Gene Hsap\CDKN1A

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General Information

Symbol

Hsap\CDKN1A

Species

H. sapiens

Name

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

Annotation symbol

Feature type

engineered_foreign_gene

FlyBase ID

FBgn0016095

Gene Model Status

Not Applicable

Stock availability

3 publicly available

Also Known As

p21, p21^CIP1/WAF1

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

Sequence location

Summary Information

Automatically generated summary

See sections below for more information

The gene cyclin-dependent kinase inhibitor 1A (p21, Cip1) is referred to in FlyBase by the symbol Hsap\CDKN1A (FBgn0016095). It is a engineered_foreign_gene from Homo sapiens. Its molecular function is unknown. The biological processes in which it is involved are not known. 3 alleles are reported. The phenotypes of these alleles are annotated with: organ system; adult segment; thoracic segment; organ system subdivision; external compound sense organ; adult; sense organ; mesothoracic oblique muscle; ventral nerve cord primordium; imaginal precursor. It has no annotated transcripts. Gene has not been localized to the genome sequence.

Recent Updates

Description

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FB2013_03

FB2013_02

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Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Mapped Features

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization (GO Cellular Component)

CV term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

modENCODE Anatomy RNA-Seq

modENCODE Development RNA-Seq

modENCODE Cell Lines RNA-Seq

modENCODE Treatments RNA-Seq

Expression Clusters

External Data & Images

Linkouts

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

lethal, with Scer\GAL4^32B

Hsap\CDKN1A^Scer\UAS.cHa

lethal, with Scer\GAL4^34B

Hsap\CDKN1A^Scer\UAS.cHa

lethal, with Scer\GAL4^Act5C.PI

Hsap\CDKN1A^Scer\UAS.cHa

lethal, with Scer\GAL4^ap-md544

Hsap\CDKN1A^Scer\UAS.cHa

lethal, with Scer\GAL4^da.G32

Hsap\CDKN1A^Scer\UAS.cHa

lethal, with Scer\GAL4^Dll-md23

Hsap\CDKN1A^Scer\UAS.cHa

lethal, with Scer\GAL4^h-H10

Hsap\CDKN1A^Scer\UAS.cHa

lethal, with Scer\GAL4^how-24B

Hsap\CDKN1A^Scer\UAS.cHa

lethal, with Scer\GAL4^T80

Hsap\CDKN1A^Scer\UAS.cHa

lethal, with Scer\GAL4^tey-5053A

Hsap\CDKN1A^Scer\UAS.cHa

lethal, with Scer\GAL4^tsh-md621

Hsap\CDKN1A^Scer\UAS.cHa

lethal, with Scer\GAL4^αTub84B.PL

Hsap\CDKN1A^Scer\UAS.cHa

Other Phenotypes

Allele

decreased cell number, with Scer\GAL4^sca-537.4

Hsap\CDKN1A^Scer\UAS.cHa

increased cell death, with Scer\GAL4^en-e16E

Hsap\CDKN1A^Scer\UAS.cHa

neuroanatomy defective, with Scer\GAL4^sca-537.4

Hsap\CDKN1A^Scer\UAS.cHa

planar polarity defective, with Scer\GAL4^en-e16E

Hsap\CDKN1A^Scer\UAS.cHa

visible

visible, with Scer\GAL4^dpp.blk1

Hsap\CDKN1A^Scer\UAS.cHa

visible, with Scer\GAL4^en-e16E

Hsap\CDKN1A^Scer\UAS.cHa

visible, with Scer\GAL4^ey.PH

Hsap\CDKN1A^Scer\UAS.cHa

visible, with Scer\GAL4^GMR.PF

Hsap\CDKN1A^Scer\UAS.cHa

visible, with Scer\GAL4^sca-T3

Hsap\CDKN1A^Scer\UAS.cHa

Phenotype manifest in

Allele

adult muscle precursor cell, with Scer\GAL4¹¹⁵¹

Hsap\CDKN1A^Scer\UAS.cHa

anterior crossvein, with Scer\GAL4^dpp.blk1

Hsap\CDKN1A^Scer\UAS.cHa

embryonic/larval salivary gland, with Scer\GAL4^ptc-559.1

Hsap\CDKN1A^Scer\UAS.cHa

eye

Hsap\CDKN1A^GMR.PH

eye, with Scer\GAL4^ey.PH

Hsap\CDKN1A^Scer\UAS.cHa

eye, with Scer\GAL4^GMR.PF

Hsap\CDKN1A^Scer\UAS.cHa

eye disc

Hsap\CDKN1A^GMR.PH

eye disc, with Scer\GAL4^ey.PH

Hsap\CDKN1A^Scer\UAS.cHa

eye disc, with Scer\GAL4^GMR.PF

Hsap\CDKN1A^Scer\UAS.cHa

interommatidial bristle

Hsap\CDKN1A^GMR.PH

macrochaeta, with Scer\GAL4^sca-T3

Hsap\CDKN1A^Scer\UAS.cHa

mesothoracic dorsal oblique muscle 1, with Scer\GAL4¹¹⁵¹

Hsap\CDKN1A^Scer\UAS.cHa

mesothoracic dorsal oblique muscle 2, with Scer\GAL4¹¹⁵¹

Hsap\CDKN1A^Scer\UAS.cHa

mesothoracic dorsal oblique muscle 3, with Scer\GAL4¹¹⁵¹

Hsap\CDKN1A^Scer\UAS.cHa

neuroblast NB6-4 of thorax, with Scer\GAL4^sca-537.4

Hsap\CDKN1A^Scer\UAS.cHa

neuron & embryonic thorax, with Scer\GAL4^sca-537.4

Hsap\CDKN1A^Scer\UAS.cHa

ommatidium

Hsap\CDKN1A^GMR.PH

pigment cell

Hsap\CDKN1A^GMR.PH

wing, with Scer\GAL4^en-e16E

Hsap\CDKN1A^Scer\UAS.cHa

wing & cell, with Scer\GAL4^en-e16E

Hsap\CDKN1A^Scer\UAS.cHa

wing & trichome, with Scer\GAL4^en-e16E

Hsap\CDKN1A^Scer\UAS.cHa

wing cell, with Scer\GAL4^dpp.blk1

Hsap\CDKN1A^Scer\UAS.cHa

wing cell, with Scer\GAL4^en-e16E

Hsap\CDKN1A^Scer\UAS.cHa

wing vein L3, with Scer\GAL4^dpp.blk1

Hsap\CDKN1A^Scer\UAS.cHa

Classical Alleles ( 0 )

For All Classical Alleles Show

Allele of Hsap\CDKN1A	Class	Mutagen	Stocks	Known lesion

Alleles Carried on Transgenic Constructs ( 3 )

For All Alleles Carried on Transgenic Constructs Show

Allele of Hsap\CDKN1A	Mutagen	Stocks	Known lesion
Hsap\CDKN1A^GMR.Ex	in vitro construct - regulatory fusion	3	Yes
Hsap\CDKN1A^GMR.PH	in vitro construct - regulatory fusion	0	Yes
Hsap\CDKN1A^Scer\UAS.cHa	in vitro construct - regulatory fusion	0	Yes

Aneuploid Aberrations

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

Insertions

Type of insertions

Name

Expression data

Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )

Terms Based on Experimental Evidence ( 0 terms )

Terms Based on Predictions or Assertions ( 0 terms )

Sequence Ontology: Class of Gene

engineered_foreign_gene

Interactions & Pathways

Summary of Physical Interactions

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

Hsap\CDKN1A allele

Gene

References

External Data

Linkouts

Orthologs

OrthoDB Orthologs (0) - based on analysis using Dmel annotation version 5.41

OrthoDB Ortholog Groups

OrthoDB orthology group searches

(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)

Drosophila inclusive ortholog search

No orthologs identified

Dipteran inclusive ortholog search

No orthologs identified

Insect inclusive ortholog search

No orthologs identified

Arthropod inclusive ortholog search

No orthologs identified

Metazoa inclusive ortholog search

No orthologs identified

Ortholog(s) in Drosophila melanogaster (None identified)

No D. melanogaster orthologies identified

Human Orthologs (0)

Gene

OMIM

HGNC

AAA Orthologs (0) based on analysis using Dmel annotation version 4.3

No orthologs identified

Stocks & Reagents

Stocks Listed in FlyBase ( 3 )

Bloomington

8397

w¹¹¹⁸; ebi^CCS-8/CyO, P{GMR-p21.Ex}2

8398

w¹¹¹⁸; ebi^WKS-24/CyO, P{GMR-p21.Ex}2

8414

y¹ w¹¹¹⁸; P{GMR-p21.Ex}3/TM3, Sb¹ Ser¹

Genomic Clones ( 0 )

cDNA Clones ( 0 )

cDNA Clones, Fully Sequenced

BDGP DGC clones

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Linkouts

Antibody Information

Other Information

Discoverer

Etymology

Identification

Relationship to Other Genes

Source for database identity of

Source for database merge of

Additional comments

FlyBase curator comment: Name changed to reflect current HGNC name (19th Nov. 2012).

(FlyBase Curators, 1992-)

Other Comments

Cyclin-dependent kinase inhibitor.

(Karim and Rubin, 1998)

Expression of Hsap\CDKN1A has been used to block the second mitotic wave in the developing eye. Each cell type is still specified, hence cell fate determination is regulated independently of the division pattern of the precursor cells.

(de Nooij and Hariharan, 1995)

Tag or Foreign Gene Data