HMG box protein - spindle class protein - potential regulator of RNA processing or subcellular localization - essential for piRNA-mediated transcriptional transposon silencing - coordinates microtubule organization during Drosophila oogenesis through interaction with components of the microtubule-organizing center
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.43
Gene model reviewed during 5.45
Gene model reviewed during 6.02
1.8 (northern blot)
459 (aa); 48 (kD observed)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mael using the Feature Mapper tool.
During oogenesis, mael protein is detected in a punctate pattern in germ line cells throughout the germarium, including those in germarium region 1. Expression is uniform in nurse cells and oocytes in early egg chambers, but by stage S5, it is strongest around the periphery of cells. Protein accumulation decreases in stages S5 and S6, especially in the oocyte. No mael protein is detected after stage S8.
GBrowse - Visual display of RNA-Seq signalsView Dmel\mael in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: mael CG11254
mael is required for proper differentiation in the germline stem cell lineage in males.
mael is required in the germline for proper reorientation of the oocyte cytoskeleton in response to signalling from the surrounding follicular epithelium.
mael acts in the germline after follicle cell determination to organise the oocyte cytoskeleton.
mael function is required in the germline for correct posterior localisation of a variety of transcripts in early oocytes, including grk mRNA. Posterior localisation of grk mRNA in the early oocyte is essential for proper A/P axis formation.
Mutations reveal a novel step in mRNA localisation within the oocyte. Mutants disrupt the normal assymetric distribution of markers along the A/P axis and they disrupt the microtubule-dependent migration of the oocyte nucleus.
Required for the localization of morphogens and for the correct formation of the cytoskeleton in oocytes.