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General Information
Symbol
Dmel\HDAC1
Species
D. melanogaster
Name
Histone deacetylase 1
Annotation Symbol
CG7471
Feature Type
FlyBase ID
FBgn0015805
Gene Model Status
Stock Availability
Enzyme Name (EC)
Histone deacetylase (3.5.1.98)
Gene Snapshot
In progress.Contributions welcome.
Also Known As
Rpd3, dHDAC1, dRPD3, HDAC, l(3)04556
Key Links
Genomic Location
Cytogenetic map
Sequence location
3L:4,626,734..4,629,467 [+]
Recombination map
3-12
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Protein Family (UniProt)
Belongs to the histone deacetylase family. HD type 1 subfamily. (Q94517)
Catalytic Activity (EC)
Experimental Evidence
Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (3.5.1.98)
Predictions / Assertions
Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (3.5.1.98)
Summaries
Gene Group (FlyBase)
NUCLEOSOME REMODELING DEACETYLASE COMPLEX -
The nucleosome remodelling and deacetylase (NuRD) complex couples chromatin remodelling and histone deacetylation to mediate transcriptional repression. (Adapted from FBrf0228973 and FBrf0228920).
RPD3/HDA1 LYSINE DEACETYLASES -
The RPD3/HDA1 family are Zn2+-dependent lysine deacetylases that share a common catalytic core domain. (Adapted from FBrf0159755).
Pathway (FlyBase)
Negative Regulators of Hedgehog Signaling Pathway -
Negative regulators of hedgehog signaling down-regulation the pathway, resulting in the repression of transcription of hh-responsive genes.
Protein Function (UniProtKB)
Catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:11571273, PubMed:28245922, PubMed:12408863). Histone deacetylation may constitute a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:11571273, PubMed:8955276, PubMed:15545624, PubMed:15306652). For instance, deacetylation of histone H3 may be a prerequisite for the subsequent recruitment of the histone methyltransferase Su(var)3-9 to histones (PubMed:11571273). Involved in position-effect variegation (PEV) (PubMed:11571273). In the larval brain, part of a regulatory network including the transcriptional repressors klu, dpn and E(spl)mgamma-HLH which is required for type II neuroblast self-renewal and for maintaining erm in an inactive state in intermediate neural progenitors (INP) (PubMed:28245922).
(UniProt, Q94517)
Summary (Interactive Fly)
histone deacetylase. functioning in gene silencing - interacts with Groucho - required for starvation stress resistance - interacts with insulin signaling in Drosophila longevity extension
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\HDAC1 or the JBrowse view of Dmel\HDAC1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.46
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.56
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0073317
2124
521
Additional Transcript Data and Comments
Reported size (kB)
2.2 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0073173
58.3
521
5.51
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)
Interacts with Su(var)3-9. Component of a form of the Esc/E(z) complex present specifically during early embryogenesis which is composed of Caf1, esc, E(z), Su(z)12, Pcl and Rpd3. The Esc/E(z) complex may also associate with Pcl and Rpd3 during early embryogenesis. This complex is distinct from the PRC1 complex, which contains many other PcG proteins like Pc, Ph, Psc, Su(z)2. The 2 complexes however cooperate and interact together during the first 3 hours of development to establish PcG silencing. Interacts with the histone methyltransferase Su(var)3-9. Component of a complex that contains at least Rpd3, CoRest and Su(var)3-3/Hdm. Component of the DREAM complex at least composed of Myb, Caf1, mip40, mip120, mip130, E2f2, Dp, Rbf, Rbf2, lin-52, Rpd3 and l(3)mbt. Interacts with neuronal repressor Ttk88.
(UniProt, Q94517)
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\HDAC1 using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Gene Ontology (37 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
inferred from physical interaction with FLYBASE:mip120; FB:FBgn0033846
inferred from physical interaction with UniProtKB:Q24459
(assigned by UniProt )
inferred from physical interaction with FLYBASE:Smyd4-2; FB:FBgn0036282
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
non-traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN002239566
(assigned by GO_Central )
inferred from sequence or structural similarity with HGNC:4852
inferred from sequence or structural similarity with SGD:S000005274
Biological Process (23 terms)
Terms Based on Experimental Evidence (19 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from physical interaction with FLYBASE:esc; FB:FBgn0000588
inferred from physical interaction with FLYBASE:E(z); FB:FBgn0000629
inferred from genetic interaction with FLYBASE:Pc; FB:FBgn0003042
inferred from physical interaction with FLYBASE:Pc; FB:FBgn0003042
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:inferred from high throughput direct assayC3; FB:FBgn0025825
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from physical interaction with FLYBASE:ci; FB:FBgn0004859
inferred from expression pattern
inferred from genetic interaction with FLYBASE:ttk; FB:FBgn0003870
inferred from mutant phenotype
(assigned by UniProt )
inferred from genetic interaction with UniProtKB:M9PF84
(assigned by UniProt )
inferred from genetic interaction with UniProtKB:Q01070
(assigned by UniProt )
inferred from genetic interaction with UniProtKB:Q26263
(assigned by UniProt )
inferred from mutant phenotype
(assigned by UniProt )
Terms Based on Predictions or Assertions (7 terms)
CV Term
Evidence
References
non-traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN002239566
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN002239566
(assigned by GO_Central )
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN002239566
(assigned by GO_Central )
Cellular Component (11 terms)
Terms Based on Experimental Evidence (9 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from physical interaction with FLYBASE:Mi-2; FB:FBgn0262519
inferred from direct assay
inferred from direct assay
inferred from physical interaction with FLYBASE:Su(var)3-3; FB:FBgn0260397
inferred from physical interaction with FLYBASE:CoRest; FB:FBgn0261573
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN002239566
(assigned by GO_Central )
non-traceable author statement
non-traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN000066122
(assigned by GO_Central )
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Gcn5 transcript is localized to the apical tip of the adult testis.
Rpd3 transcripts are more abundant during development than HDAC3 transcripts.
Transcripts are observed in RNA from embryos, larvae, and adults on northern blots. An insertion 1.8kb upstream of the Rpd3 gene causes a substantial reduction in transcript levels in the eye-antennal disc.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from physical interaction with FLYBASE:Mi-2; FB:FBgn0262519
inferred from direct assay
inferred from direct assay
inferred from physical interaction with FLYBASE:Su(var)3-3; FB:FBgn0260397
inferred from physical interaction with FLYBASE:CoRest; FB:FBgn0261573
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\HDAC1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 7-8
  • Stages(s) 11-12
  • Stages(s) 13-16
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 21 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 18 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of HDAC1
Transgenic constructs containing regulatory region of HDAC1
Deletions and Duplications ( 4 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
15 of 15
Yes
Yes
13 of 15
No
Yes
4 of 15
No
No
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
15 of 15
Yes
Yes
12 of 15
No
Yes
4 of 15
No
No
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (5)
13 of 13
Yes
Yes
12 of 13
No
Yes
11 of 13
No
Yes
4 of 13
No
No
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (4)
8 of 12
Yes
Yes
7 of 12
No
Yes
2 of 12
No
No
1 of 12
No
Yes
Danio rerio (Zebrafish) (3)
9 of 15
Yes
Yes
3 of 15
No
No
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (3)
11 of 15
Yes
Yes
9 of 15
No
Yes
4 of 15
No
No
Arabidopsis thaliana (thale-cress) (6)
8 of 9
Yes
Yes
5 of 9
No
Yes
3 of 9
No
No
2 of 9
No
Yes
1 of 9
No
Yes
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (3)
13 of 15
Yes
Yes
4 of 15
No
No
2 of 15
No
Yes
Schizosaccharomyces pombe (Fission yeast) (2)
10 of 12
Yes
Yes
2 of 12
No
No
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190808 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila persimilis
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915043P )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W04HR )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X04QD )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G067J )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (2)
6 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 3 )
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Subunit Structure (UniProtKB)
    Interacts with Su(var)3-9. Component of a form of the Esc/E(z) complex present specifically during early embryogenesis which is composed of Caf1, esc, E(z), Su(z)12, Pcl and Rpd3. The Esc/E(z) complex may also associate with Pcl and Rpd3 during early embryogenesis. This complex is distinct from the PRC1 complex, which contains many other PcG proteins like Pc, Ph, Psc, Su(z)2. The 2 complexes however cooperate and interact together during the first 3 hours of development to establish PcG silencing. Interacts with the histone methyltransferase Su(var)3-9. Component of a complex that contains at least Rpd3, CoRest and Su(var)3-3/Hdm. Component of the DREAM complex at least composed of Myb, Caf1, mip40, mip120, mip130, E2f2, Dp, Rbf, Rbf2, lin-52, Rpd3 and l(3)mbt. Interacts with neuronal repressor Ttk88.
    (UniProt, Q94517 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3L
    Recombination map
    3-12
    Cytogenetic map
    Sequence location
    3L:4,626,734..4,629,467 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    64B12-64B12
    Limits computationally determined from genome sequence between P{PZ}l(3)rG166rG166 and P{PZ}sinu06524
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    64C1-64C2
    (determined by in situ hybridisation)
    64C1-64C6
    (determined by in situ hybridisation)
    64B-64C
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Left of (cM)
    Right of (cM)
    Notes
    Maps near the tip of 3L.
    Stocks and Reagents
    Stocks (19)
    Genomic Clones (25)
    cDNA Clones (185)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for identity of: HDAC1 Rpd3
    Source for database merge of
    Source for merge of: Rpd3 l(3)04556
    Source for merge of: Rpd3 Su(var)328 Su(var)326
    Source for merge of: Rpd3 l(3)64Cc
    Additional comments
    Renamed from 'Rpd3' to 'HDAC1' (a popular synonym) to be consistent with the naming convention of the other D. melanogaster HDAC genes (i.e. named after the mammalian orthologs).
    Other Comments
    DNA-protein interactions: genome-wide binding profile assayed for Rpd3 protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069).
    Gene expression is increased in response to the presence of two copies of Scer\GAL4hs.PB.
    S2 cell populations treated with dsRNA made from templates generated with primers directed against Rpd3 show inhibition of cell growth due to a G2 arrest.
    chm and Rpd3 act as antagonistic cofactors of Jra and kay proteins to modulate JNK-dependent transcription during thorax metamorphosis and JNK-induced apoptosis.
    dsRNA has been made from templates generated with primers directed against this gene. RNAi of Rpd3 results in increased arborization of ddaD and ddaE neurons, defects in muscle, defects in dendrite morphogenesis and reproducible defects in da dendrite development.
    Rpd3 may be a component of the silencing complex for chromatin modification on specific regulatory regions of the homeotic genes.
    The Rpd3 and Caf1 proteins are contained within a complex that includes also PcG proteins esc and E(z).
    Rpd3 is required for PRE-mediated silencing in vivo.
    Specific missense mutations in Rpd3 suppress the silencing of genes subject to PEV, perhaps by acting as antimorphs that poisen the deacetylase complex.
    Mutational analysis indicates that the Rpd3 histone deacetylase acts as a global transcriptional regulator.
    gro and Rpd3 appear to form a complex in vivo and interact directly via the glycine/proline rich (GP) domain.
    Rpd3 is required for gro mediated repression and has a role in early pattern formation.
    The Rpd3 histone deacetylase is required for segmentation of the Drosophila embryo.
    Loss of Rpd3 results in increased genomic silencing, which decreases the distance from heterochromatin.
    Identified during a genetic analysis designed to identify mutations in the Dhc64C gene.
    The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(whs)} P{hsFLP} chromosomes) has been used to identify the specific maternal effect phenotype for the zygotic lethal mutation.
    The presence of Rpd3 does not have any discernible effect on wzm, wzl, wzvl, wzh or wcres, this was not checked in X/0 males.
    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 67 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    KEGG Genes - Molecular building blocks of life in the genomic space.
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    modMine - A data warehouse for the modENCODE project
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DPiM - Drosophila Protein interaction map
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyMine - An integrated database for Drosophila genomics
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (40)
    Reported As
    Symbol Synonym
    E(var)3-64BC
    Rpd3
    (Guo et al., 2019, Molaei et al., 2019, Shimaji et al., 2019, Bischof et al., 2018, Ghezzi et al., 2017, Janssens et al., 2017, Maini et al., 2017, Sharma et al., 2017, Brewer-Jensen et al., 2016, Nakajima et al., 2016, Schwartz et al., 2016, Woods and Rogina, 2016, Dietz et al., 2015, Ghasemi et al., 2015, Kang et al., 2015, Kaul et al., 2015, Nikalayevich and Ohkura, 2015, Bhaskar et al., 2014, Alfieri et al., 2013, Debruhl et al., 2013, Fitzsimons et al., 2013, Moshkin et al., 2013, Puram and Bonni, 2013, Ranjini and Ramachandra, 2013, Rohrbaugh et al., 2013, Silver-Morse and Li, 2013, Zhang et al., 2013, Eleftherianos and Castillo, 2012, Ito et al., 2012, Ito et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Nakayama et al., 2012, Rincon-Arano et al., 2012, Williams et al., 2012, Anderson et al., 2011, Burgio et al., 2011, Farkaš et al., 2011, Fitzsimons and Scott, 2011, Friedman et al., 2011, Guan et al., 2011, Joyce et al., 2011, Kim et al., 2011, Kirilly et al., 2011, Klusza and Deng, 2011, Neumüller et al., 2011, Toku et al., 2011, Walrad et al., 2011, Gan et al., 2010, Huang et al., 2010, Kong et al., 2010, Kong et al., 2010, Lorbeck et al., 2010, Mourikis et al., 2010, Swaminathan and Pile, 2010, Swaminathan et al., 2010, Tea et al., 2010, Walrad et al., 2010, Winkler et al., 2010, Zhang et al., 2010, Ayroles et al., 2009, Chen et al., 2009, Lee et al., 2009, Nie et al., 2009, Suzuki et al., 2009, Bajpe et al., 2008, Biryukova and Heitzler, 2008, Branco et al., 2008, Burgio et al., 2008, Cao et al., 2008, Chen et al., 2008, Chihara et al., 2008, González et al., 2008, Liu and Lehmann, 2008, Martinez and Arnosti, 2008, McElroy et al., 2008, Nisha et al., 2008, Pallos et al., 2008, Schmidt et al., 2008, Wang et al., 2008, Zhao et al., 2008, Buszczak et al., 2007, Chihara et al., 2007, Latouche et al., 2007, Tsai and Wang, 2007, Wang and Tsai, 2007, Xing et al., 2007, Holmes et al., 2006, Longo and Kennedy, 2006, Moorman et al., 2006, Moorman et al., 2006, Morozova et al., 2006, Parrish et al., 2006, Payankaulam et al., 2006, Shi et al., 2006, Shirangi et al., 2006, Cho et al., 2005, Harbison et al., 2005, Kohzaki and Murakami, 2005, Machida et al., 2005, Dallman et al., 2004, Wang and Brock, 2003, Czermin et al., 2002, Gim et al., 2001)
    Su(var)3-26
    Name Synonyms
    Histone Deacetylase 1
    Histone Deacetylase 1 (HDAC1)
    Histone Deacetylase-1
    Histone deacetylase 1
    Suppressor of variegation 326
    histone deacetylase
    histone deacetylase 1
    histone deacetylase RPD3
    reduced potassium dependency 3
    Secondary FlyBase IDs
    • FBgn0003632
    • FBgn0003634
    • FBgn0010843
    • FBgn0016893
    Datasets (4)
    Study focus (4)
    Experimental Role
    Project
    Project Type
    Title
    • transgene_used
    Protein profiling reveals five principal chromatin types in Drosophila cells.
    • bait_protein
    Genome-wide localization of chromosomal proteins in cell lines by ChIP-chip and ChIP-Seq.
    • bait_protein
    Genome-wide localization of chromosomal proteins in fly tissues by ChIP-chip and ChIP-Seq.
    • bait_protein
    Genome-wide localization of chromatin factors by ChIP-chip and ChIP-Seq.
    References (373)