FlyBase Gene Report: Dmel\Sema1b

General Information

Symbol

Dmel\Sema1b

Species

D. melanogaster

Name

Semaphorin 1b

Annotation Symbol

CG6446

Feature Type

protein_coding_gene

FlyBase ID

FBgn0016059

Gene Model Status

Current

Stock Availability

9 publicly available

Gene Snapshot

Contributions welcome

Other Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Sema-1b, sema-III, Sema 1b, semaphorin-like, semaphorin

Key Links

Genomic Location

Cytogenetic map

54D4-54D5

Sequence location

2R:17,672,839..17,683,499 [-]

Recombination map

2-83

RefSeq locus

NT_033778 REGION:17672839..17683499

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables chemorepellent activity

inferred from biological aspect of ancestor with PANTHER:PTN000867340

(assigned by GO_Central )

(Gaudet et al., 2011)

enables semaphorin receptor binding

inferred from biological aspect of ancestor with PANTHER:PTN000112368

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (6 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in embryonic development via the syncytial blastoderm

inferred from expression pattern

(Khare et al., 2000)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

involved_in axon guidance

inferred from biological aspect of ancestor with PANTHER:PTN000112368

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in negative chemotaxis

inferred from biological aspect of ancestor with PANTHER:PTN000744245

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in negative regulation of axon extension involved in axon guidance

inferred from biological aspect of ancestor with PANTHER:PTN000867340

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in positive regulation of cell migration

inferred from biological aspect of ancestor with PANTHER:PTN000867340

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in semaphorin-plexin signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN000112368

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in cytosol

inferred from high throughput direct assay

(Lye et al., 2014)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in extracellular space

inferred from biological aspect of ancestor with PANTHER:PTN000744245

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

SEMAPHORINS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

SEMAPHORINS -: The Semaphorins are a family of membrane and secreted short-range signaling proteins, originally characterized for their role in axon guidance. The major signal transducing receptors for the semaphorins are the plexins. (Adapted from FBrf0233112, FBrf0137217 and PMID:23253452).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Sema1b for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.50

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Sema1b-RA

FBtr0086890

NM_137400

4269

770

Sema1b-RB

FBtr0086891

NM_206157

4262

770

Sema1b-RC

FBtr0302161

NM_001169707

3910

770

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Sema1b-PA

FBpp0086050

85.2

770

6.96

NP_611244

AAF57816

Sema1b-PB

FBpp0089289

85.2

770

6.96

NP_995879

AAS64817

Sema1b-PC

FBpp0291371

85.2

770

6.96

NP_001163178

ACZ94450

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

770 aa isoforms: Sema1b-PA, Sema1b-PB, Sema1b-PC

Additional Polypeptide Data and Comments

Reported size (kDa)

759 (aa); 84 (kD predicted)

(Khare et al., 2000)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Sema1b using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 5 -- 7

ventral ectoderm

Comment: bilateral stripes, 1-2 cells wide

(Khare et al., 2000)

embryonic stage 8 -- 10

ventral midline of embryo

(Khare et al., 2000)

embryonic stage 5 -- 6

mesectoderm

(Kearney et al., 2004)

embryonic stage 7 -- 8

mesectoderm anlage

(Kearney et al., 2004)

embryonic stage 9 -- 12

midline primordium

(Kearney et al., 2004)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 12 -- 15

ectoderm

(Khare et al., 2000)

embryonic stage & pupal stage

(Khare et al., 2000)

adult stage & oogenesis stage S10

nurse cell

(Khare et al., 2000)

embryonic stage 2

organism | ubiquitous

(Khare et al., 2000)

adult stage oogenesis stage S2 -- S8

ovariole

(Khare et al., 2000)

embryonic stage 5 -- 10

mesectoderm

(Khare et al., 2000)

Additional Descriptive Data

Sema1b transcripts are first expressed in early stages of oogenesis where staining is observed in ovarioles and nurse cells. In early embryos, staining is uniform. At stage 5, Sema1b transcripts are observed in two lateral stripes of 1-2 cells wide. These stripes meet at the ventral surface at stage 8 as a result of ventral furrow formation and may be mesectodermal cells. In later embryonic stages, staining is primarily in the ectoderm.

(Khare et al., 2000)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytosol

inferred from high throughput direct assay

(Lye et al., 2014)

Expression Deduced from Reporters

Reporter: P{GawB}Sema1b^NP1166

Stage

Tissue/Position (including subcellular localization)

Reference

oogenesis

polar follicle cell

(Wittes and Schüpbach, 2019)

follicle cell

Comment: posterior follicle cell

(Wittes and Schüpbach, 2019)

Reporter: PBac{806.LOX-SVS-2}Sema1b^CPTI003971

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

lamina

(Knowles-Barley, 2011.8.24)

adult brain cell body rind

(Knowles-Barley, 2011.8.24)

oogenesis

polar follicle cell

(Wittes and Schüpbach, 2019)

follicle cell

Comment: posterior follicle cell

(Wittes and Schüpbach, 2019)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Sema1b in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Sema1b

View exonic expression by tissue for Dmel\Sema1b

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0016059

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG6446-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6446

Flygut - An atlas of the Drosophila adult midgut

FBgn0016059

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 8 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Sema1b

Transgenic constructs containing regulatory region of Sema1b

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation

Gene disrupted in

Df(2R)Exel7149

(Ryder, 2004.4.26)

Inferred from location

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Other Phenotypes

Allele

abnormal locomotor behavior | adult stage, with Scer\GAL4^VGlut-OK371

Sema1b^KK104666

abnormal neuroanatomy, with Scer\GAL4^F63

Sema1b^UAS.cWa

abnormal neuroanatomy, with Scer\GAL4^l(3)H94-H94

Sema1b^UAS.cWa

Phenotype manifest in

Allele

filamentous actin

Sema1b^unspecified

intersegmental nerve, with Scer\GAL4^F63

Sema1b^UAS.cWa

intersegmental nerve, with Scer\GAL4^l(3)H94-H94

Sema1b^UAS.cWa

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (20)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\SEMA6A

7 of 15

Yes

Hsap\SEMA6B

7 of 15

Yes

Hsap\SEMA6D

7 of 15

Yes

Hsap\SEMA6C

6 of 15

Yes

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (21)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Sema6a

7 of 15

Yes

Mmus\Sema6b

7 of 15

Yes

Mmus\Sema6d

7 of 15

Yes

Mmus\Sema6c

6 of 15

Yes

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (20)

Rnor\Sema6a

7 of 13

Yes

Rnor\Sema6c

6 of 13

Yes

Rnor\Sema6b

5 of 13

Yes

4 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

Xenopus tropicalis (Western clawed frog) (15)

Xtro\sema6d

5 of 12

Yes

Xtro\sema6a

4 of 12

Xtro\sema6b

4 of 12

Yes

4 of 12

3 of 12

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

Danio rerio (Zebrafish) (37)

Drer\sema6dl

8 of 15

Yes

Drer\sema6d

7 of 15

Yes

Drer\sema6e

7 of 15

Yes

Drer\sema6bb

6 of 15

Yes

Drer\sema6a

5 of 15

Yes

Drer\sema6ba

5 of 15

Yes

4 of 15

4 of 15

4 of 15

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

Drer\si:ch211-129c21.1

3 of 15

3 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

Drer\si:ch211-113g11.6

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (4)

Cele\smp-1

8 of 15

Yes

Cele\mab-20

2 of 15

Cele\smp-2

2 of 15

Yes

Cele\F23H12.5

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091902SQ )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA19600

Drosophila persimilis

Dper\GL17680

Drosophila willistoni

Dwil\GK15918

Drosophila virilis

Dvir\GJ21763

Drosophila mojavensis

Dmoj\GI18743

Drosophila grimshawi

Dgri\GH21142

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091502J9 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17018424

Glossina morsitans

Tsetse fly

Gmor\GMOY003361

Mayetiola destructor

Hessian fly

Mdes\Mdes009816

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL003063

Anopheles darlingi

American malaria mosquito

Adar\ADAC008907

Anopheles gambiae

Malaria mosquito

Agam\AGAP005742

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ000027

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W02B9 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA003697

Danaus plexippus

Monarch butterfly

Dple\DPOGS203791-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL012513

Apis florea

Little honeybee

Aflo\2147485265

Apis mellifera

Western honey bee

Amel\GB43476

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP20312

Bombus terrestris

Buff-tailed bumblebee

Bter\15214684

Linepithema humile

Argentine ant

Lhum\LH16031

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:000c4c

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG005201

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG005204

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG005203

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_02477

Tribolium castaneum

Red flour beetle

Tcas\TC014179

Pediculus humanus

Human body louse

Phum\PHUM062540

Rhodnius prolixus

Kissing bug

Rpro\RPRC010471

Cimex lectularius

Bed bug

Clec\CLEC006275

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI001786

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_15414

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X03JM )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR012665

Strigamia maritima

European centipede

Smar\SMAR012278

Strigamia maritima

European centipede

Smar\SMAR004798

Ixodes scapularis

Black-legged tick

Isca\ISCW011583

Stegodyphus mimosarum

African social velvet spider

Smim\KFM69352.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM69353.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM72255.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur18g00820

Tetranychus urticae

Two-spotted spider mite

Turt\tetur18g00830

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_221078

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_328717

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0QST )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Ciona intestinalis

Vase tunicate

Cint\LOC100178887

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (4)

Gene Symbol

Score

Source

Alignment

4 of 10

2 of 10

2 of 10

2 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

Sema1b^KK104666

exacerbates atypical teratoid rhabdoid tumor

modeled by Snr1^KK101602

(Tegeder et al., 2019)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SEMA6A; semaphorin 6A

7 of 15

605885

SEMA6B; semaphorin 6B

7 of 15

608873

EPILEPSY, PROGRESSIVE MYOCLONIC, 11; EPM11

SEMA6D; semaphorin 6D

7 of 15

609295

SEMA6C; semaphorin 6C

6 of 15

609294

SEMA3A; semaphorin 3A

3 of 15

603961

HYPOGONADOTROPIC HYPOGONADISM 16 WITH OR WITHOUT ANOSMIA; HH16

hypogonadotropic hypogonadism 16 with or without anosmia

SEMA3B; semaphorin 3B

3 of 15

601281

SEMA3C; semaphorin 3C

3 of 15

602645

SEMA3D; semaphorin 3D

3 of 15

609907

SEMA3E; semaphorin 3E

3 of 15

608166

CHARGE SYNDROME

CHARGE syndrome

SEMA3F; semaphorin 3F

3 of 15

601124

SEMA3G; semaphorin 3G

3 of 15

SEMA4D; semaphorin 4D

3 of 15

601866

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Sema1b - PlexA

enzyme linked immunosorbent assay, x-ray crystallography, molecular sieving, light scattering, fluorescent resonance energy transfer, fluorescence microscopy, microscale thermophoresis, predetermined participant

(Rozbesky et al., 2020, Rozbesky et al., 2019, Stedden et al., 2019, Winberg et al., 1998)

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

62693

DroID - A comprehensive database of gene and protein interactions.

FBgn0016059

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

37007

MIST (protein-protein) - An integrated Molecular Interaction Database

Sema1b

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-83

Cytogenetic map

54D4-54D5

Sequence location

2R:17,672,839..17,683,499 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

54D4-54D5

Limits computationally determined from genome sequence between P{PZ}l(2)10505¹⁰⁵⁰⁵ and P{lacW}l(2)k07509^k07509&P{EP}CG10934^EP538

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-83

(FlyBase, 2016)

2-86.5

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (9)

Bloomington

28588

y¹ v¹; P{TRiP.HM05076}attP2

54550

y¹ w^*; Mi{MIC}Sema1b^MI10418

22506

y¹ w^67c23; P{EPgy2}Sema1b^EY21782

79314

y¹ w^*; TI{CRIMIC.TG4.2}Sema1b^{CR00845-TG4.2}

Kyoto

123465

w¹¹¹⁸; P{RS3}Sema1b^CB-5111-3

115463

w¹¹¹⁸; PBac{806.LOX-SVS-2}Sema1b^CPTI003971

103911

y^* w^*; P{GawB}Sema1b^NP1166 / CyO, P{UAS-lacZ.UW14}UW14

VDRC

v330391

P{VSH330391}attP40

v107233

P{KK104666}VIE-260B

Genomic Clones (31)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (113)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GH03186

Other clones

MIP07328

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0016059

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0016059

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

37007

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Sema1b Sema-1b

(FlyBase, 2009-)

Source for database merge of

Source for merge of: Sema-1b BcDNA:GH03186

(FlyBase, 1996-)

Additional comments

Source for merge of Sema-1b BcDNA:GH03186 was sequence comparison ( date:000114 ).

(FlyBase, 1996-)

Other Comments

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 43 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

37007

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0016059

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6446

Flygut - An atlas of the Drosophila adult midgut

FBgn0016059

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

37007

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC014179

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG6446

modMine - A data warehouse for the modENCODE project

FBgn0016059

Linkouts

BioGRID - A database of protein and genetic interactions.

62693

DroID - A comprehensive database of gene and protein interactions.

FBgn0016059

DRSC - Results frm RNAi screens

FBgn0016059

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0016059

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG6446-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0016059

FlyMine - An integrated database for Drosophila genomics

FBgn0016059

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

37007

MIST (protein-protein) - An integrated Molecular Interaction Database

Sema1b

Synonyms and Secondary IDs (15)

Reported As

Symbol Synonym

BcDNA:GH03186

CG6446

(Meadows, 2017.9.14, Keleman et al., 2009.8.5, Perkins et al., 2009, Hollien and Weissman, 2006, Rehwinkel et al., 2006)

D-semaIII

(Baumgartner et al., 1996)

Sema 1b

(Anonymous, 1999, Filbin, 1999)

Sema III

(Van Vactor and Lorenz, 1999)

Sema-1b

(Olson et al., 2019, Tegeder et al., 2019, Wolfram et al., 2014, Handke et al., 2013, Hazelett et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Hung et al., 2010, Kwon et al., 2008, Hollien and Weissman, 2006, Hollien and Weissman, 2006, Rehwinkel et al., 2006)

Sema1b

(Rozbesky et al., 2020, Wittes and Schüpbach, 2020.2.4, Wittes and Schüpbach, 2019, Gene Disruption Project members, 2018-, Syed et al., 2016, Nakahara and Carthew, 2004, Noordermeer et al., 1999, Winberg et al., 1999, Yu and Kolodkin, 1999, Winberg et al., 1998)

sema-III

(Baumgartner et al., 1996)

sema1b

(Yoo et al., 2016, Lawlor et al., 2011)

Name Synonyms

Sema-1b

Semaphorin 1b

semaphorin

(Dudu et al., 2004, Hughes and Salinas, 1999)

semaphorin-I

(Yu, 1997.6.6)

semaphorin-III

(Baumgartner et al., 1996)

semaphorin-like

(Rubin, 1999.8.27)

semiphorin

(Ackley and Jin, 2004)

Secondary FlyBase IDs

FBgn0023424
FBgn0028501

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (72)

The following external sites may use different assemblies or annotations than FlyBase.

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