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Gene Dmel\mael

General Information
Symbol	Dmel\mael	Species	D. melanogaster
Name	maelstrom	Annotation symbol	CG11254
Feature type	protein_coding_gene	FlyBase ID	FBgn0016034
Gene Model Status	Current	Stock availability	8 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	80A1-80A1	Sequence location	3L:22,717,334..22,719,334 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene maelstrom is referred to in FlyBase by the symbol Dmel\mael (CG11254, FBgn0016034). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: sequence-specific DNA binding. There is experimental evidence that it is involved in the biological process: protein localization; oocyte anterior/posterior axis specification; oocyte microtubule cytoskeleton organization; oocyte nucleus migration involved in oocyte dorsal/ventral axis specification; regulation of pole plasm oskar mRNA localization; intracellular mRNA localization; dorsal/ventral axis specification; oogenesis; negative regulation of transcription, DNA-dependent; spermatogenesis. 15 alleles are reported. The phenotypes of these alleles are annotated with: male germline cyst; ovary; germline cell; follicle cell; karyosome; spermatocyte ring canal; male germline cell; egg chamber; dorsal appendage. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: High mobility group, HMG1/HMG2. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1639178_s_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of mael. Gene sequence location is 3L:22717334..22719334.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Saito et al., 2010, Genes Dev. 24(22): 2493--2498
FB2012_01	References Anne, 2010, PLoS ONE 5(12): e14362 Sequence features BKN26194 HFA11894
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 80A1-80A1   Limits computationally determined from genome sequence between P{lacW}l(3)j1B10j1B10 and P{lacW}l(3)j2C4j2C4
Experimentally Determined Cytological Location
Cytogenetic map Notes References 79E-79E     (Clegg, 1997.9.18)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\mael for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.43
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) mael-RA FBtr0089633  NM_079493   1758   459 mael-RB FBtr0089632  NM_168958   1829   459 mael-RC FBtr0089631  NM_176388   1838   462
Additional Transcript Data & Comments
Reported size (kB)	1.8 (northern blot) (Clegg et al., 1997)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein mael-PA   FBpp0088576   51.6   459   8.30     NP_524217   AAF51851 mael-PB   FBpp0088575   51.6   459   8.30     NP_730739   AAF51852 mael-PC   FBpp0088574   52.0   462   8.30     NP_788566   AAO41286
Additional Polypeptide Data & Comments
Reported size (kDa)	459 (aa); 48 (kD observed) (Clegg et al., 1997)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • High mobility group, HMG1/HMG2 (IPR000910)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA536430   AA540519   AA820695   AA941265   AE014296 AAF51851   AE014296 AAF51852   AE014296 AAO41286   AF025953 AAB97831   AI062970   AI239186   AI512265   AI515619   AI946030   AW942554   AY119598 AAM50252   BF501780   BH256477   BI239912   BI353601   BI357258   BI357274   BI358573   BI373408   BI375520   BI482582   BI632175   BP553743   BP556952   BT125992   CO156413   CO156579   CO265380   CO274124   CO291025   CO317432   CO331197   CZ472909   CZ474001   DN154275   EC060565   EC072792   EC208019   EC215341   EC247502   EC263047   EC264862   EV598332   GH941963   GH944312   GH947529   GH957798   GH979808   GH983607
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VNS0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference adult stage | female & oogenesis   germarium & germline cell   (Clegg et al., 1997) adult stageoogenesis stage S1 -- S8   nurse cell   (Clegg et al., 1997)
Additional Descriptive Data
	During oogenesis, mael protein is detected in a punctate pattern in germ line cells throughout the germarium, including those in germarium region 1. Expression is uniform in nurse cells and oocytes in early egg chambers, but by stage S5, it is strongest around the periphery of cells. Protein accumulation decreases in stages S5 and S6, especially in the oocyte. No mael protein is detected after stage S8. (Clegg et al., 1997)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0016034    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0016034 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0016034 expression level Developmental Stage   Expression Level embryo 00-02hr    4844 embryo 02-04hr    3959 embryo 04-06hr    1389 embryo 06-08hr    1031 embryo 08-10hr    1445 embryo 10-12hr    945 embryo 12-14hr    994 embryo 14-16hr    1157 embryo 16-18hr    967 embryo 18-20hr    375 embryo 20-22hr    1821 embryo 22-24hr    1498 larva L1    81 larva L2    92 larva L3 12hr old    127 larva L3 puffstage 1-2    167 larva L3 puffstage 3-6    300 larva L3 puffstage 7-9    380 white prepupae new    365 white prepupae 12hr    487 white prepupae 24hr    623 pupae 2d postWPP    688 pupae 3d postWPP    468 pupae 4d postWPP    412 adult male 01day    611 adult male 05day    1048 adult male 30day    823 adult female 01day    1521 adult female 05day    3490 adult female 30day    3209 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4844) embryo 02-04hr  (3959) embryo 04-06hr  (1389) embryo 06-08hr  (1031) embryo 08-10hr  (1445) embryo 10-12hr  (945) embryo 12-14hr  (994) embryo 14-16hr  (1157) embryo 16-18hr  (967) embryo 18-20hr  (375) embryo 20-22hr  (1821) embryo 22-24hr  (1498) larva L1    81 larva L2    92 larva L3 12hr old  (127) larva L3 puffstage 1-2  (167) larva L3 puffstage 3-6  (300) larva L3 puffstage 7-9  (380) white prepupae new  (365) white prepupae 12hr  (487) white prepupae 24hr  (623) pupae 2d postWPP  (688) pupae 3d postWPP  (468) pupae 4d postWPP  (412) adult male 01day  (611) adult male 05day  (1048) adult male 30day  (823) adult female 01day  (1521) adult female 05day  (3490) adult female 30day  (3209) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4844) embryo 02-04hr  (3959) embryo 04-06hr    1389 embryo 06-08hr    1031 embryo 08-10hr  1445 embryo 10-12hr    945 embryo 12-14hr    994 embryo 14-16hr    1157 embryo 16-18hr    967 embryo 18-20hr    375 embryo 20-22hr  (1821) embryo 22-24hr  1498 larva L1    81 larva L2    92 larva L3 12hr old    127 larva L3 puffstage 1-2    167 larva L3 puffstage 3-6    300 larva L3 puffstage 7-9    380 white prepupae new    365 white prepupae 12hr    487 white prepupae 24hr    623 pupae 2d postWPP    688 pupae 3d postWPP    468 pupae 4d postWPP    412 adult male 01day    611 adult male 05day    1048 adult male 30day    823 adult female 01day  (1521) adult female 05day  (3490) adult female 30day  (3209) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4844 embryo 02-04hr    3959 embryo 04-06hr    1389 embryo 06-08hr    1031 embryo 08-10hr    1445 embryo 10-12hr    945 embryo 12-14hr    994 embryo 14-16hr    1157 embryo 16-18hr    967 embryo 18-20hr    375 embryo 20-22hr    1821 embryo 22-24hr    1498 larva L1    81 larva L2    92 larva L3 12hr old    127 larva L3 puffstage 1-2    167 larva L3 puffstage 3-6    300 larva L3 puffstage 7-9    380 white prepupae new    365 white prepupae 12hr    487 white prepupae 24hr    623 pupae 2d postWPP    688 pupae 3d postWPP    468 pupae 4d postWPP    412 adult male 01day    611 adult male 05day    1048 adult male 30day    823 adult female 01day    1521 adult female 05day    3490 adult female 30day    3209 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4844 embryo 02-04hr    3959 embryo 04-06hr    1389 embryo 06-08hr    1031 embryo 08-10hr    1445 embryo 10-12hr    945 embryo 12-14hr    994 embryo 14-16hr    1157 embryo 16-18hr    967 embryo 18-20hr    375 embryo 20-22hr    1821 embryo 22-24hr    1498 larva L1    81 larva L2    92 larva L3 12hr old    127 larva L3 puffstage 1-2    167 larva L3 puffstage 3-6    300 larva L3 puffstage 7-9    380 white prepupae new    365 white prepupae 12hr    487 white prepupae 24hr    623 pupae 2d postWPP    688 pupae 3d postWPP    468 pupae 4d postWPP    412 adult male 01day    611 adult male 05day    1048 adult male 30day    823 adult female 01day    1521 adult female 05day    3490 adult female 30day    3209 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0016034 expression level Developmental Stage   Expression Level embryo 00-02hr    4844 embryo 02-04hr    3959 embryo 04-06hr    1389 embryo 06-08hr    1031 embryo 08-10hr    1445 embryo 10-12hr    945 embryo 12-14hr    994 embryo 14-16hr    1157 embryo 16-18hr    967 embryo 18-20hr    375 embryo 20-22hr    1821 embryo 22-24hr    1498 larva L1    81 larva L2    92 larva L3 12hr old    127 larva L3 puffstage 1-2    167 larva L3 puffstage 3-6    300 larva L3 puffstage 7-9    380 white prepupae new    365 white prepupae 12hr    487 white prepupae 24hr    623 pupae 2d postWPP    688 pupae 3d postWPP    468 pupae 4d postWPP    412 adult male 01day    611 adult male 05day    1048 adult male 30day    823 adult female 01day    1521 adult female 05day    3490 adult female 30day    3209 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4844) embryo 02-04hr  (3959) embryo 04-06hr  (1389) embryo 06-08hr  (1031) embryo 08-10hr  (1445) embryo 10-12hr  (945) embryo 12-14hr  (994) embryo 14-16hr  (1157) embryo 16-18hr  (967) embryo 18-20hr  (375) embryo 20-22hr  (1821) embryo 22-24hr  (1498) larva L1    81 larva L2    92 larva L3 12hr old  127 larva L3 puffstage 1-2  (167) larva L3 puffstage 3-6  (300) larva L3 puffstage 7-9  (380) white prepupae new  (365) white prepupae 12hr  (487) white prepupae 24hr  (623) pupae 2d postWPP  (688) pupae 3d postWPP  (468) pupae 4d postWPP  (412) adult male 01day  (611) adult male 05day  (1048) adult male 30day  (823) adult female 01day  (1521) adult female 05day  (3490) adult female 30day  (3209) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4844) embryo 02-04hr  (3959) embryo 04-06hr    1389 embryo 06-08hr    1031 embryo 08-10hr  1445 embryo 10-12hr    945 embryo 12-14hr    994 embryo 14-16hr    1157 embryo 16-18hr    967 embryo 18-20hr    375 embryo 20-22hr  1821 embryo 22-24hr  1498 larva L1    81 larva L2    92 larva L3 12hr old    127 larva L3 puffstage 1-2    167 larva L3 puffstage 3-6    300 larva L3 puffstage 7-9    380 white prepupae new    365 white prepupae 12hr    487 white prepupae 24hr    623 pupae 2d postWPP    688 pupae 3d postWPP    468 pupae 4d postWPP    412 adult male 01day    611 adult male 05day    1048 adult male 30day    823 adult female 01day  1521 adult female 05day  (3490) adult female 30day  (3209) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4844 embryo 02-04hr    3959 embryo 04-06hr    1389 embryo 06-08hr    1031 embryo 08-10hr    1445 embryo 10-12hr    945 embryo 12-14hr    994 embryo 14-16hr    1157 embryo 16-18hr    967 embryo 18-20hr    375 embryo 20-22hr    1821 embryo 22-24hr    1498 larva L1    81 larva L2    92 larva L3 12hr old    127 larva L3 puffstage 1-2    167 larva L3 puffstage 3-6    300 larva L3 puffstage 7-9    380 white prepupae new    365 white prepupae 12hr    487 white prepupae 24hr    623 pupae 2d postWPP    688 pupae 3d postWPP    468 pupae 4d postWPP    412 adult male 01day    611 adult male 05day    1048 adult male 30day    823 adult female 01day    1521 adult female 05day    3490 adult female 30day    3209 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4844 embryo 02-04hr    3959 embryo 04-06hr    1389 embryo 06-08hr    1031 embryo 08-10hr    1445 embryo 10-12hr    945 embryo 12-14hr    994 embryo 14-16hr    1157 embryo 16-18hr    967 embryo 18-20hr    375 embryo 20-22hr    1821 embryo 22-24hr    1498 larva L1    81 larva L2    92 larva L3 12hr old    127 larva L3 puffstage 1-2    167 larva L3 puffstage 3-6    300 larva L3 puffstage 7-9    380 white prepupae new    365 white prepupae 12hr    487 white prepupae 24hr    623 pupae 2d postWPP    688 pupae 3d postWPP    468 pupae 4d postWPP    412 adult male 01day    611 adult male 05day    1048 adult male 30day    823 adult female 01day    1521 adult female 05day    3490 adult female 30day    3209 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0016034    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0016034 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0016034 expression level Tissue   Expression Level Larval Central Nervous System    11.7 Larval Midgut    2.3 Larval Hindgut    4.4 Larval Malpighian Tubules    2.1 Larval Fat Body no informative data Larval Salivary Gland    5.6 Larval Trachea    5.525 Larval Carcass    3.65 Adult Head    8.1 Adult Eye    4.725 Adult Brain    16.8 Adult Thoracic-Abdominal Ganglion    27.9 Adult Crop    3.8 Adult Midgut    3.5 Adult Hindgut    2.9 Adult Malpighian Tubules    6.1 Adult Fat Body    5.6 Adult Salivary Gland    6 Adult Heart    5.825 Adult VirginFemale Spermatheca    3.2 Adult InseminatedFemale Spermatheca    1.6 Adult Ovary    435.9 Adult Testis    258.8 Adult Male Accessory Gland    2.7 Adult Carcass    7.3 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    11.7 Larval Midgut    2.3 Larval Hindgut    4.4 Larval Malpighian Tubules    2.1 Larval Fat Body no informative data Larval Salivary Gland    5.6 Larval Trachea    5.525 Larval Carcass    3.65 Adult Head    8.1 Adult Eye    4.725 Adult Brain    16.8 Adult Thoracic-Abdominal Ganglion    27.9 Adult Crop    3.8 Adult Midgut    3.5 Adult Hindgut    2.9 Adult Malpighian Tubules    6.1 Adult Fat Body    5.6 Adult Salivary Gland    6 Adult Heart    5.825 Adult VirginFemale Spermatheca    3.2 Adult InseminatedFemale Spermatheca    1.6 Adult Ovary    435.9 Adult Testis    258.8 Adult Male Accessory Gland    2.7 Adult Carcass    7.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    11.7 Larval Midgut    2.3 Larval Hindgut    4.4 Larval Malpighian Tubules    2.1 Larval Fat Body no informative data Larval Salivary Gland    5.6 Larval Trachea    5.525 Larval Carcass    3.65 Adult Head    8.1 Adult Eye    4.725 Adult Brain    16.8 Adult Thoracic-Abdominal Ganglion    27.9 Adult Crop    3.8 Adult Midgut    3.5 Adult Hindgut    2.9 Adult Malpighian Tubules    6.1 Adult Fat Body    5.6 Adult Salivary Gland    6 Adult Heart    5.825 Adult VirginFemale Spermatheca    3.2 Adult InseminatedFemale Spermatheca    1.6 Adult Ovary    435.9 Adult Testis    258.8 Adult Male Accessory Gland    2.7 Adult Carcass    7.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    11.7 Larval Midgut    2.3 Larval Hindgut    4.4 Larval Malpighian Tubules    2.1 Larval Fat Body no informative data Larval Salivary Gland    5.6 Larval Trachea    5.525 Larval Carcass    3.65 Adult Head    8.1 Adult Eye    4.725 Adult Brain    16.8 Adult Thoracic-Abdominal Ganglion    27.9 Adult Crop    3.8 Adult Midgut    3.5 Adult Hindgut    2.9 Adult Malpighian Tubules    6.1 Adult Fat Body    5.6 Adult Salivary Gland    6 Adult Heart    5.825 Adult VirginFemale Spermatheca    3.2 Adult InseminatedFemale Spermatheca    1.6 Adult Ovary    435.9 Adult Testis    258.8 Adult Male Accessory Gland    2.7 Adult Carcass    7.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0016034 expression level Tissue   Expression Level Larval Central Nervous System    11.7 Larval Midgut    2.3 Larval Hindgut    4.4 Larval Malpighian Tubules    2.1 Larval Fat Body no informative data Larval Salivary Gland    5.6 Larval Trachea    5.525 Larval Carcass    3.65 Adult Head    8.1 Adult Eye    4.725 Adult Brain    16.8 Adult Thoracic-Abdominal Ganglion    27.9 Adult Crop    3.8 Adult Midgut    3.5 Adult Hindgut    2.9 Adult Malpighian Tubules    6.1 Adult Fat Body    5.6 Adult Salivary Gland    6 Adult Heart    5.825 Adult VirginFemale Spermatheca    3.2 Adult InseminatedFemale Spermatheca    1.6 Adult Ovary    435.9 Adult Testis    258.8 Adult Male Accessory Gland    2.7 Adult Carcass    7.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    11.7 Larval Midgut    2.3 Larval Hindgut    4.4 Larval Malpighian Tubules    2.1 Larval Fat Body no informative data Larval Salivary Gland    5.6 Larval Trachea    5.525 Larval Carcass    3.65 Adult Head    8.1 Adult Eye    4.725 Adult Brain    16.8 Adult Thoracic-Abdominal Ganglion    27.9 Adult Crop    3.8 Adult Midgut    3.5 Adult Hindgut    2.9 Adult Malpighian Tubules    6.1 Adult Fat Body    5.6 Adult Salivary Gland    6 Adult Heart    5.825 Adult VirginFemale Spermatheca    3.2 Adult InseminatedFemale Spermatheca    1.6 Adult Ovary    435.9 Adult Testis    258.8 Adult Male Accessory Gland    2.7 Adult Carcass    7.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    11.7 Larval Midgut    2.3 Larval Hindgut    4.4 Larval Malpighian Tubules    2.1 Larval Fat Body no informative data Larval Salivary Gland    5.6 Larval Trachea    5.525 Larval Carcass    3.65 Adult Head    8.1 Adult Eye    4.725 Adult Brain    16.8 Adult Thoracic-Abdominal Ganglion    27.9 Adult Crop    3.8 Adult Midgut    3.5 Adult Hindgut    2.9 Adult Malpighian Tubules    6.1 Adult Fat Body    5.6 Adult Salivary Gland    6 Adult Heart    5.825 Adult VirginFemale Spermatheca    3.2 Adult InseminatedFemale Spermatheca    1.6 Adult Ovary    435.9 Adult Testis    258.8 Adult Male Accessory Gland    2.7 Adult Carcass    7.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    11.7 Larval Midgut    2.3 Larval Hindgut    4.4 Larval Malpighian Tubules    2.1 Larval Fat Body no informative data Larval Salivary Gland    5.6 Larval Trachea    5.525 Larval Carcass    3.65 Adult Head    8.1 Adult Eye    4.725 Adult Brain    16.8 Adult Thoracic-Abdominal Ganglion    27.9 Adult Crop    3.8 Adult Midgut    3.5 Adult Hindgut    2.9 Adult Malpighian Tubules    6.1 Adult Fat Body    5.6 Adult Salivary Gland    6 Adult Heart    5.825 Adult VirginFemale Spermatheca    3.2 Adult InseminatedFemale Spermatheca    1.6 Adult Ovary    435.9 Adult Testis    258.8 Adult Male Accessory Gland    2.7 Adult Carcass    7.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    8.1   NA  Eye    4.725   NA  Brain    16.8   11.7  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    27.9   NA  Crop    3.8   2.3  Midgut    3.5   4.4  Hindgut    2.9   2.1  Malpighian Tubules    6.1   no informative data  Fat Body    5.6   5.6  Salivary Gland    6   NA  Heart    5.825   5.525  Trachea    NA   NA  VirginFemale Spermatheca    3.2   NA  InseminatedFemale Spermatheca    1.6   NA  Ovary    435.9   NA  Testis    258.8   NA  Male Accessory Gland    2.7   3.65  Carcass    7.3 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_01
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0016034 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11254-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for mael Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage | recessive maelr15 viable, with Scer\GAL4pnr-MD237 maelGD7254 Sterility Allele female sterile (with Df(3L)79E-F) maelM391 male sterile (with Df(3L)79E-F) maelM391 Other Phenotypes Allele wild-type mael+t4.5 Phenotype manifest in Allele chorion | germline clone maelr20 dorsal appendage maelr20 egg chamber maelM391 maelr15 maelr20 follicle cell maelr20 germline cell maelM391 karyosome maelM391 male germline cell (with Df(3L)79E-F) maelM391 male germline cyst (with Df(3L)79E-F) maelM391 male germline stem cell | ectopic (with Df(3L)79E-F) maelM391 microtubule & oocyte maelr15 maelr20 oocyte & centriole (with Df(3L)79E-F) maelr20 oocyte & microtubule maelunspecified oocyte & microtubule organizing center (with Df(3L)79E-F) maelr20 oocyte | germline clone maelr20 ovary maelM391 spermatocyte ring canal (with Df(3L)79E-F) maelM391
Classical Alleles ( 9 )
For All Classical Alleles Show
Allele of mael Class Mutagen Stocks Known lesion maeld02611 P-element activity 1 -- maelEY08554 P-element activity 1 -- maelKG03309a P-element activity 1 -- maelr20 Delta2-3 1 -- mael11A4 P-element activity 0 Yes maeld04567 P-element activity 0 -- maelM391 loss of function allele P-element activity 0 Yes maelr15 Delta2-3 0 -- maelunspecified 0 --
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of mael Class Mutagen Stocks Known lesion maelGD7254 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes maelGL00077 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes maelHMS00102 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes maelKK106194 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mael+t4.5 in vitro construct - genomic fragment 0 Yes maelScer\UAS.P\T.T:Zzzz\FLAG 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)79E-F (Clegg et al., 1997)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7254} NA P{KK106194} NA P{TRiP.GL00077} NA P{TRiP.HMS00102} NA P{UASp-FLAG-mael} NA characterization construct P{mael+4.5} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}maelEY08554 NA P{XP}maeld02611 NA P{XP}maeld04567 NA miscellaneous insertions P{?lacW}maelM391 NA P{SUPor-P}maelKG03309a NA insertion of enhancer trap P{lacW}mael11A4 No
Gene Ontology: Function, Process & Cellular Component ( 16 unique terms )
Terms Based on Experimental Evidence ( 14 terms )
Molecular Function
CV term Evidence References
sequence-specific DNA binding inferred from direct assay (Pek et al., 2009)
Biological Process
CV term Evidence References
dorsal/ventral axis specification inferred from mutant phenotype (Clegg et al., 1997) intracellular mRNA localization inferred from mutant phenotype (Clegg et al., 1997) negative regulation of transcription, DNA-dependent inferred from mutant phenotype (Pek et al., 2009) oocyte anterior/posterior axis specification inferred from mutant phenotype (Clegg et al., 1997) oocyte microtubule cytoskeleton organization inferred from mutant phenotype (Clegg et al., 1997) oocyte nucleus migration involved in oocyte dorsal/ventral axis specification inferred from mutant phenotype (Clegg et al., 1997) oogenesis inferred from mutant phenotype (Clegg et al., 1997) protein localization inferred from mutant phenotype (Pare and Suter, 2000) regulation of pole plasm oskar mRNA localization inferred from mutant phenotype (Cook et al., 2004) spermatogenesis inferred from mutant phenotype (Pek et al., 2009)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Findley et al., 2003) nucleus inferred from direct assay (Findley et al., 2003) P granule inferred from direct assay (Findley et al., 2003)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cytoskeleton organization traceable author statement (Johnstone and Lasko, 2001) intracellular mRNA localization traceable author statement (Johnstone and Lasko, 2001) pole plasm mRNA localization non-traceable author statement (Mahowald, 2001)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions mael allele Gene References unspecified BicD (Bryant et al., 1997) capu (Bryant et al., 1997, Clegg et al., 1997) S (Bryant et al., 1997, Clegg et al., 1997)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65723 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0016034 DroID - A comprehensive database of gene and protein interactions. • FBgn0016034 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40489
Orthologs
Genome-wide drosophilid orthologs	Dana\GF10993 Dere\GG16274 Dgri\GH14807 Dmoj\GI11511 Dsec\GM22468 Dsim\GD15049 Dvir\GJ13702 Dwil\GK16773 Dyak\mael
Curated drosophilid orthologs	Dpse\GA10868   Dyak\mael
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL001004-PA Aedes aegypti (mosquito) AGAP002022-PA Anopheles gambiae (mosquito) XP_393065.3 Apis mellifera (honey bee) 121310 Branchiostoma floridae (lancelet) ENSCINP00000020185 Ciona intestinalis (sea squirt) CPIJ001566 Culex pipens (mosquito) ENSCPOP00000004540 Cavia porcellus (guinea pig) 314556 Daphnia pulex (daphnia) ENSECAP00000012858 Equus caballus (horse) XP_001606685.1 Nasonia vitripennis (wasp) PHUM008426-PA Pediculus humanus (human body louse) XP_976484.1 Tribolium castaneum (red flour beetle) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15409 NV11245 LH14625 ISCW003201 FBgn0067951 FBgn0218773 FBgn0200923 FBgn0186721 FBgn0177338 FBgn0249827 JGI_V11_314556 JGI_V11_316385 JGI_V11_336128 FBgn0249519 FBgn0248264 FBgn0244648 FBgn0151157 FBgn0151155 FBgn0134271 FBgn0122283 FBgn0108509 FBgn0097529 FBgn0088033 CPIJ001732 CPIJ001731 CPIJ001997 CPIJ001566 BGIBMGA008424 ACYPI47501 ACYPI45298 ACYPI45240 ACYPI36542 GB17844 AGAP002022 AAEL008595 AAEL001004 PHUM304120 GLEAN_08172
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	8516 w*; maelr20/TM3, Sb1 16006 y1 w67c23; P{EPgy2}maelEY08554 35202 y1 sc* v1; P{TRiP.GL00077}attP2 34793 y1 sc* v1; P{TRiP.HMS00102}attP2 13015 y1; P{SUPor-P}KG03309b P{SUPor-P}maelKG03309a ry506/TM3, Sb1 Ser1
Harvard	- P{XP}maeld02611
VDRC	v100907 P{KK106194}VIE-260B v18198 w1118; P{GD7254}v18198
Genomic Clones ( 1 )
	BACR22O21 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 45 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT21095 LD20229
Other clones	DPiM_LD20229
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT17332 GH02363 GM05617 GM24358 LD17040 LD24545 LD25314 LD44043 LD47516 RE36534 RE43682 RE43704 RE45391 RE60680 RE63362 RE65288 SD25794
Other clones	12133 31890 78843 161586 527856 527905 bs19h03 CK01.98A.C4 Dmel_neb_008236_0883_3340 EK075842 EK113247 EK142522 EK208552 EK268021 EK298815 EN08021 EN08336 FGM226A09 FGM306E02 RP004050422 RP004208005 RP004209114 RP004242722 RP004246395 RP004260758
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0016034 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40489
Antibody Information
	polyclonal (Clegg et al., 1997, Pek et al., 2009)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: mael CG11254 (Beasley, 1999.11)
Source for database merge of
Additional comments
Other Comments
	mael is required for proper differentiation in the germline stem cell lineage in males. (Pek et al., 2009) mael is required in the germline for proper reorientation of the oocyte cytoskeleton in response to signalling from the surrounding follicular epithelium. (Bryant et al., 1997) Mutations in mael transform posterior follicle cells into anterior fates. (Clegg et al., 1997) mael acts in the germline after follicle cell determination to organise the oocyte cytoskeleton. (Clegg et al., 1997) mael function is required in the germline for correct posterior localisation of a variety of transcripts in early oocytes, including grk mRNA. Posterior localisation of grk mRNA in the early oocyte is essential for proper A/P axis formation. (Clegg et al., 1997) Mutations reveal a novel step in mRNA localisation within the oocyte. Mutants disrupt the normal assymetric distribution of markers along the A/P axis and they disrupt the microtubule-dependent migration of the oocyte nucleus. (Clegg et al., 1997) Required for the localization of morphogens and for the correct formation of the cytoskeleton in oocytes. (Ruohola-Baker et al., 1996)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079493 NM_168958 NM_176388 RefSeq (Proteins) • NP_524217 NP_730739 NP_788566 DDBJ / EMBL / GenBank • AA540519 AAB97831 AAF51851 AAF51852 AAM50252 AAO41286 AF025953 AI946030 AW942554 AY119598 BH256477 CZ472909 CZ474001 Entrez Gene - A searchable database of RefSeq genes. • 40489 UniProtKB/TrEMBL • Q9VNS0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • High mobility group, HMG1/HMG2 (IPR000910)
Linkouts
	BioGRID - A database of protein and genetic interactions • 65723 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0016034 DroID - A comprehensive database of gene and protein interactions. • FBgn0016034 DRSC - Results from RNAi screens. • FBgn0016034 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0016034 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11254-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0016034 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40489 InParanoid A subset of ortholog calls from InParanoid. • AAEL001004-PA Aedes aegypti (mosquito) AGAP002022-PA Anopheles gambiae (mosquito) XP_393065.3 Apis mellifera (honey bee) 121310 Branchiostoma floridae (lancelet) ENSCINP00000020185 Ciona intestinalis (sea squirt) CPIJ001566 Culex pipens (mosquito) ENSCPOP00000004540 Cavia porcellus (guinea pig) 314556 Daphnia pulex (daphnia) ENSECAP00000012858 Equus caballus (horse) XP_001606685.1 Nasonia vitripennis (wasp) PHUM008426-PA Pediculus humanus (human body louse) XP_976484.1 Tribolium castaneum (red flour beetle) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /torstoll/maelstr1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40489 modMine - Data generated by the modENCODE project. • FBgn0016034 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15409 NV11245 LH14625 ISCW003201 FBgn0067951 FBgn0218773 FBgn0200923 FBgn0186721 FBgn0177338 FBgn0249827 JGI_V11_314556 JGI_V11_316385 JGI_V11_336128 FBgn0249519 FBgn0248264 FBgn0244648 FBgn0151157 FBgn0151155 FBgn0134271 FBgn0122283 FBgn0108509 FBgn0097529 FBgn0088033 CPIJ001732 CPIJ001731 CPIJ001997 CPIJ001566 BGIBMGA008424 ACYPI47501 ACYPI45298 ACYPI45240 ACYPI36542 GB17844 AGAP002022 AAEL008595 AAEL001004 PHUM304120 GLEAN_08172
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	CG11254 (Keleman et al., 2009.8.5, Brandt, 2006, Ni et al., 2011.7.19) mae1 (Domazet-Loso and Tautz, 2003) mael (Anne et al., 2007, Lim and Kai, 2007, Liebl et al., 2006, Lim and Kai, 2007, Navarro et al., 2009, Pek et al., 2009, Brandt, 2006, Patil and Kai, 2010, Orsi et al., 2010, Nagao et al., 2010, Saito et al., 2010, Anne, 2010) MAEL (Janic et al., 2010)
Name Synonym	maelstrom (Clegg et al., 1997, Ruohola-Baker et al., 1996) Maelstrom (Seydoux and Braun, 2006, Pek et al., 2009, Patil and Kai, 2010, Janic et al., 2010)
Secondary FlyBase IDs
References ( 52 )
Generate a list of	All references relating to this gene ( 52 )
List References by type	Research paper  ( 19 ) Supplementary material  ( 5 ) Review  ( 9 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 4 ) Abstract  ( 6 ) FlyBase analysis  ( 1 ) Curated genome annotation  ( 1 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 )
Recent research papers ( 6 )
	Anne, 2010, PLoS ONE 5(12): e14362 Targeting and anchoring tudor in the pole plasm of the Drosophila oocyte. [FBrf0212588] Janic et al., 2010, Science 330(6012): 1824--1827 Ectopic expression of germline genes drives malignant brain tumor growth in Drosophila. [FBrf0212713] Nagao et al., 2010, RNA 16(12): 2503--2515 Biogenesis pathways of piRNAs loaded onto AGO3 in the Drosophila testis. [FBrf0212366] Orsi et al., 2010, J. Cell Sci. 123(20): 3515--3524 Drosophila I-R hybrid dysgenesis is associated with catastrophic meiosis and abnormal zygote formation. [FBrf0212012] Patil and Kai, 2010, Curr. Biol. 20(8): 724--730 Repression of Retroelements in Drosophila Germline via piRNA Pathway by the Tudor Domain Protein Tejas. [FBrf0211166] Saito et al., 2010, Genes Dev. 24(22): 2493--2498 Roles for the Yb body components Armitage and Yb in primary piRNA biogenesis in Drosophila. [FBrf0212297] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...