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FB2021_04, released August 17, 2021

Gene: Dmel\Sema1b

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General Information
Symbol
Dmel\Sema1b
Species
D. melanogaster
Name
Semaphorin 1b
Annotation Symbol
CG6446
Feature Type
protein_coding_gene
FlyBase ID
FBgn0016059
Gene Model Status
Current
Stock Availability
9 publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

Sema-1b, Sema 1b, sema-III, semaphorin-like, semaphorin

Key Links
Genomic Location
Cytogenetic map
54D4-54D5
Sequence location
2R:17,672,839..17,683,499 [-]
Recombination map
2-83
RefSeq locus
NT_033778 REGION:17672839..17683499
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (10 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables chemorepellent activity
inferred from biological aspect of ancestor with PANTHER:PTN000867340
(assigned by GO_Central )
(Gaudet et al., 2011)
enables semaphorin receptor binding
inferred from biological aspect of ancestor with PANTHER:PTN000112368
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (6 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in embryonic development via the syncytial blastoderm
inferred from expression pattern
(Khare et al., 2000)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
involved_in axon guidance
inferred from biological aspect of ancestor with PANTHER:PTN000112368
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in negative chemotaxis
inferred from biological aspect of ancestor with PANTHER:PTN000744245
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in negative regulation of axon extension involved in axon guidance
inferred from biological aspect of ancestor with PANTHER:PTN000867340
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in positive regulation of cell migration
inferred from biological aspect of ancestor with PANTHER:PTN000867340
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in semaphorin-plexin signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN000112368
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in cytosol
inferred from high throughput direct assay
(Lye et al., 2014)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in extracellular space
inferred from biological aspect of ancestor with PANTHER:PTN000744245
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
SEMAPHORINS -
The Semaphorins are a family of membrane and secreted short-range signaling proteins, originally characterized for their role in axon guidance. The major signal transducing receptors for the semaphorins are the plexins. (Adapted from FBrf0233112, FBrf0137217 and PMID:23253452).
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Sema1b for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.50

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Sema1b-RA
FBtr0086890
NM_137400
4269
770
Sema1b-RB
FBtr0086891
NM_206157
4262
770
Sema1b-RC
FBtr0302161
NM_001169707
3910
770
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Sema1b-PA
FBpp0086050
85.2
770
6.96
NP_611244
AAF57816
Sema1b-PB
FBpp0089289
85.2
770
6.96
NP_995879
AAS64817
Sema1b-PC
FBpp0291371
85.2
770
6.96
NP_001163178
ACZ94450
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

770 aa isoforms: Sema1b-PA, Sema1b-PB, Sema1b-PC
Additional Polypeptide Data and Comments
Reported size (kDa)

759 (aa); 84 (kD predicted)

(Khare et al., 2000)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Sema1b using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 5 -- 6
mesectoderm
(Kearney et al., 2004)
embryonic stage 5 -- 7
ventral ectoderm

Comment: bilateral stripes, 1-2 cells wide

(Khare et al., 2000)
embryonic stage 7 -- 8
mesectoderm anlage
(Kearney et al., 2004)
embryonic stage 8 -- 10
ventral midline of embryo
(Khare et al., 2000)
embryonic stage 9 -- 12
midline primordium
(Kearney et al., 2004)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage & pupal stage
(Khare et al., 2000)
embryonic stage 2
organism | ubiquitous
(Khare et al., 2000)
embryonic stage 5 -- 10
mesectoderm
(Khare et al., 2000)
embryonic stage 12 -- 15
ectoderm
(Khare et al., 2000)
adult stageoogenesis stage S2 -- S8
ovariole
(Khare et al., 2000)
adult stage & oogenesis stage S10
nurse cell
(Khare et al., 2000)
Additional Descriptive Data

Sema1b transcripts are first expressed in early stages of oogenesis where staining is observed in ovarioles and nurse cells. In early embryos, staining is uniform. At stage 5, Sema1b transcripts are observed in two lateral stripes of 1-2 cells wide. These stripes meet at the ventral surface at stage 8 as a result of ventral furrow formation and may be mesectodermal cells. In later embryonic stages, staining is primarily in the ectoderm.

(Khare et al., 2000)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytosol
inferred from high throughput direct assay
(Lye et al., 2014)
Expression Deduced from Reporters
Reporter: P{GawB}Sema1bNP1166
Stage
Tissue/Position (including subcellular localization)
Reference
oogenesis
polar follicle cell
(Wittes and Schüpbach, 2019)
follicle cell

Comment: posterior follicle cell

(Wittes and Schüpbach, 2019)
Reporter: PBac{806.LOX-SVS-2}Sema1bCPTI003971
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
lamina
(Knowles-Barley, 2011.8.24)
adult brain cell body rind
(Knowles-Barley, 2011.8.24)
oogenesis
polar follicle cell
(Wittes and Schüpbach, 2019)
follicle cell

Comment: posterior follicle cell

(Wittes and Schüpbach, 2019)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Sema1b in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB
EMBL-EBI Single Cell Expression Atlas
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 8 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Sema1b
Transgenic constructs containing regulatory region of Sema1b
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(2R)Exel7149
(Ryder, 2004.4.26)
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (20)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\SEMA6A
7 of 15
Yes
No
Hsap\SEMA6B
7 of 15
Yes
Yes
Hsap\SEMA6D
7 of 15
Yes
No
Hsap\SEMA6C
6 of 15
No
Yes
Hsap\SEMA3A
3 of 15
No
No
Hsap\SEMA3B
3 of 15
No
No
Hsap\SEMA3C
3 of 15
No
No
Hsap\SEMA3D
3 of 15
No
No
Hsap\SEMA3E
3 of 15
No
No
Hsap\SEMA3F
3 of 15
No
No
Hsap\SEMA3G
3 of 15
No
No
Hsap\SEMA4D
3 of 15
No
No
Hsap\SEMA4A
2 of 15
No
No
1  
Hsap\SEMA4B
2 of 15
No
No
Hsap\SEMA4C
2 of 15
No
No
Hsap\SEMA4F
2 of 15
No
No
Hsap\SEMA4G
2 of 15
No
No
Hsap\SEMA7A
2 of 15
No
No
Hsap\SEMA5A
1 of 15
No
No
Hsap\SEMA5B
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (21)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Sema6a
7 of 15
Yes
No
Mmus\Sema6b
7 of 15
Yes
Yes
Mmus\Sema6d
7 of 15
Yes
No
Mmus\Sema6c
6 of 15
No
Yes
Mmus\Sema3a
3 of 15
No
No
Mmus\Sema3b
3 of 15
No
No
Mmus\Sema3c
3 of 15
No
No
Mmus\Sema3d
3 of 15
No
No
Mmus\Sema3e
3 of 15
No
No
Mmus\Sema3f
3 of 15
No
No
Mmus\Sema3g
3 of 15
No
No
Mmus\Sema4d
3 of 15
No
No
Mmus\Sema4a
2 of 15
No
No
Mmus\Sema4b
2 of 15
No
No
Mmus\Sema4c
2 of 15
No
No
Mmus\Sema4f
2 of 15
No
No
Mmus\Sema4g
2 of 15
No
No
Mmus\Sema7a
2 of 15
No
No
Mmus\Sema5a
1 of 15
No
No
Mmus\Sema5b
1 of 15
No
No
Mmus\Sspo
1 of 15
No
No
Rattus norvegicus (Norway rat) (20)
Rnor\Sema6a
7 of 13
Yes
Yes
Rnor\Sema6c
6 of 13
No
Yes
Rnor\Sema6b
5 of 13
No
Yes
Rnor\Sema6d
4 of 13
No
No
Rnor\Sema3a
3 of 13
No
No
Rnor\Sema3b
3 of 13
No
No
Rnor\Sema3c
3 of 13
No
No
Rnor\Sema3d
3 of 13
No
No
Rnor\Sema3e
3 of 13
No
No
Rnor\Sema3f
3 of 13
No
No
Rnor\Sema3g
3 of 13
No
No
Rnor\Sema4a
2 of 13
No
No
Rnor\Sema4c
2 of 13
No
No
Rnor\Sema4d
2 of 13
No
No
Rnor\Sema4f
2 of 13
No
No
Rnor\Sema4g
2 of 13
No
No
Rnor\Sema7a
2 of 13
No
No
Rnor\Sema4b
1 of 13
No
No
Rnor\Sema5a
1 of 13
No
No
Rnor\Sema5b
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (15)
Xtro\sema6d
5 of 12
Yes
No
Xtro\sema6a
4 of 12
No
No
Xtro\sema6b
4 of 12
No
Yes
Xtro\sema6c
4 of 12
No
No
Xtro\sema3b
3 of 12
No
No
Xtro\sema4d
3 of 12
No
No
Xtro\sema3a
2 of 12
No
No
Xtro\sema3c
2 of 12
No
No
Xtro\sema3d
2 of 12
No
No
Xtro\sema3f
2 of 12
No
No
Xtro\sema4a
2 of 12
No
No
Xtro\sema4b
2 of 12
No
No
Xtro\sema4c
2 of 12
No
No
Xtro\sema4g
2 of 12
No
No
Xtro\sema5b
1 of 12
No
No
Danio rerio (Zebrafish) (37)
Drer\sema6dl
8 of 15
Yes
Yes
Drer\sema6d
7 of 15
No
Yes
Drer\sema6e
7 of 15
No
Yes
Drer\sema6bb
6 of 15
No
Yes
Drer\sema6a
5 of 15
No
Yes
Drer\sema6ba
5 of 15
No
Yes
Drer\sema3b
4 of 15
No
No
Drer\sema3e
4 of 15
No
No
Drer\sema3h
4 of 15
No
No
Drer\sema3aa
3 of 15
No
No
Drer\sema3ab
3 of 15
No
No
Drer\sema3bl
3 of 15
No
No
Drer\sema3d
3 of 15
No
No
Drer\sema3fa
3 of 15
No
No
Drer\sema3fb
3 of 15
No
No
Drer\sema3ga
3 of 15
No
No
Drer\sema3gb
3 of 15
No
No
Drer\sema4e
3 of 15
No
No
Drer\si:ch211-129c21.1
3 of 15
No
No
Drer\si:dkey-49n23.1
3 of 15
No
No
Drer\LOC798168
2 of 15
No
No
Drer\sema3c
2 of 15
No
No
Drer\sema4ab
2 of 15
No
No
Drer\sema4ba
2 of 15
No
No
Drer\sema4c
2 of 15
No
No
Drer\sema4d
2 of 15
No
No
Drer\sema4ga
2 of 15
No
No
Drer\sema4gb
2 of 15
No
No
Drer\sema7a
2 of 15
No
No
Drer\si:ch211-113g11.6
2 of 15
No
No
Drer\LOC100537452
1 of 15
No
No
Drer\rttn
1 of 15
No
No
Drer\sema4bb
1 of 15
No
No
Drer\sema4f
1 of 15
No
No
Drer\sema5a
1 of 15
No
No
Drer\sema5ba
1 of 15
No
No
Drer\sema5bb
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (4)
Cele\smp-1
8 of 15
Yes
No
Cele\mab-20
2 of 15
No
No
Cele\smp-2
2 of 15
No
Yes
Cele\F23H12.5
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091902SQ )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00003078
Drosophila simulans
Dsim\GD25452
Drosophila sechellia
Dsec\GM19960
Drosophila erecta
Dere\GG21030
Drosophila yakuba
Dyak\GE13973
Drosophila ananassae
Dana\GF13235
Drosophila pseudoobscura pseudoobscura
Dpse\GA19600
Drosophila persimilis
Dper\GL17680
Drosophila willistoni
Dwil\GK15918
Drosophila virilis
Dvir\GJ21763
Drosophila mojavensis
Dmoj\GI18743
Drosophila grimshawi
Dgri\GH21142
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091502J9 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17018424
Glossina morsitans
Tsetse fly
Gmor\GMOY003361
Mayetiola destructor
Hessian fly
Mdes\Mdes009816
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL003063
Anopheles darlingi
American malaria mosquito
Adar\ADAC008907
Anopheles gambiae
Malaria mosquito
Agam\AGAP005742
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ000027
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W02B9 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA003697
Danaus plexippus
Monarch butterfly
Dple\DPOGS203791-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL012513
Apis florea
Little honeybee
Aflo\2147485265
Apis mellifera
Western honey bee
Amel\GB43476
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP20312
Bombus terrestris
Buff-tailed bumblebee
Bter\15214684
Linepithema humile
Argentine ant
Lhum\LH16031
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000c4c
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005201
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005204
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005203
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02477
Tribolium castaneum
Red flour beetle
Tcas\TC014179
Pediculus humanus
Human body louse
Phum\PHUM062540
Rhodnius prolixus
Kissing bug
Rpro\RPRC010471
Cimex lectularius
Bed bug
Clec\CLEC006275
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI001786
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_15414
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X03JM )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR012665
Strigamia maritima
European centipede
Smar\SMAR012278
Strigamia maritima
European centipede
Smar\SMAR004798
Ixodes scapularis
Black-legged tick
Isca\ISCW011583
Stegodyphus mimosarum
African social velvet spider
Smim\KFM69352.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM69353.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM72255.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur18g00820
Tetranychus urticae
Two-spotted spider mite
Turt\tetur18g00830
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_221078
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_328717
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0QST )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Ciona intestinalis
Vase tunicate
Cint\LOC100178887
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (4)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Sema1a
4 of 10
Sema2a
2 of 10
Sema2b
2 of 10
Sema5c
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    Sema1bKK104666
    exacerbates  atypical teratoid rhabdoid tumor
    modeled by Snr1KK101602
    (Tegeder et al., 2019)
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    SEMA6A; semaphorin 6A
    7 of 15
    605885
        SEMA6B; semaphorin 6B
        7 of 15
        608873
          SEMA6D; semaphorin 6D
          7 of 15
          609295
              SEMA6C; semaphorin 6C
              6 of 15
              609294
                  SEMA3A; semaphorin 3A
                  3 of 15
                  603961
                  SEMA3B; semaphorin 3B
                  3 of 15
                  601281
                      SEMA3C; semaphorin 3C
                      3 of 15
                      602645
                          SEMA3D; semaphorin 3D
                          3 of 15
                          609907
                              SEMA3E; semaphorin 3E
                              3 of 15
                              608166
                              SEMA3F; semaphorin 3F
                              3 of 15
                              601124
                                  SEMA3G; semaphorin 3G
                                  3 of 15
                                      SEMA4D; semaphorin 4D
                                      3 of 15
                                      601866
                                          Functional Complementation Data
                                          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                          Interactions
                                          Summary of Physical Interactions
                                          esyN Network Diagram
                                          Show neighbor-neighbor interactions:
                                          Select Layout:
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                                          Protein
                                          RNA
                                          Selected Interactor(s)
                                          Interactions Browser
                                          View in Interactions Browser
                                          Please see the Physical Interaction reports below for full details
                                          protein-protein
                                          Physical Interaction
                                          Assay
                                          References
                                          Sema1b - PlexA
                                          enzyme linked immunosorbent assay, x-ray crystallography, microscale thermophoresis, predetermined participant, molecular sieving, light scattering, fluorescent resonance energy transfer, fluorescence microscopy
                                          (Rozbesky et al., 2020, Rozbesky et al., 2019, Stedden et al., 2019, Winberg et al., 1998)
                                          Summary of Genetic Interactions
                                          esyN Network Diagram
                                          Starting gene(s)
                                          Interaction type
                                          Interacting gene(s)
                                          Reference
                                          Starting gene(s)
                                          Interaction type
                                          Interacting gene(s)
                                          Reference
                                          External Data
                                          Linkouts
                                          BioGRID - A database of protein and genetic interactions.
                                          DroID - A comprehensive database of gene and protein interactions.
                                          MIST (protein-protein) - An integrated Molecular Interaction Database
                                          Pathways
                                          Signaling Pathways (FlyBase)
                                          Metabolic Pathways
                                          External Data
                                          Linkouts
                                          Genomic Location and Detailed Mapping Data
                                          Chromosome (arm)
                                          2R
                                          Recombination map
                                          2-83
                                          Cytogenetic map
                                          54D4-54D5
                                          Sequence location
                                          2R:17,672,839..17,683,499 [-]
                                          FlyBase Computed Cytological Location
                                          Cytogenetic map
                                          Evidence for location
                                          54D4-54D5
                                          Limits computationally determined from genome sequence between P{PZ}l(2)1050510505 and P{lacW}l(2)k07509k07509&P{EP}CG10934EP538
                                          Experimentally Determined Cytological Location
                                          Cytogenetic map
                                          Notes
                                          References
                                          Experimentally Determined Recombination Data
                                          Location

                                          2-83

                                          (FlyBase, 2016)

                                          2-86.5

                                          (Comeron et al., 2012)
                                          Left of (cM)
                                          Right of (cM)
                                          Notes
                                          Stocks and Reagents
                                          Stocks (9)
                                          Genomic Clones (31)
                                          cDNA Clones (113)
                                           

                                          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                                          cDNA clones, fully sequenced
                                          BDGP DGC clones
                                          Other clones
                                          Drosophila Genomics Resource Center cDNA clones

                                          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                          cDNA Clones, End Sequenced (ESTs)
                                          BDGP DGC clones
                                          Other clones
                                          RNAi and Array Information
                                          Linkouts
                                          DRSC - Results frm RNAi screens
                                          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                          Antibody Information
                                          Laboratory Generated Antibodies
                                           
                                          Commercially Available Antibodies
                                           
                                          Other Information
                                          Relationship to Other Genes
                                          Source for database identify of

                                          Source for identity of: Sema1b Sema-1b

                                          (FlyBase, 2009-)
                                          Source for database merge of

                                          Source for merge of: Sema-1b BcDNA:GH03186

                                          (FlyBase, 1996-)
                                          Additional comments

                                          Source for merge of Sema-1b BcDNA:GH03186 was sequence comparison ( date:000114 ).

                                          (FlyBase, 1996-)
                                          Other Comments
                                          Origin and Etymology
                                          Discoverer
                                          Etymology
                                          Identification
                                          External Crossreferences and Linkouts ( 44 )
                                          Sequence Crossreferences
                                          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                          Other crossreferences
                                          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                          DRscDB
                                          EMBL-EBI Single Cell Expression Atlas
                                          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                          Flygut - An atlas of the Drosophila adult midgut
                                          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                          InterPro - A database of protein families, domains and functional sites
                                          KEGG Genes - Molecular building blocks of life in the genomic space.
                                          MARRVEL_MODEL
                                          modMine - A data warehouse for the modENCODE project
                                          Linkouts
                                          BioGRID - A database of protein and genetic interactions.
                                          DroID - A comprehensive database of gene and protein interactions.
                                          DRSC - Results frm RNAi screens
                                          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                          FlyMine - An integrated database for Drosophila genomics
                                          MIST (protein-protein) - An integrated Molecular Interaction Database
                                          Synonyms and Secondary IDs (15)
                                          Datasets (0)
                                          Study focus (0)
                                          Experimental Role
                                          Project
                                          Project Type
                                          Title
                                          References (73)