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Gene Dmel\bl

General Information
Symbol	Dmel\bl	Species	D. melanogaster
Name	bancal	Annotation symbol	CG13425
Feature type	protein_coding_gene	FlyBase ID	FBgn0015907
Gene Model Status	Current	Stock availability	15 publicly available
Also Known As	Hrb57A, Q18
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	57A6-57A7	Sequence location	2R:16,475,056..16,494,359 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene bancal is referred to in FlyBase by the symbol Dmel\bl (CG13425, FBgn0015907). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: mRNA binding; transcription factor binding. There is experimental evidence that it is involved in the biological process: regulation of alternative mRNA splicing, via spliceosome. 31 alleles are reported. The phenotypes of these alleles are annotated with: adult segment; organ system subdivision; thoracic segment; external compound sense organ; sense organ; organ system; adult; metathoracic metatarsus; eo support cell; imaginal precursor. It has 6 annotated transcripts and 6 annotated polypeptides. Protein features are: K Homology domain; K Homology domain, type 1. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult thoracico-abdominal ganglion, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1624355_at completely aligns to an exonic region common to each of the 5 FlyBase-annotated transcript isoforms of bl. Gene sequence location is 2R:16475056..16494359.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 57A6-57A7   Limits computationally determined from genome sequence between P{EP}l(2)05510EP2587&P{lacW}rigk07917 and P{lacW}l(2)k02206k02206
Experimentally Determined Cytological Location
Cytogenetic map Notes References 57A-57A   (determined by in situ hybridisation)   (Lukacsovich et al., 2001) 57A3-57A4   (determined by in situ hybridisation)   (Abdelilah-Seyfried et al., 2000) 57A-57A     (Hovemann, 1999.5.7) 57A-57A     (Charroux, 1999.4.13) 57A-57A   (determined by in situ hybridisation)   (Charroux et al., 1999) 57A-57A   (determined by in situ hybridisation)   (Buchenau et al., 1997)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\bl for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters. Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.48
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) bl-RA FBtr0086220  NM_206185   2076   496 bl-RB FBtr0086219  NM_145883   2032   413 bl-RC FBtr0086221  NM_206184   2127   502 bl-RD FBtr0086222  NM_206183   1342   315 bl-RE FBtr0301760  NM_001169745   2101   493 bl-RF FBtr0336730  NM_001274173   2078   496
Additional Transcript Data & Comments
Reported size (kB)	2.1, 1.9 (northern blot) (Charroux et al., 1999) 2.0 (northern blot) (Spradling et al., 1999, Hovemann et al., 2000, Gates and Thummel, 2000)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein bl-PA   FBpp0089365   50.2   496   8.98     NP_995907   AAF57450 bl-PB   FBpp0085537   41.0   413   9.59     NP_665890   AAM68390 bl-PC   FBpp0089363   51.0   502   9.65     NP_995906   AAM68389 bl-PD   FBpp0089364   29.8   315   9.48     NP_995905   AAS64908 bl-PE   FBpp0290974   49.9   493   8.63     NP_001163216   ACZ94488 bl-PF   FBpp0307711   50.2   496   8.98     NP_001261102   AGB93634
Additional Polypeptide Data & Comments
Reported size (kDa)	508 (aa) (Gates and Thummel, 2000, Spradling et al., 1999) 496 (aa); 55 (kD observed); 50 (kD predicted) (Hovemann et al., 2000) 490 (aa); 54 (kD observed); 54 (kD predicted) (Charroux et al., 1999)
Comments	bl protein binds specifically to poly(C). (Hovemann et al., 2000)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • K Homology domain (IPR004087) K Homology domain, type 1 (IPR004088)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202425   AA246875   AA390721   AA441076   AA567339   AA694777   AA695197   AA803682   AA950648   AE013599 AAF57450   AE013599 AAM68389   AE013599 AAM68390   AE013599 AAS64908   AE013599 ACZ94488   AF142631 AAF00596   AF275629 AAF78762   AE013599 AGB93634   AI062165   AI113521   AI387464   AI389318   AI456625   AI516680   AI518052   AI518983   AI543885   AJ238947 CAB64936   AQ024999   AW943790   AY060831   AY069684 AAL39829   BF486816   BG632519   BH900871   BI162561   BI166372   BI167818   BI169231   BI169927   BI173683   BI173707   BI213163   BI213179   BI215994   BI229672   BI232675   BI235984   BI236201   BI238191   BI239496   BI351738   BI365117   BI369095   BI370149   BI370422   BI482946   BI605635   BI633175   BP550709   BT001672 AAN71427   BT032853   BT100041   BT100100   CK661815   CL610257   CO178013   CO268833   CO268867   CO275924   CO275969   CO276385   CO276404   CO277854   CO278198   CO283377   CO285384   CO290188   CO293284   CO293831   CO302504   CO304420   CO310548   CO320168   CO328365   CO331880   CO332294   CO336716   CO339538   CO342840   CZ470648   CZ470649   CZ478025   CZ479660   CZ480010   CZ480442   EC055218   EC060023   EC062000   EC062852   EC066573   EC071043   EC197168   EC212559   EC217984   EC219185   EC221426   EC225146   EC231987   EC237283   EC243390   EC245734   EC247247   EC251048   EC251124   EC251741   EC259940   EC262369   EL871238   ES692323   EV587440   EV591303   GH965199   GH970291   GH972730
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	A1ZBW0 A1ZBW3 A1ZBW1 A1ZBW4 E1JGN7 Q8SZZ6 Q7KHL0 Q9V948 Q7KA80 Q8IGP8
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References regulatory region FBsf0000435683 2R:16,485,383..16,485,745 evidence=Reporter construct (in vivo) (Ochoa-Espinosa et al., 2005, Halfon, 2012.6.19)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Charroux et al., 1999) embryonic stage 1 -- 13     (Charroux et al., 1999) Comment:reference states <=10 hr AEL larval stage & pupal stage     (Spradling et al., 1999, Gates and Thummel, 2000) third instar larval stage     (Charroux et al., 1999) adult stage | female     (Charroux et al., 1999)
Additional Descriptive Data
	the 2.1kb bl transcript is expressed at all stages tested. (Charroux et al., 1999) bl transcripts are detected in late third instar larvae. bl transcription is induced by ecdysone. (Spradling et al., 1999)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism | ubiquitous   (Charroux et al., 1999) embryonic stage 4 -- 12   somatic cell   • nucleus (Hovemann et al., 2000) embryonic cycle 10 -- embryonic cycle 12   embryonic cortex   • cytoplasm (Charroux et al., 1999) embryonic cycle 13   embryonic cortex   • cytoplasm & nucleus (Charroux et al., 1999) pole cell   • cytoplasm (Charroux et al., 1999) Comment:NOT nucleus embryonic stage 5 -- 17   somatic cell   • nucleus (Charroux et al., 1999) Comment:interphase nuclei embryonic cycle 14   somatic cell   • nucleus (Charroux et al., 1999) embryonic stage 9   amnioserosa   • nucleus (Charroux et al., 1999) third instar larval stage   imaginal disc   (Charroux et al., 1999) imaginal disc   • nucleus (Charroux et al., 1999) Comment:interphase nuclei mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010) western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism   (Charroux et al., 1999) larval stage   imaginal disc   (Charroux et al., 1999) adult stage | female   ovary   (Charroux et al., 1999)
Additional Descriptive Data
	bl protein is located in puffs and prominent interbands (sites engaged in transcription) on polytene chromosomes. (Hovemann et al., 2000) bl protein is present in early embryos where it undergoes redistribution from cytoplasm to nucleus that coincides with the initation of zygotic transcription in early embryos. During nuclear cycles 10-12, it is present in the cytoplasm and by cycle 14, it is exclusively nuclear. From cycle 14 throughout the rest of embryogenesis and in imaginal discs, the protein is present in all interphase nuclei. (Buchenau et al., 1997, Charroux et al., 1999)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
chromatin inferred from direct assay (Prasanth et al., 2000) nucleus inferred from direct assay (Prasanth et al., 2000) omega speckle inferred from direct assay (Prasanth et al., 2000)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult thoracico-abdominal ganglion, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    764.975 Larval Midgut    150 Larval Hindgut    196.2 Larval Malpighian Tubules    298.6 Larval Fat Body    125.6 Larval Salivary Gland    161.3 Larval Trachea    300.5 Larval Carcass    203.5 Adult Head    257.8 Adult Eye    272.875 Adult Brain    619.6 Adult Thoracic-Abdominal Ganglion    456.8 Adult Crop    172.8 Adult Midgut    149.4 Adult Hindgut    171.4 Adult Malpighian Tubules    274.3 Adult Fat Body    148.8 Adult Salivary Gland    141.4 Adult Heart    133.725 Adult VirginFemale Spermatheca    121 Adult InseminatedFemale Spermatheca    147.5 Adult Ovary    216.9 Adult Testis    157.7 Adult Male Accessory Gland    193.1 Adult Carcass    157.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (764.975) Larval Midgut    150 Larval Hindgut    196.2 Larval Malpighian Tubules    298.6 Larval Fat Body    125.6 Larval Salivary Gland    161.3 Larval Trachea    300.5 Larval Carcass    203.5 Adult Head    257.8 Adult Eye    272.875 Adult Brain  (619.6) Adult Thoracic-Abdominal Ganglion    456.8 Adult Crop    172.8 Adult Midgut    149.4 Adult Hindgut    171.4 Adult Malpighian Tubules    274.3 Adult Fat Body    148.8 Adult Salivary Gland    141.4 Adult Heart    133.725 Adult VirginFemale Spermatheca    121 Adult InseminatedFemale Spermatheca    147.5 Adult Ovary    216.9 Adult Testis    157.7 Adult Male Accessory Gland    193.1 Adult Carcass    157.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    764.975 Larval Midgut    150 Larval Hindgut    196.2 Larval Malpighian Tubules    298.6 Larval Fat Body    125.6 Larval Salivary Gland    161.3 Larval Trachea    300.5 Larval Carcass    203.5 Adult Head    257.8 Adult Eye    272.875 Adult Brain    619.6 Adult Thoracic-Abdominal Ganglion    456.8 Adult Crop    172.8 Adult Midgut    149.4 Adult Hindgut    171.4 Adult Malpighian Tubules    274.3 Adult Fat Body    148.8 Adult Salivary Gland    141.4 Adult Heart    133.725 Adult VirginFemale Spermatheca    121 Adult InseminatedFemale Spermatheca    147.5 Adult Ovary    216.9 Adult Testis    157.7 Adult Male Accessory Gland    193.1 Adult Carcass    157.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    764.975 Larval Midgut    150 Larval Hindgut    196.2 Larval Malpighian Tubules    298.6 Larval Fat Body    125.6 Larval Salivary Gland    161.3 Larval Trachea    300.5 Larval Carcass    203.5 Adult Head    257.8 Adult Eye    272.875 Adult Brain    619.6 Adult Thoracic-Abdominal Ganglion    456.8 Adult Crop    172.8 Adult Midgut    149.4 Adult Hindgut    171.4 Adult Malpighian Tubules    274.3 Adult Fat Body    148.8 Adult Salivary Gland    141.4 Adult Heart    133.725 Adult VirginFemale Spermatheca    121 Adult InseminatedFemale Spermatheca    147.5 Adult Ovary    216.9 Adult Testis    157.7 Adult Male Accessory Gland    193.1 Adult Carcass    157.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    764.975 Larval Midgut    150 Larval Hindgut    196.2 Larval Malpighian Tubules    298.6 Larval Fat Body    125.6 Larval Salivary Gland    161.3 Larval Trachea    300.5 Larval Carcass    203.5 Adult Head    257.8 Adult Eye    272.875 Adult Brain    619.6 Adult Thoracic-Abdominal Ganglion    456.8 Adult Crop    172.8 Adult Midgut    149.4 Adult Hindgut    171.4 Adult Malpighian Tubules    274.3 Adult Fat Body    148.8 Adult Salivary Gland    141.4 Adult Heart    133.725 Adult VirginFemale Spermatheca    121 Adult InseminatedFemale Spermatheca    147.5 Adult Ovary    216.9 Adult Testis    157.7 Adult Male Accessory Gland    193.1 Adult Carcass    157.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  764.975 Larval Midgut    150 Larval Hindgut    196.2 Larval Malpighian Tubules    298.6 Larval Fat Body    125.6 Larval Salivary Gland    161.3 Larval Trachea    300.5 Larval Carcass    203.5 Adult Head    257.8 Adult Eye    272.875 Adult Brain  619.6 Adult Thoracic-Abdominal Ganglion    456.8 Adult Crop    172.8 Adult Midgut    149.4 Adult Hindgut    171.4 Adult Malpighian Tubules    274.3 Adult Fat Body    148.8 Adult Salivary Gland    141.4 Adult Heart    133.725 Adult VirginFemale Spermatheca    121 Adult InseminatedFemale Spermatheca    147.5 Adult Ovary    216.9 Adult Testis    157.7 Adult Male Accessory Gland    193.1 Adult Carcass    157.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    764.975 Larval Midgut    150 Larval Hindgut    196.2 Larval Malpighian Tubules    298.6 Larval Fat Body    125.6 Larval Salivary Gland    161.3 Larval Trachea    300.5 Larval Carcass    203.5 Adult Head    257.8 Adult Eye    272.875 Adult Brain    619.6 Adult Thoracic-Abdominal Ganglion    456.8 Adult Crop    172.8 Adult Midgut    149.4 Adult Hindgut    171.4 Adult Malpighian Tubules    274.3 Adult Fat Body    148.8 Adult Salivary Gland    141.4 Adult Heart    133.725 Adult VirginFemale Spermatheca    121 Adult InseminatedFemale Spermatheca    147.5 Adult Ovary    216.9 Adult Testis    157.7 Adult Male Accessory Gland    193.1 Adult Carcass    157.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    764.975 Larval Midgut    150 Larval Hindgut    196.2 Larval Malpighian Tubules    298.6 Larval Fat Body    125.6 Larval Salivary Gland    161.3 Larval Trachea    300.5 Larval Carcass    203.5 Adult Head    257.8 Adult Eye    272.875 Adult Brain    619.6 Adult Thoracic-Abdominal Ganglion    456.8 Adult Crop    172.8 Adult Midgut    149.4 Adult Hindgut    171.4 Adult Malpighian Tubules    274.3 Adult Fat Body    148.8 Adult Salivary Gland    141.4 Adult Heart    133.725 Adult VirginFemale Spermatheca    121 Adult InseminatedFemale Spermatheca    147.5 Adult Ovary    216.9 Adult Testis    157.7 Adult Male Accessory Gland    193.1 Adult Carcass    157.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    257.8   NA  Eye    272.875   NA  Brain    619.6   764.975  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    456.8   NA  Crop    172.8   150  Midgut    149.4   196.2  Hindgut    171.4   298.6  Malpighian Tubules    274.3   125.6  Fat Body    148.8   161.3  Salivary Gland    141.4   NA  Heart    133.725   300.5  Trachea    NA   NA  VirginFemale Spermatheca    121   NA  InseminatedFemale Spermatheca    147.5   NA  Ovary    216.9   NA  Testis    157.7   NA  Male Accessory Gland    193.1   203.5  Carcass    157.5 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    117 central nervous system, larvae L3    173 central nervous system, pupae P8    92 head, virgin 1-day female    40 head, virgin 4-day female    46 head, virgin 20-day female    34 head, mated 1-day female    38 head, mated 4-day female    41 head, mated 20-day female    31 head, mated 1-day male    54 head, mated 4-day male    64 head, mated 20-day male    71 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    22 digestive system, larvae L3 wandering    47 digestive system, 1-day adult    20 digestive system, 4-day adult    26 digestive system, 20-day adult    22 fat body, larvae L3 wandering    17 fat body, white prepupae    47 fat body, pupae P8    84 carcass, larvae L3 wandering    107 carcass, 1-day adult    22 carcass, 4-day adult    27 carcass, 20-day adult    22 ovary, virgin 4-day female    61 ovary, mated 4-day female    59 testis, mated 4-day male    49 accessory gland, mated 4-day male    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (117) central nervous system, larvae L3  (173) central nervous system, pupae P8  (92) head, virgin 1-day female  (40) head, virgin 4-day female  (46) head, virgin 20-day female  (34) head, mated 1-day female  (38) head, mated 4-day female  (41) head, mated 20-day female  (31) head, mated 1-day male  (54) head, mated 4-day male  (64) head, mated 20-day male  (71) salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    22 digestive system, larvae L3 wandering  (47) digestive system, 1-day adult    20 digestive system, 4-day adult  26 digestive system, 20-day adult    22 fat body, larvae L3 wandering    17 fat body, white prepupae  (47) fat body, pupae P8  (84) carcass, larvae L3 wandering  (107) carcass, 1-day adult    22 carcass, 4-day adult  (27) carcass, 20-day adult    22 ovary, virgin 4-day female  (61) ovary, mated 4-day female  (59) testis, mated 4-day male  (49) accessory gland, mated 4-day male    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (117) central nervous system, larvae L3  (173) central nervous system, pupae P8    92 head, virgin 1-day female    40 head, virgin 4-day female    46 head, virgin 20-day female    34 head, mated 1-day female    38 head, mated 4-day female    41 head, mated 20-day female    31 head, mated 1-day male    54 head, mated 4-day male    64 head, mated 20-day male    71 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    22 digestive system, larvae L3 wandering    47 digestive system, 1-day adult    20 digestive system, 4-day adult    26 digestive system, 20-day adult    22 fat body, larvae L3 wandering    17 fat body, white prepupae    47 fat body, pupae P8    84 carcass, larvae L3 wandering  107 carcass, 1-day adult    22 carcass, 4-day adult    27 carcass, 20-day adult    22 ovary, virgin 4-day female    61 ovary, mated 4-day female    59 testis, mated 4-day male    49 accessory gland, mated 4-day male    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    117 central nervous system, larvae L3    173 central nervous system, pupae P8    92 head, virgin 1-day female    40 head, virgin 4-day female    46 head, virgin 20-day female    34 head, mated 1-day female    38 head, mated 4-day female    41 head, mated 20-day female    31 head, mated 1-day male    54 head, mated 4-day male    64 head, mated 20-day male    71 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    22 digestive system, larvae L3 wandering    47 digestive system, 1-day adult    20 digestive system, 4-day adult    26 digestive system, 20-day adult    22 fat body, larvae L3 wandering    17 fat body, white prepupae    47 fat body, pupae P8    84 carcass, larvae L3 wandering    107 carcass, 1-day adult    22 carcass, 4-day adult    27 carcass, 20-day adult    22 ovary, virgin 4-day female    61 ovary, mated 4-day female    59 testis, mated 4-day male    49 accessory gland, mated 4-day male    19 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    117 central nervous system, larvae L3    173 central nervous system, pupae P8    92 head, virgin 1-day female    40 head, virgin 4-day female    46 head, virgin 20-day female    34 head, mated 1-day female    38 head, mated 4-day female    41 head, mated 20-day female    31 head, mated 1-day male    54 head, mated 4-day male    64 head, mated 20-day male    71 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    22 digestive system, larvae L3 wandering    47 digestive system, 1-day adult    20 digestive system, 4-day adult    26 digestive system, 20-day adult    22 fat body, larvae L3 wandering    17 fat body, white prepupae    47 fat body, pupae P8    84 carcass, larvae L3 wandering    107 carcass, 1-day adult    22 carcass, 4-day adult    27 carcass, 20-day adult    22 ovary, virgin 4-day female    61 ovary, mated 4-day female    59 testis, mated 4-day male    49 accessory gland, mated 4-day male    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (117) central nervous system, larvae L3  (173) central nervous system, pupae P8  (92) head, virgin 1-day female  (40) head, virgin 4-day female  (46) head, virgin 20-day female  (34) head, mated 1-day female  (38) head, mated 4-day female  (41) head, mated 20-day female  31 head, mated 1-day male  (54) head, mated 4-day male  (64) head, mated 20-day male  (71) salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    22 digestive system, larvae L3 wandering  (47) digestive system, 1-day adult    20 digestive system, 4-day adult  26 digestive system, 20-day adult    22 fat body, larvae L3 wandering    17 fat body, white prepupae  (47) fat body, pupae P8  (84) carcass, larvae L3 wandering  (107) carcass, 1-day adult    22 carcass, 4-day adult  27 carcass, 20-day adult    22 ovary, virgin 4-day female  (61) ovary, mated 4-day female  (59) testis, mated 4-day male  (49) accessory gland, mated 4-day male    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  117 central nervous system, larvae L3  (173) central nervous system, pupae P8    92 head, virgin 1-day female    40 head, virgin 4-day female    46 head, virgin 20-day female    34 head, mated 1-day female    38 head, mated 4-day female    41 head, mated 20-day female    31 head, mated 1-day male    54 head, mated 4-day male    64 head, mated 20-day male    71 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    22 digestive system, larvae L3 wandering    47 digestive system, 1-day adult    20 digestive system, 4-day adult    26 digestive system, 20-day adult    22 fat body, larvae L3 wandering    17 fat body, white prepupae    47 fat body, pupae P8    84 carcass, larvae L3 wandering  107 carcass, 1-day adult    22 carcass, 4-day adult    27 carcass, 20-day adult    22 ovary, virgin 4-day female    61 ovary, mated 4-day female    59 testis, mated 4-day male    49 accessory gland, mated 4-day male    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    117 central nervous system, larvae L3    173 central nervous system, pupae P8    92 head, virgin 1-day female    40 head, virgin 4-day female    46 head, virgin 20-day female    34 head, mated 1-day female    38 head, mated 4-day female    41 head, mated 20-day female    31 head, mated 1-day male    54 head, mated 4-day male    64 head, mated 20-day male    71 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    22 digestive system, larvae L3 wandering    47 digestive system, 1-day adult    20 digestive system, 4-day adult    26 digestive system, 20-day adult    22 fat body, larvae L3 wandering    17 fat body, white prepupae    47 fat body, pupae P8    84 carcass, larvae L3 wandering    107 carcass, 1-day adult    22 carcass, 4-day adult    27 carcass, 20-day adult    22 ovary, virgin 4-day female    61 ovary, mated 4-day female    59 testis, mated 4-day male    49 accessory gland, mated 4-day male    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    57 embryo 02-04hr    152 embryo 04-06hr    189 embryo 06-08hr    233 embryo 08-10hr    188 embryo 10-12hr    144 embryo 12-14hr    93 embryo 14-16hr    81 embryo 16-18hr    61 embryo 18-20hr    53 embryo 20-22hr    43 embryo 22-24hr    41 larva L1    38 larva L2    36 larva L3 12hr old    29 larva L3 puffstage 1-2    32 larva L3 puffstage 3-6    52 larva L3 puffstage 7-9    63 white prepupae new    68 white prepupae 12hr    67 white prepupae 24hr    83 pupae 2d postWPP    59 pupae 3d postWPP    39 pupae 4d postWPP    35 adult male 01day    32 adult male 05day    38 adult male 30day    39 adult female 01day    43 adult female 05day    49 adult female 30day    47 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (57) embryo 02-04hr  (152) embryo 04-06hr  (189) embryo 06-08hr  (233) embryo 08-10hr  (188) embryo 10-12hr  (144) embryo 12-14hr  (93) embryo 14-16hr  (81) embryo 16-18hr  (61) embryo 18-20hr  (53) embryo 20-22hr  (43) embryo 22-24hr  (41) larva L1  (38) larva L2  (36) larva L3 12hr old  (29) larva L3 puffstage 1-2  (32) larva L3 puffstage 3-6  (52) larva L3 puffstage 7-9  (63) white prepupae new  (68) white prepupae 12hr  (67) white prepupae 24hr  (83) pupae 2d postWPP  (59) pupae 3d postWPP  (39) pupae 4d postWPP  (35) adult male 01day  (32) adult male 05day  (38) adult male 30day  (39) adult female 01day  (43) adult female 05day  (49) adult female 30day  (47) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    57 embryo 02-04hr  (152) embryo 04-06hr  (189) embryo 06-08hr  (233) embryo 08-10hr  (188) embryo 10-12hr  (144) embryo 12-14hr    93 embryo 14-16hr    81 embryo 16-18hr    61 embryo 18-20hr    53 embryo 20-22hr    43 embryo 22-24hr    41 larva L1    38 larva L2    36 larva L3 12hr old    29 larva L3 puffstage 1-2    32 larva L3 puffstage 3-6    52 larva L3 puffstage 7-9    63 white prepupae new    68 white prepupae 12hr    67 white prepupae 24hr    83 pupae 2d postWPP    59 pupae 3d postWPP    39 pupae 4d postWPP    35 adult male 01day    32 adult male 05day    38 adult male 30day    39 adult female 01day    43 adult female 05day    49 adult female 30day    47 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    57 embryo 02-04hr    152 embryo 04-06hr    189 embryo 06-08hr    233 embryo 08-10hr    188 embryo 10-12hr    144 embryo 12-14hr    93 embryo 14-16hr    81 embryo 16-18hr    61 embryo 18-20hr    53 embryo 20-22hr    43 embryo 22-24hr    41 larva L1    38 larva L2    36 larva L3 12hr old    29 larva L3 puffstage 1-2    32 larva L3 puffstage 3-6    52 larva L3 puffstage 7-9    63 white prepupae new    68 white prepupae 12hr    67 white prepupae 24hr    83 pupae 2d postWPP    59 pupae 3d postWPP    39 pupae 4d postWPP    35 adult male 01day    32 adult male 05day    38 adult male 30day    39 adult female 01day    43 adult female 05day    49 adult female 30day    47 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    57 embryo 02-04hr    152 embryo 04-06hr    189 embryo 06-08hr    233 embryo 08-10hr    188 embryo 10-12hr    144 embryo 12-14hr    93 embryo 14-16hr    81 embryo 16-18hr    61 embryo 18-20hr    53 embryo 20-22hr    43 embryo 22-24hr    41 larva L1    38 larva L2    36 larva L3 12hr old    29 larva L3 puffstage 1-2    32 larva L3 puffstage 3-6    52 larva L3 puffstage 7-9    63 white prepupae new    68 white prepupae 12hr    67 white prepupae 24hr    83 pupae 2d postWPP    59 pupae 3d postWPP    39 pupae 4d postWPP    35 adult male 01day    32 adult male 05day    38 adult male 30day    39 adult female 01day    43 adult female 05day    49 adult female 30day    47 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (57) embryo 02-04hr  (152) embryo 04-06hr  (189) embryo 06-08hr  (233) embryo 08-10hr  (188) embryo 10-12hr  (144) embryo 12-14hr  (93) embryo 14-16hr  (81) embryo 16-18hr  (61) embryo 18-20hr  (53) embryo 20-22hr  (43) embryo 22-24hr  (41) larva L1  (38) larva L2  (36) larva L3 12hr old  29 larva L3 puffstage 1-2  32 larva L3 puffstage 3-6  (52) larva L3 puffstage 7-9  (63) white prepupae new  (68) white prepupae 12hr  (67) white prepupae 24hr  (83) pupae 2d postWPP  (59) pupae 3d postWPP  (39) pupae 4d postWPP  (35) adult male 01day  32 adult male 05day  (38) adult male 30day  (39) adult female 01day  (43) adult female 05day  (49) adult female 30day  (47) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    57 embryo 02-04hr  (152) embryo 04-06hr  (189) embryo 06-08hr  (233) embryo 08-10hr  (188) embryo 10-12hr  (144) embryo 12-14hr    93 embryo 14-16hr    81 embryo 16-18hr    61 embryo 18-20hr    53 embryo 20-22hr    43 embryo 22-24hr    41 larva L1    38 larva L2    36 larva L3 12hr old    29 larva L3 puffstage 1-2    32 larva L3 puffstage 3-6    52 larva L3 puffstage 7-9    63 white prepupae new    68 white prepupae 12hr    67 white prepupae 24hr    83 pupae 2d postWPP    59 pupae 3d postWPP    39 pupae 4d postWPP    35 adult male 01day    32 adult male 05day    38 adult male 30day    39 adult female 01day    43 adult female 05day    49 adult female 30day    47 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    57 embryo 02-04hr    152 embryo 04-06hr    189 embryo 06-08hr    233 embryo 08-10hr    188 embryo 10-12hr    144 embryo 12-14hr    93 embryo 14-16hr    81 embryo 16-18hr    61 embryo 18-20hr    53 embryo 20-22hr    43 embryo 22-24hr    41 larva L1    38 larva L2    36 larva L3 12hr old    29 larva L3 puffstage 1-2    32 larva L3 puffstage 3-6    52 larva L3 puffstage 7-9    63 white prepupae new    68 white prepupae 12hr    67 white prepupae 24hr    83 pupae 2d postWPP    59 pupae 3d postWPP    39 pupae 4d postWPP    35 adult male 01day    32 adult male 05day    38 adult male 30day    39 adult female 01day    43 adult female 05day    49 adult female 30day    47 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    120 Schneider line 2 Sg4    81 embryonic 1182-4H    94 embryonic GM2    65 embryonic Kc167    68 embryonic S1    90 embryonic S3    104 leg disc CME L1    69 wing disc CME-W2    58 wing disc ML-DmD8    93 wing disc ML-DmD9    99 wing disc ML-DmD16-c3    96 wing disc ML-DmD21    127 wing disc ML-DmD32    92 haltere disc ML-DmD17-c3    113 eye-antennal disc ML-DmD11    96 antennal disc ML-DmD20-c5    96 mixed discs ML-DmD4-c1    123 CNS ML-DmBG1-c1    123 CNS ML-DmBG2-c2    123 tumorous blood cells mbn2    74 ovary fGS/OSS    85 ovary OSC    92 ovary OSS    54 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (120) Schneider line 2 Sg4  (81) embryonic 1182-4H  (94) embryonic GM2  (65) embryonic Kc167  (68) embryonic S1  (90) embryonic S3  (104) leg disc CME L1  (69) wing disc CME-W2  (58) wing disc ML-DmD8  (93) wing disc ML-DmD9  (99) wing disc ML-DmD16-c3  (96) wing disc ML-DmD21  (127) wing disc ML-DmD32  (92) haltere disc ML-DmD17-c3  (113) eye-antennal disc ML-DmD11  (96) antennal disc ML-DmD20-c5  (96) mixed discs ML-DmD4-c1  (123) CNS ML-DmBG1-c1  (123) CNS ML-DmBG2-c2  (123) tumorous blood cells mbn2  (74) ovary fGS/OSS  (85) ovary OSC  (92) ovary OSS  (54) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (120) Schneider line 2 Sg4    81 embryonic 1182-4H    94 embryonic GM2    65 embryonic Kc167    68 embryonic S1    90 embryonic S3  104 leg disc CME L1    69 wing disc CME-W2    58 wing disc ML-DmD8    93 wing disc ML-DmD9    99 wing disc ML-DmD16-c3    96 wing disc ML-DmD21  (127) wing disc ML-DmD32    92 haltere disc ML-DmD17-c3  (113) eye-antennal disc ML-DmD11    96 antennal disc ML-DmD20-c5    96 mixed discs ML-DmD4-c1  (123) CNS ML-DmBG1-c1  (123) CNS ML-DmBG2-c2  (123) tumorous blood cells mbn2    74 ovary fGS/OSS    85 ovary OSC    92 ovary OSS    54 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    120 Schneider line 2 Sg4    81 embryonic 1182-4H    94 embryonic GM2    65 embryonic Kc167    68 embryonic S1    90 embryonic S3    104 leg disc CME L1    69 wing disc CME-W2    58 wing disc ML-DmD8    93 wing disc ML-DmD9    99 wing disc ML-DmD16-c3    96 wing disc ML-DmD21    127 wing disc ML-DmD32    92 haltere disc ML-DmD17-c3    113 eye-antennal disc ML-DmD11    96 antennal disc ML-DmD20-c5    96 mixed discs ML-DmD4-c1    123 CNS ML-DmBG1-c1    123 CNS ML-DmBG2-c2    123 tumorous blood cells mbn2    74 ovary fGS/OSS    85 ovary OSC    92 ovary OSS    54 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    120 Schneider line 2 Sg4    81 embryonic 1182-4H    94 embryonic GM2    65 embryonic Kc167    68 embryonic S1    90 embryonic S3    104 leg disc CME L1    69 wing disc CME-W2    58 wing disc ML-DmD8    93 wing disc ML-DmD9    99 wing disc ML-DmD16-c3    96 wing disc ML-DmD21    127 wing disc ML-DmD32    92 haltere disc ML-DmD17-c3    113 eye-antennal disc ML-DmD11    96 antennal disc ML-DmD20-c5    96 mixed discs ML-DmD4-c1    123 CNS ML-DmBG1-c1    123 CNS ML-DmBG2-c2    123 tumorous blood cells mbn2    74 ovary fGS/OSS    85 ovary OSC    92 ovary OSS    54 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (120) Schneider line 2 Sg4  (81) embryonic 1182-4H  (94) embryonic GM2  (65) embryonic Kc167  (68) embryonic S1  (90) embryonic S3  (104) leg disc CME L1  (69) wing disc CME-W2  (58) wing disc ML-DmD8  (93) wing disc ML-DmD9  (99) wing disc ML-DmD16-c3  (96) wing disc ML-DmD21  (127) wing disc ML-DmD32  (92) haltere disc ML-DmD17-c3  (113) eye-antennal disc ML-DmD11  (96) antennal disc ML-DmD20-c5  (96) mixed discs ML-DmD4-c1  (123) CNS ML-DmBG1-c1  (123) CNS ML-DmBG2-c2  (123) tumorous blood cells mbn2  (74) ovary fGS/OSS  (85) ovary OSC  (92) ovary OSS  (54) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  120 Schneider line 2 Sg4    81 embryonic 1182-4H    94 embryonic GM2    65 embryonic Kc167    68 embryonic S1    90 embryonic S3  104 leg disc CME L1    69 wing disc CME-W2    58 wing disc ML-DmD8    93 wing disc ML-DmD9    99 wing disc ML-DmD16-c3    96 wing disc ML-DmD21  127 wing disc ML-DmD32    92 haltere disc ML-DmD17-c3  113 eye-antennal disc ML-DmD11    96 antennal disc ML-DmD20-c5    96 mixed discs ML-DmD4-c1  123 CNS ML-DmBG1-c1  123 CNS ML-DmBG2-c2  123 tumorous blood cells mbn2    74 ovary fGS/OSS    85 ovary OSC    92 ovary OSS    54 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    120 Schneider line 2 Sg4    81 embryonic 1182-4H    94 embryonic GM2    65 embryonic Kc167    68 embryonic S1    90 embryonic S3    104 leg disc CME L1    69 wing disc CME-W2    58 wing disc ML-DmD8    93 wing disc ML-DmD9    99 wing disc ML-DmD16-c3    96 wing disc ML-DmD21    127 wing disc ML-DmD32    92 haltere disc ML-DmD17-c3    113 eye-antennal disc ML-DmD11    96 antennal disc ML-DmD20-c5    96 mixed discs ML-DmD4-c1    123 CNS ML-DmBG1-c1    123 CNS ML-DmBG2-c2    123 tumorous blood cells mbn2    74 ovary fGS/OSS    85 ovary OSC    92 ovary OSS    54 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    45 cold shock, 4-day adult    39 heat shock, 4-day adult    35 Cadmium 50 mM 6 hrs, larvae L3    25 Cadmium 50 mM 12 hrs, larvae L3    36 Cadmium 50 mM 48 hrs, 4-day adult    38 Cadmium 100 mM 48 hrs, 4-day adult    48 Copper 0.5 mM 12 hrs, larvae L3    34 Copper 15 mM 48 hrs, 4-day adult    36 Zinc 5 mM 12 hrs, larvae L3    27 Zinc 4.5 mM 48 hrs, 4-day adult    46 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    25 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    47 Caffeine 25 mg/ml 48 hrs, 4-day adult    35 Paraquat 5 mM 48 hrs, 4-day adult    47 Paraquat 10 mM 48 hrs, 4-day adult    46 Rotenone 2 μg 12 hrs, larvae L3    27 Rotenone 8 μg 12 hrs, larvae L3    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (45) cold shock, 4-day adult  (39) heat shock, 4-day adult  (35) Cadmium 50 mM 6 hrs, larvae L3    25 Cadmium 50 mM 12 hrs, larvae L3  (36) Cadmium 50 mM 48 hrs, 4-day adult  (38) Cadmium 100 mM 48 hrs, 4-day adult  (48) Copper 0.5 mM 12 hrs, larvae L3  (34) Copper 15 mM 48 hrs, 4-day adult  (36) Zinc 5 mM 12 hrs, larvae L3  (27) Zinc 4.5 mM 48 hrs, 4-day adult  (46) Ethanol 2.5% 3 hrs, larvae L3  (44) Ethanol 5% 3 hrs, larvae L3    25 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (47) Caffeine 25 mg/ml 48 hrs, 4-day adult  (35) Paraquat 5 mM 48 hrs, 4-day adult  (47) Paraquat 10 mM 48 hrs, 4-day adult  (46) Rotenone 2 μg 12 hrs, larvae L3  (27) Rotenone 8 μg 12 hrs, larvae L3    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    45 cold shock, 4-day adult    39 heat shock, 4-day adult    35 Cadmium 50 mM 6 hrs, larvae L3    25 Cadmium 50 mM 12 hrs, larvae L3    36 Cadmium 50 mM 48 hrs, 4-day adult    38 Cadmium 100 mM 48 hrs, 4-day adult    48 Copper 0.5 mM 12 hrs, larvae L3    34 Copper 15 mM 48 hrs, 4-day adult    36 Zinc 5 mM 12 hrs, larvae L3    27 Zinc 4.5 mM 48 hrs, 4-day adult    46 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    25 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    47 Caffeine 25 mg/ml 48 hrs, 4-day adult    35 Paraquat 5 mM 48 hrs, 4-day adult    47 Paraquat 10 mM 48 hrs, 4-day adult    46 Rotenone 2 μg 12 hrs, larvae L3    27 Rotenone 8 μg 12 hrs, larvae L3    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    45 cold shock, 4-day adult    39 heat shock, 4-day adult    35 Cadmium 50 mM 6 hrs, larvae L3    25 Cadmium 50 mM 12 hrs, larvae L3    36 Cadmium 50 mM 48 hrs, 4-day adult    38 Cadmium 100 mM 48 hrs, 4-day adult    48 Copper 0.5 mM 12 hrs, larvae L3    34 Copper 15 mM 48 hrs, 4-day adult    36 Zinc 5 mM 12 hrs, larvae L3    27 Zinc 4.5 mM 48 hrs, 4-day adult    46 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    25 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    47 Caffeine 25 mg/ml 48 hrs, 4-day adult    35 Paraquat 5 mM 48 hrs, 4-day adult    47 Paraquat 10 mM 48 hrs, 4-day adult    46 Rotenone 2 μg 12 hrs, larvae L3    27 Rotenone 8 μg 12 hrs, larvae L3    20 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    45 cold shock, 4-day adult    39 heat shock, 4-day adult    35 Cadmium 50 mM 6 hrs, larvae L3    25 Cadmium 50 mM 12 hrs, larvae L3    36 Cadmium 50 mM 48 hrs, 4-day adult    38 Cadmium 100 mM 48 hrs, 4-day adult    48 Copper 0.5 mM 12 hrs, larvae L3    34 Copper 15 mM 48 hrs, 4-day adult    36 Zinc 5 mM 12 hrs, larvae L3    27 Zinc 4.5 mM 48 hrs, 4-day adult    46 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    25 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    47 Caffeine 25 mg/ml 48 hrs, 4-day adult    35 Paraquat 5 mM 48 hrs, 4-day adult    47 Paraquat 10 mM 48 hrs, 4-day adult    46 Rotenone 2 μg 12 hrs, larvae L3    27 Rotenone 8 μg 12 hrs, larvae L3    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (45) cold shock, 4-day adult  (39) heat shock, 4-day adult  (35) Cadmium 50 mM 6 hrs, larvae L3    25 Cadmium 50 mM 12 hrs, larvae L3  (36) Cadmium 50 mM 48 hrs, 4-day adult  (38) Cadmium 100 mM 48 hrs, 4-day adult  (48) Copper 0.5 mM 12 hrs, larvae L3  (34) Copper 15 mM 48 hrs, 4-day adult  (36) Zinc 5 mM 12 hrs, larvae L3  27 Zinc 4.5 mM 48 hrs, 4-day adult  (46) Ethanol 2.5% 3 hrs, larvae L3  (44) Ethanol 5% 3 hrs, larvae L3    25 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (47) Caffeine 25 mg/ml 48 hrs, 4-day adult  (35) Paraquat 5 mM 48 hrs, 4-day adult  (47) Paraquat 10 mM 48 hrs, 4-day adult  (46) Rotenone 2 μg 12 hrs, larvae L3  27 Rotenone 8 μg 12 hrs, larvae L3    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    45 cold shock, 4-day adult    39 heat shock, 4-day adult    35 Cadmium 50 mM 6 hrs, larvae L3    25 Cadmium 50 mM 12 hrs, larvae L3    36 Cadmium 50 mM 48 hrs, 4-day adult    38 Cadmium 100 mM 48 hrs, 4-day adult    48 Copper 0.5 mM 12 hrs, larvae L3    34 Copper 15 mM 48 hrs, 4-day adult    36 Zinc 5 mM 12 hrs, larvae L3    27 Zinc 4.5 mM 48 hrs, 4-day adult    46 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    25 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    47 Caffeine 25 mg/ml 48 hrs, 4-day adult    35 Paraquat 5 mM 48 hrs, 4-day adult    47 Paraquat 10 mM 48 hrs, 4-day adult    46 Rotenone 2 μg 12 hrs, larvae L3    27 Rotenone 8 μg 12 hrs, larvae L3    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    45 cold shock, 4-day adult    39 heat shock, 4-day adult    35 Cadmium 50 mM 6 hrs, larvae L3    25 Cadmium 50 mM 12 hrs, larvae L3    36 Cadmium 50 mM 48 hrs, 4-day adult    38 Cadmium 100 mM 48 hrs, 4-day adult    48 Copper 0.5 mM 12 hrs, larvae L3    34 Copper 15 mM 48 hrs, 4-day adult    36 Zinc 5 mM 12 hrs, larvae L3    27 Zinc 4.5 mM 48 hrs, 4-day adult    46 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    25 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    47 Caffeine 25 mg/ml 48 hrs, 4-day adult    35 Paraquat 5 mM 48 hrs, 4-day adult    47 Paraquat 10 mM 48 hrs, 4-day adult    46 Rotenone 2 μg 12 hrs, larvae L3    27 Rotenone 8 μg 12 hrs, larvae L3    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_30 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015907 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG13425-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal (with blv5) blv6 lethal (with blv6) blv5 lethal | partially (with blv4) blv6 lethal | partially (with blv6) blv4 lethal | partially | recessive blv4 blv10 lethal | recessive blGTD74-310-1 blk08305 blunspecified blv6 viable bl176 blEY09813 viable, with Scer\GAL4pnr-MD237 blGD1382 viable (with blv1) blv2 viable (with blv2) blv1 Sterility Allele fertile blEY09813 Other Phenotypes Allele increased cell death blGMR.PC visible blGMR.PC visible, with Scer\GAL4ptc-559.1 blScer\UAS.cCa visible, with Scer\GAL4sca-537.4 blEP954 visible (with blk08305) blv5 visible (with blv1) blv2 visible (with blv2) blv1 visible (with blv5) blk08305 visible | pharate adult stage | recessive blk08305 wild-type blhs.PC Phenotype manifest in Allele 1st posterior cell, with Scer\GAL4ptc-559.1 blScer\UAS.cCa crossvein, with Scer\GAL4ptc-559.1 blScer\UAS.cCa eye blGMR.PC blv10 blv4 blv6 eye (with blv4) blv6 eye (with blv5) blv6 eye (with blv6) blv4 blv5 interommatidial bristle blGMR.PC leg blk08305 blv10 blv4 blv6 leg (with blk08305) blv5 leg (with blv1) blv2 leg (with blv2) blv1 leg (with blv4) blv6 leg (with blv5) blk08305 blv6 leg (with blv6) blv4 blv5 macrochaeta, with Scer\GAL4ptc-559.1 blEP954 macrochaeta, with Scer\GAL4sca-537.4 blEP954 metathoracic femur blk08305 metathoracic metatarsus blk08305 ommatidium blGMR.PC scutellar bristle | ectopic, with Scer\GAL4sca-537.4 blEP954 trichogen cell, with Scer\GAL4sca-537.4 blEP954 trichogen cell | ectopic, with Scer\GAL4sca-537.4 blEP954 wing blv10 blv4 blv6 wing, with Scer\GAL4ptc-559.1 blEP954 blScer\UAS.cCa wing (with blv1) blv2 wing (with blv2) blv1 wing (with blv4) blv6 wing (with blv5) blv6 wing (with blv6) blv4 blv5 wing disc blv6 wing disc, with Scer\GAL4ptc-559.1 blScer\UAS.cCa wing disc (with blv4) blv6 wing disc (with blv6) blv4 wing disc | posterior blGMR.PC
Classical Alleles ( 25 )
For All Classical Alleles Show
Allele of bl Class Mutagen Stocks Known lesion blc06384 piggyBac transposase 1 -- bld11391 1 -- ble00127 piggyBac transposase 1 -- ble01837 piggyBac transposase 1 -- ble02666 piggyBac transposase 1 -- blEY09813 P-element activity 1 -- blG13574 P-element activity 1 -- blk08305 P-element activity 1 Yes blKG02524 P-element activity 1 -- blMI03812 1 -- blNP3591 1 -- blNP7321 1 -- bl176 P-element activity 0 -- blCPTI002129 piggyBac transposase 0 Yes ble02185 piggyBac transposase 0 -- blEP954 P-element activity 0 Yes blGTD74-310-1 P-element activity 0 Yes blSH1899 0 -- blunspecified 0 -- blv10 P-element activity 0 Yes blv1 P-element activity 0 Yes blv2 P-element activity 0 Yes blv4 P-element activity 0 Yes blv5 P-element activity 0 Yes blv6 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of bl Class Mutagen Stocks Known lesion blGD1382 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes blHMJ02110 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes blKK106619 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes blGMR.PC in vitro construct - regulatory fusion 0 Yes blhs.PC in vitro construct - regulatory fusion 0 Yes blScer\UAS.cCa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel6070 (Ryder, 2004.4.26) Df(2R)Exel7164 (Ryder, 2004.4.26)
Partially disrupted in	Df(2R)mir-7-Δ1 (Li and Carthew, 2005)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1382} NA P{KK106619} NA P{TRiP.HMJ02110} NA P{UAS-bl.C} NA reporter construct P{bl-lacZ.CRM} No heat-shock construct P{hs-bl.C} NA characterization construct P{GMR-bl.C} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}blEP954 NA P{EP}blG13574 NA P{EPgy2}blEY09813 NA P{GSV1}C389C389 NA P{GSV1}GSd219GSd219 NA P{Mae-UAS.6.11}B1506B1506 NA P{Mae-UAS.6.11}B2033B2033 NA P{XP}bld11391 NA insertion of enhancer trap P{lacW}bl176 No P{lacW}blk08305 No P{lacW}blSH1899 No P{lacW}l(2)SH1068SH1068 No P{lacW}rigk07839 No P{lacW}rigk07917 No P{PZ}rig05056 No miscellaneous insertions Mi{MIC}blMI03812 NA P{GTD-b}blGTD74-310-1 NA P{SUPor-P}blKG02524 NA PBac{544.SVS-1}blCPTI002129 NA PBac{PB}blc06384 NA PBac{RB}ble00127 NA PBac{RB}ble01837 NA PBac{RB}ble02185 NA PBac{RB}ble02666 NA insertion of enhancer trap binary system P{GawB}blNP3591 No P{GawB}blNP7321 No
Gene Ontology: Function, Process & Cellular Component ( 13 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
regulation of alternative mRNA splicing, via spliceosome inferred from mutant phenotype (Park et al., 2004)
Cellular Component
CV term Evidence References
chromatin inferred from direct assay (Prasanth et al., 2000) nucleus inferred from direct assay (Prasanth et al., 2000) omega speckle inferred from direct assay (Prasanth et al., 2000)
Terms Based on Predictions or Assertions ( 10 terms )
Molecular Function
CV term Evidence References
mRNA binding non-traceable author statement (Hovemann, 1999.5.7) traceable author statement (Bomsztyk et al., 2004) RNA binding inferred from electronic annotation with InterPro:IPR004087, InterPro:IPR004088, InterPro:IPR018111 (FlyBase Curators et al., 2004-) transcription factor binding traceable author statement (Bomsztyk et al., 2004)
Biological Process
CV term Evidence References
appendage morphogenesis traceable author statement (Bomsztyk et al., 2004) cell fate commitment traceable author statement (Bomsztyk et al., 2004) cell proliferation traceable author statement (Bomsztyk et al., 2004) imaginal disc growth traceable author statement (Bomsztyk et al., 2004)
Cellular Component
CV term Evidence References
cytoplasm traceable author statement (Bomsztyk et al., 2004) nucleus inferred by curator from GO:0000381 (Park et al., 2004) traceable author statement (Bomsztyk et al., 2004) ribonucleoprotein complex inferred from sequence or structural similarity (Charroux et al., 1996, Buchenau et al., 1997, Gates and Thummel, 2000) inferred from sequence or structural similarity with human HNRNPK (FlyBase Genome Annotators, 2004)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
bl - BI-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) bl - CG2183 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) bl - CG3008 experimental knowledge based (Guruharsha et al., 2011) bl - CSN4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) bl - Cyp9b2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) bl - Glt experimental knowledge based (Guruharsha et al., 2011) bl - HnRNP-S5 anti bait coimmunoprecipitation, western blot (Hovemann et al., 2000) bl - Hrb87F anti bait coimmunoprecipitation, western blot (Hovemann et al., 2000) bl - Pep anti bait coimmunoprecipitation, western blot (Hovemann et al., 2000) bl - Pi3K68D experimental knowledge based (Guruharsha et al., 2011) bl - boca experimental knowledge based (Guruharsha et al., 2011) bl - l(1)G0193 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) bl - nej anti bait coimmunoprecipitation, western blot (Mallik and Lakhotia, 2010) bl - nonA anti bait coimmunoprecipitation, western blot (Hovemann et al., 2000)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions bl allele Gene References blEP954 N (Abdelilah-Seyfried et al., 2000) blGMR.PC BacA\p35 (Charroux et al., 1999)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68677 DroID - A comprehensive database of gene and protein interactions. • FBgn0015907 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43862
Orthologs
OrthoDB Orthologs (51) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6M92BR Dipteran inclusive ortholog search EOG6S1TH5 Insect inclusive ortholog search EOG6MSBVS Arthropod inclusive ortholog search EOG64J11M Metazoa inclusive ortholog search EOG6W9X03
Orthologs in Drosophila Species (EOG6M92BR)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\bl     Drosophila simulans   Dsim\GD11524 Y   Drosophila sechellia   Dsec\GM22026     Drosophila erecta   Dere\GG22043 Y   Drosophila yakuba   Dyak\GE12124 Y   Drosophila ananassae   Dana\GF12183 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA24337 Y   Drosophila persimilis   Dper\GL17034 Y   Drosophila willistoni   Dwil\GK21481 Y   Drosophila virilis   Dvir\GJ17213     Drosophila mojavensis   Dmoj\GI19683 Y   Drosophila grimshawi   Dgri\GH21981 Y
Orthologs in non-Drosophila Dipterans (EOG6S1TH5)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL014959   Anopheles gambiae Malaria mosquito  Agam\AGAP005015   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ000130
Orthologs in non-Dipteran Insects (EOG6MSBVS)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB42878   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG006521   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG006518   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH19804   Atta cephalotes Leafcutter ant  Acep\ACEP17441   Atta cephalotes Leafcutter ant  Acep\ACEP17444   Camponotus floridanus Florida carpenter ant  Cflo\CFLO15386   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL20764   Linepithema humile Argentine ant  Lhum\LH23812   Pogonomyrmex barbatus Red harvester ant  Pbar\PB24198   Pogonomyrmex barbatus Red harvester ant  Pbar\PB24197   Acyrthosiphon pisum Pea aphid  Apim\ACYPI010015   Bombyx mori Silkmoth  Bmor\BGIBMGA001953   Bombyx mori Silkmoth  Bmor\BGIBMGA001954   Pediculus humanus Human body louse  Phum\PHUM593000   Tribolium castaneum Red flour beetle  Tcas\TC009519
Orthologs in non-Insect Arthropods (EOG64J11M)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\COI   Ixodes scapularis Deer tick  Isca\ISCW001209   Ixodes scapularis Deer tick  Isca\ISCW009800
Orthologs in non-Arthropod Metazoa (EOG6W9X03)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\F26B1.2   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_027712gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_027713gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008011gn   Danio rerio Zebrafish  Drer\hnrnpk   Danio rerio Zebrafish  Drer\ENSDARG00000078787   Danio rerio Zebrafish  Drer\hnrpkl   Xenopus tropicalis Western clawed frog  Xtro\hnrnpk   Gallus gallus Domestic chicken  Ggal\ENSGALG00000014366   Gallus gallus Domestic chicken  Ggal\HNRNPK   Mus musculus House mouse  Mmus\Hnrnpk   Mus musculus House mouse  Mmus\Gm7964   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000029014   Rattus norvegicus Norway rat  Rnor\Hnrnpk   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000013016   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000006161   Homo sapiens Human  Hsap\HNRPK
Human Orthologs (1)
Gene OMIM HGNC Hsap\HNRPK
AAA Orthologs (9) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD11524 Drosophila erecta Dere\GG22043 Drosophila yakuba Dyak\GE12124 Drosophila ananassae Dana\GF12183 Drosophila pseudoobscura pseudoobscura Dpse\GA24337 Drosophila persimilis Dper\GL17034 Drosophila willistoni Dwil\GK21481 Drosophila mojavensis Dmoj\GI19683 Drosophila grimshawi Dgri\GH21981
Stocks & Reagents
Stocks Listed in FlyBase ( 15 )
Bloomington	29672 y1 w*; P{EP}blG13574 42540 y1 v1; P{TRiP.HMJ02110}attP40 37371 y1 w*; Mi{MIC}blMI03812 20053 y1 w67c23; P{EPgy2}blEY09813
Harvard	- P{XP}bld11391 - PBac{PB}blc06384 - PBac{RB}ble00127 - PBac{RB}ble01837 - PBac{RB}ble02666
Kyoto	104551 w*; P{GawB}blNP3591
VDRC	v105271 P{KK106619}VIE-260B v2912 w1118; P{GD1382}v2912
	More stocks available...
Genomic Clones ( 2 )
	BACR08P05 BACR33D17 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 99 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH20457 GM01586 LD45549 LP16172 RE05515 RE50346
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT21351 GH01268 GH18003 GM01520 GM02389 GM15943 HL01077 LD02606 LD05855 LD09459 LD15857 LD30547 LD36708 LD37459 LD42648 LP21552 RE01849 RE06481 RE08293 RE10343 RE11243 RE16758 RE16789 RE18508 RE18528 RE22777 RE27505 RE28777 RE31959 RE32231 RE34585 RE35985 RE55179 RE56562 RE56931 RE65756 RH71471 SD27179
Other clones	16173 43414 52845 59568 73356 74834 99594 108168 162662 214475.63 214537.74 274219 275556 558152 CK01.37B.D1 CK01.94A.C11 CK01.121C.C10 CK01.121C.G3 CK01.144C.C6 CK01.145A.G6 CK01.147B.B8 Dmel_neb_014186_0186_3361 Dmel_neb_015341_0430_2023 EC055218 EK055004 EK073310 EK092843 EK092926 EK119143 EK119259 EK120708 EK120740 EK127042 EK129319 EK162961 EK168860 EK184312 EK202449 EK204939 EK221961 EK244644 EK282605 EK301913 EK303054 EN13110 EP02218 EP09057 EP15609 FGM208F08 GH09851 GM13955 IP03368 RP004392591 RP004429471 RP004494622
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0015907 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43862
Antibody Information
	polyclonal (Charroux et al., 1999, Hovemann et al., 2000)
Other Information
Discoverer
Etymology
	The gene is named "bancal" (meaning "wobbly" in French) as mutant flies with a strong phenotype cannot walk and fall over. (Charroux et al., 1999)
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: bl CG13425 (Misra, 2000.4.8) Source for merge of: bl Hrb57A (Bayraktaroglu, 2000.5.26) Source for merge of: bl l(2)k08305 (Gates, 2000.3.3)
Additional comments
Other Comments
	The levels of bl protein affect cell proliferation and apoptosis in imaginal disc cells. (Charroux et al., 1999) bl is dynamically distributed in the nuclei of developing embryos and redistributed from the nucleus to cytoplasm at each mitosis from blastoderm to hatching. The protein is recruited to the 93D locus upon heat shock. (Buchenau et al., 1997)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_145883 NM_206183 NM_206184 NM_206185 NM_001169745 NM_001274173 RefSeq (Proteins) • NP_665890 NP_995905 NP_995906 NP_995907 NP_001163216 NP_001261102 DDBJ / EMBL / GenBank • AA803682 AAF00596 AAF57450 AAF78762 AAL39829 AAM68389 AAM68390 AAN71427 AAS64908 ACZ94488 AF142631 AF275629 AGB93634 AI389318 AI516680 AI518983 AI543885 AJ238947 AQ024999 AW943790 AY069684 BH900871 BI365117 BT001672 CAB64936 CL610257 CZ470648 CZ470649 CZ478025 CZ479660 CZ480010 CZ480442 Entrez Gene - A searchable database of RefSeq genes. • 43862 UniProtKB/TrEMBL • A1ZBW0 A1ZBW1 A1ZBW3 A1ZBW4 E1JGN7 Q7KA80 Q7KHL0 Q8IGP8 Q8SZZ6 Q9V948
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • K Homology domain (IPR004087) K Homology domain, type 1 (IPR004088)
Linkouts
	BioGRID - A database of protein and genetic interactions • 68677 DroID - A comprehensive database of gene and protein interactions. • FBgn0015907 DRSC - Results from RNAi screens. • FBgn0015907 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0015907 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG13425-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0015907 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43862 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43862 modMine - Data generated by the modENCODE project. • FBgn0015907 REDfly - A database of transcriptional regulatory elements. • FBgn0015907
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	bl (Li and Carthew, 2005, Sofola et al., 2007, Quinones-Coello, 2007, Molnar et al., 2006, Grieder et al., 2007, Minidorff et al., 2007, Minidorff et al., 2007, Pek et al., 2009, Chen et al., 2008, McIntyre et al., 2006, Buffin and Gho, 2010, Wasbrough et al., 2010, He et al., 2012, Siddiqui et al., 2012) BL (Sofola et al., 2007) CG13425 (Quinones-Coello, 2007, Molnar et al., 2006, Grieder et al., 2007, O'Keefe et al., 2011, Keleman et al., 2009.8.5, Chen et al., 2008, McIntyre et al., 2006, Ni et al., 2010.12.1) dhnRNP K (Gortchakov et al., 2005) Hrb57A (Marhold et al., 2002, Zimowska and Paddy, 2002, Rajendra et al., 2001, Gasser, 2002, Prasanth et al., 2000, Bayraktaroglu, 2000.5.26, Hovemann, 1999.5.7, Zink and Cremer, 1998, Buchenau et al., 1998, Buchenau et al., 1997, Gortchakov et al., 2005, Mallik and Lakhotia, 2009, Mallik and Lakhotia, 2010) l(2)k08305 (Gates and Thummel, 2000) Q18 (Hovemann et al., 2000, Lakhotia et al., 1999) unnamed (Gates and Thummel, 2000)
Name Synonym	bancal (Charroux, 1999.4.13, Charroux et al., 1996, Venken, 2006, Venken et al., 2006, Robida et al., 2007, Ochoa-Espinosa et al., 2009, Pek et al., 2009, Buffin and Gho, 2010) Bancal (O'Keefe et al., 2011, Garcia and Stathopoulos, 2011) Heterogeneous nuclear ribonucleoprotein at 57A (Buchenau et al., 1997)
Secondary FlyBase IDs
	FBgn0010589 FBgn0020651 FBgn0034524 FBgn0050153
References ( 80 )
Generate a list of	All references relating to this gene ( 80 )
List References by type	Research paper  ( 39 ) Supplementary material  ( 11 ) Review  ( 4 ) Personal communication to FlyBase  ( 18 ) Abstract  ( 2 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 2 )
Recent research papers ( 6 )
	He et al., 2012, Mol. Biol. Evol. 29(3): 1059--1070 Evolutionary origins of transcription factor binding site clusters. [FBrf0217421] Krauchunas et al., 2012, Dev. Biol. 370(1): 125--134 Protein phosphorylation changes reveal new candidates in the regulation of egg activation and early embryogenesis in D. melanogaster. [FBrf0219342] Siddiqui et al., 2012, Genome Biol. 13(2): R11 Genome-wide analysis of the maternal-to-zygotic transition in Drosophila primordial germ cells. [FBrf0218847] Ambegaokar and Jackson, 2011, Hum. Mol. Genet. 20(24): 4947--4977 Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation. [FBrf0217690] Garcia and Stathopoulos, 2011, PLoS ONE 6(12): e29172 Lateral gene expression in Drosophila early embryos is supported by grainyhead-mediated activation and tiers of dorsally-localized repression. [FBrf0217082] O'Keefe et al., 2011, Hum. Mol. Genet. 20(3): 497--509 Drosophila orthologue of WWOX, the chromosomal fragile site FRA16D tumour suppressor gene, functions in aerobic metabolism and regulates reactive oxygen species. [FBrf0212691] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...