 04-06hr
 (3645)
embryo 06-08hr
 (3927)
embryo 08-10hr
 (2767)
embryo 10-12hr
 (2094)
embryo 12-14hr
 1417
embryo 14-16hr
 1457
embryo 16-18hr
 
 1267
embryo 18-20hr
 
 754
embryo 20-22hr
 
 641
embryo 22-24hr
 
 604
larva L1
 (1691)
larva L2
 (1521)
larva L3 12hr old
 
 1068
larva L3 puffstage 1-2
 
 766
larva L3 puffstage 3-6
 
 1175
larva L3 puffstage 7-9
 
 1286
white prepupae new
 
 1345
white prepupae 12hr
 (1636)
white prepupae 24hr
 (1755)
pupae 2d postWPP
 
 1003
pupae 3d postWPP
 
 642
pupae 4d postWPP
 
 633
adult male 01day
 
 798
adult male 05day
 
 1005
adult male 30day
 
 976
adult female 01day
 (2626)
adult female 05day
 (4503)
adult female 30day
 (4809)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
Linear, scaled to High expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 8378
embryo 02-04hr
 
 1827
embryo 04-06hr
 
 3645
embryo 06-08hr
 
 3927
embryo 08-10hr
 
 2767
embryo 10-12hr
 
 2094
embryo 12-14hr
 
 1417
embryo 14-16hr
 
 1457
embryo 16-18hr
 
 1267
embryo 18-20hr
 
 754
embryo 20-22hr
 
 641
embryo 22-24hr
 
 604
larva L1
 
 1691
larva L2
 
 1521
larva L3 12hr old
 
 1068
larva L3 puffstage 1-2
 
 766
larva L3 puffstage 3-6
 
 1175
larva L3 puffstage 7-9
 
 1286
white prepupae new
 
 1345
white prepupae 12hr
 
 1636
white prepupae 24hr
 
 1755
pupae 2d postWPP
 
 1003
pupae 3d postWPP
 
 642
pupae 4d postWPP
 
 633
adult male 01day
 
 798
adult male 05day
 
 1005
adult male 30day
 
 976
adult female 01day
 
 2626
adult female 05day
 
 4503
adult female 30day
 
 4809
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Extremely high expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 8378
embryo 02-04hr
 
 1827
embryo 04-06hr
 
 3645
embryo 06-08hr
 
 3927
embryo 08-10hr
 
 2767
embryo 10-12hr
 
 2094
embryo 12-14hr
 
 1417
embryo 14-16hr
 
 1457
embryo 16-18hr
 
 1267
embryo 18-20hr
 
 754
embryo 20-22hr
 
 641
embryo 22-24hr
 
 604
larva L1
 
 1691
larva L2
 
 1521
larva L3 12hr old
 
 1068
larva L3 puffstage 1-2
 
 766
larva L3 puffstage 3-6
 
 1175
larva L3 puffstage 7-9
 
 1286
white prepupae new
 
 1345
white prepupae 12hr
 
 1636
white prepupae 24hr
 
 1755
pupae 2d postWPP
 
 1003
pupae 3d postWPP
 
 642
pupae 4d postWPP
 
 633
adult male 01day
 
 798
adult male 05day
 
 1005
adult male 30day
 
 976
adult female 01day
 
 2626
adult female 05day
 
 4503
adult female 30day
 
 4809
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
log, scaled to maximum FBgn0015799 expression level
Developmental Stage   Expression Level
embryo 00-02hr
 
 8378
embryo 02-04hr
 
 1827
embryo 04-06hr
 
 3645
embryo 06-08hr
 
 3927
embryo 08-10hr
 
 2767
embryo 10-12hr
 
 2094
embryo 12-14hr
 
 1417
embryo 14-16hr
 
 1457
embryo 16-18hr
 
 1267
embryo 18-20hr
 
 754
embryo 20-22hr
 
 641
embryo 22-24hr
 
 604
larva L1
 
 1691
larva L2
 
 1521
larva L3 12hr old
 
 1068
larva L3 puffstage 1-2
 
 766
larva L3 puffstage 3-6
 
 1175
larva L3 puffstage 7-9
 
 1286
white prepupae new
 
 1345
white prepupae 12hr
 
 1636
white prepupae 24hr
 
 1755
pupae 2d postWPP
 
 1003
pupae 3d postWPP
 
 642
pupae 4d postWPP
 
 633
adult male 01day
 
 798
adult male 05day
 
 1005
adult male 30day
 
 976
adult female 01day
 
 2626
adult female 05day
 
 4503
adult female 30day
 
 4809
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Very low expression
Developmental Stage   Expression Level
embryo 00-02hr
 (8378)
embryo 02-04hr
 (1827)
embryo 04-06hr
 (3645)
embryo 06-08hr
 (3927)
embryo 08-10hr
 (2767)
embryo 10-12hr
 (2094)
embryo 12-14hr
 (1417)
embryo 14-16hr
 (1457)
embryo 16-18hr
 (1267)
embryo 18-20hr
 (754)
embryo 20-22hr
 (641)
embryo 22-24hr
 (604)
larva L1
 (1691)
larva L2
 (1521)
larva L3 12hr old
 (1068)
larva L3 puffstage 1-2
 (766)
larva L3 puffstage 3-6
 (1175)
larva L3 puffstage 7-9
 (1286)
white prepupae new
 (1345)
white prepupae 12hr
 (1636)
white prepupae 24hr
 (1755)
pupae 2d postWPP
 (1003)
pupae 3d postWPP
 (642)
pupae 4d postWPP
 (633)
adult male 01day
 (798)
adult male 05day
 (1005)
adult male 30day
 (976)
adult female 01day
 (2626)
adult female 05day
 (4503)
adult female 30day
 (4809)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
log, scaled to Moderate expression
Developmental Stage   Expression Level
embryo 00-02hr
 (8378)
embryo 02-04hr
 1827
embryo 04-06hr
 (3645)
embryo 06-08hr
 (3927)
embryo 08-10hr
 (2767)
embryo 10-12hr
 2094
embryo 12-14hr
 1417
embryo 14-16hr
 1457
embryo 16-18hr
 
 1267
embryo 18-20hr
 
 754
embryo 20-22hr
 
 641
embryo 22-24hr
 
 604
larva L1
 1691
larva L2
 1521
larva L3 12hr old
 
 1068
larva L3 puffstage 1-2
 
 766
larva L3 puffstage 3-6
 
 1175
larva L3 puffstage 7-9
 
 1286
white prepupae new
 
 1345
white prepupae 12hr
 1636
white prepupae 24hr
 1755
pupae 2d postWPP
 
 1003
pupae 3d postWPP
 
 642
pupae 4d postWPP
 
 633
adult male 01day
 
 798
adult male 05day
 
 1005
adult male 30day
 
 976
adult female 01day
 (2626)
adult female 05day
 (4503)
adult female 30day
 (4809)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
log, scaled to High expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 8378
embryo 02-04hr
 
 1827
embryo 04-06hr
 
 3645
embryo 06-08hr
 
 3927
embryo 08-10hr
 
 2767
embryo 10-12hr
 
 2094
embryo 12-14hr
 
 1417
embryo 14-16hr
 
 1457
embryo 16-18hr
 
 1267
embryo 18-20hr
 
 754
embryo 20-22hr
 
 641
embryo 22-24hr
 
 604
larva L1
 
 1691
larva L2
 
 1521
larva L3 12hr old
 
 1068
larva L3 puffstage 1-2
 
 766
larva L3 puffstage 3-6
 
 1175
larva L3 puffstage 7-9
 
 1286
white prepupae new
 
 1345
white prepupae 12hr
 
 1636
white prepupae 24hr
 
 1755
pupae 2d postWPP
 
 1003
pupae 3d postWPP
 
 642
pupae 4d postWPP
 
 633
adult male 01day
 
 798
adult male 05day
 
 1005
adult male 30day
 
 976
adult female 01day
 
 2626
adult female 05day
 
 4503
adult female 30day
 
 4809
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Extremely high expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 8378
embryo 02-04hr
 
 1827
embryo 04-06hr
 
 3645
embryo 06-08hr
 
 3927
embryo 08-10hr
 
 2767
embryo 10-12hr
 
 2094
embryo 12-14hr
 
 1417
embryo 14-16hr
 
 1457
embryo 16-18hr
 
 1267
embryo 18-20hr
 
 754
embryo 20-22hr
 
 641
embryo 22-24hr
 
 604
larva L1
 
 1691
larva L2
 
 1521
larva L3 12hr old
 
 1068
larva L3 puffstage 1-2
 
 766
larva L3 puffstage 3-6
 
 1175
larva L3 puffstage 7-9
 
 1286
white prepupae new
 
 1345
white prepupae 12hr
 
 1636
white prepupae 24hr
 
 1755
pupae 2d postWPP
 
 1003
pupae 3d postWPP
 
 642
pupae 4d postWPP
 
 633
adult male 01day
 
 798
adult male 05day
 
 1005
adult male 30day
 
 976
adult female 01day
 
 2626
adult female 05day
 
 4503
adult female 30day
 
 4809
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
Heatmap
Developmental Stage   Expression Level
embryo 00-02hr
 
 
embryo 02-04hr
 
 
embryo 04-06hr
 
 
embryo 06-08hr
 
 
embryo 08-10hr
 
 
embryo 10-12hr
 
 
embryo 12-14hr
 
 
embryo 14-16hr
 
 
embryo 16-18hr
 
 
embryo 18-20hr
 
 
embryo 20-22hr
 
 
embryo 22-24hr
 
 
larva L1
 
 
larva L2
 
 
larva L3 12hr old
 
 
larva L3 puffstage 1-2
 
 
larva L3 puffstage 3-6
 
 
larva L3 puffstage 7-9
 
 
white prepupae new
 
 
white prepupae 12hr
 
 
white prepupae 24hr
 
 
pupae 2d postWPP
 
 
pupae 3d postWPP
 
 
pupae 4d postWPP
 
 
adult male 01day
 
 
adult male 05day
 
 
adult male 30day
 
 
adult female 01day
 
 
adult female 05day
 
 
adult female 30day
 
 

FlyAtlas Anatomical Expression Data for FBgn0015799


   Styles
Linear
Logarithmic
Heatmap
Back-to-back
   Scales
max expr for FBgn0015799
Moderate expression bin max
High level expression bin max
Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval salivary gland, adult ovary.
[download data (TSV)]

Guide to FlyAtlas expression level colors
 
No expression (0 - 9.999)
 
Low expression (10 - 99.999)
 
Moderate expression (100 - 499.999)
 
High level expression (500 - 999.999)
 
Very high expression (1000 - 25000)

Linear, scaled to maximum FBgn0015799 expression level
Tissue   Expression Level
Larval Central Nervous System
 
 158.475
Larval Midgut
 
 57
Larval Hindgut
 
 78.6
Larval Malpighian Tubules
 
 28.8
Larval Fat Body no informative data
Larval Salivary Gland
 
 136.1
Larval Trachea
 
 91.575
Larval Carcass
 
 82.625
Adult Head
 
 45.1
Adult Eye
 
 35.5
Adult Brain
 
 107.2
Adult Thoracic-Abdominal Ganglion
 
 61.9
Adult Crop no informative data
Adult Midgut
 
 46.8
Adult Hindgut
 
 40.4
Adult Malpighian Tubules
 
 51.4
Adult Fat Body
 
 41.3
Adult Salivary Gland
 
 80.8
Adult Heart
 
 30.075
Adult VirginFemale Spermatheca no informative data
Adult InseminatedFemale Spermatheca
 
 37.9
Adult Ovary
 
 381.2
Adult Testis
 
 83.2
Adult Male Accessory Gland
 
 45.2
Adult Carcass no informative data
Expression Level Scale
 None 
 Low 
 Moderate 
Linear, scaled to Moderate expression
Tissue   Expression Level
Larval Central Nervous System
 
 158.475
Larval Midgut
 
 57
Larval Hindgut
 
 78.6
Larval Malpighian Tubules
 
 28.8
Larval Fat Body no informative data
Larval Salivary Gland
 
 136.1
Larval Trachea
 
 91.575
Larval Carcass
 
 82.625
Adult Head
 
 45.1
Adult Eye
 
 35.5
Adult Brain
 
 107.2
Adult Thoracic-Abdominal Ganglion
 
 61.9
Adult Crop no informative data
Adult Midgut
 
 46.8
Adult Hindgut
 
 40.4
Adult Malpighian Tubules
 
 51.4
Adult Fat Body
 
 41.3
Adult Salivary Gland
 
 80.8
Adult Heart
 
 30.075
Adult VirginFemale Spermatheca no informative data
Adult InseminatedFemale Spermatheca
 
 37.9
Adult Ovary
 
 381.2
Adult Testis
 
 83.2
Adult Male Accessory Gland
 
 45.2
Adult Carcass no informative data
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
Linear, scaled to High level expression
Tissue   Expression Level
Larval Central Nervous System
 
 158.475
Larval Midgut
 
 57
Larval Hindgut
 
 78.6
Larval Malpighian Tubules
 
 28.8
Larval Fat Body no informative data
Larval Salivary Gland
 
 136.1
Larval Trachea
 
 91.575
Larval Carcass
 
 82.625
Adult Head
 
 45.1
Adult Eye
 
 35.5
Adult Brain
 
 107.2
Adult Thoracic-Abdominal Ganglion
 
 61.9
Adult Crop no informative data
Adult Midgut
 
 46.8
Adult Hindgut
 
 40.4
Adult Malpighian Tubules
 
 51.4
Adult Fat Body
 
 41.3
Adult Salivary Gland
 
 80.8
Adult Heart
 
 30.075
Adult VirginFemale Spermatheca no informative data
Adult InseminatedFemale Spermatheca
 
 37.9
Adult Ovary
 
 381.2
Adult Testis
 
 83.2
Adult Male Accessory Gland
 
 45.2
Adult Carcass no informative data
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
Linear, scaled to Very high expression
Tissue   Expression Level
Larval Central Nervous System
 
 158.475
Larval Midgut
 
 57
Larval Hindgut
 
 78.6
Larval Malpighian Tubules
 
 28.8
Larval Fat Body no informative data
Larval Salivary Gland
 
 136.1
Larval Trachea
 
 91.575
Larval Carcass
 
 82.625
Adult Head
 
 45.1
Adult Eye
 
 35.5
Adult Brain
 
 107.2
Adult Thoracic-Abdominal Ganglion
 
 61.9
Adult Crop no informative data
Adult Midgut
 
 46.8
Adult Hindgut
 
 40.4
Adult Malpighian Tubules
 
 51.4
Adult Fat Body
 
 41.3
Adult Salivary Gland
 
 80.8
Adult Heart
 
 30.075
Adult VirginFemale Spermatheca no informative data
Adult InseminatedFemale Spermatheca
 
 37.9
Adult Ovary
 
 381.2
Adult Testis
 
 83.2
Adult Male Accessory Gland
 
 45.2
Adult Carcass no informative data
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
log, scaled to maximum FBgn0015799 expression level
Tissue   Expression Level
Larval Central Nervous System
 
 158.475
Larval Midgut
 
 57
Larval Hindgut
 
 78.6
Larval Malpighian Tubules
 
 28.8
Larval Fat Body no informative data
Larval Salivary Gland
 
 136.1
Larval Trachea
 
 91.575
Larval Carcass
 
 82.625
Adult Head
 
 45.1
Adult Eye
 
 35.5
Adult Brain
 
 107.2
Adult Thoracic-Abdominal Ganglion
 
 61.9
Adult Crop no informative data
Adult Midgut
 
 46.8
Adult Hindgut
 
 40.4
Adult Malpighian Tubules
 
 51.4
Adult Fat Body
 
 41.3
Adult Salivary Gland
 
 80.8
Adult Heart
 
 30.075
Adult VirginFemale Spermatheca no informative data
Adult InseminatedFemale Spermatheca
 
 37.9
Adult Ovary
 
 381.2
Adult Testis
 
 83.2
Adult Male Accessory Gland
 
 45.2
Adult Carcass no informative data
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
log, scaled to Moderate expression
Tissue   Expression Level
Larval Central Nervous System
 
 158.475
Larval Midgut
 
 57
Larval Hindgut
 
 78.6
Larval Malpighian Tubules
 
 28.8
Larval Fat Body no informative data
Larval Salivary Gland
 
 136.1
Larval Trachea
 
 91.575
Larval Carcass
 
 82.625
Adult Head
 
 45.1
Adult Eye
 
 35.5
Adult Brain
 
 107.2
Adult Thoracic-Abdominal Ganglion
 
 61.9
Adult Crop no informative data
Adult Midgut
 
 46.8
Adult Hindgut
 
 40.4
Adult Malpighian Tubules
 
 51.4
Adult Fat Body
 
 41.3
Adult Salivary Gland
 
 80.8
Adult Heart
 
 30.075
Adult VirginFemale Spermatheca no informative data
Adult InseminatedFemale Spermatheca
 
 37.9
Adult Ovary
 
 381.2
Adult Testis
 
 83.2
Adult Male Accessory Gland
 
 45.2
Adult Carcass no informative data
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
log, scaled to High level expression
Tissue   Expression Level
Larval Central Nervous System
 
 158.475
Larval Midgut
 
 57
Larval Hindgut
 
 78.6
Larval Malpighian Tubules
 
 28.8
Larval Fat Body no informative data
Larval Salivary Gland
 
 136.1
Larval Trachea
 
 91.575
Larval Carcass
 
 82.625
Adult Head
 
 45.1
Adult Eye
 
 35.5
Adult Brain
 
 107.2
Adult Thoracic-Abdominal Ganglion
 
 61.9
Adult Crop no informative data
Adult Midgut
 
 46.8
Adult Hindgut
 
 40.4
Adult Malpighian Tubules
 
 51.4
Adult Fat Body
 
 41.3
Adult Salivary Gland
 
 80.8
Adult Heart
 
 30.075
Adult VirginFemale Spermatheca no informative data
Adult InseminatedFemale Spermatheca
 
 37.9
Adult Ovary
 
 381.2
Adult Testis
 
 83.2
Adult Male Accessory Gland
 
 45.2
Adult Carcass no informative data
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
log, scaled to Very high expression
Tissue   Expression Level
Larval Central Nervous System
 
 158.475
Larval Midgut
 
 57
Larval Hindgut
 
 78.6
Larval Malpighian Tubules
 
 28.8
Larval Fat Body no informative data
Larval Salivary Gland
 
 136.1
Larval Trachea
 
 91.575
Larval Carcass
 
 82.625
Adult Head
 
 45.1
Adult Eye
 
 35.5
Adult Brain
 
 107.2
Adult Thoracic-Abdominal Ganglion
 
 61.9
Adult Crop no informative data
Adult Midgut
 
 46.8
Adult Hindgut
 
 40.4
Adult Malpighian Tubules
 
 51.4
Adult Fat Body
 
 41.3
Adult Salivary Gland
 
 80.8
Adult Heart
 
 30.075
Adult VirginFemale Spermatheca no informative data
Adult InseminatedFemale Spermatheca
 
 37.9
Adult Ovary
 
 381.2
Adult Testis
 
 83.2
Adult Male Accessory Gland
 
 45.2
Adult Carcass no informative data
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
Heatmap
Tissue   Expression Level
Larval Central Nervous System
 
 
Larval Midgut
 
 
Larval Hindgut
 
 
Larval Malpighian Tubules
 
 
Larval Fat Body no informative data
Larval Salivary Gland
 
 
Larval Trachea
 
 
Larval Carcass
 
 
Adult Head
 
 
Adult Eye
 
 
Adult Brain
 
 
Adult Thoracic-Abdominal Ganglion
 
 
Adult Crop no informative data
Adult Midgut
 
 
Adult Hindgut
 
 
Adult Malpighian Tubules
 
 
Adult Fat Body
 
 
Adult Salivary Gland
 
 
Adult Heart
 
 
Adult VirginFemale Spermatheca no informative data
Adult InseminatedFemale Spermatheca
 
 
Adult Ovary
 
 
Adult Testis
 
 
Adult Male Accessory Gland
 
 
Adult Carcass no informative data

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level Tissue Adult Expression Level
 
NA 
Head
 
 45.1
 
NA 
Eye
 
 35.5
 
NA 
Brain
 
 107.2
 
158.475 
Central Nervous System
 
 NA
 
NA 
Thoracic-Abdominal Ganglion
 
 61.9
 
NA 
Crop
 
 no informative data
 
57 
Midgut
 
 46.8
 
78.6 
Hindgut
 
 40.4
 
28.8 
Malpighian Tubules
 
 51.4
 
no informative data 
Fat Body
 
 41.3
 
136.1 
Salivary Gland
 
 80.8
 
NA 
Heart
 
 30.075
 
91.575 
Trachea
 
 NA
 
NA 
VirginFemale Spermatheca
 
 no informative data
 
NA 
InseminatedFemale Spermatheca
 
 37.9
 
NA 
Ovary
 
 381.2
 
NA 
Testis
 
 83.2
 
NA 
Male Accessory Gland
 
 45.2
 
82.625 
Carcass
 
 no informative data

modENCODE Temporal Expression Data (Graveley et al., 2011)
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
hide Expression Clusters
A cluster of genes with similar mRNA expression dynamics across development.
hide External Data & Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyExpress - Embryonic expression images (BDGP data)
hide Alleles & Phenotypes
hide Summary of Allele Phenotypes
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
embryonic epidermis & S phase
embryonic epidermis & S phase | germ-line clone
follicle cell & cell cycle (with Rbf11)
follicle cell & cell cycle (with Rbf120a)
S phase | ectopic & eye disc | posterior (with Rbf11)
S phase | ectopic & eye disc | posterior (with Rbf120a)
hide Classical Alleles ( 18 )
For All Classical Alleles Show

Allele of RbfClassMutagenStocksKnown lesion
Rbf14amorphic allele - genetic evidence1 Yes
Rbfcas-211 Yes
Rbfd00614
1 --
RbfEY072091 --
RbfGS5173
1 --
Rbfsls-151 Yes
Rbf110 Yes
Rbf120-3-3
0 --
Rbf120a0 Yes
Rbf15a0 Yes
Rbf15aΔ0 Yes
Rbf160 Yes
Rbf38a0 Yes
RbfCAS-21
0 --
RbfGG01588
0 --
RbfSLS-15
0 Yes
Rbfunspecified
0 --
RbfΔ14loss of function allele
0 --
hide Alleles Carried on Transgenic Constructs ( 40 )
For All Alleles Carried on Transgenic Constructs Show

Allele of RbfClassMutagenStocksKnown lesion
Rbft.Exel2 Yes
RbfGD44841 Yes
Rbf1-717.Scer\UAS0 Yes
Rbf1-845.Scer\UAS0 Yes
Rbf10.cXa0 Yes
Rbf10.hs0 Yes
Rbf10.Scer\UAS0 Yes
Rbf16.Scer\UAS0 Yes
Rbf223.cXa0 Yes
Rbf223.Scer\UAS0 Yes
Rbf280.cXa0 Yes
Rbf280.GMR0 Yes
Rbf280.hs0 Yes
Rbf280.Scer\UAS0 Yes
Rbf30.cXa0 Yes
Rbf30.hs0 Yes
Rbf30.Scer\UAS0 Yes
Rbf555L.hs0 Yes
Rbf555L.Scer\UAS0 Yes
Rbf596W.hs0 Yes
Rbf596W.Scer\UAS0 Yes
Rbf6KA.Scer\UAS0 Yes
RbfAct5C.PD0 Yes
RbfcFa0 Yes
RbfdsRNA.cFa0 Yes
RbfdsRNA.cKa0 Yes
RbfdsRNA.cLa0 Yes
RbfGMR.PD0 Yes
Rbfhs.PD0 Yes
Rbfie1.T:Ivir\HA10 Yes
RbfK754A.Scer\UAS0 Yes
RbfK774A.Scer\UAS0 Yes
RbfK774R.Scer\UAS0 Yes
RbfM4.cXa0 Yes
RbfN.Scer\UAS.P\T.T:Disc\RFP-mCherry,T:SV5\V50 Yes
RbfScer\UAS.cDa0 Yes
RbfT:Zzzz\FLAG0 Yes
RbfWT.T:Zzzz\FLAG0 Yes
RbfΔ728-786.Scer\UAS0 Yes
RbfΔIE.T:Zzzz\FLAG0 Yes
hide Aneuploid Aberrations
Disrupted in
Not disrupted in
Duplicated in
hide Transgenic Constructs & Insertions
Transgenic Constructs
Type of construct
Name
Expression data
Insertions
Type of insertions
Name
Expression data
hide Gene Ontology: Function, Process & Cellular Component ( 23 unique terms )
hide Terms Based on Experimental Evidence ( 19 terms )
Molecular Function
CV term
References
inferred from physical interaction with Snr1
inferred from physical interaction with Dp
inferred from physical interaction with Dp AND inferred from physical interaction with E2f
inferred from physical interaction with E2f2
inferred from physical interaction with E2f
Biological Process
CV term
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from direct assay
Cellular Component
CV term
References
inferred from direct assay
inferred from direct assay
hide Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term
References
non-traceable author statement
Biological Process
CV term
References
inferred from sequence or structural similarity with human RBL1
Cellular Component
CV term
References
non-traceable author statement
traceable author statement
hide Sequence Ontology: Class of Gene
hide Interactions & Pathways
hide Summary of Physical Interactions
Protein-protein
Interacting group
Assay
References
hide Summary of Genetic Interactions
Interacts with
Please look at the allele data for full details of the genetic interactions
Rbf allele
Gene
References
hide External Data
Linkouts
BioGRID - A database of protein and genetic interactions
DPiM - DPiM, Drosophila Protein interaction Map
DroID - A comprehensive database of gene and protein interactions.
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
hide Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs
Linkouts
InParanoid A subset of ortholog calls from InParanoid.
OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs.
hide Stocks & Reagents
hide Stocks Listed in FlyBase ( 9 )
Bloomington
Harvard
Kyoto
VDRC
hide Genomic Clones ( 1 )
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
hide cDNA Clones ( 219 )
Please Note
This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
hide RNAi & Array Information
Linkouts
DRSC - Results from RNAi screens.
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
hide Antibody Information
hide Other Information
hide Discoverer
hide Etymology
hide Identification
hide Relationship to Other Genes
Source for database identity of
Source for identity of: Rbf CG7413
Source for database merge of
Additional comments
hide Other Comments
gig and Rbf synergistically induce oxidative stress via increased protein synthesis, inhibited de novo lipid synthesis, and decreased reactive oxygen species enzyme induction.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
E2f2 as part of the E2f-Rb complexes has a role in the down regulation of CycE during the gap phase of endocycling cells in normal development.
Rbf is required at multiple stages of development. Most, if not all, of the function of Rbf during development is mediated through E2f.
Rbf is dispensable for early cell cycles in the embryo, but plays an essential role in the introduction of G1 control during development.
Overexpression of dap during eye development interferes with cell cycle progression and interacts genetically with Rbf and CycE.
Identification: Yeast two hybrid screen for proteins that interact with E2f.
Rbf plays a critical role in the regulation of cell proliferation.
hide External Crossreferences & Linkouts
Sequence Crossreferences
RefSeq (Transcripts)
RefSeq (Proteins)
Entrez Gene - A searchable database of RefSeq genes.
Other Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
Linkouts
BioGRID - A database of protein and genetic interactions
DPiM - DPiM, Drosophila Protein interaction Map
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results from RNAi screens.
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
InParanoid A subset of ortholog calls from InParanoid.
Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
modMine - Data generated by the modENCODE project.
OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs.
hide Synonyms & Secondary IDs ( 23 )
Reported As
Symbol Synonym
Name Synonym
retinoblastoma
Retinoblastoma
retinoblastoma factor
retinoblastoma-family homolog
retinoblastoma-family protein
retinoblastoma family protein 1
Secondary FlyBase IDs
hide References ( 199 )
Generate a list of
List References by type
hide Recent research papers ( 15 )
Kondo and Perrimon, 2011, Sci. Signal. 4(154): rs1
A Genome-Wide RNAi Screen Identifies Core Components of the G2-M DNA Damage Checkpoint. [FBrf0212700]
Nicolay et al., 2011, Genes Dev. 25(4): 323--335
Cooperation between dE2F1 and Yki/Sd defines a distinct transcriptional program necessary to bypass cell cycle exit. [FBrf0214348]
Sukhanova et al., 2011, Dev. Biol. 359(2): 190--198
RBF and Rno promote photoreceptor differentiation onset through modulating EGFR signaling in the Drosophila developing eye. [FBrf0216493]
Acharya et al., 2010, Mol. Biol. Cell 21(22): 3890--3901
Paradoxical Instability-Activity Relationship Defines a Novel Regulatory Pathway for Retinoblastoma Proteins. [FBrf0212298]
Buttitta et al., 2010, J. Cell Biol. 189(6): 981--996
A robust cell cycle control mechanism limits E2F-induced proliferation of terminally differentiated cells in vivo. [FBrf0211029]
Gehrke et al., 2010, Nature 466(7306): 637--641
Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression. [FBrf0211387]
Gou et al., 2010, PLoS ONE 5(5): e10581
SETDB1 Is Involved in Postembryonic DNA Methylation and Gene Silencing in Drosophila. [FBrf0210815]
Herranz et al., 2010, EMBO J. 29(10): 1688--1698
The miRNA machinery targets Mei-P26 and regulates Myc protein levels in the Drosophila wing. [FBrf0210816]
Herz et al., 2010, Mol. Cell. Biol. 30(10): 2485--2497
The H3K27me3 demethylase dUTX is a suppressor of notch- and Rb-dependent tumors in Drosophila. [FBrf0210661]
Hsieh et al., 2010, PLoS Genet. 6(8):
Tuberous Sclerosis Complex 1 Regulates dE2F1 Expression during Development and Cooperates with RBF1 to Control Proliferation and Survival. [FBrf0211700]
Lee et al., 2010, Mol. Cell. Biol. 30(10): 2563--2577
Drosophila RB proteins repress differentiation-specific genes via two different mechanisms. [FBrf0210656]
Li et al., 2010, Cancer Cell 17(5): 469--480
Specific Killing of Rb Mutant Cancer Cells by Inactivating TSC2. [FBrf0210758]
Manning et al., 2010, Genes Dev. 24(13): 1364--1376
Loss of pRB causes centromere dysfunction and chromosomal instability. [FBrf0214901]
Nedelsky et al., 2010, Neuron 67(6): 936--952
Native functions of the androgen receptor are essential to pathogenesis in a Drosophila model of spinobulbar muscular atrophy. [FBrf0211903]
Nicolay et al., 2010, PLoS Genet. 6(4): e1000918
Combined inactivation of pRB and hippo pathways induces dedifferentiation in the Drosophila retina. [FBrf0210644]
hide Recent reviews (0)
All reviews listed in FlyBase were published before 2010