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Gene Dmel\Rpd3

General Information
Symbol	Dmel\Rpd3	Species	D. melanogaster
Name	Rpd3	Annotation symbol	CG7471
Feature type	protein_coding_gene	FlyBase ID	FBgn0015805
Gene Model Status	Current	Stock availability	17 publicly available
Also Known As	HDAC1, dRPD3, dHDAC1, HDAC, l(3)04556, Su(var)326
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	64B12-64B12	Sequence location	3L:4,626,717..4,629,467 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Rpd3 is referred to in FlyBase by the symbol Dmel\Rpd3 (CG7471, FBgn0015805). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; histone deacetylase activity; transcription corepressor activity. There is experimental evidence for 15 unique biological process terms, many of which group under: biological regulation; cellular component organization or biogenesis; negative regulation of cellular biosynthetic process; gene silencing; negative regulation of biosynthetic process; neuron differentiation; cellular respiration; embryonic pattern specification; determination of adult lifespan; catabolic process. 36 alleles are reported. The phenotypes of these alleles are annotated with: wing disc; macrochaeta; sex comb; mesothoracic tergum; alula; wing; ommatidium. It has one annotated transcript and one annotated polypeptide. Protein features are: Histone deacetylase; Histone deacetylase domain; Histone deacetylase superfamily. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system, adult crop, larval/adult hindgut, larval/adult Malpighian tubules, larval/adult salivary gland, larval trachea, adult ovary, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1633700_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Rpd3. Gene sequence location is 3L:4626717..4629467.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593
FB2012_01	References Kirilly et al., 2011, Neuron 72(1): 86--100 Sequence features BKN21664 HFA08696 Controlled Vocabulary Terms negative regulation of transcription from RNA polymerase II promoter transcriptional repressor complex
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 64B12-64B12   Limits computationally determined from genome sequence between P{PZ}l(3)rG166rG166 and P{PZ}sinu06524
Experimentally Determined Cytological Location
Cytogenetic map Notes References 64B-64C     (Spierer, 1996.11.6) 64C7-64C8     (Mottus, 1998.8.24) 64C1-64C6     (Johnson, 1997.9.26) 64C1-64C2   (determined by in situ hybridisation)   (Spradling et al., 1999) 64C1-64C6   (determined by in situ hybridisation)   (Johnson et al., 1998) 64C1-64C2   (determined by in situ hybridisation)   (Perrimon et al., 1996) 64B-64C   (determined by in situ hybridisation)   (De Rubertis et al., 1996) 64B-64C     (De Rubertis et al., 1996) 64C1-64C2     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	3- (Sinclair et al., 1983, De Rubertis et al., 1996, Gepner et al., 1996, Spierer, 1996.11.6)
Left of (cM)
Right of (cM)
Notes	Maps near the tip of 3L. (Sinclair et al., 1983)
Gene Model & Products
Please see the GBrowse view of Dmel\Rpd3 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Rpd3-RA FBtr0073317  NM_139661   2141   521
Additional Transcript Data & Comments
Reported size (kB)	2.2 (northern blot) (De Rubertis et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Rpd3-PA   FBpp0073173   58.3   521   5.51     NP_647918   AAF47924
Additional Polypeptide Data & Comments
Reported size (kDa)	521 (aa) (Mottus et al., 2000, Johnson et al., 1998) 520 (aa) (De Rubertis et al., 1996)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Histone deacetylase superfamily (IPR000286) Histone deacetylase (IPR003084) Histone deacetylase domain (IPR023801)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201209   AA201342   AA201419   AA201513   AA202373   AA202647   AA263321   AA263673   AA264310   AA264929   AA392092   AA392703   AA392801   AA392871   AA392908   AA440171   AA440619   AA440725   AA536503   AA538879   AA539365   AA539604   AA540188   AA540906   AA696898   AA735144   AA735296   AA735340   AA803742   AA816260   AA816588   AA816966   AA820182   AA820333   AA941409   AA941447   AA948799   AA949427   AA949720   AA949860   AA950807   AA979264   AE014296 AAF47924   AF026949 AAC23917   AF086715 AAC61494   AI061694   AI135186   AI256888   AI257423   AI258092   AI258404   AI455114   AI455676   AI456334   AI456826   AI456926   AI511746   AI512978   AI514371   AI515016   AI516763   AI518370   AI518586   AI518725   AI518989   AI519224   AI519699   AI520028   AI520145   AI533938   AI534443   AI541962   AI542303   AI542991   AI543927   AI546527   AI546554   AQ073107   AY058487 AAL13716   BG632297   BG635506   BI163285   BI164594   BI173050   BI173540   BI214078   BI231324   BI234681   BI236270   BI242663   BI355128   BI362212   BI372475   BI375781   BI483721   BI485073   BI577870   BI579812   BI632235   BI636790   BI636898   BI637253   BI639621   CA806206   CK657697   CO177740   CO266193   CO278720   CO289682   CO311894   CO317806   CO321959   CZ469061   CZ479671   EC061175   EC066671   EC068547   EC084469   EC194429   EC213711   EC219107   EC225405   EC241365   EC241491   EC243158   EC250620   EV577168   EV583968   EV596612   FL502526   G00703   GH752843   GH753373   GH754401   GH755748   GH770597   GH774199   GH774524   GH774925   GH777350   GH781112   GH782735   GH793118   GH795526   GH801781   GH803711   GH805391   GH807574   GH812656   GH814595   GH816386   GH824146   GH825186   GH826200   GH827864   GH830112   GH835681   GH842871   GH844370   GH850109   GH850652   GH850910   GH852121   GH857790   GH857814   GH859082   GH859621   GH859872   GH860457   GH861361   GH861511   GH861618   GH863043   GH868139   GH871730   GH873101   GH878649   GH879541   GH882715   GH884168   GH887460   GH887819   GH892268   GH892699   GH899790   GH901396   GH905468   GH915489   GH916364   GH919144   GH921452   GH926843   GH927305   Y09258 CAA70455
UniProtKB/Swiss-Prot	Q94517
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage & larval stage & adult stage     (De Rubertis et al., 1996) larval stage   eye-antennal disc   (De Rubertis et al., 1996)
Additional Descriptive Data
	Transcripts are observed in RNA from embryos, larvae, and adults on northern blots. An insertion 1.8kb upstream of the Rpd3 gene causes a substantial reduction in transcript levels in the eye-antennal disc. (De Rubertis et al., 1996)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 4   organism   • nucleus (Chen et al., 1999) embryonic stage 9 -- 10   embryonic head | restricted   • nucleus (Chen et al., 1999) oogenesis   nurse cell   • nucleus (Chen et al., 1999) follicle cell   • nucleus (Chen et al., 1999)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0015805    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0015805 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0015805 expression level Developmental Stage   Expression Level embryo 00-02hr    15590 embryo 02-04hr    29309 embryo 04-06hr    32356 embryo 06-08hr    22230 embryo 08-10hr    15426 embryo 10-12hr    9497 embryo 12-14hr    7637 embryo 14-16hr    7122 embryo 16-18hr    5483 embryo 18-20hr    2851 embryo 20-22hr    7465 embryo 22-24hr    5485 larva L1    2788 larva L2    3856 larva L3 12hr old    2640 larva L3 puffstage 1-2    3405 larva L3 puffstage 3-6    4713 larva L3 puffstage 7-9    5473 white prepupae new    5507 white prepupae 12hr    5407 white prepupae 24hr    6806 pupae 2d postWPP    3350 pupae 3d postWPP    995 pupae 4d postWPP    1119 adult male 01day    1127 adult male 05day    1244 adult male 30day    1445 adult female 01day    4497 adult female 05day    7467 adult female 30day    7841 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (15590) embryo 02-04hr  (29309) embryo 04-06hr  (32356) embryo 06-08hr  (22230) embryo 08-10hr  (15426) embryo 10-12hr  (9497) embryo 12-14hr  (7637) embryo 14-16hr  (7122) embryo 16-18hr  (5483) embryo 18-20hr  (2851) embryo 20-22hr  (7465) embryo 22-24hr  (5485) larva L1  (2788) larva L2  (3856) larva L3 12hr old  (2640) larva L3 puffstage 1-2  (3405) larva L3 puffstage 3-6  (4713) larva L3 puffstage 7-9  (5473) white prepupae new  (5507) white prepupae 12hr  (5407) white prepupae 24hr  (6806) pupae 2d postWPP  (3350) pupae 3d postWPP  (995) pupae 4d postWPP  (1119) adult male 01day  (1127) adult male 05day  (1244) adult male 30day  (1445) adult female 01day  (4497) adult female 05day  (7467) adult female 30day  (7841) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (15590) embryo 02-04hr  (29309) embryo 04-06hr  (32356) embryo 06-08hr  (22230) embryo 08-10hr  (15426) embryo 10-12hr  (9497) embryo 12-14hr  (7637) embryo 14-16hr  (7122) embryo 16-18hr  (5483) embryo 18-20hr  (2851) embryo 20-22hr  (7465) embryo 22-24hr  (5485) larva L1  (2788) larva L2  (3856) larva L3 12hr old  (2640) larva L3 puffstage 1-2  (3405) larva L3 puffstage 3-6  (4713) larva L3 puffstage 7-9  (5473) white prepupae new  (5507) white prepupae 12hr  (5407) white prepupae 24hr  (6806) pupae 2d postWPP  (3350) pupae 3d postWPP    995 pupae 4d postWPP    1119 adult male 01day    1127 adult male 05day    1244 adult male 30day  1445 adult female 01day  (4497) adult female 05day  (7467) adult female 30day  (7841) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (15590) embryo 02-04hr  (29309) embryo 04-06hr  (32356) embryo 06-08hr  (22230) embryo 08-10hr  (15426) embryo 10-12hr    9497 embryo 12-14hr    7637 embryo 14-16hr    7122 embryo 16-18hr    5483 embryo 18-20hr    2851 embryo 20-22hr    7465 embryo 22-24hr    5485 larva L1    2788 larva L2    3856 larva L3 12hr old    2640 larva L3 puffstage 1-2    3405 larva L3 puffstage 3-6    4713 larva L3 puffstage 7-9    5473 white prepupae new    5507 white prepupae 12hr    5407 white prepupae 24hr    6806 pupae 2d postWPP    3350 pupae 3d postWPP    995 pupae 4d postWPP    1119 adult male 01day    1127 adult male 05day    1244 adult male 30day    1445 adult female 01day    4497 adult female 05day    7467 adult female 30day    7841 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    15590 embryo 02-04hr    29309 embryo 04-06hr    32356 embryo 06-08hr    22230 embryo 08-10hr    15426 embryo 10-12hr    9497 embryo 12-14hr    7637 embryo 14-16hr    7122 embryo 16-18hr    5483 embryo 18-20hr    2851 embryo 20-22hr    7465 embryo 22-24hr    5485 larva L1    2788 larva L2    3856 larva L3 12hr old    2640 larva L3 puffstage 1-2    3405 larva L3 puffstage 3-6    4713 larva L3 puffstage 7-9    5473 white prepupae new    5507 white prepupae 12hr    5407 white prepupae 24hr    6806 pupae 2d postWPP    3350 pupae 3d postWPP    995 pupae 4d postWPP    1119 adult male 01day    1127 adult male 05day    1244 adult male 30day    1445 adult female 01day    4497 adult female 05day    7467 adult female 30day    7841 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0015805 expression level Developmental Stage   Expression Level embryo 00-02hr    15590 embryo 02-04hr    29309 embryo 04-06hr    32356 embryo 06-08hr    22230 embryo 08-10hr    15426 embryo 10-12hr    9497 embryo 12-14hr    7637 embryo 14-16hr    7122 embryo 16-18hr    5483 embryo 18-20hr    2851 embryo 20-22hr    7465 embryo 22-24hr    5485 larva L1    2788 larva L2    3856 larva L3 12hr old    2640 larva L3 puffstage 1-2    3405 larva L3 puffstage 3-6    4713 larva L3 puffstage 7-9    5473 white prepupae new    5507 white prepupae 12hr    5407 white prepupae 24hr    6806 pupae 2d postWPP    3350 pupae 3d postWPP    995 pupae 4d postWPP    1119 adult male 01day    1127 adult male 05day    1244 adult male 30day    1445 adult female 01day    4497 adult female 05day    7467 adult female 30day    7841 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (15590) embryo 02-04hr  (29309) embryo 04-06hr  (32356) embryo 06-08hr  (22230) embryo 08-10hr  (15426) embryo 10-12hr  (9497) embryo 12-14hr  (7637) embryo 14-16hr  (7122) embryo 16-18hr  (5483) embryo 18-20hr  (2851) embryo 20-22hr  (7465) embryo 22-24hr  (5485) larva L1  (2788) larva L2  (3856) larva L3 12hr old  (2640) larva L3 puffstage 1-2  (3405) larva L3 puffstage 3-6  (4713) larva L3 puffstage 7-9  (5473) white prepupae new  (5507) white prepupae 12hr  (5407) white prepupae 24hr  (6806) pupae 2d postWPP  (3350) pupae 3d postWPP  (995) pupae 4d postWPP  (1119) adult male 01day  (1127) adult male 05day  (1244) adult male 30day  (1445) adult female 01day  (4497) adult female 05day  (7467) adult female 30day  (7841) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (15590) embryo 02-04hr  (29309) embryo 04-06hr  (32356) embryo 06-08hr  (22230) embryo 08-10hr  (15426) embryo 10-12hr  (9497) embryo 12-14hr  (7637) embryo 14-16hr  (7122) embryo 16-18hr  (5483) embryo 18-20hr  (2851) embryo 20-22hr  (7465) embryo 22-24hr  (5485) larva L1  (2788) larva L2  (3856) larva L3 12hr old  (2640) larva L3 puffstage 1-2  (3405) larva L3 puffstage 3-6  (4713) larva L3 puffstage 7-9  (5473) white prepupae new  (5507) white prepupae 12hr  (5407) white prepupae 24hr  (6806) pupae 2d postWPP  (3350) pupae 3d postWPP    995 pupae 4d postWPP    1119 adult male 01day    1127 adult male 05day    1244 adult male 30day  1445 adult female 01day  (4497) adult female 05day  (7467) adult female 30day  (7841) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  15590 embryo 02-04hr  (29309) embryo 04-06hr  (32356) embryo 06-08hr  (22230) embryo 08-10hr  15426 embryo 10-12hr    9497 embryo 12-14hr    7637 embryo 14-16hr    7122 embryo 16-18hr    5483 embryo 18-20hr    2851 embryo 20-22hr    7465 embryo 22-24hr    5485 larva L1    2788 larva L2    3856 larva L3 12hr old    2640 larva L3 puffstage 1-2    3405 larva L3 puffstage 3-6    4713 larva L3 puffstage 7-9    5473 white prepupae new    5507 white prepupae 12hr    5407 white prepupae 24hr    6806 pupae 2d postWPP    3350 pupae 3d postWPP    995 pupae 4d postWPP    1119 adult male 01day    1127 adult male 05day    1244 adult male 30day    1445 adult female 01day    4497 adult female 05day    7467 adult female 30day    7841 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    15590 embryo 02-04hr    29309 embryo 04-06hr    32356 embryo 06-08hr    22230 embryo 08-10hr    15426 embryo 10-12hr    9497 embryo 12-14hr    7637 embryo 14-16hr    7122 embryo 16-18hr    5483 embryo 18-20hr    2851 embryo 20-22hr    7465 embryo 22-24hr    5485 larva L1    2788 larva L2    3856 larva L3 12hr old    2640 larva L3 puffstage 1-2    3405 larva L3 puffstage 3-6    4713 larva L3 puffstage 7-9    5473 white prepupae new    5507 white prepupae 12hr    5407 white prepupae 24hr    6806 pupae 2d postWPP    3350 pupae 3d postWPP    995 pupae 4d postWPP    1119 adult male 01day    1127 adult male 05day    1244 adult male 30day    1445 adult female 01day    4497 adult female 05day    7467 adult female 30day    7841 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0015805    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0015805 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system, adult crop, larval/adult hindgut, larval/adult Malpighian tubules, larval/adult salivary gland, larval trachea, adult ovary, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0015805 expression level Tissue   Expression Level Larval Central Nervous System    692.25 Larval Midgut    49.3 Larval Hindgut    142.4 Larval Malpighian Tubules    124.9 Larval Fat Body    70 Larval Salivary Gland    323.4 Larval Trachea    224.8 Larval Carcass    157.7 Adult Head    82.5 Adult Eye    54.975 Adult Brain    158.7 Adult Thoracic-Abdominal Ganglion    111.7 Adult Crop    141.5 Adult Midgut    77.5 Adult Hindgut    117.2 Adult Malpighian Tubules    170.7 Adult Fat Body    76.3 Adult Salivary Gland    123.7 Adult Heart    89 Adult VirginFemale Spermatheca    71.5 Adult InseminatedFemale Spermatheca    79.2 Adult Ovary    448.2 Adult Testis    20 Adult Male Accessory Gland    133.1 Adult Carcass    63.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (692.25) Larval Midgut    49.3 Larval Hindgut    142.4 Larval Malpighian Tubules    124.9 Larval Fat Body    70 Larval Salivary Gland    323.4 Larval Trachea    224.8 Larval Carcass    157.7 Adult Head    82.5 Adult Eye    54.975 Adult Brain    158.7 Adult Thoracic-Abdominal Ganglion    111.7 Adult Crop    141.5 Adult Midgut    77.5 Adult Hindgut    117.2 Adult Malpighian Tubules    170.7 Adult Fat Body    76.3 Adult Salivary Gland    123.7 Adult Heart    89 Adult VirginFemale Spermatheca    71.5 Adult InseminatedFemale Spermatheca    79.2 Adult Ovary    448.2 Adult Testis    20 Adult Male Accessory Gland    133.1 Adult Carcass    63.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    692.25 Larval Midgut    49.3 Larval Hindgut    142.4 Larval Malpighian Tubules    124.9 Larval Fat Body    70 Larval Salivary Gland    323.4 Larval Trachea    224.8 Larval Carcass    157.7 Adult Head    82.5 Adult Eye    54.975 Adult Brain    158.7 Adult Thoracic-Abdominal Ganglion    111.7 Adult Crop    141.5 Adult Midgut    77.5 Adult Hindgut    117.2 Adult Malpighian Tubules    170.7 Adult Fat Body    76.3 Adult Salivary Gland    123.7 Adult Heart    89 Adult VirginFemale Spermatheca    71.5 Adult InseminatedFemale Spermatheca    79.2 Adult Ovary    448.2 Adult Testis    20 Adult Male Accessory Gland    133.1 Adult Carcass    63.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    692.25 Larval Midgut    49.3 Larval Hindgut    142.4 Larval Malpighian Tubules    124.9 Larval Fat Body    70 Larval Salivary Gland    323.4 Larval Trachea    224.8 Larval Carcass    157.7 Adult Head    82.5 Adult Eye    54.975 Adult Brain    158.7 Adult Thoracic-Abdominal Ganglion    111.7 Adult Crop    141.5 Adult Midgut    77.5 Adult Hindgut    117.2 Adult Malpighian Tubules    170.7 Adult Fat Body    76.3 Adult Salivary Gland    123.7 Adult Heart    89 Adult VirginFemale Spermatheca    71.5 Adult InseminatedFemale Spermatheca    79.2 Adult Ovary    448.2 Adult Testis    20 Adult Male Accessory Gland    133.1 Adult Carcass    63.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0015805 expression level Tissue   Expression Level Larval Central Nervous System    692.25 Larval Midgut    49.3 Larval Hindgut    142.4 Larval Malpighian Tubules    124.9 Larval Fat Body    70 Larval Salivary Gland    323.4 Larval Trachea    224.8 Larval Carcass    157.7 Adult Head    82.5 Adult Eye    54.975 Adult Brain    158.7 Adult Thoracic-Abdominal Ganglion    111.7 Adult Crop    141.5 Adult Midgut    77.5 Adult Hindgut    117.2 Adult Malpighian Tubules    170.7 Adult Fat Body    76.3 Adult Salivary Gland    123.7 Adult Heart    89 Adult VirginFemale Spermatheca    71.5 Adult InseminatedFemale Spermatheca    79.2 Adult Ovary    448.2 Adult Testis    20 Adult Male Accessory Gland    133.1 Adult Carcass    63.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  692.25 Larval Midgut    49.3 Larval Hindgut    142.4 Larval Malpighian Tubules    124.9 Larval Fat Body    70 Larval Salivary Gland    323.4 Larval Trachea    224.8 Larval Carcass    157.7 Adult Head    82.5 Adult Eye    54.975 Adult Brain    158.7 Adult Thoracic-Abdominal Ganglion    111.7 Adult Crop    141.5 Adult Midgut    77.5 Adult Hindgut    117.2 Adult Malpighian Tubules    170.7 Adult Fat Body    76.3 Adult Salivary Gland    123.7 Adult Heart    89 Adult VirginFemale Spermatheca    71.5 Adult InseminatedFemale Spermatheca    79.2 Adult Ovary    448.2 Adult Testis    20 Adult Male Accessory Gland    133.1 Adult Carcass    63.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    692.25 Larval Midgut    49.3 Larval Hindgut    142.4 Larval Malpighian Tubules    124.9 Larval Fat Body    70 Larval Salivary Gland    323.4 Larval Trachea    224.8 Larval Carcass    157.7 Adult Head    82.5 Adult Eye    54.975 Adult Brain    158.7 Adult Thoracic-Abdominal Ganglion    111.7 Adult Crop    141.5 Adult Midgut    77.5 Adult Hindgut    117.2 Adult Malpighian Tubules    170.7 Adult Fat Body    76.3 Adult Salivary Gland    123.7 Adult Heart    89 Adult VirginFemale Spermatheca    71.5 Adult InseminatedFemale Spermatheca    79.2 Adult Ovary    448.2 Adult Testis    20 Adult Male Accessory Gland    133.1 Adult Carcass    63.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    692.25 Larval Midgut    49.3 Larval Hindgut    142.4 Larval Malpighian Tubules    124.9 Larval Fat Body    70 Larval Salivary Gland    323.4 Larval Trachea    224.8 Larval Carcass    157.7 Adult Head    82.5 Adult Eye    54.975 Adult Brain    158.7 Adult Thoracic-Abdominal Ganglion    111.7 Adult Crop    141.5 Adult Midgut    77.5 Adult Hindgut    117.2 Adult Malpighian Tubules    170.7 Adult Fat Body    76.3 Adult Salivary Gland    123.7 Adult Heart    89 Adult VirginFemale Spermatheca    71.5 Adult InseminatedFemale Spermatheca    79.2 Adult Ovary    448.2 Adult Testis    20 Adult Male Accessory Gland    133.1 Adult Carcass    63.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    82.5   NA  Eye    54.975   NA  Brain    158.7   692.25  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    111.7   NA  Crop    141.5   49.3  Midgut    77.5   142.4  Hindgut    117.2   124.9  Malpighian Tubules    170.7   70  Fat Body    76.3   323.4  Salivary Gland    123.7   NA  Heart    89   224.8  Trachea    NA   NA  VirginFemale Spermatheca    71.5   NA  InseminatedFemale Spermatheca    79.2   NA  Ovary    448.2   NA  Testis    20   NA  Male Accessory Gland    133.1   157.7  Carcass    63.2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015805 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7471-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Rpd3 Stages(s) 7-8 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal Rpd3CB04302 lethal, with Scer\GAL41407 Rpd3GD17233 lethal, with Scer\GAL4tub.PU Rpd3dsRNA.Scer\UAS.R15 lethal | embryonic stage | germline clone | pair rule expression pattern Rpd304556 lethal | embryonic stage | germline clone | pair rule expression pattern | recessive Rpd304556 lethal | embryonic stage | maternal effect | poor Rpd304556 lethal | larval stage | recessive Rpd3313 Rpd3326 Rpd3def8 Rpd3def24 lethal | polyphasic | recessive Rpd304556 lethal | pupal stage Rpd3X5 lethal | pupal stage (with Rpd33-10) Rpd3X5 lethal | pupal stage (with Rpd3X5) Rpd33-10 lethal | recessive Rpd31-3 Rpd33-10 Rpd34-4 Rpd35-2 Rpd35-5 Rpd3303 Rpd3326 Rpd3328 Rpd304556 lethal | second instar larval stage Rpd33-10 lethal | second instar larval stage (with Rpd33-10) Rpd35-5 lethal | second instar larval stage (with Rpd35-5) Rpd33-10 semi-lethal Rpd304556 semi-lethal | dominant | male Rpd3303 Rpd3313 Rpd3326 Rpd3328 semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 Rpd3GD4513 semi-lethal | recessive Rpd304556 viable Rpd315-1 viable, with Scer\GAL4Mef2.PR Rpd3dsRNA.Scer\UAS.R15 Sterility Allele fertile Rpd315-1 fertile, with Scer\GAL4Mef2.PR Rpd3dsRNA.Scer\UAS.R15 Other Phenotypes Allele decreased cell number | somatic clone Rpd33-10 decreased cell number | somatic clone (with Rpd33-10) Rpd3X5 decreased cell number | somatic clone (with Rpd3X5) Rpd33-10 enhancer of variegation, with In(1)wm4 Rpd315-1 enhancer of variegation | dominant, with In(1)wm4 Rpd315-1 increased cell death | somatic clone Rpd33-10 long lived Rpd3def24 long lived | dominant | female Rpd304556 long lived | dominant | male Rpd304556 Rpd3def24 mitotic cell cycle defective Rpd35-5 mitotic cell cycle defective | somatic clone Rpd33-10 mitotic cell cycle defective | somatic clone (with Rpd33-10) Rpd3X5 mitotic cell cycle defective | somatic clone (with Rpd3X5) Rpd33-10 neuroanatomy defective | larval stage, with Scer\GAL41407 Rpd3GD17233 neuroanatomy defective | somatic clone Rpd312-37 Rpd3303 Rpd3def24 suppressor of variegation Rpd3326 suppressor of variegation | dominant, with In(1)wm4 Rpd3303 Rpd3313 Rpd3326 Rpd3328 suppressor of variegation | dominant, with In(2R)bwVDe2 Rpd3326 Rpd3328 suppressor of variegation | dominant, with T(2;3)SbV Rpd3326 Rpd3328 suppressor of variegation | dominant | female, with In(2R)bwVDe2 Rpd3326 Rpd3328 suppressor of variegation | recessive, with In(1)wm4 Rpd315-1 Rpd304556 visible, with Scer\GAL4pnr-MD237 Rpd3GD4513 visible | drug conditional Rpd304556 Phenotype manifest in Allele adult antennal lobe projection neuron DL1 adPN | somatic clone Rpd3303 Rpd3def24 Rpd312-37 alula Rpd304556 Rpd3303 cephalopharyngeal skeleton | germline clone Rpd304556 cuticle | maternal effect Rpd304556 denticle belt | germline clone Rpd304556 embryo | germline clone | pair rule expression pattern Rpd304556 embryonic epidermis | germline clone | pair rule expression pattern Rpd304556 embryonic segment | pair rule expression pattern Rpd304556 ganglion mother cell | larval stage, with Scer\GAL41407 Rpd3GD17233 macrochaeta Rpd304556 Rpd3303 mesothoracic tergum, with Scer\GAL4pnr-MD237 Rpd3GD4513 ommatidium Rpd315-1 projection neuron | somatic clone Rpd312-37 segment | maternal effect | pair rule expression pattern Rpd304556 sex comb Rpd304556 Rpd3303 wing Rpd304556 Rpd3303 wing | drug conditional Rpd304556 wing disc Rpd3X5 wing disc | somatic clone Rpd33-10 wing disc | somatic clone (with Rpd33-10) Rpd3X5 wing disc | somatic clone (with Rpd3X5) Rpd33-10
Classical Alleles ( 21 )
For All Classical Alleles Show
Allele of Rpd3 Class Mutagen Stocks Known lesion Rpd3303 hypomorphic allele - genetic evidence 2 Yes Rpd304556 loss of function allele, hypomorphic allele - genetic evidence P-element activity 1 Yes Rpd312-37 ethyl methanesulfonate 1 Yes Rpd3328 hypomorphic allele - genetic evidence ethyl methanesulfonate 1 Yes Rpd3c04194 piggyBac transposase 1 -- Rpd3def24 loss of function allele Delta2-3 1 Yes Rpd3e01851 piggyBac transposase 1 -- Rpd31-3 ethyl methanesulfonate 0 -- Rpd315-1 loss of function allele P-element activity 0 Yes Rpd31 0 -- Rpd33-10 ethyl methanesulfonate 0 Yes Rpd3313 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes Rpd3326 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes Rpd34-4 ethyl methanesulfonate 0 -- Rpd35-2 ethyl methanesulfonate 0 -- Rpd35-5 ethyl methanesulfonate 0 Yes Rpd3CB04302 P-element activity 0 Yes Rpd3def8 loss of function allele Delta2-3 0 Yes Rpd3EP3672 P-element activity 0 Yes Rpd3unspecified 0 -- Rpd3X5 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 15 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Rpd3 Class Mutagen Stocks Known lesion Rpd3GD17233 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Rpd3GD4513 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Rpd3Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion 2 Yes Rpd3HMS00164 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Rpd3HMS00607 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Rpd3JF01401 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Rpd3Act5C.T:SV5\V5,T:Zzzz\His6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Rpd3Act5C.T:Zzzz\His6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Rpd3dsRNA.Scer\UAS.R15 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Rpd3H196F.Act5C.T:Scer\GAL4 in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes Rpd3H196F.Act5C in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes Rpd3hs.T:Ecol\dam,T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Rpd3hs.T:Scer\GAL4 in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes Rpd3WT.Act5C.T:Scer\GAL4 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Rpd3WT.Act5C.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)10H (Chen et al., 1999, Chang et al., 2001, Gepner et al., 1996) Df(3L)Exel7208 (Ryder, 2004.4.26) Df(3L)GN24 (Spradling et al., 1999, Mottus et al., 2000, BDGP Project Members, 1994-1999, Spradling et al., 1995)
Not disrupted in	Df(3L)ZN47 (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4513} NA P{GD17233} NA P{TRiP.HMS00164} NA P{TRiP.HMS00607} NA P{TRiP.JF01401} NA P{UAS-Rpd3.V5} NA heat-shock construct P{hs-Rpd3.T:GAL4} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{PZ}Rpd304556 No miscellaneous insertions P{hsneo.ry+}Rpd315-1 NA P{PTT-GB}Rpd3CB04302 NA PBac{PB}Rpd3c04194 NA PBac{RB}Rpd3e01851 NA insertion of mobile activating element P{EP}Rpd3EP3672 NA
Gene Ontology: Function, Process & Cellular Component ( 29 unique terms )
Terms Based on Experimental Evidence ( 27 terms )
Molecular Function
CV term Evidence References
histone deacetylase activity inferred from direct assay (Barlow et al., 2001, Huang and Kadonaga, 2001, Cho et al., 2005, Miotto et al., 2006) protein binding inferred from physical interaction with mip120 (Lewis et al., 2004) inferred from physical interaction with Pcl (assigned by UniProtKB) (Tie et al., 2003) inferred from physical interaction with Smyd4 (Thompson and Travers, 2008) transcription corepressor activity inferred from physical interaction with kay (Miotto et al., 2006)
Biological Process
CV term Evidence References
blastoderm segmentation inferred from mutant phenotype (Mannervik and Levine, 1999) chromatin silencing inferred from genetic interaction with Hdac3 (Zhu et al., 2008) inferred from genetic interaction with Pc AND inferred from physical interaction with Pc (Chang et al., 2001) inferred from mutant phenotype (Zhu et al., 2008) inferred from physical interaction with E(z) AND inferred from physical interaction with esc (Tie et al., 2001) dendrite guidance inferred from mutant phenotype (Tea et al., 2010) dendrite morphogenesis inferred from mutant phenotype (Parrish et al., 2006) determination of adult lifespan inferred from mutant phenotype (Rogina et al., 2002) gene silencing inferred from mutant phenotype (Tie et al., 2001) histone deacetylation inferred from mutant phenotype (Pile et al., 2002, Tea et al., 2010) muscle organ development inferred from mutant phenotype (Parrish et al., 2006) negative regulation of axonogenesis inferred from mutant phenotype (Tea et al., 2010) negative regulation of transcription, DNA-dependent inferred from expression pattern (Pile and Wassarman, 2000) negative regulation of transcription from RNA polymerase II promoter inferred from direct assay (Miotto et al., 2006) neurogenesis inferred from mutant phenotype (Neumüller et al., 2011) regulation of transcription, DNA-dependent inferred from direct assay (Cho et al., 2005) respiratory electron transport chain inferred from direct assay (Chen et al., 2008) tricarboxylic acid cycle inferred from direct assay (Chen et al., 2008)
Cellular Component
CV term Evidence References
chromatin inferred from direct assay (Pile and Wassarman, 2000) ESC/E(Z) complex inferred from direct assay (Czermin et al., 2002) Myb complex inferred from direct assay (Lewis et al., 2004) nucleus inferred from direct assay (Pile and Wassarman, 2000, Tie et al., 2001, Cho et al., 2005, Czermin et al., 2002, Miotto et al., 2006) NuRD complex inferred from physical interaction with Mi-2 (Murawsky et al., 2001) polytene chromosome inferred from direct assay (Burgio et al., 2008) polytene chromosome interband inferred from direct assay (Wang et al., 2008) Sin3-type complex inferred from direct assay (Spain et al., 2010) transcriptional repressor complex inferred from physical interaction with CoRest (Dallman et al., 2004) inferred from physical interaction with Su(var)3-3 (Dallman et al., 2004)
Terms Based on Predictions or Assertions ( 10 terms )
Molecular Function
CV term Evidence References
histone deacetylase activity inferred from sequence or structural similarity with human HDAC1 AND inferred from sequence or structural similarity with Saccharomyces RPD3 (De Rubertis et al., 1996) inferred from sequence or structural similarity with UniProtKB:P56517 (FlyBase, 1992-) non-traceable author statement (Spierer, 1996.11.6, Courey and Jia, 2001, Swiss-Prot Project Members, 1998.2.1) transcription corepressor activity non-traceable author statement (Courey and Jia, 2001)
Biological Process
CV term Evidence References
determination of adult lifespan traceable author statement (Helfand and Rogina, 2003) histone deacetylation non-traceable author statement (Courey and Jia, 2001, Swiss-Prot Project Members, 1998.2.1) negative regulation of transcription, DNA-dependent non-traceable author statement (Courey and Jia, 2001) oogenesis traceable author statement (Courey and Jia, 2001)
Cellular Component
CV term Evidence References
ESC/E(Z) complex traceable author statement (Lehmann, 2004) nucleus non-traceable author statement (Swiss-Prot Project Members, 1998.2.1) NuRD complex non-traceable author statement (Pile and Wassarman, 2000) Sin3 complex non-traceable author statement (Pile and Wassarman, 2000)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Rpd3 allele Gene References Rpd31-3 ttk (Murawsky et al., 2001) Rpd33-10 ttk (Murawsky et al., 2001) Rpd35-5 Snr1 (Zraly et al., 2004) ttk (Murawsky et al., 2001) Rpd3303 Pc (Chang et al., 2001) Rpd3313 Pc (Chang et al., 2001) Rpd3326 Pc (Chang et al., 2001) Rpd304556 bcd (Singh et al., 2005) Ctet\TeTxLC (Bauer et al., 2004) gro (Chen et al., 1999) net (Marenda et al., 2004) Pc (Chang et al., 2001) sev (Maixner et al., 1998) Snr1 (Zraly et al., 2004) Rpd3def8 Pc (Chang et al., 2001) Rpd3def24 Ctet\TeTxLC (Bauer et al., 2004) Sir2 (Rogina and Helfand, 2004) unspecified chm (Miotto et al., 2006) H (Mueller et al., 2005) hep (Miotto et al., 2006) kni (Struffi and Arnosti, 2005) UbxPRE (Tie et al., 2001)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64037 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0015805 DroID - A comprehensive database of gene and protein interactions. • FBgn0015805 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38565
Orthologs
Genome-wide drosophilid orthologs	Dana\GF25085 Dere\GG15241 Dgri\GH15691 Dmoj\GI12742 Dper\GL22935 Dpse\GA20378 Dsec\GM14673 Dsim\GD13856 Dvir\GJ15512 Dwil\GK16595 Dyak\GE21462
Curated drosophilid orthologs	Dpse\GA20378
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL004586-PB Aedes aegypti (mosquito) AGAP006511-PA Anopheles gambiae (mosquito) XP_394976.3 Apis mellifera (honey bee) XP_001946324.1 Acyrthosiphon pisum (pea aphid) At4g38130.1 Arabidopsis thaliana (wall cress) 24371 Batrachochytrium dendrobatidis (chytrid fungus) 110155 Branchiostoma floridae (lancelet) 217516 Branchiostoma floridae (lancelet) XP_001893332.1 Brugia malayi (roundworm nematode) BGIBMGA011747-PA Bombyx mori (silk worm) ENSBTAP00000016877 Bos taurus (bovine) CAL0005608 Candida albicans (a form of yeast) CN09019 Caenorhabditis brenneri (small nematode) CN23516 Caenorhabditis brenneri (small nematode) CBP06924 Caenorhabditis briggsae (nematode) CE08952 Caenorhabditis elegans (worm) ENSCAFP00000015619 Canis familiaris (dog) CAGL0B01441g Candida glabrata (haploid yeast) Chro.60019 Cryptosporidium hominis (obligate parasite) ENSCINP00000005410 Ciona intestinalis (sea squirt) JA06842 Caenorhabditis japonica (nematode) CMJ129C Cyanidioschyzon merolae (red alga) cn06189 Cryptococcus neoformans (yeast-like fungus) cgd6_80 Cryptosporidium parvum (protozoan parasite) CPIJ006836 Culex pipens (mosquito) ENSCPOP00000012920 Cavia porcellus (guinea pig) 137868 Chlamidomonas reinhardtii (green alga) RP07215 Caenorhabditis remanei (nematode) ENSCSAVP00000018216 Ciona savignyi (sedentary tunicate) 175897 Capitella spl (polychaete worm) DDB0234190 Dictyostelium discoideum (amoeba) DEHA2F02420g Debaryomyces Hansenii (yeast) 306940 Daphnia pulex (daphnia) ENSDARP00000051798 Danio rerio (zebra fish) ENSECAP00000014039 Equus caballus (horse) XP_650263 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000009568 Gymnopilus aculeatus (mushroom) ENSGALP00000024133 Gallus gallus (chicken) GL50803_3281 Giardia lamblia (flagellated protozoan) 194553 Hypsipyla robusta (cedar shoot borer) ENSP00000381331 Homo sapiens (human) ISCW007830-PA Ixodes scapularis (deer tick) KLLA0E01981g Kluyveromyces lactis (yeast) 178649 Lottia gigantea (owl limpet) LmjF21.0680 Leishmania major (virus) 34892 Monocosta brevicollis (choanoflagellate) ENSMODP00000022264 Monodelphis domestica (gray opossum) ENSMMUP00000011716 Macaca mulatta (rhesus monkey) ENSMUSP00000019911 Mus musculus (house mouse) 79092 Nematostella vectensis (starlet anemone) XP_001600613.1 Nasonia vitripennis (wasp) ENSOANP00000005760 Ornithorynchus anatinus (platypus) ENSORLP00000022529 Oryzias latipes (japanese killifish) LOC_Os06g38470.1 Oryza sativa (asian rice) 27561 Ostreococcus tauri (green alga) PFI1260c Plasmodium falciparum (protozoal parasite) PHUM003084-PA Pediculus humanus (human body louse) PP28858 Pristionchus pacificus (nematode) 145029 Physcomitrella patens (moss) 199053 Physcomitrella patens (moss) ENSPPYP00000018964 Pongo pygmaeus (orangutan) 71132 Phytophthora ramorum (sudden oak death pathogen) 108792 Phytophthora sojae (root rot pathogen) 803954 Populus trichocarpa (black cottonwood) ENSPTRP00000049696 Pan troglodytes (chimpanzee) PVX_099700 Plasmodium vivax (protozoal parasite) ENSRNOP00000000742 Rattus norvegicus (norway rat) 4897718 Sorghum bicolor (sorghum) YNL330C Saccharomyces cerevisiae (budding yeast) Smp_005210 Schistosoma mansoni (trematode parasite) SPBC36.05c Schizosaccharomyces pombe (fission yeast) NP_999711.1 Strongylocentrotus purpuratus (purple sea urchin) 64072 Trichoplax adhaerens (metazoa) TA12690 Theileria annulata (apicomplexan parasite) XP_966633.1 Tribolium castaneum (red flour beetle) Tc00.1047053508637.114 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511911.159 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000020022 Tetraodon nigroviridis (green spotted pufferfish) TP02_0039 Theileria parva (parasitic protozoan) 41025 Thalassiosira pseudonana (marine diatom) ENSTRUP00000016628 Takifugu rubripes (pufferfish Takifugu) 3727.m00055 Tetrahymena thermophila (ciliate protozoa) 86485.m00643 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000011480 Xenopus tropicalis (frog) ENSXETP00000015978 Xenopus tropicalis (frog) YALI0E22935g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV18066 LH20273 LH17263 ISCW007830 FBgn0238719 FBgn0218597 FBgn0202705 FBgn0185553 FBgn0169594 JGI_V11_306940 FBgn0080373 FBgn0160525 FBgn0159598 FBgn0155513 FBgn0135499 FBgn0123162 FBgn0107493 FBgn0102077 CPIJ006836 BGIBMGA011747 ACYPI007884 ACYPI006180 ACYPI003204 ACYPI001259 GB14706 AGAP006511 AAEL004586 PB21115 PB21117 PHUM158460 GLEAN_02540
Stocks & Reagents
Stocks Listed in FlyBase ( 17 )
Bloomington	32241 y1 w*; P{UAS-Rpd3.V5}K2a 32242 y1 w*; P{UAS-Rpd3.V5}A2a 31616 y1 v1; P{TRiP.JF01401}attP2 33725 y1 sc* v1; P{TRiP.HMS00607}attP2 34846 y1 sc* v1; P{TRiP.HMS00164}attP2 11633 P{PZ}Rpd304556 ry506/TM3, ryRK Sb1 Ser1
Harvard	- PBac{PB}Rpd3c04194 - PBac{RB}Rpd3e01851
VDRC	v30600 w1118; P{GD4513}v30600 v30599 w1118; P{GD4513}v30599/TM3 v46929 w1118; P{GD17233}v46929/TM3 v46930 w1118; P{GD17233}v46930/TM3
	More stocks available...
Genomic Clones ( 1 )
	BACR23H09 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 185 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM14158
Other clones	DPiM_GM14158
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH06224 GH12844 GM08668 GM29592 LD01082 LD01433 LD02133 LD02546 LD02817 LD04115 LD04304 LD04484 LD04593 LD06478 LD06915 LD07541 LD07940 LD08522 LD11807 LD11924 LD12009 LD12051 LD12448 LD14778 LD15455 LD15593 LD17138 LD17467 LD17826 LD18520 LD19588 LD20785 LD21133 LD21244 LD21903 LD23661 LD23895 LD25539 LD25588 LD27444 LD28326 LD29712 LD29908 LD30942 LD33634 LD33773 LD35316 LD36270 LD36966 LD37094 LD37860 LD38183 LD38428 LD38739 LD39380 LD39956 LD40204 LD40853 LD42813 LD43249 LD45172 LD45617 LD46674 LP01186 LP01603 LP03581 LP05782 LP24196 RE02640 RE04296 RE15784 RE16476 RE19781 RE20775 RE30428 RE32310 RE40060 RE46719 RE59444 RE63654 RE66645 RE68344 RE71629 RE73895 SD02852 SD05980 SD06331 SD07263 SD07947 SD08574 SD09537 SD12936 SD18614 SD18742 SD19214 SD22253 SD25932
Other clones	18052 35170 103304 103827 164404 183909 CK01.16D.B10 CK01.18B.H8 CK01.60D.E6 CK01.67B.G4 CK01.91D.G12 CK01.125D.C6 Dmel_dig_011314_0671_1101 Dmel_dig_014898_0644_2719 Dmel_neb_004221_0897_0288 DMG4-chr3L.9.004.pred.a EK054158 EK071760 EK131326 EK145253 EK186901 EK227146 EK269123 ESG012b.E21.3_E10 RP003010008 RP003015108 RP003016239 RP003029751 RP003043988 RP003045988 RP003081633 RP003100943 RP003104935 RP003120849 RP003121943 RP003124790 RP003126842 RP003132920 RP003135233 RP003135729 RP003150551 RP003154094 RP003157709 RP003158269 RP003158738 RP003170275 RP003178034 RP003184624 RP003198399 RP003215363 RP003231355 RP003234883 RP003239739 RP003246062 RP003273444 RP003278974 RP003279335 RP003279948 RP003280969 RP003294446 RP003299410 RP003304026 RP003316321 RP003326054 RP003327295 RP003358070 RP003369080 RP003394805 RP003395709 RP003403080 RP003407684 RP003455088 RP003458110 RP003480489 RP003525843 RP003527533 RP003531383 RP003569367 RP003570690 RP003588510 RP003594514 RP003603330 RP003646456 RP003678403 RP003679753 RP003682031
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0015805 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38565
Antibody Information
	polyclonal (Murawska et al., 2008, Chen et al., 2008, Chen et al., 1999)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Rpd3 l(3)64Cc (Murawsky et al., 2001) Source for merge of: Rpd3 l(3)04556 (Maixner et al., 1998) Source for merge of: Rpd3 Su(var)328 Su(var)326 (Mottus et al., 2000)
Additional comments
Other Comments
	DNA-protein interactions: genome-wide binding profile assayed for Rpd3 protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069). (Filion et al., 2010) Gene expression is increased in response to the presence of two copies of Scer\GAL4hs.PB. (Liu and Lehmann, 2008) S2 cell populations treated with dsRNA made from templates generated with primers directed against Rpd3 show inhibition of cell growth due to a G2 arrest. (Foglietti et al., 2006) chm and Rpd3 act as antagonistic cofactors of Jra and kay proteins to modulate JNK-dependent transcription during thorax metamorphosis and JNK-induced apoptosis. (Miotto et al., 2006) dsRNA has been made from templates generated with primers directed against this gene. RNAi of Rpd3 results in increased arborization of ddaD and ddaE neurons, defects in muscle, defects in dendrite morphogenesis and reproducible defects in da dendrite development. (Parrish et al., 2006) Rpd3 may be a component of the silencing complex for chromatin modification on specific regulatory regions of the homeotic genes. (Chang et al., 2001) The Rpd3 and Caf1 proteins are contained within a complex that includes also PcG proteins esc and E(z). (Tie et al., 2001) Rpd3 is required for PRE-mediated silencing in vivo. (Tie et al., 2001) Specific missense mutations in Rpd3 suppress the silencing of genes subject to PEV, perhaps by acting as antimorphs that poisen the deacetylase complex. (Mottus et al., 2000) Mutational analysis indicates that the Rpd3 histone deacetylase acts as a global transcriptional regulator. (Mottus et al., 2000) gro and Rpd3 appear to form a complex in vivo and interact directly via the glycine/proline rich (GP) domain. (Chen et al., 1999) Rpd3 is required for gro mediated repression and has a role in early pattern formation. (Chen et al., 1999) The Rpd3 histone deacetylase is required for segmentation of the Drosophila embryo. (Mannervik and Levine, 1999) Loss of Rpd3 results in increased genomic silencing, which decreases the distance from heterochromatin. (De Rubertis et al., 1996) Identified during a genetic analysis designed to identify mutations in the Dhc64C gene. (Gepner et al., 1996) The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(whs)} P{hsFLP} chromosomes) has been used to identify the specific maternal effect phenotype for the zygotic lethal mutation. (Perrimon et al., 1996) The presence of Rpd3 does not have any discernible effect on wzm, wzl, wzvl, wzh or wcres, this was not checked in X/0 males. (Peterson et al., 1994)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_139661 RefSeq (Proteins) • NP_647918 DDBJ / EMBL / GenBank • AA263673 AA803742 AAC23917 AAC61494 AAF47924 AAL13716 AF026949 AF086715 AI518989 AQ073107 AY058487 CAA70455 CZ469061 CZ479671 G00703 Y09258 Entrez Gene - A searchable database of RefSeq genes. • 38565 UniProtKB/Swiss-Prot • Q94517
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Histone deacetylase superfamily (IPR000286) Histone deacetylase (IPR003084) Histone deacetylase domain (IPR023801)
Linkouts
	BioGRID - A database of protein and genetic interactions • 64037 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0015805 DroID - A comprehensive database of gene and protein interactions. • FBgn0015805 DRSC - Results from RNAi screens. • FBgn0015805 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015805 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7471-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0015805 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 92081 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38565 InParanoid A subset of ortholog calls from InParanoid. • AAEL004586-PB Aedes aegypti (mosquito) AGAP006511-PA Anopheles gambiae (mosquito) XP_394976.3 Apis mellifera (honey bee) XP_001946324.1 Acyrthosiphon pisum (pea aphid) At4g38130.1 Arabidopsis thaliana (wall cress) 24371 Batrachochytrium dendrobatidis (chytrid fungus) 110155 Branchiostoma floridae (lancelet) 217516 Branchiostoma floridae (lancelet) XP_001893332.1 Brugia malayi (roundworm nematode) BGIBMGA011747-PA Bombyx mori (silk worm) ENSBTAP00000016877 Bos taurus (bovine) CAL0005608 Candida albicans (a form of yeast) CN09019 Caenorhabditis brenneri (small nematode) CN23516 Caenorhabditis brenneri (small nematode) CBP06924 Caenorhabditis briggsae (nematode) CE08952 Caenorhabditis elegans (worm) ENSCAFP00000015619 Canis familiaris (dog) CAGL0B01441g Candida glabrata (haploid yeast) Chro.60019 Cryptosporidium hominis (obligate parasite) ENSCINP00000005410 Ciona intestinalis (sea squirt) JA06842 Caenorhabditis japonica (nematode) CMJ129C Cyanidioschyzon merolae (red alga) cn06189 Cryptococcus neoformans (yeast-like fungus) cgd6_80 Cryptosporidium parvum (protozoan parasite) CPIJ006836 Culex pipens (mosquito) ENSCPOP00000012920 Cavia porcellus (guinea pig) 137868 Chlamidomonas reinhardtii (green alga) RP07215 Caenorhabditis remanei (nematode) ENSCSAVP00000018216 Ciona savignyi (sedentary tunicate) 175897 Capitella spl (polychaete worm) DDB0234190 Dictyostelium discoideum (amoeba) DEHA2F02420g Debaryomyces Hansenii (yeast) 306940 Daphnia pulex (daphnia) ENSDARP00000051798 Danio rerio (zebra fish) ENSECAP00000014039 Equus caballus (horse) XP_650263 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000009568 Gymnopilus aculeatus (mushroom) ENSGALP00000024133 Gallus gallus (chicken) GL50803_3281 Giardia lamblia (flagellated protozoan) 194553 Hypsipyla robusta (cedar shoot borer) ENSP00000381331 Homo sapiens (human) ISCW007830-PA Ixodes scapularis (deer tick) KLLA0E01981g Kluyveromyces lactis (yeast) 178649 Lottia gigantea (owl limpet) LmjF21.0680 Leishmania major (virus) 34892 Monocosta brevicollis (choanoflagellate) ENSMODP00000022264 Monodelphis domestica (gray opossum) ENSMMUP00000011716 Macaca mulatta (rhesus monkey) ENSMUSP00000019911 Mus musculus (house mouse) 79092 Nematostella vectensis (starlet anemone) XP_001600613.1 Nasonia vitripennis (wasp) ENSOANP00000005760 Ornithorynchus anatinus (platypus) ENSORLP00000022529 Oryzias latipes (japanese killifish) LOC_Os06g38470.1 Oryza sativa (asian rice) 27561 Ostreococcus tauri (green alga) PFI1260c Plasmodium falciparum (protozoal parasite) PHUM003084-PA Pediculus humanus (human body louse) PP28858 Pristionchus pacificus (nematode) 145029 Physcomitrella patens (moss) 199053 Physcomitrella patens (moss) ENSPPYP00000018964 Pongo pygmaeus (orangutan) 71132 Phytophthora ramorum (sudden oak death pathogen) 108792 Phytophthora sojae (root rot pathogen) 803954 Populus trichocarpa (black cottonwood) ENSPTRP00000049696 Pan troglodytes (chimpanzee) PVX_099700 Plasmodium vivax (protozoal parasite) ENSRNOP00000000742 Rattus norvegicus (norway rat) 4897718 Sorghum bicolor (sorghum) YNL330C Saccharomyces cerevisiae (budding yeast) Smp_005210 Schistosoma mansoni (trematode parasite) SPBC36.05c Schizosaccharomyces pombe (fission yeast) NP_999711.1 Strongylocentrotus purpuratus (purple sea urchin) 64072 Trichoplax adhaerens (metazoa) TA12690 Theileria annulata (apicomplexan parasite) XP_966633.1 Tribolium castaneum (red flour beetle) Tc00.1047053508637.114 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511911.159 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000020022 Tetraodon nigroviridis (green spotted pufferfish) TP02_0039 Theileria parva (parasitic protozoan) 41025 Thalassiosira pseudonana (marine diatom) ENSTRUP00000016628 Takifugu rubripes (pufferfish Takifugu) 3727.m00055 Tetrahymena thermophila (ciliate protozoa) 86485.m00643 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000011480 Xenopus tropicalis (frog) ENSXETP00000015978 Xenopus tropicalis (frog) YALI0E22935g Yarrowia lipolytica (nonconventional yeast) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /polycomb/rpd3-1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38565 modMine - Data generated by the modENCODE project. • FBgn0015805 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV18066 LH20273 LH17263 ISCW007830 FBgn0238719 FBgn0218597 FBgn0202705 FBgn0185553 FBgn0169594 JGI_V11_306940 FBgn0080373 FBgn0160525 FBgn0159598 FBgn0155513 FBgn0135499 FBgn0123162 FBgn0107493 FBgn0102077 CPIJ006836 BGIBMGA011747 ACYPI007884 ACYPI006180 ACYPI003204 ACYPI001259 GB14706 AGAP006511 AAEL004586 PB21115 PB21117 PHUM158460 GLEAN_02540
Synonyms & Secondary IDs ( 34 )
Reported As
Symbol Synonym	CG7471 (Aggarwal and Calvi, 2004, Foglietti et al., 2006, Haussmann et al., 2008, Chen et al., 2008, Ni et al., 2008, Spain et al., 2010, Reddy et al., 2010, Ni et al., 2010.12.1, Ni et al., 2011.7.19) dHDAC1 (Breiling et al., 2001, Huang and Kadonaga, 2001, Barlow et al., 2001, Bornemann et al., 2001, Tweedie et al., 1999, Johnson et al., 1998, Kim et al., 2007, Thompson and Travers, 2008, Crump et al., 2011, Kim et al., 2005) dHDAC-1 (Fritsch et al., 1999) DHDAC1 (Foglietti et al., 2006) dmHDA401 (Pandey et al., 2002) DmHDAC1 (Mottus et al., 1999) dRPD3 (Korenjak and Brehm, 2005, Eberharter and Becker, 2004, O'Connor and Simon, 1999, Tsukiyama and Wu, 1997, Taylor-Harding et al., 2004, Zhao et al., 2008, Murawska et al., 2008, Kunert et al., 2009, Lee et al., 2010) DRpd3 (Miotto et al., 2006) dRpd3 (Murawsky et al., 2001, Scharf et al., 2009) drpd3 (Canudas et al., 2005) E(var)3-64BC (Wallrath, 1998) HDAC (Guenther and Lazar, 2001, Saurin et al., 2001, Jones and Kadonaga, 2000, Padmanabhan et al., 2006) HDAC1 (Ng and Bird, 2000, Song et al., 2003, Song et al., 2004, Segal et al., 2004, Grewal and Elgin, 2002, Parsons et al., 2003, Chang et al., 2002, Bornemann et al., 2002, Huang, 2001, Bornemann et al., 2000, Mottus et al., 2000, Johnson, 1997.9.26, Grewal and Elgin, 2007, Wang and Brock, 2003, Biryukova and Heitzler, 2008, Qi et al., 2008, Biryukova and Heitzler, 2008, Czermin et al., 2001, Chen et al., 2008, Fiesel et al., 2010) Hdac1 (Zraly et al., 2004, Chang et al., 2001, Doheny et al., 2008, Lin et al., 2008, Zhang et al., 2008, Zhu et al., 2008) HDAC-1 (Lee et al., 1999) hdac1 (Canudas et al., 2005, Zhu et al., 2008) l(3)64Cc (Gepner et al., 1996, ) l(3)04556 (Singh et al., 2005, Maixner et al., 1998, ) Rpd3 (Cao et al., 2008, Nisha et al., 2008, Swaminathan and Pile, 2010, Holmes et al., 2006, Wang and Tsai, 2007, Chihara et al., 2007, Cho et al., 2005, Payankaulam et al., 2006, Machida et al., 2005, Moorman et al., 2006, Kohzaki and Murakami, 2005, Moorman et al., 2006, Parrish et al., 2006, Dallman et al., 2004, Tsai and Wang, 2007, Gan et al., 2010, Buszczak et al., 2007, Wang and Brock, 2003, Chihara et al., 2008, Biryukova and Heitzler, 2008, Longo and Kennedy, 2006, Liu and Lehmann, 2008, Zhao et al., 2008, Xing et al., 2007, Martinez and Arnosti, 2008, Latouche et al., 2007, González et al., 2008, Ayroles et al., 2009, Suzuki et al., 2009, Lee et al., 2009, Nie et al., 2009, Wang et al., 2008, Shi et al., 2006, Shirangi et al., 2006, Czermin et al., 2002, Branco et al., 2008, Pallos et al., 2008, Gim et al., 2001, Harbison et al., 2005, Chen et al., 2008, Morozova et al., 2006, Walrad et al., 2010, Winkler et al., 2010, Zhang et al., 2010, Tea et al., 2010, Huang et al., 2010, Burgio et al., 2008, Mourikis et al., 2010, Lorbeck et al., 2010, Walrad et al., 2011, Kong et al., 2010, Neumüller et al., 2011) RPD3 (Nusinow, 2005, Chopra and Mishra, 2005, Farkas et al., 2005, Farkas et al., 2003, Lehmann, 2004, Tie, 2002, Ballestar et al., 2001, Pile and Wassarman, 2000, Brehm et al., 2000, Wassarman and Pile, 2000, Spierer, 1996.11.6, Horard et al., 1999, Breiling et al., 1999, Maixner et al., 1998, Tsai et al., 1998, De Rubertis et al., 1996, Schwartz and Pirrotta, 2007, Doheny et al., 2008, Guarente, 2006, Tie et al., 2005, Stielow et al., 2008, Kurzhals et al., 2008, Rimkus et al., 2008, Pile et al., 2002, Tie et al., 2009, Marhold et al., 2004, van Steensel et al., 2010, Spain et al., 2010, Reddy et al., 2010, Filion et al., 2010) rpd3 (Rogina and Helfand, 2004, Bauer et al., 2004, Claycomb and Orr-Weaver, 2005, Pile et al., 2001, Rogina et al., 2002, Courey and Jia, 2001, Chen and Courey, 2000, Struffi and Arnosti, 2005, Lin et al., 2008, McClure and Schubiger, 2008, Reenan and Rogina, 2008, Moshkin et al., 2009, Zhang et al., 2010) Rpd3/HDAC (Kozlova and Thummel, 2000) rpd3 (Helfand and Rogina, 2003) Su(var)3-26 (Doheny et al., 2008) Su(var)326 (Peterson et al., 1994, Sinclair et al., 1983, ) Su(var)328 (Sinclair et al., 1983, )
Name Synonym	histone deacetylase (Kim et al., 2005) histone deacetylase 1 (Doheny et al., 2008) Histone Deacetylase 1 (Chihara et al., 2008) Histone Deacetylase-1 (Zhu et al., 2008) Histone Deacetylase 1 (HDAC1) (Chihara et al., 2007) reduced potassium dependency 3 (Lee et al., 2009) Rpd3 (Zhao et al., 2008, Xing et al., 2007, Wang et al., 2008, Branco et al., 2008) Rpd3 histone deacetylase (Payankaulam et al., 2006, Kohzaki and Murakami, 2005) Suppressor of variegation 326
Secondary FlyBase IDs
	FBgn0003632 FBgn0003634 FBgn0010843 FBgn0016893
References ( 237 )
Generate a list of	All references relating to this gene ( 237 )
List References by type	Research paper  ( 129 ) Supplementary material  ( 7 ) Review  ( 37 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 44 ) FlyBase analysis  ( 1 ) Book review  ( 1 ) DNA/RNA sequence record  ( 3 ) Computer file  ( 4 ) Protein sequence record  ( 1 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 ) Book  ( 1 )
Recent research papers ( 21 )
	Crump et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(19): 7814--7819 Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP. [FBrf0213668] Kirilly et al., 2011, Neuron 72(1): 86--100 Intrinsic epigenetic factors cooperate with the steroid hormone ecdysone to govern dendrite pruning in Drosophila. [FBrf0216319] Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Walrad et al., 2011, Mol. Biol. Cell 22(8): 1364--1374 Hairless is a cofactor for Runt-dependent transcriptional regulation. [FBrf0213441] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Fiesel et al., 2010, EMBO J. 29(1): 209--221 Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6. [FBrf0209628] Filion et al., 2010, Cell 143(2): 212--224 Systematic protein location mapping reveals five principal chromatin types in Drosophila cells. [FBrf0212051] Gan et al., 2010, Cell Res. 20(7): 763--783 Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq. [FBrf0211191] Huang et al., 2010, J. Cell Sci. 123(16): 2853--2861 Drosophila CAF-1 regulates HP1-mediated epigenetic silencing and pericentric heterochromatin stability. [FBrf0211452] Kong et al., 2010, Alcoholism, Clin. Exp. Res. 34(2): 302--316 Ethanol-regulated genes that contribute to ethanol sensitivity and rapid tolerance in Drosophila. [FBrf0209720] Lee et al., 2010, Mol. Cell. Biol. 30(10): 2563--2577 Drosophila RB proteins repress differentiation-specific genes via two different mechanisms. [FBrf0210656] Lorbeck et al., 2010, Gene 450(1-2): 8--17 The histone demethylase Dmel\Kdm4A controls genes required for life span and male-specific sex determination in Drosophila. [FBrf0209540] Mourikis et al., 2010, BMC Dev. Biol. 10: 107 Modifiers of notch transcriptional activity identified by genome-wide RNAi. [FBrf0212287] Reddy et al., 2010, Mol. Cell. Biol. 30(21): 5234--5244 Drosophila Transcription Factor Tramtrack69 Binds MEP1 To Recruit the Chromatin Remodeler NuRD. [FBrf0212010] Spain et al., 2010, J. Biol. Chem. 285(35): 27457--27467 Drosophila SIN3 isoforms interact with distinct proteins and have unique biological functions. [FBrf0211588] Swaminathan and Pile, 2010, Mech. Dev. 127(1-2): 96--106 Regulation of cell proliferation and wing development by Drosophila SIN3 and String. [FBrf0209854] Tea et al., 2010, J. Neurosci. 30(29): 9939--9946 Histone Deacetylase Rpd3 Regulates Olfactory Projection Neuron Dendrite Targeting via the Transcription Factor Prospero. [FBrf0211359] van Steensel et al., 2010, Genome Res. 20(2): 190--200 Bayesian network analysis of targeting interactions in chromatin. [FBrf0209848] Walrad et al., 2010, Mol. Biol. Cell 21(13): 2315--2326 Distinct contributions of conserved modules to runt transcription factor activity. [FBrf0211193] Winkler et al., 2010, PLoS ONE 5(4): e10166 Groucho-mediated repression may result from a histone deacetylase-dependent increase in nucleosome density. [FBrf0210549] Zhang et al., 2010, Genetics 184(4): 1165--1179 A genomewide RNA interference screen for modifiers of aggregates formation by mutant Huntingtin in Drosophila. [FBrf0210722] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...