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Gene Dmel\Acer

General Information
Symbol	Dmel\Acer	Species	D. melanogaster
Name	Angiotensin-converting enzyme-related	Annotation symbol	CG10593
Feature type	protein_coding_gene	FlyBase ID	FBgn0016122
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map	2-
Cytogenetic map	29D4-29D4	Sequence location	2L:8,521,933..8,525,740 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Angiotensin-converting enzyme-related is referred to in FlyBase by the symbol Dmel\Acer (CG10593, FBgn0016122). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: peptidyl-dipeptidase activity. There is experimental evidence that it is involved in the biological process: heart development; positive regulation of circadian sleep/wake cycle, sleep; sleep. 7 alleles are reported. The phenotype of these alleles is annotated with: heart primordium. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Peptidase M2, peptidyl-dipeptidase A. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during late pupal stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult heart, larval/adult fat body, adult spermathecae, adult testis, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult thoracico-abdominal ganglion, adult crop, larval/adult hindgut, adult ovary, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1640031_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Acer. Gene sequence location is 2L:8521933..8525740.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 29D4-29D4   Limits computationally determined from genome sequence between P{lacW}l(2)k03706k03706&P{lacW}Acerk07704 and P{PZ}lmg03424
Experimentally Determined Cytological Location
Cytogenetic map Notes References 29D-29E     (Shirras, 1996.3.25) 29D1-29D2   (determined by in situ hybridisation)   (Spradling et al., 1999) 29D1-29D2     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	2- (Shirras, 1996.3.25)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Acer for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Acer-RA FBtr0079685  NM_057847   2342   630 Acer-RB FBtr0333416  NM_001273329   3198   630
Additional Transcript Data & Comments
Reported size (kB)	4.0, 3.1 (northern blot) (Taylor et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Acer-PA   FBpp0079297   73.1   630   6.32     NP_477195   AAF52693 Acer-PB   FBpp0305608   73.1   630   6.32     NP_001260258   AGB92794
Additional Polypeptide Data & Comments
Reported size (kDa)	630 (aa) (Taylor et al., 1996)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Peptidase M2, peptidyl-dipeptidase A (IPR001548) MEROPS - An information resource for peptidases and the proteins that inhibit them • M02.002
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141104   AA141855   AA539520   AA694939   AA698673   AA942373   AA949240   AA949506   AE014134 AAF52693   AC004728   AC008330   AE014134 AGB92794   AI063626   AI110072   AI113629   AI113678   AI114162   AI134435   AI238076   AI404438   AI405190   AI512502   AI517645   AI945433   AQ025842   AW942882   AY051750 AAK93174   BE976168   BE977579   BF485667   BF486535   BF487106   BF487689   BF487716   BF487788   BF487882   BF488373   BF488510   BF488700   BF489210   BF489586   BF489890   BF490016   BF491077   BF491175   BF491709   BF492693   BF492694   BF493005   BF495355   BF495906   BF496245   BF497841   BF498491   BF499171   BF500583   BF500595   BF501494   BF501724   BF501926   BF502084   BF502615   BF503290   BF503738   BF506153   BF506319   BF506525   BG633991   BG634091   BG634602   BG634920   BG635046   BG635813   BI165858   BI166647   BI167639   BI169942   BI170040   BI215443   BI216072   BI230739   BI231635   BI234811   BI239593   BI239633   BI241203   BI356393   BI356793   BI357109   BI361587   BI365158   BI367932   BI368013   BI371809   BI375667   BI481760   BI481952   BI483295   BI483515   BI484073   BI484237   BI484983   BI485842   BI486859   BI566546   BI569955   BI570902   BI571367   BI582720   BI589953   BI590430   BI606825   BI609178   BI609966   BI626960   BI631384   BI634570   BI635611   CO182076   CO187953   CO261842   CO262413   CO268467   CO289399   CO289506   CO289790   CO291054   CO302112   CO311884   CO322598   CO323464   CO333463   CO333691   CO341596   EC052920   EC053006   EC053942   EC053956   EC054953   EC057701   EC058778   EC059498   EC061517   EC070329   EC085730   EC086081   EC086760   EC195215   EC208211   EC211921   EC228718   EC236931   EC242683   EC246163   EC251255   EC254763   EL880291   EV599658   FE863564   FE863618   FE863704   FE863752   FE863876   FE863952   GH740332   GH741635   GH744569   GH745933   GH746347   GH746660   GH747377   GH761436   GH768241   GH768452   GH769036   X96913 CAA65632
UniProtKB/Swiss-Prot	Q9VLJ6
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) yolk nucleus   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   amnioserosa   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   amnioserosa   (Fisher et al., 2012) fat body primordium   (Fisher et al., 2012) Comment:reported as fat body specific anlage fat body/gonad primordium   (Fisher et al., 2012) visceral muscle primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   amnioserosa   (Fisher et al., 2012) apoptotic amnioserosa   (Fisher et al., 2012) embryonic stage 14 -- 15   embryonic/larval dorsal vessel   (Taylor et al., 1996) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage & larval stage & adult stage     (Taylor et al., 1996)
Additional Descriptive Data
	Acer transcripts are observed by in situ hybridization in presumptive heart cells during dorsal closure. (Taylor et al., 1996) Acer transcripts are detected in embryos, larvae, and adults on northern blots. (Taylor et al., 1996)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
extracellular region inferred from direct assay (assigned by UniProtKB) (Houard et al., 1998) extracellular space inferred from direct assay (Carhan et al., 2011)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult heart, larval/adult fat body, adult spermathecae, adult testis, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult thoracico-abdominal ganglion, adult crop, larval/adult hindgut, adult ovary, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    40.275 Larval Midgut    31.3 Larval Hindgut    419.6 Larval Malpighian Tubules    67.7 Larval Fat Body    586.9 Larval Salivary Gland    35.4 Larval Trachea    52.775 Larval Carcass    332.875 Adult Head    1282.2 Adult Eye    556.95 Adult Brain    96.8 Adult Thoracic-Abdominal Ganglion    112.4 Adult Crop    417.3 Adult Midgut    58.3 Adult Hindgut    309.1 Adult Malpighian Tubules    35.5 Adult Fat Body    2618.3 Adult Salivary Gland    17.6 Adult Heart    1453.25 Adult VirginFemale Spermatheca    1522.1 Adult InseminatedFemale Spermatheca    2104 Adult Ovary    431 Adult Testis    920.1 Adult Male Accessory Gland    77.5 Adult Carcass    1529.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    40.275 Larval Midgut    31.3 Larval Hindgut    419.6 Larval Malpighian Tubules    67.7 Larval Fat Body  (586.9) Larval Salivary Gland    35.4 Larval Trachea    52.775 Larval Carcass    332.875 Adult Head  (1282.2) Adult Eye  (556.95) Adult Brain    96.8 Adult Thoracic-Abdominal Ganglion    112.4 Adult Crop    417.3 Adult Midgut    58.3 Adult Hindgut    309.1 Adult Malpighian Tubules    35.5 Adult Fat Body  (2618.3) Adult Salivary Gland    17.6 Adult Heart  (1453.25) Adult VirginFemale Spermatheca  (1522.1) Adult InseminatedFemale Spermatheca  (2104) Adult Ovary    431 Adult Testis  (920.1) Adult Male Accessory Gland    77.5 Adult Carcass  (1529.6) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    40.275 Larval Midgut    31.3 Larval Hindgut    419.6 Larval Malpighian Tubules    67.7 Larval Fat Body    586.9 Larval Salivary Gland    35.4 Larval Trachea    52.775 Larval Carcass    332.875 Adult Head  (1282.2) Adult Eye    556.95 Adult Brain    96.8 Adult Thoracic-Abdominal Ganglion    112.4 Adult Crop    417.3 Adult Midgut    58.3 Adult Hindgut    309.1 Adult Malpighian Tubules    35.5 Adult Fat Body  (2618.3) Adult Salivary Gland    17.6 Adult Heart  (1453.25) Adult VirginFemale Spermatheca  (1522.1) Adult InseminatedFemale Spermatheca  (2104) Adult Ovary    431 Adult Testis    920.1 Adult Male Accessory Gland    77.5 Adult Carcass  (1529.6) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    40.275 Larval Midgut    31.3 Larval Hindgut    419.6 Larval Malpighian Tubules    67.7 Larval Fat Body    586.9 Larval Salivary Gland    35.4 Larval Trachea    52.775 Larval Carcass    332.875 Adult Head    1282.2 Adult Eye    556.95 Adult Brain    96.8 Adult Thoracic-Abdominal Ganglion    112.4 Adult Crop    417.3 Adult Midgut    58.3 Adult Hindgut    309.1 Adult Malpighian Tubules    35.5 Adult Fat Body    2618.3 Adult Salivary Gland    17.6 Adult Heart    1453.25 Adult VirginFemale Spermatheca    1522.1 Adult InseminatedFemale Spermatheca    2104 Adult Ovary    431 Adult Testis    920.1 Adult Male Accessory Gland    77.5 Adult Carcass    1529.6 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    40.275 Larval Midgut    31.3 Larval Hindgut    419.6 Larval Malpighian Tubules    67.7 Larval Fat Body    586.9 Larval Salivary Gland    35.4 Larval Trachea    52.775 Larval Carcass    332.875 Adult Head    1282.2 Adult Eye    556.95 Adult Brain    96.8 Adult Thoracic-Abdominal Ganglion    112.4 Adult Crop    417.3 Adult Midgut    58.3 Adult Hindgut    309.1 Adult Malpighian Tubules    35.5 Adult Fat Body    2618.3 Adult Salivary Gland    17.6 Adult Heart    1453.25 Adult VirginFemale Spermatheca    1522.1 Adult InseminatedFemale Spermatheca    2104 Adult Ovary    431 Adult Testis    920.1 Adult Male Accessory Gland    77.5 Adult Carcass    1529.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    40.275 Larval Midgut    31.3 Larval Hindgut    419.6 Larval Malpighian Tubules    67.7 Larval Fat Body  586.9 Larval Salivary Gland    35.4 Larval Trachea    52.775 Larval Carcass    332.875 Adult Head  (1282.2) Adult Eye  556.95 Adult Brain    96.8 Adult Thoracic-Abdominal Ganglion    112.4 Adult Crop    417.3 Adult Midgut    58.3 Adult Hindgut    309.1 Adult Malpighian Tubules    35.5 Adult Fat Body  (2618.3) Adult Salivary Gland    17.6 Adult Heart  (1453.25) Adult VirginFemale Spermatheca  (1522.1) Adult InseminatedFemale Spermatheca  (2104) Adult Ovary    431 Adult Testis  (920.1) Adult Male Accessory Gland    77.5 Adult Carcass  (1529.6) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    40.275 Larval Midgut    31.3 Larval Hindgut    419.6 Larval Malpighian Tubules    67.7 Larval Fat Body    586.9 Larval Salivary Gland    35.4 Larval Trachea    52.775 Larval Carcass    332.875 Adult Head  1282.2 Adult Eye    556.95 Adult Brain    96.8 Adult Thoracic-Abdominal Ganglion    112.4 Adult Crop    417.3 Adult Midgut    58.3 Adult Hindgut    309.1 Adult Malpighian Tubules    35.5 Adult Fat Body  (2618.3) Adult Salivary Gland    17.6 Adult Heart  1453.25 Adult VirginFemale Spermatheca  1522.1 Adult InseminatedFemale Spermatheca  (2104) Adult Ovary    431 Adult Testis    920.1 Adult Male Accessory Gland    77.5 Adult Carcass  1529.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    40.275 Larval Midgut    31.3 Larval Hindgut    419.6 Larval Malpighian Tubules    67.7 Larval Fat Body    586.9 Larval Salivary Gland    35.4 Larval Trachea    52.775 Larval Carcass    332.875 Adult Head    1282.2 Adult Eye    556.95 Adult Brain    96.8 Adult Thoracic-Abdominal Ganglion    112.4 Adult Crop    417.3 Adult Midgut    58.3 Adult Hindgut    309.1 Adult Malpighian Tubules    35.5 Adult Fat Body    2618.3 Adult Salivary Gland    17.6 Adult Heart    1453.25 Adult VirginFemale Spermatheca    1522.1 Adult InseminatedFemale Spermatheca    2104 Adult Ovary    431 Adult Testis    920.1 Adult Male Accessory Gland    77.5 Adult Carcass    1529.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1282.2   NA  Eye    556.95   NA  Brain    96.8   40.275  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    112.4   NA  Crop    417.3   no informative data  Midgut    58.3   419.6  Hindgut    309.1   67.7  Malpighian Tubules    no informative data   586.9  Fat Body    2618.3   no informative data  Salivary Gland    no informative data   NA  Heart    1453.25   52.775  Trachea    NA   NA  VirginFemale Spermatheca    1522.1   NA  InseminatedFemale Spermatheca    2104   NA  Ovary    431   NA  Testis    920.1   NA  Male Accessory Gland    77.5   332.875  Carcass    1529.6 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    5 central nervous system, pupae P8    11 head, virgin 1-day female    37 head, virgin 4-day female    39 head, virgin 20-day female    91 head, mated 1-day female    22 head, mated 4-day female    43 head, mated 20-day female    51 head, mated 1-day male    19 head, mated 4-day male    39 head, mated 20-day male    60 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    5 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    11 fat body, white prepupae    33 fat body, pupae P8    35 carcass, larvae L3 wandering    6 carcass, 1-day adult    18 carcass, 4-day adult    23 carcass, 20-day adult    34 ovary, virgin 4-day female    19 ovary, mated 4-day female    20 testis, mated 4-day male    81 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    5 central nervous system, pupae P8    11 head, virgin 1-day female  (37) head, virgin 4-day female  (39) head, virgin 20-day female  (91) head, mated 1-day female    22 head, mated 4-day female  (43) head, mated 20-day female  (51) head, mated 1-day male    19 head, mated 4-day male  (39) head, mated 20-day male  (60) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    5 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    11 fat body, white prepupae  (33) fat body, pupae P8  (35) carcass, larvae L3 wandering    6 carcass, 1-day adult    18 carcass, 4-day adult    23 carcass, 20-day adult  (34) ovary, virgin 4-day female    19 ovary, mated 4-day female    20 testis, mated 4-day male  (81) accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    5 central nervous system, pupae P8    11 head, virgin 1-day female    37 head, virgin 4-day female    39 head, virgin 20-day female    91 head, mated 1-day female    22 head, mated 4-day female    43 head, mated 20-day female    51 head, mated 1-day male    19 head, mated 4-day male    39 head, mated 20-day male    60 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    5 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    11 fat body, white prepupae    33 fat body, pupae P8    35 carcass, larvae L3 wandering    6 carcass, 1-day adult    18 carcass, 4-day adult    23 carcass, 20-day adult    34 ovary, virgin 4-day female    19 ovary, mated 4-day female    20 testis, mated 4-day male    81 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    5 central nervous system, pupae P8    11 head, virgin 1-day female    37 head, virgin 4-day female    39 head, virgin 20-day female    91 head, mated 1-day female    22 head, mated 4-day female    43 head, mated 20-day female    51 head, mated 1-day male    19 head, mated 4-day male    39 head, mated 20-day male    60 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    5 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    11 fat body, white prepupae    33 fat body, pupae P8    35 carcass, larvae L3 wandering    6 carcass, 1-day adult    18 carcass, 4-day adult    23 carcass, 20-day adult    34 ovary, virgin 4-day female    19 ovary, mated 4-day female    20 testis, mated 4-day male    81 accessory gland, mated 4-day male    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    5 central nervous system, pupae P8    11 head, virgin 1-day female    37 head, virgin 4-day female    39 head, virgin 20-day female    91 head, mated 1-day female    22 head, mated 4-day female    43 head, mated 20-day female    51 head, mated 1-day male    19 head, mated 4-day male    39 head, mated 20-day male    60 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    5 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    11 fat body, white prepupae    33 fat body, pupae P8    35 carcass, larvae L3 wandering    6 carcass, 1-day adult    18 carcass, 4-day adult    23 carcass, 20-day adult    34 ovary, virgin 4-day female    19 ovary, mated 4-day female    20 testis, mated 4-day male    81 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    5 central nervous system, pupae P8    11 head, virgin 1-day female  (37) head, virgin 4-day female  (39) head, virgin 20-day female  (91) head, mated 1-day female    22 head, mated 4-day female  (43) head, mated 20-day female  (51) head, mated 1-day male    19 head, mated 4-day male  (39) head, mated 20-day male  (60) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    5 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    11 fat body, white prepupae  (33) fat body, pupae P8  (35) carcass, larvae L3 wandering    6 carcass, 1-day adult    18 carcass, 4-day adult    23 carcass, 20-day adult  (34) ovary, virgin 4-day female    19 ovary, mated 4-day female    20 testis, mated 4-day male  (81) accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    5 central nervous system, pupae P8    11 head, virgin 1-day female    37 head, virgin 4-day female    39 head, virgin 20-day female    91 head, mated 1-day female    22 head, mated 4-day female    43 head, mated 20-day female    51 head, mated 1-day male    19 head, mated 4-day male    39 head, mated 20-day male    60 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    5 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    11 fat body, white prepupae    33 fat body, pupae P8    35 carcass, larvae L3 wandering    6 carcass, 1-day adult    18 carcass, 4-day adult    23 carcass, 20-day adult    34 ovary, virgin 4-day female    19 ovary, mated 4-day female    20 testis, mated 4-day male    81 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    5 central nervous system, pupae P8    11 head, virgin 1-day female    37 head, virgin 4-day female    39 head, virgin 20-day female    91 head, mated 1-day female    22 head, mated 4-day female    43 head, mated 20-day female    51 head, mated 1-day male    19 head, mated 4-day male    39 head, mated 20-day male    60 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    5 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    11 fat body, white prepupae    33 fat body, pupae P8    35 carcass, larvae L3 wandering    6 carcass, 1-day adult    18 carcass, 4-day adult    23 carcass, 20-day adult    34 ovary, virgin 4-day female    19 ovary, mated 4-day female    20 testis, mated 4-day male    81 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during late pupal stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    37 embryo 02-04hr    82 embryo 04-06hr    104 embryo 06-08hr    86 embryo 08-10hr    61 embryo 10-12hr    77 embryo 12-14hr    116 embryo 14-16hr    125 embryo 16-18hr    54 embryo 18-20hr    34 embryo 20-22hr    18 embryo 22-24hr    21 larva L1    26 larva L2    35 larva L3 12hr old    50 larva L3 puffstage 1-2    24 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    17 white prepupae new    33 white prepupae 12hr    23 white prepupae 24hr    40 pupae 2d postWPP    58 pupae 3d postWPP    52 pupae 4d postWPP    47 adult male 01day    72 adult male 05day    82 adult male 30day    76 adult female 01day    39 adult female 05day    60 adult female 30day    68 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (37) embryo 02-04hr  (82) embryo 04-06hr  (104) embryo 06-08hr  (86) embryo 08-10hr  (61) embryo 10-12hr  (77) embryo 12-14hr  (116) embryo 14-16hr  (125) embryo 16-18hr  (54) embryo 18-20hr  (34) embryo 20-22hr    18 embryo 22-24hr    21 larva L1  26 larva L2  (35) larva L3 12hr old  (50) larva L3 puffstage 1-2    24 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    17 white prepupae new  (33) white prepupae 12hr    23 white prepupae 24hr  (40) pupae 2d postWPP  (58) pupae 3d postWPP  (52) pupae 4d postWPP  (47) adult male 01day  (72) adult male 05day  (82) adult male 30day  (76) adult female 01day  (39) adult female 05day  (60) adult female 30day  (68) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    37 embryo 02-04hr    82 embryo 04-06hr  104 embryo 06-08hr    86 embryo 08-10hr    61 embryo 10-12hr    77 embryo 12-14hr  (116) embryo 14-16hr  (125) embryo 16-18hr    54 embryo 18-20hr    34 embryo 20-22hr    18 embryo 22-24hr    21 larva L1    26 larva L2    35 larva L3 12hr old    50 larva L3 puffstage 1-2    24 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    17 white prepupae new    33 white prepupae 12hr    23 white prepupae 24hr    40 pupae 2d postWPP    58 pupae 3d postWPP    52 pupae 4d postWPP    47 adult male 01day    72 adult male 05day    82 adult male 30day    76 adult female 01day    39 adult female 05day    60 adult female 30day    68 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    37 embryo 02-04hr    82 embryo 04-06hr    104 embryo 06-08hr    86 embryo 08-10hr    61 embryo 10-12hr    77 embryo 12-14hr    116 embryo 14-16hr    125 embryo 16-18hr    54 embryo 18-20hr    34 embryo 20-22hr    18 embryo 22-24hr    21 larva L1    26 larva L2    35 larva L3 12hr old    50 larva L3 puffstage 1-2    24 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    17 white prepupae new    33 white prepupae 12hr    23 white prepupae 24hr    40 pupae 2d postWPP    58 pupae 3d postWPP    52 pupae 4d postWPP    47 adult male 01day    72 adult male 05day    82 adult male 30day    76 adult female 01day    39 adult female 05day    60 adult female 30day    68 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    37 embryo 02-04hr    82 embryo 04-06hr    104 embryo 06-08hr    86 embryo 08-10hr    61 embryo 10-12hr    77 embryo 12-14hr    116 embryo 14-16hr    125 embryo 16-18hr    54 embryo 18-20hr    34 embryo 20-22hr    18 embryo 22-24hr    21 larva L1    26 larva L2    35 larva L3 12hr old    50 larva L3 puffstage 1-2    24 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    17 white prepupae new    33 white prepupae 12hr    23 white prepupae 24hr    40 pupae 2d postWPP    58 pupae 3d postWPP    52 pupae 4d postWPP    47 adult male 01day    72 adult male 05day    82 adult male 30day    76 adult female 01day    39 adult female 05day    60 adult female 30day    68 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (37) embryo 02-04hr  (82) embryo 04-06hr  (104) embryo 06-08hr  (86) embryo 08-10hr  (61) embryo 10-12hr  (77) embryo 12-14hr  (116) embryo 14-16hr  (125) embryo 16-18hr  (54) embryo 18-20hr  (34) embryo 20-22hr    18 embryo 22-24hr    21 larva L1  26 larva L2  (35) larva L3 12hr old  (50) larva L3 puffstage 1-2    24 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    17 white prepupae new  (33) white prepupae 12hr    23 white prepupae 24hr  (40) pupae 2d postWPP  (58) pupae 3d postWPP  (52) pupae 4d postWPP  (47) adult male 01day  (72) adult male 05day  (82) adult male 30day  (76) adult female 01day  (39) adult female 05day  (60) adult female 30day  (68) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    37 embryo 02-04hr    82 embryo 04-06hr  104 embryo 06-08hr    86 embryo 08-10hr    61 embryo 10-12hr    77 embryo 12-14hr  116 embryo 14-16hr  125 embryo 16-18hr    54 embryo 18-20hr    34 embryo 20-22hr    18 embryo 22-24hr    21 larva L1    26 larva L2    35 larva L3 12hr old    50 larva L3 puffstage 1-2    24 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    17 white prepupae new    33 white prepupae 12hr    23 white prepupae 24hr    40 pupae 2d postWPP    58 pupae 3d postWPP    52 pupae 4d postWPP    47 adult male 01day    72 adult male 05day    82 adult male 30day    76 adult female 01day    39 adult female 05day    60 adult female 30day    68 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    37 embryo 02-04hr    82 embryo 04-06hr    104 embryo 06-08hr    86 embryo 08-10hr    61 embryo 10-12hr    77 embryo 12-14hr    116 embryo 14-16hr    125 embryo 16-18hr    54 embryo 18-20hr    34 embryo 20-22hr    18 embryo 22-24hr    21 larva L1    26 larva L2    35 larva L3 12hr old    50 larva L3 puffstage 1-2    24 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    17 white prepupae new    33 white prepupae 12hr    23 white prepupae 24hr    40 pupae 2d postWPP    58 pupae 3d postWPP    52 pupae 4d postWPP    47 adult male 01day    72 adult male 05day    82 adult male 30day    76 adult female 01day    39 adult female 05day    60 adult female 30day    68 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4    2 embryonic 1182-4H    3 embryonic GM2    0 embryonic Kc167    1 embryonic S1    41 embryonic S3    5 leg disc CME L1    1 wing disc CME-W2    25 wing disc ML-DmD8    1 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    1 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    5 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4    2 embryonic 1182-4H    3 embryonic GM2    0 embryonic Kc167    1 embryonic S1  (41) embryonic S3    5 leg disc CME L1    1 wing disc CME-W2    25 wing disc ML-DmD8    1 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    1 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    5 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4    2 embryonic 1182-4H    3 embryonic GM2    0 embryonic Kc167    1 embryonic S1    41 embryonic S3    5 leg disc CME L1    1 wing disc CME-W2    25 wing disc ML-DmD8    1 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    1 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    5 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4    2 embryonic 1182-4H    3 embryonic GM2    0 embryonic Kc167    1 embryonic S1    41 embryonic S3    5 leg disc CME L1    1 wing disc CME-W2    25 wing disc ML-DmD8    1 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    1 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    5 ovary OSS    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4    2 embryonic 1182-4H    3 embryonic GM2    0 embryonic Kc167    1 embryonic S1    41 embryonic S3    5 leg disc CME L1    1 wing disc CME-W2    25 wing disc ML-DmD8    1 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    1 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    5 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4    2 embryonic 1182-4H    3 embryonic GM2    0 embryonic Kc167    1 embryonic S1  (41) embryonic S3    5 leg disc CME L1    1 wing disc CME-W2    25 wing disc ML-DmD8    1 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    1 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    5 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4    2 embryonic 1182-4H    3 embryonic GM2    0 embryonic Kc167    1 embryonic S1    41 embryonic S3    5 leg disc CME L1    1 wing disc CME-W2    25 wing disc ML-DmD8    1 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    1 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    5 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4    2 embryonic 1182-4H    3 embryonic GM2    0 embryonic Kc167    1 embryonic S1    41 embryonic S3    5 leg disc CME L1    1 wing disc CME-W2    25 wing disc ML-DmD8    1 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    1 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    5 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    10 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    29 Ethanol 5% 3 hrs, larvae L3    21 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    20 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    26 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    23 Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    10 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3  (29) Ethanol 5% 3 hrs, larvae L3    21 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    20 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult  26 Paraquat 10 mM 48 hrs, 4-day adult  (28) Rotenone 2 μg 12 hrs, larvae L3    23 Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    10 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    29 Ethanol 5% 3 hrs, larvae L3    21 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    20 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    26 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    23 Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    10 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    29 Ethanol 5% 3 hrs, larvae L3    21 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    20 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    26 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    23 Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    10 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    29 Ethanol 5% 3 hrs, larvae L3    21 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    20 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    26 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    23 Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    10 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3  29 Ethanol 5% 3 hrs, larvae L3    21 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    20 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult  26 Paraquat 10 mM 48 hrs, 4-day adult  28 Rotenone 2 μg 12 hrs, larvae L3    23 Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    10 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    29 Ethanol 5% 3 hrs, larvae L3    21 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    20 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    26 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    23 Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    10 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    29 Ethanol 5% 3 hrs, larvae L3    21 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    20 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    26 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    23 Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_09 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • LD28328 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0016122 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10593-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Acer Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage Acerk07704 lethal | recessive Acerk07704 viable AcerΔ164 AcerΔ168 viable, with Scer\GAL4pnr-MD237 AcerGD1187 Sterility Allele fertile AcerΔ164 AcerΔ168 Other Phenotypes Allele circadian behavior defective AcerΔ164 AcerΔ168 sleep defective AcerΔ164 AcerΔ168 Phenotype manifest in Allele heart primordium Acerk07704
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of Acer Class Mutagen Stocks Known lesion Acerk07704 P-element activity 2 -- AcerCB-0338-3 1 -- AcerNP7030 1 -- AcerΔ164 Delta2-3 0 Yes AcerΔ168 Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Acer Class Mutagen Stocks Known lesion AcerGD1187 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes AcerNIG.10593R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(2L)N22-5 (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Disrupted in	Df(2L)Exel7038 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1187} NA P{NIG.10593R} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}Acerk07704 No miscellaneous insertions P{RS3}AcerCB-0338-3 NA insertion of enhancer trap binary system P{GawB}AcerNP7030 No
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function
CV term Evidence References
peptidyl-dipeptidase activity inferred from direct assay (Coates et al., 2000)
Biological Process
CV term Evidence References
heart development inferred from mutant phenotype (assigned by UniProtKB) (Crackower et al., 2002) NOT heart development inferred from mutant phenotype (Carhan et al., 2011) positive regulation of circadian sleep/wake cycle, sleep inferred from mutant phenotype (Carhan et al., 2011) sleep inferred from mutant phenotype (Carhan et al., 2011)
Cellular Component
CV term Evidence References
extracellular region inferred from direct assay (assigned by UniProtKB) (Houard et al., 1998) extracellular space inferred from direct assay (Carhan et al., 2011)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
metalloendopeptidase activity inferred from sequence or structural similarity with mouse Ace (Taylor et al., 1996) peptidyl-dipeptidase activity inferred from sequence or structural similarity with Ance (Taylor et al., 1996) inferred from sequence or structural similarity with UniProtKB:Q10715 (FlyBase, 1992-) non-traceable author statement (Spradling et al., 1999, Shirras, 1996.3.25) zinc ion binding inferred from sequence model (Taylor et al., 1996)
Biological Process
CV term Evidence References
proteolysis inferred from electronic annotation with InterPro:IPR001548 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
membrane inferred from electronic annotation with InterPro:IPR001548 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Acer - Aats-lys anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Acer - B52 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Acer - CG43444 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Acer - CG7049 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Acer - Eb1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Acer - Rab6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Acer - Rbp1-like anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Acer - RpL7-like anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Acer - Srp54 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Acer - Trap1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Acer - isoQC anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Acer allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60309 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0016122 DroID - A comprehensive database of gene and protein interactions. • FBgn0016122 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34189
Orthologs
OrthoDB Orthologs (54) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG69ZZ7Q Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search EOG6SN0HW Arthropod inclusive ortholog search EOG6ZS7J9 Metazoa inclusive ortholog search EOG64FK35
Orthologs in Drosophila Species (EOG69ZZ7Q)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Acer     Drosophila simulans   Dsim\GD23554 Y   Drosophila sechellia   Dsec\GM17055 Y   Drosophila erecta   Dere\GG25294 Y   Drosophila yakuba   Dyak\GE18785 Y   Drosophila ananassae   Dana\GF15534 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA10423 Y   Drosophila persimilis   Dper\GL26134 Y   Drosophila willistoni   Dwil\GK18674 Y   Drosophila virilis   Dvir\GJ21681 Y   Drosophila mojavensis   Dmoj\GI10464     Drosophila grimshawi   Dgri\GH10960 Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (EOG6SN0HW)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB41332 Y Atta cephalotes Leafcutter ant  Acep\ACEP24553 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO27007 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19105 Y Linepithema humile Argentine ant  Lhum\LH23526 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB15022 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI008911 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI071320 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI000733 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI084554 Y Bombyx mori Silkmoth  Bmor\BGIBMGA002526 Y Bombyx mori Silkmoth  Bmor\BGIBMGA002527 Y Pediculus humanus Human body louse  Phum\PHUM522500 Y Tribolium castaneum Red flour beetle  Tcas\TC011052 Y
Orthologs in non-Insect Arthropods (EOG6ZS7J9)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_307858 Y Daphnia pulex Water flea  Dpux\Ubl3 Y Daphnia pulex Water flea  Dpux\JGI_V11_243454 Y
Orthologs in non-Arthropod Metazoa (EOG64FK35)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\acn-1 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_027987gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015371gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_021357gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_021352gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015027gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_021355gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_028021gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026910gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_009392gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_021351gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026751gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_021354gn Y Danio rerio Zebrafish  Drer\ENSDARG00000079166 Y Danio rerio Zebrafish  Drer\ace2 Y Xenopus tropicalis Western clawed frog  Xtro\ace Y Xenopus tropicalis Western clawed frog  Xtro\ace2 Y Gallus gallus Domestic chicken  Ggal\ACE2 Y Gallus gallus Domestic chicken  Ggal\ACE Y Mus musculus House mouse  Mmus\Ace Y Mus musculus House mouse  Mmus\Ace2 Y Rattus norvegicus Norway rat  Rnor\Ace Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000031665 Y Homo sapiens Human  Hsap\ACE2 Y Homo sapiens Human  Hsap\ACE Y
Human Orthologs (2)
Gene OMIM HGNC Hsap\ACE2     Hsap\ACE
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD23554 Drosophila sechellia Dsec\GM17055 Drosophila erecta Dere\GG25294 Drosophila yakuba Dyak\GE18785 Drosophila ananassae Dana\GF15534 Drosophila pseudoobscura pseudoobscura Dpse\GA10423 Drosophila persimilis Dper\GL26134 Drosophila willistoni Dwil\GK18674 Drosophila virilis Dvir\GJ21681 Drosophila grimshawi Dgri\GH10960
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	10679 y1 w67c23; P{lacW}Acerk07704/CyO
Kyoto	123134 w1118; P{RS3}AcerCB-0338-3 105339 y* w*; P{GawB}AcerNP7030 / CyO, P{UAS-lacZ.UW14}UW14 111221 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{lacW}Acerk07704 P{neoFRT}40A/CyO y+
VDRC	v3324 w1118; P{GD1187}v3324/TM3
Genomic Clones ( 2 )
	BACR02I15 BACR23B08 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 167 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD28328
Other clones	DPiM_LD28328
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT01377 AT04352 AT04929 AT08552 AT08760 AT09020 AT09587 AT10004 AT12143 AT12908 AT13678 AT15569 AT15581 AT16852 AT17249 AT17510 AT17709 AT18407 AT19246 AT19770 AT20861 AT21789 AT22723 AT22754 AT22843 AT22977 AT23629 AT23812 AT24295 AT25144 AT25659 AT26070 AT26283 AT27736 AT27855 AT28517 AT30008 AT30149 AT30862 AT31321 AT31505 GH03549 GH09527 GH10016 GH10096 GH10863 GH11904 GH14063 GH24152 GH25125 GH28684 GM01822 HL05456 LD17687 LD26534 LD28059 LD44393 RE05840 RE06842 RE08064 RE11262 RE11380 RE14769 RE21844 RE22880 RE22934 RE30569 RE36134 RE36177 RE38225 RE42528 RE43012 RE43481 RE45872 RE50390 RE53813 RE53913 RE58810 RE63530 RE64361 RE64582 RE66167 RE66423 RE67167 RE67307 RE68187 RE69187 RE70337 RH02165 RH03481 RH04052 RH05688 RH06245 RH13929 RH14825 RH21017 RH36222 RH38750 RH60939 RH68117 RH73660 SD13311 SD17007
Other clones	34941 58775 59056 62805 63683 74564 103932 214215.5 281637 AT01139 bs12g11 bs47f11 bs66c03 CK01.41A.B12 CK01.41D.B12 CK01.90B.A6 CK01.91A.C11 CK01.92B.D10 CK01.105B.E12 CK01.117B.E8 CK01233 CK02601 Dmel_neb_016004_0882_1719 EC22064 EC052920 EC053006 EC053942 EC053956 EC054953 EK035230 EK070935 EK071212 EK072047 EK076007 EK080450 EK085303 EK091539 EK183138 EK188456 EK190529 EK227132 EK307010 EK307706 EP12758 IP10124 RM07506 RM07606 RM07706 RM07806 RM08006 RM08106 RP01218 RP001004569 RP001010033 RP001018076 RP001020244 RP001021871 RP001024075 RP001033652 RP001035450 RP001037134 RP001056226
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0016122 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34189
Antibody Information
	polyclonal (Carhan et al., 2011)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Acer l(2)k07704 (Spradling et al., 1999)
Additional comments
Other Comments
	Identified as a gene with significant level of mRNA cycling as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day. (McDonald and Rosbash, 2001) Acer mRNA is found in the dorsal vessel during embryogenesis. Phylogenetic analysis indicates that duplication of an ancestral ACE gene occurred in the lineage leading to the arthropods (Ance and Acer), independently of the lineage that gave rise to the two domain somatic ACE of mammals. (Taylor et al., 1996)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057847 NM_001273329 RefSeq (Proteins) • NP_477195 NP_001260258 DDBJ / EMBL / GenBank • AA539520 AA942373 AA949506 AAF52693 AAK93174 AC004728 AC008330 AGB92794 AI945433 AQ025842 AW942882 AY051750 CAA65632 X96913 Entrez Gene - A searchable database of RefSeq genes. • 34189 UniProtKB/Swiss-Prot • Q9VLJ6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Peptidase M2, peptidyl-dipeptidase A (IPR001548) MEROPS - An information resource for peptidases and the proteins that inhibit them • M02.002 BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD28328
Linkouts
	BioGRID - A database of protein and genetic interactions • 60309 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0016122 DroID - A comprehensive database of gene and protein interactions. • FBgn0016122 DRSC - Results from RNAi screens. • FBgn0016122 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0016122 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10593-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0016122 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34189 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34189 modMine - Data generated by the modENCODE project. • FBgn0016122
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	ACE (Coates et al., 1993) ACER (Crackower et al., 2002, Bingham et al., 2006) Acer (Weake et al., 2008, Carhan et al., 2011, Carrera et al., 2008, Girardot et al., 2004, Kaplow et al., 2007, Wilson et al., 2002, Siviter et al., 2002, Rylett et al., 2007, Japanese National Institute of Genetics, 2012.5.21) CG10593 (Carrera et al., 2008) l(2)k07704 (BDGP Project Members, 1994-1999, )
Name Synonym	Angiotensin-converting enzyme-related (Carhan et al., 2011, Kaplow et al., 2007) angiotensin-converting enzyme-related (Bingham et al., 2006)
Secondary FlyBase IDs
	FBgn0022076
References ( 49 )
Generate a list of	All references relating to this gene ( 49 )
List References by type	Research paper  ( 19 ) Supplementary material  ( 5 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 8 ) FlyBase analysis  ( 3 ) Stock list  ( 1 ) DNA/RNA sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 2 )
	Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Carhan et al., 2011, J. Exp. Biol. 214(4): 680--686 Loss of Angiotensin-converting enzyme-related (ACER) peptidase disrupts night-time sleep in adult Drosophila melanogaster. [FBrf0212867] Show all research papers ...