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Gene Dmel\Nurf-38

General Information
Symbol	Dmel\Nurf-38	Species	D. melanogaster
Name	Nucleosome remodeling factor - 38kD	Annotation symbol	CG4634
Feature type	protein_coding_gene	FlyBase ID	FBgn0016687
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	NURF, Nurf38, dNURF, p38, l(2)k16102
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	60D5-60D5	Sequence location	2R:20,446,490..20,448,610 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Nucleosome remodeling factor - 38kD is referred to in FlyBase by the symbol Dmel\Nurf-38 (CG4634, FBgn0016687). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: inorganic diphosphatase activity. There is experimental evidence that it is involved in the biological process: ecdysone receptor-mediated signaling pathway; transcription, DNA-dependent; nucleosome mobilization; positive regulation of Notch signaling pathway; chromatin remodeling. 6 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Inorganic pyrophosphatase. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed within 00-12 and 18-24 hour embryonic stages, during early larval stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval Malpighian tubules, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1637982_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Nurf-38. Gene sequence location is 2R:20446490..20448610.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features BKN22703 HFA04629
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 60D5-60D5   Limits computationally determined from genome sequence between P{PZ}bs03267&P{lacW}l(2)k10502k10502 and P{lacW}Nurf-38k16102
Experimentally Determined Cytological Location
Cytogenetic map Notes References 60C-60C     (Gdula, 1998.8.20) 60C-60C     (Gdula, 1998.8.20) 60D5-60D6   (determined by in situ hybridisation)   (Spradling et al., 1999) 60C-60C     (Gdula et al., 1998) 60D5-60D6     (Beaton, 1997.12.27) 60D5-60D6     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Nurf-38 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Nurf-38-RA FBtr0072343  NM_079125   1178   338 Nurf-38-RB FBtr0273253  NM_001144286   1143   290 Nurf-38-RC FBtr0305985     1273   290
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Nurf-38-PA   FBpp0072250   37.9   338   7.01     NP_523849   AAF47227 Nurf-38-PB   FBpp0271761   32.6   290   5.41     NP_001137758   ACL83211 Nurf-38-PC   FBpp0297127   32.5   290   5.66
Additional Polypeptide Data & Comments
Reported size (kDa)	290 (aa); 40 (kD observed); 33 (kD predicted) (Gdula et al., 1998)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Inorganic pyrophosphatase (IPR008162)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA540544   AA540556   AA540895   AA802584   AA821023   AE013599 AAF47227   AE013599 ACL83211   AF085600 AAC97111   AF085601 AAC97112   AI062013   AI063559   AI106806   AI108252   AI135300   AI135656   AI237966   AI260097   AI260449   AI388850   AI402036   AI403266   AI405738   AI514001   AQ026097   AX094078   AY075479 AAL68291   BF503752   BG636657   BI165383   BI230742   BI231538   BI235232   BI240157   BI242153   BI354532   BI354554   BI355998   BI374156   BI566130   BI566421   BI567144   BI567273   BI574126   BI578135   BI579213   BI584813   BI612132   BI617368   BI621223   BI623601   BI630095   BP557152   BQ103007   BT058058   BX026881   BX041029   BX045947   BX067354   CK131981   CK660654   CK661711   CK661951   CO279022   CO319520   CO321152   CO330887   CO337094   DQ440278   EC052211   EC052673   EC053167   EC053715   EC054649   EC055604   EC056562   EC084197   EC090351   EC248648   EC250250   EC266071   EL873470   EL882405   EL882521   EL886252   EV574887   EV578692   EV578826   EV584460   EV584762   EV584943   EV585436   EV591294   EV591690   GH747935   GH748095   GH749646   GH750765   GH751584   GH751871   GH751918   GH752588   GH752876   GH753278   GH754176   GH755301   GH755851   GH756681   GH756962   GH757249   GH758122   GH758663   GH759234   GH759663   GH770117   GH770240   GH770662   GH770735   GH771154   GH772480   GH772643   GH773238   GH774377   GH775907   GH776089   GH783057   GH783504   GH783632   GH783863   GH785289   GH785942   GH786961   GH787212   GH788399   GH789459   GH790709   GH790952   GH792082   GH792541   GH794561   GH797298   GH797965   GH800165   GH800680   GH801723   GH801778   GH802414   GH803146   GH803717   GH804707   GH805489   GH805760   GH805797   GH806823   GH807377   GH808185   GH808798   GH809370   GH810527   GH811964   GH813187   GH813577   GH813798   GH814257   GH815162   GH816618   GH816940   GH818732   GH820271   GH820702   GH820805   GH821579   GH822602   GH826142   GH826852   GH827797   GH827919   GH828310   GH829098   GH830010   GH830230   GH831033   GH831795   GH832545   GH833387   GH834293   GH834622   GH836270   GH837607   GH837919   GH839316   GH839385   GH839562   GH839612   GH841306   GH841365   GH842088   GH843121   GH843281   GH843582   GH844907   GH847187   GH848120   GH849574   GH850315   GH851376   GH851718   GH853136   GH853734   GH853759   GH854882   GH856272   GH856889   GH857382   GH857857   GH859854   GH860109   GH860701   GH861181   GH861920   GH862662   GH862773   GH863414   GH865263   GH865888   GH866008   GH866564   GH866895   GH867950   GH869680   GH869682   GH875154   GH875753   GH876324   GH877149   GH878330   GH878840   GH879242   GH880203   GH881107   GH881706   GH881711   GH881981   GH882091   GH882421   GH882579   GH884043   GH885145   GH886241   GH889032   GH889272   GH889297   GH890216   GH890864   GH891125   GH892400   GH893344   GH893946   GH895202   GH895834   GH895938   GH896550   GH897586   GH900380   GH900424   GH900852   GH900953   GH901985   GH901991   GH902436   GH903213   GH903789   GH903815   GH904359   GH904500   GH904678   GH905579   GH906733   GH906934   GH908152   GH908575   GH908631   GH909791   GH909929   GH910434   GH911787   GH912346   GH912966   GH913240   GH913366   GH913514   GH913976   GH914226   GH914459   GH914508   GH915076   GH915257   GH919923   GH921345   GH922095   GH925068   GH926679   GH927291   GH927547   GH928698   GH929201   GH930128   GH930423   GH931940   GH935005   GH935198   GH935533   GH935566   GH936524   GH937237   GH937295   GH937545   GH938079   GH938081   GH942322
UniProtKB/Swiss-Prot	O77460
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010) day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
	Nurf-38 protein is observed in both the cytoplasm and the nucleus. (Gdula et al., 1998)
Marker for
Subcellular Localization
CV Term	nucleus cytoplasm (Gdula et al., 1998)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0016687    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0016687 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed within 00-12 and 18-24 hour embryonic stages, during early larval stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0016687 expression level Developmental Stage   Expression Level embryo 00-02hr    16820 embryo 02-04hr    5620 embryo 04-06hr    8285 embryo 06-08hr    8583 embryo 08-10hr    8674 embryo 10-12hr    11760 embryo 12-14hr    6867 embryo 14-16hr    7453 embryo 16-18hr    8026 embryo 18-20hr    8802 embryo 20-22hr    12237 embryo 22-24hr    11979 larva L1    21580 larva L2    24624 larva L3 12hr old    22602 larva L3 puffstage 1-2    9513 larva L3 puffstage 3-6    7620 larva L3 puffstage 7-9    8063 white prepupae new    7876 white prepupae 12hr    6687 white prepupae 24hr    7663 pupae 2d postWPP    7102 pupae 3d postWPP    6792 pupae 4d postWPP    7488 adult male 01day    12513 adult male 05day    12546 adult male 30day    11497 adult female 01day    18049 adult female 05day    19635 adult female 30day    19091 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (16820) embryo 02-04hr  (5620) embryo 04-06hr  (8285) embryo 06-08hr  (8583) embryo 08-10hr  (8674) embryo 10-12hr  (11760) embryo 12-14hr  (6867) embryo 14-16hr  (7453) embryo 16-18hr  (8026) embryo 18-20hr  (8802) embryo 20-22hr  (12237) embryo 22-24hr  (11979) larva L1  (21580) larva L2  (24624) larva L3 12hr old  (22602) larva L3 puffstage 1-2  (9513) larva L3 puffstage 3-6  (7620) larva L3 puffstage 7-9  (8063) white prepupae new  (7876) white prepupae 12hr  (6687) white prepupae 24hr  (7663) pupae 2d postWPP  (7102) pupae 3d postWPP  (6792) pupae 4d postWPP  (7488) adult male 01day  (12513) adult male 05day  (12546) adult male 30day  (11497) adult female 01day  (18049) adult female 05day  (19635) adult female 30day  (19091) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (16820) embryo 02-04hr  (5620) embryo 04-06hr  (8285) embryo 06-08hr  (8583) embryo 08-10hr  (8674) embryo 10-12hr  (11760) embryo 12-14hr  (6867) embryo 14-16hr  (7453) embryo 16-18hr  (8026) embryo 18-20hr  (8802) embryo 20-22hr  (12237) embryo 22-24hr  (11979) larva L1  (21580) larva L2  (24624) larva L3 12hr old  (22602) larva L3 puffstage 1-2  (9513) larva L3 puffstage 3-6  (7620) larva L3 puffstage 7-9  (8063) white prepupae new  (7876) white prepupae 12hr  (6687) white prepupae 24hr  (7663) pupae 2d postWPP  (7102) pupae 3d postWPP  (6792) pupae 4d postWPP  (7488) adult male 01day  (12513) adult male 05day  (12546) adult male 30day  (11497) adult female 01day  (18049) adult female 05day  (19635) adult female 30day  (19091) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (16820) embryo 02-04hr    5620 embryo 04-06hr    8285 embryo 06-08hr    8583 embryo 08-10hr    8674 embryo 10-12hr  (11760) embryo 12-14hr    6867 embryo 14-16hr    7453 embryo 16-18hr    8026 embryo 18-20hr    8802 embryo 20-22hr  (12237) embryo 22-24hr  (11979) larva L1  (21580) larva L2  (24624) larva L3 12hr old  (22602) larva L3 puffstage 1-2    9513 larva L3 puffstage 3-6    7620 larva L3 puffstage 7-9    8063 white prepupae new    7876 white prepupae 12hr    6687 white prepupae 24hr    7663 pupae 2d postWPP    7102 pupae 3d postWPP    6792 pupae 4d postWPP    7488 adult male 01day  (12513) adult male 05day  (12546) adult male 30day  (11497) adult female 01day  (18049) adult female 05day  (19635) adult female 30day  (19091) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    16820 embryo 02-04hr    5620 embryo 04-06hr    8285 embryo 06-08hr    8583 embryo 08-10hr    8674 embryo 10-12hr    11760 embryo 12-14hr    6867 embryo 14-16hr    7453 embryo 16-18hr    8026 embryo 18-20hr    8802 embryo 20-22hr    12237 embryo 22-24hr    11979 larva L1    21580 larva L2    24624 larva L3 12hr old    22602 larva L3 puffstage 1-2    9513 larva L3 puffstage 3-6    7620 larva L3 puffstage 7-9    8063 white prepupae new    7876 white prepupae 12hr    6687 white prepupae 24hr    7663 pupae 2d postWPP    7102 pupae 3d postWPP    6792 pupae 4d postWPP    7488 adult male 01day    12513 adult male 05day    12546 adult male 30day    11497 adult female 01day    18049 adult female 05day    19635 adult female 30day    19091 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0016687 expression level Developmental Stage   Expression Level embryo 00-02hr    16820 embryo 02-04hr    5620 embryo 04-06hr    8285 embryo 06-08hr    8583 embryo 08-10hr    8674 embryo 10-12hr    11760 embryo 12-14hr    6867 embryo 14-16hr    7453 embryo 16-18hr    8026 embryo 18-20hr    8802 embryo 20-22hr    12237 embryo 22-24hr    11979 larva L1    21580 larva L2    24624 larva L3 12hr old    22602 larva L3 puffstage 1-2    9513 larva L3 puffstage 3-6    7620 larva L3 puffstage 7-9    8063 white prepupae new    7876 white prepupae 12hr    6687 white prepupae 24hr    7663 pupae 2d postWPP    7102 pupae 3d postWPP    6792 pupae 4d postWPP    7488 adult male 01day    12513 adult male 05day    12546 adult male 30day    11497 adult female 01day    18049 adult female 05day    19635 adult female 30day    19091 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (16820) embryo 02-04hr  (5620) embryo 04-06hr  (8285) embryo 06-08hr  (8583) embryo 08-10hr  (8674) embryo 10-12hr  (11760) embryo 12-14hr  (6867) embryo 14-16hr  (7453) embryo 16-18hr  (8026) embryo 18-20hr  (8802) embryo 20-22hr  (12237) embryo 22-24hr  (11979) larva L1  (21580) larva L2  (24624) larva L3 12hr old  (22602) larva L3 puffstage 1-2  (9513) larva L3 puffstage 3-6  (7620) larva L3 puffstage 7-9  (8063) white prepupae new  (7876) white prepupae 12hr  (6687) white prepupae 24hr  (7663) pupae 2d postWPP  (7102) pupae 3d postWPP  (6792) pupae 4d postWPP  (7488) adult male 01day  (12513) adult male 05day  (12546) adult male 30day  (11497) adult female 01day  (18049) adult female 05day  (19635) adult female 30day  (19091) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (16820) embryo 02-04hr  (5620) embryo 04-06hr  (8285) embryo 06-08hr  (8583) embryo 08-10hr  (8674) embryo 10-12hr  (11760) embryo 12-14hr  (6867) embryo 14-16hr  (7453) embryo 16-18hr  (8026) embryo 18-20hr  (8802) embryo 20-22hr  (12237) embryo 22-24hr  (11979) larva L1  (21580) larva L2  (24624) larva L3 12hr old  (22602) larva L3 puffstage 1-2  (9513) larva L3 puffstage 3-6  (7620) larva L3 puffstage 7-9  (8063) white prepupae new  (7876) white prepupae 12hr  (6687) white prepupae 24hr  (7663) pupae 2d postWPP  (7102) pupae 3d postWPP  (6792) pupae 4d postWPP  (7488) adult male 01day  (12513) adult male 05day  (12546) adult male 30day  (11497) adult female 01day  (18049) adult female 05day  (19635) adult female 30day  (19091) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  16820 embryo 02-04hr    5620 embryo 04-06hr    8285 embryo 06-08hr    8583 embryo 08-10hr    8674 embryo 10-12hr  11760 embryo 12-14hr    6867 embryo 14-16hr    7453 embryo 16-18hr    8026 embryo 18-20hr    8802 embryo 20-22hr  12237 embryo 22-24hr  11979 larva L1  (21580) larva L2  (24624) larva L3 12hr old  (22602) larva L3 puffstage 1-2    9513 larva L3 puffstage 3-6    7620 larva L3 puffstage 7-9    8063 white prepupae new    7876 white prepupae 12hr    6687 white prepupae 24hr    7663 pupae 2d postWPP    7102 pupae 3d postWPP    6792 pupae 4d postWPP    7488 adult male 01day  12513 adult male 05day  12546 adult male 30day  11497 adult female 01day  18049 adult female 05day  19635 adult female 30day  19091 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    16820 embryo 02-04hr    5620 embryo 04-06hr    8285 embryo 06-08hr    8583 embryo 08-10hr    8674 embryo 10-12hr    11760 embryo 12-14hr    6867 embryo 14-16hr    7453 embryo 16-18hr    8026 embryo 18-20hr    8802 embryo 20-22hr    12237 embryo 22-24hr    11979 larva L1    21580 larva L2    24624 larva L3 12hr old    22602 larva L3 puffstage 1-2    9513 larva L3 puffstage 3-6    7620 larva L3 puffstage 7-9    8063 white prepupae new    7876 white prepupae 12hr    6687 white prepupae 24hr    7663 pupae 2d postWPP    7102 pupae 3d postWPP    6792 pupae 4d postWPP    7488 adult male 01day    12513 adult male 05day    12546 adult male 30day    11497 adult female 01day    18049 adult female 05day    19635 adult female 30day    19091 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0016687    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0016687 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval Malpighian tubules, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0016687 expression level Tissue   Expression Level Larval Central Nervous System    1078.8 Larval Midgut    1514.8 Larval Hindgut    1213.9 Larval Malpighian Tubules    478.6 Larval Fat Body    812.6 Larval Salivary Gland    1993 Larval Trachea    1406.05 Larval Carcass    956.8 Adult Head    1330 Adult Eye    1115.5 Adult Brain    658.5 Adult Thoracic-Abdominal Ganglion    700.5 Adult Crop    1223.7 Adult Midgut    1447.1 Adult Hindgut    1161.6 Adult Malpighian Tubules    1253.2 Adult Fat Body    2232.3 Adult Salivary Gland    1682.3 Adult Heart    2170.225 Adult VirginFemale Spermatheca    2105 Adult InseminatedFemale Spermatheca    1895.4 Adult Ovary    1071.5 Adult Testis    303.7 Adult Male Accessory Gland    1384.7 Adult Carcass    2036.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1078.8) Larval Midgut  (1514.8) Larval Hindgut  (1213.9) Larval Malpighian Tubules    478.6 Larval Fat Body  (812.6) Larval Salivary Gland  (1993) Larval Trachea  (1406.05) Larval Carcass  (956.8) Adult Head  (1330) Adult Eye  (1115.5) Adult Brain  (658.5) Adult Thoracic-Abdominal Ganglion  (700.5) Adult Crop  (1223.7) Adult Midgut  (1447.1) Adult Hindgut  (1161.6) Adult Malpighian Tubules  (1253.2) Adult Fat Body  (2232.3) Adult Salivary Gland  (1682.3) Adult Heart  (2170.225) Adult VirginFemale Spermatheca  (2105) Adult InseminatedFemale Spermatheca  (1895.4) Adult Ovary  (1071.5) Adult Testis    303.7 Adult Male Accessory Gland  (1384.7) Adult Carcass  (2036.7) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (1078.8) Larval Midgut  (1514.8) Larval Hindgut  (1213.9) Larval Malpighian Tubules    478.6 Larval Fat Body    812.6 Larval Salivary Gland  (1993) Larval Trachea  (1406.05) Larval Carcass    956.8 Adult Head  (1330) Adult Eye  (1115.5) Adult Brain    658.5 Adult Thoracic-Abdominal Ganglion    700.5 Adult Crop  (1223.7) Adult Midgut  (1447.1) Adult Hindgut  (1161.6) Adult Malpighian Tubules  (1253.2) Adult Fat Body  (2232.3) Adult Salivary Gland  (1682.3) Adult Heart  (2170.225) Adult VirginFemale Spermatheca  (2105) Adult InseminatedFemale Spermatheca  (1895.4) Adult Ovary  1071.5 Adult Testis    303.7 Adult Male Accessory Gland  (1384.7) Adult Carcass  (2036.7) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1078.8 Larval Midgut    1514.8 Larval Hindgut    1213.9 Larval Malpighian Tubules    478.6 Larval Fat Body    812.6 Larval Salivary Gland    1993 Larval Trachea    1406.05 Larval Carcass    956.8 Adult Head    1330 Adult Eye    1115.5 Adult Brain    658.5 Adult Thoracic-Abdominal Ganglion    700.5 Adult Crop    1223.7 Adult Midgut    1447.1 Adult Hindgut    1161.6 Adult Malpighian Tubules    1253.2 Adult Fat Body    2232.3 Adult Salivary Gland    1682.3 Adult Heart    2170.225 Adult VirginFemale Spermatheca    2105 Adult InseminatedFemale Spermatheca    1895.4 Adult Ovary    1071.5 Adult Testis    303.7 Adult Male Accessory Gland    1384.7 Adult Carcass    2036.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0016687 expression level Tissue   Expression Level Larval Central Nervous System    1078.8 Larval Midgut    1514.8 Larval Hindgut    1213.9 Larval Malpighian Tubules    478.6 Larval Fat Body    812.6 Larval Salivary Gland    1993 Larval Trachea    1406.05 Larval Carcass    956.8 Adult Head    1330 Adult Eye    1115.5 Adult Brain    658.5 Adult Thoracic-Abdominal Ganglion    700.5 Adult Crop    1223.7 Adult Midgut    1447.1 Adult Hindgut    1161.6 Adult Malpighian Tubules    1253.2 Adult Fat Body    2232.3 Adult Salivary Gland    1682.3 Adult Heart    2170.225 Adult VirginFemale Spermatheca    2105 Adult InseminatedFemale Spermatheca    1895.4 Adult Ovary    1071.5 Adult Testis    303.7 Adult Male Accessory Gland    1384.7 Adult Carcass    2036.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1078.8) Larval Midgut  (1514.8) Larval Hindgut  (1213.9) Larval Malpighian Tubules    478.6 Larval Fat Body  812.6 Larval Salivary Gland  (1993) Larval Trachea  (1406.05) Larval Carcass  (956.8) Adult Head  (1330) Adult Eye  (1115.5) Adult Brain  658.5 Adult Thoracic-Abdominal Ganglion  700.5 Adult Crop  (1223.7) Adult Midgut  (1447.1) Adult Hindgut  (1161.6) Adult Malpighian Tubules  (1253.2) Adult Fat Body  (2232.3) Adult Salivary Gland  (1682.3) Adult Heart  (2170.225) Adult VirginFemale Spermatheca  (2105) Adult InseminatedFemale Spermatheca  (1895.4) Adult Ovary  (1071.5) Adult Testis    303.7 Adult Male Accessory Gland  (1384.7) Adult Carcass  (2036.7) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  1078.8 Larval Midgut  1514.8 Larval Hindgut  1213.9 Larval Malpighian Tubules    478.6 Larval Fat Body    812.6 Larval Salivary Gland  (1993) Larval Trachea  1406.05 Larval Carcass    956.8 Adult Head  1330 Adult Eye  1115.5 Adult Brain    658.5 Adult Thoracic-Abdominal Ganglion    700.5 Adult Crop  1223.7 Adult Midgut  1447.1 Adult Hindgut  1161.6 Adult Malpighian Tubules  1253.2 Adult Fat Body  (2232.3) Adult Salivary Gland  1682.3 Adult Heart  (2170.225) Adult VirginFemale Spermatheca  (2105) Adult InseminatedFemale Spermatheca  (1895.4) Adult Ovary  1071.5 Adult Testis    303.7 Adult Male Accessory Gland  1384.7 Adult Carcass  (2036.7) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1078.8 Larval Midgut    1514.8 Larval Hindgut    1213.9 Larval Malpighian Tubules    478.6 Larval Fat Body    812.6 Larval Salivary Gland    1993 Larval Trachea    1406.05 Larval Carcass    956.8 Adult Head    1330 Adult Eye    1115.5 Adult Brain    658.5 Adult Thoracic-Abdominal Ganglion    700.5 Adult Crop    1223.7 Adult Midgut    1447.1 Adult Hindgut    1161.6 Adult Malpighian Tubules    1253.2 Adult Fat Body    2232.3 Adult Salivary Gland    1682.3 Adult Heart    2170.225 Adult VirginFemale Spermatheca    2105 Adult InseminatedFemale Spermatheca    1895.4 Adult Ovary    1071.5 Adult Testis    303.7 Adult Male Accessory Gland    1384.7 Adult Carcass    2036.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1330   NA  Eye    1115.5   NA  Brain    658.5   1078.8  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    700.5   NA  Crop    1223.7   1514.8  Midgut    1447.1   1213.9  Hindgut    1161.6   478.6  Malpighian Tubules    1253.2   812.6  Fat Body    2232.3   1993  Salivary Gland    1682.3   NA  Heart    2170.225   1406.05  Trachea    NA   NA  VirginFemale Spermatheca    2105   NA  InseminatedFemale Spermatheca    1895.4   NA  Ovary    1071.5   NA  Testis    303.7   NA  Male Accessory Gland    1384.7   956.8  Carcass    2036.7 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_26
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0016687 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4634-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4pnr-MD237 Nurf-38GD1625 lethal | recessive Nurf-38k16102 Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of Nurf-38 Class Mutagen Stocks Known lesion Nurf-38k16102 P-element activity 2 -- Nurf-381 0 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Nurf-38 Class Mutagen Stocks Known lesion Nurf-38GD1625 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Nurf-38GL00369 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Nurf-38JF01299 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Nurf-38KK102637 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Px2 (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Not disrupted in	Df(2R)bwVDe2LPxKR (Spradling et al., 1999, Beaton, 1997.12.27) In(2LR)Px4 (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1625} NA P{KK102637} NA P{TRiP.GL00369} NA P{TRiP.JF01299} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}l(2)SH2046SH2046 No P{lacW}Nurf-38k16102 No
Gene Ontology: Function, Process & Cellular Component ( 11 unique terms )
Terms Based on Experimental Evidence ( 9 terms )
Molecular Function
CV term Evidence References
inorganic diphosphatase activity inferred from direct assay (Gdula et al., 1998)
Biological Process
CV term Evidence References
chromatin remodeling inferred from direct assay (Gdula et al., 1998) ecdysone receptor-mediated signaling pathway inferred from genetic interaction with EcR (Badenhorst et al., 2005) nucleosome mobilization inferred from direct assay (Hamiche et al., 1999) positive regulation of Notch signaling pathway inferred from genetic interaction with N (Kugler and Nagel, 2010) transcription, DNA-dependent inferred from direct assay (Mizuguchi et al., 2001)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Gdula et al., 1998) nucleus inferred from direct assay (Gdula et al., 1998) NURF complex inferred from direct assay AND inferred from physical interaction with Caf1 AND inferred from physical interaction with Iswi (Gdula et al., 1998)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
inorganic diphosphatase activity inferred from sequence or structural similarity with EMBL:AF108211 (FlyBase, 1992-) non-traceable author statement (Spradling et al., 1999, Gdula, 1998.8.20) magnesium ion binding inferred from electronic annotation with InterPro:IPR008162 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
phosphate-containing compound metabolic process inferred from electronic annotation with InterPro:IPR008162 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
cytoplasm non-traceable author statement (Swiss-Prot Project Members, 1998.12.15) nucleus non-traceable author statement (Swiss-Prot Project Members, 1998.12.15) NURF complex non-traceable author statement (Gdula, 1998.8.20, Swiss-Prot Project Members, 1998.12.15) traceable author statement (Badenhorst et al., 2002)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Nurf-38 allele Gene References unspecified EcR (Badenhorst et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63494 DroID - A comprehensive database of gene and protein interactions. • FBgn0016687 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37922
Orthologs
Genome-wide drosophilid orthologs	Dana\GF11243 Dere\GG19918 Dgri\GH21893 Dmoj\GI20392 Dper\GL10109 Dpse\GA25082 Dsec\GM11820 Dsim\GD24942 Dvir\GJ22117 Dwil\GK19471 Dyak\GE11442
Curated drosophilid orthologs	Dpse\GA18319
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL003193-PB Aedes aegypti (mosquito) AGAP003398-PA Anopheles gambiae (mosquito) XP_001951561.1 Acyrthosiphon pisum (pea aphid) At5g09650.1 Arabidopsis thaliana (wall cress) 34968 Batrachochytrium dendrobatidis (chytrid fungus) 256904 Branchiostoma floridae (lancelet) XP_001894848.1 Brugia malayi (roundworm nematode) BGIBMGA007988-PA Bombyx mori (silk worm) ENSBTAP00000003165 Bos taurus (bovine) CAL0006016 Candida albicans (a form of yeast) CN12869 Caenorhabditis brenneri (small nematode) CBP32699 Caenorhabditis briggsae (nematode) CE33768 Caenorhabditis elegans (worm) ENSCAFP00000020696 Canis familiaris (dog) CAGL0H09878g Candida glabrata (haploid yeast) Chro.40159 Cryptosporidium hominis (obligate parasite) ENSCINP00000004762 Ciona intestinalis (sea squirt) JA03038 Caenorhabditis japonica (nematode) CMR255C Cyanidioschyzon merolae (red alga) cn05011 Cryptococcus neoformans (yeast-like fungus) cgd4_1400 Cryptosporidium parvum (protozoan parasite) CPIJ011898 Culex pipens (mosquito) ENSCPOP00000012630 Cavia porcellus (guinea pig) 133620 Chlamidomonas reinhardtii (green alga) RP38036 Caenorhabditis remanei (nematode) ENSCSAVP00000010584 Ciona savignyi (sedentary tunicate) 221412 Capitella spl (polychaete worm) DDB0233791 Dictyostelium discoideum (amoeba) DEHA2B13090g Debaryomyces Hansenii (yeast) 93571 Daphnia pulex (daphnia) ENSDARP00000040408 Danio rerio (zebra fish) ENSECAP00000016423 Equus caballus (horse) XP_649445 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000011516 Gymnopilus aculeatus (mushroom) ENSGALP00000007055 Gallus gallus (chicken) 93282 Hypsipyla robusta (cedar shoot borer) ENSP00000349996 Homo sapiens (human) ISCW000237-PA Ixodes scapularis (deer tick) KLLA0E17667g Kluyveromyces lactis (yeast) 190068 Lottia gigantea (owl limpet) LmjF11.0210 Leishmania major (virus) 37328 Monocosta brevicollis (choanoflagellate) ENSMODP00000025811 Monodelphis domestica (gray opossum) ENSMMUP00000008439 Macaca mulatta (rhesus monkey) ENSMUSP00000029644 Mus musculus (house mouse) 191879 Nematostella vectensis (starlet anemone) XP_001604166.1 Nasonia vitripennis (wasp) ENSOANP00000019245 Ornithorynchus anatinus (platypus) ENSORLP00000008496 Oryzias latipes (japanese killifish) LOC_Os02g52940.1 Oryza sativa (asian rice) 37035 Ostreococcus tauri (green alga) PFC0710w Plasmodium falciparum (protozoal parasite) PHUM003479-PA Pediculus humanus (human body louse) PP26257 Pristionchus pacificus (nematode) 144716 Physcomitrella patens (moss) ENSPPYP00000016724 Pongo pygmaeus (orangutan) 78623 Phytophthora ramorum (sudden oak death pathogen) 135461 Phytophthora sojae (root rot pathogen) 707493 Populus trichocarpa (black cottonwood) ENSPTRP00000046215 Pan troglodytes (chimpanzee) ENSRNOP00000016195 Rattus norvegicus (norway rat) 4758086 Sorghum bicolor (sorghum) YBR011C Saccharomyces cerevisiae (budding yeast) SPAC23C11.05 Schizosaccharomyces pombe (fission yeast) XP_001181161.1 Strongylocentrotus purpuratus (purple sea urchin) 63891 Trichoplax adhaerens (metazoa) TA13735 Theileria annulata (apicomplexan parasite) XP_967051.1 Tribolium castaneum (red flour beetle) Tc00.1047053503613.60 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511165.40 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000008279 Tetraodon nigroviridis (green spotted pufferfish) ENSTNIP00000011481 Tetraodon nigroviridis (green spotted pufferfish) TP02_0061 Theileria parva (parasitic protozoan) 269348 Thalassiosira pseudonana (marine diatom) ENSTRUP00000032449 Takifugu rubripes (pufferfish Takifugu) 7.m00505 Tetrahymena thermophila (ciliate protozoa) 80654.m00029 Trichomonas vaginalis (parasitic flagellated protozoan) 80892.m00184 Trichomonas vaginalis (parasitic flagellated protozoan) 96647.m00117 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000013520 Xenopus tropicalis (frog) YALI0F13541g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14884 LH19394 ISCW000237 FBgn0229247 FBgn0221469 FBgn0209231 FBgn0196256 FBgn0166762 JGI_V11_93571 FBgn0246465 FBgn0147719 FBgn0143128 FBgn0129354 FBgn0112118 FBgn0088283 CPIJ011898 BGIBMGA007988 ACYPI006609 ACYPI003262 GB18261 AGAP003398 AAEL003193 PB22354 PHUM596830 GLEAN_04566
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	31341 y1 v1; P{TRiP.JF01299}attP2 35444 y1 sc* v1; P{TRiP.GL00369}attP2 12206 y1 w67c23; P{lacW}Nurf-38k16102/CyO
Kyoto	111452 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{neoFRT}42D P{lacW}Nurf-38k16102 /CyO y+
VDRC	v103776 P{KK102637}VIE-260B v3200 w1118; P{GD1625}v3200/TM3
Genomic Clones ( 1 )
	BACR11C07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 306 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE37074
Other clones	MIP03147
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT04948 GH01050 GH03433 GH07041 GH12979 GH13179 GH13487 GH19883 GH22669 GH25857 GH27041 GM05431 GM05864 GM27206 GM27256 LD20263 LD20275 LD20754 LP03782 LP04320 LP13124 LP19403 LP21376 LP21783 RE05266 RE14772 RE22414 RE31050 RE36830 RE39403 RE61678 RE71938 RE73207 RH21639 RH24095 RH35272 RH35661 RH37006 RH37176 RH40537 RH47691 RH52532 RH55914 RH59060 SD14413
Other clones	19767 108592 173996 192719 562154 Dmel_dig_006753_0697_1848 Dmel_dig_011674_0688_3360 Dmel_dig_012347_0603_0781 Dmel_dig_015603_0641_2480 Dmel_dig_017465_0677_2779 Dmel_dig_019699_0622_1221 Dmel_dig_021211_0716_2414 Dmel_neb_003305_0381_3301 Dmel_neb_011422_0324_2377 EC052211 EC052673 EC053167 EC053715 EC054649 EC055604 EC056562 EK133164 EK278458 EK290414 EK296357 EN13824 FGM307F04 GH06031 IP05328 IP12169 IP12269 IP17531 RP003007120 RP003007516 RP003012564 RP003015596 RP003016162 RP003017420 RP003019538 RP003023602 RP003024935 RP003025539 RP003029269 RP003030339 RP003035753 RP003036557 RP003040138 RP003042801 RP003043156 RP003044427 RP003051757 RP003057241 RP003058203 RP003059540 RP003061160 RP003065144 RP003066311 RP003066779 RP003068233 RP003068429 RP003069642 RP003072368 RP003082803 RP003082863 RP003083681 RP003084092 RP003084397 RP003087989 RP003096883 RP003097940 RP003098924 RP003100212 RP003104957 RP003107835 RP003117811 RP003120367 RP003120807 RP003121268 RP003126568 RP003128228 RP003130081 RP003130534 RP003134209 RP003137861 RP003139001 RP003139027 RP003139137 RP003139179 RP003143103 RP003146581 RP003146757 RP003149908 RP003156384 RP003157248 RP003159830 RP003160526 RP003162709 RP003164554 RP003167527 RP003171139 RP003173620 RP003175661 RP003176004 RP003179372 RP003179455 RP003180129 RP003186658 RP003191593 RP003197673 RP003197767 RP003200635 RP003203358 RP003204457 RP003205609 RP003205735 RP003205954 RP003209799 RP003211363 RP003211987 RP003213675 RP003220546 RP003222076 RP003222593 RP003223787 RP003224254 RP003225169 RP003225370 RP003225806 RP003235744 RP003235833 RP003237182 RP003237540 RP003239928 RP003248878 RP003249512 RP003249536 RP003260198 RP003261140 RP003265865 RP003281054 RP003282978 RP003294200 RP003300650 RP003302387 RP003309222 RP003319840 RP003321798 RP003322338 RP003323378 RP003330441 RP003330593 RP003334747 RP003336251 RP003340312 RP003346801 RP003349205 RP003349503 RP003352562 RP003354780 RP003356317 RP003358510 RP003360589 RP003361298 RP003379236 RP003379565 RP003379977 RP003381525 RP003384344 RP003384742 RP003391972 RP003396331 RP003398359 RP003401621 RP003405143 RP003407508 RP003413930 RP003418205 RP003419013 RP003425197 RP003426981 RP003433287 RP003434169 RP003435372 RP003436026 RP003438762 RP003441259 RP003446472 RP003446958 RP003446987 RP003450810 RP003451259 RP003453321 RP003458766 RP003459288 RP003466065 RP003477927 RP003481934 RP003488501 RP003492488 RP003495776 RP003496983 RP003503275 RP003507244 RP003513182 RP003515307 RP003519420 RP003520165 RP003525581 RP003526582 RP003527751 RP003530744 RP003542938 RP003548526 RP003549091 RP003550018 RP003552819 RP003553133 RP003556366 RP003558297 RP003558521 RP003559690 RP003561301 RP003566213 RP003567726 RP003568913 RP003569697 RP003573855 RP003577394 RP003577695 RP003584947 RP003586415 RP003591294 RP003592432 RP003599579 RP003600086 RP003612356 RP003618087 RP003620592 RP003634507 RP003635803 RP003641267 RP003643756 RP003646430 RP003647636 RP003648026 RP003650251 RP003650536 RP003651641 RP003654065 RP003655182 RP003656251 RP003659518 RP003663242 RP003667838 RP003668562 RP003672542 RP003677919 RP003682125 UUGC0403
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0016687 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37922
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Nurf-38 CG4634 (Wang, 1999.11)
Source for database merge of	Source for merge of: Nurf-38 l(2)k16102 (Spradling et al., 1999)
Additional comments
Other Comments
	Area matching Drosophila EST AI062013. This EST matches Drosophila gene NURF-38. Acc. No. AF085601. (Davies, 2001.3.15) The NURF complex (composed of Caf1, E(bx), Iswi and Nurf-38 proteins) can remodel chromatin and stimulate transcription in vitro irrespective of the acetylation status of histones. (Mizuguchi et al., 2001) Nurf-38 may serve a structural or regulatory role in the nucleosome remodeling factor (NURF) complex. (Gdula et al., 1998) NURF, a protein complex of four subunits Caf1, Nurf-38, E(bx) and Iswi, is able to facilitate transcription mediated by a Scer\GAL4 derivative carrying a constitutively activating region from Hsf. Once nucleosome remodelling by the DNA binding factor is accomplished a high level of NURF activity is not continuously required for recruitment of the general transcription machinery and transcription initiation. NURF is able to assist gene activation in a chromatin context: remodel nucleosomes for gene activation in chromatin. (Mizuguchi et al., 1997) Nucleosome remodelling factor is composed of at least four polypeptides that act in concert with the Trl transcription factor at the Hsp70 promoter. Nucleosome remodelling factor acts directly on the nucleosome to perturb its structure. (Tsukiyama and Wu, 1995)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079125 NM_001144286 RefSeq (Proteins) • NP_523849 NP_001137758 DDBJ / EMBL / GenBank • AAC97111 AAC97112 AAF47227 AAL68291 ACL83211 AF085600 AF085601 AI062013 AQ026097 AX094078 AY075479 BI355998 Entrez Gene - A searchable database of RefSeq genes. • 37922 UniProtKB/Swiss-Prot • O77460
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Inorganic pyrophosphatase (IPR008162)
Linkouts
	BioGRID - A database of protein and genetic interactions • 63494 DroID - A comprehensive database of gene and protein interactions. • FBgn0016687 DRSC - Results from RNAi screens. • FBgn0016687 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0016687 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4634-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0016687 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37922 InParanoid A subset of ortholog calls from InParanoid. • AAEL003193-PB Aedes aegypti (mosquito) AGAP003398-PA Anopheles gambiae (mosquito) XP_001951561.1 Acyrthosiphon pisum (pea aphid) At5g09650.1 Arabidopsis thaliana (wall cress) 34968 Batrachochytrium dendrobatidis (chytrid fungus) 256904 Branchiostoma floridae (lancelet) XP_001894848.1 Brugia malayi (roundworm nematode) BGIBMGA007988-PA Bombyx mori (silk worm) ENSBTAP00000003165 Bos taurus (bovine) CAL0006016 Candida albicans (a form of yeast) CN12869 Caenorhabditis brenneri (small nematode) CBP32699 Caenorhabditis briggsae (nematode) CE33768 Caenorhabditis elegans (worm) ENSCAFP00000020696 Canis familiaris (dog) CAGL0H09878g Candida glabrata (haploid yeast) Chro.40159 Cryptosporidium hominis (obligate parasite) ENSCINP00000004762 Ciona intestinalis (sea squirt) JA03038 Caenorhabditis japonica (nematode) CMR255C Cyanidioschyzon merolae (red alga) cn05011 Cryptococcus neoformans (yeast-like fungus) cgd4_1400 Cryptosporidium parvum (protozoan parasite) CPIJ011898 Culex pipens (mosquito) ENSCPOP00000012630 Cavia porcellus (guinea pig) 133620 Chlamidomonas reinhardtii (green alga) RP38036 Caenorhabditis remanei (nematode) ENSCSAVP00000010584 Ciona savignyi (sedentary tunicate) 221412 Capitella spl (polychaete worm) DDB0233791 Dictyostelium discoideum (amoeba) DEHA2B13090g Debaryomyces Hansenii (yeast) 93571 Daphnia pulex (daphnia) ENSDARP00000040408 Danio rerio (zebra fish) ENSECAP00000016423 Equus caballus (horse) XP_649445 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000011516 Gymnopilus aculeatus (mushroom) ENSGALP00000007055 Gallus gallus (chicken) 93282 Hypsipyla robusta (cedar shoot borer) ENSP00000349996 Homo sapiens (human) ISCW000237-PA Ixodes scapularis (deer tick) KLLA0E17667g Kluyveromyces lactis (yeast) 190068 Lottia gigantea (owl limpet) LmjF11.0210 Leishmania major (virus) 37328 Monocosta brevicollis (choanoflagellate) ENSMODP00000025811 Monodelphis domestica (gray opossum) ENSMMUP00000008439 Macaca mulatta (rhesus monkey) ENSMUSP00000029644 Mus musculus (house mouse) 191879 Nematostella vectensis (starlet anemone) XP_001604166.1 Nasonia vitripennis (wasp) ENSOANP00000019245 Ornithorynchus anatinus (platypus) ENSORLP00000008496 Oryzias latipes (japanese killifish) LOC_Os02g52940.1 Oryza sativa (asian rice) 37035 Ostreococcus tauri (green alga) PFC0710w Plasmodium falciparum (protozoal parasite) PHUM003479-PA Pediculus humanus (human body louse) PP26257 Pristionchus pacificus (nematode) 144716 Physcomitrella patens (moss) ENSPPYP00000016724 Pongo pygmaeus (orangutan) 78623 Phytophthora ramorum (sudden oak death pathogen) 135461 Phytophthora sojae (root rot pathogen) 707493 Populus trichocarpa (black cottonwood) ENSPTRP00000046215 Pan troglodytes (chimpanzee) ENSRNOP00000016195 Rattus norvegicus (norway rat) 4758086 Sorghum bicolor (sorghum) YBR011C Saccharomyces cerevisiae (budding yeast) SPAC23C11.05 Schizosaccharomyces pombe (fission yeast) XP_001181161.1 Strongylocentrotus purpuratus (purple sea urchin) 63891 Trichoplax adhaerens (metazoa) TA13735 Theileria annulata (apicomplexan parasite) XP_967051.1 Tribolium castaneum (red flour beetle) Tc00.1047053503613.60 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511165.40 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000008279 Tetraodon nigroviridis (green spotted pufferfish) ENSTNIP00000011481 Tetraodon nigroviridis (green spotted pufferfish) TP02_0061 Theileria parva (parasitic protozoan) 269348 Thalassiosira pseudonana (marine diatom) ENSTRUP00000032449 Takifugu rubripes (pufferfish Takifugu) 7.m00505 Tetrahymena thermophila (ciliate protozoa) 80654.m00029 Trichomonas vaginalis (parasitic flagellated protozoan) 80892.m00184 Trichomonas vaginalis (parasitic flagellated protozoan) 96647.m00117 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000013520 Xenopus tropicalis (frog) YALI0F13541g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37922 modMine - Data generated by the modENCODE project. • FBgn0016687 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14884 LH19394 ISCW000237 FBgn0229247 FBgn0221469 FBgn0209231 FBgn0196256 FBgn0166762 JGI_V11_93571 FBgn0246465 FBgn0147719 FBgn0143128 FBgn0129354 FBgn0112118 FBgn0088283 CPIJ011898 BGIBMGA007988 ACYPI006609 ACYPI003262 GB18261 AGAP003398 AAEL003193 PB22354 PHUM596830 GLEAN_04566
Synonyms & Secondary IDs ( 18 )
Reported As
Symbol Synonym	38 (Hochheimer and Tjian, 2003) CG4634 (Nakahara et al., 2005, Keleman et al., 2009.8.5, Ni et al., 2008, Reumer et al., 2009, Ni et al., 2011.7.19, Cammarato et al., 2011) dNURF (Emerson, 2002, Fry and Peterson, 2001, Boyer et al., 2000, Peterson, 2000) l(2)k16102 (Beaton, 1997.12.27, BDGP Project Members, 1994-1999, ) N38 (Schuettengruber, 2006) NURF (Varga-Weisz, 2006, Baumann et al., 2003, Shen et al., 2003, Wu, 2001, Ridgway and Almouzni, 2001, Mizuguchi et al., 2001, Jones and Kadonaga, 2000, Farkas et al., 2000, Glass and Rosenfeld, 2000, Tyler and Kadonaga, 1999, Guschin and Wolffe, 1999, Di Croce et al., 1999, Kornberg and Lorch, 1999, Wu et al., 1998, Reinberg et al., 1998, Jacobson and Pillus, 1999, Travers, 1999, John and Workman, 1998, Pollard and Peterson, 1998, Gregory and Horz, 1998, Armstrong and Emerson, 1998, Luger and Richmond, 1998, Mizuguchi et al., 1997, Kadonaga, 1998, Gregory and Horz, 1998, Ito et al., 1997, Tsukiyama and Wu, 1997, Peterson, 1996, Kingston et al., 1996, Wysocka et al., 2006) Nurf38 (Badenhorst et al., 2005, Kugler and Nagel, 2010) NURF38 (Lewis et al., 2004, Xiao et al., 2001, Langst and Becker, 2001) NURF-38 (Hochheimer et al., 2002, Corona et al., 2000, Hamiche et al., 1999, Reumer et al., 2009) Nurf-38 (Garcia-Lopez et al., 2008, Gan et al., 2010, Bandyopadhyay et al., 2006, Wasbrough et al., 2010) Nurf 38 (Kugler and Nagel, 2010) p38 (Schwanbeck et al., 2004, Hochheimer et al., 2002) p38/NURF-38 (Hochheimer et al., 2002)
Name Synonym	Inorganic pyrophosphatase (Creagh et al., 2009) Nucleosome remodeling factor (Kingston et al., 1996) Nucleosome remodeling factor - 38kD (Tsukiyama and Wu, 1995, Cammarato et al., 2011) Nucleosome remodeling factor-38 kDa (Reumer et al., 2009) pyrophosphatase (Eberharter and Becker, 2004)
Secondary FlyBase IDs
	FBgn0021828
References ( 83 )
Generate a list of	All references relating to this gene ( 83 )
List References by type	Research paper  ( 29 ) Supplementary material  ( 8 ) Review  ( 29 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 1 ) FlyBase analysis  ( 1 ) Computer file  ( 2 ) Curated genome annotation  ( 1 ) Patent  ( 1 ) DNA/RNA sequence record  ( 3 ) Protein sequence record  ( 1 ) Conference report  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 3 )
	Cherry and Matunis, 2010, Cell Stem Cell 6(6): 557--567 Epigenetic regulation of stem cell maintenance in the Drosophila testis via the nucleosome-remodeling factor NURF. [FBrf0211111] Gan et al., 2010, Cell Res. 20(7): 763--783 Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq. [FBrf0211191] Kugler and Nagel, 2010, Mol. Biol. Cell 21(19): 3443--3448 A novel Pzg-NURF complex regulates Notch target gene activity. [FBrf0211977] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...