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Gene Dmel\Tom40

General Information
Symbol	Dmel\Tom40	Species	D. melanogaster
Name	Translocase of outer membrane 40	Annotation symbol	CG12157
Feature type	protein_coding_gene	FlyBase ID	FBgn0016041
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map	1-
Cytogenetic map	7B7-7B7	Sequence location	X:7,630,926..7,634,011 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Translocase of outer membrane 40 is referred to in FlyBase by the symbol Dmel\Tom40 (CG12157, FBgn0016041). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: P-P-bond-hydrolysis-driven protein transmembrane transporter activity. There is experimental evidence that it is involved in the biological process: cellular response to hypoxia. 3 alleles are reported. The phenotype of these alleles is annotated with: trichogen cell. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Eukaryotic porin/Tom40; Porin domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, during late pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult heart, larval trachea, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult fat body, larval/adult salivary gland, adult spermathecae, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1624205_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Tom40. Gene sequence location is X:7630926..7634011.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 7B7-7B7   Limits computationally determined from genome sequence between P{EP}CHES-1-likeEP1453 and P{EP}EP1209
Experimentally Determined Cytological Location
Cytogenetic map Notes References 7C-7C   (determined by in situ hybridisation)   (Peter et al., 2002) 7C1-7C2     (Xu, 1999.7.2) 7C-7C   (determined by in situ hybridisation)   (Schaefer et al., 1999.6.15) 7C1-7C2     (Xu and Wu, 1996)
Experimentally Determined Recombination Data
Location	1- (Xu and Wu, 1996)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Tom40 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46 Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Tom40-RA FBtr0071073  NM_143746   1684   344 Tom40-RB FBtr0071074  NM_206640   1861   344 Tom40-RC FBtr0333748  NM_001272384   2395   344
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Tom40-PA   FBpp0071031   36.3   344   7.11     NP_652003   AAF46272 Tom40-PB   FBpp0089237   36.3   344   7.11     NP_996363   AAS65272 Tom40-PC   FBpp0305890   36.3   344   7.11     NP_001259313   AGB95158
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Eukaryotic porin/Tom40 (IPR027246) Porin domain (IPR023614) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME12157
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA264816   AA439473   AA735856   AA736072   AA816335   AA816648   AA820294   AA820634   AA950542   AE014298 AAF46272   AE014298 AAS65272   AF165113 AAF20172   AE014298 AGB95158   AI108949   AI109734   AI134753   AI135101   AI258695   AI455384   AI515442   AI516358   AI516662   AI516725   AI518576   AI544218   AJ426751   AY118926 AAM50786   BG632826   BI169531   BI169998   BI171860   BI213251   BI230431   BI231551   BI231822   BI234611   BI235816   BI236043   BI239359   BI241421   BI241499   BI243229   BI356257   BI369765   BI370838   BI371308   BI371770   BI373213   BI375027   BI481858   BI486463   BI580467   BI637015   BI640825   BP555935   BP555936   BQ103140   CO187296   CO189092   CO262505   CO263718   CO267072   CO267782   CO272316   CO279870   CO281832   CO283162   CO297759   CO299592   CO300959   CO301121   CO304116   CO306344   CO307304   CO309295   CO312770   CO315385   CO316899   CO324282   CO326685   CO341819   EC057556   EC059515   EC064844   EC068591   EC069295   EC071026   EC072284   EC072915   EC086258   EC087931   EC197871   EC201336   EC204080   EC210471   EC210606   EC215290   EC220152   EC234457   EC236480   EC237821   EC238037   EC242366   EC243380   EC245672   EC247674   EC249712   EC255258   EC260125   EV579640   EV590440   EV591063   EV597038   GH956533
UniProtKB/Swiss-Prot	Q9U4L6
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   hindgut anlage   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   anterior endoderm   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) inclusive hindgut primordium   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) dorsal pharyngeal muscle primordium   (Fisher et al., 2012) hindgut proper primordium   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) somatic muscle primordium   (Fisher et al., 2012) Comment:reported as muscle system primordium visceral muscle primordium   (Fisher et al., 2012) Comment:reported as muscle system primordium trunk mesoderm   (Fisher et al., 2012) embryonic stage 13 -- 16   dorsal pharyngeal muscle   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012) embryonic large intestine   (Fisher et al., 2012) embryonic Malpighian tubule   (Fisher et al., 2012) embryonic small intestine   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval muscle system   (Fisher et al., 2012) embryonic/larval somatic muscle   (Fisher et al., 2012) embryonic/larval visceral muscle   (Fisher et al., 2012) adult stage | male   testis   (Hwa et al., 2004) Comment:apical tip northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 16   organism   (Hwa et al., 2004) adult stage | male   organism   (Hwa et al., 2004) adult stage | female   organism   (Hwa et al., 2004)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
epitope tag Stage Tissue/Position (including subcellular localization) Reference     • mitochondrion (Hwa et al., 2004) Comment:expression assayed in cultured cells mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult heart, larval trachea, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult fat body, larval/adult salivary gland, adult spermathecae, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    434.175 Larval Midgut    207.4 Larval Hindgut    367.7 Larval Malpighian Tubules    120.5 Larval Fat Body    85.2 Larval Salivary Gland    255 Larval Trachea    679.475 Larval Carcass    317.15 Adult Head    308.2 Adult Eye    354.95 Adult Brain    342.4 Adult Thoracic-Abdominal Ganglion    355.2 Adult Crop    342.7 Adult Midgut    239.3 Adult Hindgut    446.3 Adult Malpighian Tubules    275.6 Adult Fat Body    416.1 Adult Salivary Gland    170.1 Adult Heart    505.65 Adult VirginFemale Spermatheca    270.2 Adult InseminatedFemale Spermatheca    374.1 Adult Ovary    777.6 Adult Testis    87.8 Adult Male Accessory Gland    315.2 Adult Carcass    302 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    434.175 Larval Midgut    207.4 Larval Hindgut    367.7 Larval Malpighian Tubules    120.5 Larval Fat Body    85.2 Larval Salivary Gland    255 Larval Trachea  (679.475) Larval Carcass    317.15 Adult Head    308.2 Adult Eye    354.95 Adult Brain    342.4 Adult Thoracic-Abdominal Ganglion    355.2 Adult Crop    342.7 Adult Midgut    239.3 Adult Hindgut    446.3 Adult Malpighian Tubules    275.6 Adult Fat Body    416.1 Adult Salivary Gland    170.1 Adult Heart  505.65 Adult VirginFemale Spermatheca    270.2 Adult InseminatedFemale Spermatheca    374.1 Adult Ovary  (777.6) Adult Testis    87.8 Adult Male Accessory Gland    315.2 Adult Carcass    302 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    434.175 Larval Midgut    207.4 Larval Hindgut    367.7 Larval Malpighian Tubules    120.5 Larval Fat Body    85.2 Larval Salivary Gland    255 Larval Trachea    679.475 Larval Carcass    317.15 Adult Head    308.2 Adult Eye    354.95 Adult Brain    342.4 Adult Thoracic-Abdominal Ganglion    355.2 Adult Crop    342.7 Adult Midgut    239.3 Adult Hindgut    446.3 Adult Malpighian Tubules    275.6 Adult Fat Body    416.1 Adult Salivary Gland    170.1 Adult Heart    505.65 Adult VirginFemale Spermatheca    270.2 Adult InseminatedFemale Spermatheca    374.1 Adult Ovary    777.6 Adult Testis    87.8 Adult Male Accessory Gland    315.2 Adult Carcass    302 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    434.175 Larval Midgut    207.4 Larval Hindgut    367.7 Larval Malpighian Tubules    120.5 Larval Fat Body    85.2 Larval Salivary Gland    255 Larval Trachea    679.475 Larval Carcass    317.15 Adult Head    308.2 Adult Eye    354.95 Adult Brain    342.4 Adult Thoracic-Abdominal Ganglion    355.2 Adult Crop    342.7 Adult Midgut    239.3 Adult Hindgut    446.3 Adult Malpighian Tubules    275.6 Adult Fat Body    416.1 Adult Salivary Gland    170.1 Adult Heart    505.65 Adult VirginFemale Spermatheca    270.2 Adult InseminatedFemale Spermatheca    374.1 Adult Ovary    777.6 Adult Testis    87.8 Adult Male Accessory Gland    315.2 Adult Carcass    302 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    434.175 Larval Midgut    207.4 Larval Hindgut    367.7 Larval Malpighian Tubules    120.5 Larval Fat Body    85.2 Larval Salivary Gland    255 Larval Trachea    679.475 Larval Carcass    317.15 Adult Head    308.2 Adult Eye    354.95 Adult Brain    342.4 Adult Thoracic-Abdominal Ganglion    355.2 Adult Crop    342.7 Adult Midgut    239.3 Adult Hindgut    446.3 Adult Malpighian Tubules    275.6 Adult Fat Body    416.1 Adult Salivary Gland    170.1 Adult Heart    505.65 Adult VirginFemale Spermatheca    270.2 Adult InseminatedFemale Spermatheca    374.1 Adult Ovary    777.6 Adult Testis    87.8 Adult Male Accessory Gland    315.2 Adult Carcass    302 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    434.175 Larval Midgut    207.4 Larval Hindgut    367.7 Larval Malpighian Tubules    120.5 Larval Fat Body    85.2 Larval Salivary Gland    255 Larval Trachea  679.475 Larval Carcass    317.15 Adult Head    308.2 Adult Eye    354.95 Adult Brain    342.4 Adult Thoracic-Abdominal Ganglion    355.2 Adult Crop    342.7 Adult Midgut    239.3 Adult Hindgut    446.3 Adult Malpighian Tubules    275.6 Adult Fat Body    416.1 Adult Salivary Gland    170.1 Adult Heart  505.65 Adult VirginFemale Spermatheca    270.2 Adult InseminatedFemale Spermatheca    374.1 Adult Ovary  777.6 Adult Testis    87.8 Adult Male Accessory Gland    315.2 Adult Carcass    302 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    434.175 Larval Midgut    207.4 Larval Hindgut    367.7 Larval Malpighian Tubules    120.5 Larval Fat Body    85.2 Larval Salivary Gland    255 Larval Trachea    679.475 Larval Carcass    317.15 Adult Head    308.2 Adult Eye    354.95 Adult Brain    342.4 Adult Thoracic-Abdominal Ganglion    355.2 Adult Crop    342.7 Adult Midgut    239.3 Adult Hindgut    446.3 Adult Malpighian Tubules    275.6 Adult Fat Body    416.1 Adult Salivary Gland    170.1 Adult Heart    505.65 Adult VirginFemale Spermatheca    270.2 Adult InseminatedFemale Spermatheca    374.1 Adult Ovary    777.6 Adult Testis    87.8 Adult Male Accessory Gland    315.2 Adult Carcass    302 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    434.175 Larval Midgut    207.4 Larval Hindgut    367.7 Larval Malpighian Tubules    120.5 Larval Fat Body    85.2 Larval Salivary Gland    255 Larval Trachea    679.475 Larval Carcass    317.15 Adult Head    308.2 Adult Eye    354.95 Adult Brain    342.4 Adult Thoracic-Abdominal Ganglion    355.2 Adult Crop    342.7 Adult Midgut    239.3 Adult Hindgut    446.3 Adult Malpighian Tubules    275.6 Adult Fat Body    416.1 Adult Salivary Gland    170.1 Adult Heart    505.65 Adult VirginFemale Spermatheca    270.2 Adult InseminatedFemale Spermatheca    374.1 Adult Ovary    777.6 Adult Testis    87.8 Adult Male Accessory Gland    315.2 Adult Carcass    302 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    308.2   NA  Eye    354.95   NA  Brain    342.4   434.175  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    355.2   NA  Crop    342.7   207.4  Midgut    239.3   367.7  Hindgut    446.3   120.5  Malpighian Tubules    275.6   85.2  Fat Body    416.1   255  Salivary Gland    170.1   NA  Heart    505.65   679.475  Trachea    NA   NA  VirginFemale Spermatheca    270.2   NA  InseminatedFemale Spermatheca    374.1   NA  Ovary    777.6   NA  Testis    87.8   NA  Male Accessory Gland    315.2   317.15  Carcass    302 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    63 central nervous system, larvae L3    49 central nervous system, pupae P8    45 head, virgin 1-day female    28 head, virgin 4-day female    22 head, virgin 20-day female    19 head, mated 1-day female    24 head, mated 4-day female    26 head, mated 20-day female    20 head, mated 1-day male    31 head, mated 4-day male    34 head, mated 20-day male    31 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    28 digestive system, 4-day adult    41 digestive system, 20-day adult    24 fat body, larvae L3 wandering    6 fat body, white prepupae    16 fat body, pupae P8    41 carcass, larvae L3 wandering    25 carcass, 1-day adult    19 carcass, 4-day adult    34 carcass, 20-day adult    25 ovary, virgin 4-day female    198 ovary, mated 4-day female    148 testis, mated 4-day male    64 accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (63) central nervous system, larvae L3  (49) central nervous system, pupae P8  (45) head, virgin 1-day female  (28) head, virgin 4-day female    22 head, virgin 20-day female    19 head, mated 1-day female    24 head, mated 4-day female  26 head, mated 20-day female    20 head, mated 1-day male  (31) head, mated 4-day male  (34) head, mated 20-day male  (31) salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    15 digestive system, 1-day adult  (28) digestive system, 4-day adult  (41) digestive system, 20-day adult    24 fat body, larvae L3 wandering    6 fat body, white prepupae    16 fat body, pupae P8  (41) carcass, larvae L3 wandering    25 carcass, 1-day adult    19 carcass, 4-day adult  (34) carcass, 20-day adult    25 ovary, virgin 4-day female  (198) ovary, mated 4-day female  (148) testis, mated 4-day male  (64) accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    63 central nervous system, larvae L3    49 central nervous system, pupae P8    45 head, virgin 1-day female    28 head, virgin 4-day female    22 head, virgin 20-day female    19 head, mated 1-day female    24 head, mated 4-day female    26 head, mated 20-day female    20 head, mated 1-day male    31 head, mated 4-day male    34 head, mated 20-day male    31 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    28 digestive system, 4-day adult    41 digestive system, 20-day adult    24 fat body, larvae L3 wandering    6 fat body, white prepupae    16 fat body, pupae P8    41 carcass, larvae L3 wandering    25 carcass, 1-day adult    19 carcass, 4-day adult    34 carcass, 20-day adult    25 ovary, virgin 4-day female  (198) ovary, mated 4-day female  (148) testis, mated 4-day male    64 accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    63 central nervous system, larvae L3    49 central nervous system, pupae P8    45 head, virgin 1-day female    28 head, virgin 4-day female    22 head, virgin 20-day female    19 head, mated 1-day female    24 head, mated 4-day female    26 head, mated 20-day female    20 head, mated 1-day male    31 head, mated 4-day male    34 head, mated 20-day male    31 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    28 digestive system, 4-day adult    41 digestive system, 20-day adult    24 fat body, larvae L3 wandering    6 fat body, white prepupae    16 fat body, pupae P8    41 carcass, larvae L3 wandering    25 carcass, 1-day adult    19 carcass, 4-day adult    34 carcass, 20-day adult    25 ovary, virgin 4-day female    198 ovary, mated 4-day female    148 testis, mated 4-day male    64 accessory gland, mated 4-day male    16 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    63 central nervous system, larvae L3    49 central nervous system, pupae P8    45 head, virgin 1-day female    28 head, virgin 4-day female    22 head, virgin 20-day female    19 head, mated 1-day female    24 head, mated 4-day female    26 head, mated 20-day female    20 head, mated 1-day male    31 head, mated 4-day male    34 head, mated 20-day male    31 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    28 digestive system, 4-day adult    41 digestive system, 20-day adult    24 fat body, larvae L3 wandering    6 fat body, white prepupae    16 fat body, pupae P8    41 carcass, larvae L3 wandering    25 carcass, 1-day adult    19 carcass, 4-day adult    34 carcass, 20-day adult    25 ovary, virgin 4-day female    198 ovary, mated 4-day female    148 testis, mated 4-day male    64 accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (63) central nervous system, larvae L3  (49) central nervous system, pupae P8  (45) head, virgin 1-day female  28 head, virgin 4-day female    22 head, virgin 20-day female    19 head, mated 1-day female    24 head, mated 4-day female  26 head, mated 20-day female    20 head, mated 1-day male  31 head, mated 4-day male  (34) head, mated 20-day male  31 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    15 digestive system, 1-day adult  28 digestive system, 4-day adult  (41) digestive system, 20-day adult    24 fat body, larvae L3 wandering    6 fat body, white prepupae    16 fat body, pupae P8  (41) carcass, larvae L3 wandering    25 carcass, 1-day adult    19 carcass, 4-day adult  (34) carcass, 20-day adult    25 ovary, virgin 4-day female  (198) ovary, mated 4-day female  (148) testis, mated 4-day male  (64) accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    63 central nervous system, larvae L3    49 central nervous system, pupae P8    45 head, virgin 1-day female    28 head, virgin 4-day female    22 head, virgin 20-day female    19 head, mated 1-day female    24 head, mated 4-day female    26 head, mated 20-day female    20 head, mated 1-day male    31 head, mated 4-day male    34 head, mated 20-day male    31 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    28 digestive system, 4-day adult    41 digestive system, 20-day adult    24 fat body, larvae L3 wandering    6 fat body, white prepupae    16 fat body, pupae P8    41 carcass, larvae L3 wandering    25 carcass, 1-day adult    19 carcass, 4-day adult    34 carcass, 20-day adult    25 ovary, virgin 4-day female  (198) ovary, mated 4-day female  (148) testis, mated 4-day male    64 accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    63 central nervous system, larvae L3    49 central nervous system, pupae P8    45 head, virgin 1-day female    28 head, virgin 4-day female    22 head, virgin 20-day female    19 head, mated 1-day female    24 head, mated 4-day female    26 head, mated 20-day female    20 head, mated 1-day male    31 head, mated 4-day male    34 head, mated 20-day male    31 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    28 digestive system, 4-day adult    41 digestive system, 20-day adult    24 fat body, larvae L3 wandering    6 fat body, white prepupae    16 fat body, pupae P8    41 carcass, larvae L3 wandering    25 carcass, 1-day adult    19 carcass, 4-day adult    34 carcass, 20-day adult    25 ovary, virgin 4-day female    198 ovary, mated 4-day female    148 testis, mated 4-day male    64 accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, during late pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    106 embryo 02-04hr    89 embryo 04-06hr    46 embryo 06-08hr    43 embryo 08-10hr    49 embryo 10-12hr    60 embryo 12-14hr    59 embryo 14-16hr    55 embryo 16-18hr    51 embryo 18-20hr    53 embryo 20-22hr    50 embryo 22-24hr    47 larva L1    83 larva L2    84 larva L3 12hr old    49 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    18 white prepupae 12hr    18 white prepupae 24hr    21 pupae 2d postWPP    37 pupae 3d postWPP    48 pupae 4d postWPP    21 adult male 01day    26 adult male 05day    27 adult male 30day    25 adult female 01day    50 adult female 05day    78 adult female 30day    80 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (106) embryo 02-04hr  (89) embryo 04-06hr  (46) embryo 06-08hr  (43) embryo 08-10hr  (49) embryo 10-12hr  (60) embryo 12-14hr  (59) embryo 14-16hr  (55) embryo 16-18hr  (51) embryo 18-20hr  (53) embryo 20-22hr  (50) embryo 22-24hr  (47) larva L1  (83) larva L2  (84) larva L3 12hr old  (49) larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    18 white prepupae 12hr    18 white prepupae 24hr    21 pupae 2d postWPP  (37) pupae 3d postWPP  (48) pupae 4d postWPP    21 adult male 01day  26 adult male 05day  (27) adult male 30day    25 adult female 01day  (50) adult female 05day  (78) adult female 30day  (80) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  106 embryo 02-04hr    89 embryo 04-06hr    46 embryo 06-08hr    43 embryo 08-10hr    49 embryo 10-12hr    60 embryo 12-14hr    59 embryo 14-16hr    55 embryo 16-18hr    51 embryo 18-20hr    53 embryo 20-22hr    50 embryo 22-24hr    47 larva L1    83 larva L2    84 larva L3 12hr old    49 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    18 white prepupae 12hr    18 white prepupae 24hr    21 pupae 2d postWPP    37 pupae 3d postWPP    48 pupae 4d postWPP    21 adult male 01day    26 adult male 05day    27 adult male 30day    25 adult female 01day    50 adult female 05day    78 adult female 30day    80 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    106 embryo 02-04hr    89 embryo 04-06hr    46 embryo 06-08hr    43 embryo 08-10hr    49 embryo 10-12hr    60 embryo 12-14hr    59 embryo 14-16hr    55 embryo 16-18hr    51 embryo 18-20hr    53 embryo 20-22hr    50 embryo 22-24hr    47 larva L1    83 larva L2    84 larva L3 12hr old    49 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    18 white prepupae 12hr    18 white prepupae 24hr    21 pupae 2d postWPP    37 pupae 3d postWPP    48 pupae 4d postWPP    21 adult male 01day    26 adult male 05day    27 adult male 30day    25 adult female 01day    50 adult female 05day    78 adult female 30day    80 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    106 embryo 02-04hr    89 embryo 04-06hr    46 embryo 06-08hr    43 embryo 08-10hr    49 embryo 10-12hr    60 embryo 12-14hr    59 embryo 14-16hr    55 embryo 16-18hr    51 embryo 18-20hr    53 embryo 20-22hr    50 embryo 22-24hr    47 larva L1    83 larva L2    84 larva L3 12hr old    49 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    18 white prepupae 12hr    18 white prepupae 24hr    21 pupae 2d postWPP    37 pupae 3d postWPP    48 pupae 4d postWPP    21 adult male 01day    26 adult male 05day    27 adult male 30day    25 adult female 01day    50 adult female 05day    78 adult female 30day    80 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (106) embryo 02-04hr  (89) embryo 04-06hr  (46) embryo 06-08hr  (43) embryo 08-10hr  (49) embryo 10-12hr  (60) embryo 12-14hr  (59) embryo 14-16hr  (55) embryo 16-18hr  (51) embryo 18-20hr  (53) embryo 20-22hr  (50) embryo 22-24hr  (47) larva L1  (83) larva L2  (84) larva L3 12hr old  (49) larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    18 white prepupae 12hr    18 white prepupae 24hr    21 pupae 2d postWPP  (37) pupae 3d postWPP  (48) pupae 4d postWPP    21 adult male 01day  26 adult male 05day  27 adult male 30day    25 adult female 01day  (50) adult female 05day  (78) adult female 30day  (80) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  106 embryo 02-04hr    89 embryo 04-06hr    46 embryo 06-08hr    43 embryo 08-10hr    49 embryo 10-12hr    60 embryo 12-14hr    59 embryo 14-16hr    55 embryo 16-18hr    51 embryo 18-20hr    53 embryo 20-22hr    50 embryo 22-24hr    47 larva L1    83 larva L2    84 larva L3 12hr old    49 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    18 white prepupae 12hr    18 white prepupae 24hr    21 pupae 2d postWPP    37 pupae 3d postWPP    48 pupae 4d postWPP    21 adult male 01day    26 adult male 05day    27 adult male 30day    25 adult female 01day    50 adult female 05day    78 adult female 30day    80 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    106 embryo 02-04hr    89 embryo 04-06hr    46 embryo 06-08hr    43 embryo 08-10hr    49 embryo 10-12hr    60 embryo 12-14hr    59 embryo 14-16hr    55 embryo 16-18hr    51 embryo 18-20hr    53 embryo 20-22hr    50 embryo 22-24hr    47 larva L1    83 larva L2    84 larva L3 12hr old    49 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    18 white prepupae 12hr    18 white prepupae 24hr    21 pupae 2d postWPP    37 pupae 3d postWPP    48 pupae 4d postWPP    21 adult male 01day    26 adult male 05day    27 adult male 30day    25 adult female 01day    50 adult female 05day    78 adult female 30day    80 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    58 Schneider line 2 Sg4    77 embryonic 1182-4H    38 embryonic GM2    78 embryonic Kc167    45 embryonic S1    52 embryonic S3    95 leg disc CME L1    59 wing disc CME-W2    46 wing disc ML-DmD8    67 wing disc ML-DmD9    44 wing disc ML-DmD16-c3    63 wing disc ML-DmD21    95 wing disc ML-DmD32    65 haltere disc ML-DmD17-c3    75 eye-antennal disc ML-DmD11    67 antennal disc ML-DmD20-c5    44 mixed discs ML-DmD4-c1    59 CNS ML-DmBG1-c1    74 CNS ML-DmBG2-c2    54 tumorous blood cells mbn2    41 ovary fGS/OSS    33 ovary OSC    68 ovary OSS    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (58) Schneider line 2 Sg4  (77) embryonic 1182-4H  (38) embryonic GM2  (78) embryonic Kc167  (45) embryonic S1  (52) embryonic S3  (95) leg disc CME L1  (59) wing disc CME-W2  (46) wing disc ML-DmD8  (67) wing disc ML-DmD9  (44) wing disc ML-DmD16-c3  (63) wing disc ML-DmD21  (95) wing disc ML-DmD32  (65) haltere disc ML-DmD17-c3  (75) eye-antennal disc ML-DmD11  (67) antennal disc ML-DmD20-c5  (44) mixed discs ML-DmD4-c1  (59) CNS ML-DmBG1-c1  (74) CNS ML-DmBG2-c2  (54) tumorous blood cells mbn2  (41) ovary fGS/OSS  (33) ovary OSC  (68) ovary OSS  (29) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    58 Schneider line 2 Sg4    77 embryonic 1182-4H    38 embryonic GM2    78 embryonic Kc167    45 embryonic S1    52 embryonic S3    95 leg disc CME L1    59 wing disc CME-W2    46 wing disc ML-DmD8    67 wing disc ML-DmD9    44 wing disc ML-DmD16-c3    63 wing disc ML-DmD21    95 wing disc ML-DmD32    65 haltere disc ML-DmD17-c3    75 eye-antennal disc ML-DmD11    67 antennal disc ML-DmD20-c5    44 mixed discs ML-DmD4-c1    59 CNS ML-DmBG1-c1    74 CNS ML-DmBG2-c2    54 tumorous blood cells mbn2    41 ovary fGS/OSS    33 ovary OSC    68 ovary OSS    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    58 Schneider line 2 Sg4    77 embryonic 1182-4H    38 embryonic GM2    78 embryonic Kc167    45 embryonic S1    52 embryonic S3    95 leg disc CME L1    59 wing disc CME-W2    46 wing disc ML-DmD8    67 wing disc ML-DmD9    44 wing disc ML-DmD16-c3    63 wing disc ML-DmD21    95 wing disc ML-DmD32    65 haltere disc ML-DmD17-c3    75 eye-antennal disc ML-DmD11    67 antennal disc ML-DmD20-c5    44 mixed discs ML-DmD4-c1    59 CNS ML-DmBG1-c1    74 CNS ML-DmBG2-c2    54 tumorous blood cells mbn2    41 ovary fGS/OSS    33 ovary OSC    68 ovary OSS    29 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    58 Schneider line 2 Sg4    77 embryonic 1182-4H    38 embryonic GM2    78 embryonic Kc167    45 embryonic S1    52 embryonic S3    95 leg disc CME L1    59 wing disc CME-W2    46 wing disc ML-DmD8    67 wing disc ML-DmD9    44 wing disc ML-DmD16-c3    63 wing disc ML-DmD21    95 wing disc ML-DmD32    65 haltere disc ML-DmD17-c3    75 eye-antennal disc ML-DmD11    67 antennal disc ML-DmD20-c5    44 mixed discs ML-DmD4-c1    59 CNS ML-DmBG1-c1    74 CNS ML-DmBG2-c2    54 tumorous blood cells mbn2    41 ovary fGS/OSS    33 ovary OSC    68 ovary OSS    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (58) Schneider line 2 Sg4  (77) embryonic 1182-4H  (38) embryonic GM2  (78) embryonic Kc167  (45) embryonic S1  (52) embryonic S3  (95) leg disc CME L1  (59) wing disc CME-W2  (46) wing disc ML-DmD8  (67) wing disc ML-DmD9  (44) wing disc ML-DmD16-c3  (63) wing disc ML-DmD21  (95) wing disc ML-DmD32  (65) haltere disc ML-DmD17-c3  (75) eye-antennal disc ML-DmD11  (67) antennal disc ML-DmD20-c5  (44) mixed discs ML-DmD4-c1  (59) CNS ML-DmBG1-c1  (74) CNS ML-DmBG2-c2  (54) tumorous blood cells mbn2  (41) ovary fGS/OSS  (33) ovary OSC  (68) ovary OSS  29 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    58 Schneider line 2 Sg4    77 embryonic 1182-4H    38 embryonic GM2    78 embryonic Kc167    45 embryonic S1    52 embryonic S3    95 leg disc CME L1    59 wing disc CME-W2    46 wing disc ML-DmD8    67 wing disc ML-DmD9    44 wing disc ML-DmD16-c3    63 wing disc ML-DmD21    95 wing disc ML-DmD32    65 haltere disc ML-DmD17-c3    75 eye-antennal disc ML-DmD11    67 antennal disc ML-DmD20-c5    44 mixed discs ML-DmD4-c1    59 CNS ML-DmBG1-c1    74 CNS ML-DmBG2-c2    54 tumorous blood cells mbn2    41 ovary fGS/OSS    33 ovary OSC    68 ovary OSS    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    58 Schneider line 2 Sg4    77 embryonic 1182-4H    38 embryonic GM2    78 embryonic Kc167    45 embryonic S1    52 embryonic S3    95 leg disc CME L1    59 wing disc CME-W2    46 wing disc ML-DmD8    67 wing disc ML-DmD9    44 wing disc ML-DmD16-c3    63 wing disc ML-DmD21    95 wing disc ML-DmD32    65 haltere disc ML-DmD17-c3    75 eye-antennal disc ML-DmD11    67 antennal disc ML-DmD20-c5    44 mixed discs ML-DmD4-c1    59 CNS ML-DmBG1-c1    74 CNS ML-DmBG2-c2    54 tumorous blood cells mbn2    41 ovary fGS/OSS    33 ovary OSC    68 ovary OSS    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    21 heat shock, 4-day adult    42 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    18 Cadmium 50 mM 48 hrs, 4-day adult    49 Cadmium 100 mM 48 hrs, 4-day adult    95 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    151 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    51 Ethanol 2.5% 3 hrs, larvae L3    73 Ethanol 5% 3 hrs, larvae L3    27 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    99 Caffeine 25 mg/ml 48 hrs, 4-day adult    39 Paraquat 5 mM 48 hrs, 4-day adult    78 Paraquat 10 mM 48 hrs, 4-day adult    51 Rotenone 2 μg 12 hrs, larvae L3    30 Rotenone 8 μg 12 hrs, larvae L3    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    21 heat shock, 4-day adult  (42) Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    18 Cadmium 50 mM 48 hrs, 4-day adult  (49) Cadmium 100 mM 48 hrs, 4-day adult  (95) Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult  (151) Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult  (51) Ethanol 2.5% 3 hrs, larvae L3  (73) Ethanol 5% 3 hrs, larvae L3  (27) Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (99) Caffeine 25 mg/ml 48 hrs, 4-day adult  (39) Paraquat 5 mM 48 hrs, 4-day adult  (78) Paraquat 10 mM 48 hrs, 4-day adult  (51) Rotenone 2 μg 12 hrs, larvae L3  (30) Rotenone 8 μg 12 hrs, larvae L3  (36) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    21 heat shock, 4-day adult    42 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    18 Cadmium 50 mM 48 hrs, 4-day adult    49 Cadmium 100 mM 48 hrs, 4-day adult    95 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult  (151) Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    51 Ethanol 2.5% 3 hrs, larvae L3    73 Ethanol 5% 3 hrs, larvae L3    27 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    99 Caffeine 25 mg/ml 48 hrs, 4-day adult    39 Paraquat 5 mM 48 hrs, 4-day adult    78 Paraquat 10 mM 48 hrs, 4-day adult    51 Rotenone 2 μg 12 hrs, larvae L3    30 Rotenone 8 μg 12 hrs, larvae L3    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    21 heat shock, 4-day adult    42 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    18 Cadmium 50 mM 48 hrs, 4-day adult    49 Cadmium 100 mM 48 hrs, 4-day adult    95 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    151 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    51 Ethanol 2.5% 3 hrs, larvae L3    73 Ethanol 5% 3 hrs, larvae L3    27 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    99 Caffeine 25 mg/ml 48 hrs, 4-day adult    39 Paraquat 5 mM 48 hrs, 4-day adult    78 Paraquat 10 mM 48 hrs, 4-day adult    51 Rotenone 2 μg 12 hrs, larvae L3    30 Rotenone 8 μg 12 hrs, larvae L3    36 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    21 heat shock, 4-day adult    42 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    18 Cadmium 50 mM 48 hrs, 4-day adult    49 Cadmium 100 mM 48 hrs, 4-day adult    95 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    151 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    51 Ethanol 2.5% 3 hrs, larvae L3    73 Ethanol 5% 3 hrs, larvae L3    27 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    99 Caffeine 25 mg/ml 48 hrs, 4-day adult    39 Paraquat 5 mM 48 hrs, 4-day adult    78 Paraquat 10 mM 48 hrs, 4-day adult    51 Rotenone 2 μg 12 hrs, larvae L3    30 Rotenone 8 μg 12 hrs, larvae L3    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    21 heat shock, 4-day adult  (42) Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    18 Cadmium 50 mM 48 hrs, 4-day adult  (49) Cadmium 100 mM 48 hrs, 4-day adult  (95) Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult  (151) Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult  (51) Ethanol 2.5% 3 hrs, larvae L3  (73) Ethanol 5% 3 hrs, larvae L3  27 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (99) Caffeine 25 mg/ml 48 hrs, 4-day adult  (39) Paraquat 5 mM 48 hrs, 4-day adult  (78) Paraquat 10 mM 48 hrs, 4-day adult  (51) Rotenone 2 μg 12 hrs, larvae L3  30 Rotenone 8 μg 12 hrs, larvae L3  (36) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    21 heat shock, 4-day adult    42 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    18 Cadmium 50 mM 48 hrs, 4-day adult    49 Cadmium 100 mM 48 hrs, 4-day adult    95 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult  (151) Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    51 Ethanol 2.5% 3 hrs, larvae L3    73 Ethanol 5% 3 hrs, larvae L3    27 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    99 Caffeine 25 mg/ml 48 hrs, 4-day adult    39 Paraquat 5 mM 48 hrs, 4-day adult    78 Paraquat 10 mM 48 hrs, 4-day adult    51 Rotenone 2 μg 12 hrs, larvae L3    30 Rotenone 8 μg 12 hrs, larvae L3    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    21 heat shock, 4-day adult    42 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    18 Cadmium 50 mM 48 hrs, 4-day adult    49 Cadmium 100 mM 48 hrs, 4-day adult    95 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    151 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    51 Ethanol 2.5% 3 hrs, larvae L3    73 Ethanol 5% 3 hrs, larvae L3    27 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    99 Caffeine 25 mg/ml 48 hrs, 4-day adult    39 Paraquat 5 mM 48 hrs, 4-day adult    78 Paraquat 10 mM 48 hrs, 4-day adult    51 Rotenone 2 μg 12 hrs, larvae L3    30 Rotenone 8 μg 12 hrs, larvae L3    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_19 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • LD23842 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0016041 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12157-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Tom40 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | larval stage Tom40G0216 lethal | recessive Tom40G0216 partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 Tom40GD5210 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 Tom40GD5210 Phenotype manifest in Allele trichogen cell, with Scer\GAL4pnr-MD237 Tom40GD5210
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Tom40 Class Mutagen Stocks Known lesion Tom40G0216 P-element activity 2 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Tom40 Class Mutagen Stocks Known lesion Tom40GD5210 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Tom40JF02030 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Duplicated in	Dp(1;3)DC180 (Popodi et al., 2010-, Venken et al., 2010)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD5210} NA P{TRiP.JF02030} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}Tom40G0216 No
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cellular response to hypoxia inferred from mutant phenotype (Lee et al., 2008)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
P-P-bond-hydrolysis-driven protein transmembrane transporter activity inferred from sequence or structural similarity with UniProtKB:O96008 (Sardiello et al., 2003.6.11)
Biological Process
CV term Evidence References
protein targeting to mitochondrion inferred from sequence or structural similarity with UniProtKB:O96008 (Sardiello et al., 2003.6.11) transmembrane transport inferred from electronic annotation with InterPro:IPR001925 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
mitochondrial outer membrane translocase complex inferred from sequence or structural similarity with EMBL:AF043250 (FlyBase, 1992-) inferred from sequence or structural similarity with UniProtKB:O96008 (Sardiello et al., 2003.6.11)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Tom40 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 69425 DroID - A comprehensive database of gene and protein interactions. • FBgn0016041 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44978
Orthologs
OrthoDB Orthologs (52) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG60S11S Dipteran inclusive ortholog search EOG6WM53J Insect inclusive ortholog search EOG6XD2N0 Arthropod inclusive ortholog search EOG6D51DK Metazoa inclusive ortholog search EOG6WQCWM
Orthologs in Drosophila Species (EOG60S11S)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Tom40     Drosophila simulans   Dsim\GD16856 Y   Drosophila sechellia   Dsec\GM17536 Y   Drosophila erecta   Dere\GG19657 Y   Drosophila yakuba   Dyak\GE15731 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA11443 Y   Drosophila persimilis   Dper\GL14724 Y   Drosophila willistoni   Dwil\GK25006     Drosophila virilis   Dvir\GJ15896 Y   Drosophila mojavensis   Dmoj\GI16206 Y   Drosophila grimshawi   Dgri\GH12583 Y
Orthologs in non-Drosophila Dipterans (EOG6WM53J)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL007001 Y Anopheles gambiae Malaria mosquito  Agam\AGAP007871 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ002542 Y
Orthologs in non-Dipteran Insects (EOG6XD2N0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC408284 Y Apis mellifera Western honey bee  Amel\GB44171 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG002150 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007451 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH17362 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH18251 Y Atta cephalotes Leafcutter ant  Acep\ACEP19483 Y Atta cephalotes Leafcutter ant  Acep\ACEP15041 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO17078 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO16560 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL18325 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL21801 Y Linepithema humile Argentine ant  Lhum\LH17125 Y Linepithema humile Argentine ant  Lhum\LH16643 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB11184 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB15754 Y Solenopsis invicta Red fire ant  Sinv\SINV14701 Y Solenopsis invicta Red fire ant  Sinv\SINV25342 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI001526 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI005876 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI010046 Y Bombyx mori Silkmoth  Bmor\BGIBMGA013348 Y Pediculus humanus Human body louse  Phum\PHUM366110 Y Tribolium castaneum Red flour beetle  Tcas\TC003426 Y
Orthologs in non-Insect Arthropods (EOG6D51DK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\ndhD Y
Orthologs in non-Arthropod Metazoa (EOG6WQCWM)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\C18E9.6 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_025777gn Y Danio rerio Zebrafish  Drer\tomm40 Y Danio rerio Zebrafish  Drer\tomm40l Y Xenopus tropicalis Western clawed frog  Xtro\tomm40l Y Xenopus tropicalis Western clawed frog  Xtro\tomm40 Y Gallus gallus Domestic chicken  Ggal\ENSGALG00000013827 Y Mus musculus House mouse  Mmus\Tomm40l Y Mus musculus House mouse  Mmus\Tomm40 Y Rattus norvegicus Norway rat  Rnor\Tomm40l Y Rattus norvegicus Norway rat  Rnor\Tomm40 Y Homo sapiens Human  Hsap\TOMM40 Y Homo sapiens Human  Hsap\TOMM40L Y
Human Orthologs (2)
Gene OMIM HGNC Hsap\TOMM40     Hsap\TOMM40L
AAA Orthologs (9) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD16856 Drosophila sechellia Dsec\GM17536 Drosophila erecta Dere\GG19657 Drosophila yakuba Dyak\GE15731 Drosophila pseudoobscura pseudoobscura Dpse\GA11443 Drosophila persimilis Dper\GL14724 Drosophila virilis Dvir\GJ15896 Drosophila mojavensis Dmoj\GI16206 Drosophila grimshawi Dgri\GH12583
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	26005 y1 v1; P{TRiP.JF02030}attP2 11859 w67c23 P{lacW}Tom40G0216/FM7c
Kyoto	111810 y1 w* P{lacW}Tom40G0216 P{neoFRT}19A/FM7c; P{ey-FLP.N}5
VDRC	v13177 w1118; P{GD5210}v13177 v13178 w1118; P{GD5210}v13178/TM3
Genomic Clones ( 1 )
	BACR26L11 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 106 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD23842
Other clones	DPiM_LD23842
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH07434 GH09008 GH12294 GH12734 GH14604 GM09976 GM10937 LD01234 LD03067 LD08528 LD14055 LD24459 LD30381 LD38159 LD42209 LD42613 LD42727 LD47279 LD47675 LP01947 RE10737 RE11332 RE13738 RE14112 RE18616 RE22430 RE24356 RE30340 RE31752 RE32032 RE35831 RE38480 RE38580 RE40806 RE42349 RE56053 RE57603 RE58174 RE58746 RE60452 RE62736 RE64465 RE69890 RE74663 SD18895 SD23831
Other clones	8185 28568 33815 36851 38726 51464 54828 65860 74679 81483 97114 101980 104987 144398 148528 158579 160765 162529 214249.13 214381.5 CK01.8C.G5 CK01.32C.A10 CK01.51D.B6 CK01.101C.F3 CK01.107A.H8 CK01.128C.E6 CK01.145B.C12 Dmel_dig_000563_0719_0396 Dmel_neb_012000_0846_3555 Dmel_neb_013848_0405_2327 Dmel_neb_014247_0402_2567 EK027835 EK043006 EK085617 EK089364 EK106722 EK136236 EK148630 EK151829 EK158909 EK162410 EK170502 EK175908 EK179759 EK180201 EK193124 EK217302 EK229944 EK243755 EK250829 EK254323 EK261259 EK266120 EP04439 EP13226 FGM238A03 RP004076286 UUGC0538
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0016041 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44978
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Tom40 ms(1)15 (Swiss-Prot Project Members, 2000.10.1)
Source for database merge of	Source for merge of: ms(1)15 CG12157 (Bayraktaroglu, 2000.8.7) Source for merge of: Tom40 l(1)G0216 (Peter et al., 2002)
Additional comments	The tomboy40 gene may have been derived from the Tom40 gene by retroposition. (Dai et al., 2006)
Other Comments
	Tom40 P-element induced male sterile mutation demonstrates Tom40 is involved in early stem cell division. (Xu and Wu, 1996)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_143746 NM_206640 NM_001272384 RefSeq (Proteins) • NP_652003 NP_996363 NP_001259313 DDBJ / EMBL / GenBank • AA820294 AAF20172 AAF46272 AAM50786 AAS65272 AF165113 AGB95158 AI455384 AJ426751 AY118926 Entrez Gene - A searchable database of RefSeq genes. • 44978 UniProtKB/Swiss-Prot • Q9U4L6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Eukaryotic porin/Tom40 (IPR027246) Porin domain (IPR023614) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME12157 BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD23842
Linkouts
	BioGRID - A database of protein and genetic interactions • 69425 DroID - A comprehensive database of gene and protein interactions. • FBgn0016041 DRSC - Results from RNAi screens. • FBgn0016041 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0016041 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12157-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0016041 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44978 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44978 modMine - Data generated by the modENCODE project. • FBgn0016041
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	CG12157 (Hwa et al., 2004, Labourier et al., 2002, Dai et al., 2006, Perkins et al., 1.15.2009, Lee et al., 2008, Ida et al., 2009, Cammarato et al., 2011, Derré et al., 2007, Tsubouchi et al., 2012) dtom40 (Hwa et al., 2004) l(1)G0216 (Schaefer et al., 1999.6.15, ) mit (Xu, 1999.7.2) ms15 (Xu and Wu, 1996) ms(1)15   Tom40 (Tan et al., 2009, Lee et al., 2008, Ida et al., 2009, Popodi et al., 2010-, Engström et al., 2007, Derré et al., 2007, Tsubouchi et al., 2012, Venken et al., 2010) tom40 (Bai et al., 2007, Smibert et al., 2012)
Name Synonym	membrane import protein (Xu, 1999.7.2) Translocase of outer membrane 40 (Hwa et al., 2004, Cammarato et al., 2011, Tsubouchi et al., 2012)
Secondary FlyBase IDs
	FBgn0027267 FBgn0029960
References ( 37 )
Generate a list of	All references relating to this gene ( 37 )
List References by type	Research paper  ( 12 ) Supplementary material  ( 8 ) Review  ( 1 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 1 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Protein sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 1 )
	Díaz-Castillo and Ranz, 2012, Mol. Biol. Evol. 29(9): 2105--2108 Nuclear chromosome dynamics in the Drosophila male germ line contribute to the nonrandom genomic distribution of retrogenes. [FBrf0219274] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...