• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\wun

General Information
Symbol	Dmel\wun	Species	D. melanogaster
Name	wunen	Annotation symbol	CG8804
Feature type	protein_coding_gene	FlyBase ID	FBgn0016078
Gene Model Status	Current	Stock availability	25 publicly available
Also Known As	l(2)k16806
Genomic Location
Chromosome (arm)	2R	Recombination map	2-
Cytogenetic map	45D3-45D4	Sequence location	2R:5,288,036..5,300,965 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene wunen is referred to in FlyBase by the symbol Dmel\wun (CG8804, FBgn0016078). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: phosphatase activity. There is experimental evidence that it is involved in the biological process: germ cell migration; germ cell repulsion. 43 alleles are reported. The phenotypes of these alleles are annotated with: bouton; embryonic proventriculus; germline cell; intersegmental nerve; presumptive embryonic/larval digestive system; synapse. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Phosphatidic acid phosphatase type 2/haloperoxidase; Phosphatidic acid phosphatase/chloroperoxidase, N-terminal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 12-18 embryonic stages, during late larval stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult crop, adult hindgut, adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, larval/adult midgut, larval hindgut, larval/adult Malpighian tubules, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1631573_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of wun. Gene sequence location is 2R:5288036..5300965.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Alleles wun[49] Sequence features BKN60070 BKN60139 HFA07719 BKN20765
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 45D3-45D4   Limits computationally determined from genome sequence between P{lacW}Pknk11209 and P{lacW}wunk09507&P{lacW}l(2)k12402k12402
Experimentally Determined Cytological Location
Cytogenetic map Notes References 45D4-45D5   (determined by in situ hybridisation)   (Spradling et al., 1999) 45D4-45D5   (determined by in situ hybridisation)   (Zhang et al., 1996) 45D4-45D5     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	2- (Zhang et al., 1996)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\wun for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	EST data suggest additional 3' exon(s)
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) wun-RA FBtr0088553  NM_057845   1588   300 wun-RB FBtr0088552  NM_165674   2023   379 wun-RC FBtr0306111     1560   364
Additional Transcript Data & Comments
Reported size (kB)	1.622 (longest cDNA) (Zhang et al., 1997)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein wun-PA   FBpp0087636   33.9   300   9.11     NP_477193   AAM71066 wun-PB   FBpp0087635   42.8   379   8.45     NP_724787   AAF58942 wun-PC   FBpp0297248   41.3   364   8.95
Additional Polypeptide Data & Comments
Reported size (kDa)	300 (aa) (Zhang et al., 1997)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Phosphatidic acid phosphatase type 2/haloperoxidase (IPR000326) Phosphatidic acid phosphatase/chloroperoxidase, N-terminal (IPR016118)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA940783   AE013599 AAF58942   AE013599 AAM71066   AC008341   AF145595 AAD38570   AI062852   AI401851   AI514677   AI518107   AQ025894   AQ026117   AQ073398   AQ073721   AY046533 AAL34392   BI164505   BI216140   BI241795   BI370211   BI374044   BI486317   BI486929   BI580438   BP557646   BT001729 AAN71484   BT099641   CK659648   CK659964   CO191706   CO191753   CO276346   CO320936   CO335632   CW848181   CZ471901   CZ473592   CZ473687   EC051723   EC052206   EC054646   EC054650   EC055944   EC066749   EC204786   EC208943   EC265914   GH748380   GH749593   GH750017   GH750066   GH750191   GH751838   GH751915   GH752218   GH753350   GH753420   GH754546   GH755158   GH755546   GH755569   GH756734   GH757588   GH758162   GH759327   GH760283   GH761141   GH770890   GH771435   GH771919   GH773261   GH774248   GH774762   GH776173   GH780034   GH781232   GH782070   GH783619   GH783849   GH786156   GH786613   GH788330   GH788496   GH790111   GH792526   GH792836   GH793138   GH795408   GH795977   GH796351   GH797064   GH798768   GH798874   GH799981   GH800150   GH800899   GH801679   GH801958   GH802523   GH803567   GH805691   GH806512   GH807694   GH808680   GH809587   GH811425   GH811946   GH815968   GH817573   GH817643   GH818165   GH819276   GH820722   GH821140   GH822157   GH823818   GH824132   GH824522   GH825217   GH826006   GH828459   GH832292   GH833203   GH835464   GH835625   GH836672   GH838788   GH842496   GH843863   GH844151   GH844648   GH845019   GH846933   GH851387   GH853353   GH854901   GH858046   GH858856   GH859772   GH860567   GH860648   GH860695   GH861362   GH861585   GH861684   GH861710   GH863232   GH864420   GH865220   GH865391   GH865620   GH865956   GH866680   GH873575   GH875129   GH875179   GH877131   GH877897   GH878152   GH878346   GH880725   GH884947   GH885307   GH886047   GH886363   GH887600   GH888346   GH889977   GH890515   GH891539   GH892457   GH893763   GH895042   GH895903   GH896672   GH901976   GH902101   GH904270   GH904609   GH907333   GH907814   GH910472   GH910897   GH911325   GH911375   GH912024   GH912158   GH913695   GH914135   GH916279   GH917106   GH917701   GH918489   GH918542   GH921985   GH923232   GH926751   GH927090   GH930598   GH930966   GH933233   GH935512   GH938371   U73822 AAC47449   Z71084
UniProtKB/Swiss-Prot	Q9V576
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   posterior midgut primordium | dorsal   (Zhang et al., 1997) ectoderm | restricted   (Zhang et al., 1997) inclusive hindgut primordium   (Zhang et al., 1997) embryonic stage | late   presumptive embryonic/larval central nervous system   (Zhang et al., 1997) embryonic stage 10   posterior midgut primordium | restricted   (Starz-Gaiano et al., 2001) Comment:excludes part where germ cells exit the gut hindgut proper primordium   (Starz-Gaiano et al., 2001) anterior midgut primordium   (Starz-Gaiano et al., 2001) embryonic stage 10 -- 12   neuroblast | lateral & subset   (Starz-Gaiano et al., 2001) embryonic stage 10 -- 13   epidermis | segmentally repeated   (Starz-Gaiano et al., 2001)
Additional Descriptive Data
	wun transcripts are first expressed at high levels in the hindgut primordium, and are expressed in a segmentally repeated pattern in the ectoderm. They are later expressed on the dorsal side of the posterior midgut. In germ band extended embryos, wun is expressed in the ectoderm in a medial band throughout the trunk. In germ band retracted embryos, wun is expressed in the gut, nervous system, and ectoderm. (Zhang et al., 1997)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0016078    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0016078 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 12-18 embryonic stages, during late larval stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0016078 expression level Developmental Stage   Expression Level embryo 00-02hr    1511 embryo 02-04hr    1312 embryo 04-06hr    1243 embryo 06-08hr    1338 embryo 08-10hr    1846 embryo 10-12hr    2936 embryo 12-14hr    3163 embryo 14-16hr    4054 embryo 16-18hr    4937 embryo 18-20hr    3398 embryo 20-22hr    3069 embryo 22-24hr    3493 larva L1    1983 larva L2    1614 larva L3 12hr old    1068 larva L3 puffstage 1-2    1458 larva L3 puffstage 3-6    2551 larva L3 puffstage 7-9    4743 white prepupae new    6198 white prepupae 12hr    3400 white prepupae 24hr    2051 pupae 2d postWPP    1487 pupae 3d postWPP    1263 pupae 4d postWPP    3731 adult male 01day    1590 adult male 05day    1547 adult male 30day    1768 adult female 01day    1985 adult female 05day    1803 adult female 30day    1835 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1511) embryo 02-04hr  (1312) embryo 04-06hr  (1243) embryo 06-08hr  (1338) embryo 08-10hr  (1846) embryo 10-12hr  (2936) embryo 12-14hr  (3163) embryo 14-16hr  (4054) embryo 16-18hr  (4937) embryo 18-20hr  (3398) embryo 20-22hr  (3069) embryo 22-24hr  (3493) larva L1  (1983) larva L2  (1614) larva L3 12hr old  (1068) larva L3 puffstage 1-2  (1458) larva L3 puffstage 3-6  (2551) larva L3 puffstage 7-9  (4743) white prepupae new  (6198) white prepupae 12hr  (3400) white prepupae 24hr  (2051) pupae 2d postWPP  (1487) pupae 3d postWPP  (1263) pupae 4d postWPP  (3731) adult male 01day  (1590) adult male 05day  (1547) adult male 30day  (1768) adult female 01day  (1985) adult female 05day  (1803) adult female 30day  (1835) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (1511) embryo 02-04hr    1312 embryo 04-06hr    1243 embryo 06-08hr    1338 embryo 08-10hr  (1846) embryo 10-12hr  (2936) embryo 12-14hr  (3163) embryo 14-16hr  (4054) embryo 16-18hr  (4937) embryo 18-20hr  (3398) embryo 20-22hr  (3069) embryo 22-24hr  (3493) larva L1  (1983) larva L2  (1614) larva L3 12hr old    1068 larva L3 puffstage 1-2  1458 larva L3 puffstage 3-6  (2551) larva L3 puffstage 7-9  (4743) white prepupae new  (6198) white prepupae 12hr  (3400) white prepupae 24hr  (2051) pupae 2d postWPP  1487 pupae 3d postWPP    1263 pupae 4d postWPP  (3731) adult male 01day  (1590) adult male 05day  (1547) adult male 30day  (1768) adult female 01day  (1985) adult female 05day  (1803) adult female 30day  (1835) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1511 embryo 02-04hr    1312 embryo 04-06hr    1243 embryo 06-08hr    1338 embryo 08-10hr    1846 embryo 10-12hr    2936 embryo 12-14hr    3163 embryo 14-16hr    4054 embryo 16-18hr    4937 embryo 18-20hr    3398 embryo 20-22hr    3069 embryo 22-24hr    3493 larva L1    1983 larva L2    1614 larva L3 12hr old    1068 larva L3 puffstage 1-2    1458 larva L3 puffstage 3-6    2551 larva L3 puffstage 7-9    4743 white prepupae new    6198 white prepupae 12hr    3400 white prepupae 24hr    2051 pupae 2d postWPP    1487 pupae 3d postWPP    1263 pupae 4d postWPP    3731 adult male 01day    1590 adult male 05day    1547 adult male 30day    1768 adult female 01day    1985 adult female 05day    1803 adult female 30day    1835 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1511 embryo 02-04hr    1312 embryo 04-06hr    1243 embryo 06-08hr    1338 embryo 08-10hr    1846 embryo 10-12hr    2936 embryo 12-14hr    3163 embryo 14-16hr    4054 embryo 16-18hr    4937 embryo 18-20hr    3398 embryo 20-22hr    3069 embryo 22-24hr    3493 larva L1    1983 larva L2    1614 larva L3 12hr old    1068 larva L3 puffstage 1-2    1458 larva L3 puffstage 3-6    2551 larva L3 puffstage 7-9    4743 white prepupae new    6198 white prepupae 12hr    3400 white prepupae 24hr    2051 pupae 2d postWPP    1487 pupae 3d postWPP    1263 pupae 4d postWPP    3731 adult male 01day    1590 adult male 05day    1547 adult male 30day    1768 adult female 01day    1985 adult female 05day    1803 adult female 30day    1835 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0016078 expression level Developmental Stage   Expression Level embryo 00-02hr    1511 embryo 02-04hr    1312 embryo 04-06hr    1243 embryo 06-08hr    1338 embryo 08-10hr    1846 embryo 10-12hr    2936 embryo 12-14hr    3163 embryo 14-16hr    4054 embryo 16-18hr    4937 embryo 18-20hr    3398 embryo 20-22hr    3069 embryo 22-24hr    3493 larva L1    1983 larva L2    1614 larva L3 12hr old    1068 larva L3 puffstage 1-2    1458 larva L3 puffstage 3-6    2551 larva L3 puffstage 7-9    4743 white prepupae new    6198 white prepupae 12hr    3400 white prepupae 24hr    2051 pupae 2d postWPP    1487 pupae 3d postWPP    1263 pupae 4d postWPP    3731 adult male 01day    1590 adult male 05day    1547 adult male 30day    1768 adult female 01day    1985 adult female 05day    1803 adult female 30day    1835 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1511) embryo 02-04hr  (1312) embryo 04-06hr  (1243) embryo 06-08hr  (1338) embryo 08-10hr  (1846) embryo 10-12hr  (2936) embryo 12-14hr  (3163) embryo 14-16hr  (4054) embryo 16-18hr  (4937) embryo 18-20hr  (3398) embryo 20-22hr  (3069) embryo 22-24hr  (3493) larva L1  (1983) larva L2  (1614) larva L3 12hr old  (1068) larva L3 puffstage 1-2  (1458) larva L3 puffstage 3-6  (2551) larva L3 puffstage 7-9  (4743) white prepupae new  (6198) white prepupae 12hr  (3400) white prepupae 24hr  (2051) pupae 2d postWPP  (1487) pupae 3d postWPP  (1263) pupae 4d postWPP  (3731) adult male 01day  (1590) adult male 05day  (1547) adult male 30day  (1768) adult female 01day  (1985) adult female 05day  (1803) adult female 30day  (1835) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1511 embryo 02-04hr    1312 embryo 04-06hr    1243 embryo 06-08hr    1338 embryo 08-10hr  1846 embryo 10-12hr  (2936) embryo 12-14hr  (3163) embryo 14-16hr  (4054) embryo 16-18hr  (4937) embryo 18-20hr  (3398) embryo 20-22hr  (3069) embryo 22-24hr  (3493) larva L1  1983 larva L2  1614 larva L3 12hr old    1068 larva L3 puffstage 1-2  1458 larva L3 puffstage 3-6  (2551) larva L3 puffstage 7-9  (4743) white prepupae new  (6198) white prepupae 12hr  (3400) white prepupae 24hr  2051 pupae 2d postWPP  1487 pupae 3d postWPP    1263 pupae 4d postWPP  (3731) adult male 01day  1590 adult male 05day  1547 adult male 30day  1768 adult female 01day  1985 adult female 05day  1803 adult female 30day  1835 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1511 embryo 02-04hr    1312 embryo 04-06hr    1243 embryo 06-08hr    1338 embryo 08-10hr    1846 embryo 10-12hr    2936 embryo 12-14hr    3163 embryo 14-16hr    4054 embryo 16-18hr    4937 embryo 18-20hr    3398 embryo 20-22hr    3069 embryo 22-24hr    3493 larva L1    1983 larva L2    1614 larva L3 12hr old    1068 larva L3 puffstage 1-2    1458 larva L3 puffstage 3-6    2551 larva L3 puffstage 7-9    4743 white prepupae new    6198 white prepupae 12hr    3400 white prepupae 24hr    2051 pupae 2d postWPP    1487 pupae 3d postWPP    1263 pupae 4d postWPP    3731 adult male 01day    1590 adult male 05day    1547 adult male 30day    1768 adult female 01day    1985 adult female 05day    1803 adult female 30day    1835 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1511 embryo 02-04hr    1312 embryo 04-06hr    1243 embryo 06-08hr    1338 embryo 08-10hr    1846 embryo 10-12hr    2936 embryo 12-14hr    3163 embryo 14-16hr    4054 embryo 16-18hr    4937 embryo 18-20hr    3398 embryo 20-22hr    3069 embryo 22-24hr    3493 larva L1    1983 larva L2    1614 larva L3 12hr old    1068 larva L3 puffstage 1-2    1458 larva L3 puffstage 3-6    2551 larva L3 puffstage 7-9    4743 white prepupae new    6198 white prepupae 12hr    3400 white prepupae 24hr    2051 pupae 2d postWPP    1487 pupae 3d postWPP    1263 pupae 4d postWPP    3731 adult male 01day    1590 adult male 05day    1547 adult male 30day    1768 adult female 01day    1985 adult female 05day    1803 adult female 30day    1835 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0016078    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0016078 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult crop, adult hindgut, adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, larval/adult midgut, larval hindgut, larval/adult Malpighian tubules, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0016078 expression level Tissue   Expression Level Larval Central Nervous System    74.9 Larval Midgut    259.7 Larval Hindgut    207.6 Larval Malpighian Tubules    198 Larval Fat Body no informative data Larval Salivary Gland    73.3 Larval Trachea    70 Larval Carcass    144.9 Adult Head    137.8 Adult Eye    108.65 Adult Brain    217.1 Adult Thoracic-Abdominal Ganglion    268.6 Adult Crop    781.6 Adult Midgut    266.5 Adult Hindgut    515.7 Adult Malpighian Tubules    203.4 Adult Fat Body    68.8 Adult Salivary Gland    804.1 Adult Heart    86.975 Adult VirginFemale Spermatheca    64.9 Adult InseminatedFemale Spermatheca    68.9 Adult Ovary    86 Adult Testis    27.5 Adult Male Accessory Gland    84.3 Adult Carcass    89.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    74.9 Larval Midgut    259.7 Larval Hindgut    207.6 Larval Malpighian Tubules    198 Larval Fat Body no informative data Larval Salivary Gland    73.3 Larval Trachea    70 Larval Carcass    144.9 Adult Head    137.8 Adult Eye    108.65 Adult Brain    217.1 Adult Thoracic-Abdominal Ganglion    268.6 Adult Crop  (781.6) Adult Midgut    266.5 Adult Hindgut  515.7 Adult Malpighian Tubules    203.4 Adult Fat Body    68.8 Adult Salivary Gland  (804.1) Adult Heart    86.975 Adult VirginFemale Spermatheca    64.9 Adult InseminatedFemale Spermatheca    68.9 Adult Ovary    86 Adult Testis    27.5 Adult Male Accessory Gland    84.3 Adult Carcass    89.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    74.9 Larval Midgut    259.7 Larval Hindgut    207.6 Larval Malpighian Tubules    198 Larval Fat Body no informative data Larval Salivary Gland    73.3 Larval Trachea    70 Larval Carcass    144.9 Adult Head    137.8 Adult Eye    108.65 Adult Brain    217.1 Adult Thoracic-Abdominal Ganglion    268.6 Adult Crop    781.6 Adult Midgut    266.5 Adult Hindgut    515.7 Adult Malpighian Tubules    203.4 Adult Fat Body    68.8 Adult Salivary Gland    804.1 Adult Heart    86.975 Adult VirginFemale Spermatheca    64.9 Adult InseminatedFemale Spermatheca    68.9 Adult Ovary    86 Adult Testis    27.5 Adult Male Accessory Gland    84.3 Adult Carcass    89.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    74.9 Larval Midgut    259.7 Larval Hindgut    207.6 Larval Malpighian Tubules    198 Larval Fat Body no informative data Larval Salivary Gland    73.3 Larval Trachea    70 Larval Carcass    144.9 Adult Head    137.8 Adult Eye    108.65 Adult Brain    217.1 Adult Thoracic-Abdominal Ganglion    268.6 Adult Crop    781.6 Adult Midgut    266.5 Adult Hindgut    515.7 Adult Malpighian Tubules    203.4 Adult Fat Body    68.8 Adult Salivary Gland    804.1 Adult Heart    86.975 Adult VirginFemale Spermatheca    64.9 Adult InseminatedFemale Spermatheca    68.9 Adult Ovary    86 Adult Testis    27.5 Adult Male Accessory Gland    84.3 Adult Carcass    89.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0016078 expression level Tissue   Expression Level Larval Central Nervous System    74.9 Larval Midgut    259.7 Larval Hindgut    207.6 Larval Malpighian Tubules    198 Larval Fat Body no informative data Larval Salivary Gland    73.3 Larval Trachea    70 Larval Carcass    144.9 Adult Head    137.8 Adult Eye    108.65 Adult Brain    217.1 Adult Thoracic-Abdominal Ganglion    268.6 Adult Crop    781.6 Adult Midgut    266.5 Adult Hindgut    515.7 Adult Malpighian Tubules    203.4 Adult Fat Body    68.8 Adult Salivary Gland    804.1 Adult Heart    86.975 Adult VirginFemale Spermatheca    64.9 Adult InseminatedFemale Spermatheca    68.9 Adult Ovary    86 Adult Testis    27.5 Adult Male Accessory Gland    84.3 Adult Carcass    89.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    74.9 Larval Midgut    259.7 Larval Hindgut    207.6 Larval Malpighian Tubules    198 Larval Fat Body no informative data Larval Salivary Gland    73.3 Larval Trachea    70 Larval Carcass    144.9 Adult Head    137.8 Adult Eye    108.65 Adult Brain    217.1 Adult Thoracic-Abdominal Ganglion    268.6 Adult Crop  781.6 Adult Midgut    266.5 Adult Hindgut  515.7 Adult Malpighian Tubules    203.4 Adult Fat Body    68.8 Adult Salivary Gland  804.1 Adult Heart    86.975 Adult VirginFemale Spermatheca    64.9 Adult InseminatedFemale Spermatheca    68.9 Adult Ovary    86 Adult Testis    27.5 Adult Male Accessory Gland    84.3 Adult Carcass    89.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    74.9 Larval Midgut    259.7 Larval Hindgut    207.6 Larval Malpighian Tubules    198 Larval Fat Body no informative data Larval Salivary Gland    73.3 Larval Trachea    70 Larval Carcass    144.9 Adult Head    137.8 Adult Eye    108.65 Adult Brain    217.1 Adult Thoracic-Abdominal Ganglion    268.6 Adult Crop    781.6 Adult Midgut    266.5 Adult Hindgut    515.7 Adult Malpighian Tubules    203.4 Adult Fat Body    68.8 Adult Salivary Gland    804.1 Adult Heart    86.975 Adult VirginFemale Spermatheca    64.9 Adult InseminatedFemale Spermatheca    68.9 Adult Ovary    86 Adult Testis    27.5 Adult Male Accessory Gland    84.3 Adult Carcass    89.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    74.9 Larval Midgut    259.7 Larval Hindgut    207.6 Larval Malpighian Tubules    198 Larval Fat Body no informative data Larval Salivary Gland    73.3 Larval Trachea    70 Larval Carcass    144.9 Adult Head    137.8 Adult Eye    108.65 Adult Brain    217.1 Adult Thoracic-Abdominal Ganglion    268.6 Adult Crop    781.6 Adult Midgut    266.5 Adult Hindgut    515.7 Adult Malpighian Tubules    203.4 Adult Fat Body    68.8 Adult Salivary Gland    804.1 Adult Heart    86.975 Adult VirginFemale Spermatheca    64.9 Adult InseminatedFemale Spermatheca    68.9 Adult Ovary    86 Adult Testis    27.5 Adult Male Accessory Gland    84.3 Adult Carcass    89.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    137.8   NA  Eye    108.65   NA  Brain    217.1   74.9  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    268.6   NA  Crop    781.6   259.7  Midgut    266.5   207.6  Hindgut    515.7   198  Malpighian Tubules    203.4   no informative data  Fat Body    68.8   73.3  Salivary Gland    804.1   NA  Heart    86.975   70  Trachea    NA   NA  VirginFemale Spermatheca    64.9   NA  InseminatedFemale Spermatheca    68.9   NA  Ovary    86   NA  Testis    27.5   NA  Male Accessory Gland    84.3   144.9  Carcass    89.5 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_25
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0016078 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8804-RB FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for wun Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | recessive wunEMS4 wunEMS23 wunEMS41 wunk09507 wunk10201 wunk15909 wunk16806 semi-lethal wunEMS9 viable wunEY11935 viable, with Scer\GAL4[-]: wunEP2607 viable, with Scer\GAL4pnr-MD237 wunGD1640 Sterility Allele female sterile wunCE wunCN wunEMS9 fertile wunEY11935 Other Phenotypes Allele neuroanatomy defective wunk09507 neuroanatomy defective | larval stage, with Scer\GAL4elav-C155 wunEP2208 wild-type wun+tNN Phenotype manifest in Allele anterior fascicle & synapse, with Scer\GAL4elav-C155 wunEP2208 anterior fascicle & synapse | supernumerary, with Scer\GAL4elav-C155 wunEP2208 bouton wunk09507 embryonic proventriculus (with Df(2R)wun-GL) wunk15909 germline cell wunCE wunCN germline cell, with Scer\GAL4[-]: wunEP2607 germline cell, with Scer\GAL4how-24B, Scer\GAL4twi.PG wunScer\UAS.cZa germline cell, with Scer\GAL4twi.PG wunScer\UAS.T:Avic\GFP-EGFP germline cell | embryonic stage | male wunCE germline cell | female wunk10201 germline cell | female, with Scer\GAL4twi.PG wunScer\UAS.cZa germline cell | male wunk10201 germline cell | male, with Scer\GAL4twi.PG wunScer\UAS.cZa intersegmental nerve, with Scer\GAL4elav-C155 wunEP2208 presumptive embryonic/larval digestive system (with Df(2R)wun-GL) wunk15909 synapse wunk09507
Classical Alleles ( 34 )
For All Classical Alleles Show
Allele of wun Class Mutagen Stocks Known lesion wunk10201 loss of function allele P-element activity 2 Yes wunk16806 P-element activity 2 Yes wun5-HA-1200 1 -- wun5-HA-2881 1 -- wunc01445 1 -- wune02143 1 -- wunEMS23 ethyl methanesulfonate 1 -- wunEMS41 ethyl methanesulfonate 1 -- wunEMS4 ethyl methanesulfonate 1 -- wunEY11935 P-element activity 1 -- wunk09507 P-element activity 1 Yes wunk15909 P-element activity 1 -- wunNP0855 1 -- wunNP1243 1 -- wunNP2127 1 -- wunNP3279 1 -- wunNP5293 1 -- wun49 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes wun5-HA-2269 0 -- wun5-HA-2275 0 -- wunCE loss of function allele 0 -- wunCN 0 Yes wund00931 P-element activity 0 -- wund03854 P-element activity 0 -- wund04014 P-element activity 0 -- wunEMS9 ethyl methanesulfonate 0 -- wunEP2208 P-element activity 0 Yes wunEP2525 0 -- wunEP2607 P-element activity 0 Yes wunEP2650ex34 Delta2-3 0 Yes wunEP652 P-element activity 0 -- wunGS10009 0 Yes wunk12382 0 -- wunPBacF48 0 --
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of wun Class Mutagen Stocks Known lesion wunGD15706 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes wunGD1640 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes wunHMS00424 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes wunHMS00425 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes wun+tNN in vitro construct - genomic fragment 0 Yes wunD248T.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes wunNX in vitro construct - genomic fragment 0 Yes wunScer\UAS.cZa in vitro construct - regulatory fusion 0 Yes wunScer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)11 (Kozopas, 2003.3) Df(2R)Np5 (Spradling et al., 1999, Kozopas, 2003.3, BDGP Project Members, 1994-1999, Zhang et al., 1996) Df(2R)NYX-D15 (Sano et al., 2005) Df(2R)w45-30n (BDGP Project Members, 1994-1999, Zhang et al., 1996) Df(2R)w73-1 (Zhang et al., 1996) Df(2R)wun-GL (Matthews, 1996.2.2, Zhang et al., 1996, Sano et al., 2005) In(2LR)TE35B-15LL2R (Zhang et al., 1996) In(2R)G63Lw45-73nR (Zhang et al., 1996)
Not disrupted in	Df(2R)H3C1 (Zhang et al., 1996) Df(2R)H3D3 (Zhang et al., 1996) Df(2R)H3E1 (Zhang et al., 1996) Df(2R)NCX10 (Zhang et al., 1996) Df(2R)NCX11 (Zhang et al., 1996) Df(2R)Np1 (Spradling et al., 1999, BDGP Project Members, 1994-1999, Zhang et al., 1996) Df(2R)Np3 (Spradling et al., 1999, BDGP Project Members, 1994-1999, Zhang et al., 1996) Df(2R)Np4 (Spradling et al., 1999, BDGP Project Members, 1994-1999, Zhang et al., 1996) Df(2R)P14TE (Zhang et al., 1996) Df(2R)w45-30n (BDGP Project Members, 1994-1999) Df(2R)w73-1 (BDGP Project Members, 1994-1999, Zhang et al., 1996) Df(2R)wun-GL (Zhang et al., 1996) Df(2R)XE-916 (BDGP Project Members, 1994-1999) In(2LR)TE35B-15 (Zhang et al., 1996) In(2R)G63Lw45-73nR (Spradling et al., 1999, BDGP Project Members, 1994-1999, Zhang et al., 1996)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1640} NA P{GD15706} NA P{TRiP.HMS00424} NA P{TRiP.HMS00425} NA P{UAS-wun.D248T.GFP} NA P{UAS-wun.EGFP} NA P{UAS-wun.Z} NA characterization construct P{NN} NA P{NX} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}l(2)SH0273SH0273 No P{lacW}wunk09507 No P{lacW}wunk10201 No P{lacW}wunk15909 No P{lacW}wunk16806 No P{PZ}l(2)0349703497 No insertion of mobile activating element P{EP}wunEP652 NA P{EP}wunEP2208 NA P{EP}wunEP2525 NA P{EP}wunEP2607 NA P{EPgy2}wunEY11935 NA P{GSV6}wunGS10009 NA P{XP}wund00931 NA P{XP}wund03854 NA P{XP}wund04014 NA miscellaneous insertions P{RS5}wun5-HA-1200 NA P{RS5}wun5-HA-2269 NA P{RS5}wun5-HA-2275 NA P{RS5}wun5-HA-2881 NA PBac{3xP3-EYFP,p-tTA-K10}wunPBacF48 NA PBac{PB}wunc01445 NA PBac{RB}wune02143 NA insertion of enhancer trap binary system P{GawB}wunNP0855 No P{GawB}wunNP1243 No P{GawB}wunNP2127 No P{GawB}wunNP3279 No P{GawB}wunNP5293 No
Gene Ontology: Function, Process & Cellular Component ( 12 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function
CV term Evidence References
phosphatase activity inferred from direct assay (Burnett and Howard, 2003)
Biological Process
CV term Evidence References
germ cell migration inferred from mutant phenotype (Sano et al., 2005) germ cell repulsion inferred from genetic interaction with wun2 (Renault et al., 2010) inferred from mutant phenotype (Sano et al., 2005)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 11 terms )
Molecular Function
CV term Evidence References
phosphatidate phosphatase activity inferred from sequence or structural similarity (Hayden and Howard, 1999) non-traceable author statement (Morrison et al., 2000) non-traceable author statement (assigned by UniProtKB) (Swiss-Prot Project Members, 2002.6.15) protein homodimerization activity traceable author statement (Pyne et al., 2004)
Biological Process
CV term Evidence References
dephosphorylation non-traceable author statement (Morrison et al., 2000) non-traceable author statement (assigned by UniProtKB) (Swiss-Prot Project Members, 2002.6.15) embryonic pattern specification traceable author statement (Pyne et al., 2004) germ cell migration non-traceable author statement (Russell, 2001.7.18) non-traceable author statement (assigned by UniProtKB) (Zhang et al., 1997) traceable author statement (Wylie, 1999, Mueller, 2002) germ cell programmed cell death traceable author statement (Coffman, 2003) germ cell repulsion traceable author statement (Coffman, 2003, Ribeiro et al., 2003, Luquain et al., 2003, Raz, 2004) pole cell migration traceable author statement (Howard, 1998)
Cellular Component
CV term Evidence References
integral to membrane non-traceable author statement (assigned by UniProtKB) (Swiss-Prot Project Members, 2002.6.15) membrane inferred from electronic annotation with InterPro:IPR000326 (FlyBase Curators et al., 2004-) plasma membrane inferred from sequence or structural similarity (assigned by UniProtKB) (Zhang et al., 1997)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions wun allele Gene References wunCE wun2 (Hanyu-Nakamura et al., 2004) unspecified L (Singh et al., 2005) pbl (Gregory et al., 2007) rdgA (Garcia-Murillas et al., 2006)
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0016078 DroID - A comprehensive database of gene and protein interactions. • FBgn0016078 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35966
Orthologs
Genome-wide drosophilid orthologs	Dana\GF13080 Dere\GG10557 Dgri\GH21309 Dmoj\GI19743 Dper\GL16886 Dpse\GA21332 Dsec\GM20603 Dsim\GD10076 Dvir\GJ18026 Dwil\GK21745 Dyak\GE22302
Curated drosophilid orthologs	Dpse\GA21332
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL007322-PA Aedes aegypti (mosquito) AGAP012445-PA Anopheles gambiae (mosquito) XP_001942868.1 Acyrthosiphon pisum (pea aphid) 83499 Branchiostoma floridae (lancelet) XP_001895537.1 Brugia malayi (roundworm nematode) ENSBTAP00000044571 Bos taurus (bovine) CAL0002240 Candida albicans (a form of yeast) CN05136 Caenorhabditis brenneri (small nematode) CBP10866 Caenorhabditis briggsae (nematode) CE31953 Caenorhabditis elegans (worm) ENSCAFP00000010197 Canis familiaris (dog) JA11726 Caenorhabditis japonica (nematode) CPIJ000134 Culex pipens (mosquito) ENSCPOP00000008809 Cavia porcellus (guinea pig) RP27925 Caenorhabditis remanei (nematode) 97189 Capitella spl (polychaete worm) DEHA2F15884g Debaryomyces Hansenii (yeast) 197078 Daphnia pulex (daphnia) ENSDARP00000078333 Danio rerio (zebra fish) ENSECAP00000019952 Equus caballus (horse) XP_652582 Entamoeba histolytica (anaerobic protozoan) XP_654847 Entamoeba histolytica (anaerobic protozoan) XP_656687 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000021484 Gymnopilus aculeatus (mushroom) ENSGALP00000017568 Gallus gallus (chicken) 194939 Hypsipyla robusta (cedar shoot borer) ENSP00000380085 Homo sapiens (human) ISCW015634-PA Ixodes scapularis (deer tick) 117144 Lottia gigantea (owl limpet) ENSMODP00000024326 Monodelphis domestica (gray opossum) ENSMMUP00000002940 Macaca mulatta (rhesus monkey) ENSMUSP00000065719 Mus musculus (house mouse) 42019 Nematostella vectensis (starlet anemone) XP_001605457.1 Nasonia vitripennis (wasp) ENSOANP00000019078 Ornithorynchus anatinus (platypus) ENSORLP00000006882 Oryzias latipes (japanese killifish) PHUM005522-PA Pediculus humanus (human body louse) PP13503 Pristionchus pacificus (nematode) ENSPPYP00000001520 Pongo pygmaeus (orangutan) 74748 Phytophthora ramorum (sudden oak death pathogen) ENSPTRP00000028918 Pan troglodytes (chimpanzee) ENSRNOP00000011237 Rattus norvegicus (norway rat) Smp_171720 Schistosoma mansoni (trematode parasite) XP_001194379.1 Strongylocentrotus purpuratus (purple sea urchin) XP_781471.2 Strongylocentrotus purpuratus (purple sea urchin) 64077 Trichoplax adhaerens (metazoa) XP_971190.2 Tribolium castaneum (red flour beetle) Tc00.1047053503809.110 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511277.359 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511355.30 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000010355 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000041881 Takifugu rubripes (pufferfish Takifugu) 81704.m00033 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000024374 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB19000 NV16393 LH16928 ISCW015634 FBgn0239527 FBgn0223730 FBgn0205191 FBgn0181851 FBgn0175485 JGI_V11_319295 JGI_V11_319296 JGI_V11_319297 JGI_V11_197078 FBgn0081320 FBgn0154490 FBgn0142480 FBgn0128771 FBgn0102865 FBgn0090113 FBgn0087983 CPIJ012565 CPIJ000134 BGIBMGA003967 BGIBMGA003968 ACYPI005610 GB17815 AGAP012445 AAEL007322 PHUM389600 GLEAN_15891
Stocks & Reagents
Stocks Listed in FlyBase ( 25 )
Bloomington	6951 wunEMS23/CyO; ry506 6950 wunEMS4/CyO, amosRoi-1 6952 wunEMS41/CyO, amosRoi-1
Harvard	- PBac{PB}wunc01445 - PBac{RB}wune02143
Kyoto	104437 w*; P{GawB}wunNP3279 125136 w1118; P{RS5}wun5-HA-1200 125726 w1118; P{RS5}wun5-HA-2881
VDRC	v6446 w1118; P{GD1640}v6446/TM3 v6447 w1118; P{GD1640}v6447/TM3 v51090 w1118; P{GD15706}v51090/TM3 v51091 w1118; P{GD15706}v51091/TM3
	More stocks available...
Genomic Clones ( 2 )
	BACR14J24 BACR15P11 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 187 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH02203 RE70417
Other clones	DPiM_GH02203 MIP13371
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD23023 LD37528 LD41163 LP17554 LP18135 RE04203 RE23069 RE38964 RE56652 RE61554 RE69734 RE74632
Other clones	165976 184100 542568 CK01.146D.C8 EC31701 EC31765 EC051723 EC052206 EC054646 EC054650 EC055944 EK120544 EK288845 EN10855 FGM310D11 RP003013435 RP003019139 RP003020967 RP003033487 RP003034948 RP003035426 RP003043171 RP003049196 RP003052056 RP003053314 RP003053790 RP003062812 RP003075102 RP003075463 RP003075590 RP003081966 RP003084220 RP003090980 RP003093408 RP003104533 RP003120919 RP003122551 RP003126420 RP003129873 RP003131111 RP003131466 RP003134313 RP003136103 RP003137672 RP003138071 RP003139085 RP003142437 RP003143872 RP003143982 RP003149222 RP003156512 RP003162262 RP003164526 RP003169256 RP003170878 RP003177034 RP003178377 RP003179885 RP003180105 RP003183099 RP003183613 RP003187041 RP003188584 RP003193387 RP003194855 RP003199658 RP003201373 RP003203802 RP003204685 RP003205530 RP003206817 RP003210441 RP003211681 RP003212557 RP003215137 RP003216848 RP003218775 RP003219676 RP003222255 RP003225955 RP003242888 RP003245275 RP003253986 RP003254068 RP003254855 RP003256748 RP003268574 RP003269124 RP003272196 RP003272979 RP003278443 RP003281557 RP003282549 RP003284132 RP003293378 RP003293545 RP003297015 RP003297778 RP003301394 RP003314036 RP003318193 RP003319952 RP003320355 RP003335043 RP003337116 RP003338644 RP003347983 RP003350117 RP003354595 RP003364089 RP003369825 RP003379042 RP003380295 RP003380598 RP003381473 RP003402504 RP003406245 RP003409828 RP003420053 RP003421553 RP003426054 RP003445933 RP003451738 RP003455291 RP003460923 RP003464439 RP003468459 RP003475745 RP003479512 RP003492979 RP003495917 RP003497946 RP003500082 RP003502932 RP003511891 RP003512922 RP003518803 RP003533198 RP003534816 RP003541620 RP003543657 RP003564547 RP003564745 RP003567559 RP003567623 RP003571499 RP003571936 RP003579646 RP003582277 RP003587716 RP003587796 RP003591787 RP003594479 RP003596859 RP003601669 RP003608193 RP003608969 RP003623934 RP003625737 RP003625761 RP003629759 RP003632293 RP003634306 RP003646673 RP003651778 RP003653396 RP003654958 RP003662452 RP003667549 RP003679596 RP003680168
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0016078 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35966
Antibody Information
Other Information
Discoverer
Etymology
	wun is named after a marshal in Chinese heaven, who was banished to earth in the form of a pig for causing a nuisance. Still causing a nuisance on earth, he was adopted by a monk named Tang after being outwitted in combat by the monk's monkey, Wukong. He was given the name 'Wunen', and taken on a trek to India to fetch Buddhist bark. Despite threats of further beatings, Wunen persisted in wandering off to steal food and chase beautiful girls. It is this wandering aspect of his behavior that gives the name 'wunen' to the wun gene. (Zhang and Howard, 1997.2.24)
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: wun l(2)k16806 (Rabinow, 2004.12.29)
Additional comments	"l(2)03497" may correspond to "wun"; the P{PZ} insertion in the "l(2)0349703497" allele maps 164bp upstream of the 5' end of the CT4876 transcript of "wun". (Misra, 2000.8.25)
Other Comments
	wun2 functions in germ cells in the embryo, enabling them to perceive the wun/wun2-related signal from the soma. (Renault et al., 2004) wun and wun2 appear to act redundantly. (Starz-Gaiano et al., 2001) wun has two properties that allow it to use repulsion to guide the germ cells. wun can transform a permissive cellular environment into a repulsive one, and is expressed in the gut in a pattern that guides germ cells towards the mesoderm. Its sequence suggests that it is involved in lipid metabolism. (Zhang et al., 1997) The wun gene is involved in guiding germ cell migration. (Matthews, 1996.2.2) wun is required for guidance of germ cell migration in early development. Loss of wun function disrupts the orientation of motion causing germ cells to disperse even though their normal target is well formed. (Zhang et al., 1996)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057845 NM_165674 RefSeq (Proteins) • NP_477193 NP_724787 DDBJ / EMBL / GenBank • AAC47449 AAD38570 AAF58942 AAL34392 AAM71066 AAN71484 AC008341 AF145595 AI062852 AI401851 AQ025894 AQ026117 AQ073398 AQ073721 AY046533 BI486929 BT001729 CW848181 CZ471901 CZ473592 CZ473687 U73822 Z71084 Entrez Gene - A searchable database of RefSeq genes. • 35966 UniProtKB/Swiss-Prot • Q9V576
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Phosphatidic acid phosphatase type 2/haloperoxidase (IPR000326) Phosphatidic acid phosphatase/chloroperoxidase, N-terminal (IPR016118)
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0016078 DroID - A comprehensive database of gene and protein interactions. • FBgn0016078 DRSC - Results from RNAi screens. • FBgn0016078 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0016078 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8804-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0016078 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35966 InParanoid A subset of ortholog calls from InParanoid. • AAEL007322-PA Aedes aegypti (mosquito) AGAP012445-PA Anopheles gambiae (mosquito) XP_001942868.1 Acyrthosiphon pisum (pea aphid) 83499 Branchiostoma floridae (lancelet) XP_001895537.1 Brugia malayi (roundworm nematode) ENSBTAP00000044571 Bos taurus (bovine) CAL0002240 Candida albicans (a form of yeast) CN05136 Caenorhabditis brenneri (small nematode) CBP10866 Caenorhabditis briggsae (nematode) CE31953 Caenorhabditis elegans (worm) ENSCAFP00000010197 Canis familiaris (dog) JA11726 Caenorhabditis japonica (nematode) CPIJ000134 Culex pipens (mosquito) ENSCPOP00000008809 Cavia porcellus (guinea pig) RP27925 Caenorhabditis remanei (nematode) 97189 Capitella spl (polychaete worm) DEHA2F15884g Debaryomyces Hansenii (yeast) 197078 Daphnia pulex (daphnia) ENSDARP00000078333 Danio rerio (zebra fish) ENSECAP00000019952 Equus caballus (horse) XP_652582 Entamoeba histolytica (anaerobic protozoan) XP_654847 Entamoeba histolytica (anaerobic protozoan) XP_656687 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000021484 Gymnopilus aculeatus (mushroom) ENSGALP00000017568 Gallus gallus (chicken) 194939 Hypsipyla robusta (cedar shoot borer) ENSP00000380085 Homo sapiens (human) ISCW015634-PA Ixodes scapularis (deer tick) 117144 Lottia gigantea (owl limpet) ENSMODP00000024326 Monodelphis domestica (gray opossum) ENSMMUP00000002940 Macaca mulatta (rhesus monkey) ENSMUSP00000065719 Mus musculus (house mouse) 42019 Nematostella vectensis (starlet anemone) XP_001605457.1 Nasonia vitripennis (wasp) ENSOANP00000019078 Ornithorynchus anatinus (platypus) ENSORLP00000006882 Oryzias latipes (japanese killifish) PHUM005522-PA Pediculus humanus (human body louse) PP13503 Pristionchus pacificus (nematode) ENSPPYP00000001520 Pongo pygmaeus (orangutan) 74748 Phytophthora ramorum (sudden oak death pathogen) ENSPTRP00000028918 Pan troglodytes (chimpanzee) ENSRNOP00000011237 Rattus norvegicus (norway rat) Smp_171720 Schistosoma mansoni (trematode parasite) XP_001194379.1 Strongylocentrotus purpuratus (purple sea urchin) XP_781471.2 Strongylocentrotus purpuratus (purple sea urchin) 64077 Trichoplax adhaerens (metazoa) XP_971190.2 Tribolium castaneum (red flour beetle) Tc00.1047053503809.110 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511277.359 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511355.30 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000010355 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000041881 Takifugu rubripes (pufferfish Takifugu) 81704.m00033 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000024374 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /sturtevant/wunen1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35966 modMine - Data generated by the modENCODE project. • FBgn0016078 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB19000 NV16393 LH16928 ISCW015634 FBgn0239527 FBgn0223730 FBgn0205191 FBgn0181851 FBgn0175485 JGI_V11_319295 JGI_V11_319296 JGI_V11_319297 JGI_V11_197078 FBgn0081320 FBgn0154490 FBgn0142480 FBgn0128771 FBgn0102865 FBgn0090113 FBgn0087983 CPIJ012565 CPIJ000134 BGIBMGA003967 BGIBMGA003968 ACYPI005610 GB17815 AGAP012445 AAEL007322 PHUM389600 GLEAN_15891
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	CG8804 (Kraut et al., 2001, Kraut et al., 2001, Morrison et al., 2000, Ni et al., 2010.12.1) l(2)k16806 (Zhang et al., 1996, Kozopas, 2003.3, Spradling et al., 1999, ) LPP-like (Garcia-Murillas et al., 2006) wun (Xavier-Neto, 2005, Dionne et al., 2006, Makridou et al., 2003, Garcia-Murillas et al., 2006, Renault et al., 2004, Burnett and Howard, 2003, Garcia-Murillas et al., 2006, Renault et al., 2004, Sano et al., 2005, Montell, 2006, Renault and Lehmann, 2006, Arancio et al., 2010, Tao et al., 2007, Choksi et al., 2006, Kucherenko et al., 2008, Adryan et al., 2007, Xi et al., 2008, Renault et al., 2010) Wun (Cronin et al., 2009) Wunen (Hayden and Howard, 1997)
Name Synonym	wunen (Zhang, 1996.10.10, Howard and Zhang, 1997, Zhang et al., 1996, Matthews, 1996.2.2, Gregory et al., 2007, Garcia-Murillas et al., 2006, Foglietti et al., 2006, Renault et al., 2004, Garcia-Murillas et al., 2006, Montell, 2006, Renault and Lehmann, 2006, Tao et al., 2007, Wawersik et al., 2005, Renault et al., 2010) Wunen (Burnett and Howard, 2003, Sano et al., 2005)
Secondary FlyBase IDs
	FBgn0017369
References ( 98 )
Generate a list of	All references relating to this gene ( 98 )
List References by type	Research paper  ( 34 ) Supplementary material  ( 7 ) Review  ( 19 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 12 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 3 ) Conference report  ( 3 ) Computer file  ( 4 ) Protein sequence record  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 3 )
	Horn et al., 2011, Nat. Methods 8(4): 341--346 Mapping of signaling networks through synthetic genetic interaction analysis by RNAi. [FBrf0213352] Arancio et al., 2010, Genetics 185(1): 129--140 The nucleosome remodeling factor ISWI functionally interacts with an evolutionarily conserved network of cellular factors. [FBrf0213976] Renault et al., 2010, Development 137(11): 1815--1823 Lipid phosphate phosphatase activity regulates dispersal and bilateral sorting of embryonic germ cells in Drosophila. [FBrf0210764] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...