FB2021_02, released April 13, 2021

Gene: Dmel\Alp4

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General Information
Symbol
Dmel\Alp4
Species
D. melanogaster
Name
Alkaline phosphatase 4
Annotation Symbol
CG1462
Feature Type
protein_coding_gene
FlyBase ID
FBgn0016123
Gene Model Status
Current
Stock Availability
7 publicly available
Gene Summary
Important role in neural and renal epithelial function. (UniProt, Q24238)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

Aph-4, l(3)07028

Key Links
Genomic Location
Cytogenetic map
100B1-100B1
Sequence location
3R:31,048,929..31,052,540 [+]
Recombination map
3-102
RefSeq locus
NT_033777 REGION:31048929..31052540
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (8 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables alkaline phosphatase activity
inferred from sequence or structural similarity with HGNC:439
(FlyBase Curators, 2008--)
inferred from biological aspect of ancestor with PANTHER:PTN000174527
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in epithelial fluid transport
inferred from mutant phenotype
(assigned by UniProt )
(Yang et al., 2000)
involved_in multicellular organism reproduction
inferred from high throughput expression pattern
(Mueller et al., 2005)
inferred from expression pattern
(Swanson et al., 2001)
involved_in nervous system development
inferred from expression pattern
(assigned by UniProt )
(Yang et al., 2000)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in dephosphorylation
inferred from sequence or structural similarity with HGNC:439
(FlyBase Curators, 2008--)
inferred from biological aspect of ancestor with PANTHER:PTN000174527
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
located_in cell surface
inferred from sequence or structural similarity with HGNC:439
(FlyBase Curators, 2008--)
located_in extracellular region
inferred from sequence model
(Swanson et al., 2001)
located_in extracellular space
inferred from sequence model
(Mueller et al., 2005)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the alkaline phosphatase family. (Q24238)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
ALKALINE PHOSPHATASES -
Alkaline phosphatases function best in alkaline environments, catalyzing the hydrolysis of monoesters of phosphoric acid and a transphosphorylation reaction in the presence of large concentrations of phosphate acceptors. With few exceptions, they are homodimeric enzymes and each catalytic site contains three metal ions, i.e., two Zn and one Mg, necessary for enzymatic activity. They have broad substrate specificity. (Adapted from PMID:18404473.)
Protein Function (UniProtKB)
Important role in neural and renal epithelial function.
(UniProt, Q24238)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Alp4 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Alp4-RA
FBtr0085733
NM_079862
2153
596
Alp4-RB
FBtr0085734
NM_170534
2021
502
Additional Transcript Data and Comments
Reported size (kB)

2.05 (northern blot)

(Kloss et al., 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Alp4-PA
FBpp0085095
65.3
596
6.26
NP_524601
AAF57106
Alp4-PB
FBpp0085096
54.9
502
6.06
NP_733413
AAN14265
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)

578 (aa)

(Yang et al., 2000)
Comments
External Data
Subunit Structure (UniProtKB)

Homodimer.

(UniProt, Q24238)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Alp4 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage & adult stage
(Yang et al., 2000)
adult stage
Malpighian tubule
(Yang et al., 2000)
ellipsoid body
(Yang et al., 2000)
Additional Descriptive Data

Aph-4 transcript levels are highest in larvae and adults. Aph-4 transcripts are detected by in situ hybridization in ellipsoid bodies in adult brain and in Malpighian tubules.

(Yang et al., 2000)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
Reporter: P{GawB}Alp4c232
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
ureter
(Sozen et al., 1997)
Malpighian tubule | restricted
(Sozen et al., 1997)
ellipsoid body
(O'Dell et al., 1995)
pupal stage P7 -- adult stage
ring neuron R3
(Young and Armstrong, 2010)
ring neuron R4d
(Young and Armstrong, 2010)
adult stage
ring neuron of ellipsoid body | subset
(Zars et al., 2000)
ring neuron R3
(Flybrain Neuron Database et al., 2018.6.28, Chen et al., 2012, Young and Armstrong, 2010, Baker et al., 2007, Yang et al., 2000, Renn et al., 1999)
Malpighian tubule
(Yang et al., 2000)
ellipsoid body
(Yang et al., 2000, Connolly et al., 1996)
ring neuron R4 | distal | subset
(Renn et al., 1999)
ring neuron R4
(Baker et al., 2007, Yang et al., 2000)
ellipsoid body | restricted
(Young and Armstrong, 2010, Zars et al., 2000, Renn et al., 1999)
ureter
(Yang et al., 2000, Sozen et al., 1997)
large field neuron | subset
(Renn et al., 1999)
main segment of Malpighian tubule | restricted
(Sozen et al., 1997)
adult brain | restricted
(Connolly et al., 1996)
ring neuron R4d
(Flybrain Neuron Database et al., 2018.6.28, Chen et al., 2012, Young and Armstrong, 2010)
ring neuron R3 | subset
(Bridi et al., 2019)
ring neuron R4d | subset
(Bridi et al., 2019)
Reporter: P{GawB}Alp4c507
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
ureter
(Sozen et al., 1997)
Malpighian tubule | restricted
(Sozen et al., 1997)
transitional segment of Malpighian tubule
(Sozen et al., 1997)
third instar larval stage
ring neuron R3
(Renn et al., 1999)
adult stage
ring neuron R3
(Martín-Peña et al., 2014, Yang et al., 2000, Renn et al., 1999)
Malpighian tubule
(Yang et al., 2000)
ellipsoid body
(Yang et al., 2000)
ring neuron R4 | distal | subset
(Renn et al., 1999)
ring neuron R4
(Cavanaugh et al., 2014, Yang et al., 2000)
ellipsoid body | restricted
(Renn et al., 1999)
ureter
(Yang et al., 2000, Sozen et al., 1997)
large field neuron | subset
(Renn et al., 1999)
main segment of Malpighian tubule | restricted
(Sozen et al., 1997)
adult pars intercerebralis | restricted
(Cavanaugh et al., 2014)
ring neuron R1
(Martín-Peña et al., 2014)
ring neuron R2
(Martín-Peña et al., 2014)
ring neuron R4m
(Martín-Peña et al., 2014)
ring neuron R3 | subset
(Bridi et al., 2019)
ring neuron R4d | subset
(Bridi et al., 2019)
Reporter: P{PZ}Alp407028
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
ureter
(Yang et al., 2000)
Malpighian tubule
(Yang et al., 2000)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Alp4 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 3 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Alp4
Transgenic constructs containing regulatory region of Alp4
Aberrations (Deficiencies and Duplications) ( 3 )
Inferred from experimentation ( 3 )
Gene not disrupted in
Df(3R)tll-e
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
Gene disrupted in
Df(3R)Exel6260
(Ryder, 2004.4.26)
T(Y;3)R133
(BDGP Project Members, 1994-1999)
Inferred from location ( 0 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ALPP
7 of 15
Yes
No
Hsap\ALPG
6 of 15
No
No
Hsap\ALPI
6 of 15
No
No
Hsap\ALPL
6 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Alpi
7 of 15
Yes
No
Mmus\Akp3
6 of 15
No
No
Mmus\Alpl
6 of 15
No
No
Mmus\Alppl2
6 of 15
No
No
Rattus norvegicus (Norway rat) (5)
Rnor\Alpi
7 of 13
Yes
No
Rnor\Alpg
6 of 13
No
Yes
Rnor\Alpl
6 of 13
No
No
Rnor\Alpp
5 of 13
No
No
Rnor\Akp3
4 of 13
No
No
Xenopus tropicalis (Western clawed frog) (3)
Xtro\alpi.1
5 of 12
Yes
No
Xtro\alpl
5 of 12
Yes
No
Xtro\alpi.2
1 of 12
No
No
Danio rerio (Zebrafish) (4)
Drer\alpi.2
6 of 15
Yes
No
Drer\alpl
6 of 15
Yes
No
Drer\alpi.1
5 of 15
No
No
Drer\alp3
3 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (0)
No records found.
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\PHO8
9 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\SPBC14F5.13c
7 of 12
Yes
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091906RF )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00009156
Drosophila simulans
Dsim\GD21558
Drosophila sechellia
Dsec\GM12919
Drosophila erecta
Dere\GG11789
Drosophila yakuba
Dyak\GE10917
Drosophila ananassae
Dana\GF22935
Drosophila pseudoobscura pseudoobscura
Dpse\GA13119
Drosophila persimilis
Dper\GL13536
Drosophila willistoni
Dwil\GK22608
Drosophila virilis
Dvir\GJ10501
Drosophila mojavensis
Dmoj\GI22314
Drosophila grimshawi
Dgri\GH13970
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091502O7 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17018174
Glossina morsitans
Tsetse fly
Gmor\GMOY004885
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_11821
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL000931
Anopheles darlingi
American malaria mosquito
Adar\ADAC008590
Anopheles gambiae
Malaria mosquito
Agam\AGAP010596
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W071J )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA011462
Bombyx mori
Silkmoth
Bmor\BGIBMGA014304
Bombyx mori
Silkmoth
Bmor\BGIBMGA009872
Bombyx mori
Silkmoth
Bmor\BGIBMGA008818
Bombyx mori
Silkmoth
Bmor\BGIBMGA011463
Bombyx mori
Silkmoth
Bmor\BGIBMGA008401
Bombyx mori
Silkmoth
Bmor\BGIBMGA008824
Bombyx mori
Silkmoth
Bmor\BGIBMGA009866
Danaus plexippus
Monarch butterfly
Dple\DPOGS200818-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS210009-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS200817-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS215259-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS209233-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS215263-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS215432-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL016348
Heliconius melpomene
Postman butterfly
Hmel\HMEL010183
Heliconius melpomene
Postman butterfly
Hmel\HMEL016167
Heliconius melpomene
Postman butterfly
Hmel\HMEL017513
Heliconius melpomene
Postman butterfly
Hmel\HMEL013752
Heliconius melpomene
Postman butterfly
Hmel\HMEL013037
Apis florea
Little honeybee
Aflo\2322783764
Apis florea
Little honeybee
Aflo\2216906772
Apis florea
Little honeybee
Aflo\3446728468
Apis mellifera
Western honey bee
Amel\GB55499
Apis mellifera
Western honey bee
Amel\GB52063
Apis mellifera
Western honey bee
Amel\LOC410530
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP20243
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP19667
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP16694
Bombus terrestris
Buff-tailed bumblebee
Bter\15206170
Bombus terrestris
Buff-tailed bumblebee
Bter\15213365
Bombus terrestris
Buff-tailed bumblebee
Bter\15214776
Linepithema humile
Argentine ant
Lhum\LH11167
Linepithema humile
Argentine ant
Lhum\LH20731
Linepithema humile
Argentine ant
Lhum\LH15311
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001b20
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000a95
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001184
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG001233
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG004816
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07524
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_04596
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_01036
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02703
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_05624
Tribolium castaneum
Red flour beetle
Tcas\TC032020
Tribolium castaneum
Red flour beetle
Tcas\TC034155
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_07539
Pediculus humanus
Human body louse
Phum\PHUM193940
Pediculus humanus
Human body louse
Phum\PHUM129520
Pediculus humanus
Human body louse
Phum\PHUM251300
Pediculus humanus
Human body louse
Phum\PHUM129510
Rhodnius prolixus
Kissing bug
Rpro\RPRC001092
Rhodnius prolixus
Kissing bug
Rpro\RPRC014817
Rhodnius prolixus
Kissing bug
Rpro\RPRC001113
Rhodnius prolixus
Kissing bug
Rpro\RPRC009958
Rhodnius prolixus
Kissing bug
Rpro\RPRC006863
Cimex lectularius
Bed bug
Clec\CLEC003059
Cimex lectularius
Bed bug
Clec\CLEC008087
Cimex lectularius
Bed bug
Clec\CLEC004940
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI009772
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI007899
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI39787
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI001572
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI063759
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006024
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004083
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006455
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_11692
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_01430
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_11690
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_05461
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_05460
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X06WR )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR007320
Ixodes scapularis
Black-legged tick
Isca\ISCW023785
Ixodes scapularis
Black-legged tick
Isca\ISCW000162
Stegodyphus mimosarum
African social velvet spider
Smim\KFM57384.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM58295.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM59700.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM56639.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM70846.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM58294.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur05g00330
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_251266
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_194087
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_269431
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_328304
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_228306
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_319945
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G067H )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Alpl_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_016431gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_016433gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Alpl_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Alpl
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Alpi
Ciona intestinalis
Vase tunicate
Cint\LOC100175777
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000021280
Ciona intestinalis
Vase tunicate
Cint\LOC100178630
Ciona intestinalis
Vase tunicate
Cint\ciap
Ciona intestinalis
Vase tunicate
Cint\LOC101243300
Ciona intestinalis
Vase tunicate
Cint\LOC100176308
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000023866
Gallus gallus
Domestic chicken
Ggal\LOC100859876
Gallus gallus
Domestic chicken
Ggal\ALPL
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (12)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Alp1
6 of 10
Alp5
6 of 10
Alp6
6 of 10
Alp9
6 of 10
Alp10
6 of 10
Alp11
6 of 10
Alp12
6 of 10
phu
6 of 10
Alp2
5 of 10
Alp7
5 of 10
Alp8
5 of 10
Alp13
3 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ALPP; alkaline phosphatase, placental
    7 of 15
    171800
        ALPG; alkaline phosphatase, germ cell
        6 of 15
        171810
            ALPI; alkaline phosphatase, intestinal
            6 of 15
            171740
                ALPL; alkaline phosphatase, biomineralization associated
                6 of 15
                171760
                Functional Complementation Data
                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                Interactions
                Summary of Physical Interactions
                esyN Network Diagram
                Interactions Browser
                Summary of Genetic Interactions
                esyN Network Diagram
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                External Data
                Subunit Structure (UniProtKB)
                Homodimer.
                (UniProt, Q24238 )
                Linkouts
                DroID - A comprehensive database of gene and protein interactions.
                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                Pathways
                Signaling Pathways (FlyBase)
                Metabolic Pathways
                External Data
                Linkouts
                KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                Genomic Location and Detailed Mapping Data
                Chromosome (arm)
                3R
                Recombination map
                3-102
                Cytogenetic map
                100B1-100B1
                Sequence location
                3R:31,048,929..31,052,540 [+]
                FlyBase Computed Cytological Location
                Cytogenetic map
                Evidence for location
                100B1-100B1
                Limits computationally determined from genome sequence between P{PZ}Aph-407028&P{PZ}dcorK215 and P{PZ}l(3)rM731rM731
                Experimentally Determined Cytological Location
                Cytogenetic map
                Notes
                References
                100B2-100B2
                (determined by in situ hybridisation) 100B (determined by in situ hybridisation)
                (Yang et al., 2000)
                100B4-100B5
                (Yang, 1996.6.8)
                100B1-100B2
                (determined by in situ hybridisation)
                (Spradling et al., 1999)
                100B1-100B2
                (BDGP Project Members, 1994-1999)
                Experimentally Determined Recombination Data
                Location

                3-102

                (FlyBase, 2016)

                3-98.9

                (Comeron et al., 2012)

                3-

                (Yang, 1996.6.8)
                Left of (cM)
                Right of (cM)
                Notes
                Stocks and Reagents
                Stocks (7)
                Genomic Clones (14)
                 

                Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                cDNA Clones (26)
                 

                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                cDNA clones, fully sequenced
                BDGP DGC clones
                Other clones
                Drosophila Genomics Resource Center cDNA clones

                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                cDNA Clones, End Sequenced (ESTs)
                BDGP DGC clones
                Other clones
                RNAi and Array Information
                Linkouts
                DRSC - Results frm RNAi screens
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                Antibody Information
                Laboratory Generated Antibodies
                 
                Commercially Available Antibodies
                 
                Other Information
                Relationship to Other Genes
                Source for database identify of

                Source for identity of: Aph-4 CG1462

                (Yao, 1999.11)

                Source for identity of: Alp4 Aph-4

                (Marygold, 2015.6.26)
                Source for database merge of

                Source for merge of: Aph-4 l(3)07028

                (Yang et al., 2000)
                Additional comments

                Renamed from 'Aph-4' to Alp4' to be consistent with the nomenclature of other named Dmel genes encoding Alkaline phosphatases and the mammalian nomenclature.

                (Marygold, 2015.6.26)
                Other Comments

                Isolated in a screen for seminal fluid proteins.

                (Mueller et al., 2004)
                Origin and Etymology
                Discoverer
                Etymology
                Identification
                External Crossreferences and Linkouts ( 42 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                Other crossreferences
                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                Flygut - An atlas of the Drosophila adult midgut
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                InterPro - A database of protein families, domains and functional sites
                KEGG Genes - Molecular building blocks of life in the genomic space.
                modMine - A data warehouse for the modENCODE project
                Linkouts
                DroID - A comprehensive database of gene and protein interactions.
                DRSC - Results frm RNAi screens
                FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                FlyMine - An integrated database for Drosophila genomics
                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                Synonyms and Secondary IDs (10)
                Datasets (0)
                Study focus (0)
                Experimental Role
                Project
                Project Type
                Title
                References (63)