FB2020_06, released Dec 22, 2020

Gene: Dmel\Drip

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General Information
Symbol
Dmel\Drip
Species
D. melanogaster
Name
Drip
Annotation Symbol
CG9023
Feature Type
protein_coding_gene
FlyBase ID
FBgn0015872
Gene Model Status
Current
Stock Availability
10 publicly available
Gene Snapshot
Drip (Drip) encodes a protein that belongs to the MIP/aquaporin family involved in the transport of water across the cell membrane. In addition to its cellular roles, it has been implicated in regulating aspects of reproduction and aging. [Date last reviewed: 2019-03-07]
Other Summaries
Also Known As

aquaporin

Key Links
Genomic Location
Cytogenetic map
47F11-47F11
Sequence location
2R:11,411,203..11,429,645 [-]
Recombination map

2-64

RefSeq locus
NT_033778 REGION:11411203..11429645
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (8 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables water channel activity
inferred from direct assay
(Kaufmann et al., 2005)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables water channel activity
inferred from sequence or structural similarity with UniProtKB:P55088
(assigned by UniProt )
(UniProt Curators, 2002-)
inferred from biological aspect of ancestor with PANTHER:PTN002709492
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (5 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
involved_in regulation of oviposition
inferred from mutant phenotype
(Bergland et al., 2012)
involved_in renal system process
inferred from expression pattern
(Kaufmann et al., 2005)
involved_in transmembrane transport
inferred from direct assay
(Kaufmann et al., 2005)
involved_in water homeostasis
inferred from expression pattern
(Kaufmann et al., 2005)
involved_in water transport
inferred from direct assay
(Kaufmann et al., 2005)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in integral component of membrane
inferred from direct assay
(Kaufmann et al., 2005)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in integral component of membrane
inferred from biological aspect of ancestor with PANTHER:PTN002709492
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN002709492
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the MIP/aquaporin (TC 1.A.8) family. (Q9V5Z7)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
AQUAPORINS -
Aquaporins (AQPs) are integral membrane proteins with a central pore formed form two highly conserved hydrophobic regions, NPA boxes, which contain the signature Asp-Pro-Ala motif. They selectively allow the transfer of water across the membranes. (Adapted from PMID:22542572).
Protein Function (UniProtKB)
Forms a water-specific channel.
(UniProt, Q9V5Z7)
Gene Model and Products
Number of Transcripts
7
Number of Unique Polypeptides
6

Please see the JBrowse view of Dmel\Drip for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.44

Gene model reviewed during 5.49

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Drip-RA
FBtr0088141
NM_165833
1745
245
Drip-RB
FBtr0088142
NM_078973
1444
245
Drip-RC
FBtr0331387
NM_001273961
1514
243
Drip-RD
FBtr0331388
NM_001273962
1288
242
Drip-RE
FBtr0331389
NM_001273963
1180
239
Drip-RF
FBtr0331390
NM_001273964
1529
278
Drip-RG
FBtr0339488
NM_001299387
1351
233
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Drip-PA
FBpp0087240
25.6
245
6.91
NP_725051
AAM68740
Drip-PB
FBpp0087241
25.6
245
6.91
NP_523697
AAF58643
Drip-PC
FBpp0303805
25.4
243
6.91
NP_001260890
AGB93423
Drip-PD
FBpp0303806
25.2
242
6.91
NP_001260891
AGB93424
Drip-PE
FBpp0303807
24.9
239
7.45
NP_001260892
AGB93425
Drip-PF
FBpp0303808
29.3
278
8.28
NP_001260893
AGB93426
Drip-PG
FBpp0308570
24.1
233
8.33
NP_001286316
AHN56114
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

245 aa isoforms: Drip-PA, Drip-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Homotetramer.

(UniProt, Q9V5Z7)
Domain

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

(UniProt, Q9V5Z7)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Drip using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult Malpighian tubule Type II cell
(Denholm et al., 2013)
embryonic stage 5
organism | ubiquitous
(Kaufmann et al., 2005)
embryonic stage 8 -- 12
embryonic/larval gut
(Kaufmann et al., 2005)
embryonic stage 14
embryonic/larval gut | restricted
(Kaufmann et al., 2005)
embryonic/larval pharynx
(Kaufmann et al., 2005)
embryonic stage 17
posterior spiracle primordium
(Kaufmann et al., 2005)
Additional Descriptive Data

At embryonic stage 14, Drip expression demarcates the foregut-midgut border, where the proventriculus will form, and the midgut-hindgut border, where the Malpighian tubules will connect.

(Kaufmann et al., 2005)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
first instar larval stage
Malpighian tubule Type II cell
(Tapadia and Gautam, 2011)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in integral component of membrane
inferred from direct assay
(Kaufmann et al., 2005)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Drip in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 8 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Drip
Transgenic constructs containing regulatory region of Drip
Deletions and Duplications ( 0 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (16)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\AQP4
10 of 15
Yes
Yes
1  
Hsap\AQP2
8 of 15
No
Yes
Hsap\AQP5
8 of 15
No
Yes
Hsap\AQP1
7 of 15
No
Yes
Hsap\MIP
6 of 15
No
Yes
Hsap\AQP9
5 of 15
No
Yes
Hsap\AQP3
4 of 15
No
No
Hsap\AQP6
4 of 15
No
No
Hsap\AQP7
3 of 15
No
No
Hsap\AQP8
3 of 15
No
No
Hsap\AQP10
3 of 15
No
No
Hsap\G6PD
1 of 15
No
No
Hsap\LOC100509620
1 of 15
No
No
Hsap\MINDY4B
1 of 15
No
No
Hsap\SSTR5
1 of 15
No
No
Hsap\TRHR
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (11)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Aqp4
10 of 15
Yes
Yes
Mmus\Aqp2
9 of 15
No
Yes
Mmus\Aqp5
9 of 15
No
Yes
Mmus\Aqp1
7 of 15
No
No
Mmus\Mip
6 of 15
No
Yes
Mmus\Aqp6
5 of 15
No
No
Mmus\Aqp9
4 of 15
No
No
Mmus\Aqp3
3 of 15
No
No
Mmus\Aqp7
3 of 15
No
No
Mmus\Aqp8
3 of 15
No
No
Mmus\Mindy4
1 of 15
No
No
Rattus norvegicus (Norway rat) (10)
Rnor\Aqp2
7 of 13
Yes
Yes
Rnor\Aqp4
7 of 13
Yes
Yes
Rnor\Aqp5
7 of 13
Yes
Yes
Rnor\Aqp1
6 of 13
No
Yes
Rnor\Mip
6 of 13
No
Yes
Rnor\Aqp6
5 of 13
No
Yes
Rnor\Aqp3
3 of 13
No
No
Rnor\Aqp7
2 of 13
No
No
Rnor\Aqp8
2 of 13
No
No
Rnor\Aqp9
2 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (17)
Xtro\aqp2
8 of 12
Yes
Yes
Xtro\aqp5
5 of 12
No
Yes
Xtro\LOC100216133
5 of 12
No
Yes
Xtro\LOC100489792
5 of 12
No
Yes
Xtro\mip
5 of 12
No
Yes
Xtro\LOC100491830
4 of 12
No
Yes
Xtro\aqp4
3 of 12
No
Yes
Xtro\aqp9
3 of 12
No
No
Xtro\aqp1
2 of 12
No
No
Xtro\aqp3
2 of 12
No
No
Xtro\aqp8
2 of 12
No
Yes
Xtro\aqp10
2 of 12
No
No
Xtro\LOC100487834
2 of 12
No
Yes
Xtro\LOC101733960
2 of 12
No
Yes
Xtro\aqp7
1 of 12
No
No
Xtro\LOC100497434
1 of 12
No
Yes
Xtro\mindy4
1 of 12
No
No
Danio rerio (Zebrafish) (19)
Drer\aqp4
11 of 15
Yes
Yes
Drer\aqp1a.1
7 of 15
No
Yes
Drer\mipa
5 of 15
No
Yes
Drer\mipb
5 of 15
No
No
Drer\aqp1a.2
4 of 15
No
No
Drer\aqp3a
4 of 15
No
No
Drer\aqp3b
3 of 15
No
No
Drer\aqp8a.1
3 of 15
No
No
Drer\aqp8b
3 of 15
No
No
Drer\aqp9b
3 of 15
No
No
Drer\LOC101885864
3 of 15
No
No
Drer\aqp7
2 of 15
No
No
Drer\aqp8a.2
2 of 15
No
No
Drer\aqp10a
2 of 15
No
No
Drer\LOC110438841
2 of 15
No
Yes
Drer\aqp9a
1 of 15
No
Yes
Drer\aqp10b
1 of 15
No
No
Drer\mindy4b
1 of 15
No
No
Drer\si:dkey-30h22.11
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (9)
Cele\aqp-6
8 of 15
Yes
Yes
Cele\aqp-4
7 of 15
No
No
Cele\aqp-5
5 of 15
No
Yes
Cele\aqp-2
4 of 15
No
No
Cele\aqp-8
3 of 15
No
Yes
Cele\aqp-3
2 of 15
No
No
Cele\aqp-7
2 of 15
No
Yes
Cele\aqp-1
1 of 15
No
No
Cele\aqp-12
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (34)
Atha\BETA-TIP
6 of 9
Yes
Yes
Atha\DELTA-TIP
6 of 9
Yes
Yes
Atha\TIP3;1
6 of 9
Yes
Yes
Atha\GAMMA-TIP
5 of 9
No
Yes
Atha\PIP1;4
5 of 9
No
No
Atha\PIP1;5
5 of 9
No
No
Atha\PIP1A
5 of 9
No
No
Atha\PIP1B
5 of 9
No
No
Atha\PIP1C
5 of 9
No
No
Atha\PIP2;8
5 of 9
No
No
Atha\TIP1;3
5 of 9
No
Yes
Atha\TIP2;2
5 of 9
No
Yes
Atha\TIP2;3
5 of 9
No
Yes
Atha\TIP4;1
5 of 9
No
Yes
Atha\PIP2;4
4 of 9
No
No
Atha\PIP2;5
4 of 9
No
No
Atha\PIP2A
4 of 9
No
No
Atha\PIP2B
4 of 9
No
No
Atha\PIP2E
4 of 9
No
No
Atha\PIP3
4 of 9
No
No
Atha\RD28
4 of 9
No
No
Atha\TIP2
4 of 9
No
Yes
Atha\TIP5;1
4 of 9
No
Yes
Atha\NIP3;1
3 of 9
No
Yes
Atha\NIP4;1
3 of 9
No
Yes
Atha\NIP4;2
3 of 9
No
Yes
Atha\NLM1
3 of 9
No
Yes
Atha\NIP1;2
2 of 9
No
Yes
Atha\NIP2;1
2 of 9
No
Yes
Atha\NIP5;1
2 of 9
No
Yes
Atha\NIP7;1
2 of 9
No
Yes
Atha\AT1G52180
1 of 9
No
Yes
Atha\AT2G16835
1 of 9
No
Yes
Atha\AT2G29870
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (5)
Scer\AQY1
8 of 15
Yes
Yes
Scer\YLL053C
6 of 15
No
Yes
Scer\AQY2
3 of 15
No
Yes
Scer\AQY3
3 of 15
No
No
Scer\FPS1
2 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\SPAC977.17
3 of 12
Yes
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190FNI )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00002465
Drosophila simulans
Dsim\GD25901
Drosophila sechellia
Dsec\GM20426
Drosophila erecta
Dere\GG22646
Drosophila yakuba
Dyak\GE13520
Drosophila ananassae
Dana\GF12394
Drosophila pseudoobscura pseudoobscura
Dpse\GA24443
Drosophila persimilis
Dper\GL10680
Drosophila willistoni
Dwil\GK21884
Drosophila virilis
Dvir\GJ21971
Drosophila mojavensis
Dmoj\GI21049
Drosophila grimshawi
Dgri\GH20503
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150AHK )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17017852
Musca domestica
House fly
Mdoa\17017548
Glossina morsitans
Tsetse fly
Gmor\GMOY003126
Glossina morsitans
Tsetse fly
Gmor\GMOY012079
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_01298
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_06886
Mayetiola destructor
Hessian fly
Mdes\Mdes014181
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL003512
Anopheles darlingi
American malaria mosquito
Adar\ADAC002535
Anopheles gambiae
Malaria mosquito
Agam\AGAP008842
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ015705
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0EMX )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\aqp
Bombyx mori
Silkmoth
Bmor\BGIBMGA007675
Bombyx mori
Silkmoth
Bmor\BGIBMGA007757
Danaus plexippus
Monarch butterfly
Dple\DPOGS213057-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS202490-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS206965-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS204511-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS208660-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS213866-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL011747
Heliconius melpomene
Postman butterfly
Hmel\HMEL002342
Heliconius melpomene
Postman butterfly
Hmel\HMEL010331
Heliconius melpomene
Postman butterfly
Hmel\HMEL003610
Heliconius melpomene
Postman butterfly
Hmel\HMEL010333
Apis florea
Little honeybee
Aflo\2360506212
Apis florea
Little honeybee
Aflo\2360506132
Apis florea
Little honeybee
Aflo\2159461972
Apis florea
Little honeybee
Aflo\2147489457
Apis florea
Little honeybee
Aflo\2244282244
Apis mellifera
Western honey bee
Amel\GB52489
Apis mellifera
Western honey bee
Amel\GB41240
Apis mellifera
Western honey bee
Amel\GB41225
Apis mellifera
Western honey bee
Amel\GB43877
Apis mellifera
Western honey bee
Amel\GB43879
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP22393
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP23857
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP24004
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP22392
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP19593
Bombus terrestris
Buff-tailed bumblebee
Bter\15215274
Bombus terrestris
Buff-tailed bumblebee
Bter\15204141
Bombus terrestris
Buff-tailed bumblebee
Bter\15215277
Bombus terrestris
Buff-tailed bumblebee
Bter\15215067
Bombus terrestris
Buff-tailed bumblebee
Bter\15204140
Linepithema humile
Argentine ant
Lhum\LH20028
Linepithema humile
Argentine ant
Lhum\LH18880
Linepithema humile
Argentine ant
Lhum\LH22487
Linepithema humile
Argentine ant
Lhum\LH20033
Linepithema humile
Argentine ant
Lhum\LH18875
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00082e
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000b9a
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000b98
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG022094
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG009215
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG000852
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG000855
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG022098
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_08631
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_08469
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_08466
Tribolium castaneum
Red flour beetle
Tcas\TC014281
Tribolium castaneum
Red flour beetle
Tcas\TC014280
Tribolium castaneum
Red flour beetle
Tcas\TC031930
Tribolium castaneum
Red flour beetle
Tcas\TC001374
Tribolium castaneum
Red flour beetle
Tcas\TC033115
Tribolium castaneum
Red flour beetle
Tcas\TC011257
Tribolium castaneum
Red flour beetle
Tcas\TC014278
Pediculus humanus
Human body louse
Phum\PHUM434530
Pediculus humanus
Human body louse
Phum\PHUM369010
Pediculus humanus
Human body louse
Phum\PHUM195520
Pediculus humanus
Human body louse
Phum\PHUM474700
Rhodnius prolixus
Kissing bug
Rpro\RPRC008707
Rhodnius prolixus
Kissing bug
Rpro\RPRC002387
Rhodnius prolixus
Kissing bug
Rpro\RPRC002014
Rhodnius prolixus
Kissing bug
Rpro\RPRC003319
Rhodnius prolixus
Kissing bug
Rpro\RPRC003382
Cimex lectularius
Bed bug
Clec\CLEC007784
Cimex lectularius
Bed bug
Clec\CLEC025286
Cimex lectularius
Bed bug
Clec\CLEC025356
Cimex lectularius
Bed bug
Clec\CLEC013397
Acyrthosiphon pisum
Pea aphid
Apim\aqp1
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI072138
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI009194
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_14172
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_02773
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_00608
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0GX4 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR012412
Strigamia maritima
European centipede
Smar\SMAR001650
Strigamia maritima
European centipede
Smar\SMAR000320
Strigamia maritima
European centipede
Smar\SMAR007081
Strigamia maritima
European centipede
Smar\SMAR000309
Strigamia maritima
European centipede
Smar\SMAR003902
Strigamia maritima
European centipede
Smar\SMAR011145
Strigamia maritima
European centipede
Smar\SMAR000308
Strigamia maritima
European centipede
Smar\SMAR001775
Ixodes scapularis
Black-legged tick
Isca\ISCW021264
Ixodes scapularis
Black-legged tick
Isca\ISCW003955
Stegodyphus mimosarum
African social velvet spider
Smim\KFM64205.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM80420.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM80053.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur08g03620
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_199790
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G166T )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Aqp_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Aqp8_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hypp_2097
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Aqp8
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Aqp_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Aqp4
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Aqp1
Ciona intestinalis
Vase tunicate
Cint\LOC100175646
Ciona intestinalis
Vase tunicate
Cint\LOC100176371
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000009588
Ciona intestinalis
Vase tunicate
Cint\LOC100176808
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000002720
Gallus gallus
Domestic chicken
Ggal\AQP8
Gallus gallus
Domestic chicken
Ggal\AQP4
Gallus gallus
Domestic chicken
Ggal\AQP1
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000010260
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (7)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Eglp3
8 of 10
Eglp2
7 of 10
Eglp4
7 of 10
Prip
7 of 10
bib
6 of 10
Eglp1
6 of 10
CG14142
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 3 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    AQP4; aquaporin 4
    10 of 15
    600308
         
        AQP2; aquaporin 2
        8 of 15
        107777
        AQP5; aquaporin 5
        8 of 15
        600442
        AQP1; aquaporin 1 (Colton blood group)
        7 of 15
        107776
          MIP; major intrinsic protein of lens fiber
          6 of 15
          154050
          AQP9; aquaporin 9
          5 of 15
          602914
              AQP3; aquaporin 3 (Gill blood group)
              4 of 15
              600170
                AQP6; aquaporin 6
                4 of 15
                601383
                    AQP7; aquaporin 7
                    3 of 15
                    602974
                      AQP8; aquaporin 8
                      3 of 15
                      603750
                          AQP10; aquaporin 10
                          3 of 15
                          606578
                              Functional Complementation Data
                              Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                              Interactions
                              Summary of Physical Interactions
                              esyN Network Diagram
                              Interactions Browser
                              Summary of Genetic Interactions
                              esyN Network Diagram
                              Starting gene(s)
                              Interaction type
                              Interacting gene(s)
                              Reference
                              Starting gene(s)
                              Interaction type
                              Interacting gene(s)
                              Reference
                              External Data
                              Subunit Structure (UniProtKB)
                              Homotetramer.
                              (UniProt, Q9V5Z7 )
                              Linkouts
                              BioGRID - A database of protein and genetic interactions.
                              DroID - A comprehensive database of gene and protein interactions.
                              InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                              MIST (protein-protein) - An integrated Molecular Interaction Database
                              Pathways
                              Signaling Pathways (FlyBase)
                              Metabolic Pathways
                              External Data
                              Linkouts
                              Genomic Location and Detailed Mapping Data
                              Chromosome (arm)
                              2R
                              Recombination map

                              2-64

                              Cytogenetic map
                              47F11-47F11
                              Sequence location
                              2R:11,411,203..11,429,645 [-]
                              FlyBase Computed Cytological Location
                              Cytogenetic map
                              Evidence for location
                              47F11-47F11
                              Limits computationally determined from genome sequence between P{lacW}Tapδk17005&P{lacW}k05103 and P{lacW}l(2)k13403k13403&P{lacW}Egmk14708
                              Experimentally Determined Cytological Location
                              Cytogenetic map
                              Notes
                              References
                              47F-47F
                              (Dow, 1995.10.17)
                              48A-48A
                              (Drees et al., 1987)
                              Experimentally Determined Recombination Data
                              Location

                              2-64

                              (FlyBase, 2016)

                              2-64.4

                              (Comeron et al., 2012)

                              2-

                              (Dow, 1995.10.17, Drees et al., 1987)
                              Left of (cM)
                              Right of (cM)
                              Notes
                              Stocks and Reagents
                              Stocks (10)
                              Genomic Clones (27)
                              cDNA Clones (72)
                               

                              Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                              cDNA clones, fully sequenced
                              BDGP DGC clones
                              Other clones
                              Drosophila Genomics Resource Center cDNA clones

                              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                              cDNA Clones, End Sequenced (ESTs)
                              BDGP DGC clones
                              Other clones
                              RNAi and Array Information
                              Linkouts
                              DRSC - Results frm RNAi screens
                              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                              Antibody Information
                              Laboratory Generated Antibodies
                               

                              polyclonal

                              (Cabrero et al., 2020)
                              Commercially Available Antibodies
                               
                              Other Information
                              Relationship to Other Genes
                              Source for database identify of
                              Source for database merge of
                              Additional comments
                              Other Comments

                              Transcription unit defined during molecular analysis of the en-inv gene region.

                              (Drees et al., 1987)
                              Origin and Etymology
                              Discoverer
                              Etymology
                              Identification
                              External Crossreferences and Linkouts ( 59 )
                              Sequence Crossreferences
                              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                              Other crossreferences
                              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                              Flygut - An atlas of the Drosophila adult midgut
                              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                              InterPro - A database of protein families, domains and functional sites
                              KEGG Genes - Molecular building blocks of life in the genomic space.
                              modMine - A data warehouse for the modENCODE project
                              Linkouts
                              BioGRID - A database of protein and genetic interactions.
                              DPiM - Drosophila Protein interaction map
                              DroID - A comprehensive database of gene and protein interactions.
                              DRSC - Results frm RNAi screens
                              FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                              FlyMine - An integrated database for Drosophila genomics
                              InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                              MIST (protein-protein) - An integrated Molecular Interaction Database
                              Synonyms and Secondary IDs (10)
                              Datasets (0)
                              Study focus (0)
                              Experimental Role
                              Project
                              Project Type
                              Title
                              References (70)