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Gene Dmel\lbm

General Information
Symbol	Dmel\lbm	Species	D. melanogaster
Name	late bloomer	Annotation symbol	CG2374
Feature type	protein_coding_gene	FlyBase ID	FBgn0016032
Gene Model Status	Current	Stock availability	10 publicly available
Also Known As	lbl
Genomic Location
Chromosome (arm)	2R	Recombination map	2-
Cytogenetic map	42E6-42E6	Sequence location	2R:2,936,743..2,939,469 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene late bloomer is referred to in FlyBase by the symbol Dmel\lbm (CG2374, FBgn0016032). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: synapse assembly. 13 alleles are reported. The phenotypes of these alleles are annotated with: RP3 motor neuron; growth cone; synapse; presynaptic ribbon. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Tetraspanin, EC2 domain; Tetraspanin/Peripherin. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 12-24 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult thoracico-abdominal ganglion, adult crop, adult hindgut, adult heart, larval fat body, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1639406_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of lbm. Gene sequence location is 2R:2936743..2939469.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03	Controlled Vocabulary Terms A1-7 LL1 motor neuron A1-7 DO2 motor neuron
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 42E6-42E6   Limits computationally determined from genome sequence between P{lacW}vimark16722 and P{lacW}cosk16101
Experimentally Determined Cytological Location
Cytogenetic map Notes References 42F1-42F1     (Kopczynski, 1996.2.12)
Experimentally Determined Recombination Data
Location	2- (Kopczynski, 1996.2.12)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\lbm for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.48
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) lbm-RA FBtr0089033  NM_078915   1029   208 lbm-RB FBtr0336873  NM_001273828   923   208
Additional Transcript Data & Comments
Reported size (kB)	1.0 (longest cDNA) (Kopczynski et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein lbm-PA   FBpp0088104   23.0   208   4.62     NP_523639   AAF59302 lbm-PB   FBpp0307822   23.0   208   4.62     NP_001260757   AGB93290
Additional Polypeptide Data & Comments
Reported size (kDa)	208 (aa) (Kopczynski et al., 1996)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Tetraspanin/Peripherin (IPR018499) Tetraspanin, EC2 domain (IPR008952)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF59302   AE013599 AGB93290   AY071541 AAL49163   BI371037   BI374149   BI614738   BI615105   BP547416   BP548204   BP548375   CO280551   CO297427   CO316783   CZ468001   CZ472384   EC075853   EC199363   EC219437   EC229240   EC238504   U49081 AAA98512
UniProtKB/Swiss-Prot	Q24188
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 11 -- 12   central brain primordium   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   dorsal sensory complex proper primordium   (Fisher et al., 2012) Comment:reported as dorsal/lateral sensory complexes embryonic brain   (Fisher et al., 2012) embryonic dorsal epidermis   (Fisher et al., 2012) embryonic head sensory system   (Fisher et al., 2012) embryonic ventral epidermis   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) sensory nervous system primordium   (Fisher et al., 2012) ventral midline   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) ventral sensory complex primordium   (Fisher et al., 2012) embryonic stage 14   RP neuron   (Kopczynski et al., 1996) VUM neuron   (Kopczynski et al., 1996) U neuron   (Kopczynski et al., 1996) aCC neuron   (Kopczynski et al., 1996)
Additional Descriptive Data
	lbm is expressed specifically by motor neurons, such as aCC, RP1-RP5, the three U neurons, and the VUM neurons. It is also expressed transiently and at lower levels in some peripheral sensory neurons. (Kopczynski et al., 1996)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 16   motor neuron   • axon (Kopczynski et al., 1996)
Additional Descriptive Data
	lbm protein, a cell surface protein, is transiently expressed along the entire length of motor axons, including their growth cones and presynaptic terminals. The protein is present in late embryogenesis,but disappears by third larval instar. (Kopczynski et al., 1996)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
extracellular region inferred from direct assay AND inferred from sequence or structural similarity (Kopczynski et al., 1996)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult thoracico-abdominal ganglion, adult crop, adult hindgut, adult heart, larval fat body, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    46.425 Larval Midgut    68.3 Larval Hindgut    94 Larval Malpighian Tubules    31.8 Larval Fat Body    118 Larval Salivary Gland    15 Larval Trachea    65.7 Larval Carcass    194.85 Adult Head    77.4 Adult Eye    44.9 Adult Brain    30 Adult Thoracic-Abdominal Ganglion    112.7 Adult Crop    426.4 Adult Midgut    77.2 Adult Hindgut    242.8 Adult Malpighian Tubules    17.1 Adult Fat Body    49.2 Adult Salivary Gland    31.6 Adult Heart    211.65 Adult VirginFemale Spermatheca    48.3 Adult InseminatedFemale Spermatheca    62.2 Adult Ovary    2.8 Adult Testis    11.2 Adult Male Accessory Gland    13.5 Adult Carcass    119.8 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    46.425 Larval Midgut    68.3 Larval Hindgut    94 Larval Malpighian Tubules    31.8 Larval Fat Body    118 Larval Salivary Gland    15 Larval Trachea    65.7 Larval Carcass    194.85 Adult Head    77.4 Adult Eye    44.9 Adult Brain    30 Adult Thoracic-Abdominal Ganglion    112.7 Adult Crop    426.4 Adult Midgut    77.2 Adult Hindgut    242.8 Adult Malpighian Tubules    17.1 Adult Fat Body    49.2 Adult Salivary Gland    31.6 Adult Heart    211.65 Adult VirginFemale Spermatheca    48.3 Adult InseminatedFemale Spermatheca    62.2 Adult Ovary    2.8 Adult Testis    11.2 Adult Male Accessory Gland    13.5 Adult Carcass    119.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    46.425 Larval Midgut    68.3 Larval Hindgut    94 Larval Malpighian Tubules    31.8 Larval Fat Body    118 Larval Salivary Gland    15 Larval Trachea    65.7 Larval Carcass    194.85 Adult Head    77.4 Adult Eye    44.9 Adult Brain    30 Adult Thoracic-Abdominal Ganglion    112.7 Adult Crop    426.4 Adult Midgut    77.2 Adult Hindgut    242.8 Adult Malpighian Tubules    17.1 Adult Fat Body    49.2 Adult Salivary Gland    31.6 Adult Heart    211.65 Adult VirginFemale Spermatheca    48.3 Adult InseminatedFemale Spermatheca    62.2 Adult Ovary    2.8 Adult Testis    11.2 Adult Male Accessory Gland    13.5 Adult Carcass    119.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    46.425 Larval Midgut    68.3 Larval Hindgut    94 Larval Malpighian Tubules    31.8 Larval Fat Body    118 Larval Salivary Gland    15 Larval Trachea    65.7 Larval Carcass    194.85 Adult Head    77.4 Adult Eye    44.9 Adult Brain    30 Adult Thoracic-Abdominal Ganglion    112.7 Adult Crop    426.4 Adult Midgut    77.2 Adult Hindgut    242.8 Adult Malpighian Tubules    17.1 Adult Fat Body    49.2 Adult Salivary Gland    31.6 Adult Heart    211.65 Adult VirginFemale Spermatheca    48.3 Adult InseminatedFemale Spermatheca    62.2 Adult Ovary    2.8 Adult Testis    11.2 Adult Male Accessory Gland    13.5 Adult Carcass    119.8 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    46.425 Larval Midgut    68.3 Larval Hindgut    94 Larval Malpighian Tubules    31.8 Larval Fat Body    118 Larval Salivary Gland    15 Larval Trachea    65.7 Larval Carcass    194.85 Adult Head    77.4 Adult Eye    44.9 Adult Brain    30 Adult Thoracic-Abdominal Ganglion    112.7 Adult Crop    426.4 Adult Midgut    77.2 Adult Hindgut    242.8 Adult Malpighian Tubules    17.1 Adult Fat Body    49.2 Adult Salivary Gland    31.6 Adult Heart    211.65 Adult VirginFemale Spermatheca    48.3 Adult InseminatedFemale Spermatheca    62.2 Adult Ovary    2.8 Adult Testis    11.2 Adult Male Accessory Gland    13.5 Adult Carcass    119.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    46.425 Larval Midgut    68.3 Larval Hindgut    94 Larval Malpighian Tubules    31.8 Larval Fat Body    118 Larval Salivary Gland    15 Larval Trachea    65.7 Larval Carcass    194.85 Adult Head    77.4 Adult Eye    44.9 Adult Brain    30 Adult Thoracic-Abdominal Ganglion    112.7 Adult Crop    426.4 Adult Midgut    77.2 Adult Hindgut    242.8 Adult Malpighian Tubules    17.1 Adult Fat Body    49.2 Adult Salivary Gland    31.6 Adult Heart    211.65 Adult VirginFemale Spermatheca    48.3 Adult InseminatedFemale Spermatheca    62.2 Adult Ovary    2.8 Adult Testis    11.2 Adult Male Accessory Gland    13.5 Adult Carcass    119.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    46.425 Larval Midgut    68.3 Larval Hindgut    94 Larval Malpighian Tubules    31.8 Larval Fat Body    118 Larval Salivary Gland    15 Larval Trachea    65.7 Larval Carcass    194.85 Adult Head    77.4 Adult Eye    44.9 Adult Brain    30 Adult Thoracic-Abdominal Ganglion    112.7 Adult Crop    426.4 Adult Midgut    77.2 Adult Hindgut    242.8 Adult Malpighian Tubules    17.1 Adult Fat Body    49.2 Adult Salivary Gland    31.6 Adult Heart    211.65 Adult VirginFemale Spermatheca    48.3 Adult InseminatedFemale Spermatheca    62.2 Adult Ovary    2.8 Adult Testis    11.2 Adult Male Accessory Gland    13.5 Adult Carcass    119.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    46.425 Larval Midgut    68.3 Larval Hindgut    94 Larval Malpighian Tubules    31.8 Larval Fat Body    118 Larval Salivary Gland    15 Larval Trachea    65.7 Larval Carcass    194.85 Adult Head    77.4 Adult Eye    44.9 Adult Brain    30 Adult Thoracic-Abdominal Ganglion    112.7 Adult Crop    426.4 Adult Midgut    77.2 Adult Hindgut    242.8 Adult Malpighian Tubules    17.1 Adult Fat Body    49.2 Adult Salivary Gland    31.6 Adult Heart    211.65 Adult VirginFemale Spermatheca    48.3 Adult InseminatedFemale Spermatheca    62.2 Adult Ovary    2.8 Adult Testis    11.2 Adult Male Accessory Gland    13.5 Adult Carcass    119.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    77.4   NA  Eye    44.9   NA  Brain    30   46.425  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    112.7   NA  Crop    426.4   68.3  Midgut    77.2   94  Hindgut    242.8   31.8  Malpighian Tubules    no informative data   118  Fat Body    49.2   no informative data  Salivary Gland    no informative data   NA  Heart    211.65   65.7  Trachea    NA   NA  VirginFemale Spermatheca    48.3   NA  InseminatedFemale Spermatheca    62.2   NA  Ovary    2.8   NA  Testis    no informative data   NA  Male Accessory Gland    no informative data   194.85  Carcass    119.8 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    3 central nervous system, pupae P8    1 head, virgin 1-day female    3 head, virgin 4-day female    2 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    2 head, mated 1-day male    4 head, mated 4-day male    3 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    2 digestive system, 4-day adult    1 digestive system, 20-day adult    2 fat body, larvae L3 wandering    3 fat body, white prepupae    2 fat body, pupae P8    1 carcass, larvae L3 wandering    11 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    3 central nervous system, pupae P8    1 head, virgin 1-day female    3 head, virgin 4-day female    2 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    2 head, mated 1-day male    4 head, mated 4-day male    3 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    2 digestive system, 4-day adult    1 digestive system, 20-day adult    2 fat body, larvae L3 wandering    3 fat body, white prepupae    2 fat body, pupae P8    1 carcass, larvae L3 wandering    11 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    3 central nervous system, pupae P8    1 head, virgin 1-day female    3 head, virgin 4-day female    2 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    2 head, mated 1-day male    4 head, mated 4-day male    3 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    2 digestive system, 4-day adult    1 digestive system, 20-day adult    2 fat body, larvae L3 wandering    3 fat body, white prepupae    2 fat body, pupae P8    1 carcass, larvae L3 wandering    11 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    3 central nervous system, pupae P8    1 head, virgin 1-day female    3 head, virgin 4-day female    2 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    2 head, mated 1-day male    4 head, mated 4-day male    3 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    2 digestive system, 4-day adult    1 digestive system, 20-day adult    2 fat body, larvae L3 wandering    3 fat body, white prepupae    2 fat body, pupae P8    1 carcass, larvae L3 wandering    11 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    3 central nervous system, pupae P8    1 head, virgin 1-day female    3 head, virgin 4-day female    2 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    2 head, mated 1-day male    4 head, mated 4-day male    3 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    2 digestive system, 4-day adult    1 digestive system, 20-day adult    2 fat body, larvae L3 wandering    3 fat body, white prepupae    2 fat body, pupae P8    1 carcass, larvae L3 wandering    11 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    3 central nervous system, pupae P8    1 head, virgin 1-day female    3 head, virgin 4-day female    2 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    2 head, mated 1-day male    4 head, mated 4-day male    3 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    2 digestive system, 4-day adult    1 digestive system, 20-day adult    2 fat body, larvae L3 wandering    3 fat body, white prepupae    2 fat body, pupae P8    1 carcass, larvae L3 wandering    11 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    3 central nervous system, pupae P8    1 head, virgin 1-day female    3 head, virgin 4-day female    2 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    2 head, mated 1-day male    4 head, mated 4-day male    3 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    2 digestive system, 4-day adult    1 digestive system, 20-day adult    2 fat body, larvae L3 wandering    3 fat body, white prepupae    2 fat body, pupae P8    1 carcass, larvae L3 wandering    11 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    3 central nervous system, pupae P8    1 head, virgin 1-day female    3 head, virgin 4-day female    2 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    2 head, mated 1-day male    4 head, mated 4-day male    3 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    2 digestive system, 4-day adult    1 digestive system, 20-day adult    2 fat body, larvae L3 wandering    3 fat body, white prepupae    2 fat body, pupae P8    1 carcass, larvae L3 wandering    11 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 12-24 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    4 embryo 08-10hr    9 embryo 10-12hr    48 embryo 12-14hr    48 embryo 14-16hr    80 embryo 16-18hr    91 embryo 18-20hr    82 embryo 20-22hr    45 embryo 22-24hr    46 larva L1    15 larva L2    5 larva L3 12hr old    4 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    30 white prepupae new    17 white prepupae 12hr    15 white prepupae 24hr    5 pupae 2d postWPP    4 pupae 3d postWPP    9 pupae 4d postWPP    21 adult male 01day    15 adult male 05day    17 adult male 30day    17 adult female 01day    9 adult female 05day    4 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    4 embryo 08-10hr    9 embryo 10-12hr  (48) embryo 12-14hr  (48) embryo 14-16hr  (80) embryo 16-18hr  (91) embryo 18-20hr  (82) embryo 20-22hr  (45) embryo 22-24hr  (46) larva L1    15 larva L2    5 larva L3 12hr old    4 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9  (30) white prepupae new    17 white prepupae 12hr    15 white prepupae 24hr    5 pupae 2d postWPP    4 pupae 3d postWPP    9 pupae 4d postWPP    21 adult male 01day    15 adult male 05day    17 adult male 30day    17 adult female 01day    9 adult female 05day    4 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    4 embryo 08-10hr    9 embryo 10-12hr    48 embryo 12-14hr    48 embryo 14-16hr    80 embryo 16-18hr    91 embryo 18-20hr    82 embryo 20-22hr    45 embryo 22-24hr    46 larva L1    15 larva L2    5 larva L3 12hr old    4 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    30 white prepupae new    17 white prepupae 12hr    15 white prepupae 24hr    5 pupae 2d postWPP    4 pupae 3d postWPP    9 pupae 4d postWPP    21 adult male 01day    15 adult male 05day    17 adult male 30day    17 adult female 01day    9 adult female 05day    4 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    4 embryo 08-10hr    9 embryo 10-12hr    48 embryo 12-14hr    48 embryo 14-16hr    80 embryo 16-18hr    91 embryo 18-20hr    82 embryo 20-22hr    45 embryo 22-24hr    46 larva L1    15 larva L2    5 larva L3 12hr old    4 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    30 white prepupae new    17 white prepupae 12hr    15 white prepupae 24hr    5 pupae 2d postWPP    4 pupae 3d postWPP    9 pupae 4d postWPP    21 adult male 01day    15 adult male 05day    17 adult male 30day    17 adult female 01day    9 adult female 05day    4 adult female 30day    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    4 embryo 08-10hr    9 embryo 10-12hr    48 embryo 12-14hr    48 embryo 14-16hr    80 embryo 16-18hr    91 embryo 18-20hr    82 embryo 20-22hr    45 embryo 22-24hr    46 larva L1    15 larva L2    5 larva L3 12hr old    4 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    30 white prepupae new    17 white prepupae 12hr    15 white prepupae 24hr    5 pupae 2d postWPP    4 pupae 3d postWPP    9 pupae 4d postWPP    21 adult male 01day    15 adult male 05day    17 adult male 30day    17 adult female 01day    9 adult female 05day    4 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    4 embryo 08-10hr    9 embryo 10-12hr  (48) embryo 12-14hr  (48) embryo 14-16hr  (80) embryo 16-18hr  (91) embryo 18-20hr  (82) embryo 20-22hr  (45) embryo 22-24hr  (46) larva L1    15 larva L2    5 larva L3 12hr old    4 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9  30 white prepupae new    17 white prepupae 12hr    15 white prepupae 24hr    5 pupae 2d postWPP    4 pupae 3d postWPP    9 pupae 4d postWPP    21 adult male 01day    15 adult male 05day    17 adult male 30day    17 adult female 01day    9 adult female 05day    4 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    4 embryo 08-10hr    9 embryo 10-12hr    48 embryo 12-14hr    48 embryo 14-16hr    80 embryo 16-18hr    91 embryo 18-20hr    82 embryo 20-22hr    45 embryo 22-24hr    46 larva L1    15 larva L2    5 larva L3 12hr old    4 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    30 white prepupae new    17 white prepupae 12hr    15 white prepupae 24hr    5 pupae 2d postWPP    4 pupae 3d postWPP    9 pupae 4d postWPP    21 adult male 01day    15 adult male 05day    17 adult male 30day    17 adult female 01day    9 adult female 05day    4 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    4 embryo 08-10hr    9 embryo 10-12hr    48 embryo 12-14hr    48 embryo 14-16hr    80 embryo 16-18hr    91 embryo 18-20hr    82 embryo 20-22hr    45 embryo 22-24hr    46 larva L1    15 larva L2    5 larva L3 12hr old    4 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    30 white prepupae new    17 white prepupae 12hr    15 white prepupae 24hr    5 pupae 2d postWPP    4 pupae 3d postWPP    9 pupae 4d postWPP    21 adult male 01day    15 adult male 05day    17 adult male 30day    17 adult female 01day    9 adult female 05day    4 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    7 Schneider line 2 Sg4    8 embryonic 1182-4H    7 embryonic GM2    1 embryonic Kc167    7 embryonic S1    0 embryonic S3    2 leg disc CME L1    4 wing disc CME-W2    1 wing disc ML-DmD8    2 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    3 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    2 ovary fGS/OSS    1 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    7 Schneider line 2 Sg4    8 embryonic 1182-4H    7 embryonic GM2    1 embryonic Kc167    7 embryonic S1    0 embryonic S3    2 leg disc CME L1    4 wing disc CME-W2    1 wing disc ML-DmD8    2 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    3 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    2 ovary fGS/OSS    1 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    7 Schneider line 2 Sg4    8 embryonic 1182-4H    7 embryonic GM2    1 embryonic Kc167    7 embryonic S1    0 embryonic S3    2 leg disc CME L1    4 wing disc CME-W2    1 wing disc ML-DmD8    2 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    3 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    2 ovary fGS/OSS    1 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    7 Schneider line 2 Sg4    8 embryonic 1182-4H    7 embryonic GM2    1 embryonic Kc167    7 embryonic S1    0 embryonic S3    2 leg disc CME L1    4 wing disc CME-W2    1 wing disc ML-DmD8    2 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    3 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    2 ovary fGS/OSS    1 ovary OSC    0 ovary OSS    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    7 Schneider line 2 Sg4    8 embryonic 1182-4H    7 embryonic GM2    1 embryonic Kc167    7 embryonic S1    0 embryonic S3    2 leg disc CME L1    4 wing disc CME-W2    1 wing disc ML-DmD8    2 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    3 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    2 ovary fGS/OSS    1 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    7 Schneider line 2 Sg4    8 embryonic 1182-4H    7 embryonic GM2    1 embryonic Kc167    7 embryonic S1    0 embryonic S3    2 leg disc CME L1    4 wing disc CME-W2    1 wing disc ML-DmD8    2 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    3 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    2 ovary fGS/OSS    1 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    7 Schneider line 2 Sg4    8 embryonic 1182-4H    7 embryonic GM2    1 embryonic Kc167    7 embryonic S1    0 embryonic S3    2 leg disc CME L1    4 wing disc CME-W2    1 wing disc ML-DmD8    2 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    3 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    2 ovary fGS/OSS    1 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    7 Schneider line 2 Sg4    8 embryonic 1182-4H    7 embryonic GM2    1 embryonic Kc167    7 embryonic S1    0 embryonic S3    2 leg disc CME L1    4 wing disc CME-W2    1 wing disc ML-DmD8    2 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    3 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    2 ovary fGS/OSS    1 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_29
External Data & Images
Linkouts	BDGP expression data • RE57845 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0016032 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2374-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for lbm Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 lbmGD1843 Other Phenotypes Allele neuroanatomy defective lbmY13 neuroanatomy defective, with Scer\GAL4elav-C155 lbmEY02692 neuroanatomy defective | embryonic stage lbmY13 Phenotype manifest in Allele growth cone lbmY13 presynaptic ribbon lbmY13 RP3 motor neuron lbmS64 lbmY13 RP3 neuron & synapse lbmY13 synapse lbmY13 synapse, with Scer\GAL4elav-C155 lbmEY02692
Classical Alleles ( 9 )
For All Classical Alleles Show
Allele of lbm Class Mutagen Stocks Known lesion lbmc01253 1 -- lbmc02514 piggyBac transposase 1 -- lbmd01697 P-element activity 1 -- lbmEY02692 P-element activity 1 -- lbmMI01271 1 -- lbmS64 Delta2-3 0 Yes lbmTET19 P-element activity 0 Yes lbmTET27 P-element activity 0 Yes lbmY13 Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of lbm Class Mutagen Stocks Known lesion lbmGD1843 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes lbmGL00385 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes lbmJF02589 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes lbmKK112318 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel6283 (Ryder, 2004.4.26) Df(2R)Δ42E (Lin et al., 2005)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1843} NA P{KK112318} NA P{TRiP.GL00385} NA P{TRiP.JF02589} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}lbmMI01271 NA P{GT1}BG02848 NA PBac{PB}lbmc01253 NA PBac{PB}lbmc02514 NA insertion of mobile activating element P{EPgy2}lbmEY02692 NA P{XP}lbmd01697 NA insertion of enhancer trap P{lacZ-un3}lbmS64 No P{lacZ-un3}lbmY13 No
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
synapse assembly inferred from mutant phenotype (Kopczynski et al., 1996)
Cellular Component
CV term Evidence References
extracellular region inferred from direct assay AND inferred from sequence or structural similarity (Kopczynski et al., 1996)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
synapse assembly non-traceable author statement (Swiss-Prot Project Members, 1997.2.1)
Cellular Component
CV term Evidence References
integral to membrane inferred from electronic annotation with InterPro:IPR008952, InterPro:IPR018499 (FlyBase Curators et al., 2004-) inferred from sequence model (Fradkin et al., 2002) inferred from sequence or structural similarity (Todres et al., 2000) non-traceable author statement (Swiss-Prot Project Members, 1997.2.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions lbm allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0016032
Orthologs
OrthoDB Orthologs (18) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6N051B Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search EOG69P8VP Arthropod inclusive ortholog search EOG6SJ3X1 Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6N051B)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\lbm     Drosophila simulans   Dsim\GD15337 Y   Drosophila sechellia   Dsec\GM20925 Y   Drosophila erecta   Dere\GG23252 Y   Drosophila yakuba   Dyak\GE19102 Y   Drosophila ananassae   Dana\GF12690 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA24625 Y   Drosophila persimilis   Dper\GL11147 Y   Drosophila willistoni   Dwil\GK21784 Y   Drosophila virilis   Dvir\GJ15138 Y   Drosophila mojavensis   Dmoj\GI19477 Y   Drosophila grimshawi   Dgri\GH21508 Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (EOG69P8VP)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Tribolium castaneum Red flour beetle  Tcas\TC001533   Tribolium castaneum Red flour beetle  Tcas\TC012489
Orthologs in non-Insect Arthropods (EOG6SJ3X1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Ixodes scapularis Deer tick  Isca\ISCW001003 Y Ixodes scapularis Deer tick  Isca\ISCW009188 Y Ixodes scapularis Deer tick  Isca\ISCW009186 Y Ixodes scapularis Deer tick  Isca\ISCW009187 Y
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD15337 Drosophila sechellia Dsec\GM20925 Drosophila erecta Dere\GG23252 Drosophila yakuba Dyak\GE19102 Drosophila ananassae Dana\GF12690 Drosophila pseudoobscura pseudoobscura Dpse\GA24625 Drosophila persimilis Dper\GL11147 Drosophila willistoni Dwil\GK21784 Drosophila virilis Dvir\GJ15138 Drosophila mojavensis Dmoj\GI19477 Drosophila grimshawi Dgri\GH21508
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	27278 y1 v1; P{TRiP.JF02589}attP2 34173 y1 w*; Mi{MIC}lbmMI01271 15583 y1 w67c23; P{EPgy2}lbmEY02692 35459 y1 sc* v1; P{TRiP.GL00385}attP2
Harvard	- P{XP}lbmd01697 - PBac{PB}lbmc01253 - PBac{PB}lbmc02514
VDRC	v102739 P{KK112318}VIE-260B v7936 w1118; P{GD1843}v7936 v7937 w1118; P{GD1843}v7937
Genomic Clones ( 3 )
	BACR12F04 BACR29G01 BACR36G11 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 15 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE57845
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE61670 RH44195 RH44640
Other clones	40516 83037 161412 CK01.22A.D12 CK01.98D.D11 EK154327 EK216945 EK265846 FGH116G02 FGH125B03 FGH127B04
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0016032 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35623
Antibody Information
	polyclonal (Kopczynski et al., 1996)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: lbm CG2374 (Shue, 1999.11)
Source for database merge of
Additional comments
Other Comments
	Expression is enriched in embryonic gonads. (Shigenobu et al., 2006) lbm encodes a neural tetraspanin that facilitates synapse formation. (Kopczynski et al., 1996)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078915 NM_001273828 RefSeq (Proteins) • NP_523639 NP_001260757 DDBJ / EMBL / GenBank • AAA98512 AAF59302 AAL49163 AGB93290 AY071541 BI371037 CZ468001 CZ472384 U49081 Entrez Gene - A searchable database of RefSeq genes. • 35623 UniProtKB/Swiss-Prot • Q24188
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Tetraspanin/Peripherin (IPR018499) Tetraspanin, EC2 domain (IPR008952) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE57845
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0016032 DRSC - Results from RNAi screens. • FBgn0016032 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0016032 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2374-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0016032 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35623 modMine - Data generated by the modENCODE project. • FBgn0016032
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	CG2374 (Fradkin et al., 2002, Todres et al., 2000, Keleman et al., 2009.8.5, Ni et al., 2011.7.19) Dm.Tsp42Em (Todres et al., 2000) Ibm (Franciscovich et al., 2008) lbl (Todres et al., 2000, Kopczynski, 1996.2.12, Lear et al., 1999, Kopczynski et al., 1996, ) Lbm (Kopczynski et al., 1998, Koles et al., 2012) lbm (Shigenobu et al., 2006, Perkins et al., 2009.8.10, Franciscovich et al., 2008) LBM (Brooks et al., 2011)
Name Synonym	Late Bloomer (Roush, 1996, Tran and Doe, 2008) late bloomer (Brooks et al., 2011, Edwards et al., 2009, Hong et al., 2012) latebloomer (Kamphorst et al., 2002) tetraspanin 42E (Silverman et al., 2003)
Secondary FlyBase IDs
References ( 47 )
Generate a list of	All references relating to this gene ( 47 )
List References by type	Research paper  ( 19 ) Supplementary material  ( 2 ) Review  ( 6 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 1 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 3 ) Protein sequence record  ( 1 ) Website  ( 1 )
Recent research papers ( 3 )
	Hong et al., 2012, G3 (Bethesda) 2(8): 873--882 Microarray-Based Capture of Novel Expressed Cell Type-Specific Transfrags (CoNECT) to Annotate Tissue-Specific Transcription in Drosophila melanogaster. [FBrf0219214] Koles et al., 2012, J. Biol. Chem. 287(20): 16820--16834 Mechanism of evenness interrupted (evi)-exosome release at synaptic boutons. [FBrf0218323] Brooks et al., 2011, Neuron 72(2): 316--329 A putative vesicular transporter expressed in Drosophila mushroom bodies that mediates sexual behavior may define a neurotransmitter system. [FBrf0216456] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...