• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\Nlp

General Information
Symbol	Dmel\Nlp	Species	D. melanogaster
Name	Nucleoplasmin	Annotation symbol	CG7917
Feature type	protein_coding_gene	FlyBase ID	FBgn0016685
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	dNLP, CRP1
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	99D1-99D1	Sequence location	3R:25,830,507..25,836,074 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Nucleoplasmin is referred to in FlyBase by the symbol Dmel\Nlp (CG7917, FBgn0016685). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: histone binding; ATPase activity, coupled. It is reported to be involved in the biological process: nucleosome positioning. 7 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Nucleoplasmin; Nucleoplasmin core domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the larval period, during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system, adult testis, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1635608_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Nlp. Gene sequence location is 3R:25830507..25836074.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 99D1-99D1   Limits computationally determined from genome sequence between P{PZ}ncd05884 and P{lacW}l(3)s2500s2500
Experimentally Determined Cytological Location
Cytogenetic map Notes References 99A-99A   (determined by in situ hybridisation)   (Crevel et al., 1997)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Nlp for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Nlp-RA FBtr0085552  NM_079833   1080   152 Nlp-RB FBtr0334701  NM_001276165   914   152
Additional Transcript Data & Comments
Reported size (kB)	1.2 (northern blot) (Ito et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Nlp-PA   FBpp0084918   17.0   152   4.24     NP_524557   AAF56988 Nlp-PB   FBpp0306756   17.0   152   4.24     NP_001263094   AGB96473
Additional Polypeptide Data & Comments
Reported size (kDa)	152 (aa); 16.977 (kD predicted) (Crevel et al., 1997) 152, 121 (aa); 22 (kD observed); 16.985, 15.522 (kD predicted) (Ito et al., 1996)
Comments	In in vitro assays, purified native or recombinant Nlp protein coimmunoprecipitates with core histones. In a reaction containing DNA, purified core histones, ATP and partially purified CAF1 fraction, the longer Nlp protein was able to promote assembly of approximately regularly spaced nucleosome arrays, while the shorter Nlp protein could not. When Nap1 and Nlp proteins were compared, only Nap1 was able to promote sperm decondensation in Xenopus laevis sperm chromatin (contrast this with the results of FBrf0093082). (Crevel et al., 1997) The shorter Nlp protein lacks 31 N-terminal residues found in the longer protein; this deletion abolishes the specificity of interaction with core histones. (Ito et al., 1996)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Nucleoplasmin (IPR004301) Nucleoplasmin core domain (IPR024057) PDB - Protein Data Bank. An information portal to biological macromolecular structures • 1NLQ
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201436   AA263235   AA263758   AA264010   AA392455   AA440130   AA441499   AA695428   AA696695   AA803325   AA942103   AA951081   AA951807   AE014297 AAF56988   AE014297 AGB96473   AI134906   AI259860   AI293224   AI518524   AI532761   AI533788   AI543919   AI546446   AQ073010   AW942420   AY119592 AAM50246   BE975379   BE978189   BG633872   BG635283   BG639053   BG641226   BI167580   BI230134   BI231572   BI231761   BI235131   BI236469   BI242915   BI351681   BI352748   BI352858   BI569689   BI570329   BI579026   BI609327   BI620231   BI620739   BI633813   BI635203   BP550009   BP550010   BP551301   BP551302   BP554992   BQ103171   CO177049   CO179232   CO188330   CO189048   CO190742   CO191571   CO192698   CO278968   CO287155   CO289578   CO290055   CO295813   CO295872   CO297800   CO300922   CO303386   CO309212   CO341312   CO341406   EC058231   EC062679   EC066350   EC075544   EC075591   EC195910   EC198779   EC206851   EC219136   EC219850   EC226050   EC228966   EC230145   EC245770   EC247432   EC259364   EL886127   EL887255   EV575623   EV576353   EV577572   EV577740   EV578946   EV580469   EV581360   EV581405   EV581811   EV582537   EV583316   EV583468   EV585400   EV586146   EV588596   EV588856   EV590579   EV590639   EV593107   EV596186   EV597065   EV597687   EV600306   GH793222   GH796596   GH830766   GH851969   GH899833   GH910239   U59497   U59498 AAC47295   X99293 CAA67679
UniProtKB/Swiss-Prot	Q27415
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Crevel et al., 1997) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011) western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Ito et al., 1996)
Additional Descriptive Data
	Nlp protein localizes to nuclei of Schneider cells and of Drosophila embryos. (Ito et al., 1996) Nlp protein localizes to nuclei of Schneider cells and of Drosophila embryos. (Ito et al., 1996)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
nucleolus inferred from direct assay (Colflesh et al., 1999) nucleus inferred from direct assay (Colflesh et al., 1999, Ito et al., 1996)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system, adult testis, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    2025.95 Larval Midgut    696.1 Larval Hindgut    1447.4 Larval Malpighian Tubules    1537.4 Larval Fat Body    660 Larval Salivary Gland    2606.5 Larval Trachea    2149.3 Larval Carcass    1193.1 Adult Head    537.2 Adult Eye    559.925 Adult Brain    448.3 Adult Thoracic-Abdominal Ganglion    485.2 Adult Crop    725.1 Adult Midgut    753.6 Adult Hindgut    612.3 Adult Malpighian Tubules    1281.6 Adult Fat Body    880.3 Adult Salivary Gland    894.8 Adult Heart    637.7 Adult VirginFemale Spermatheca    1167.6 Adult InseminatedFemale Spermatheca    1462.6 Adult Ovary    2115.8 Adult Testis    398.3 Adult Male Accessory Gland    2063.2 Adult Carcass    483.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (2025.95) Larval Midgut  (696.1) Larval Hindgut  (1447.4) Larval Malpighian Tubules  (1537.4) Larval Fat Body  (660) Larval Salivary Gland  (2606.5) Larval Trachea  (2149.3) Larval Carcass  (1193.1) Adult Head  537.2 Adult Eye  (559.925) Adult Brain    448.3 Adult Thoracic-Abdominal Ganglion    485.2 Adult Crop  (725.1) Adult Midgut  (753.6) Adult Hindgut  (612.3) Adult Malpighian Tubules  (1281.6) Adult Fat Body  (880.3) Adult Salivary Gland  (894.8) Adult Heart  (637.7) Adult VirginFemale Spermatheca  (1167.6) Adult InseminatedFemale Spermatheca  (1462.6) Adult Ovary  (2115.8) Adult Testis    398.3 Adult Male Accessory Gland  (2063.2) Adult Carcass    483.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (2025.95) Larval Midgut    696.1 Larval Hindgut  (1447.4) Larval Malpighian Tubules  (1537.4) Larval Fat Body    660 Larval Salivary Gland  (2606.5) Larval Trachea  (2149.3) Larval Carcass  (1193.1) Adult Head    537.2 Adult Eye    559.925 Adult Brain    448.3 Adult Thoracic-Abdominal Ganglion    485.2 Adult Crop    725.1 Adult Midgut    753.6 Adult Hindgut    612.3 Adult Malpighian Tubules  (1281.6) Adult Fat Body    880.3 Adult Salivary Gland    894.8 Adult Heart    637.7 Adult VirginFemale Spermatheca  (1167.6) Adult InseminatedFemale Spermatheca  (1462.6) Adult Ovary  (2115.8) Adult Testis    398.3 Adult Male Accessory Gland  (2063.2) Adult Carcass    483.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2025.95 Larval Midgut    696.1 Larval Hindgut    1447.4 Larval Malpighian Tubules    1537.4 Larval Fat Body    660 Larval Salivary Gland    2606.5 Larval Trachea    2149.3 Larval Carcass    1193.1 Adult Head    537.2 Adult Eye    559.925 Adult Brain    448.3 Adult Thoracic-Abdominal Ganglion    485.2 Adult Crop    725.1 Adult Midgut    753.6 Adult Hindgut    612.3 Adult Malpighian Tubules    1281.6 Adult Fat Body    880.3 Adult Salivary Gland    894.8 Adult Heart    637.7 Adult VirginFemale Spermatheca    1167.6 Adult InseminatedFemale Spermatheca    1462.6 Adult Ovary    2115.8 Adult Testis    398.3 Adult Male Accessory Gland    2063.2 Adult Carcass    483.3 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    2025.95 Larval Midgut    696.1 Larval Hindgut    1447.4 Larval Malpighian Tubules    1537.4 Larval Fat Body    660 Larval Salivary Gland    2606.5 Larval Trachea    2149.3 Larval Carcass    1193.1 Adult Head    537.2 Adult Eye    559.925 Adult Brain    448.3 Adult Thoracic-Abdominal Ganglion    485.2 Adult Crop    725.1 Adult Midgut    753.6 Adult Hindgut    612.3 Adult Malpighian Tubules    1281.6 Adult Fat Body    880.3 Adult Salivary Gland    894.8 Adult Heart    637.7 Adult VirginFemale Spermatheca    1167.6 Adult InseminatedFemale Spermatheca    1462.6 Adult Ovary    2115.8 Adult Testis    398.3 Adult Male Accessory Gland    2063.2 Adult Carcass    483.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (2025.95) Larval Midgut  696.1 Larval Hindgut  (1447.4) Larval Malpighian Tubules  (1537.4) Larval Fat Body  660 Larval Salivary Gland  (2606.5) Larval Trachea  (2149.3) Larval Carcass  (1193.1) Adult Head  537.2 Adult Eye  559.925 Adult Brain    448.3 Adult Thoracic-Abdominal Ganglion    485.2 Adult Crop  725.1 Adult Midgut  753.6 Adult Hindgut  612.3 Adult Malpighian Tubules  (1281.6) Adult Fat Body  (880.3) Adult Salivary Gland  (894.8) Adult Heart  637.7 Adult VirginFemale Spermatheca  (1167.6) Adult InseminatedFemale Spermatheca  (1462.6) Adult Ovary  (2115.8) Adult Testis    398.3 Adult Male Accessory Gland  (2063.2) Adult Carcass    483.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (2025.95) Larval Midgut    696.1 Larval Hindgut  1447.4 Larval Malpighian Tubules  1537.4 Larval Fat Body    660 Larval Salivary Gland  (2606.5) Larval Trachea  (2149.3) Larval Carcass  1193.1 Adult Head    537.2 Adult Eye    559.925 Adult Brain    448.3 Adult Thoracic-Abdominal Ganglion    485.2 Adult Crop    725.1 Adult Midgut    753.6 Adult Hindgut    612.3 Adult Malpighian Tubules  1281.6 Adult Fat Body    880.3 Adult Salivary Gland    894.8 Adult Heart    637.7 Adult VirginFemale Spermatheca  1167.6 Adult InseminatedFemale Spermatheca  1462.6 Adult Ovary  (2115.8) Adult Testis    398.3 Adult Male Accessory Gland  (2063.2) Adult Carcass    483.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2025.95 Larval Midgut    696.1 Larval Hindgut    1447.4 Larval Malpighian Tubules    1537.4 Larval Fat Body    660 Larval Salivary Gland    2606.5 Larval Trachea    2149.3 Larval Carcass    1193.1 Adult Head    537.2 Adult Eye    559.925 Adult Brain    448.3 Adult Thoracic-Abdominal Ganglion    485.2 Adult Crop    725.1 Adult Midgut    753.6 Adult Hindgut    612.3 Adult Malpighian Tubules    1281.6 Adult Fat Body    880.3 Adult Salivary Gland    894.8 Adult Heart    637.7 Adult VirginFemale Spermatheca    1167.6 Adult InseminatedFemale Spermatheca    1462.6 Adult Ovary    2115.8 Adult Testis    398.3 Adult Male Accessory Gland    2063.2 Adult Carcass    483.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    537.2   NA  Eye    559.925   NA  Brain    448.3   2025.95  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    485.2   NA  Crop    725.1   696.1  Midgut    753.6   1447.4  Hindgut    612.3   1537.4  Malpighian Tubules    1281.6   660  Fat Body    880.3   2606.5  Salivary Gland    894.8   NA  Heart    637.7   2149.3  Trachea    NA   NA  VirginFemale Spermatheca    1167.6   NA  InseminatedFemale Spermatheca    1462.6   NA  Ovary    2115.8   NA  Testis    398.3   NA  Male Accessory Gland    2063.2   1193.1  Carcass    483.3 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    588 central nervous system, larvae L3    861 central nervous system, pupae P8    189 head, virgin 1-day female    87 head, virgin 4-day female    87 head, virgin 20-day female    56 head, mated 1-day female    73 head, mated 4-day female    120 head, mated 20-day female    60 head, mated 1-day male    49 head, mated 4-day male    112 head, mated 20-day male    96 salivary gland, larvae L3 wandering    45 salivary gland, white prepupae    63 digestive system, larvae L3 wandering    195 digestive system, 1-day adult    103 digestive system, 4-day adult    231 digestive system, 20-day adult    112 fat body, larvae L3 wandering    65 fat body, white prepupae    124 fat body, pupae P8    272 carcass, larvae L3 wandering    464 carcass, 1-day adult    86 carcass, 4-day adult    193 carcass, 20-day adult    104 ovary, virgin 4-day female    845 ovary, mated 4-day female    863 testis, mated 4-day male    187 accessory gland, mated 4-day male    135 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (588) central nervous system, larvae L3  (861) central nervous system, pupae P8  (189) head, virgin 1-day female  (87) head, virgin 4-day female  (87) head, virgin 20-day female  (56) head, mated 1-day female  (73) head, mated 4-day female  (120) head, mated 20-day female  (60) head, mated 1-day male  (49) head, mated 4-day male  (112) head, mated 20-day male  (96) salivary gland, larvae L3 wandering  (45) salivary gland, white prepupae  (63) digestive system, larvae L3 wandering  (195) digestive system, 1-day adult  (103) digestive system, 4-day adult  (231) digestive system, 20-day adult  (112) fat body, larvae L3 wandering  (65) fat body, white prepupae  (124) fat body, pupae P8  (272) carcass, larvae L3 wandering  (464) carcass, 1-day adult  (86) carcass, 4-day adult  (193) carcass, 20-day adult  (104) ovary, virgin 4-day female  (845) ovary, mated 4-day female  (863) testis, mated 4-day male  (187) accessory gland, mated 4-day male  (135) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (588) central nervous system, larvae L3  (861) central nervous system, pupae P8  (189) head, virgin 1-day female    87 head, virgin 4-day female    87 head, virgin 20-day female    56 head, mated 1-day female    73 head, mated 4-day female  (120) head, mated 20-day female    60 head, mated 1-day male    49 head, mated 4-day male  (112) head, mated 20-day male    96 salivary gland, larvae L3 wandering    45 salivary gland, white prepupae    63 digestive system, larvae L3 wandering  (195) digestive system, 1-day adult  103 digestive system, 4-day adult  (231) digestive system, 20-day adult  (112) fat body, larvae L3 wandering    65 fat body, white prepupae  (124) fat body, pupae P8  (272) carcass, larvae L3 wandering  (464) carcass, 1-day adult    86 carcass, 4-day adult  (193) carcass, 20-day adult  104 ovary, virgin 4-day female  (845) ovary, mated 4-day female  (863) testis, mated 4-day male  (187) accessory gland, mated 4-day male  (135) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    588 central nervous system, larvae L3    861 central nervous system, pupae P8    189 head, virgin 1-day female    87 head, virgin 4-day female    87 head, virgin 20-day female    56 head, mated 1-day female    73 head, mated 4-day female    120 head, mated 20-day female    60 head, mated 1-day male    49 head, mated 4-day male    112 head, mated 20-day male    96 salivary gland, larvae L3 wandering    45 salivary gland, white prepupae    63 digestive system, larvae L3 wandering    195 digestive system, 1-day adult    103 digestive system, 4-day adult    231 digestive system, 20-day adult    112 fat body, larvae L3 wandering    65 fat body, white prepupae    124 fat body, pupae P8    272 carcass, larvae L3 wandering    464 carcass, 1-day adult    86 carcass, 4-day adult    193 carcass, 20-day adult    104 ovary, virgin 4-day female    845 ovary, mated 4-day female    863 testis, mated 4-day male    187 accessory gland, mated 4-day male    135 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    588 central nervous system, larvae L3    861 central nervous system, pupae P8    189 head, virgin 1-day female    87 head, virgin 4-day female    87 head, virgin 20-day female    56 head, mated 1-day female    73 head, mated 4-day female    120 head, mated 20-day female    60 head, mated 1-day male    49 head, mated 4-day male    112 head, mated 20-day male    96 salivary gland, larvae L3 wandering    45 salivary gland, white prepupae    63 digestive system, larvae L3 wandering    195 digestive system, 1-day adult    103 digestive system, 4-day adult    231 digestive system, 20-day adult    112 fat body, larvae L3 wandering    65 fat body, white prepupae    124 fat body, pupae P8    272 carcass, larvae L3 wandering    464 carcass, 1-day adult    86 carcass, 4-day adult    193 carcass, 20-day adult    104 ovary, virgin 4-day female    845 ovary, mated 4-day female    863 testis, mated 4-day male    187 accessory gland, mated 4-day male    135 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (588) central nervous system, larvae L3  (861) central nervous system, pupae P8  (189) head, virgin 1-day female  (87) head, virgin 4-day female  (87) head, virgin 20-day female  (56) head, mated 1-day female  (73) head, mated 4-day female  (120) head, mated 20-day female  (60) head, mated 1-day male  (49) head, mated 4-day male  (112) head, mated 20-day male  (96) salivary gland, larvae L3 wandering  (45) salivary gland, white prepupae  (63) digestive system, larvae L3 wandering  (195) digestive system, 1-day adult  (103) digestive system, 4-day adult  (231) digestive system, 20-day adult  (112) fat body, larvae L3 wandering  (65) fat body, white prepupae  (124) fat body, pupae P8  (272) carcass, larvae L3 wandering  (464) carcass, 1-day adult  (86) carcass, 4-day adult  (193) carcass, 20-day adult  (104) ovary, virgin 4-day female  (845) ovary, mated 4-day female  (863) testis, mated 4-day male  (187) accessory gland, mated 4-day male  (135) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (588) central nervous system, larvae L3  (861) central nervous system, pupae P8  (189) head, virgin 1-day female    87 head, virgin 4-day female    87 head, virgin 20-day female    56 head, mated 1-day female    73 head, mated 4-day female  120 head, mated 20-day female    60 head, mated 1-day male    49 head, mated 4-day male  112 head, mated 20-day male    96 salivary gland, larvae L3 wandering    45 salivary gland, white prepupae    63 digestive system, larvae L3 wandering  (195) digestive system, 1-day adult  103 digestive system, 4-day adult  (231) digestive system, 20-day adult  112 fat body, larvae L3 wandering    65 fat body, white prepupae  124 fat body, pupae P8  (272) carcass, larvae L3 wandering  (464) carcass, 1-day adult    86 carcass, 4-day adult  (193) carcass, 20-day adult  104 ovary, virgin 4-day female  (845) ovary, mated 4-day female  (863) testis, mated 4-day male  (187) accessory gland, mated 4-day male  135 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    588 central nervous system, larvae L3    861 central nervous system, pupae P8    189 head, virgin 1-day female    87 head, virgin 4-day female    87 head, virgin 20-day female    56 head, mated 1-day female    73 head, mated 4-day female    120 head, mated 20-day female    60 head, mated 1-day male    49 head, mated 4-day male    112 head, mated 20-day male    96 salivary gland, larvae L3 wandering    45 salivary gland, white prepupae    63 digestive system, larvae L3 wandering    195 digestive system, 1-day adult    103 digestive system, 4-day adult    231 digestive system, 20-day adult    112 fat body, larvae L3 wandering    65 fat body, white prepupae    124 fat body, pupae P8    272 carcass, larvae L3 wandering    464 carcass, 1-day adult    86 carcass, 4-day adult    193 carcass, 20-day adult    104 ovary, virgin 4-day female    845 ovary, mated 4-day female    863 testis, mated 4-day male    187 accessory gland, mated 4-day male    135 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the larval period, during early pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    390 embryo 02-04hr    529 embryo 04-06hr    440 embryo 06-08hr    398 embryo 08-10hr    340 embryo 10-12hr    219 embryo 12-14hr    184 embryo 14-16hr    133 embryo 16-18hr    118 embryo 18-20hr    59 embryo 20-22hr    80 embryo 22-24hr    70 larva L1    182 larva L2    260 larva L3 12hr old    167 larva L3 puffstage 1-2    140 larva L3 puffstage 3-6    168 larva L3 puffstage 7-9    221 white prepupae new    214 white prepupae 12hr    220 white prepupae 24hr    235 pupae 2d postWPP    113 pupae 3d postWPP    44 pupae 4d postWPP    56 adult male 01day    40 adult male 05day    50 adult male 30day    46 adult female 01day    246 adult female 05day    391 adult female 30day    384 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (390) embryo 02-04hr  (529) embryo 04-06hr  (440) embryo 06-08hr  (398) embryo 08-10hr  (340) embryo 10-12hr  (219) embryo 12-14hr  (184) embryo 14-16hr  (133) embryo 16-18hr  (118) embryo 18-20hr  (59) embryo 20-22hr  (80) embryo 22-24hr  (70) larva L1  (182) larva L2  (260) larva L3 12hr old  (167) larva L3 puffstage 1-2  (140) larva L3 puffstage 3-6  (168) larva L3 puffstage 7-9  (221) white prepupae new  (214) white prepupae 12hr  (220) white prepupae 24hr  (235) pupae 2d postWPP  (113) pupae 3d postWPP  (44) pupae 4d postWPP  (56) adult male 01day  (40) adult male 05day  (50) adult male 30day  (46) adult female 01day  (246) adult female 05day  (391) adult female 30day  (384) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (390) embryo 02-04hr  (529) embryo 04-06hr  (440) embryo 06-08hr  (398) embryo 08-10hr  (340) embryo 10-12hr  (219) embryo 12-14hr  (184) embryo 14-16hr  (133) embryo 16-18hr  (118) embryo 18-20hr    59 embryo 20-22hr    80 embryo 22-24hr    70 larva L1  (182) larva L2  (260) larva L3 12hr old  (167) larva L3 puffstage 1-2  (140) larva L3 puffstage 3-6  (168) larva L3 puffstage 7-9  (221) white prepupae new  (214) white prepupae 12hr  (220) white prepupae 24hr  (235) pupae 2d postWPP  (113) pupae 3d postWPP    44 pupae 4d postWPP    56 adult male 01day    40 adult male 05day    50 adult male 30day    46 adult female 01day  (246) adult female 05day  (391) adult female 30day  (384) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    390 embryo 02-04hr    529 embryo 04-06hr    440 embryo 06-08hr    398 embryo 08-10hr    340 embryo 10-12hr    219 embryo 12-14hr    184 embryo 14-16hr    133 embryo 16-18hr    118 embryo 18-20hr    59 embryo 20-22hr    80 embryo 22-24hr    70 larva L1    182 larva L2    260 larva L3 12hr old    167 larva L3 puffstage 1-2    140 larva L3 puffstage 3-6    168 larva L3 puffstage 7-9    221 white prepupae new    214 white prepupae 12hr    220 white prepupae 24hr    235 pupae 2d postWPP    113 pupae 3d postWPP    44 pupae 4d postWPP    56 adult male 01day    40 adult male 05day    50 adult male 30day    46 adult female 01day    246 adult female 05day    391 adult female 30day    384 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    390 embryo 02-04hr    529 embryo 04-06hr    440 embryo 06-08hr    398 embryo 08-10hr    340 embryo 10-12hr    219 embryo 12-14hr    184 embryo 14-16hr    133 embryo 16-18hr    118 embryo 18-20hr    59 embryo 20-22hr    80 embryo 22-24hr    70 larva L1    182 larva L2    260 larva L3 12hr old    167 larva L3 puffstage 1-2    140 larva L3 puffstage 3-6    168 larva L3 puffstage 7-9    221 white prepupae new    214 white prepupae 12hr    220 white prepupae 24hr    235 pupae 2d postWPP    113 pupae 3d postWPP    44 pupae 4d postWPP    56 adult male 01day    40 adult male 05day    50 adult male 30day    46 adult female 01day    246 adult female 05day    391 adult female 30day    384 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (390) embryo 02-04hr  (529) embryo 04-06hr  (440) embryo 06-08hr  (398) embryo 08-10hr  (340) embryo 10-12hr  (219) embryo 12-14hr  (184) embryo 14-16hr  (133) embryo 16-18hr  (118) embryo 18-20hr  (59) embryo 20-22hr  (80) embryo 22-24hr  (70) larva L1  (182) larva L2  (260) larva L3 12hr old  (167) larva L3 puffstage 1-2  (140) larva L3 puffstage 3-6  (168) larva L3 puffstage 7-9  (221) white prepupae new  (214) white prepupae 12hr  (220) white prepupae 24hr  (235) pupae 2d postWPP  (113) pupae 3d postWPP  (44) pupae 4d postWPP  (56) adult male 01day  (40) adult male 05day  (50) adult male 30day  (46) adult female 01day  (246) adult female 05day  (391) adult female 30day  (384) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (390) embryo 02-04hr  (529) embryo 04-06hr  (440) embryo 06-08hr  (398) embryo 08-10hr  (340) embryo 10-12hr  (219) embryo 12-14hr  (184) embryo 14-16hr  133 embryo 16-18hr  118 embryo 18-20hr    59 embryo 20-22hr    80 embryo 22-24hr    70 larva L1  (182) larva L2  (260) larva L3 12hr old  (167) larva L3 puffstage 1-2  140 larva L3 puffstage 3-6  (168) larva L3 puffstage 7-9  (221) white prepupae new  (214) white prepupae 12hr  (220) white prepupae 24hr  (235) pupae 2d postWPP  113 pupae 3d postWPP    44 pupae 4d postWPP    56 adult male 01day    40 adult male 05day    50 adult male 30day    46 adult female 01day  (246) adult female 05day  (391) adult female 30day  (384) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    390 embryo 02-04hr    529 embryo 04-06hr    440 embryo 06-08hr    398 embryo 08-10hr    340 embryo 10-12hr    219 embryo 12-14hr    184 embryo 14-16hr    133 embryo 16-18hr    118 embryo 18-20hr    59 embryo 20-22hr    80 embryo 22-24hr    70 larva L1    182 larva L2    260 larva L3 12hr old    167 larva L3 puffstage 1-2    140 larva L3 puffstage 3-6    168 larva L3 puffstage 7-9    221 white prepupae new    214 white prepupae 12hr    220 white prepupae 24hr    235 pupae 2d postWPP    113 pupae 3d postWPP    44 pupae 4d postWPP    56 adult male 01day    40 adult male 05day    50 adult male 30day    46 adult female 01day    246 adult female 05day    391 adult female 30day    384 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    739 Schneider line 2 Sg4    636 embryonic 1182-4H    450 embryonic GM2    280 embryonic Kc167    470 embryonic S1    446 embryonic S3    1006 leg disc CME L1    1050 wing disc CME-W2    1026 wing disc ML-DmD8    602 wing disc ML-DmD9    476 wing disc ML-DmD16-c3    805 wing disc ML-DmD21    612 wing disc ML-DmD32    581 haltere disc ML-DmD17-c3    568 eye-antennal disc ML-DmD11    458 antennal disc ML-DmD20-c5    562 mixed discs ML-DmD4-c1    669 CNS ML-DmBG1-c1    1060 CNS ML-DmBG2-c2    565 tumorous blood cells mbn2    1020 ovary fGS/OSS    408 ovary OSC    498 ovary OSS    324 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (739) Schneider line 2 Sg4  (636) embryonic 1182-4H  (450) embryonic GM2  (280) embryonic Kc167  (470) embryonic S1  (446) embryonic S3  (1006) leg disc CME L1  (1050) wing disc CME-W2  (1026) wing disc ML-DmD8  (602) wing disc ML-DmD9  (476) wing disc ML-DmD16-c3  (805) wing disc ML-DmD21  (612) wing disc ML-DmD32  (581) haltere disc ML-DmD17-c3  (568) eye-antennal disc ML-DmD11  (458) antennal disc ML-DmD20-c5  (562) mixed discs ML-DmD4-c1  (669) CNS ML-DmBG1-c1  (1060) CNS ML-DmBG2-c2  (565) tumorous blood cells mbn2  (1020) ovary fGS/OSS  (408) ovary OSC  (498) ovary OSS  (324) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (739) Schneider line 2 Sg4  (636) embryonic 1182-4H  (450) embryonic GM2  (280) embryonic Kc167  (470) embryonic S1  (446) embryonic S3  (1006) leg disc CME L1  (1050) wing disc CME-W2  (1026) wing disc ML-DmD8  (602) wing disc ML-DmD9  (476) wing disc ML-DmD16-c3  (805) wing disc ML-DmD21  (612) wing disc ML-DmD32  (581) haltere disc ML-DmD17-c3  (568) eye-antennal disc ML-DmD11  (458) antennal disc ML-DmD20-c5  (562) mixed discs ML-DmD4-c1  (669) CNS ML-DmBG1-c1  (1060) CNS ML-DmBG2-c2  (565) tumorous blood cells mbn2  (1020) ovary fGS/OSS  (408) ovary OSC  (498) ovary OSS  (324) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    739 Schneider line 2 Sg4    636 embryonic 1182-4H    450 embryonic GM2    280 embryonic Kc167    470 embryonic S1    446 embryonic S3    1006 leg disc CME L1    1050 wing disc CME-W2    1026 wing disc ML-DmD8    602 wing disc ML-DmD9    476 wing disc ML-DmD16-c3    805 wing disc ML-DmD21    612 wing disc ML-DmD32    581 haltere disc ML-DmD17-c3    568 eye-antennal disc ML-DmD11    458 antennal disc ML-DmD20-c5    562 mixed discs ML-DmD4-c1    669 CNS ML-DmBG1-c1    1060 CNS ML-DmBG2-c2    565 tumorous blood cells mbn2    1020 ovary fGS/OSS    408 ovary OSC    498 ovary OSS    324 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    739 Schneider line 2 Sg4    636 embryonic 1182-4H    450 embryonic GM2    280 embryonic Kc167    470 embryonic S1    446 embryonic S3    1006 leg disc CME L1    1050 wing disc CME-W2    1026 wing disc ML-DmD8    602 wing disc ML-DmD9    476 wing disc ML-DmD16-c3    805 wing disc ML-DmD21    612 wing disc ML-DmD32    581 haltere disc ML-DmD17-c3    568 eye-antennal disc ML-DmD11    458 antennal disc ML-DmD20-c5    562 mixed discs ML-DmD4-c1    669 CNS ML-DmBG1-c1    1060 CNS ML-DmBG2-c2    565 tumorous blood cells mbn2    1020 ovary fGS/OSS    408 ovary OSC    498 ovary OSS    324 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (739) Schneider line 2 Sg4  (636) embryonic 1182-4H  (450) embryonic GM2  (280) embryonic Kc167  (470) embryonic S1  (446) embryonic S3  (1006) leg disc CME L1  (1050) wing disc CME-W2  (1026) wing disc ML-DmD8  (602) wing disc ML-DmD9  (476) wing disc ML-DmD16-c3  (805) wing disc ML-DmD21  (612) wing disc ML-DmD32  (581) haltere disc ML-DmD17-c3  (568) eye-antennal disc ML-DmD11  (458) antennal disc ML-DmD20-c5  (562) mixed discs ML-DmD4-c1  (669) CNS ML-DmBG1-c1  (1060) CNS ML-DmBG2-c2  (565) tumorous blood cells mbn2  (1020) ovary fGS/OSS  (408) ovary OSC  (498) ovary OSS  (324) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (739) Schneider line 2 Sg4  (636) embryonic 1182-4H  (450) embryonic GM2  (280) embryonic Kc167  (470) embryonic S1  (446) embryonic S3  (1006) leg disc CME L1  (1050) wing disc CME-W2  (1026) wing disc ML-DmD8  (602) wing disc ML-DmD9  (476) wing disc ML-DmD16-c3  (805) wing disc ML-DmD21  (612) wing disc ML-DmD32  (581) haltere disc ML-DmD17-c3  (568) eye-antennal disc ML-DmD11  (458) antennal disc ML-DmD20-c5  (562) mixed discs ML-DmD4-c1  (669) CNS ML-DmBG1-c1  (1060) CNS ML-DmBG2-c2  (565) tumorous blood cells mbn2  (1020) ovary fGS/OSS  (408) ovary OSC  (498) ovary OSS  (324) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    739 Schneider line 2 Sg4    636 embryonic 1182-4H    450 embryonic GM2    280 embryonic Kc167    470 embryonic S1    446 embryonic S3    1006 leg disc CME L1    1050 wing disc CME-W2    1026 wing disc ML-DmD8    602 wing disc ML-DmD9    476 wing disc ML-DmD16-c3    805 wing disc ML-DmD21    612 wing disc ML-DmD32    581 haltere disc ML-DmD17-c3    568 eye-antennal disc ML-DmD11    458 antennal disc ML-DmD20-c5    562 mixed discs ML-DmD4-c1    669 CNS ML-DmBG1-c1    1060 CNS ML-DmBG2-c2    565 tumorous blood cells mbn2    1020 ovary fGS/OSS    408 ovary OSC    498 ovary OSS    324 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    386 cold shock, 4-day adult    281 heat shock, 4-day adult    458 Cadmium 50 mM 6 hrs, larvae L3    219 Cadmium 50 mM 12 hrs, larvae L3    312 Cadmium 50 mM 48 hrs, 4-day adult    381 Cadmium 100 mM 48 hrs, 4-day adult    589 Copper 0.5 mM 12 hrs, larvae L3    460 Copper 15 mM 48 hrs, 4-day adult    533 Zinc 5 mM 12 hrs, larvae L3    267 Zinc 4.5 mM 48 hrs, 4-day adult    332 Ethanol 2.5% 3 hrs, larvae L3    450 Ethanol 5% 3 hrs, larvae L3    207 Ethanol 10% 3 hrs, larvae L3    212 Caffeine 1.5 mg/ml 4 hrs, larvae L3    138 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    562 Caffeine 25 mg/ml 48 hrs, 4-day adult    415 Paraquat 5 mM 48 hrs, 4-day adult    451 Paraquat 10 mM 48 hrs, 4-day adult    353 Rotenone 2 μg 12 hrs, larvae L3    269 Rotenone 8 μg 12 hrs, larvae L3    266 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (386) cold shock, 4-day adult  (281) heat shock, 4-day adult  (458) Cadmium 50 mM 6 hrs, larvae L3  (219) Cadmium 50 mM 12 hrs, larvae L3  (312) Cadmium 50 mM 48 hrs, 4-day adult  (381) Cadmium 100 mM 48 hrs, 4-day adult  (589) Copper 0.5 mM 12 hrs, larvae L3  (460) Copper 15 mM 48 hrs, 4-day adult  (533) Zinc 5 mM 12 hrs, larvae L3  (267) Zinc 4.5 mM 48 hrs, 4-day adult  (332) Ethanol 2.5% 3 hrs, larvae L3  (450) Ethanol 5% 3 hrs, larvae L3  (207) Ethanol 10% 3 hrs, larvae L3  (212) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (138) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (562) Caffeine 25 mg/ml 48 hrs, 4-day adult  (415) Paraquat 5 mM 48 hrs, 4-day adult  (451) Paraquat 10 mM 48 hrs, 4-day adult  (353) Rotenone 2 μg 12 hrs, larvae L3  (269) Rotenone 8 μg 12 hrs, larvae L3  (266) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (386) cold shock, 4-day adult  (281) heat shock, 4-day adult  (458) Cadmium 50 mM 6 hrs, larvae L3  (219) Cadmium 50 mM 12 hrs, larvae L3  (312) Cadmium 50 mM 48 hrs, 4-day adult  (381) Cadmium 100 mM 48 hrs, 4-day adult  (589) Copper 0.5 mM 12 hrs, larvae L3  (460) Copper 15 mM 48 hrs, 4-day adult  (533) Zinc 5 mM 12 hrs, larvae L3  (267) Zinc 4.5 mM 48 hrs, 4-day adult  (332) Ethanol 2.5% 3 hrs, larvae L3  (450) Ethanol 5% 3 hrs, larvae L3  (207) Ethanol 10% 3 hrs, larvae L3  (212) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (138) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (562) Caffeine 25 mg/ml 48 hrs, 4-day adult  (415) Paraquat 5 mM 48 hrs, 4-day adult  (451) Paraquat 10 mM 48 hrs, 4-day adult  (353) Rotenone 2 μg 12 hrs, larvae L3  (269) Rotenone 8 μg 12 hrs, larvae L3  (266) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    386 cold shock, 4-day adult    281 heat shock, 4-day adult    458 Cadmium 50 mM 6 hrs, larvae L3    219 Cadmium 50 mM 12 hrs, larvae L3    312 Cadmium 50 mM 48 hrs, 4-day adult    381 Cadmium 100 mM 48 hrs, 4-day adult    589 Copper 0.5 mM 12 hrs, larvae L3    460 Copper 15 mM 48 hrs, 4-day adult    533 Zinc 5 mM 12 hrs, larvae L3    267 Zinc 4.5 mM 48 hrs, 4-day adult    332 Ethanol 2.5% 3 hrs, larvae L3    450 Ethanol 5% 3 hrs, larvae L3    207 Ethanol 10% 3 hrs, larvae L3    212 Caffeine 1.5 mg/ml 4 hrs, larvae L3    138 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    562 Caffeine 25 mg/ml 48 hrs, 4-day adult    415 Paraquat 5 mM 48 hrs, 4-day adult    451 Paraquat 10 mM 48 hrs, 4-day adult    353 Rotenone 2 μg 12 hrs, larvae L3    269 Rotenone 8 μg 12 hrs, larvae L3    266 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    386 cold shock, 4-day adult    281 heat shock, 4-day adult    458 Cadmium 50 mM 6 hrs, larvae L3    219 Cadmium 50 mM 12 hrs, larvae L3    312 Cadmium 50 mM 48 hrs, 4-day adult    381 Cadmium 100 mM 48 hrs, 4-day adult    589 Copper 0.5 mM 12 hrs, larvae L3    460 Copper 15 mM 48 hrs, 4-day adult    533 Zinc 5 mM 12 hrs, larvae L3    267 Zinc 4.5 mM 48 hrs, 4-day adult    332 Ethanol 2.5% 3 hrs, larvae L3    450 Ethanol 5% 3 hrs, larvae L3    207 Ethanol 10% 3 hrs, larvae L3    212 Caffeine 1.5 mg/ml 4 hrs, larvae L3    138 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    562 Caffeine 25 mg/ml 48 hrs, 4-day adult    415 Paraquat 5 mM 48 hrs, 4-day adult    451 Paraquat 10 mM 48 hrs, 4-day adult    353 Rotenone 2 μg 12 hrs, larvae L3    269 Rotenone 8 μg 12 hrs, larvae L3    266 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (386) cold shock, 4-day adult  (281) heat shock, 4-day adult  (458) Cadmium 50 mM 6 hrs, larvae L3  (219) Cadmium 50 mM 12 hrs, larvae L3  (312) Cadmium 50 mM 48 hrs, 4-day adult  (381) Cadmium 100 mM 48 hrs, 4-day adult  (589) Copper 0.5 mM 12 hrs, larvae L3  (460) Copper 15 mM 48 hrs, 4-day adult  (533) Zinc 5 mM 12 hrs, larvae L3  (267) Zinc 4.5 mM 48 hrs, 4-day adult  (332) Ethanol 2.5% 3 hrs, larvae L3  (450) Ethanol 5% 3 hrs, larvae L3  (207) Ethanol 10% 3 hrs, larvae L3  (212) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (138) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (562) Caffeine 25 mg/ml 48 hrs, 4-day adult  (415) Paraquat 5 mM 48 hrs, 4-day adult  (451) Paraquat 10 mM 48 hrs, 4-day adult  (353) Rotenone 2 μg 12 hrs, larvae L3  (269) Rotenone 8 μg 12 hrs, larvae L3  (266) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (386) cold shock, 4-day adult  (281) heat shock, 4-day adult  (458) Cadmium 50 mM 6 hrs, larvae L3  (219) Cadmium 50 mM 12 hrs, larvae L3  (312) Cadmium 50 mM 48 hrs, 4-day adult  (381) Cadmium 100 mM 48 hrs, 4-day adult  (589) Copper 0.5 mM 12 hrs, larvae L3  (460) Copper 15 mM 48 hrs, 4-day adult  (533) Zinc 5 mM 12 hrs, larvae L3  (267) Zinc 4.5 mM 48 hrs, 4-day adult  (332) Ethanol 2.5% 3 hrs, larvae L3  (450) Ethanol 5% 3 hrs, larvae L3  (207) Ethanol 10% 3 hrs, larvae L3  (212) Caffeine 1.5 mg/ml 4 hrs, larvae L3  138 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (562) Caffeine 25 mg/ml 48 hrs, 4-day adult  (415) Paraquat 5 mM 48 hrs, 4-day adult  (451) Paraquat 10 mM 48 hrs, 4-day adult  (353) Rotenone 2 μg 12 hrs, larvae L3  (269) Rotenone 8 μg 12 hrs, larvae L3  (266) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    386 cold shock, 4-day adult    281 heat shock, 4-day adult    458 Cadmium 50 mM 6 hrs, larvae L3    219 Cadmium 50 mM 12 hrs, larvae L3    312 Cadmium 50 mM 48 hrs, 4-day adult    381 Cadmium 100 mM 48 hrs, 4-day adult    589 Copper 0.5 mM 12 hrs, larvae L3    460 Copper 15 mM 48 hrs, 4-day adult    533 Zinc 5 mM 12 hrs, larvae L3    267 Zinc 4.5 mM 48 hrs, 4-day adult    332 Ethanol 2.5% 3 hrs, larvae L3    450 Ethanol 5% 3 hrs, larvae L3    207 Ethanol 10% 3 hrs, larvae L3    212 Caffeine 1.5 mg/ml 4 hrs, larvae L3    138 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    562 Caffeine 25 mg/ml 48 hrs, 4-day adult    415 Paraquat 5 mM 48 hrs, 4-day adult    451 Paraquat 10 mM 48 hrs, 4-day adult    353 Rotenone 2 μg 12 hrs, larvae L3    269 Rotenone 8 μg 12 hrs, larvae L3    266 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_03 mE1_20_mRNA_expression_cluster_10
External Data & Images
Linkouts	BDGP expression data • LD16456 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0016685 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7917-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable NlpCC01224 viable, with Scer\GAL4pnr-MD237 NlpGD12319 Phenotype manifest in Allele
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of Nlp Class Mutagen Stocks Known lesion NlpEP3555 P-element activity 1 -- NlpEY03900 P-element activity 1 -- NlpCC01224 P-element activity 0 Yes NlpCPTI003532 piggyBac transposase 0 Yes
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Nlp Class Mutagen Stocks Known lesion NlpGD12319 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes NlpHMS00556 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes NlpNIG.7917R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6213 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12319} NA P{NIG.7917R} NA P{TRiP.HMS00556} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}NlpEP3555 NA P{EPgy2}NlpEY03900 NA miscellaneous insertions P{PTT-GC}NlpCC01224 NA PBac{768.FSVS-0}NlpCPTI003532 NA
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
nucleolus inferred from direct assay (Colflesh et al., 1999) nucleus inferred from direct assay (Colflesh et al., 1999, Ito et al., 1996)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
ATPase activity, coupled non-traceable author statement (Swiss-Prot Project Members, 1999.12.15) histone binding non-traceable author statement (Swiss-Prot Project Members, 1999.12.15) traceable author statement (Ito et al., 1997) nucleic acid binding inferred from electronic annotation with InterPro:IPR004301 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
nucleosome positioning non-traceable author statement (Swiss-Prot Project Members, 1999.12.15)
Cellular Component
CV term Evidence References
nucleus non-traceable author statement (Swiss-Prot Project Members, 1999.12.15)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Nlp - 14-3-3ε experimental knowledge based (Guruharsha et al., 2011) Nlp - ATPsyn-β experimental knowledge based (Guruharsha et al., 2011) Nlp - Aats-asn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - Akap200 experimental knowledge based (Guruharsha et al., 2011) Nlp - Ald experimental knowledge based (Guruharsha et al., 2011) Nlp - Aldh-III anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - AnxB10 experimental knowledge based (Guruharsha et al., 2011) Nlp - Arpc2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - Bacc experimental knowledge based (Guruharsha et al., 2011) Nlp - CG10265 experimental knowledge based (Guruharsha et al., 2011) Nlp - CG10495 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG10638 experimental knowledge based (Guruharsha et al., 2011) Nlp - CG10673 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG11236 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG11267 experimental knowledge based (Guruharsha et al., 2011) Nlp - CG11279 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG11459 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG11652 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG11796 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG11876 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG12200 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG12207 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG13126 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG13295 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG13539 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG13983 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Nlp - CG14020 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG14024 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG14141 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG14715 experimental knowledge based (Guruharsha et al., 2011) Nlp - CG14762 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG14968 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG14969 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG15209 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG15643 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG16817 experimental knowledge based (Guruharsha et al., 2011) Nlp - CG17162 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG17568 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG18004 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG18335 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG18347 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG1910 experimental knowledge based (Guruharsha et al., 2011) Nlp - CG1941 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG2004 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG2656 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG2852 experimental knowledge based (Guruharsha et al., 2011) Nlp - CG2862 experimental knowledge based (Guruharsha et al., 2011) Nlp - CG2931 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG2982 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG30010 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG30339 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG3036 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG3038 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG31265 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG31810 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG31917 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG31961 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG33156 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG33213 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG33278 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG34133 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG3819 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG40160 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG4278 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG4598 experimental knowledge based (Guruharsha et al., 2011) Nlp - CG4866 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG4936 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG5080 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG5174 experimental knowledge based (Guruharsha et al., 2011) Nlp - CG5380 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG5382 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG5445 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG5538 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG5577 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG5646 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG5986 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG6073 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG6084 experimental knowledge based (Guruharsha et al., 2011) Nlp - CG6178 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG6321 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG6712 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG7091 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG7197 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG7272 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG7288 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG7655 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG7669 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG7911 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Nlp - CG8036 experimental knowledge based (Guruharsha et al., 2011) Nlp - CG8117 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG8239 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG8368 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG8568 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG8654 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG8891 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG8952 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CG8993 experimental knowledge based (Guruharsha et al., 2011) Nlp - CSN4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - Chd64 experimental knowledge based (Guruharsha et al., 2011) Nlp - CkIIβ2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - Cpr100A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - Cpr11A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - Crc experimental knowledge based (Guruharsha et al., 2011) Nlp - Ctr1B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - CycK anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - Cyp1 experimental knowledge based (Guruharsha et al., 2011) Nlp - Cyp28a5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - Cyp6a13 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - Cyp9b2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - Cyt-b5-r anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - D1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - Der-2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - Df31 experimental knowledge based (Guruharsha et al., 2011) Nlp - Dim1 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Nlp - E(var)3-9 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - ERp60 experimental knowledge based (Guruharsha et al., 2011) Nlp - Eb1 experimental knowledge based (Guruharsha et al., 2011) Nlp - Ef2b experimental knowledge based (Guruharsha et al., 2011) Nlp - EndoGI experimental knowledge based (Guruharsha et al., 2011) Nlp - Eno experimental knowledge based (Guruharsha et al., 2011) Nlp - FK506-bp2 experimental knowledge based (Guruharsha et al., 2011) Nlp - Fdh anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - Fie anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Nlp - Fim experimental knowledge based (Guruharsha et al., 2011) Nlp - Fkbp13 experimental knowledge based (Guruharsha et al., 2011) Nlp - GM130 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - GstE6 experimental knowledge based (Guruharsha et al., 2011) Nlp - GstO3 experimental knowledge based (Guruharsha et al., 2011) Nlp - Gαi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - His2Av anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - HmgD experimental knowledge based (Guruharsha et al., 2011) Nlp - Hop experimental knowledge based (Guruharsha et al., 2011) Nlp - Hsl anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - Hsp83 experimental knowledge based (Guruharsha et al., 2011) Nlp - Inos experimental knowledge based (Guruharsha et al., 2011) Nlp - Kdm4A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - Lac anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - Lip4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - MESK2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - MFS3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - Mdh2 experimental knowledge based (Guruharsha et al., 2011) Nlp - Mip anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - Mkk4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - Moe experimental knowledge based (Guruharsha et al., 2011) Nlp - Nacα experimental knowledge based (Guruharsha et al., 2011) Nlp - Ndfip anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - Npc2g anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - Ntf-2 experimental knowledge based (Guruharsha et al., 2011) Nlp - ORMDL anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - Oat anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - Odc1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - PHGPx experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Nlp - PI31 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - Pdi experimental knowledge based (Guruharsha et al., 2011) Nlp - Peb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - Pex16 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - Pgd experimental knowledge based (Guruharsha et al., 2011) Nlp - Pglym78 experimental knowledge based (Guruharsha et al., 2011) Nlp - Pp4-19C anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - Proct anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - Prx2540-2 experimental knowledge based (Guruharsha et al., 2011) Nlp - Ran anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - Rbp1-like anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - RhoGDI experimental knowledge based (Guruharsha et al., 2011) Nlp - RnrL anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - SP2637 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - SelD anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - Sh3β experimental knowledge based (Guruharsha et al., 2011) Nlp - Sod experimental knowledge based (Guruharsha et al., 2011) Nlp - Ssl anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - Su(var)205 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - TER94 experimental knowledge based (Guruharsha et al., 2011) Nlp - Tango2 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Nlp - Tctp experimental knowledge based (Guruharsha et al., 2011) Nlp - TotX anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - TpnC25D anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Nlp - Tre1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - Trx-2 experimental knowledge based (Guruharsha et al., 2011) Nlp - Trxr-1 experimental knowledge based (Guruharsha et al., 2011) Nlp - Uch experimental knowledge based (Guruharsha et al., 2011) Nlp - ZnT63C anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - aralar1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - aur anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - ave anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - awd experimental knowledge based (Guruharsha et al., 2011) Nlp - bai anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - capt experimental knowledge based (Guruharsha et al., 2011) Nlp - cdc2c anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - chic experimental knowledge based (Guruharsha et al., 2011) Nlp - cib experimental knowledge based (Guruharsha et al., 2011) Nlp - dUTPase experimental knowledge based (Guruharsha et al., 2011) Nlp - dlg1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - dod experimental knowledge based (Guruharsha et al., 2011) Nlp - eEF1δ experimental knowledge based (Guruharsha et al., 2011) Nlp - eIF-5A experimental knowledge based (Guruharsha et al., 2011) Nlp - exu anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - fabp experimental knowledge based (Guruharsha et al., 2011) Nlp - fax experimental knowledge based (Guruharsha et al., 2011) Nlp - fbp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - fd59A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - l(2)35Be anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - ldbr anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - loqs anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - mRpL19 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - mus209 experimental knowledge based (Guruharsha et al., 2011) Nlp - nes anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - p47 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - regucalcin experimental knowledge based (Guruharsha et al., 2011) Nlp - scf experimental knowledge based (Guruharsha et al., 2011) Nlp - scu experimental knowledge based (Guruharsha et al., 2011) Nlp - smt3 experimental knowledge based (Guruharsha et al., 2011) Nlp - tub anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - twr anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nlp - yip2 experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Nlp allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68416 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0016685 DroID - A comprehensive database of gene and protein interactions. • FBgn0016685 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43560
Orthologs
OrthoDB Orthologs (30) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6640ZP Dipteran inclusive ortholog search EOG60GD1B Insect inclusive ortholog search EOG65MM3B Arthropod inclusive ortholog search EOG6FFBJS Metazoa inclusive ortholog search EOG61P6FV
Orthologs in Drosophila Species (EOG6640ZP)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Nlp     Drosophila simulans   Dsim\GD21493 Y   Drosophila sechellia   Dsec\GM12851 Y   Drosophila erecta   Dere\GG11720 Y   Drosophila yakuba   Dyak\GE10848 Y   Drosophila ananassae   Dana\GF18816 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA20685 Y   Drosophila persimilis   Dper\GL14018 Y   Drosophila willistoni   Dwil\GK13921 Y   Drosophila virilis   Dvir\GJ14400 Y   Drosophila mojavensis   Dmoj\GI10803 Y   Drosophila grimshawi   Dgri\GH18574 Y
Orthologs in non-Drosophila Dipterans (EOG60GD1B)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL003750   Anopheles gambiae Malaria mosquito  Agam\AGAP004395   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ003887
Orthologs in non-Dipteran Insects (EOG65MM3B)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB47396 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG023772 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH24605 Y Atta cephalotes Leafcutter ant  Acep\ACEP27638 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO16092 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL13372 Y Linepithema humile Argentine ant  Lhum\LH11268 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB15264 Y Solenopsis invicta Red fire ant  Sinv\SINV20593 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI001342 Y Bombyx mori Silkmoth  Bmor\BGIBMGA002309 Y Pediculus humanus Human body louse  Phum\PHUM018370 Y Tribolium castaneum Red flour beetle  Tcas\TC012176 Y
Orthologs in non-Insect Arthropods (EOG6FFBJS)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\cytb Y
Orthologs in non-Arthropod Metazoa (EOG61P6FV)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000016499 Y
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD21493 Drosophila sechellia Dsec\GM12851 Drosophila erecta Dere\GG11720 Drosophila yakuba Dyak\GE10848 Drosophila ananassae Dana\GF18816 Drosophila pseudoobscura pseudoobscura Dpse\GA20685 Drosophila persimilis Dper\GL14018 Drosophila willistoni Dwil\GK13921 Drosophila virilis Dvir\GJ14400 Drosophila mojavensis Dmoj\GI10803 Drosophila grimshawi Dgri\GH18574
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	6976 w1118; P{EP}NlpEP3555 15919 y1 w67c23; P{EPgy2}NlpEY03900 33688 y1 sc* v1; P{TRiP.HMS00556}attP2
VDRC	v22623 w1118; P{GD12319}v22623 v22625 w1118; P{GD12319}v22625
Genomic Clones ( 1 )
	BACR07A18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 115 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD16456
Other clones	DPiM_LD16456
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT29828 AT31811 GH12485 GH16354 GM02816 GM08174 GM10575 GM14980 GM15674 GM20586 GM21085 LD04429 LD06511 LD07039 LD07356 LD11328 LD14724 LD26141 LD31365 LD32530 LD38064 LD42666 LD45604 LD48023 LP03369 RE07992 RE22451 RE23386 RE30941 RE32527 RE40423 RE72991 RH01820 RH02636 RH14091 RH51316 RH51943 SD04367 SD05749 SD12516 SD16475 SD27975
Other clones	19508 53328 56992 77947 78269 78772 121233 157943 214249.61 bs41h12 bs75c01 CK01.18D.E1 CK01.53A.G2 CK01.64B.F4 CK01.75A.F5 CK01.91A.H4 CK01.93C.D6 Dmel_dig_005038_0620_2155 Dmel_dig_005659_0723_0495 Dmel_dig_008279_0630_0511 Dmel_dig_011446_0634_2290 Dmel_dig_012537_0640_1523 Dmel_dig_013767_0624_2518 Dmel_dig_014390_0714_2142 Dmel_dig_015367_0713_2646 Dmel_dig_017218_0678_3002 Dmel_dig_017849_0705_3335 Dmel_dig_020265_0622_2456 Dmel_dig_020634_0665_3396 Dmel_dig_020730_0716_1944 Dmel_dig_021245_0713_1537 Dmel_neb_005491_0691_1505 Dmel_neb_009589_0845_1062 Dmel_neb_010034_0691_1490 Dmel_neb_010906_0357_0307 Dmel_neb_011204_0201_0665 Dmel_neb_011254_0326_1884 Dmel_neb_011605_0887_3284 Dmel_neb_013382_0125_1482 Dmel_neb_014388_0837_0606 EC31426 EC34310 EK039228 EK042857 EK049452 EK052241 EK058823 EK065054 EK071362 EK072947 EK132460 EK170557 EK179704 EK211640 EK211917 EK241233 EK260654 EP12236 EP12406 FGM104G06 FGM212B04 FGM232H02 IP17419 IP18342 RP003009398 RP003015233 RP003167065 RP003359664 RP003524134 RP003573301 UUGC0569
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0016685 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43560
Antibody Information
	polyclonal (Ito et al., 1996, Ito et al., 1996)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	Nlp protein can substitute for Xenopus nucleoplasmin in catalysing the in vitro decondensation of demembranated Xenopus sperm, this is accompanied by binding of Nlp to sperm chromatin. (Crevel et al., 1997) Nlp is a nuclear protein present throughout development. Purified and recombinant proteins bind to core histones and can function in the assembly of approximately regularly spaced nucleosomal arrays. (Ito et al., 1996)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079833 NM_001276165 RefSeq (Proteins) • NP_524557 NP_001263094 DDBJ / EMBL / GenBank • AA441499 AAC47294 AAC47295 AAF56988 AAM50246 AGB96473 AQ073010 AW942420 AY119592 CAA67679 U59497 U59498 X99293 Entrez Gene - A searchable database of RefSeq genes. • 43560 UniProtKB/Swiss-Prot • Q27415
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Nucleoplasmin (IPR004301) Nucleoplasmin core domain (IPR024057) PDB - Protein Data Bank. An information portal to biological macromolecular structures • 1NLQ BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD16456
Linkouts
	BioGRID - A database of protein and genetic interactions • 68416 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0016685 DroID - A comprehensive database of gene and protein interactions. • FBgn0016685 DRSC - Results from RNAi screens. • FBgn0016685 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0016685 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7917-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0016685 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43560 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43560 modMine - Data generated by the modENCODE project. • FBgn0016685
Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym	CG7917 (Ni et al., 2010.12.1, Cammarato et al., 2011) CRP1 (Crevel, 1996.7.11, Colflesh et al., 1999, Ito et al., 1997, Crevel et al., 1997) Crp1   dNLP (Namboodiri et al., 2003, Ridgway and Almouzni, 2001, Tyler et al., 1999, Ito, 1996.5.30, Ito et al., 1997, Ito et al., 1997, Crevel et al., 1997, Ito et al., 1996, Ellis, 2006) dNLP-S (Ito, 1996.5.30) Nlp (Buszczak et al., 2007, Singer and Gall, 2011, McElroy et al., 2008, Rogers et al., 2009, Nie et al., 2009, Japanese National Institute of Genetics, 2012.5.21) p22 (Ito et al., 1997)
Name Synonym	Chromatin decondensation protein 1   nucleophosmin (Rogers et al., 2009) Nucleoplasmin (Singer and Gall, 2011, Cammarato et al., 2011) nucleoplasmin-1 (Mello and Almouzni, 2001) Nucleoplasmin-like (Ito et al., 1996)
Secondary FlyBase IDs
	FBgn0016133
References ( 42 )
Generate a list of	All references relating to this gene ( 42 )
List References by type	Research paper  ( 14 ) Supplementary material  ( 6 ) Review  ( 4 ) Personal communication to FlyBase  ( 9 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 3 ) Stock list  ( 1 ) Protein sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 2 )
	Crawford et al., 2012, Cell Death Differ. 19(12): 2040--2048 Conservation of caspase substrates across metazoans suggests hierarchical importance of signaling pathways over specific targets and cleavage site motifs in apoptosis. [FBrf0220233] Singer and Gall, 2011, Nucleus 2(5): 403--409 An inducible nuclear body in the Drosophila germinal vesicle. [FBrf0216533] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...