FlyBase Gene Report: Dmel\fry

General Information

Symbol

Dmel\fry

Species

D. melanogaster

Name

furry

Annotation Symbol

CG32045

Feature Type

protein_coding_gene

FlyBase ID

FBgn0016081

Gene Model Status

Current

Stock Availability

20 publicly available

Gene Snapshot

furry (fry) encodes a large conserved protein that functions with the product of trc. Its mutations lead to mulitpled hairs, split and multipled arista laterals and to defects in dendritic tiling. [Date last reviewed: 2019-03-07]

Other Summaries

Alliance
Auto summary
UniProtKB
Interactive Fly

Also Known As

l(3)02240

Key Links

Genomic Location

Cytogenetic map

67C3-67C4

Sequence location

3L:9,631,834..9,679,103 [-]

Recombination map

3-31

RefSeq locus

NT_037436 REGION:9631834..9679103

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (25 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables protein binding

inferred from physical interaction with FLYBASE:trc; FB:FBgn0003744

(He et al., 2005)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (17 terms)

Terms Based on Experimental Evidence (15 terms)

CV Term

Evidence

References

involved_in antennal morphogenesis

inferred from mutant phenotype

(He and Adler, 2002)

involved_in chaeta morphogenesis

inferred from mutant phenotype

(Cong et al., 2001)

involved_in dendrite self-avoidance

inferred from genetic interaction with FLYBASE:stan; FB:FBgn0024836

(Matsubara et al., 2011)

involved_in imaginal disc-derived wing hair organization

inferred from genetic interaction with FLYBASE:trc; FB:FBgn0003744

(He et al., 2005)

involved_in imaginal disc-derived wing morphogenesis

inferred from mutant phenotype

(Cong et al., 2001)

involved_in microtubule sliding

inferred from mutant phenotype

(assigned by UniProt )

(Norkett et al., 2020)

involved_in negative regulation of neuron projection arborization

inferred from mutant phenotype

(assigned by UniProt )

(Norkett et al., 2020)

involved_in non-sensory hair organization

inferred from mutant phenotype

(Cong et al., 2001)

involved_in oocyte morphogenesis

inferred from direct assay

(Fang et al., 2010)

involved_in positive regulation of protein kinase activity

inferred from mutant phenotype

(assigned by UniProt )

(Emoto et al., 2004)

involved_in positive regulation of protein serine/threonine kinase activity

inferred from mutant phenotype

(assigned by UniProt )

(Norkett et al., 2020)

involved_in positive regulation of transcription, DNA-templated

inferred from mutant phenotype

(assigned by UniProt )

(Emoto et al., 2004)

involved_in regulation of dendrite development

inferred from mutant phenotype

(assigned by UniProt )

(Emoto et al., 2004)

involved_in regulation of dendrite morphogenesis

inferred from mutant phenotype

(Emoto et al., 2004)

involved_in rhabdomere development

inferred from mutant phenotype

(Neufeld et al., 1998)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in cell morphogenesis

inferred from biological aspect of ancestor with PANTHER:PTN000265604

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in neuron projection development

inferred from biological aspect of ancestor with PANTHER:PTN000958636

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (7 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

located_in apical part of cell

inferred from direct assay

(Horne-Badovinac et al., 2012)

located_in axon

inferred from direct assay

(Emoto et al., 2004)

located_in cell body

inferred from direct assay

(Emoto et al., 2004)

located_in cell cortex

inferred from direct assay

(He et al., 2005)

located_in cytoplasm

inferred from direct assay

(Horne-Badovinac et al., 2012, He et al., 2005)

located_in dendrite

inferred from direct assay

(Emoto et al., 2004)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in cell cortex

inferred from biological aspect of ancestor with PANTHER:PTN000265604

(assigned by GO_Central )

(Gaudet et al., 2011)

located_in site of polarized growth

inferred from biological aspect of ancestor with PANTHER:PTN000265604

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

Protein Family (UniProt)

Belongs to the furry protein family. (Q9VT28)

Protein Signatures (InterPro)

Summaries

Protein Function (UniProtKB)

Trc/fry signaling pathway plays a key role in maintaining the integrity of polarized cell extensions (arista) during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching. Fry positively regulates trc kinase activity.

(UniProt, Q9VT28)

Summary (Interactive Fly)

conserved protein that is required for Tricornered activity in control of wing hair and bristle morphology - controls dendritic branching and tiling in sensory neurons

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\fry for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Sequence Ontology: Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012, Graveley et al., 2011)

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

fry-RB

FBtr0076417

NM_168357

10872

3479

fry-RC

FBtr0301435

NM_168356

11016

3527

fry-RE

FBtr0306240

NM_001259770

11408

3533

fry-RF

FBtr0306241

NM_001259771

10905

3490

fry-RG

FBtr0306242

NM_001259772

11067

3544

fry-RH

FBtr0333858

NM_001274708

11231

3474

fry-RI

FBtr0333859

NM_001274709

11049

3538

fry-RJ

FBtr0333860

NM_001274710

10920

3495

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

fry-PB

FBpp0076146

384.3

3479

6.47

NP_729520

AAF50228

fry-PC

FBpp0290650

389.7

3527

6.49

NP_729519

AAF50234

fry-PE

FBpp0297350

390.6

3533

6.62

NP_001246699

AFH04370

fry-PF

FBpp0297351

385.5

3490

6.45

NP_001246700

AFH04371

fry-PG

FBpp0297352

391.4

3544

6.51

NP_001246701

AFH04372

fry-PH

FBpp0305991

384.1

3474

6.62

NP_001261637

AGB94332

fry-PI

FBpp0305992

390.9

3538

6.47

NP_001261638

AGB94333

fry-PJ

FBpp0305993

386.0

3495

6.49

NP_001261639

AGB94334

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\fry using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

fry_1
fry_2

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

oogenesis stage S6 -- S8 & adult stage | female

follicle cell | apical

(Horne-Badovinac et al., 2012)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 5 of adulthood & male -- day 7 of adulthood & male

spermatozoon

(Wasbrough et al., 2010)

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in apical part of cell

inferred from direct assay

(Horne-Badovinac et al., 2012)

located_in axon

inferred from direct assay

(Emoto et al., 2004)

located_in cell body

inferred from direct assay

(Emoto et al., 2004)

located_in cell cortex

inferred from direct assay

(He et al., 2005)

located_in cytoplasm

inferred from direct assay

(Horne-Badovinac et al., 2012, He et al., 2005)

located_in dendrite

inferred from direct assay

(Emoto et al., 2004)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\fry in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\fry

View exonic expression by tissue for Dmel\fry

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0016081

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG32045-RB;CG32045-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32045

Flygut - An atlas of the Drosophila adult midgut

FBgn0016081

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 27 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of fry

Transgenic constructs containing regulatory region of fry

Deletions and Duplications ( 8 )

Disrupted in

Df(3L)AC1

(Cong et al., 2001, Spradling et al., 1999, Neufeld et al., 1998, BDGP Project Members, 1994-1999)

Df(3L)BSC118

(Andrade and Cook, 2005.7.22)

Df(3L)BSC391

(Christensen et al., 2007.10.29)

Df(3L)BSC669

(Christensen et al., 2008.12.28)

Df(3L)Exel6114

(Ryder, 2004.4.26)

Not disrupted in

Df(3L)29A6

(Cong et al., 2001)

Partially disrupted in

Df(3L)55

(Venkei and Szabad, 2005)

Df(3L)CNMaR^attP

(Rao and Deng, 2019.10.23)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^pnr-MD237

fry^GD10439

lethal (with Df(3L)BSC669)

fry^{MI12326-TG4.1}

lethal | recessive

fry⁰²²⁴⁰

lethal - all die before end of larval stage | recessive

partially lethal

fry⁷

viable

Sterility

Allele

fertile

fry^PL00631

sterile, with Scer\GAL4^Act.PU, fry¹, fry²

fry^{UAS.Tag:MYC.GFP}

sterile, with Scer\GAL4^Act.PU, fry¹, fry^{UAS.Tag:MYC.GFP}

fry²

sterile, with Scer\GAL4^Act.PU, fry¹/fry^{UAS.Tag:MYC.GFP}

fry²

sterile, with Scer\GAL4^Act.PU, fry², fry^{UAS.Tag:MYC.GFP}

fry¹

sterile, with Scer\GAL4^Act.PU, fry²/fry^{UAS.Tag:MYC.GFP}

fry¹

sterile (with fry¹), with Scer\GAL4^Act.PU, fry²

fry^{UAS.Tag:MYC.GFP}

sterile (with fry²), with Scer\GAL4^Act.PU, fry¹

fry^{UAS.Tag:MYC.GFP}

sterile (with fry^{UAS.Tag:MYC.GFP}), with Scer\GAL4^Act.PU, fry¹

fry²

sterile (with fry^{UAS.Tag:MYC.GFP}), with Scer\GAL4^Act.PU, fry²

fry¹

Other Phenotypes

Allele

neuroanatomy defective | third instar larval stage (with fry¹)

fry⁰²²⁴⁰

neuroanatomy defective | third instar larval stage (with fry⁰²²⁴⁰)

fry¹

some die during larval stage | recessive

visible

fry⁰²²⁴⁰

visible (with fry⁷)

fry⁰²²⁴⁰

visible (with fry⁰²²⁴⁰)

fry⁷

visible | cell autonomous | recessive | somatic clone

fry²

visible | recessive | somatic clone

fry¹

Phenotype manifest in

Allele

actin filament | somatic clone

fry^O31

adult abdomen & chaeta

fry⁰²²⁴⁰

arista

arista (with fry⁷)

fry⁰²²⁴⁰

arista (with fry⁰²²⁴⁰)

fry⁷

dendrite | cell autonomous | somatic clone | supernumerary

fry¹

egg, with Scer\GAL4^Act.PU, fry¹, fry²

fry^{UAS.Tag:MYC.GFP}

egg, with Scer\GAL4^Act.PU, fry¹, fry^{UAS.Tag:MYC.GFP}

fry²

egg, with Scer\GAL4^Act.PU, fry², fry^{UAS.Tag:MYC.GFP}

fry¹

egg, with Scer\GAL4^Act.PU, fry²/fry^{UAS.Tag:MYC.GFP}

fry¹

egg (with fry²), with Scer\GAL4^Act.PU, fry¹

fry^{UAS.Tag:MYC.GFP}

egg (with fry^{UAS.Tag:MYC.GFP}), with Scer\GAL4^Act.PU, fry¹

fry²

egg | somatic clone

egg chamber | somatic clone

fry^O31

follicle cell | somatic clone

fry^O31

head bristle

fry⁰²²⁴⁰

larval dorsal multidendritic neuron ddaC | third instar larval stage (with fry¹)

fry⁰²²⁴⁰

larval dorsal multidendritic neuron ddaC | third instar larval stage (with fry⁰²²⁴⁰)

fry¹

leg & chaeta

fry⁰²²⁴⁰

mesothoracic tergum & chaeta

fry⁰²²⁴⁰

multidendritic neuron & dendrite

multidendritic neuron & dendrite (with fry¹)

fry⁰²²⁴⁰

multidendritic neuron & dendrite (with fry⁰²²⁴⁰)

fry¹

multidendritic neuron & dendrite | somatic clone

fry¹

multidendritic neuron & dendrite | supernumerary

multidendritic neuron & dendrite | supernumerary (with fry¹)

fry⁰²²⁴⁰

multidendritic neuron & dendrite | supernumerary (with fry⁰²²⁴⁰)

fry¹

ovary, with Scer\GAL4^Act.PU, fry¹, fry²

fry^{UAS.Tag:MYC.GFP}

ovary, with Scer\GAL4^Act.PU, fry¹, fry^{UAS.Tag:MYC.GFP}

fry²

ovary, with Scer\GAL4^Act.PU, fry², fry^{UAS.Tag:MYC.GFP}

fry¹

ovary, with Scer\GAL4^Act.PU, fry²/fry^{UAS.Tag:MYC.GFP}

fry¹

ovary (with fry²), with Scer\GAL4^Act.PU, fry¹

fry^{UAS.Tag:MYC.GFP}

ovary (with fry^{UAS.Tag:MYC.GFP}), with Scer\GAL4^Act.PU, fry¹

fry²

photoreceptor cell & eye disc | somatic clone

fry^s308

rhabdomere | somatic clone

triple row

fry⁰²²⁴⁰

wing cell (with fry¹)

fry²

wing cell (with fry²)

fry¹

wing hair | cell autonomous | somatic clone | supernumerary

fry²

wing hair | ectopic (with fry¹)

fry²

wing hair | ectopic (with fry²)

fry¹

wing hair | somatic clone | supernumerary

fry¹

wing hair | supernumerary

fry⁰²²⁴⁰

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (2)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\FRYL

14 of 15

Yes

Hsap\FRY

12 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (2)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Fryl

13 of 15

Yes

Mmus\Fry

10 of 15

Yes

Rattus norvegicus (Norway rat) (2)

Rnor\Fryl

9 of 13

Yes

Rnor\Fry

7 of 13

Yes

Xenopus tropicalis (Western clawed frog) (2)

Xtro\fryl

9 of 12

Yes

Xtro\fry

2 of 12

Yes

Danio rerio (Zebrafish) (3)

Drer\fryl

14 of 15

Yes

Drer\frya

8 of 15

Yes

Drer\fryb

8 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\sax-2

14 of 15

Yes

Arabidopsis thaliana (thale-cress) (1)

Atha\AT5G15680

6 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\TAO3

10 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\mor2

8 of 12

Yes

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919002R )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA16635

Drosophila persimilis

Dper\GL12854

Drosophila willistoni

Dwil\GK17571

Drosophila virilis

Dvir\GJ13348

Drosophila mojavensis

Dmoj\GI12078

Drosophila grimshawi

Dgri\GH15141

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500J3 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17009240

Musca domestica

House fly

Mdoa\17022102

Glossina morsitans

Tsetse fly

Gmor\GMOY012002

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_02672

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_07643

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_02677

Mayetiola destructor

Hessian fly

Mdes\Mdes004865

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL004186

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL004166

Anopheles darlingi

American malaria mosquito

Adar\ADAC010451

Anopheles darlingi

American malaria mosquito

Adar\ADAC010452

Anopheles gambiae

Malaria mosquito

Agam\AGAP004892

Anopheles gambiae

Malaria mosquito

Agam\AGAP012775

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ004198

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ004193

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ018761

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ004192

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ004196

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00EZ )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA003890

Danaus plexippus

Monarch butterfly

Dple\DPOGS203000-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL013533

Heliconius melpomene

Postman butterfly

Hmel\HMEL011016

Apis florea

Little honeybee

Aflo\2619434244

Apis mellifera

Western honey bee

Amel\GB42489

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP13675

Bombus terrestris

Buff-tailed bumblebee

Bter\15209505

Linepithema humile

Argentine ant

Lhum\LH21305

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:000f16

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG007296

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_09878

Tribolium castaneum

Red flour beetle

Tcas\TC000108

Pediculus humanus

Human body louse

Phum\PHUM538510

Pediculus humanus

Human body louse

Phum\PHUM538540

Rhodnius prolixus

Kissing bug

Rpro\RPRC007063

Rhodnius prolixus

Kissing bug

Rpro\RPRC007204

Cimex lectularius

Bed bug

Clec\CLEC000533

Cimex lectularius

Bed bug

Clec\CLEC000534

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI009902

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI006741

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_11609

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X00DZ )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR007051

Ixodes scapularis

Black-legged tick

Isca\ISCW008558

Stegodyphus mimosarum

African social velvet spider

Smim\KFM83448.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM83446.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM83447.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur06g05140

Tetranychus urticae

Two-spotted spider mite

Turt\tetur06g05000

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_113271

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_223280

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_306656

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G003A )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-FryhL

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-FryL_2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Fryh

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000022157

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000014937

Gallus gallus

Domestic chicken

Ggal\FRYL

Gallus gallus

Domestic chicken

Ggal\FRY

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (0)

No records found.

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 2 )

Allele

Disease

Interaction

References

fry⁰²²⁴⁰

ameliorates tauopathy

modeled by Hsap\MAPT^V337M.UAS

(Shulman and Feany, 2003)

fry^EP326

exacerbates tauopathy

modeled by Hsap\MAPT^V337M.UAS

(Shulman and Feany, 2003)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

FRYL; FRY like transcription coactivator

14 of 15

FRY; FRY microtubule binding protein

12 of 15

614818

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

fry - trc

anti tag coimmunoprecipitation, anti tag western blot, two hybrid

(Fang et al., 2010, He et al., 2005)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

fry

suppressible

mew|mys

(Han et al., 2012)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

sina

enhanceable

fry

(Neufeld et al., 1998)

sina

suppressible

fry

(Neufeld et al., 1998)

trc

enhanceable

fry

(He et al., 2005)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

64513

DroID - A comprehensive database of gene and protein interactions.

FBgn0016081

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

39122

MIST (genetic) - An integrated Molecular Interaction Database

MIST (protein-protein) - An integrated Molecular Interaction Database

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-31

Cytogenetic map

67C3-67C4

Sequence location

3L:9,631,834..9,679,103 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

67C3-67C4

Limits computationally determined from genome sequence between P{EP}Hsp26^EP3336&P{EP}Hsp26^EP3315 and P{PZ}fry⁰²²⁴⁰

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

67B-67D

(Cong, 2000.10.2)

67C4-67C5

(determined by in situ hybridisation)

(Spradling et al., 1999)

61-80

(Adler, 1996.4.28)

67C4-67C5

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

3-31

(FlyBase, 2016)

3-23.7

(Comeron et al., 2012)

(Neufeld et al., 1998)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (20)

Bloomington

32105

w^*; P{UAS-myc-fry}2

32106

w^*; P{UAS-Myc-fry-GFP}2

32104

w^*; fry⁷/TM6C, Sb¹

33183

y¹ w^*; Mi{MIC}fry^MI02265

23378

y¹ w^67c23; Mi{ET1}fry^MB01915

84486

w^*; Df(3L)CNMaR^attP TI{TI}CNMaR^attP

30718

w^*; fry^s308/TM3, P{GMR-sina.N}3, Sb¹

59769

y¹ w^*; Mi{PT-GFSTF.1}fry^{MI01128-GFSTF.1}

60180

y¹ w^*; Mi{PT-GFSTF.2}fry^{MI02265-GFSTF.2}

34150

y¹ w^*; Mi{MIC}fry^MI01128 CNMaR^MI01128

VDRC

v103569

P{KK101368}VIE-260B

v40309

w¹¹¹⁸; P{GD10439}v40309

More stocks available...

Genomic Clones (51)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (32)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0016081

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0016081

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

39122

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Fang and Adler, 2010)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: fry CG14171 CG6774 CG6780

(Cong et al., 2001, FlyBase, 1996-)

Additional comments

Annotations CG14171, CG6774, CG6780 merged as CG32045 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

"l(3)02240" may be allelic to "l(3)rK145".

(Spradling, 1999.12.9)

Source for merge of fry CG14171 CG6774 CG6780 was sequence comparison ( date:001223 ).

(FlyBase, 1996-)

Other Comments

Mutations in fry result in branched arista laterals, branched bristles and a strong multiple wing hair phenotype.

(Cong et al., 2001)

2 "SS3-7" alleles of fry have been isolated in a screen for dominant modifiers of the sina^GMR.PN eye phenotype.

(Neufeld et al., 1998)

Identified in an adult mosaic screen as a mutation resulting in multiple wing hairs.

(Adler et al., 1996)

'yeti' is a tentative name.

(Adler, 1996.4.28)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 70 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

39122

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VT28

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0016081

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

fry_1
fry_2

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32045

Flygut - An atlas of the Drosophila adult midgut

FBgn0016081

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

39122

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC000108

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG32045

modMine - A data warehouse for the modENCODE project

FBgn0016081

Linkouts

BioGRID - A database of protein and genetic interactions.

64513

DroID - A comprehensive database of gene and protein interactions.

FBgn0016081

DRSC - Results frm RNAi screens

FBgn0016081

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0016081

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG32045-RB;CG32045-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0016081

FlyMine - An integrated database for Drosophila genomics

FBgn0016081

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

39122

MIST (genetic) - An integrated Molecular Interaction Database

MIST (protein-protein) - An integrated Molecular Interaction Database

Synonyms and Secondary IDs (13)

Reported As

Symbol Synonym

CG14171

CG32045

(Hassan et al., 2018, Keleman et al., 2009.8.5, Perkins et al., 2009)

CG6774

CG6780

Fry

(Norkett et al., 2020, Copf, 2015, Puram and Bonni, 2013, Gates, 2012, Fang et al., 2010, Emoto et al., 2006, He et al., 2005)

RE-B

(Horne-Badovinac et al., 2012)

SS3-7

(Neufeld et al., 1998)

fry

(Jiang et al., 2019, Rao and Deng, 2019.10.23, Hassan et al., 2018, Lee et al., 2018, Croze et al., 2017, Kline et al., 2017, Transgenic RNAi Project members, 2017-, Yang and Veraksa, 2017, Fear et al., 2016, Gene Disruption Project members, 2016-, Meltzer et al., 2016, Gene Disruption Project members, 2015-, Lee et al., 2015, Ashwal-Fluss et al., 2014, Kwon et al., 2013, Terriente-Felix et al., 2013, Gates, 2012, Han et al., 2012, Horne-Badovinac et al., 2012, Remolina et al., 2012, Rodriguez et al., 2012, Matsubara et al., 2011, Fang and Adler, 2010, Wasbrough et al., 2010, Parrish et al., 2009, Christensen et al., 2008.12.28, Christensen et al., 2007.10.29, Fang and Adler, 2007, Link et al., 2007, Parrish et al., 2007, Emoto et al., 2006, He et al., 2005, He et al., 2005, Stanyon et al., 2004, Zinn, 2004)

l(3)02240

(Spradling, 1999.12.9, Spradling et al., 1999, BDGP Project Members, 1994-1999)

yeti

(Adler, 1996.4.28)

Name Synonyms

Furry

(Emoto et al., 2006)

Suppressor of GMR-sina 3-7

(Neufeld et al., 1998)

furry

(Coutinho-Budd et al., 2017, Gates, 2012, Horne-Badovinac et al., 2012, Fang et al., 2010, Parrish et al., 2009, Shah et al., 2008, Link et al., 2007, He et al., 2005, Venkei and Szabad, 2005, Zinn, 2004, Adler et al., 1996)

Secondary FlyBase IDs

FBgn0010771
FBgn0036021
FBgn0036025
FBgn0036027
FBgn0052045

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (97)

The following external sites may use different assemblies or annotations than FlyBase.

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