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Gene Dmel\TfIIEβ

General Information
Symbol	Dmel\TfIIEβ	Species	D. melanogaster
Name	Transcription factor IIEβ	Annotation symbol	CG1276
Feature type	protein_coding_gene	FlyBase ID	FBgn0015829
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	TFIIE, TfIIEbeta
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	64A12-64A12	Sequence location	3L:4,287,038..4,288,349 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Transcription factor IIEβ is referred to in FlyBase by the symbol Dmel\TfIIEβ (CG1276, FBgn0015829). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: positive regulation of transcription from RNA polymerase II promoter; neurogenesis. 3 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Transcription factor TFIIE beta subunit, DNA-binding domain; Transcription initiation factor TFIIE, beta subunit; Winged helix-turn-helix transcription repressor DNA-binding. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system. Comments on Affy2 ProbeSet: ProbeSet 1634616_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of TfIIEbeta. Gene sequence location is 3L:4287038..4288349.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features BKN28221 HFA08701 Controlled Vocabulary Terms nucleus positive regulation of transcription from RNA polymerase II promoter
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 64A12-64A12   Limits computationally determined from genome sequence between P{PZ}l(3)rG166rG166 and P{PZ}sinu06524
Experimentally Determined Cytological Location
Cytogenetic map Notes References 64B-64B     (Wang, 1996.9.30) 64B-64B   (determined by in situ hybridisation)   (Wang et al., 1997)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\TfIIEβ for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) TfIIEβ-RA FBtr0073234  NM_079199   1049   292 TfIIEβ-RB FBtr0300449  NM_001169875   1121   249
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein TfIIEβ-PA   FBpp0073090   33.4   292   10.16     NP_523923   AAF47880 TfIIEβ-PB   FBpp0289677   28.5   249   9.84     NP_001163346   ACZ94618
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Winged helix-turn-helix transcription repressor DNA-binding (IPR011991) Transcription initiation factor TFIIE, beta subunit (IPR016656) Transcription factor TFIIE beta subunit, DNA-binding domain (IPR003166)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF47880   AE014296 ACZ94618   BT022197   BX063155   BX068258   BX068403   CO262810   CO296607   CO310268   CO316876   CO336156   EC068553   EC070649   EC070650   EC080339   EC080404   EC236574   EC238540   EC240813   EC247661   EC262303   U72893 AAD00188
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	O96881 E1JIC9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0015829    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0015829 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0015829 expression level Developmental Stage   Expression Level embryo 00-02hr    1604 embryo 02-04hr    2509 embryo 04-06hr    3537 embryo 06-08hr    2476 embryo 08-10hr    2200 embryo 10-12hr    1910 embryo 12-14hr    1492 embryo 14-16hr    990 embryo 16-18hr    831 embryo 18-20hr    946 embryo 20-22hr    805 embryo 22-24hr    917 larva L1    739 larva L2    744 larva L3 12hr old    500 larva L3 puffstage 1-2    766 larva L3 puffstage 3-6    1158 larva L3 puffstage 7-9    1434 white prepupae new    1379 white prepupae 12hr    1593 white prepupae 24hr    1612 pupae 2d postWPP    1376 pupae 3d postWPP    903 pupae 4d postWPP    649 adult male 01day    1081 adult male 05day    1209 adult male 30day    851 adult female 01day    782 adult female 05day    1188 adult female 30day    1127 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1604) embryo 02-04hr  (2509) embryo 04-06hr  (3537) embryo 06-08hr  (2476) embryo 08-10hr  (2200) embryo 10-12hr  (1910) embryo 12-14hr  (1492) embryo 14-16hr  (990) embryo 16-18hr  (831) embryo 18-20hr  (946) embryo 20-22hr  (805) embryo 22-24hr  (917) larva L1  (739) larva L2  (744) larva L3 12hr old  (500) larva L3 puffstage 1-2  (766) larva L3 puffstage 3-6  (1158) larva L3 puffstage 7-9  (1434) white prepupae new  (1379) white prepupae 12hr  (1593) white prepupae 24hr  (1612) pupae 2d postWPP  (1376) pupae 3d postWPP  (903) pupae 4d postWPP  (649) adult male 01day  (1081) adult male 05day  (1209) adult male 30day  (851) adult female 01day  (782) adult female 05day  (1188) adult female 30day  (1127) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (1604) embryo 02-04hr  (2509) embryo 04-06hr  (3537) embryo 06-08hr  (2476) embryo 08-10hr  (2200) embryo 10-12hr  (1910) embryo 12-14hr  1492 embryo 14-16hr    990 embryo 16-18hr    831 embryo 18-20hr    946 embryo 20-22hr    805 embryo 22-24hr    917 larva L1    739 larva L2    744 larva L3 12hr old    500 larva L3 puffstage 1-2    766 larva L3 puffstage 3-6    1158 larva L3 puffstage 7-9  1434 white prepupae new    1379 white prepupae 12hr  (1593) white prepupae 24hr  (1612) pupae 2d postWPP    1376 pupae 3d postWPP    903 pupae 4d postWPP    649 adult male 01day    1081 adult male 05day    1209 adult male 30day    851 adult female 01day    782 adult female 05day    1188 adult female 30day    1127 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1604 embryo 02-04hr    2509 embryo 04-06hr    3537 embryo 06-08hr    2476 embryo 08-10hr    2200 embryo 10-12hr    1910 embryo 12-14hr    1492 embryo 14-16hr    990 embryo 16-18hr    831 embryo 18-20hr    946 embryo 20-22hr    805 embryo 22-24hr    917 larva L1    739 larva L2    744 larva L3 12hr old    500 larva L3 puffstage 1-2    766 larva L3 puffstage 3-6    1158 larva L3 puffstage 7-9    1434 white prepupae new    1379 white prepupae 12hr    1593 white prepupae 24hr    1612 pupae 2d postWPP    1376 pupae 3d postWPP    903 pupae 4d postWPP    649 adult male 01day    1081 adult male 05day    1209 adult male 30day    851 adult female 01day    782 adult female 05day    1188 adult female 30day    1127 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1604 embryo 02-04hr    2509 embryo 04-06hr    3537 embryo 06-08hr    2476 embryo 08-10hr    2200 embryo 10-12hr    1910 embryo 12-14hr    1492 embryo 14-16hr    990 embryo 16-18hr    831 embryo 18-20hr    946 embryo 20-22hr    805 embryo 22-24hr    917 larva L1    739 larva L2    744 larva L3 12hr old    500 larva L3 puffstage 1-2    766 larva L3 puffstage 3-6    1158 larva L3 puffstage 7-9    1434 white prepupae new    1379 white prepupae 12hr    1593 white prepupae 24hr    1612 pupae 2d postWPP    1376 pupae 3d postWPP    903 pupae 4d postWPP    649 adult male 01day    1081 adult male 05day    1209 adult male 30day    851 adult female 01day    782 adult female 05day    1188 adult female 30day    1127 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0015829 expression level Developmental Stage   Expression Level embryo 00-02hr    1604 embryo 02-04hr    2509 embryo 04-06hr    3537 embryo 06-08hr    2476 embryo 08-10hr    2200 embryo 10-12hr    1910 embryo 12-14hr    1492 embryo 14-16hr    990 embryo 16-18hr    831 embryo 18-20hr    946 embryo 20-22hr    805 embryo 22-24hr    917 larva L1    739 larva L2    744 larva L3 12hr old    500 larva L3 puffstage 1-2    766 larva L3 puffstage 3-6    1158 larva L3 puffstage 7-9    1434 white prepupae new    1379 white prepupae 12hr    1593 white prepupae 24hr    1612 pupae 2d postWPP    1376 pupae 3d postWPP    903 pupae 4d postWPP    649 adult male 01day    1081 adult male 05day    1209 adult male 30day    851 adult female 01day    782 adult female 05day    1188 adult female 30day    1127 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1604) embryo 02-04hr  (2509) embryo 04-06hr  (3537) embryo 06-08hr  (2476) embryo 08-10hr  (2200) embryo 10-12hr  (1910) embryo 12-14hr  (1492) embryo 14-16hr  (990) embryo 16-18hr  (831) embryo 18-20hr  (946) embryo 20-22hr  (805) embryo 22-24hr  (917) larva L1  (739) larva L2  (744) larva L3 12hr old  (500) larva L3 puffstage 1-2  (766) larva L3 puffstage 3-6  (1158) larva L3 puffstage 7-9  (1434) white prepupae new  (1379) white prepupae 12hr  (1593) white prepupae 24hr  (1612) pupae 2d postWPP  (1376) pupae 3d postWPP  (903) pupae 4d postWPP  (649) adult male 01day  (1081) adult male 05day  (1209) adult male 30day  (851) adult female 01day  (782) adult female 05day  (1188) adult female 30day  (1127) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1604 embryo 02-04hr  (2509) embryo 04-06hr  (3537) embryo 06-08hr  (2476) embryo 08-10hr  2200 embryo 10-12hr  1910 embryo 12-14hr  1492 embryo 14-16hr    990 embryo 16-18hr    831 embryo 18-20hr    946 embryo 20-22hr    805 embryo 22-24hr    917 larva L1    739 larva L2    744 larva L3 12hr old    500 larva L3 puffstage 1-2    766 larva L3 puffstage 3-6    1158 larva L3 puffstage 7-9  1434 white prepupae new    1379 white prepupae 12hr  1593 white prepupae 24hr  1612 pupae 2d postWPP    1376 pupae 3d postWPP    903 pupae 4d postWPP    649 adult male 01day    1081 adult male 05day    1209 adult male 30day    851 adult female 01day    782 adult female 05day    1188 adult female 30day    1127 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1604 embryo 02-04hr    2509 embryo 04-06hr    3537 embryo 06-08hr    2476 embryo 08-10hr    2200 embryo 10-12hr    1910 embryo 12-14hr    1492 embryo 14-16hr    990 embryo 16-18hr    831 embryo 18-20hr    946 embryo 20-22hr    805 embryo 22-24hr    917 larva L1    739 larva L2    744 larva L3 12hr old    500 larva L3 puffstage 1-2    766 larva L3 puffstage 3-6    1158 larva L3 puffstage 7-9    1434 white prepupae new    1379 white prepupae 12hr    1593 white prepupae 24hr    1612 pupae 2d postWPP    1376 pupae 3d postWPP    903 pupae 4d postWPP    649 adult male 01day    1081 adult male 05day    1209 adult male 30day    851 adult female 01day    782 adult female 05day    1188 adult female 30day    1127 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1604 embryo 02-04hr    2509 embryo 04-06hr    3537 embryo 06-08hr    2476 embryo 08-10hr    2200 embryo 10-12hr    1910 embryo 12-14hr    1492 embryo 14-16hr    990 embryo 16-18hr    831 embryo 18-20hr    946 embryo 20-22hr    805 embryo 22-24hr    917 larva L1    739 larva L2    744 larva L3 12hr old    500 larva L3 puffstage 1-2    766 larva L3 puffstage 3-6    1158 larva L3 puffstage 7-9    1434 white prepupae new    1379 white prepupae 12hr    1593 white prepupae 24hr    1612 pupae 2d postWPP    1376 pupae 3d postWPP    903 pupae 4d postWPP    649 adult male 01day    1081 adult male 05day    1209 adult male 30day    851 adult female 01day    782 adult female 05day    1188 adult female 30day    1127 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0015829    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0015829 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0015829 expression level Tissue   Expression Level Larval Central Nervous System    187.525 Larval Midgut    54.9 Larval Hindgut    69.9 Larval Malpighian Tubules    119.3 Larval Fat Body    180.5 Larval Salivary Gland    123.9 Larval Trachea    103.6 Larval Carcass    62.2 Adult Head    119 Adult Eye    275.9 Adult Brain    144.7 Adult Thoracic-Abdominal Ganglion    154.8 Adult Crop    118.8 Adult Midgut    92.7 Adult Hindgut    97.2 Adult Malpighian Tubules    78.9 Adult Fat Body    100.1 Adult Salivary Gland    122.1 Adult Heart    111.125 Adult VirginFemale Spermatheca    144.6 Adult InseminatedFemale Spermatheca    136.9 Adult Ovary    151.8 Adult Testis    173.2 Adult Male Accessory Gland    110.9 Adult Carcass    87.1 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    187.525 Larval Midgut    54.9 Larval Hindgut    69.9 Larval Malpighian Tubules    119.3 Larval Fat Body    180.5 Larval Salivary Gland    123.9 Larval Trachea    103.6 Larval Carcass    62.2 Adult Head    119 Adult Eye    275.9 Adult Brain    144.7 Adult Thoracic-Abdominal Ganglion    154.8 Adult Crop    118.8 Adult Midgut    92.7 Adult Hindgut    97.2 Adult Malpighian Tubules    78.9 Adult Fat Body    100.1 Adult Salivary Gland    122.1 Adult Heart    111.125 Adult VirginFemale Spermatheca    144.6 Adult InseminatedFemale Spermatheca    136.9 Adult Ovary    151.8 Adult Testis    173.2 Adult Male Accessory Gland    110.9 Adult Carcass    87.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    187.525 Larval Midgut    54.9 Larval Hindgut    69.9 Larval Malpighian Tubules    119.3 Larval Fat Body    180.5 Larval Salivary Gland    123.9 Larval Trachea    103.6 Larval Carcass    62.2 Adult Head    119 Adult Eye    275.9 Adult Brain    144.7 Adult Thoracic-Abdominal Ganglion    154.8 Adult Crop    118.8 Adult Midgut    92.7 Adult Hindgut    97.2 Adult Malpighian Tubules    78.9 Adult Fat Body    100.1 Adult Salivary Gland    122.1 Adult Heart    111.125 Adult VirginFemale Spermatheca    144.6 Adult InseminatedFemale Spermatheca    136.9 Adult Ovary    151.8 Adult Testis    173.2 Adult Male Accessory Gland    110.9 Adult Carcass    87.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    187.525 Larval Midgut    54.9 Larval Hindgut    69.9 Larval Malpighian Tubules    119.3 Larval Fat Body    180.5 Larval Salivary Gland    123.9 Larval Trachea    103.6 Larval Carcass    62.2 Adult Head    119 Adult Eye    275.9 Adult Brain    144.7 Adult Thoracic-Abdominal Ganglion    154.8 Adult Crop    118.8 Adult Midgut    92.7 Adult Hindgut    97.2 Adult Malpighian Tubules    78.9 Adult Fat Body    100.1 Adult Salivary Gland    122.1 Adult Heart    111.125 Adult VirginFemale Spermatheca    144.6 Adult InseminatedFemale Spermatheca    136.9 Adult Ovary    151.8 Adult Testis    173.2 Adult Male Accessory Gland    110.9 Adult Carcass    87.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0015829 expression level Tissue   Expression Level Larval Central Nervous System    187.525 Larval Midgut    54.9 Larval Hindgut    69.9 Larval Malpighian Tubules    119.3 Larval Fat Body    180.5 Larval Salivary Gland    123.9 Larval Trachea    103.6 Larval Carcass    62.2 Adult Head    119 Adult Eye    275.9 Adult Brain    144.7 Adult Thoracic-Abdominal Ganglion    154.8 Adult Crop    118.8 Adult Midgut    92.7 Adult Hindgut    97.2 Adult Malpighian Tubules    78.9 Adult Fat Body    100.1 Adult Salivary Gland    122.1 Adult Heart    111.125 Adult VirginFemale Spermatheca    144.6 Adult InseminatedFemale Spermatheca    136.9 Adult Ovary    151.8 Adult Testis    173.2 Adult Male Accessory Gland    110.9 Adult Carcass    87.1 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    187.525 Larval Midgut    54.9 Larval Hindgut    69.9 Larval Malpighian Tubules    119.3 Larval Fat Body    180.5 Larval Salivary Gland    123.9 Larval Trachea    103.6 Larval Carcass    62.2 Adult Head    119 Adult Eye    275.9 Adult Brain    144.7 Adult Thoracic-Abdominal Ganglion    154.8 Adult Crop    118.8 Adult Midgut    92.7 Adult Hindgut    97.2 Adult Malpighian Tubules    78.9 Adult Fat Body    100.1 Adult Salivary Gland    122.1 Adult Heart    111.125 Adult VirginFemale Spermatheca    144.6 Adult InseminatedFemale Spermatheca    136.9 Adult Ovary    151.8 Adult Testis    173.2 Adult Male Accessory Gland    110.9 Adult Carcass    87.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    187.525 Larval Midgut    54.9 Larval Hindgut    69.9 Larval Malpighian Tubules    119.3 Larval Fat Body    180.5 Larval Salivary Gland    123.9 Larval Trachea    103.6 Larval Carcass    62.2 Adult Head    119 Adult Eye    275.9 Adult Brain    144.7 Adult Thoracic-Abdominal Ganglion    154.8 Adult Crop    118.8 Adult Midgut    92.7 Adult Hindgut    97.2 Adult Malpighian Tubules    78.9 Adult Fat Body    100.1 Adult Salivary Gland    122.1 Adult Heart    111.125 Adult VirginFemale Spermatheca    144.6 Adult InseminatedFemale Spermatheca    136.9 Adult Ovary    151.8 Adult Testis    173.2 Adult Male Accessory Gland    110.9 Adult Carcass    87.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    187.525 Larval Midgut    54.9 Larval Hindgut    69.9 Larval Malpighian Tubules    119.3 Larval Fat Body    180.5 Larval Salivary Gland    123.9 Larval Trachea    103.6 Larval Carcass    62.2 Adult Head    119 Adult Eye    275.9 Adult Brain    144.7 Adult Thoracic-Abdominal Ganglion    154.8 Adult Crop    118.8 Adult Midgut    92.7 Adult Hindgut    97.2 Adult Malpighian Tubules    78.9 Adult Fat Body    100.1 Adult Salivary Gland    122.1 Adult Heart    111.125 Adult VirginFemale Spermatheca    144.6 Adult InseminatedFemale Spermatheca    136.9 Adult Ovary    151.8 Adult Testis    173.2 Adult Male Accessory Gland    110.9 Adult Carcass    87.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    119   NA  Eye    275.9   NA  Brain    144.7   187.525  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    154.8   NA  Crop    118.8   54.9  Midgut    92.7   69.9  Hindgut    97.2   119.3  Malpighian Tubules    78.9   180.5  Fat Body    100.1   123.9  Salivary Gland    122.1   NA  Heart    111.125   103.6  Trachea    NA   NA  VirginFemale Spermatheca    144.6   NA  InseminatedFemale Spermatheca    136.9   NA  Ovary    151.8   NA  Testis    173.2   NA  Male Accessory Gland    110.9   62.2  Carcass    87.1 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_30
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015829 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1276-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL41407 TfIIEβGD6807 lethal, with Scer\GAL4pnr-MD237 TfIIEβGD6807 viable TfIIEβe00364 Sterility Allele fertile TfIIEβe00364 Other Phenotypes Allele neuroanatomy defective | larval stage, with Scer\GAL41407 TfIIEβGD6807 Phenotype manifest in Allele embryonic/larval neuroblast | larval stage, with Scer\GAL41407 TfIIEβGD6807 ganglion mother cell | larval stage, with Scer\GAL41407 TfIIEβGD6807
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of TfIIEβ Class Mutagen Stocks Known lesion TfIIEβe00364 piggyBac transposase 2 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of TfIIEβ Class Mutagen Stocks Known lesion TfIIEβGD6807 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes TfIIEβKK108221 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Exel8098 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{RB}TfIIEβe00364 NA
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
neurogenesis inferred from mutant phenotype (Neumüller et al., 2011) positive regulation of transcription from RNA polymerase II promoter inferred from direct assay (Wang et al., 1997)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Wang et al., 1997) transcription factor TFIIE complex inferred from physical interaction with TfIIEα (Wang et al., 1997)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
transcription initiation from RNA polymerase II promoter inferred from sequence or structural similarity with EMBL:Y08815 AND inferred from sequence or structural similarity with human GTF2E2 AND inferred from sequence or structural similarity with Saccharomyces TFA2 (Aoyagi and Wassarman, 2000)
Cellular Component
CV term Evidence References
transcription factor TFIIE complex inferred from sequence or structural similarity with EMBL:Y08815 AND inferred from sequence or structural similarity with human GTF2E2 AND inferred from sequence or structural similarity with Saccharomyces TFA2 (Aoyagi and Wassarman, 2000)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions TfIIEβ allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64004 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0015829 DroID - A comprehensive database of gene and protein interactions. • FBgn0015829 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38527
Orthologs
Genome-wide drosophilid orthologs	Dana\GF25060 Dere\GG15217 Dgri\GH15942 Dmoj\GI16593 Dper\GL17873 Dpse\GA11796 Dsec\GM14648 Dsim\GD13833 Dvir\GJ12845 Dwil\GK10558 Dyak\GE21436
Curated drosophilid orthologs	Dpse\GA11796
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL011462-PA Aedes aegypti (mosquito) AGAP005382-PA Anopheles gambiae (mosquito) XP_001120176.1 Apis mellifera (honey bee) XP_001946042.1 Acyrthosiphon pisum (pea aphid) At4g20330.1 Arabidopsis thaliana (wall cress) 116100 Branchiostoma floridae (lancelet) 276804 Branchiostoma floridae (lancelet) XP_001900792.1 Brugia malayi (roundworm nematode) BGIBMGA005878-PA Bombyx mori (silk worm) ENSBTAP00000016863 Bos taurus (bovine) CN10747 Caenorhabditis brenneri (small nematode) CBP34313 Caenorhabditis briggsae (nematode) CE26813 Caenorhabditis elegans (worm) ENSCAFP00000009719 Canis familiaris (dog) ENSCINP00000026391 Ciona intestinalis (sea squirt) JA07223 Caenorhabditis japonica (nematode) CML130C Cyanidioschyzon merolae (red alga) CPIJ013475 Culex pipens (mosquito) ENSCPOP00000007693 Cavia porcellus (guinea pig) RP09433 Caenorhabditis remanei (nematode) 218991 Capitella spl (polychaete worm) DDB0266450 Dictyostelium discoideum (amoeba) 206273 Daphnia pulex (daphnia) ENSDARP00000020885 Danio rerio (zebra fish) ENSECAP00000015641 Equus caballus (horse) ENSGACP00000020984 Gymnopilus aculeatus (mushroom) ENSGALP00000016708 Gallus gallus (chicken) 73187 Hypsipyla robusta (cedar shoot borer) ENSP00000348168 Homo sapiens (human) ISCW007887-PA Ixodes scapularis (deer tick) 127089 Lottia gigantea (owl limpet) ENSMODP00000023717 Monodelphis domestica (gray opossum) ENSMMUP00000000627 Macaca mulatta (rhesus monkey) ENSMUSP00000033993 Mus musculus (house mouse) 175862 Nematostella vectensis (starlet anemone) XP_001600678.1 Nasonia vitripennis (wasp) ENSOANP00000024922 Ornithorynchus anatinus (platypus) ENSORLP00000006075 Oryzias latipes (japanese killifish) LOC_Os10g25770.1 Oryza sativa (asian rice) PHUM004298-PA Pediculus humanus (human body louse) ENSPPYP00000020724 Pongo pygmaeus (orangutan) 640520 Populus trichocarpa (black cottonwood) ENSPTRP00000039088 Pan troglodytes (chimpanzee) ENSRNOP00000055659 Rattus norvegicus (norway rat) YKR062W Saccharomyces cerevisiae (budding yeast) Smp_079910 Schistosoma mansoni (trematode parasite) SPCC1672.08c Schizosaccharomyces pombe (fission yeast) XP_786458.2 Strongylocentrotus purpuratus (purple sea urchin) 54747 Trichoplax adhaerens (metazoa) XP_970060.2 Tribolium castaneum (red flour beetle) ENSTNIP00000007809 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000011832 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000024636 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB14966 NV18380 LH23941 ISCW007887 FBgn0238694 FBgn0212573 FBgn0200080 FBgn0185530 FBgn0169569 JGI_V11_206273 JGI_V11_210668 FBgn0071845 FBgn0155476 FBgn0139341 FBgn0123413 FBgn0107469 FBgn0102052 CPIJ013475 BGIBMGA005878 ACYPI003970 GB17636 AGAP005382 AAEL011462 PHUM501050 GLEAN_08709
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	17849 w1118; PBac{RB}TfIIEβe00364
Harvard	- PBac{RB}TfIIEβe00364
VDRC	v105735 P{KK108221}VIE-260B v17917 w1118; P{GD6807}v17917
Genomic Clones ( 1 )
	BACR39O11 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 15 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP01109
Other clones	DPiM_IP01109
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	81186 98470 162069 557060 CK01.7C.G6 CK01.26D.C10 CK01.30C.C12 CK01.102D.G3 EK086426 EK214417 EK220934 EK266074 EN11944
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0015829 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38527
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: TfIIEβ CG1276 (Gabrielian, 1999.11)
Source for database merge of
Additional comments
Other Comments
	TfIIE has been purified and shown to include two subunits. (Austin and Biggin, 1996) Kr dimers engage in protein-protein interaction with TfIIEβ (FBrf0082559). Kr monomer-dimer transition alters Krs ability to interact with the general transcription machinery (FBrf0082559). (Roberts and Green, 1995)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079199 NM_001169875 RefSeq (Proteins) • NP_523923 NP_001163346 DDBJ / EMBL / GenBank • AAD00188 AAF47880 ACZ94618 U72893 Entrez Gene - A searchable database of RefSeq genes. • 38527 UniProtKB/TrEMBL • E1JIC9 O96881
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Winged helix-turn-helix transcription repressor DNA-binding (IPR011991) Transcription initiation factor TFIIE, beta subunit (IPR016656) Transcription factor TFIIE beta subunit, DNA-binding domain (IPR003166)
Linkouts
	BioGRID - A database of protein and genetic interactions • 64004 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0015829 DroID - A comprehensive database of gene and protein interactions. • FBgn0015829 DRSC - Results from RNAi screens. • FBgn0015829 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015829 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1276-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0015829 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38527 InParanoid A subset of ortholog calls from InParanoid. • AAEL011462-PA Aedes aegypti (mosquito) AGAP005382-PA Anopheles gambiae (mosquito) XP_001120176.1 Apis mellifera (honey bee) XP_001946042.1 Acyrthosiphon pisum (pea aphid) At4g20330.1 Arabidopsis thaliana (wall cress) 116100 Branchiostoma floridae (lancelet) 276804 Branchiostoma floridae (lancelet) XP_001900792.1 Brugia malayi (roundworm nematode) BGIBMGA005878-PA Bombyx mori (silk worm) ENSBTAP00000016863 Bos taurus (bovine) CN10747 Caenorhabditis brenneri (small nematode) CBP34313 Caenorhabditis briggsae (nematode) CE26813 Caenorhabditis elegans (worm) ENSCAFP00000009719 Canis familiaris (dog) ENSCINP00000026391 Ciona intestinalis (sea squirt) JA07223 Caenorhabditis japonica (nematode) CML130C Cyanidioschyzon merolae (red alga) CPIJ013475 Culex pipens (mosquito) ENSCPOP00000007693 Cavia porcellus (guinea pig) RP09433 Caenorhabditis remanei (nematode) 218991 Capitella spl (polychaete worm) DDB0266450 Dictyostelium discoideum (amoeba) 206273 Daphnia pulex (daphnia) ENSDARP00000020885 Danio rerio (zebra fish) ENSECAP00000015641 Equus caballus (horse) ENSGACP00000020984 Gymnopilus aculeatus (mushroom) ENSGALP00000016708 Gallus gallus (chicken) 73187 Hypsipyla robusta (cedar shoot borer) ENSP00000348168 Homo sapiens (human) ISCW007887-PA Ixodes scapularis (deer tick) 127089 Lottia gigantea (owl limpet) ENSMODP00000023717 Monodelphis domestica (gray opossum) ENSMMUP00000000627 Macaca mulatta (rhesus monkey) ENSMUSP00000033993 Mus musculus (house mouse) 175862 Nematostella vectensis (starlet anemone) XP_001600678.1 Nasonia vitripennis (wasp) ENSOANP00000024922 Ornithorynchus anatinus (platypus) ENSORLP00000006075 Oryzias latipes (japanese killifish) LOC_Os10g25770.1 Oryza sativa (asian rice) PHUM004298-PA Pediculus humanus (human body louse) ENSPPYP00000020724 Pongo pygmaeus (orangutan) 640520 Populus trichocarpa (black cottonwood) ENSPTRP00000039088 Pan troglodytes (chimpanzee) ENSRNOP00000055659 Rattus norvegicus (norway rat) YKR062W Saccharomyces cerevisiae (budding yeast) Smp_079910 Schistosoma mansoni (trematode parasite) SPCC1672.08c Schizosaccharomyces pombe (fission yeast) XP_786458.2 Strongylocentrotus purpuratus (purple sea urchin) 54747 Trichoplax adhaerens (metazoa) XP_970060.2 Tribolium castaneum (red flour beetle) ENSTNIP00000007809 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000011832 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000024636 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38527 modMine - Data generated by the modENCODE project. • FBgn0015829 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB14966 NV18380 LH23941 ISCW007887 FBgn0238694 FBgn0212573 FBgn0200080 FBgn0185530 FBgn0169569 JGI_V11_206273 JGI_V11_210668 FBgn0071845 FBgn0155476 FBgn0139341 FBgn0123413 FBgn0107469 FBgn0102052 CPIJ013475 BGIBMGA005878 ACYPI003970 GB17636 AGAP005382 AAEL011462 PHUM501050 GLEAN_08709
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	CG1276 (Aoyagi and Wassarman, 2000, Keleman et al., 2009.8.5) dTFIIES (Wang, 1996.9.30) dTFIIE-S (Wang et al., 1997) ES (Park et al., 2001) TFIIE (Gu et al., 2002, Courey and Jia, 2001, Mizuguchi et al., 2001, Pham et al., 1999, Hansen et al., 1997, Sauer et al., 1995, Sauer et al., 1995, Wampler et al., 1990) TfIIE (Sauer et al., 1995) TfIIEbeta (Giot et al., 2003, Hoskins et al., 2005) TfIIEβ
Name Synonym	TFIIE small subunit (Kim and Lis, 2005) Transcription factor IIEβ (Roberts and Green, 1995, Hansen and Tjian, 1995, Sauer et al., 1995)
Secondary FlyBase IDs
References ( 30 )
Generate a list of	All references relating to this gene ( 30 )
List References by type	Research paper  ( 15 ) Supplementary material  ( 4 ) Review  ( 2 ) Personal communication to FlyBase  ( 4 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 2 ) Automatic genome annotation  ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2010 Show research papers ...
Recent reviews (0)
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