Gene Dins\Adh

Help Close All Open All

General Information

Symbol

Dins\Adh

Species

D. insularis

Name

Adh

Annotation symbol

Feature type

gene

FlyBase ID

FBgn0016214

Gene Model Status

Unannotated

Stock availability

None publicly available

Also Known As

Adh

Genomic Location

Chromosome (arm)

Recombination map

2R-

Cytogenetic map

Sequence location

Summary Information

Automatically generated summary

See sections below for more information

The gene Adh is referred to in FlyBase by the symbol Dins\Adh (FBgn0016214). It is a gene from Drosophila insularis. Based on sequence similarity, it is predicted to have molecular function: alcohol dehydrogenase (NAD) activity. Based on sequence similarity, it is predicted to be involved in the biological process: alcohol catabolic process. No alleles are reported. It has no annotated transcripts. Protein features are: Alcohol dehydrogenase, Drosophila-type; Alcohol dehydrogenase, insect-type; NAD(P)-binding domain; Short-chain dehydrogenase/reductase SDR; Short-chain dehydrogenase/reductase, conserved site. Gene has not been localized to the genome sequence.

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

Update Feed

Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.

FB2013_03

FB2013_02

All updates

Click here to see a list of all updates to this record from FB2010_08 and on.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Located using a D.melanogaster probe.

(Rohde et al., 1995)

Experimentally Determined Recombination Data

Location

2R-

(Rohde et al., 1995)

2- [right arm]

(Griffith, 1997.3.27)

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Short-chain dehydrogenase/reductase SDR (IPR002198)

Alcohol dehydrogenase, insect-type (IPR002424)

Alcohol dehydrogenase, Drosophila-type (IPR002425)

NAD(P)-binding domain (IPR016040)

Short-chain dehydrogenase/reductase, conserved site (IPR020904)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Q9NG40

UniProtKB/TrEMBL

Mapped Features

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization (GO Cellular Component)

CV term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

modENCODE Anatomy RNA-Seq

modENCODE Development RNA-Seq

modENCODE Cell Lines RNA-Seq

modENCODE Treatments RNA-Seq

Expression Clusters

External Data & Images

Linkouts

Alleles & Phenotypes

Summary of Allele Phenotypes

Phenotype manifest in

Allele

Classical Alleles ( 0 )

For All Classical Alleles Show

Allele of Dins\Adh	Class	Mutagen	Stocks	Known lesion

Alleles Carried on Transgenic Constructs ( 0 )

For All Alleles Carried on Transgenic Constructs Show

Allele of Dins\Adh	Class	Mutagen	Stocks	Known lesion

Aneuploid Aberrations

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

Insertions

Type of insertions

Name

Expression data

Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )

There is no information supporting a cellular component term for this gene.

(Based on a review of available data before: 2006)

Terms Based on Experimental Evidence ( 0 terms )

Terms Based on Predictions or Assertions ( 3 terms )

Molecular Function

CV term

Evidence

References

alcohol dehydrogenase (NAD) activity

inferred from sequence or structural similarity with UniProtKB:P00334

(Swiss-Prot Project Members, 2004.3.29)

Biological Process

CV term

Evidence

References

alcohol catabolic process

inferred from sequence or structural similarity with UniProtKB:P00334

(Swiss-Prot Project Members, 2004.3.29)

oxidation-reduction process

inferred from electronic annotation with InterPro:IPR002424, InterPro:IPR002425

(FlyBase Curators et al., 2004-)

Cellular Component ( 0 terms)

Sequence Ontology: Class of Gene

gene

Interactions & Pathways

Summary of Physical Interactions

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

Dins\Adh allele

Gene

References

External Data

Linkouts

Orthologs

OrthoDB Orthologs (0) - based on analysis using Dmel annotation version 5.41

OrthoDB Ortholog Groups

OrthoDB orthology group searches

(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)

Drosophila inclusive ortholog search

No orthologs identified

Dipteran inclusive ortholog search

No orthologs identified

Insect inclusive ortholog search

No orthologs identified

Arthropod inclusive ortholog search

No orthologs identified

Metazoa inclusive ortholog search

No orthologs identified

Ortholog(s) in Drosophila melanogaster (None identified)

No D. melanogaster orthologies identified

Human Orthologs (0)

Gene

OMIM

HGNC

AAA Orthologs (0) based on analysis using Dmel annotation version 4.3

No orthologs identified

Stocks & Reagents

Stocks Listed in FlyBase ( 0 )

Genomic Clones ( 0 )

cDNA Clones ( 0 )

cDNA Clones, Fully Sequenced

BDGP DGC clones

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Linkouts

Antibody Information

Other Information

Discoverer

Etymology

Identification

Relationship to Other Genes

Source for database identity of

Source for database merge of

Additional comments

Other Comments

External Crossreferences & Linkouts

Sequence Crossreferences

DDBJ / EMBL / GenBank

•

UniProtKB/Swiss-Prot

•

Q9NG40

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Short-chain dehydrogenase/reductase SDR (IPR002198)

Alcohol dehydrogenase, insect-type (IPR002424)

Alcohol dehydrogenase, Drosophila-type (IPR002425)

NAD(P)-binding domain (IPR016040)

Short-chain dehydrogenase/reductase, conserved site (IPR020904)

Linkouts

Synonyms & Secondary IDs ( 2 )

Reported As

Symbol Synonym

Adh

(Robe et al., 2010, Powell et al., 2011)

Dins\Adh

Name Synonym

Adh

Secondary FlyBase IDs

References ( 12 )

Research paper

Powell et al., 2011, Mol. Biol. Evol. 28(1): 825--833: Nonrecombining genes in a recombination environment: the Drosophila "dot" chromosome. [FBrf0212577]
Robe et al., 2010, Genetica 138(6): 601--617: Taxonomic boundaries, phylogenetic relationships and biogeography of the Drosophila willistoni subgroup (Diptera: Drosophilidae). [FBrf0210636]
Jones and Begun, 2005, Proc. Natl. Acad. Sci. U.S.A. 102(32): 11373--11378: Parallel evolution of chimeric fusion genes. [FBrf0188260]
Rodriguez-Trelles et al., 2000, J. Mol. Evol. 50(1): 1--10: Fluctuating mutation bias and the evolution of base composition in Drosophila. [FBrf0125114]
Silva and Kidwell, 2000, Mol. Biol. Evol. 17(10): 1542--1557: Horizontal transfer and selection in the evolution of P elements. [FBrf0130287]
Gleason et al., 1998, Evolution 52(4): 1093--1103: A molecular phylogeny of the Drosophila willistoni group: Conflicts between species concepts? [FBrf0104630]
Rohde et al., 1995, Cytobios 81(324): 37--47: Analysis and in situ mapping of the Adh locus in species of the willistoni group of Drosophila. [FBrf0083397]

Personal communication to FlyBase

FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms.: Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]

FlyBase analysis

FlyBase Curators, 2002-, Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase.: Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. [FBrf0159398]

DNA/RNA sequence record

Griffith, 1997.3.27, GenBank/EMBL/DDBJ: U95273: Drosophila insularis FA alcohol dehydrogenase (Adh) gene, complete cds. [FBrf0115443]

Protein sequence record

Swiss-Prot Project Members, 2004.3.29, UniProtKB: Q9NG40: Alcohol dehydrogenase (EC 1.1.1.1). [FBrf0178316]

Thesis

O'Grady, 1998, Ph.D. Thesis, University of Arizona, AZ: 223pp: Phylogenetic relationships of files in the family Drosophilidae inferred by combined analysis of molecular and morphological data sets. [FBrf0110450]