38D.25, 6-4 photolyase
Gene model reviewed during 5.48
2.0 (northern blot)
540 (aa); 62.9 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\phr6-4 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\phr6-4 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: phr6-4 CG2488
Gene is involved in pre-replication DNA photorepair.
The action mechanism of phr6-4 with regard to binding specificity and catalytic mechanism by using conventional substrates, substrate analogs and presumed transition state analogs. The protein binds to its substrate and repairs it by a mechanism quite similar to the recognition and repair of Pyr<>Pyr by its cognate photolyase.
Drosophila have two types of photolyase, the substrate of each photolyase is completely different. Photolyase repairs UV induced DNA damage, the two types of DNA damage are cyclobutane pyrimidine dimer (CPD) and (6-4) photoproduct. phr6-4 encodes the photolyase that specifically repairs (6-4) photoproduct.
An enzyme that catalyses the light-dependent repair of (6-4) photoproduct exists in D.melanogaster.
Encodes a photolyase that repairs (6-4) photoproduct induced by UV radiation of DNA.