• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\fry

General Information
Symbol	Dmel\fry	Species	D. melanogaster
Name	furry	Annotation symbol	CG32045
Feature type	protein_coding_gene	FlyBase ID	FBgn0016081
Gene Model Status	Current	Stock availability	16 publicly available
Also Known As	l(3)02240
Genomic Location
Chromosome (arm)	3L	Recombination map	3-
Cytogenetic map	67C3-67C4	Sequence location	3L:9,624,934..9,672,203 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene furry is referred to in FlyBase by the symbol Dmel\fry (CG32045, FBgn0016081). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence for 11 unique biological process terms, many of which group under: cellular component organization or biogenesis; biological regulation; post-embryonic organ morphogenesis; system development; appendage development; sensory organ development; regulation of neurogenesis; instar larval or pupal morphogenesis; regulation of developmental process; neuron differentiation. 21 alleles are reported. The phenotypes of these alleles are annotated with: egg; ovary; head bristle; wing cell; arista; triple row. It has 6 annotated transcripts and 6 annotated polypeptides. Protein features are: Armadillo-like helical; Armadillo-type fold. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-06 and 18-24 hour embryonic stages, during early pupal stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult eye, adult hindgut. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult midgut, larval hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult ovary, adult male reproductive system, larval/adult carcass. Gene sequence location is 3L:9624934..9672203.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	References Matsubara et al., 2011, Genes Dev. 25(18): 1982--1996 Controlled Vocabulary Terms day 6 of adulthood dendrite self-avoidance day 5 of adulthood male day 7 of adulthood spermatozoon
FB2012_01	Sequence features HFA08993 BKN21419 HFA10172 HFA10712 HFA10709
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 67C3-67C4   Limits computationally determined from genome sequence between P{EP}Hsp26EP3336&P{EP}Hsp26EP3315 and P{PZ}fry02240
Experimentally Determined Cytological Location
Cytogenetic map Notes References 67B-67D     (Cong, 2000.10.2) 67C4-67C5   (determined by in situ hybridisation)   (Spradling et al., 1999) 61-80     (Adler, 1996.4.28) 67C4-67C5     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	3- (Neufeld et al., 1998)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\fry for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) fry-RB FBtr0076417  NM_168357   10872   3479 fry-RC FBtr0301435  NM_168356   11016   3527 fry-RD FBtr0110843  NM_001043133   10789   1629 fry-RE FBtr0306240     11408   3533 fry-RF FBtr0306241     10905   3490 fry-RG FBtr0306242     11067   3544
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein fry-PB   FBpp0076146   384.3   3479   6.47     NP_729520   AAF50228 fry-PC   FBpp0290650   389.7   3527   6.49     NP_729519   AAF50234 fry-PD   FBpp0110140   180.4   1629   7.40     NP_001036598   ABI31247 fry-PE   FBpp0297350   390.6   3533   6.62       fry-PF   FBpp0297351   385.5   3490   6.45       fry-PG   FBpp0297352   391.4   3544   6.51
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Armadillo-type fold (IPR016024) Armadillo-like helical (IPR011989)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF50228   AE014296 AAF50234   AE014296 ABI31247   AF310159 AAG41424   AF351187 AAK37558   AI543616   AW944637   AY069860 AAL40005   AY231702   BF485747   BF488453   BF489075   BF492168   BF501024   BI638306   BI638880   BI641169   BT082069   BT099721   BT120177   BT126015   CK136020   CK658662   CO186583   CO186618   CO297652   CO300878   CO314663   CO320834   CO326548   CO326670   CO330928   CO343863   CZ484332   EC073956   EC080250   EC200160   EC206312   EC223136   EC234212   EC248646   EC250850   EC253102   EC254425   EC257418   EL884295   EL884426   EL884664   G00700
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VT28 E2QCY4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0016081    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0016081 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-06 and 18-24 hour embryonic stages, during early pupal stages, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0016081 expression level Developmental Stage   Expression Level embryo 00-02hr    1046 embryo 02-04hr    1419 embryo 04-06hr    944 embryo 06-08hr    967 embryo 08-10hr    983 embryo 10-12hr    693 embryo 12-14hr    1032 embryo 14-16hr    1176 embryo 16-18hr    1162 embryo 18-20hr    971 embryo 20-22hr    1435 embryo 22-24hr    1503 larva L1    653 larva L2    513 larva L3 12hr old    612 larva L3 puffstage 1-2    615 larva L3 puffstage 3-6    1086 larva L3 puffstage 7-9    963 white prepupae new    1954 white prepupae 12hr    1271 white prepupae 24hr    1469 pupae 2d postWPP    1058 pupae 3d postWPP    834 pupae 4d postWPP    1092 adult male 01day    1824 adult male 05day    2083 adult male 30day    2129 adult female 01day    1018 adult female 05day    820 adult female 30day    818 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1046) embryo 02-04hr  (1419) embryo 04-06hr  (944) embryo 06-08hr  (967) embryo 08-10hr  (983) embryo 10-12hr  (693) embryo 12-14hr  (1032) embryo 14-16hr  (1176) embryo 16-18hr  (1162) embryo 18-20hr  (971) embryo 20-22hr  (1435) embryo 22-24hr  (1503) larva L1  (653) larva L2  (513) larva L3 12hr old  (612) larva L3 puffstage 1-2  (615) larva L3 puffstage 3-6  (1086) larva L3 puffstage 7-9  (963) white prepupae new  (1954) white prepupae 12hr  (1271) white prepupae 24hr  (1469) pupae 2d postWPP  (1058) pupae 3d postWPP  (834) pupae 4d postWPP  (1092) adult male 01day  (1824) adult male 05day  (2083) adult male 30day  (2129) adult female 01day  (1018) adult female 05day  (820) adult female 30day  (818) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1046 embryo 02-04hr  1419 embryo 04-06hr    944 embryo 06-08hr    967 embryo 08-10hr    983 embryo 10-12hr    693 embryo 12-14hr    1032 embryo 14-16hr    1176 embryo 16-18hr    1162 embryo 18-20hr    971 embryo 20-22hr  1435 embryo 22-24hr  1503 larva L1    653 larva L2    513 larva L3 12hr old    612 larva L3 puffstage 1-2    615 larva L3 puffstage 3-6    1086 larva L3 puffstage 7-9    963 white prepupae new  (1954) white prepupae 12hr    1271 white prepupae 24hr  1469 pupae 2d postWPP    1058 pupae 3d postWPP    834 pupae 4d postWPP    1092 adult male 01day  (1824) adult male 05day  (2083) adult male 30day  (2129) adult female 01day    1018 adult female 05day    820 adult female 30day    818 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1046 embryo 02-04hr    1419 embryo 04-06hr    944 embryo 06-08hr    967 embryo 08-10hr    983 embryo 10-12hr    693 embryo 12-14hr    1032 embryo 14-16hr    1176 embryo 16-18hr    1162 embryo 18-20hr    971 embryo 20-22hr    1435 embryo 22-24hr    1503 larva L1    653 larva L2    513 larva L3 12hr old    612 larva L3 puffstage 1-2    615 larva L3 puffstage 3-6    1086 larva L3 puffstage 7-9    963 white prepupae new    1954 white prepupae 12hr    1271 white prepupae 24hr    1469 pupae 2d postWPP    1058 pupae 3d postWPP    834 pupae 4d postWPP    1092 adult male 01day    1824 adult male 05day    2083 adult male 30day    2129 adult female 01day    1018 adult female 05day    820 adult female 30day    818 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1046 embryo 02-04hr    1419 embryo 04-06hr    944 embryo 06-08hr    967 embryo 08-10hr    983 embryo 10-12hr    693 embryo 12-14hr    1032 embryo 14-16hr    1176 embryo 16-18hr    1162 embryo 18-20hr    971 embryo 20-22hr    1435 embryo 22-24hr    1503 larva L1    653 larva L2    513 larva L3 12hr old    612 larva L3 puffstage 1-2    615 larva L3 puffstage 3-6    1086 larva L3 puffstage 7-9    963 white prepupae new    1954 white prepupae 12hr    1271 white prepupae 24hr    1469 pupae 2d postWPP    1058 pupae 3d postWPP    834 pupae 4d postWPP    1092 adult male 01day    1824 adult male 05day    2083 adult male 30day    2129 adult female 01day    1018 adult female 05day    820 adult female 30day    818 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0016081 expression level Developmental Stage   Expression Level embryo 00-02hr    1046 embryo 02-04hr    1419 embryo 04-06hr    944 embryo 06-08hr    967 embryo 08-10hr    983 embryo 10-12hr    693 embryo 12-14hr    1032 embryo 14-16hr    1176 embryo 16-18hr    1162 embryo 18-20hr    971 embryo 20-22hr    1435 embryo 22-24hr    1503 larva L1    653 larva L2    513 larva L3 12hr old    612 larva L3 puffstage 1-2    615 larva L3 puffstage 3-6    1086 larva L3 puffstage 7-9    963 white prepupae new    1954 white prepupae 12hr    1271 white prepupae 24hr    1469 pupae 2d postWPP    1058 pupae 3d postWPP    834 pupae 4d postWPP    1092 adult male 01day    1824 adult male 05day    2083 adult male 30day    2129 adult female 01day    1018 adult female 05day    820 adult female 30day    818 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1046) embryo 02-04hr  (1419) embryo 04-06hr  (944) embryo 06-08hr  (967) embryo 08-10hr  (983) embryo 10-12hr  (693) embryo 12-14hr  (1032) embryo 14-16hr  (1176) embryo 16-18hr  (1162) embryo 18-20hr  (971) embryo 20-22hr  (1435) embryo 22-24hr  (1503) larva L1  (653) larva L2  (513) larva L3 12hr old  (612) larva L3 puffstage 1-2  (615) larva L3 puffstage 3-6  (1086) larva L3 puffstage 7-9  (963) white prepupae new  (1954) white prepupae 12hr  (1271) white prepupae 24hr  (1469) pupae 2d postWPP  (1058) pupae 3d postWPP  (834) pupae 4d postWPP  (1092) adult male 01day  (1824) adult male 05day  (2083) adult male 30day  (2129) adult female 01day  (1018) adult female 05day  (820) adult female 30day  (818) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1046 embryo 02-04hr  1419 embryo 04-06hr    944 embryo 06-08hr    967 embryo 08-10hr    983 embryo 10-12hr    693 embryo 12-14hr    1032 embryo 14-16hr    1176 embryo 16-18hr    1162 embryo 18-20hr    971 embryo 20-22hr  1435 embryo 22-24hr  1503 larva L1    653 larva L2    513 larva L3 12hr old    612 larva L3 puffstage 1-2    615 larva L3 puffstage 3-6    1086 larva L3 puffstage 7-9    963 white prepupae new  1954 white prepupae 12hr    1271 white prepupae 24hr  1469 pupae 2d postWPP    1058 pupae 3d postWPP    834 pupae 4d postWPP    1092 adult male 01day  1824 adult male 05day  2083 adult male 30day  2129 adult female 01day    1018 adult female 05day    820 adult female 30day    818 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1046 embryo 02-04hr    1419 embryo 04-06hr    944 embryo 06-08hr    967 embryo 08-10hr    983 embryo 10-12hr    693 embryo 12-14hr    1032 embryo 14-16hr    1176 embryo 16-18hr    1162 embryo 18-20hr    971 embryo 20-22hr    1435 embryo 22-24hr    1503 larva L1    653 larva L2    513 larva L3 12hr old    612 larva L3 puffstage 1-2    615 larva L3 puffstage 3-6    1086 larva L3 puffstage 7-9    963 white prepupae new    1954 white prepupae 12hr    1271 white prepupae 24hr    1469 pupae 2d postWPP    1058 pupae 3d postWPP    834 pupae 4d postWPP    1092 adult male 01day    1824 adult male 05day    2083 adult male 30day    2129 adult female 01day    1018 adult female 05day    820 adult female 30day    818 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1046 embryo 02-04hr    1419 embryo 04-06hr    944 embryo 06-08hr    967 embryo 08-10hr    983 embryo 10-12hr    693 embryo 12-14hr    1032 embryo 14-16hr    1176 embryo 16-18hr    1162 embryo 18-20hr    971 embryo 20-22hr    1435 embryo 22-24hr    1503 larva L1    653 larva L2    513 larva L3 12hr old    612 larva L3 puffstage 1-2    615 larva L3 puffstage 3-6    1086 larva L3 puffstage 7-9    963 white prepupae new    1954 white prepupae 12hr    1271 white prepupae 24hr    1469 pupae 2d postWPP    1058 pupae 3d postWPP    834 pupae 4d postWPP    1092 adult male 01day    1824 adult male 05day    2083 adult male 30day    2129 adult female 01day    1018 adult female 05day    820 adult female 30day    818 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0016081    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0016081 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult eye, adult hindgut. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult midgut, larval hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult ovary, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_24
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0016081 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG32045-RB;CG32045-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4pnr-MD237 fryGD10439 lethal | larval stage | recessive fry1 fry2 fry4 lethal | recessive fry02240 viable fryPL00631 viable | poor fry7 Sterility Allele fertile fryPL00631 sterile, with Scer\GAL4Act.PU, fry1, fry2 fryScer\UAS.T:Hsap\MYC.T:Avic\GFP sterile, with Scer\GAL4Act.PU, fry1, fryScer\UAS.T:Hsap\MYC.T:Avic\GFP fry2 sterile, with Scer\GAL4Act.PU, fry1/fryScer\UAS.T:Hsap\MYC.T:Avic\GFP fry2 sterile, with Scer\GAL4Act.PU, fry2, fryScer\UAS.T:Hsap\MYC.T:Avic\GFP fry1 sterile, with Scer\GAL4Act.PU, fry2/fryScer\UAS.T:Hsap\MYC.T:Avic\GFP fry1 sterile (with fry1), with Scer\GAL4Act.PU, fry2 fryScer\UAS.T:Hsap\MYC.T:Avic\GFP sterile (with fry2), with Scer\GAL4Act.PU, fry1 fryScer\UAS.T:Hsap\MYC.T:Avic\GFP sterile (with fryScer\UAS.T:Hsap\MYC.T:Avic\GFP), with Scer\GAL4Act.PU, fry1 fry2 sterile (with fryScer\UAS.T:Hsap\MYC.T:Avic\GFP), with Scer\GAL4Act.PU, fry2 fry1 Other Phenotypes Allele visible fry02240 visible (with fry7) fry02240 visible (with fry02240) fry7 visible | cell autonomous | recessive | somatic clone fry2 visible | recessive | somatic clone fry1 Phenotype manifest in Allele adult abdomen & chaeta fry02240 arista fry02240 fry7 arista (with fry7) fry02240 arista (with fry02240) fry7 dendrite | cell autonomous | somatic clone | supernumerary fry1 egg, with Scer\GAL4Act.PU, fry1, fry2 fryScer\UAS.T:Hsap\MYC.T:Avic\GFP egg, with Scer\GAL4Act.PU, fry1, fryScer\UAS.T:Hsap\MYC.T:Avic\GFP fry2 egg, with Scer\GAL4Act.PU, fry2, fryScer\UAS.T:Hsap\MYC.T:Avic\GFP fry1 egg, with Scer\GAL4Act.PU, fry2/fryScer\UAS.T:Hsap\MYC.T:Avic\GFP fry1 egg (with fry2), with Scer\GAL4Act.PU, fry1 fryScer\UAS.T:Hsap\MYC.T:Avic\GFP egg (with fryScer\UAS.T:Hsap\MYC.T:Avic\GFP), with Scer\GAL4Act.PU, fry1 fry2 head bristle fry02240 leg & chaeta fry02240 mesothoracic tergum & chaeta fry02240 multidendritic neuron & dendrite fry02240 fry1 multidendritic neuron & dendrite (with fry1) fry02240 multidendritic neuron & dendrite (with fry02240) fry1 multidendritic neuron & dendrite | somatic clone fry1 multidendritic neuron & dendrite | supernumerary fry02240 fry1 multidendritic neuron & dendrite | supernumerary (with fry1) fry02240 multidendritic neuron & dendrite | supernumerary (with fry02240) fry1 ovary, with Scer\GAL4Act.PU, fry1, fry2 fryScer\UAS.T:Hsap\MYC.T:Avic\GFP ovary, with Scer\GAL4Act.PU, fry1, fryScer\UAS.T:Hsap\MYC.T:Avic\GFP fry2 ovary, with Scer\GAL4Act.PU, fry2, fryScer\UAS.T:Hsap\MYC.T:Avic\GFP fry1 ovary, with Scer\GAL4Act.PU, fry2/fryScer\UAS.T:Hsap\MYC.T:Avic\GFP fry1 ovary (with fry2), with Scer\GAL4Act.PU, fry1 fryScer\UAS.T:Hsap\MYC.T:Avic\GFP ovary (with fryScer\UAS.T:Hsap\MYC.T:Avic\GFP), with Scer\GAL4Act.PU, fry1 fry2 photoreceptor cell & eye disc | somatic clone frys308 rhabdomere | somatic clone frys308 fryunspecified triple row fry02240 wing cell (with fry1) fry2 wing cell (with fry2) fry1 wing hair | cell autonomous | somatic clone | supernumerary fry2 wing hair | ectopic (with fry1) fry2 wing hair | ectopic (with fry2) fry1 wing hair | somatic clone | supernumerary fry1 wing hair | supernumerary fry02240
Classical Alleles ( 16 )
For All Classical Alleles Show
Allele of fry Class Mutagen Stocks Known lesion fry02240 hypomorphic allele - genetic evidence P-element activity 1 Yes fry1 ethyl methanesulfonate 1 Yes fry7 P-element activity 1 -- fryc04927 1 -- fryDG23312 P-element activity 1 -- fryf01845 piggyBac transposase 1 -- fryMB01915 1 -- fryMI01128 1 -- fryMI02265 1 -- fryPL00631 P-element activity 1 Yes frys308 ethyl methanesulfonate X ray 1 -- fry2 ethyl methanesulfonate 0 Yes fry4 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- fryEP326 0 Yes fryKY319 0 -- fryunspecified ethyl methanesulfonate X ray 0 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of fry Class Mutagen Stocks Known lesion fryGD10439 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes fry1637.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 1 Yes fryKK101368 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes fryScer\UAS.T:Hsap\MYC.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 1 Yes fryN.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)AC1 (Neufeld et al., 1998, Spradling et al., 1999, Cong et al., 2001, BDGP Project Members, 1994-1999) Df(3L)BSC118 (Andrade and Cook, 2005.7.22) Df(3L)BSC391 (Christensen et al., 2007.10.29) Df(3L)BSC669 (Christensen et al., 2008.12.28) Df(3L)Exel6114 (Ryder, 2004.4.26)
Not disrupted in	Df(3L)29A6 (Cong et al., 2001)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10439} NA P{KK101368} NA P{UAS-myc-fry} NA P{UAS-Myc-fry-GFP} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{PZ}fry02240 No miscellaneous insertions Mi{MIC}fryMI01128 NA Mi{MIC}fryMI02265 NA P{wHy}fryDG23312 NA PBac{PB}fryc04927 NA PBac{WH}fryf01845 NA insertion of mobile activating element P{EP}fryEP326 NA insertion of enhancer trap binary system Mi{ET1}fryMB01915 No P{GawB}fryKY319 No PBac{GAL4D,EYFP}fryPL00631 No
Gene Ontology: Function, Process & Cellular Component ( 15 unique terms )
Terms Based on Experimental Evidence ( 15 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with trc (He et al., 2005)
Biological Process
CV term Evidence References
antennal morphogenesis inferred from mutant phenotype (He and Adler, 2002) chaeta morphogenesis inferred from mutant phenotype (Cong et al., 2001) dendrite self-avoidance inferred from genetic interaction with stan (Matsubara et al., 2011) imaginal disc-derived wing hair organization inferred from genetic interaction with trc (He et al., 2005) imaginal disc-derived wing morphogenesis inferred from mutant phenotype (Cong et al., 2001) non-sensory hair organization inferred from mutant phenotype (Cong et al., 2001) oocyte morphogenesis inferred from direct assay (Fang et al., 2010) positive regulation of protein kinase activity inferred from mutant phenotype (assigned by UniProtKB) (Emoto et al., 2004) regulation of dendrite development inferred from mutant phenotype (assigned by UniProtKB) (Emoto et al., 2004) regulation of dendrite morphogenesis inferred from mutant phenotype (Emoto et al., 2004) rhabdomere development inferred from mutant phenotype (Neufeld et al., 1998) NOT Wnt receptor signaling pathway inferred from genetic interaction with mwh (Cong et al., 2001)
Cellular Component
CV term Evidence References
cell cortex inferred from direct assay (He et al., 2005) cytoplasm inferred from direct assay (He et al., 2005)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions fry allele Gene References fry1 mwh (Cong et al., 2001) frys308 sina (Neufeld et al., 1998) fryunspecified sina (Neufeld et al., 1998) unspecified trc (He et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64513 DroID - A comprehensive database of gene and protein interactions. • FBgn0016081 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39122
Orthologs
Genome-wide drosophilid orthologs	Dana\GF24650 Dere\GG14017 Dgri\GH15141 Dmoj\GI12078 Dpse\GA16635 Dsec\GM24851 Dvir\GJ13348 Dwil\GK17571 Dyak\fry
Curated drosophilid orthologs	Dpse\GA16635   Dyak\fry
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AGAP004892-PA Anopheles gambiae (mosquito) XP_001946152.1 Acyrthosiphon pisum (pea aphid) At5g15680.1 Arabidopsis thaliana (wall cress) 23083 Batrachochytrium dendrobatidis (chytrid fungus) 125592 Branchiostoma floridae (lancelet) XP_001891673.1 Brugia malayi (roundworm nematode) ENSBTAP00000000158 Bos taurus (bovine) CAL0000189 Candida albicans (a form of yeast) CN02125 Caenorhabditis brenneri (small nematode) CBP34667 Caenorhabditis briggsae (nematode) CE38067 Caenorhabditis elegans (worm) ENSCAFP00000002915 Canis familiaris (dog) CAGL0G08822g Candida glabrata (haploid yeast) JA11739 Caenorhabditis japonica (nematode) cn02452 Cryptococcus neoformans (yeast-like fungus) ENSCPOP00000003536 Cavia porcellus (guinea pig) 145230 Chlamidomonas reinhardtii (green alga) RP48458 Caenorhabditis remanei (nematode) 159787 Capitella spl (polychaete worm) DDB0233061 Dictyostelium discoideum (amoeba) DEHA2A09218g Debaryomyces Hansenii (yeast) 306656 Daphnia pulex (daphnia) ENSDARP00000044293 Danio rerio (zebra fish) ENSECAP00000012841 Equus caballus (horse) ENSGACP00000027170 Gymnopilus aculeatus (mushroom) ENSGALP00000027526 Gallus gallus (chicken) 109994 Hypsipyla robusta (cedar shoot borer) ENSP00000369607 Homo sapiens (human) ISCW008558-PA Ixodes scapularis (deer tick) KLLA0F04587g Kluyveromyces lactis (yeast) 105090 Lottia gigantea (owl limpet) 22972 Monocosta brevicollis (choanoflagellate) ENSMODP00000011815 Monodelphis domestica (gray opossum) ENSMUSP00000084454 Mus musculus (house mouse) 20288 Nematostella vectensis (starlet anemone) ENSOANP00000026856 Ornithorynchus anatinus (platypus) ENSORLP00000000301 Oryzias latipes (japanese killifish) LOC_Os02g58410.1 Oryza sativa (asian rice) PHUM010781-PA Pediculus humanus (human body louse) 85366 Physcomitrella patens (moss) ENSPPYP00000005992 Pongo pygmaeus (orangutan) 266000 Populus trichocarpa (black cottonwood) ENSPTRP00000009808 Pan troglodytes (chimpanzee) ENSRNOP00000045830 Rattus norvegicus (norway rat) 127901 Sorghum bicolor (sorghum) YIL129C Saccharomyces cerevisiae (budding yeast) Smp_141860 Schistosoma mansoni (trematode parasite) SPBP19A11.04c Schizosaccharomyces pombe (fission yeast) 56185 Trichoplax adhaerens (metazoa) XP_969290.1 Tribolium castaneum (red flour beetle) ENSTNIP00000012806 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000012315 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000009564 Xenopus tropicalis (frog) YALI0D24035g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV30316 LH21305 ISCW008558 FBgn0067969 FBgn0219570 FBgn0200573 FBgn0184630 FBgn0184628 FBgn0179713 JGI_V11_306656 JGI_V11_223280 JGI_V11_113271 FBgn0076650 FBgn0150460 FBgn0150459 FBgn0134835 FBgn0122616 FBgn0106279 FBgn0101643 CPIJ004196 CPIJ004192 CPIJ018761 BGIBMGA003890 ACYPI009902 ACYPI006741 GB19491 AGAP004892 AAEL004186 AAEL004166 PB19964 PHUM538510 PHUM538540 GLEAN_00108
Stocks & Reagents
Stocks Listed in FlyBase ( 16 )
Bloomington	32105 w*; P{UAS-myc-fry}2 32106 w*; P{UAS-Myc-fry-GFP}2 32104 w*; fry7/TM6C, Sb1 33183 y1 w*; Mi{MIC}fryMI02265 23378 y1 w67c23; Mi{ET1}fryMB01915 30718 w*; frys308/TM3, P{GMR-sina.N}3, Sb1 32103 w*; fry1 P{white-un1}70C P{neoFRT}80B/TM6C, Sb1
Harvard	- PBac{PB}fryc04927 - PBac{WH}fryf01845
VDRC	v103569 P{KK101368}VIE-260B v40309 w1118; P{GD10439}v40309 v40308 w1118; P{GD10439}v40308/TM3
	More stocks available...
Genomic Clones ( 3 )
	BACR02B01 BACR07E07 BACR12K04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 32 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT27402 SD10447
Other clones	IP15823 MIP06803 MIP15317
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT16216 AT19707 AT23737 AT24774 AT29057 LP15784 SD21280 SD24377
Other clones	50400 57582 193225 214307.31 214373.26 EK021332 EK021551 EK170259 EK179564 EK237403 EK288401 EK296450 EP04123 EP04423 EP18243 IP15623 IP15723 IP15923 SD20559
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0016081 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39122
Antibody Information
	polyclonal (Fang and Adler, 2010)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: fry CG14171 CG6774 CG6780 (Cong et al., 2001, FlyBase, 1996-)
Additional comments	Annotations CG14171, CG6774, CG6780 merged as CG32045 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) "l(3)02240" may be allelic to "l(3)rK145". (Spradling, 1999.12.9) Source for merge of fry CG14171 CG6774 CG6780 was sequence comparison (date:001223). (FlyBase, 1996-)
Other Comments
	Mutations in fry result in branched arista laterals, branched bristles and a strong multiple wing hair phenotype. (Cong et al., 2001) 2 "SS3-7" alleles of fry have been isolated in a screen for dominant modifiers of the sinaGMR.PN eye phenotype. (Neufeld et al., 1998) Identified in an adult mosaic screen as a mutation resulting in multiple wing hairs. (Adler et al., 1996) 'yeti' is a tentative name. (Adler, 1996.4.28)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_168356 NM_168357 NM_001043133 RefSeq (Proteins) • NP_729519 NP_729520 NP_001036598 DDBJ / EMBL / GenBank • AAF50228 AAF50234 AAG41424 AAK37558 AAL40005 ABI31247 AF310159 AF351187 AI543616 AW944637 AY069860 BI638306 CZ484332 G00700 Entrez Gene - A searchable database of RefSeq genes. • 39122 UniProtKB/TrEMBL • E2QCY4 Q9VT28
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Armadillo-type fold (IPR016024) Armadillo-like helical (IPR011989)
Linkouts
	BioGRID - A database of protein and genetic interactions • 64513 DroID - A comprehensive database of gene and protein interactions. • FBgn0016081 DRSC - Results from RNAi screens. • FBgn0016081 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0016081 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG32045-RB;CG32045-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0016081 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39122 InParanoid A subset of ortholog calls from InParanoid. • AGAP004892-PA Anopheles gambiae (mosquito) XP_001946152.1 Acyrthosiphon pisum (pea aphid) At5g15680.1 Arabidopsis thaliana (wall cress) 23083 Batrachochytrium dendrobatidis (chytrid fungus) 125592 Branchiostoma floridae (lancelet) XP_001891673.1 Brugia malayi (roundworm nematode) ENSBTAP00000000158 Bos taurus (bovine) CAL0000189 Candida albicans (a form of yeast) CN02125 Caenorhabditis brenneri (small nematode) CBP34667 Caenorhabditis briggsae (nematode) CE38067 Caenorhabditis elegans (worm) ENSCAFP00000002915 Canis familiaris (dog) CAGL0G08822g Candida glabrata (haploid yeast) JA11739 Caenorhabditis japonica (nematode) cn02452 Cryptococcus neoformans (yeast-like fungus) ENSCPOP00000003536 Cavia porcellus (guinea pig) 145230 Chlamidomonas reinhardtii (green alga) RP48458 Caenorhabditis remanei (nematode) 159787 Capitella spl (polychaete worm) DDB0233061 Dictyostelium discoideum (amoeba) DEHA2A09218g Debaryomyces Hansenii (yeast) 306656 Daphnia pulex (daphnia) ENSDARP00000044293 Danio rerio (zebra fish) ENSECAP00000012841 Equus caballus (horse) ENSGACP00000027170 Gymnopilus aculeatus (mushroom) ENSGALP00000027526 Gallus gallus (chicken) 109994 Hypsipyla robusta (cedar shoot borer) ENSP00000369607 Homo sapiens (human) ISCW008558-PA Ixodes scapularis (deer tick) KLLA0F04587g Kluyveromyces lactis (yeast) 105090 Lottia gigantea (owl limpet) 22972 Monocosta brevicollis (choanoflagellate) ENSMODP00000011815 Monodelphis domestica (gray opossum) ENSMUSP00000084454 Mus musculus (house mouse) 20288 Nematostella vectensis (starlet anemone) ENSOANP00000026856 Ornithorynchus anatinus (platypus) ENSORLP00000000301 Oryzias latipes (japanese killifish) LOC_Os02g58410.1 Oryza sativa (asian rice) PHUM010781-PA Pediculus humanus (human body louse) 85366 Physcomitrella patens (moss) ENSPPYP00000005992 Pongo pygmaeus (orangutan) 266000 Populus trichocarpa (black cottonwood) ENSPTRP00000009808 Pan troglodytes (chimpanzee) ENSRNOP00000045830 Rattus norvegicus (norway rat) 127901 Sorghum bicolor (sorghum) YIL129C Saccharomyces cerevisiae (budding yeast) Smp_141860 Schistosoma mansoni (trematode parasite) SPBP19A11.04c Schizosaccharomyces pombe (fission yeast) 56185 Trichoplax adhaerens (metazoa) XP_969290.1 Tribolium castaneum (red flour beetle) ENSTNIP00000012806 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000012315 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000009564 Xenopus tropicalis (frog) YALI0D24035g Yarrowia lipolytica (nonconventional yeast) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/furry.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39122 modMine - Data generated by the modENCODE project. • FBgn0016081 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV30316 LH21305 ISCW008558 FBgn0067969 FBgn0219570 FBgn0200573 FBgn0184630 FBgn0184628 FBgn0179713 JGI_V11_306656 JGI_V11_223280 JGI_V11_113271 FBgn0076650 FBgn0150460 FBgn0150459 FBgn0134835 FBgn0122616 FBgn0106279 FBgn0101643 CPIJ004196 CPIJ004192 CPIJ018761 BGIBMGA003890 ACYPI009902 ACYPI006741 GB19491 AGAP004892 AAEL004186 AAEL004166 PB19964 PHUM538510 PHUM538540 GLEAN_00108
Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym	CG6774   CG6780   CG14171   CG32045 (Keleman et al., 2009.8.5) fry (Fang and Adler, 2007, Zinn, 2004, Christensen et al., 2007.10.29, He et al., 2005, He et al., 2005, Emoto et al., 2006, Christensen et al., 2008.12.28, Parrish et al., 2007, Parrish et al., 2009, Fang and Adler, 2010, Wasbrough et al., 2010, Matsubara et al., 2011) Fry (He et al., 2005, Emoto et al., 2006, Fang et al., 2010) l(3)02240 (Spradling, 1999.12.9, Spradling et al., 1999, BDGP Project Members, 1994-1999, ) SS3-7 (Neufeld et al., 1998) yeti (Adler, 1996.4.28)
Name Synonym	furry (Adler et al., 1996, Zinn, 2004, He et al., 2005, Shah et al., 2008, Parrish et al., 2009, Fang et al., 2010) Furry (Emoto et al., 2006) Suppressor of GMR-sina 3-7 (Neufeld et al., 1998)
Secondary FlyBase IDs
	FBgn0010771 FBgn0036021 FBgn0036025 FBgn0036027 FBgn0052045
References ( 51 )
Generate a list of	All references relating to this gene ( 51 )
List References by type	Research paper  ( 16 ) Supplementary material  ( 3 ) Review  ( 3 ) Personal communication to FlyBase  ( 15 ) Abstract  ( 6 ) FlyBase analysis  ( 3 ) Computer file  ( 4 ) DNA/RNA sequence record  ( 1 )
Recent research papers ( 3 )
	Matsubara et al., 2011, Genes Dev. 25(18): 1982--1996 The seven-pass transmembrane cadherin Flamingo controls dendritic self-avoidance via its binding to a LIM domain protein, Espinas, in Drosophila sensory neurons. [FBrf0215818] Fang and Adler, 2010, Dev. Biol. 341(2): 360--374 Regulation of cell shape, wing hair initiation and the actin cytoskeleton by Trc/Fry and Wts/Mats complexes. [FBrf0210701] Fang et al., 2010, BMC Dev. Biol. 10: 40 The Drosophila Fry protein interacts with Trc and is highly mobile in vivo. [FBrf0210776] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...