FB2020_06, released Dec 22, 2020

Gene: Dmel\lama

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General Information
Symbol
Dmel\lama
Species
D. melanogaster
Name
lamina ancestor
Annotation Symbol
CG10645
Feature Type
protein_coding_gene
FlyBase ID
FBgn0016031
Gene Model Status
Current
Stock Availability
16 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Key Links
Genomic Location
Cytogenetic map
64C12-64C13
Sequence location
3L:5,343,619..5,355,923 [-]
Recombination map

3-13

RefSeq locus
NT_037436 REGION:5343619..5355923
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (5 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables phospholipase activity
inferred from biological aspect of ancestor with PANTHER:PTN000271481
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in dorsal appendage formation
inferred from mutant phenotype
(Peters et al., 2013)
involved_in imaginal disc development
inferred from mutant phenotype
(assigned by UniProt )
(Klebes et al., 2005)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in phospholipid catabolic process
inferred from biological aspect of ancestor with PANTHER:PTN000271481
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in extracellular region
inferred from direct assay
(assigned by UniProt )
(Klebes et al., 2005)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in extracellular region
inferred from biological aspect of ancestor with PANTHER:PTN000271481
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the phospholipase B-like family. (Q9VRK8)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
OTHER CARBOXYLESTERASES -
OTHER CARBOXYLESTERASES are carboxylesterases that do not fall into any other major carboxylesterase group.
Protein Function (UniProtKB)
Putative phospholipase (By similarity). Involved in the regulation of cellular plasticity in imaginal disks.
(UniProt, Q9VRK8)
Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\lama for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.46

Gene model reviewed during 5.56

gene_with_dicistronic_mRNA ; SO:0000722

Gene model reviewed during 6.32

Sequence Ontology: Class of Gene
gene_with_dicistronic_mRNA
(FlyBase Genome Annotators, 2020)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
lama-RA
FBtr0077161
NM_168115
2975
658
lama-RB
FBtr0077160
NM_079209
3546
658
lama-RC
FBtr0077159
NM_168116
3044
658
lama-RD
FBtr0333595
NM_001274511
3655
658
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
lama-PA
FBpp0076864
74.9
658
5.62
NP_729059
AAG22333
lama-PB
FBpp0076863
74.9
658
5.62
NP_523933
AAF50787
lama-PC
FBpp0076862
74.9
658
5.62
NP_729060
AAN12118
lama-PD
FBpp0305772
74.9
658
5.62
NP_001261440
AGB94135
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

658 aa isoforms: lama-PA, lama-PB, lama-PC, lama-PD
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\lama using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in extracellular region
inferred from direct assay
(assigned by UniProt )
(Klebes et al., 2005)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\lama in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 34 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of lama
Transgenic constructs containing regulatory region of lama
Deletions and Duplications ( 1 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\PLBD2
12 of 15
Yes
Yes
Hsap\PLBD1
8 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Plbd2
11 of 15
Yes
Yes
Mmus\Plbd1
8 of 15
No
Yes
Rattus norvegicus (Norway rat) (2)
Rnor\Plbd2
11 of 13
Yes
Yes
Rnor\Plbd1
7 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\plbd2
6 of 12
Yes
Yes
Danio rerio (Zebrafish) (3)
Drer\plbd1
5 of 15
Yes
Yes
Drer\si:ch73-139e5.2
5 of 15
Yes
Yes
Drer\zgc:158619
5 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (3)
Cele\F09B12.3
11 of 15
Yes
Yes
Cele\Y37D8A.2
11 of 15
Yes
Yes
Cele\Y54F10AM.8
11 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091903LB )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00003644
Drosophila simulans
Dsim\GD13205
Drosophila sechellia
Dsec\GM13926
Drosophila erecta
Dere\GG14138
Drosophila yakuba
Dyak\GE20567
Drosophila ananassae
Dana\GF10469
Drosophila pseudoobscura pseudoobscura
Dpse\GA10464
Drosophila persimilis
Dper\GL12181
Drosophila willistoni
Dwil\GK17322
Drosophila virilis
Dvir\lama
Drosophila mojavensis
Dmoj\GI11981
Drosophila grimshawi
Dgri\GH15272
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915048G )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17007981
Glossina morsitans
Tsetse fly
Gmor\GMOY001192
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_14529
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL007092
Anopheles darlingi
American malaria mosquito
Adar\ADAC007434
Anopheles gambiae
Malaria mosquito
Agam\AGAP005971
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ008975
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0AEZ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA005418
Danaus plexippus
Monarch butterfly
Dple\DPOGS201663-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL010116
Heliconius melpomene
Postman butterfly
Hmel\HMEL011933
Apis florea
Little honeybee
Aflo\2713788580
Apis mellifera
Western honey bee
Amel\LOC410007
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP17300
Bombus terrestris
Buff-tailed bumblebee
Bter\15210379
Linepithema humile
Argentine ant
Lhum\LH10385
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0016bb
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG012707
Pediculus humanus
Human body louse
Phum\PHUM138490
Cimex lectularius
Bed bug
Clec\CLEC003939
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI003513
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004915
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006814
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_02145
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_02136
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0ABI )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR001176
Ixodes scapularis
Black-legged tick
Isca\ISCW014852
Ixodes scapularis
Black-legged tick
Isca\ISCW020185
Ixodes scapularis
Black-legged tick
Isca\ISCW012107
Ixodes scapularis
Black-legged tick
Isca\ISCW009471
Ixodes scapularis
Black-legged tick
Isca\ISCW012109
Ixodes scapularis
Black-legged tick
Isca\ISCW012112
Ixodes scapularis
Black-legged tick
Isca\ISCW012113
Ixodes scapularis
Black-legged tick
Isca\ISCW012114
Ixodes scapularis
Black-legged tick
Isca\ISCW012105
Ixodes scapularis
Black-legged tick
Isca\ISCW006704
Ixodes scapularis
Black-legged tick
Isca\ISCW007955
Stegodyphus mimosarum
African social velvet spider
Smim\KFM70112.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM70110.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM83543.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g04850
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g02180
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g04820
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g02170
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_213420
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0G9H )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-PbL1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_011019gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_018690gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-P76
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000007228
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000005481
Gallus gallus
Domestic chicken
Ggal\PLBD1
Gallus gallus
Domestic chicken
Ggal\LOC417031
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    PLBD2; phospholipase B domain containing 2
    12 of 15
        PLBD1; phospholipase B domain containing 1
        8 of 15
        618486
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            esyN Network Diagram
            Interactions Browser
            Summary of Genetic Interactions
            esyN Network Diagram
            esyN Network Key:
            Suppression
            Enhancement
            View in Interactions Browser
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            lama
            enhanceable
            ttk
            (Peters et al., 2013)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            External Data
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            External Data
            Linkouts
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            3L
            Recombination map

            3-13

            Cytogenetic map
            64C12-64C13
            Sequence location
            3L:5,343,619..5,355,923 [-]
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            64C12-64C13
            Limits computationally determined from genome sequence between P{PZ}l(3)rG166rG166 and P{PZ}sinu06524
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            64C11-64C11
            (Perez, 1996.4.30)
            64C11-64C11
            (determined by in situ hybridisation)
            (Perez and Steller, 1996)
            Experimentally Determined Recombination Data
            Location

            3-13

            (FlyBase, 2016)

            3-13.0

            (Comeron et al., 2012)

            3-

            (Perez, 1996.4.30)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (16)
            Genomic Clones (26)
            cDNA Clones (51)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            DRSC - Results frm RNAi screens
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            Antibody Information
            Laboratory Generated Antibodies
             
            Commercially Available Antibodies
             
            Other Information
            Relationship to Other Genes
            Source for database identify of

            Source for identity of: lama CG10645

            (Gabrielian, 1999.11)
            Source for database merge of
            Additional comments

            One or more of the processed transcripts for this gene contain(s) two non-overlapping open reading frames (ORFs). The non-overlapping ORFs are represented by lama and CG46456.

            (FlyBase Genome Annotators, 2020)
            Other Comments

            lama has been cloned and sequenced, and its expression pattern has been analysed.

            (Perez and Steller, 1996)
            Origin and Etymology
            Discoverer
            Etymology

            The gene is named 'lamina ancestor' ('lama') as it is expressed in both the neuronal and glial precursors of the lamina.

            (Perez and Steller, 1996)
            Identification
            External Crossreferences and Linkouts ( 52 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            Flygut - An atlas of the Drosophila adult midgut
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            modMine - A data warehouse for the modENCODE project
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            FLIGHT - Cell culture data for RNAi and other high-throughput technologies
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            FlyMine - An integrated database for Drosophila genomics
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Synonyms and Secondary IDs (3)
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            References (57)