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Gene Dmel\ast

General Information
Symbol	Dmel\ast	Species	D. melanogaster
Name	asteroid	Annotation symbol	CG4426
Feature type	protein_coding_gene	FlyBase ID	FBgn0015905
Gene Model Status	Current	Stock availability	22 publicly available
Also Known As	Sr, Star/asteroid
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	21E4-21E4	Sequence location	2L:1,077,980..1,080,809 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene asteroid is referred to in FlyBase by the symbol Dmel\ast (CG4426, FBgn0015905). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: larval somatic muscle development; epidermal growth factor receptor signaling pathway; compound eye photoreceptor fate commitment; imaginal disc-derived wing vein morphogenesis; imaginal disc-derived wing morphogenesis; compound eye morphogenesis. 35 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organ system subdivision; adult segment; thoracic segment; adult; hypodermal muscle of larval abdomen; external compound sense organ; region of integument; larval abdominal segment; embryonic/larval hypodermal muscle. It has one annotated transcript and one annotated polypeptide. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1631268_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of ast. Gene sequence location is 2L:1077980..1080809.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	ast: asteroid Eyes small and rough. Veins L2, L3, L4, and L5 do not always extend to margin. Overlaps wild type rarely. S +/+ ast has very small eyes with fused facets; veins L2 to L5 incomplete at tip. S ast/+ ast has slightly larger eye than S +/+ ast. S ast/+ + resembles S +/+ +. S +/+ ast and ast/ast partially suppress px and net. Eyes of ast/E(S) rough. RK2.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features HFA00803 BKN20620
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 21E4-21E4   Limits computationally determined from genome sequence between P{lacW}l(2)k09610k09610&P{lacW}Sk09538a and P{PZ}l(2)1068510685&P{lacW}Tango14k00619
Experimentally Determined Cytological Location
Cytogenetic map Notes References 21E1-21E2     (Kotarski, 1998.2.5) 21E2-21E2   (determined by in situ hybridisation)   (Higson et al., 1993)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)	S (Lewis, 1942, Lewis, 1945, Lewis, 1951)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\ast for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) ast-RA FBtr0077952  NM_078727   2719   854
Additional Transcript Data & Comments
Reported size (kB)	2.9 (northern blot) (Kotarski et al., 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein ast-PA   FBpp0077617   98.4   854   6.02     NP_523451   AAF51424
Additional Polypeptide Data & Comments
Reported size (kDa)	815 (aa); 93.5 (kD predicted) (Kotarski et al., 1998)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • No name available (IPR000513)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF51424   AF047010 AAC05483   AI109377   AI531506   AW944252   AY052070 AAK93494   BF489040   BF500022   BF500424   BF500458   BF505701   BF505757   BG634508   BG635394   BT044345   CO267652   CO314884   CO339216   EC084684   EC202971   EC255496
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VPW1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Kotarski et al., 1998) embryonic stage -- adult stage     (Kotarski et al., 1998) third instar larval stage   morphogenetic furrow | anterior to   (Kotarski et al., 1998)
Additional Descriptive Data
	ast transcript expression is high during embryonic and pupal stages. In the embryo, expression is restricted to proliferating tissues. (Kotarski et al., 1998)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0015905    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0015905 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0015905 expression level Developmental Stage   Expression Level embryo 00-02hr    1463 embryo 02-04hr    638 embryo 04-06hr    704 embryo 06-08hr    903 embryo 08-10hr    942 embryo 10-12hr    723 embryo 12-14hr    633 embryo 14-16hr    357 embryo 16-18hr    315 embryo 18-20hr    253 embryo 20-22hr    491 embryo 22-24hr    524 larva L1    854 larva L2    479 larva L3 12hr old    348 larva L3 puffstage 1-2    372 larva L3 puffstage 3-6    479 larva L3 puffstage 7-9    581 white prepupae new    522 white prepupae 12hr    655 white prepupae 24hr    829 pupae 2d postWPP    736 pupae 3d postWPP    485 pupae 4d postWPP    321 adult male 01day    565 adult male 05day    835 adult male 30day    758 adult female 01day    627 adult female 05day    1076 adult female 30day    1110 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1463) embryo 02-04hr  (638) embryo 04-06hr  (704) embryo 06-08hr  (903) embryo 08-10hr  (942) embryo 10-12hr  (723) embryo 12-14hr  (633) embryo 14-16hr  (357) embryo 16-18hr  (315) embryo 18-20hr  (253) embryo 20-22hr  (491) embryo 22-24hr  (524) larva L1  (854) larva L2  (479) larva L3 12hr old  (348) larva L3 puffstage 1-2  (372) larva L3 puffstage 3-6  (479) larva L3 puffstage 7-9  (581) white prepupae new  (522) white prepupae 12hr  (655) white prepupae 24hr  (829) pupae 2d postWPP  (736) pupae 3d postWPP  (485) pupae 4d postWPP  (321) adult male 01day  (565) adult male 05day  (835) adult male 30day  (758) adult female 01day  (627) adult female 05day  (1076) adult female 30day  (1110) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1463 embryo 02-04hr    638 embryo 04-06hr    704 embryo 06-08hr    903 embryo 08-10hr    942 embryo 10-12hr    723 embryo 12-14hr    633 embryo 14-16hr    357 embryo 16-18hr    315 embryo 18-20hr    253 embryo 20-22hr    491 embryo 22-24hr    524 larva L1    854 larva L2    479 larva L3 12hr old    348 larva L3 puffstage 1-2    372 larva L3 puffstage 3-6    479 larva L3 puffstage 7-9    581 white prepupae new    522 white prepupae 12hr    655 white prepupae 24hr    829 pupae 2d postWPP    736 pupae 3d postWPP    485 pupae 4d postWPP    321 adult male 01day    565 adult male 05day    835 adult male 30day    758 adult female 01day    627 adult female 05day    1076 adult female 30day    1110 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1463 embryo 02-04hr    638 embryo 04-06hr    704 embryo 06-08hr    903 embryo 08-10hr    942 embryo 10-12hr    723 embryo 12-14hr    633 embryo 14-16hr    357 embryo 16-18hr    315 embryo 18-20hr    253 embryo 20-22hr    491 embryo 22-24hr    524 larva L1    854 larva L2    479 larva L3 12hr old    348 larva L3 puffstage 1-2    372 larva L3 puffstage 3-6    479 larva L3 puffstage 7-9    581 white prepupae new    522 white prepupae 12hr    655 white prepupae 24hr    829 pupae 2d postWPP    736 pupae 3d postWPP    485 pupae 4d postWPP    321 adult male 01day    565 adult male 05day    835 adult male 30day    758 adult female 01day    627 adult female 05day    1076 adult female 30day    1110 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1463 embryo 02-04hr    638 embryo 04-06hr    704 embryo 06-08hr    903 embryo 08-10hr    942 embryo 10-12hr    723 embryo 12-14hr    633 embryo 14-16hr    357 embryo 16-18hr    315 embryo 18-20hr    253 embryo 20-22hr    491 embryo 22-24hr    524 larva L1    854 larva L2    479 larva L3 12hr old    348 larva L3 puffstage 1-2    372 larva L3 puffstage 3-6    479 larva L3 puffstage 7-9    581 white prepupae new    522 white prepupae 12hr    655 white prepupae 24hr    829 pupae 2d postWPP    736 pupae 3d postWPP    485 pupae 4d postWPP    321 adult male 01day    565 adult male 05day    835 adult male 30day    758 adult female 01day    627 adult female 05day    1076 adult female 30day    1110 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0015905 expression level Developmental Stage   Expression Level embryo 00-02hr    1463 embryo 02-04hr    638 embryo 04-06hr    704 embryo 06-08hr    903 embryo 08-10hr    942 embryo 10-12hr    723 embryo 12-14hr    633 embryo 14-16hr    357 embryo 16-18hr    315 embryo 18-20hr    253 embryo 20-22hr    491 embryo 22-24hr    524 larva L1    854 larva L2    479 larva L3 12hr old    348 larva L3 puffstage 1-2    372 larva L3 puffstage 3-6    479 larva L3 puffstage 7-9    581 white prepupae new    522 white prepupae 12hr    655 white prepupae 24hr    829 pupae 2d postWPP    736 pupae 3d postWPP    485 pupae 4d postWPP    321 adult male 01day    565 adult male 05day    835 adult male 30day    758 adult female 01day    627 adult female 05day    1076 adult female 30day    1110 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1463) embryo 02-04hr  (638) embryo 04-06hr  (704) embryo 06-08hr  (903) embryo 08-10hr  (942) embryo 10-12hr  (723) embryo 12-14hr  (633) embryo 14-16hr  (357) embryo 16-18hr  (315) embryo 18-20hr  (253) embryo 20-22hr  (491) embryo 22-24hr  (524) larva L1  (854) larva L2  (479) larva L3 12hr old  (348) larva L3 puffstage 1-2  (372) larva L3 puffstage 3-6  (479) larva L3 puffstage 7-9  (581) white prepupae new  (522) white prepupae 12hr  (655) white prepupae 24hr  (829) pupae 2d postWPP  (736) pupae 3d postWPP  (485) pupae 4d postWPP  (321) adult male 01day  (565) adult male 05day  (835) adult male 30day  (758) adult female 01day  (627) adult female 05day  (1076) adult female 30day  (1110) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1463 embryo 02-04hr    638 embryo 04-06hr    704 embryo 06-08hr    903 embryo 08-10hr    942 embryo 10-12hr    723 embryo 12-14hr    633 embryo 14-16hr    357 embryo 16-18hr    315 embryo 18-20hr    253 embryo 20-22hr    491 embryo 22-24hr    524 larva L1    854 larva L2    479 larva L3 12hr old    348 larva L3 puffstage 1-2    372 larva L3 puffstage 3-6    479 larva L3 puffstage 7-9    581 white prepupae new    522 white prepupae 12hr    655 white prepupae 24hr    829 pupae 2d postWPP    736 pupae 3d postWPP    485 pupae 4d postWPP    321 adult male 01day    565 adult male 05day    835 adult male 30day    758 adult female 01day    627 adult female 05day    1076 adult female 30day    1110 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1463 embryo 02-04hr    638 embryo 04-06hr    704 embryo 06-08hr    903 embryo 08-10hr    942 embryo 10-12hr    723 embryo 12-14hr    633 embryo 14-16hr    357 embryo 16-18hr    315 embryo 18-20hr    253 embryo 20-22hr    491 embryo 22-24hr    524 larva L1    854 larva L2    479 larva L3 12hr old    348 larva L3 puffstage 1-2    372 larva L3 puffstage 3-6    479 larva L3 puffstage 7-9    581 white prepupae new    522 white prepupae 12hr    655 white prepupae 24hr    829 pupae 2d postWPP    736 pupae 3d postWPP    485 pupae 4d postWPP    321 adult male 01day    565 adult male 05day    835 adult male 30day    758 adult female 01day    627 adult female 05day    1076 adult female 30day    1110 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1463 embryo 02-04hr    638 embryo 04-06hr    704 embryo 06-08hr    903 embryo 08-10hr    942 embryo 10-12hr    723 embryo 12-14hr    633 embryo 14-16hr    357 embryo 16-18hr    315 embryo 18-20hr    253 embryo 20-22hr    491 embryo 22-24hr    524 larva L1    854 larva L2    479 larva L3 12hr old    348 larva L3 puffstage 1-2    372 larva L3 puffstage 3-6    479 larva L3 puffstage 7-9    581 white prepupae new    522 white prepupae 12hr    655 white prepupae 24hr    829 pupae 2d postWPP    736 pupae 3d postWPP    485 pupae 4d postWPP    321 adult male 01day    565 adult male 05day    835 adult male 30day    758 adult female 01day    627 adult female 05day    1076 adult female 30day    1110 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0015905    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0015905 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0015905 expression level Tissue   Expression Level Larval Central Nervous System    56.575 Larval Midgut no informative data Larval Hindgut    34.4 Larval Malpighian Tubules    29.3 Larval Fat Body no informative data Larval Salivary Gland    53.2 Larval Trachea    40.325 Larval Carcass    37.825 Adult Head    23.1 Adult Eye    16.875 Adult Brain    29.2 Adult Thoracic-Abdominal Ganglion    21.4 Adult Crop    41.2 Adult Midgut    42.4 Adult Hindgut    34.8 Adult Malpighian Tubules    24.3 Adult Fat Body    33.1 Adult Salivary Gland    37.6 Adult Heart    15.275 Adult VirginFemale Spermatheca    24.1 Adult InseminatedFemale Spermatheca    37.4 Adult Ovary    112.4 Adult Testis    85.5 Adult Male Accessory Gland    56.3 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    56.575 Larval Midgut no informative data Larval Hindgut    34.4 Larval Malpighian Tubules    29.3 Larval Fat Body no informative data Larval Salivary Gland    53.2 Larval Trachea    40.325 Larval Carcass    37.825 Adult Head    23.1 Adult Eye    16.875 Adult Brain    29.2 Adult Thoracic-Abdominal Ganglion    21.4 Adult Crop    41.2 Adult Midgut    42.4 Adult Hindgut    34.8 Adult Malpighian Tubules    24.3 Adult Fat Body    33.1 Adult Salivary Gland    37.6 Adult Heart    15.275 Adult VirginFemale Spermatheca    24.1 Adult InseminatedFemale Spermatheca    37.4 Adult Ovary    112.4 Adult Testis    85.5 Adult Male Accessory Gland    56.3 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    56.575 Larval Midgut no informative data Larval Hindgut    34.4 Larval Malpighian Tubules    29.3 Larval Fat Body no informative data Larval Salivary Gland    53.2 Larval Trachea    40.325 Larval Carcass    37.825 Adult Head    23.1 Adult Eye    16.875 Adult Brain    29.2 Adult Thoracic-Abdominal Ganglion    21.4 Adult Crop    41.2 Adult Midgut    42.4 Adult Hindgut    34.8 Adult Malpighian Tubules    24.3 Adult Fat Body    33.1 Adult Salivary Gland    37.6 Adult Heart    15.275 Adult VirginFemale Spermatheca    24.1 Adult InseminatedFemale Spermatheca    37.4 Adult Ovary    112.4 Adult Testis    85.5 Adult Male Accessory Gland    56.3 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    56.575 Larval Midgut no informative data Larval Hindgut    34.4 Larval Malpighian Tubules    29.3 Larval Fat Body no informative data Larval Salivary Gland    53.2 Larval Trachea    40.325 Larval Carcass    37.825 Adult Head    23.1 Adult Eye    16.875 Adult Brain    29.2 Adult Thoracic-Abdominal Ganglion    21.4 Adult Crop    41.2 Adult Midgut    42.4 Adult Hindgut    34.8 Adult Malpighian Tubules    24.3 Adult Fat Body    33.1 Adult Salivary Gland    37.6 Adult Heart    15.275 Adult VirginFemale Spermatheca    24.1 Adult InseminatedFemale Spermatheca    37.4 Adult Ovary    112.4 Adult Testis    85.5 Adult Male Accessory Gland    56.3 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0015905 expression level Tissue   Expression Level Larval Central Nervous System    56.575 Larval Midgut no informative data Larval Hindgut    34.4 Larval Malpighian Tubules    29.3 Larval Fat Body no informative data Larval Salivary Gland    53.2 Larval Trachea    40.325 Larval Carcass    37.825 Adult Head    23.1 Adult Eye    16.875 Adult Brain    29.2 Adult Thoracic-Abdominal Ganglion    21.4 Adult Crop    41.2 Adult Midgut    42.4 Adult Hindgut    34.8 Adult Malpighian Tubules    24.3 Adult Fat Body    33.1 Adult Salivary Gland    37.6 Adult Heart    15.275 Adult VirginFemale Spermatheca    24.1 Adult InseminatedFemale Spermatheca    37.4 Adult Ovary    112.4 Adult Testis    85.5 Adult Male Accessory Gland    56.3 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    56.575 Larval Midgut no informative data Larval Hindgut    34.4 Larval Malpighian Tubules    29.3 Larval Fat Body no informative data Larval Salivary Gland    53.2 Larval Trachea    40.325 Larval Carcass    37.825 Adult Head    23.1 Adult Eye    16.875 Adult Brain    29.2 Adult Thoracic-Abdominal Ganglion    21.4 Adult Crop    41.2 Adult Midgut    42.4 Adult Hindgut    34.8 Adult Malpighian Tubules    24.3 Adult Fat Body    33.1 Adult Salivary Gland    37.6 Adult Heart    15.275 Adult VirginFemale Spermatheca    24.1 Adult InseminatedFemale Spermatheca    37.4 Adult Ovary    112.4 Adult Testis    85.5 Adult Male Accessory Gland    56.3 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    56.575 Larval Midgut no informative data Larval Hindgut    34.4 Larval Malpighian Tubules    29.3 Larval Fat Body no informative data Larval Salivary Gland    53.2 Larval Trachea    40.325 Larval Carcass    37.825 Adult Head    23.1 Adult Eye    16.875 Adult Brain    29.2 Adult Thoracic-Abdominal Ganglion    21.4 Adult Crop    41.2 Adult Midgut    42.4 Adult Hindgut    34.8 Adult Malpighian Tubules    24.3 Adult Fat Body    33.1 Adult Salivary Gland    37.6 Adult Heart    15.275 Adult VirginFemale Spermatheca    24.1 Adult InseminatedFemale Spermatheca    37.4 Adult Ovary    112.4 Adult Testis    85.5 Adult Male Accessory Gland    56.3 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    56.575 Larval Midgut no informative data Larval Hindgut    34.4 Larval Malpighian Tubules    29.3 Larval Fat Body no informative data Larval Salivary Gland    53.2 Larval Trachea    40.325 Larval Carcass    37.825 Adult Head    23.1 Adult Eye    16.875 Adult Brain    29.2 Adult Thoracic-Abdominal Ganglion    21.4 Adult Crop    41.2 Adult Midgut    42.4 Adult Hindgut    34.8 Adult Malpighian Tubules    24.3 Adult Fat Body    33.1 Adult Salivary Gland    37.6 Adult Heart    15.275 Adult VirginFemale Spermatheca    24.1 Adult InseminatedFemale Spermatheca    37.4 Adult Ovary    112.4 Adult Testis    85.5 Adult Male Accessory Gland    56.3 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    23.1   NA  Eye    16.875   NA  Brain    29.2   56.575  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    21.4   NA  Crop    41.2   no informative data  Midgut    42.4   34.4  Hindgut    34.8   29.3  Malpighian Tubules    24.3   no informative data  Fat Body    33.1   53.2  Salivary Gland    37.6   NA  Heart    15.275   40.325  Trachea    NA   NA  VirginFemale Spermatheca    24.1   NA  InseminatedFemale Spermatheca    37.4   NA  Ovary    112.4   NA  Testis    85.5   NA  Male Accessory Gland    56.3   37.825  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_06
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015905 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4426-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | recessive astrv1 astrv3 viable ast2 ast3 viable, with Scer\GAL4pnr-MD237 astGD1376 Sterility Allele female sterile | recessive ast2 Other Phenotypes Allele visible (with ast1) astB612 astK2 astK3 astK5 astK6 astK7 astK9 astK11 astK12 astK13 astK14 astK15 astK16 astK17 astK18 astK19 astK20 astK21 visible (with astB612) ast1 visible (with astK2) ast1 visible (with astK3) ast1 visible (with astK5) ast1 visible (with astK6) ast1 visible (with astK7) ast1 visible (with astK9) ast1 visible (with astK11) ast1 visible (with astK12) ast1 visible (with astK13) ast1 visible (with astK14) ast1 visible (with astK15) ast1 visible (with astK16) ast1 visible (with astK17) ast1 visible (with astK18) ast1 visible (with astK19) ast1 visible (with astK20) ast1 visible (with astK21) ast1 visible | dominant astKG07563 visible | partially | recessive ast1 visible | recessive ast1 ast2 ast3 wild-type astrv1 wild-type (with ast1) astrv1 wild-type (with ast3) astrv1 wild-type (with ast4) astrv1 wild-type (with astrv1) ast1 ast3 ast4 astrv2 wild-type (with astrv2) astrv1 wild-type (with T(2;4)astv) astrv1 Phenotype manifest in Allele A1-7 dorsal oblique muscle 4 (with Df(2L)ast4) ast1 A1-7 lateral longitudinal muscle 1 (with Df(2L)ast4) ast1 embryonic somatic muscle (with Df(2L)ast4) ast1 eye ast1 ast2 ast3 ast4 ommatidium ast1 ast2 ast3 ast4 ommatidium (with ast1) astB612 astK11 astK12 astK13 astK14 astK15 astK16 astK17 astK18 astK19 astK2 astK20 astK21 astK3 astK5 astK6 astK7 astK9 ommatidium (with astB612) ast1 ommatidium (with astK2) ast1 ommatidium (with astK3) ast1 ommatidium (with astK5) ast1 ommatidium (with astK6) ast1 ommatidium (with astK7) ast1 ommatidium (with astK9) ast1 ommatidium (with astK11) ast1 ommatidium (with astK12) ast1 ommatidium (with astK13) ast1 ommatidium (with astK14) ast1 ommatidium (with astK15) ast1 ommatidium (with astK16) ast1 ommatidium (with astK17) ast1 ommatidium (with astK18) ast1 ommatidium (with astK19) ast1 ommatidium (with astK20) ast1 ommatidium (with astK21) ast1 wing astKG07563 wing vein ast1 wing vein | ectopic astKG07563 wing vein L2 ast1 wing vein L2 (with ast1) astB612 astK12 astK13 astK14 astK15 astK16 astK17 astK18 astK19 astK2 astK21 astK3 astK5 astK7 astK9 wing vein L2 (with astB612) ast1 wing vein L2 (with astK2) ast1 wing vein L2 (with astK3) ast1 wing vein L2 (with astK5) ast1 wing vein L2 (with astK7) ast1 wing vein L2 (with astK9) ast1 wing vein L2 (with astK12) ast1 wing vein L2 (with astK13) ast1 wing vein L2 (with astK14) ast1 wing vein L2 (with astK15) ast1 wing vein L2 (with astK16) ast1 wing vein L2 (with astK17) ast1 wing vein L2 (with astK18) ast1 wing vein L2 (with astK19) ast1 wing vein L2 (with astK21) ast1 wing vein L3 ast1 wing vein L3 (with ast1) astB612 astK12 astK13 astK14 astK15 astK16 astK17 astK18 astK19 astK2 astK21 astK3 astK5 astK7 astK9 wing vein L3 (with astB612) ast1 wing vein L3 (with astK2) ast1 wing vein L3 (with astK3) ast1 wing vein L3 (with astK5) ast1 wing vein L3 (with astK7) ast1 wing vein L3 (with astK9) ast1 wing vein L3 (with astK12) ast1 wing vein L3 (with astK13) ast1 wing vein L3 (with astK14) ast1 wing vein L3 (with astK15) ast1 wing vein L3 (with astK16) ast1 wing vein L3 (with astK17) ast1 wing vein L3 (with astK18) ast1 wing vein L3 (with astK19) ast1 wing vein L3 (with astK21) ast1 wing vein L4 ast1 wing vein L4 (with ast1) astB612 astK12 astK13 astK14 astK15 astK16 astK17 astK18 astK19 astK2 astK21 astK3 astK5 astK7 astK9 wing vein L4 (with astB612) ast1 wing vein L4 (with astK2) ast1 wing vein L4 (with astK3) ast1 wing vein L4 (with astK5) ast1 wing vein L4 (with astK7) ast1 wing vein L4 (with astK9) ast1 wing vein L4 (with astK12) ast1 wing vein L4 (with astK13) ast1 wing vein L4 (with astK14) ast1 wing vein L4 (with astK15) ast1 wing vein L4 (with astK16) ast1 wing vein L4 (with astK17) ast1 wing vein L4 (with astK18) ast1 wing vein L4 (with astK19) ast1 wing vein L4 (with astK21) ast1 wing vein L5 ast1 wing vein L5 (with ast1) astB612 astK12 astK13 astK14 astK15 astK16 astK17 astK18 astK19 astK2 astK21 astK3 astK5 astK7 astK9 wing vein L5 (with astB612) ast1 wing vein L5 (with astK2) ast1 wing vein L5 (with astK3) ast1 wing vein L5 (with astK5) ast1 wing vein L5 (with astK7) ast1 wing vein L5 (with astK9) ast1 wing vein L5 (with astK12) ast1 wing vein L5 (with astK13) ast1 wing vein L5 (with astK14) ast1 wing vein L5 (with astK15) ast1 wing vein L5 (with astK16) ast1 wing vein L5 (with astK17) ast1 wing vein L5 (with astK18) ast1 wing vein L5 (with astK19) ast1 wing vein L5 (with astK21) ast1
Classical Alleles ( 33 )
For All Classical Alleles Show
Allele of ast Class Mutagen Stocks Known lesion ast1 spontaneous 12 Yes astX X ray 4 -- ast4 spontaneous 3 -- ast3 spontaneous 2 -- astKG07563 1 -- ast2 spontaneous 0 -- ast5 spontaneous 0 -- astB612 hypomorphic allele - genetic evidence Delta2-3 0 Yes astK11 hypomorphic allele - genetic evidence Delta2-3 0 -- astK12 hypomorphic allele - genetic evidence Delta2-3 0 Yes astK13 hypomorphic allele - genetic evidence Delta2-3 0 -- astK14 hypomorphic allele - genetic evidence Delta2-3 0 -- astK15 hypomorphic allele - genetic evidence Delta2-3 0 -- astK16 hypomorphic allele - genetic evidence Delta2-3 0 -- astK17 hypomorphic allele - genetic evidence Delta2-3 0 -- astK18 hypomorphic allele - genetic evidence Delta2-3 0 -- astK19 hypomorphic allele - genetic evidence Delta2-3 0 -- astK20 hypomorphic allele - genetic evidence Delta2-3 0 Yes astK21 hypomorphic allele - genetic evidence Delta2-3 0 -- astK2 hypomorphic allele - genetic evidence Delta2-3 0 -- astK3 hypomorphic allele - genetic evidence Delta2-3 0 Yes astK5 hypomorphic allele - genetic evidence Delta2-3 0 -- astK6 hypomorphic allele - genetic evidence Delta2-3 0 Yes astK6e3 Delta2-3 0 -- astK6r6 Delta2-3 0 Yes astK6r7 Delta2-3 0 -- astK7 hypomorphic allele - genetic evidence Delta2-3 0 -- astK9 hypomorphic allele - genetic evidence Delta2-3 0 Yes astR1 gamma ray 0 -- astrv1 X ray 0 -- astrv2 X ray 0 -- astrv3 X ray 0 -- astunspecified 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of ast Class Mutagen Stocks Known lesion astGD1376 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes astKK100524 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)ast1 (Roberts et al., 1985) Df(2L)ast2 (Roberts et al., 1985, Kolodkin et al., 1994) Df(2L)ast3 (Roberts et al., 1985) Df(2L)ast4 (Roberts et al., 1985) Df(2L)ast5 (Roberts et al., 1985) Df(2L)ast6 (Roberts et al., 1985) Df(2L)ast10 (Roberts et al., 1985) Df(2L)Exel6004 (Ryder, 2004.4.26) Df(2L)Exel9037 (Ryder, 2004.4.26) Df(2L)S1 (Lewis, 1945) Df(2L)S2 (Roberts et al., 1985, Lewis, 1945) Df(2L)S3 (Roberts et al., 1985, Lewis, 1945) Df(2L)S4 (Lewis, 1945) Df(2L)S5 (Lewis, 1945) In(2L)ast-1 (Roberts et al., 1985)
Duplicated in	Dp(2;2)S (Lewis, 1945)
Not disrupted in	In(2L)dppho40 (Lewis, 1945) T(Y;2)21E (Lewis, 1945)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1376} NA P{KK100524} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{}astB612 NA P{}astK2 NA P{}astK3 NA P{}astK5 NA P{}astK6 NA P{}astK7 NA P{}astK9 NA P{}astK11 NA P{}astK12 NA P{}astK13 NA P{}astK14 NA P{}astK15 NA P{}astK16 NA P{}astK17 NA P{}astK18 NA P{}astK19 NA P{}astK20 NA P{}astK21 NA P{SUPor-P}astKG07563 NA insertion of mobile activating element P{EP}SEP2472 NA insertion of enhancer trap P{lacW}Sk06921 No
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
	There is no information supporting a cellular component or molecular function term for this gene. (Based on a review of available data on: 2006-10-26)
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
compound eye morphogenesis inferred from mutant phenotype (Lewis, 1945) compound eye photoreceptor fate commitment inferred from genetic interaction with Sos (Kolodkin et al., 1994) inferred from mutant phenotype (assigned by UniProtKB) (Kotarski et al., 1998) epidermal growth factor receptor signaling pathway inferred from genetic interaction with Egfr (Kolodkin et al., 1994) inferred from mutant phenotype (assigned by UniProtKB) (Kotarski et al., 1998) imaginal disc-derived wing morphogenesis inferred from mutant phenotype (Dworkin and Gibson, 2006) imaginal disc-derived wing vein morphogenesis inferred from mutant phenotype (Lewis, 1945) larval somatic muscle development inferred from mutant phenotype (Artero et al., 2003)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions ast allele Gene References ast1 E(S) (Lewis, 1945) net (Lewis, 1945) px (Lewis, 1945) rux (Thomas et al., 1994) S (Lewis, 1945, Meyer, 1952) ast2 E(S) (Lewis, 1945) S (Lewis, 1945) ast3 E(S) (Lewis, 1945) S (Lewis, 1945) ast4 E(S) (Lewis, 1945) S (Lewis, 1945) astK6 Egfr (Kotarski et al., 1998) S (Kotarski et al., 1998) astunspecified Egfr (Diaz-Benjumea and Garcia-Bellido, 1990) S (Kolodkin et al., 1994) unspecified E(S)   net   px   S (Lewis, 1945)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59535 DroID - A comprehensive database of gene and protein interactions. • FBgn0015905 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33282
Orthologs
Genome-wide drosophilid orthologs	Dana\GF15158 Dere\GG24761 Dgri\GH13686 Dmoj\GI17970 Dper\GL15474 Dpse\GA18175 Dsec\GM16785 Dsim\GD23065 Dvir\GJ16310 Dwil\GK24697 Dyak\GE17276
Curated drosophilid orthologs	Dpse\GA18175
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL007237-PA Aedes aegypti (mosquito) AGAP009607-PA Anopheles gambiae (mosquito) XP_625006.2 Apis mellifera (honey bee) XP_001946426.1 Acyrthosiphon pisum (pea aphid) 218990 Branchiostoma floridae (lancelet) BGIBMGA006129-PA Bombyx mori (silk worm) ENSBTAP00000031777 Bos taurus (bovine) ENSCAFP00000009160 Canis familiaris (dog) ENSCINP00000006981 Ciona intestinalis (sea squirt) cn10150 Cryptococcus neoformans (yeast-like fungus) CPIJ004348 Culex pipens (mosquito) ENSCPOP00000005122 Cavia porcellus (guinea pig) 34308 Capitella spl (polychaete worm) 324622 Daphnia pulex (daphnia) ENSDARP00000084981 Danio rerio (zebra fish) ENSECAP00000011775 Equus caballus (horse) ENSGACP00000008011 Gymnopilus aculeatus (mushroom) ENSGALP00000008299 Gallus gallus (chicken) 132438 Hypsipyla robusta (cedar shoot borer) ENSP00000264992 Homo sapiens (human) ISCW000775-PA Ixodes scapularis (deer tick) 122662 Lottia gigantea (owl limpet) ENSMODP00000014935 Monodelphis domestica (gray opossum) ENSMMUP00000038439 Macaca mulatta (rhesus monkey) ENSMUSP00000035181 Mus musculus (house mouse) 223271 Nematostella vectensis (starlet anemone) XP_001600677.1 Nasonia vitripennis (wasp) ENSOANP00000010799 Ornithorynchus anatinus (platypus) ENSORLP00000004702 Oryzias latipes (japanese killifish) PHUM008656-PA Pediculus humanus (human body louse) ENSPPYP00000015774 Pongo pygmaeus (orangutan) ENSPTRP00000026524 Pan troglodytes (chimpanzee) ENSRNOP00000017743 Rattus norvegicus (norway rat) Smp_080620 Schistosoma mansoni (trematode parasite) XP_001192581.1 Strongylocentrotus purpuratus (purple sea urchin) 57734 Trichoplax adhaerens (metazoa) XP_975212.1 Tribolium castaneum (red flour beetle) ENSTNIP00000005092 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000023537 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000004971 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB10042 NV30419 NV14240 LH23266 LH23265 ISCW000775 FBgn0234752 FBgn0226657 FBgn0203494 FBgn0194456 FBgn0171698 JGI_V11_324622 FBgn0078182 FBgn0153078 FBgn0140710 FBgn0121162 FBgn0116892 FBgn0092183 CPIJ004348 CPIJ020232 BGIBMGA006129 ACYPI005307 AGAP009607 AAEL007237 PHUM625790 GLEAN_14736
Stocks & Reagents
Stocks Listed in FlyBase ( 22 )
Bloomington	221 ast1 dppd-ho cl1 296 ex1 ds1 SX astX/SM1 14638 y1 w67c23; P{SUPor-P}astKG07563 222 ast4 dpov1 cl1/CyO, P{sevRas1.V12}FK1 1349 ast1 dppd-ho ed1 dpov1 cl1 2064 ast1 dpps4 dppd-ho ed1 dpov1 cl1/CyO
Kyoto	105796 ast4 dpov1 cl1 106316 ast1 dppd-ho dpo2 105842 ex1 ds1 SX astX/SM1 106283 ast1 dppd-ho ed1 dpov1 cl1 106645 ast1 dpps4 dppd-ho ed1 dpov1 cl1/CyO
VDRC	v7143 w1118; P{GD1376}v7143
	More stocks available...
Genomic Clones ( 2 )
	BACR23E23 BACR35O22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 14 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD02572
Other clones	FI07644
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT07978 AT08046 AT14817 AT15323 AT15411 AT24735 AT30739 AT31968 GH08544
Other clones	EK151434 EK238149 EP01238
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0015905 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33282
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: ast CG4426 (Li, 1999.11)
Source for database merge of
Additional comments	Shs.8 (FBrf0073598) rescues the embryonic lethality of S104E and S1, and the rough eye phenotype of ast, even in the absence of heat shock. On the basis of this rescue, ast and S merged to same gene. Split again on the basis of new molecular data (FBrf0085372).
Other Comments
	ast may function in an Egfr signaling pathway. (Kotarski et al., 1998) Molecular data and phenotypic interactions are consistent with the interpretation that S and ast mutations are lesions within the same gene or within genes that are functionally related. (Higson et al., 1993) Mutations in ast cause pleiotropic phenotypes in embryonic patterns and affect several longitudinal veins. (Diaz-Benjumea and Garcia-Bellido, 1990) Mutants show a small rough eye phenotype with the longitudinal wing veins failing to meet the wing margin. Interact with alleles of S. (Roberts et al., 1985)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078727 RefSeq (Proteins) • NP_523451 DDBJ / EMBL / GenBank • AAC05483 AAF51424 AAK93494 AF047010 AI531506 AW944252 AY052070 Entrez Gene - A searchable database of RefSeq genes. • 33282 UniProtKB/TrEMBL • Q9VPW1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • No name available (IPR000513)
Linkouts
	BioGRID - A database of protein and genetic interactions • 59535 DroID - A comprehensive database of gene and protein interactions. • FBgn0015905 DRSC - Results from RNAi screens. • FBgn0015905 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015905 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4426-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0015905 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33282 InParanoid A subset of ortholog calls from InParanoid. • AAEL007237-PA Aedes aegypti (mosquito) AGAP009607-PA Anopheles gambiae (mosquito) XP_625006.2 Apis mellifera (honey bee) XP_001946426.1 Acyrthosiphon pisum (pea aphid) 218990 Branchiostoma floridae (lancelet) BGIBMGA006129-PA Bombyx mori (silk worm) ENSBTAP00000031777 Bos taurus (bovine) ENSCAFP00000009160 Canis familiaris (dog) ENSCINP00000006981 Ciona intestinalis (sea squirt) cn10150 Cryptococcus neoformans (yeast-like fungus) CPIJ004348 Culex pipens (mosquito) ENSCPOP00000005122 Cavia porcellus (guinea pig) 34308 Capitella spl (polychaete worm) 324622 Daphnia pulex (daphnia) ENSDARP00000084981 Danio rerio (zebra fish) ENSECAP00000011775 Equus caballus (horse) ENSGACP00000008011 Gymnopilus aculeatus (mushroom) ENSGALP00000008299 Gallus gallus (chicken) 132438 Hypsipyla robusta (cedar shoot borer) ENSP00000264992 Homo sapiens (human) ISCW000775-PA Ixodes scapularis (deer tick) 122662 Lottia gigantea (owl limpet) ENSMODP00000014935 Monodelphis domestica (gray opossum) ENSMMUP00000038439 Macaca mulatta (rhesus monkey) ENSMUSP00000035181 Mus musculus (house mouse) 223271 Nematostella vectensis (starlet anemone) XP_001600677.1 Nasonia vitripennis (wasp) ENSOANP00000010799 Ornithorynchus anatinus (platypus) ENSORLP00000004702 Oryzias latipes (japanese killifish) PHUM008656-PA Pediculus humanus (human body louse) ENSPPYP00000015774 Pongo pygmaeus (orangutan) ENSPTRP00000026524 Pan troglodytes (chimpanzee) ENSRNOP00000017743 Rattus norvegicus (norway rat) Smp_080620 Schistosoma mansoni (trematode parasite) XP_001192581.1 Strongylocentrotus purpuratus (purple sea urchin) 57734 Trichoplax adhaerens (metazoa) XP_975212.1 Tribolium castaneum (red flour beetle) ENSTNIP00000005092 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000023537 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000004971 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33282 modMine - Data generated by the modENCODE project. • FBgn0015905 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB10042 NV30419 NV14240 LH23266 LH23265 ISCW000775 FBgn0234752 FBgn0226657 FBgn0203494 FBgn0194456 FBgn0171698 JGI_V11_324622 FBgn0078182 FBgn0153078 FBgn0140710 FBgn0121162 FBgn0116892 FBgn0092183 CPIJ004348 CPIJ020232 BGIBMGA006129 ACYPI005307 AGAP009607 AAEL007237 PHUM625790 GLEAN_14736
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	ast (Dworkin and Gibson., 2006, Duncan and Celniker, 2004, Dworkin and Gibson, 2006, Melcher and Pankratz, 2005, Zeitlinger et al., 2007, Beltran et al., 2007, Pilgram et al., 2011, Dworkin et al., 2011) CG4426 (Keleman et al., 2009.8.5) Sr (Crow and Bender, 2004, Lewis, 1998, ) Star/asteroid (Schnorr and Berg, 1997, Higson et al., 1993)
Name Synonym	asteroid (Crow et al., 2006, Dworkin and Gibson, 2006) Star-recessive
Secondary FlyBase IDs
References ( 49 )
Generate a list of	All references relating to this gene ( 49 )
List References by type	Research paper  ( 22 ) Supplementary material  ( 4 ) Review  ( 3 ) Personal communication to FlyBase  ( 4 ) Abstract  ( 3 ) FlyBase analysis  ( 2 ) Obituary  ( 3 ) Biography  ( 1 ) Curated genome annotation  ( 1 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 2 ) Book  ( 2 )
Recent research papers ( 2 )
	Dworkin et al., 2011, Genetics 187(4): 1171--1184 The effects of weak genetic perturbations on the transcriptome of the wing imaginal disc and its association with wing shape in Drosophila melanogaster. [FBrf0214376] Pilgram et al., 2011, J. Neurosci. 31(2): 492--500 The RhoGAP crossveinless-c Interacts with Dystrophin and Is Required for Synaptic Homeostasis at the Drosophila Neuromuscular Junction. [FBrf0212767] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...