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Gene Dmel\CaMKI

General Information
Symbol	Dmel\CaMKI	Species	D. melanogaster
Name	Calcium/calmodulin-dependent protein kinase I	Annotation symbol	CG1495
Feature type	protein_coding_gene	FlyBase ID	FBgn0016126
Gene Model Status	Current	Stock availability	7 publicly available
Genomic Location
Chromosome (arm)	4	Recombination map
Cytogenetic map	102C1-102C1	Sequence location	4:466,130..474,573 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Calcium/calmodulin-dependent protein kinase I is referred to in FlyBase by the symbol Dmel\CaMKI (CG1495, FBgn0016126). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: calmodulin-dependent protein kinase activity. Based on sequence similarity, it is predicted to be involved in the biological process: protein phosphorylation. 9 alleles are reported. No phenotypic data is available. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: Calcium/calmodulin-dependent/calcium-dependent protein kinase; Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine- / dual specificity protein kinase, catalytic domain; Serine/threonine-protein kinase, active site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 12-18 embryonic stages, during late larval stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult hindgut, adult heart, larval/adult fat body, larval salivary gland, larval trachea, adult spermathecae, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult midgut, larval Malpighian tubules, adult salivary gland, adult ovary, adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1637380_s_at completely aligns to an exonic region common to each of the 7 FlyBase-annotated transcript isoforms of CaMKI. Gene sequence location is 4:466130..474573.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 102C1-102C1
Experimentally Determined Cytological Location
Cytogenetic map Notes References 102B7-102B8     (Montell, 1998.8.11) 102B7-102B8   (determined by in situ hybridisation)   (Xu et al., 1998)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CaMKI for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Annotated transcripts do not represent all supported alternative splices within 5' UTR. Gene model reviewed during 5.46 Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CaMKI-RA FBtr0089067  NM_166759   2239   405 CaMKI-RB FBtr0089069  NM_166760   2580   405 CaMKI-RG FBtr0089065  NM_079883   3382   405 CaMKI-RH FBtr0089063  NM_166764   1950   284 CaMKI-RI FBtr0333670  NM_166761   2604   390
Additional Transcript Data & Comments
Reported size (kB)	3.5 (northern blot) (Xu et al., 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CaMKI-PA   FBpp0088136   45.1   405   6.74     NP_726569   AAN06531 CaMKI-PB   FBpp0088138   45.1   405   6.74     NP_726570   AAF59344 CaMKI-PG   FBpp0088134   45.1   405   6.74     NP_524622   AAF59343 CaMKI-PH   FBpp0088132   31.5   284   5.15     NP_726574   AAN06535 CaMKI-PI   FBpp0305826   43.5   390   6.52     NP_726571   AAN06532
Additional Polypeptide Data & Comments
Reported size (kDa)	405 (aa) (Xu et al., 1998)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine- / dual specificity protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Calcium/calmodulin-dependent/calcium-dependent protein kinase (IPR020636)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA538772   AA539219   AA541026   AA567847   AA697674   AA697675   AE014135 AAF59343   AE014135 AAF59344   AE014135 AAN06531   AE014135 AAN06532   AE014135 AAN06535   AC012390   AI062027   AI064519   AI107009   AI238289   AI297378   AI403651   AI403903   AI517652   AW940186   AY231728   BG632293   BG632810   BI164145   BI164176   BI165255   BI167151   BI170540   BI215521   BI228495   BI232533   BI232840   BI233035   BI233148   BI238618   BI239590   BI240884   BI242426   BI358210   BI363217   BI370736   BI483029   BI485255   BI487036   BI568500   BI578320   BQ103619   BT001553 AAN71308   BT001637 AAN71392   BT003311 AAO25071   CA804015   CA804629   CA804864   CA806472   CA806748   CA806986   CK659197   CK661811   CL527989   CO176791   CO180787   CO180892   CO181939   CO184827   CO184941   CO185172   CO185901   CO188260   CO190561   CO192258   CO193465   CO195903   CO196510   CO262018   CO262340   CO264302   CO266325   CO266413   CO269443   CO270259   CO271269   CO271289   CO271536   CO271945   CO273359   CO274177   CO275443   CO275587   CO275690   CO277490   CO278917   CO280307   CO282127   CO282526   CO283763   CO287236   CO288932   CO288970   CO291309   CO293300   CO293655   CO301635   CO304559   CO304789   CO305841   CO306258   CO315567   CO319731   CO320193   CO322144   CO322173   CO323769   CO324453   CO325740   CO327667   CO328088   CO328640   CO330896   CO330985   CO334022   CO334146   CO340316   CO340927   CO342700   CO343395   CZ482564   CZ486445   CZ486446   EC051526   EC051528   EC052522   EC053518   EC055003   EC055358   EC056104   EC060064   EC060593   EC065005   EC065401   EC070540   EC070962   EC071001   EC071641   EC071767   EC071835   EC072171   EC072403   EC074580   EC075620   EC079050   EC079470   EC081296   EC081922   EC082016   EC082337   EC082802   EC084499   EC086195   EC088536   EC090420   EC197614   EC200543   EC203323   EC208679   EC209324   EC212573   EC214423   EC214541   EC215252   EC215897   EC216785   EC218531   EC222489   EC222955   EC223477   EC224420   EC225821   EC225839   EC227566   EC228807   EC229139   EC231679   EC233535   EC235269   EC236950   EC237387   EC238944   EC241410   EC244032   EC244173   EC244885   EC247181   EC249312   EC249729   EC250948   EC253264   EC253610   EC253721   EC255640   EC255901   EC258804   EC260315   GH749475   GH750453   GH750860   GH752503   GH752720   GH752862   GH755901   GH757460   GH757950   GH758924   GH774303   GH777495   GH777954   GH780100   GH781356   GH785111   GH785545   GH786672   GH789269   GH790564   GH792732   GH794498   GH796103   GH796868   GH796933   GH796968   GH797832   GH799470   GH804858   GH806721   GH808741   GH809039   GH809735   GH812125   GH812643   GH813106   GH816486   GH816934   GH818319   GH823631   GH823689   GH830431   GH831532   GH832976   GH837391   GH837518   GH838257   GH838896   GH841680   GH842590   GH846782   GH847005   GH847577   GH854697   GH856484   GH859053   GH865589   GH865748   GH867632   GH871331   GH872445   GH874233   GH875859   GH876709   GH881849   GH884787   GH894991   GH896722   GH898279   GH901997   GH903563   GH908673   GH912137   GH912964   GH918939   GH919390   GH920624   GH921999   GH926891   GH929820   GH931978   GH933923   GH937896   Y17917 CAA76937
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7JMV3 Q0KIF7 Q86P88 Q8IGW6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference larval stage & pupal stage & adult stage     (Xu et al., 1998) adult stage   eye   (Xu et al., 1998)   (Xu et al., 1998)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult hindgut, adult heart, larval/adult fat body, larval salivary gland, larval trachea, adult spermathecae, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult midgut, larval Malpighian tubules, adult salivary gland, adult ovary, adult male accessory gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1270.425 Larval Midgut    247.2 Larval Hindgut    816 Larval Malpighian Tubules    150.1 Larval Fat Body    3634.3 Larval Salivary Gland    1240.3 Larval Trachea    989.15 Larval Carcass    757.3 Adult Head    1525 Adult Eye    1173.1 Adult Brain    1587.4 Adult Thoracic-Abdominal Ganglion    1786.5 Adult Crop    1965.5 Adult Midgut    263.7 Adult Hindgut    985.4 Adult Malpighian Tubules    92.1 Adult Fat Body    3622.9 Adult Salivary Gland    317.5 Adult Heart    1955.325 Adult VirginFemale Spermatheca    3894.9 Adult InseminatedFemale Spermatheca    3183.9 Adult Ovary    417.6 Adult Testis    78.5 Adult Male Accessory Gland    398.7 Adult Carcass    1747.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1270.425) Larval Midgut    247.2 Larval Hindgut  (816) Larval Malpighian Tubules    150.1 Larval Fat Body  (3634.3) Larval Salivary Gland  (1240.3) Larval Trachea  (989.15) Larval Carcass  (757.3) Adult Head  (1525) Adult Eye  (1173.1) Adult Brain  (1587.4) Adult Thoracic-Abdominal Ganglion  (1786.5) Adult Crop  (1965.5) Adult Midgut    263.7 Adult Hindgut  (985.4) Adult Malpighian Tubules    92.1 Adult Fat Body  (3622.9) Adult Salivary Gland    317.5 Adult Heart  (1955.325) Adult VirginFemale Spermatheca  (3894.9) Adult InseminatedFemale Spermatheca  (3183.9) Adult Ovary    417.6 Adult Testis    78.5 Adult Male Accessory Gland    398.7 Adult Carcass  (1747.7) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (1270.425) Larval Midgut    247.2 Larval Hindgut    816 Larval Malpighian Tubules    150.1 Larval Fat Body  (3634.3) Larval Salivary Gland  (1240.3) Larval Trachea    989.15 Larval Carcass    757.3 Adult Head  (1525) Adult Eye  (1173.1) Adult Brain  (1587.4) Adult Thoracic-Abdominal Ganglion  (1786.5) Adult Crop  (1965.5) Adult Midgut    263.7 Adult Hindgut    985.4 Adult Malpighian Tubules    92.1 Adult Fat Body  (3622.9) Adult Salivary Gland    317.5 Adult Heart  (1955.325) Adult VirginFemale Spermatheca  (3894.9) Adult InseminatedFemale Spermatheca  (3183.9) Adult Ovary    417.6 Adult Testis    78.5 Adult Male Accessory Gland    398.7 Adult Carcass  (1747.7) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1270.425 Larval Midgut    247.2 Larval Hindgut    816 Larval Malpighian Tubules    150.1 Larval Fat Body    3634.3 Larval Salivary Gland    1240.3 Larval Trachea    989.15 Larval Carcass    757.3 Adult Head    1525 Adult Eye    1173.1 Adult Brain    1587.4 Adult Thoracic-Abdominal Ganglion    1786.5 Adult Crop    1965.5 Adult Midgut    263.7 Adult Hindgut    985.4 Adult Malpighian Tubules    92.1 Adult Fat Body    3622.9 Adult Salivary Gland    317.5 Adult Heart    1955.325 Adult VirginFemale Spermatheca    3894.9 Adult InseminatedFemale Spermatheca    3183.9 Adult Ovary    417.6 Adult Testis    78.5 Adult Male Accessory Gland    398.7 Adult Carcass    1747.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1270.425 Larval Midgut    247.2 Larval Hindgut    816 Larval Malpighian Tubules    150.1 Larval Fat Body    3634.3 Larval Salivary Gland    1240.3 Larval Trachea    989.15 Larval Carcass    757.3 Adult Head    1525 Adult Eye    1173.1 Adult Brain    1587.4 Adult Thoracic-Abdominal Ganglion    1786.5 Adult Crop    1965.5 Adult Midgut    263.7 Adult Hindgut    985.4 Adult Malpighian Tubules    92.1 Adult Fat Body    3622.9 Adult Salivary Gland    317.5 Adult Heart    1955.325 Adult VirginFemale Spermatheca    3894.9 Adult InseminatedFemale Spermatheca    3183.9 Adult Ovary    417.6 Adult Testis    78.5 Adult Male Accessory Gland    398.7 Adult Carcass    1747.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1270.425) Larval Midgut    247.2 Larval Hindgut  (816) Larval Malpighian Tubules    150.1 Larval Fat Body  (3634.3) Larval Salivary Gland  (1240.3) Larval Trachea  (989.15) Larval Carcass  757.3 Adult Head  (1525) Adult Eye  (1173.1) Adult Brain  (1587.4) Adult Thoracic-Abdominal Ganglion  (1786.5) Adult Crop  (1965.5) Adult Midgut    263.7 Adult Hindgut  (985.4) Adult Malpighian Tubules    92.1 Adult Fat Body  (3622.9) Adult Salivary Gland    317.5 Adult Heart  (1955.325) Adult VirginFemale Spermatheca  (3894.9) Adult InseminatedFemale Spermatheca  (3183.9) Adult Ovary    417.6 Adult Testis    78.5 Adult Male Accessory Gland    398.7 Adult Carcass  (1747.7) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  1270.425 Larval Midgut    247.2 Larval Hindgut    816 Larval Malpighian Tubules    150.1 Larval Fat Body  (3634.3) Larval Salivary Gland  1240.3 Larval Trachea    989.15 Larval Carcass    757.3 Adult Head  1525 Adult Eye  1173.1 Adult Brain  1587.4 Adult Thoracic-Abdominal Ganglion  (1786.5) Adult Crop  (1965.5) Adult Midgut    263.7 Adult Hindgut    985.4 Adult Malpighian Tubules    92.1 Adult Fat Body  (3622.9) Adult Salivary Gland    317.5 Adult Heart  (1955.325) Adult VirginFemale Spermatheca  (3894.9) Adult InseminatedFemale Spermatheca  (3183.9) Adult Ovary    417.6 Adult Testis    78.5 Adult Male Accessory Gland    398.7 Adult Carcass  (1747.7) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1270.425 Larval Midgut    247.2 Larval Hindgut    816 Larval Malpighian Tubules    150.1 Larval Fat Body    3634.3 Larval Salivary Gland    1240.3 Larval Trachea    989.15 Larval Carcass    757.3 Adult Head    1525 Adult Eye    1173.1 Adult Brain    1587.4 Adult Thoracic-Abdominal Ganglion    1786.5 Adult Crop    1965.5 Adult Midgut    263.7 Adult Hindgut    985.4 Adult Malpighian Tubules    92.1 Adult Fat Body    3622.9 Adult Salivary Gland    317.5 Adult Heart    1955.325 Adult VirginFemale Spermatheca    3894.9 Adult InseminatedFemale Spermatheca    3183.9 Adult Ovary    417.6 Adult Testis    78.5 Adult Male Accessory Gland    398.7 Adult Carcass    1747.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1525   NA  Eye    1173.1   NA  Brain    1587.4   1270.425  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1786.5   NA  Crop    1965.5   247.2  Midgut    263.7   816  Hindgut    985.4   150.1  Malpighian Tubules    92.1   3634.3  Fat Body    3622.9   1240.3  Salivary Gland    317.5   NA  Heart    1955.325   989.15  Trachea    NA   NA  VirginFemale Spermatheca    3894.9   NA  InseminatedFemale Spermatheca    3183.9   NA  Ovary    417.6   NA  Testis    78.5   NA  Male Accessory Gland    398.7   757.3  Carcass    1747.7 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    34 central nervous system, pupae P8    53 head, virgin 1-day female    38 head, virgin 4-day female    43 head, virgin 20-day female    50 head, mated 1-day female    28 head, mated 4-day female    44 head, mated 20-day female    43 head, mated 1-day male    50 head, mated 4-day male    64 head, mated 20-day male    75 salivary gland, larvae L3 wandering    29 salivary gland, white prepupae    38 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    10 digestive system, 4-day adult    7 digestive system, 20-day adult    6 fat body, larvae L3 wandering    48 fat body, white prepupae    59 fat body, pupae P8    14 carcass, larvae L3 wandering    17 carcass, 1-day adult    28 carcass, 4-day adult    29 carcass, 20-day adult    29 ovary, virgin 4-day female    26 ovary, mated 4-day female    17 testis, mated 4-day male    2 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3  (34) central nervous system, pupae P8  (53) head, virgin 1-day female  (38) head, virgin 4-day female  (43) head, virgin 20-day female  (50) head, mated 1-day female  (28) head, mated 4-day female  (44) head, mated 20-day female  (43) head, mated 1-day male  (50) head, mated 4-day male  (64) head, mated 20-day male  (75) salivary gland, larvae L3 wandering  (29) salivary gland, white prepupae  (38) digestive system, larvae L3 wandering    10 digestive system, 1-day adult    10 digestive system, 4-day adult    7 digestive system, 20-day adult    6 fat body, larvae L3 wandering  (48) fat body, white prepupae  (59) fat body, pupae P8    14 carcass, larvae L3 wandering    17 carcass, 1-day adult  (28) carcass, 4-day adult  (29) carcass, 20-day adult  (29) ovary, virgin 4-day female  26 ovary, mated 4-day female    17 testis, mated 4-day male    2 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    34 central nervous system, pupae P8    53 head, virgin 1-day female    38 head, virgin 4-day female    43 head, virgin 20-day female    50 head, mated 1-day female    28 head, mated 4-day female    44 head, mated 20-day female    43 head, mated 1-day male    50 head, mated 4-day male    64 head, mated 20-day male    75 salivary gland, larvae L3 wandering    29 salivary gland, white prepupae    38 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    10 digestive system, 4-day adult    7 digestive system, 20-day adult    6 fat body, larvae L3 wandering    48 fat body, white prepupae    59 fat body, pupae P8    14 carcass, larvae L3 wandering    17 carcass, 1-day adult    28 carcass, 4-day adult    29 carcass, 20-day adult    29 ovary, virgin 4-day female    26 ovary, mated 4-day female    17 testis, mated 4-day male    2 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    34 central nervous system, pupae P8    53 head, virgin 1-day female    38 head, virgin 4-day female    43 head, virgin 20-day female    50 head, mated 1-day female    28 head, mated 4-day female    44 head, mated 20-day female    43 head, mated 1-day male    50 head, mated 4-day male    64 head, mated 20-day male    75 salivary gland, larvae L3 wandering    29 salivary gland, white prepupae    38 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    10 digestive system, 4-day adult    7 digestive system, 20-day adult    6 fat body, larvae L3 wandering    48 fat body, white prepupae    59 fat body, pupae P8    14 carcass, larvae L3 wandering    17 carcass, 1-day adult    28 carcass, 4-day adult    29 carcass, 20-day adult    29 ovary, virgin 4-day female    26 ovary, mated 4-day female    17 testis, mated 4-day male    2 accessory gland, mated 4-day male    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    34 central nervous system, pupae P8    53 head, virgin 1-day female    38 head, virgin 4-day female    43 head, virgin 20-day female    50 head, mated 1-day female    28 head, mated 4-day female    44 head, mated 20-day female    43 head, mated 1-day male    50 head, mated 4-day male    64 head, mated 20-day male    75 salivary gland, larvae L3 wandering    29 salivary gland, white prepupae    38 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    10 digestive system, 4-day adult    7 digestive system, 20-day adult    6 fat body, larvae L3 wandering    48 fat body, white prepupae    59 fat body, pupae P8    14 carcass, larvae L3 wandering    17 carcass, 1-day adult    28 carcass, 4-day adult    29 carcass, 20-day adult    29 ovary, virgin 4-day female    26 ovary, mated 4-day female    17 testis, mated 4-day male    2 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3  (34) central nervous system, pupae P8  (53) head, virgin 1-day female  (38) head, virgin 4-day female  (43) head, virgin 20-day female  (50) head, mated 1-day female  28 head, mated 4-day female  (44) head, mated 20-day female  (43) head, mated 1-day male  (50) head, mated 4-day male  (64) head, mated 20-day male  (75) salivary gland, larvae L3 wandering  29 salivary gland, white prepupae  (38) digestive system, larvae L3 wandering    10 digestive system, 1-day adult    10 digestive system, 4-day adult    7 digestive system, 20-day adult    6 fat body, larvae L3 wandering  (48) fat body, white prepupae  (59) fat body, pupae P8    14 carcass, larvae L3 wandering    17 carcass, 1-day adult  28 carcass, 4-day adult  29 carcass, 20-day adult  29 ovary, virgin 4-day female  26 ovary, mated 4-day female    17 testis, mated 4-day male    2 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    34 central nervous system, pupae P8    53 head, virgin 1-day female    38 head, virgin 4-day female    43 head, virgin 20-day female    50 head, mated 1-day female    28 head, mated 4-day female    44 head, mated 20-day female    43 head, mated 1-day male    50 head, mated 4-day male    64 head, mated 20-day male    75 salivary gland, larvae L3 wandering    29 salivary gland, white prepupae    38 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    10 digestive system, 4-day adult    7 digestive system, 20-day adult    6 fat body, larvae L3 wandering    48 fat body, white prepupae    59 fat body, pupae P8    14 carcass, larvae L3 wandering    17 carcass, 1-day adult    28 carcass, 4-day adult    29 carcass, 20-day adult    29 ovary, virgin 4-day female    26 ovary, mated 4-day female    17 testis, mated 4-day male    2 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    34 central nervous system, pupae P8    53 head, virgin 1-day female    38 head, virgin 4-day female    43 head, virgin 20-day female    50 head, mated 1-day female    28 head, mated 4-day female    44 head, mated 20-day female    43 head, mated 1-day male    50 head, mated 4-day male    64 head, mated 20-day male    75 salivary gland, larvae L3 wandering    29 salivary gland, white prepupae    38 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    10 digestive system, 4-day adult    7 digestive system, 20-day adult    6 fat body, larvae L3 wandering    48 fat body, white prepupae    59 fat body, pupae P8    14 carcass, larvae L3 wandering    17 carcass, 1-day adult    28 carcass, 4-day adult    29 carcass, 20-day adult    29 ovary, virgin 4-day female    26 ovary, mated 4-day female    17 testis, mated 4-day male    2 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 12-18 embryonic stages, during late larval stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    20 embryo 02-04hr    8 embryo 04-06hr    20 embryo 06-08hr    29 embryo 08-10hr    38 embryo 10-12hr    44 embryo 12-14hr    56 embryo 14-16hr    19 embryo 16-18hr    39 embryo 18-20hr    22 embryo 20-22hr    19 embryo 22-24hr    33 larva L1    16 larva L2    18 larva L3 12hr old    25 larva L3 puffstage 1-2    38 larva L3 puffstage 3-6    47 larva L3 puffstage 7-9    64 white prepupae new    67 white prepupae 12hr    63 white prepupae 24hr    49 pupae 2d postWPP    43 pupae 3d postWPP    33 pupae 4d postWPP    12 adult male 01day    35 adult male 05day    25 adult male 30day    21 adult female 01day    15 adult female 05day    28 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    20 embryo 02-04hr    8 embryo 04-06hr    20 embryo 06-08hr  (29) embryo 08-10hr  (38) embryo 10-12hr  (44) embryo 12-14hr  (56) embryo 14-16hr    19 embryo 16-18hr  (39) embryo 18-20hr    22 embryo 20-22hr    19 embryo 22-24hr  (33) larva L1    16 larva L2    18 larva L3 12hr old    25 larva L3 puffstage 1-2  (38) larva L3 puffstage 3-6  (47) larva L3 puffstage 7-9  (64) white prepupae new  (67) white prepupae 12hr  (63) white prepupae 24hr  (49) pupae 2d postWPP  (43) pupae 3d postWPP  (33) pupae 4d postWPP    12 adult male 01day  (35) adult male 05day    25 adult male 30day    21 adult female 01day    15 adult female 05day  (28) adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    20 embryo 02-04hr    8 embryo 04-06hr    20 embryo 06-08hr    29 embryo 08-10hr    38 embryo 10-12hr    44 embryo 12-14hr    56 embryo 14-16hr    19 embryo 16-18hr    39 embryo 18-20hr    22 embryo 20-22hr    19 embryo 22-24hr    33 larva L1    16 larva L2    18 larva L3 12hr old    25 larva L3 puffstage 1-2    38 larva L3 puffstage 3-6    47 larva L3 puffstage 7-9    64 white prepupae new    67 white prepupae 12hr    63 white prepupae 24hr    49 pupae 2d postWPP    43 pupae 3d postWPP    33 pupae 4d postWPP    12 adult male 01day    35 adult male 05day    25 adult male 30day    21 adult female 01day    15 adult female 05day    28 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    20 embryo 02-04hr    8 embryo 04-06hr    20 embryo 06-08hr    29 embryo 08-10hr    38 embryo 10-12hr    44 embryo 12-14hr    56 embryo 14-16hr    19 embryo 16-18hr    39 embryo 18-20hr    22 embryo 20-22hr    19 embryo 22-24hr    33 larva L1    16 larva L2    18 larva L3 12hr old    25 larva L3 puffstage 1-2    38 larva L3 puffstage 3-6    47 larva L3 puffstage 7-9    64 white prepupae new    67 white prepupae 12hr    63 white prepupae 24hr    49 pupae 2d postWPP    43 pupae 3d postWPP    33 pupae 4d postWPP    12 adult male 01day    35 adult male 05day    25 adult male 30day    21 adult female 01day    15 adult female 05day    28 adult female 30day    25 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    20 embryo 02-04hr    8 embryo 04-06hr    20 embryo 06-08hr    29 embryo 08-10hr    38 embryo 10-12hr    44 embryo 12-14hr    56 embryo 14-16hr    19 embryo 16-18hr    39 embryo 18-20hr    22 embryo 20-22hr    19 embryo 22-24hr    33 larva L1    16 larva L2    18 larva L3 12hr old    25 larva L3 puffstage 1-2    38 larva L3 puffstage 3-6    47 larva L3 puffstage 7-9    64 white prepupae new    67 white prepupae 12hr    63 white prepupae 24hr    49 pupae 2d postWPP    43 pupae 3d postWPP    33 pupae 4d postWPP    12 adult male 01day    35 adult male 05day    25 adult male 30day    21 adult female 01day    15 adult female 05day    28 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    20 embryo 02-04hr    8 embryo 04-06hr    20 embryo 06-08hr  29 embryo 08-10hr  (38) embryo 10-12hr  (44) embryo 12-14hr  (56) embryo 14-16hr    19 embryo 16-18hr  (39) embryo 18-20hr    22 embryo 20-22hr    19 embryo 22-24hr  (33) larva L1    16 larva L2    18 larva L3 12hr old    25 larva L3 puffstage 1-2  (38) larva L3 puffstage 3-6  (47) larva L3 puffstage 7-9  (64) white prepupae new  (67) white prepupae 12hr  (63) white prepupae 24hr  (49) pupae 2d postWPP  (43) pupae 3d postWPP  (33) pupae 4d postWPP    12 adult male 01day  (35) adult male 05day    25 adult male 30day    21 adult female 01day    15 adult female 05day  28 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    20 embryo 02-04hr    8 embryo 04-06hr    20 embryo 06-08hr    29 embryo 08-10hr    38 embryo 10-12hr    44 embryo 12-14hr    56 embryo 14-16hr    19 embryo 16-18hr    39 embryo 18-20hr    22 embryo 20-22hr    19 embryo 22-24hr    33 larva L1    16 larva L2    18 larva L3 12hr old    25 larva L3 puffstage 1-2    38 larva L3 puffstage 3-6    47 larva L3 puffstage 7-9    64 white prepupae new    67 white prepupae 12hr    63 white prepupae 24hr    49 pupae 2d postWPP    43 pupae 3d postWPP    33 pupae 4d postWPP    12 adult male 01day    35 adult male 05day    25 adult male 30day    21 adult female 01day    15 adult female 05day    28 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    20 embryo 02-04hr    8 embryo 04-06hr    20 embryo 06-08hr    29 embryo 08-10hr    38 embryo 10-12hr    44 embryo 12-14hr    56 embryo 14-16hr    19 embryo 16-18hr    39 embryo 18-20hr    22 embryo 20-22hr    19 embryo 22-24hr    33 larva L1    16 larva L2    18 larva L3 12hr old    25 larva L3 puffstage 1-2    38 larva L3 puffstage 3-6    47 larva L3 puffstage 7-9    64 white prepupae new    67 white prepupae 12hr    63 white prepupae 24hr    49 pupae 2d postWPP    43 pupae 3d postWPP    33 pupae 4d postWPP    12 adult male 01day    35 adult male 05day    25 adult male 30day    21 adult female 01day    15 adult female 05day    28 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    21 Schneider line 2 Sg4    11 embryonic 1182-4H    8 embryonic GM2    13 embryonic Kc167    20 embryonic S1    16 embryonic S3    28 leg disc CME L1    6 wing disc CME-W2    37 wing disc ML-DmD8    28 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    10 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2    41 tumorous blood cells mbn2    24 ovary fGS/OSS    16 ovary OSC    20 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    21 Schneider line 2 Sg4    11 embryonic 1182-4H    8 embryonic GM2    13 embryonic Kc167    20 embryonic S1    16 embryonic S3  (28) leg disc CME L1    6 wing disc CME-W2  (37) wing disc ML-DmD8  (28) wing disc ML-DmD9    7 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    10 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2  (41) tumorous blood cells mbn2    24 ovary fGS/OSS    16 ovary OSC    20 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    21 Schneider line 2 Sg4    11 embryonic 1182-4H    8 embryonic GM2    13 embryonic Kc167    20 embryonic S1    16 embryonic S3    28 leg disc CME L1    6 wing disc CME-W2    37 wing disc ML-DmD8    28 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    10 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2    41 tumorous blood cells mbn2    24 ovary fGS/OSS    16 ovary OSC    20 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    21 Schneider line 2 Sg4    11 embryonic 1182-4H    8 embryonic GM2    13 embryonic Kc167    20 embryonic S1    16 embryonic S3    28 leg disc CME L1    6 wing disc CME-W2    37 wing disc ML-DmD8    28 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    10 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2    41 tumorous blood cells mbn2    24 ovary fGS/OSS    16 ovary OSC    20 ovary OSS    13 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    21 Schneider line 2 Sg4    11 embryonic 1182-4H    8 embryonic GM2    13 embryonic Kc167    20 embryonic S1    16 embryonic S3    28 leg disc CME L1    6 wing disc CME-W2    37 wing disc ML-DmD8    28 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    10 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2    41 tumorous blood cells mbn2    24 ovary fGS/OSS    16 ovary OSC    20 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    21 Schneider line 2 Sg4    11 embryonic 1182-4H    8 embryonic GM2    13 embryonic Kc167    20 embryonic S1    16 embryonic S3  28 leg disc CME L1    6 wing disc CME-W2  (37) wing disc ML-DmD8  28 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    10 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2  (41) tumorous blood cells mbn2    24 ovary fGS/OSS    16 ovary OSC    20 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    21 Schneider line 2 Sg4    11 embryonic 1182-4H    8 embryonic GM2    13 embryonic Kc167    20 embryonic S1    16 embryonic S3    28 leg disc CME L1    6 wing disc CME-W2    37 wing disc ML-DmD8    28 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    10 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2    41 tumorous blood cells mbn2    24 ovary fGS/OSS    16 ovary OSC    20 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    21 Schneider line 2 Sg4    11 embryonic 1182-4H    8 embryonic GM2    13 embryonic Kc167    20 embryonic S1    16 embryonic S3    28 leg disc CME L1    6 wing disc CME-W2    37 wing disc ML-DmD8    28 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    10 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2    41 tumorous blood cells mbn2    24 ovary fGS/OSS    16 ovary OSC    20 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    16 Cadmium 50 mM 12 hrs, larvae L3    48 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    29 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    52 Ethanol 10% 3 hrs, larvae L3    18 Caffeine 1.5 mg/ml 4 hrs, larvae L3    42 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    27 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    16 Cadmium 50 mM 12 hrs, larvae L3  (48) Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult  (29) Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult  (31) Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3  (52) Ethanol 10% 3 hrs, larvae L3    18 Caffeine 1.5 mg/ml 4 hrs, larvae L3  (42) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (29) Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult  (27) Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3  (27) Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    16 Cadmium 50 mM 12 hrs, larvae L3    48 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    29 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    52 Ethanol 10% 3 hrs, larvae L3    18 Caffeine 1.5 mg/ml 4 hrs, larvae L3    42 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    27 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    16 Cadmium 50 mM 12 hrs, larvae L3    48 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    29 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    52 Ethanol 10% 3 hrs, larvae L3    18 Caffeine 1.5 mg/ml 4 hrs, larvae L3    42 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    27 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    16 Cadmium 50 mM 12 hrs, larvae L3    48 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    29 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    52 Ethanol 10% 3 hrs, larvae L3    18 Caffeine 1.5 mg/ml 4 hrs, larvae L3    42 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    27 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    16 Cadmium 50 mM 12 hrs, larvae L3  (48) Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult  29 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult  31 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3  (52) Ethanol 10% 3 hrs, larvae L3    18 Caffeine 1.5 mg/ml 4 hrs, larvae L3  (42) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  29 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult  27 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3  27 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    16 Cadmium 50 mM 12 hrs, larvae L3    48 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    29 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    52 Ethanol 10% 3 hrs, larvae L3    18 Caffeine 1.5 mg/ml 4 hrs, larvae L3    42 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    27 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    16 Cadmium 50 mM 12 hrs, larvae L3    48 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    29 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    52 Ethanol 10% 3 hrs, larvae L3    18 Caffeine 1.5 mg/ml 4 hrs, larvae L3    42 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    27 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_25 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0016126 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1495-RH
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable CaMKIEY07197 Sterility Allele fertile CaMKIEY07197 Phenotype manifest in Allele
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of CaMKI Class Mutagen Stocks Known lesion CaMKIEY07197 P-element activity 1 -- CaMKIf00078 piggyBac transposase 1 -- CaMKIf03849 piggyBac transposase 1 --
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CaMKI Class Mutagen Stocks Known lesion CaMKIGL00274 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CaMKIGL01332 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CaMKIJF02268 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CaMKIKK109334 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CaMKIGD12690 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes CaMKINIG.1495R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(4)5-M263 (Sun et al., 2004)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12690} NA P{KK109334} NA P{NIG.1495R} NA P{TRiP.GL00274} NA P{TRiP.GL01332} NA P{TRiP.JF02268} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}CaMKIEY07197 NA miscellaneous insertions PBac{WH}CaMKIf00078 NA PBac{WH}CaMKIf03849 NA
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR017441 (FlyBase Curators et al., 2004-) calmodulin binding traceable author statement (Montell, 1999) calmodulin-dependent protein kinase activity inferred from sequence or structural similarity (Xu et al., 1998) inferred from sequence or structural similarity with Saccharomyces CMK1 (FlyBase, 1992-) protein serine/threonine kinase activity non-traceable author statement (Morrison et al., 2000)
Biological Process
CV term Evidence References
protein phosphorylation inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR008271 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Xu et al., 1998) non-traceable author statement (Morrison et al., 2000)
Cellular Component
CV term Evidence References
cytosol inferred from sequence or structural similarity (Picciotto et al., 1995)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CaMKI allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0016126 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43792 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q0KIF7
Orthologs
OrthoDB Orthologs (115) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG618C79 Dipteran inclusive ortholog search EOG6HX58M Insect inclusive ortholog search EOG68GTZR Arthropod inclusive ortholog search EOG6D7WN4 Metazoa inclusive ortholog search EOG6SBSRM
Orthologs in Drosophila Species (EOG618C79)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CaMKI     Drosophila simulans   Dsim\GD24788 Y   Drosophila sechellia   Dsec\GM26797 Y   Drosophila erecta   Dere\GG16388 Y   Drosophila yakuba   Dyak\CaMKI Y   Drosophila ananassae   Dana\GF22801 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA13377 Y   Drosophila persimilis   Dper\GL18141 Y   Drosophila willistoni   Dwil\GK13601 Y   Drosophila virilis   Dvir\GJ19665 Y   Drosophila mojavensis   Dmoj\GI14047 Y   Drosophila grimshawi   Dgri\GH24012 Y
Orthologs in non-Drosophila Dipterans (EOG6HX58M)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL011441   Anopheles gambiae Malaria mosquito  Agam\AGAP005306   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ018980
Orthologs in non-Dipteran Insects (EOG68GTZR)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB46266   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG016557   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH11563   Atta cephalotes Leafcutter ant  Acep\ACEP13125   Atta cephalotes Leafcutter ant  Acep\ACEP13121   Camponotus floridanus Florida carpenter ant  Cflo\CFLO17265   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL20513   Linepithema humile Argentine ant  Lhum\LH25068   Pogonomyrmex barbatus Red harvester ant  Pbar\PB21603   Solenopsis invicta Red fire ant  Sinv\SINV23998   Acyrthosiphon pisum Pea aphid  Apim\ACYPI007716   Bombyx mori Silkmoth  Bmor\BGIBMGA010572   Pediculus humanus Human body louse  Phum\PHUM596220   Tribolium castaneum Red flour beetle  Tcas\TC004142
Orthologs in non-Insect Arthropods (EOG6D7WN4)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Vmo1   Ixodes scapularis Deer tick  Isca\ISCW002105
Orthologs in non-Arthropod Metazoa (EOG6SBSRM)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\cmk-1 Y Caenorhabditis elegans Nematode  Cele\zyg-8 Y Caenorhabditis elegans Nematode  Cele\R06A10.4 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_023309gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024395gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_009878gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024394gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_013604gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_003844gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_002105gn Y Danio rerio Zebrafish  Drer\camk4 Y Danio rerio Zebrafish  Drer\ENSDARG00000060116 Y Danio rerio Zebrafish  Drer\pskh1 Y Danio rerio Zebrafish  Drer\camkvl Y Danio rerio Zebrafish  Drer\zgc:171845 Y Danio rerio Zebrafish  Drer\ENSDARG00000008788 Y Danio rerio Zebrafish  Drer\camkv Y Danio rerio Zebrafish  Drer\dclk2 Y Danio rerio Zebrafish  Drer\ENSDARG00000027963 Y Danio rerio Zebrafish  Drer\ENSDARG00000079882 Y Danio rerio Zebrafish  Drer\camk1g Y Danio rerio Zebrafish  Drer\ENSDARG00000078504 Y Danio rerio Zebrafish  Drer\dclk1 Y Danio rerio Zebrafish  Drer\camk1d Y Danio rerio Zebrafish  Drer\BX005047.1 Y Danio rerio Zebrafish  Drer\BX571768.1 Y Danio rerio Zebrafish  Drer\ENSDARG00000074905 Y Danio rerio Zebrafish  Drer\pnck Y Danio rerio Zebrafish  Drer\ENSDARG00000024936 Y Xenopus tropicalis Western clawed frog  Xtro\pskh1 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000003272 Y Xenopus tropicalis Western clawed frog  Xtro\camk1g Y Xenopus tropicalis Western clawed frog  Xtro\dclk2 Y Xenopus tropicalis Western clawed frog  Xtro\dclk3 Y Xenopus tropicalis Western clawed frog  Xtro\pskh2 Y Xenopus tropicalis Western clawed frog  Xtro\camkv Y Xenopus tropicalis Western clawed frog  Xtro\camk4 Y Xenopus tropicalis Western clawed frog  Xtro\camk1d Y Xenopus tropicalis Western clawed frog  Xtro\dcx Y Xenopus tropicalis Western clawed frog  Xtro\pnck Y Xenopus tropicalis Western clawed frog  Xtro\dclk1 Y Xenopus tropicalis Western clawed frog  Xtro\camk1 Y Gallus gallus Domestic chicken  Ggal\CAMK4 Y Gallus gallus Domestic chicken  Ggal\PSKH1 Y Gallus gallus Domestic chicken  Ggal\DCLK1 Y Gallus gallus Domestic chicken  Ggal\CAMK1D Y Gallus gallus Domestic chicken  Ggal\DCLK2 Y Gallus gallus Domestic chicken  Ggal\LOC415928 Y Gallus gallus Domestic chicken  Ggal\DCX Y Gallus gallus Domestic chicken  Ggal\CAMK1G Y Gallus gallus Domestic chicken  Ggal\DCLK3 Y Mus musculus House mouse  Mmus\Camkv Y Mus musculus House mouse  Mmus\Dcx Y Mus musculus House mouse  Mmus\Pskh1 Y Mus musculus House mouse  Mmus\Dclk1 Y Mus musculus House mouse  Mmus\ENSMUSG00000028078 Y Mus musculus House mouse  Mmus\Dclk3 Y Mus musculus House mouse  Mmus\Pnck Y Mus musculus House mouse  Mmus\Camk1 Y Mus musculus House mouse  Mmus\Camk1g Y Mus musculus House mouse  Mmus\Camk1d Y Rattus norvegicus Norway rat  Rnor\Dclk3 Y Rattus norvegicus Norway rat  Rnor\Dclk1 Y Rattus norvegicus Norway rat  Rnor\Camk4 Y Rattus norvegicus Norway rat  Rnor\Dclk2 Y Rattus norvegicus Norway rat  Rnor\Pnck Y Rattus norvegicus Norway rat  Rnor\RGD1560691 Y Rattus norvegicus Norway rat  Rnor\Camkv Y Rattus norvegicus Norway rat  Rnor\Camk1 Y Rattus norvegicus Norway rat  Rnor\Dcx Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000043408 Y Rattus norvegicus Norway rat  Rnor\Camk1g Y Homo sapiens Human  Hsap\PSKH2 Y Homo sapiens Human  Hsap\DCX Y Homo sapiens Human  Hsap\DCLK2 Y Homo sapiens Human  Hsap\CAMK1 Y Homo sapiens Human  Hsap\CAMK1G Y Homo sapiens Human  Hsap\CAMK1D Y Homo sapiens Human  Hsap\ENSG00000133083 Y Homo sapiens Human  Hsap\CAMK4 Y Homo sapiens Human  Hsap\PSKH1 Y Homo sapiens Human  Hsap\PNCK Y Homo sapiens Human  Hsap\DCLK3 Y Homo sapiens Human  Hsap\CAMKV Y
Human Orthologs (12)
Gene OMIM HGNC Hsap\PSKH2     Hsap\DCX     Hsap\DCLK2     Hsap\CAMK1     Hsap\CAMK1G     Hsap\CAMK1D     Hsap\ENSG00000133083     Hsap\CAMK4     Hsap\PSKH1     Hsap\PNCK     Hsap\DCLK3     Hsap\CAMKV
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD24788 Drosophila sechellia Dsec\GM26797 Drosophila erecta Dere\GG16388 Drosophila yakuba Dyak\CaMKI Drosophila ananassae Dana\GF22801 Drosophila pseudoobscura pseudoobscura Dpse\GA13377 Drosophila persimilis Dper\GL18141 Drosophila willistoni Dwil\GK13601 Drosophila virilis Dvir\GJ19665 Drosophila mojavensis Dmoj\GI14047 Drosophila grimshawi Dgri\GH24012
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	26726 y1 v1; P{TRiP.JF02268}attP2 16799 y1 w67c23; P{EPgy2}CaMKIEY07197 35362 y1 sc* v1; P{TRiP.GL00274}attP2 41900 y1 sc* v1; P{TRiP.GL01332}attP2
Harvard	- PBac{WH}CaMKIf00078 - PBac{WH}CaMKIf03849
VDRC	v101380 P{KK109334}VIE-260B
Genomic Clones ( 1 )
	BACR30L17 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 267 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH04968 RE12039 RE39750
Other clones	yak-em_CaMKI
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH01068 GH23134 GH23448 GH28695 HL01883 HL02963 HL02964 LD18375 LD18887 LD20805 LP11667 LP16791 LP21548 RE03741 RE03788 RE05109 RE07471 RE22044 RE26053 RE28617 RE28964 RE29309 RE29436 RE35122 RE36131 RE37834 RE44905 RE47977 RE57467 RE65861 RE68554 RE70541 RE72181 RH40066
Other clones	149 6980 8523 10463 12632 14543 14929 28527 30379 35354 35463 35766 45038 54938 62085 62099 63223 65194 66258 73632 73975 76084 79192 104096 104315 109131 117355 117649 120625 120708 123403 144318 146965 158929 160138 174163 175862 177804 194048 194213 214247.12 214257.14 214341.12 214441.18 214539.11 214571.11 214571.12 272666 282751 283739 CK01.3C.E6 CK01.13B.C4 CK01.61C.C6 CK01.64D.H2 CK01.79A.G5 CK01.88C.G8 CK01.100D.C3 CK01.102C.E2 CK01.110C.B12 CK01.123D.D11 CK01.124B.C8 CK01.132A.D3 CK01.168A.E5 CK01.169B.E3 EC12101 EC13110 EC17361 EC28642 EC28839 EC29801 EC33440 EC35950 EC43501 EC051526 EC051528 EC052522 EC053518 EC055003 EC055358 EC056104 EK005102 EK014242 EK038806 EK048543 EK051009 EK065261 EK069710 EK069760 EK077510 EK083730 EK085110 EK094544 EK098107 EK102730 EK102915 EK103818 EK105246 EK110633 EK113453 EK117613 EK118002 EK118317 EK125313 EK132308 EK138438 EK146038 EK146332 EK153706 EK159605 EK160647 EK164262 EK181751 EK187420 EK187459 EK191414 EK193755 EK197350 EK202515 EK204033 EK245112 EK246226 EK249535 EK250637 EK261853 EK280157 EK282660 EK291046 EK296405 EK297016 EK308637 EK309245 EP07832 EP08543 EP10416 EP11564 EP15348 EP16715 ESG013c.E21_C07 ESG014d.E21_E02 ESG015d.E21.1_D05 ESG0111c.B21.1_H08 ESG0114c.B21_B08 ESG0115c.B21_C07 GH06288 GH14309 RP003001323 RP003032396 RP003042986 RP003063980 RP003066571 RP003071107 RP003074900 RP003075773 RP003080992 RP003085681 RP003093266 RP003114740 RP003124243 RP003125427 RP003127268 RP003131078 RP003140932 RP003144109 RP003146660 RP003157883 RP003175407 RP003184349 RP003193080 RP003200939 RP003203191 RP003203355 RP003210511 RP003218424 RP003226436 RP003229509 RP003230170 RP003258466 RP003260486 RP003270390 RP003278665 RP003280632 RP003283205 RP003285969 RP003291860 RP003295043 RP003296468 RP003303550 RP003317261 RP003318442 RP003320641 RP003338060 RP003344586 RP003355842 RP003373941 RP003396357 RP003398291 RP003399098 RP003403196 RP003417901 RP003428229 RP003450142 RP003457881 RP003467993 RP003474040 RP003483682 RP003484579 RP003486188 RP003497224 RP003501967 RP003510858 RP003514337 RP003522283 RP003546848 RP003559392 RP003562632 RP003564256 RP003564994 RP003574951 RP003578705 RP003582693 RP003596660 RP003611267 RP003627742 RP003632716 RP003638511 RP003641164 RP003657251 RP003668028 UUGC1027
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0016126 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43792
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: CaMKI CG1495 (Milshina, 1999.11)
Source for database merge of
Additional comments
Other Comments
	Identification: Cam-binding protein that is expressed in the retina. (Xu et al., 1998) CaM-kinase I has been detected by Western blotting in extracts using an antibody against the rat protein. (Picciotto et al., 1995)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079883 NM_166759 NM_166760 NM_166761 NM_166764 RefSeq (Proteins) • NP_524622 NP_726569 NP_726570 NP_726571 NP_726574 DDBJ / EMBL / GenBank • AAF59343 AAF59344 AAN06531 AAN06532 AAN06533 AAN06534 AAN06535 AAN71308 AAN71392 AAO25071 AC012390 AI064519 AW940186 BI170540 BI242426 BT001553 BT001637 BT003311 CAA76937 CL527989 CZ482564 CZ486445 CZ486446 Y17917 Entrez Gene - A searchable database of RefSeq genes. • 43792 UniProtKB/TrEMBL • Q0KIF7 Q7JMV3 Q8IGW6 Q86P88
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine- / dual specificity protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Calcium/calmodulin-dependent/calcium-dependent protein kinase (IPR020636)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0016126 DRSC - Results from RNAi screens. • FBgn0016126 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0016126 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1495-RH FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0016126 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43792 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43792 modMine - Data generated by the modENCODE project. • FBgn0016126 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q0KIF7
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	Calcium/calmodulin-dependent protein kinase (Morley and Montgomery, 2001) caMKI (Bartolome and Maside, 2004) CamKI (Jasper et al., 2002) camKI (Locke et al., 2000) CaMKI (Riddle et al., 2008, Hartmann et al., 2011, Japanese National Institute of Genetics, 2012.5.21) CG1495 (Morrison et al., 2000, Perkins et al., 2009.3.31, Keleman et al., 2009.8.5, Ni et al., 2011.7.19, Ni et al., 2010.12.1) dCKI (Xu et al., 1998)
Name Synonym	Calcium/calmodulin-dependent protein kinase I   calmodulin-dependent kinase (Harris and Lim, 2001)
Secondary FlyBase IDs
References ( 40 )
Generate a list of	All references relating to this gene ( 40 )
List References by type	Research paper  ( 15 ) Supplementary material  ( 5 ) Review  ( 3 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 2 ) FlyBase analysis  ( 1 ) Stock list  ( 1 ) Curated genome annotation  ( 3 ) DNA/RNA sequence record  ( 1 )
Recent research papers ( 2 )
	Ambegaokar and Jackson, 2011, Hum. Mol. Genet. 20(24): 4947--4977 Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation. [FBrf0217690] Hartmann et al., 2011, RNA 17(3): 453--468 Distinct regulatory programs establish widespread sex-specific alternative splicing in Drosophila melanogaster. [FBrf0212988] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...