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Gene Dmel\Pdp1

General Information
Symbol	Dmel\Pdp1	Species	D. melanogaster
Name	PAR-domain protein 1	Annotation symbol	CG17888
Feature type	protein_coding_gene	FlyBase ID	FBgn0016694
Gene Model Status	Current	Stock availability	24 publicly available
Also Known As	Pdp1ε, pdp, Pdp-1
Genomic Location
Chromosome (arm)	3L	Recombination map	3-
Cytogenetic map	66A14-66A17	Sequence location	3L:7,805,387..7,860,472 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene PAR-domain protein 1 is referred to in FlyBase by the symbol Dmel\Pdp1 (CG17888, FBgn0016694). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; DNA binding. There is experimental evidence that it is involved in the biological process: growth; circadian rhythm; mitosis; DNA endoreduplication; response to nutrient. 33 alleles are reported. No phenotypic data is available. It has 8 annotated transcripts and 8 annotated polypeptides. Protein features are: Basic leucine zipper; Basic-leucine zipper (bZIP) transcription factor. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 12-24 hour embryonic stages, during early larval stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, adult crop, larval/adult hindgut, adult Malpighian tubules, adult heart, adult fat body, adult salivary gland, adult spermathecae, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1627436_s_at completely aligns to an exonic region common to each of the 7 FlyBase-annotated transcript isoforms of Pdp1. Gene sequence location is 3L:7805387..7860472.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Paquet et al., 2008, PLoS Comput. Biol. 4(2): e38
FB2012_01	References Lamaze et al., 2011, EMBO Rep. 12(6): 549--557 Sequence features HFA08896 HFA11251 BKN29014 Controlled Vocabulary Terms RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 66A14-66A17   Limits computationally determined from genome sequence between P{PZ}l(3)0721708223&P{EP}Rac2EP3118 and P{lacW}Nmtj1C7
Experimentally Determined Cytological Location
Cytogenetic map Notes References 66A12-66A17     (Storti, 1996.6.3) 66A12-66A17   (determined by in situ hybridisation)   (Lin et al., 1997)
Experimentally Determined Recombination Data
Location	3- (Storti, 1996.6.3)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Pdp1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Pdp1-RB FBtr0076776  NM_168235   3978   270 Pdp1-RC FBtr0076782  NM_168239   4746   570 Pdp1-RD FBtr0076780  NM_168237   4702   647 Pdp1-RF FBtr0076775  NM_168233   2831   250 Pdp1-RG FBtr0076777  NM_168236   4020   284 Pdp1-RI FBtr0300499  NM_168234   3864   232 Pdp1-RJ FBtr0300500  NM_168238   4660   633 Pdp1-RK FBtr0306535     6028   270
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Pdp1-PB   FBpp0076491   30.4   270   7.15     NP_729299   AAN12022 Pdp1-PC   FBpp0076497   63.2   570   7.62     NP_729303   AAN12027 Pdp1-PD   FBpp0076495   70.0   647   7.96     NP_729301   AAN12025 Pdp1-PF   FBpp0076490   28.3   250   6.80     NP_729297   AAN12021 Pdp1-PG   FBpp0076492   31.9   284   8.45     NP_729300   AAN12024 Pdp1-PI   FBpp0289726   26.0   232   6.52     NP_729298   AAF50513 Pdp1-PJ   FBpp0289727   68.4   633   7.54     NP_729302   AAN12026 Pdp1-PK   FBpp0297493   30.4   270   7.15
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Basic-leucine zipper (bZIP) transcription factor (IPR004827) Basic leucine zipper (IPR011700)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA568045   AA695471   AA695824   AA696745   AA697559   AA802840   AA803207   AE014296 AAF50513   AE014296 AAN12021   AE014296 AAN12022   AE014296 AAN12024   AE014296 AAN12025   AE014296 AAN12026   AE014296 AAN12027   AF172402 AAB97107   AF172403 AAF04506   AF172404 AAF04507   AF172405 AAF04508   AF172406 AAF04509   AF172407 AAF15506   AF172407 AAF15507   AF172407 AAF15508   AF172407 AAF15509   AF172407 AAF15510   AF172407 AAF15511   AF209903 AAF20153   AI063073   AI063080   AI295881   AI517076   AW941066   AX154857   AY070526 AAL47997   AY775786 AAV48825   BE976820   BH809553   BI228286   BI352167   BI362103   BI585178   BI585670   BI604339   BI606997   BI614843   BI626491   BI627320   BI627806   BI630602   BP556033   BT003285 AAO25043   BT003290 AAO25050   BT012493   CK658368   CL943660   CO152770   CO154862   CO185500   CO196236   CO196266   CO196625   CO261855   CO262482   CO263370   CO264244   CO264461   CO269378   CO269905   CO270002   CO270045   CO271718   CO272434   CO273948   CO282138   CO282148   CO282289   CO285408   CO285805   CO287574   CO287652   CO288206   CO288640   CO289607   CO293173   CO293615   CO294996   CO297641   CO298778   CO301067   CO303594   CO304608   CO304777   CO305869   CO306773   CO310285   CO310489   CO310778   CO310784   CO312564   CO313848   CO315103   CO316675   CO318108   CO319165   CO319628   CO323141   CO323716   CO324558   CO324872   CO329808   CO332865   CO333984   CO339579   CO340188   CO340861   CO343264   CZ466665   CZ470401   CZ472488   CZ472707   CZ473464   CZ474832   CZ475706   CZ478825   CZ485086   CZ485087   CZ486019   CZ486020   CZ486044   CZ486045   DN154126   EC057658   EC059943   EC063338   EC063829   EC065549   EC070972   EC073958   EC074656   EC079587   EC079640   EC079641   EC079642   EC081532   EC086345   EC088433   EC088606   EC090005   EC195030   EC198116   EC199564   EC200142   EC200157   EC200393   EC200500   EC201757   EC202765   EC203953   EC204264   EC204778   EC204843   EC204863   EC205442   EC205580   EC209035   EC210902   EC215787   EC217287   EC217412   EC219010   EC220088   EC222462   EC224627   EC225157   EC227413   EC227959   EC230389   EC230493   EC230700   EC231378   EC231677   EC232142   EC233421   EC235147   EC237693   EC238360   EC238544   EC238990   EC239011   EC239034   EC244887   EC246677   EC249216   EC250316   EC253409   EC254915   EC259245   EC261727   EC264685   EV584284   EV586825
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q24217 Q5U8V5 Q86P99 Q8IQ98 Q8IQ99 Q8SZT1 Q9TVQ4 Q9TVS7 Q9TVY0 Q9TW49 Q7KKI2
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
expression microarray Stage Tissue/Position (including subcellular localization) Reference adult stage   adult head   (Kadener et al., 2006) adult brain   (Kadener et al., 2006) Comment:Pdp1 mRNA levels do not significantly differ between ZT4 and ZT16. in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 9 -- 11   posterior endoderm   (Lin et al., 1997) embryonic stage 11   anterior midgut primordium   (Lin et al., 1997) head mesoderm   (Lin et al., 1997) posterior midgut primordium   (Reddy et al., 2000) embryonic stage 11 -- 12   anterior midgut primordium   (Reddy et al., 2000) embryonic stage 12 -- 14   fused midgut primordium   (Reddy et al., 2000) embryonic Malpighian tubule   (Reddy et al., 2000) somatic muscle primordium   (Reddy et al., 2000) dorsal pharyngeal muscle primordium   (Reddy et al., 2000) embryonic hindgut   (Reddy et al., 2000) embryonic stage 13   myoblast   (Lin et al., 1997) embryonic stage 13 -- 14   presumptive embryonic/larval central nervous system   (Reddy et al., 2000) embryonic stage 14   pharyngeal muscle   (Lin et al., 1997) somatic muscle   (Lin et al., 1997) endoderm of midgut primordium   (Lin et al., 1997) epithelium of hindgut   (Lin et al., 1997) fat body primordium   (Lin et al., 1997, Reddy et al., 2000) midgut constriction 2   (Reddy et al., 2000) embryonic stage 14 -- 15   gastric caecum primordium   (Reddy et al., 2000) embryonic stage 15   embryonic epidermis | segmentally repeated   (Lin et al., 1997) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 17   organism   (Lin et al., 1997) Comment:0-21 hr AEL adult stage | female   ovary   (Lin et al., 1997)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 10 -- 11   anterior midgut primordium   (Reddy et al., 2000) posterior midgut primordium   (Reddy et al., 2000) somatic mesoderm | segmentally repeated of germ band   (Reddy et al., 2000) head mesoderm   (Reddy et al., 2000) embryonic stage 13   embryonic hindgut   (Reddy et al., 2000) embryonic Malpighian tubule   (Reddy et al., 2000) embryonic stage 14   interstitial cell precursor   (Reddy et al., 2000) somatic muscle primordium   (Reddy et al., 2000) fat body primordium   (Reddy et al., 2000) embryonic stage 14 -- 15   fused midgut primordium | posterior   (Reddy et al., 2000) gastric caecum primordium   (Reddy et al., 2000) embryonic esophagus   (Reddy et al., 2000) embryonic stage 15   pharyngeal muscle   (Reddy et al., 2000) embryonic stage 15 -- 16   embryonic/larval central nervous system   • nucleus (Reddy et al., 2000) embryonic stage 16   embryonic/larval fat body   • nucleus (Reddy et al., 2000) adult stage   s-LNv neuron   (Nitabach et al., 2006) LNd neuron   (Nitabach et al., 2006, Shafer et al., 2006) DN1 neuron   (Nitabach et al., 2006) DN2 neuron   (Nitabach et al., 2006) DN1p neuron   (Shafer et al., 2006)
Additional Descriptive Data
	Pdp1 is predominantly nuclear at ZT18. (Shafer et al., 2006)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0016694    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0016694 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 12-24 hour embryonic stages, during early larval stages, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0016694 expression level Developmental Stage   Expression Level embryo 00-02hr    61 embryo 02-04hr    43 embryo 04-06hr    153 embryo 06-08hr    424 embryo 08-10hr    777 embryo 10-12hr    937 embryo 12-14hr    1538 embryo 14-16hr    2505 embryo 16-18hr    1870 embryo 18-20hr    1776 embryo 20-22hr    1847 embryo 22-24hr    2390 larva L1    1151 larva L2    1589 larva L3 12hr old    738 larva L3 puffstage 1-2    179 larva L3 puffstage 3-6    112 larva L3 puffstage 7-9    76 white prepupae new    102 white prepupae 12hr    84 white prepupae 24hr    120 pupae 2d postWPP    864 pupae 3d postWPP    690 pupae 4d postWPP    717 adult male 01day    1623 adult male 05day    1543 adult male 30day    1293 adult female 01day    1027 adult female 05day    569 adult female 30day    507 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    61 embryo 02-04hr    43 embryo 04-06hr  (153) embryo 06-08hr  (424) embryo 08-10hr  (777) embryo 10-12hr  (937) embryo 12-14hr  (1538) embryo 14-16hr  (2505) embryo 16-18hr  (1870) embryo 18-20hr  (1776) embryo 20-22hr  (1847) embryo 22-24hr  (2390) larva L1  (1151) larva L2  (1589) larva L3 12hr old  (738) larva L3 puffstage 1-2  (179) larva L3 puffstage 3-6  (112) larva L3 puffstage 7-9    76 white prepupae new  102 white prepupae 12hr    84 white prepupae 24hr  (120) pupae 2d postWPP  (864) pupae 3d postWPP  (690) pupae 4d postWPP  (717) adult male 01day  (1623) adult male 05day  (1543) adult male 30day  (1293) adult female 01day  (1027) adult female 05day  (569) adult female 30day  (507) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    61 embryo 02-04hr    43 embryo 04-06hr    153 embryo 06-08hr    424 embryo 08-10hr    777 embryo 10-12hr    937 embryo 12-14hr  (1538) embryo 14-16hr  (2505) embryo 16-18hr  (1870) embryo 18-20hr  (1776) embryo 20-22hr  (1847) embryo 22-24hr  (2390) larva L1    1151 larva L2  (1589) larva L3 12hr old    738 larva L3 puffstage 1-2    179 larva L3 puffstage 3-6    112 larva L3 puffstage 7-9    76 white prepupae new    102 white prepupae 12hr    84 white prepupae 24hr    120 pupae 2d postWPP    864 pupae 3d postWPP    690 pupae 4d postWPP    717 adult male 01day  (1623) adult male 05day  (1543) adult male 30day    1293 adult female 01day    1027 adult female 05day    569 adult female 30day    507 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    61 embryo 02-04hr    43 embryo 04-06hr    153 embryo 06-08hr    424 embryo 08-10hr    777 embryo 10-12hr    937 embryo 12-14hr    1538 embryo 14-16hr    2505 embryo 16-18hr    1870 embryo 18-20hr    1776 embryo 20-22hr    1847 embryo 22-24hr    2390 larva L1    1151 larva L2    1589 larva L3 12hr old    738 larva L3 puffstage 1-2    179 larva L3 puffstage 3-6    112 larva L3 puffstage 7-9    76 white prepupae new    102 white prepupae 12hr    84 white prepupae 24hr    120 pupae 2d postWPP    864 pupae 3d postWPP    690 pupae 4d postWPP    717 adult male 01day    1623 adult male 05day    1543 adult male 30day    1293 adult female 01day    1027 adult female 05day    569 adult female 30day    507 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    61 embryo 02-04hr    43 embryo 04-06hr    153 embryo 06-08hr    424 embryo 08-10hr    777 embryo 10-12hr    937 embryo 12-14hr    1538 embryo 14-16hr    2505 embryo 16-18hr    1870 embryo 18-20hr    1776 embryo 20-22hr    1847 embryo 22-24hr    2390 larva L1    1151 larva L2    1589 larva L3 12hr old    738 larva L3 puffstage 1-2    179 larva L3 puffstage 3-6    112 larva L3 puffstage 7-9    76 white prepupae new    102 white prepupae 12hr    84 white prepupae 24hr    120 pupae 2d postWPP    864 pupae 3d postWPP    690 pupae 4d postWPP    717 adult male 01day    1623 adult male 05day    1543 adult male 30day    1293 adult female 01day    1027 adult female 05day    569 adult female 30day    507 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0016694 expression level Developmental Stage   Expression Level embryo 00-02hr    61 embryo 02-04hr    43 embryo 04-06hr    153 embryo 06-08hr    424 embryo 08-10hr    777 embryo 10-12hr    937 embryo 12-14hr    1538 embryo 14-16hr    2505 embryo 16-18hr    1870 embryo 18-20hr    1776 embryo 20-22hr    1847 embryo 22-24hr    2390 larva L1    1151 larva L2    1589 larva L3 12hr old    738 larva L3 puffstage 1-2    179 larva L3 puffstage 3-6    112 larva L3 puffstage 7-9    76 white prepupae new    102 white prepupae 12hr    84 white prepupae 24hr    120 pupae 2d postWPP    864 pupae 3d postWPP    690 pupae 4d postWPP    717 adult male 01day    1623 adult male 05day    1543 adult male 30day    1293 adult female 01day    1027 adult female 05day    569 adult female 30day    507 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    61 embryo 02-04hr    43 embryo 04-06hr  (153) embryo 06-08hr  (424) embryo 08-10hr  (777) embryo 10-12hr  (937) embryo 12-14hr  (1538) embryo 14-16hr  (2505) embryo 16-18hr  (1870) embryo 18-20hr  (1776) embryo 20-22hr  (1847) embryo 22-24hr  (2390) larva L1  (1151) larva L2  (1589) larva L3 12hr old  (738) larva L3 puffstage 1-2  (179) larva L3 puffstage 3-6  112 larva L3 puffstage 7-9    76 white prepupae new  102 white prepupae 12hr    84 white prepupae 24hr  120 pupae 2d postWPP  (864) pupae 3d postWPP  (690) pupae 4d postWPP  (717) adult male 01day  (1623) adult male 05day  (1543) adult male 30day  (1293) adult female 01day  (1027) adult female 05day  (569) adult female 30day  (507) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    61 embryo 02-04hr    43 embryo 04-06hr    153 embryo 06-08hr    424 embryo 08-10hr    777 embryo 10-12hr    937 embryo 12-14hr  1538 embryo 14-16hr  (2505) embryo 16-18hr  1870 embryo 18-20hr  1776 embryo 20-22hr  1847 embryo 22-24hr  2390 larva L1    1151 larva L2  1589 larva L3 12hr old    738 larva L3 puffstage 1-2    179 larva L3 puffstage 3-6    112 larva L3 puffstage 7-9    76 white prepupae new    102 white prepupae 12hr    84 white prepupae 24hr    120 pupae 2d postWPP    864 pupae 3d postWPP    690 pupae 4d postWPP    717 adult male 01day  1623 adult male 05day  1543 adult male 30day    1293 adult female 01day    1027 adult female 05day    569 adult female 30day    507 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    61 embryo 02-04hr    43 embryo 04-06hr    153 embryo 06-08hr    424 embryo 08-10hr    777 embryo 10-12hr    937 embryo 12-14hr    1538 embryo 14-16hr    2505 embryo 16-18hr    1870 embryo 18-20hr    1776 embryo 20-22hr    1847 embryo 22-24hr    2390 larva L1    1151 larva L2    1589 larva L3 12hr old    738 larva L3 puffstage 1-2    179 larva L3 puffstage 3-6    112 larva L3 puffstage 7-9    76 white prepupae new    102 white prepupae 12hr    84 white prepupae 24hr    120 pupae 2d postWPP    864 pupae 3d postWPP    690 pupae 4d postWPP    717 adult male 01day    1623 adult male 05day    1543 adult male 30day    1293 adult female 01day    1027 adult female 05day    569 adult female 30day    507 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    61 embryo 02-04hr    43 embryo 04-06hr    153 embryo 06-08hr    424 embryo 08-10hr    777 embryo 10-12hr    937 embryo 12-14hr    1538 embryo 14-16hr    2505 embryo 16-18hr    1870 embryo 18-20hr    1776 embryo 20-22hr    1847 embryo 22-24hr    2390 larva L1    1151 larva L2    1589 larva L3 12hr old    738 larva L3 puffstage 1-2    179 larva L3 puffstage 3-6    112 larva L3 puffstage 7-9    76 white prepupae new    102 white prepupae 12hr    84 white prepupae 24hr    120 pupae 2d postWPP    864 pupae 3d postWPP    690 pupae 4d postWPP    717 adult male 01day    1623 adult male 05day    1543 adult male 30day    1293 adult female 01day    1027 adult female 05day    569 adult female 30day    507 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0016694    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0016694 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, adult crop, larval/adult hindgut, adult Malpighian tubules, adult heart, adult fat body, adult salivary gland, adult spermathecae, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0016694 expression level Tissue   Expression Level Larval Central Nervous System    114.425 Larval Midgut    63.5 Larval Hindgut    146.7 Larval Malpighian Tubules    26.9 Larval Fat Body no informative data Larval Salivary Gland    25.9 Larval Trachea    29.25 Larval Carcass    49.275 Adult Head    382.8 Adult Eye    264.375 Adult Brain    871.4 Adult Thoracic-Abdominal Ganglion    929.4 Adult Crop    185 Adult Midgut    84.7 Adult Hindgut    259.8 Adult Malpighian Tubules    106.1 Adult Fat Body    254.6 Adult Salivary Gland    147 Adult Heart    115.55 Adult VirginFemale Spermatheca    196.1 Adult InseminatedFemale Spermatheca    138.1 Adult Ovary    24.8 Adult Testis    19.9 Adult Male Accessory Gland    91.7 Adult Carcass    202 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    114.425 Larval Midgut    63.5 Larval Hindgut    146.7 Larval Malpighian Tubules    26.9 Larval Fat Body no informative data Larval Salivary Gland    25.9 Larval Trachea    29.25 Larval Carcass    49.275 Adult Head    382.8 Adult Eye    264.375 Adult Brain  (871.4) Adult Thoracic-Abdominal Ganglion  (929.4) Adult Crop    185 Adult Midgut    84.7 Adult Hindgut    259.8 Adult Malpighian Tubules    106.1 Adult Fat Body    254.6 Adult Salivary Gland    147 Adult Heart    115.55 Adult VirginFemale Spermatheca    196.1 Adult InseminatedFemale Spermatheca    138.1 Adult Ovary    24.8 Adult Testis    19.9 Adult Male Accessory Gland    91.7 Adult Carcass    202 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    114.425 Larval Midgut    63.5 Larval Hindgut    146.7 Larval Malpighian Tubules    26.9 Larval Fat Body no informative data Larval Salivary Gland    25.9 Larval Trachea    29.25 Larval Carcass    49.275 Adult Head    382.8 Adult Eye    264.375 Adult Brain    871.4 Adult Thoracic-Abdominal Ganglion    929.4 Adult Crop    185 Adult Midgut    84.7 Adult Hindgut    259.8 Adult Malpighian Tubules    106.1 Adult Fat Body    254.6 Adult Salivary Gland    147 Adult Heart    115.55 Adult VirginFemale Spermatheca    196.1 Adult InseminatedFemale Spermatheca    138.1 Adult Ovary    24.8 Adult Testis    19.9 Adult Male Accessory Gland    91.7 Adult Carcass    202 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    114.425 Larval Midgut    63.5 Larval Hindgut    146.7 Larval Malpighian Tubules    26.9 Larval Fat Body no informative data Larval Salivary Gland    25.9 Larval Trachea    29.25 Larval Carcass    49.275 Adult Head    382.8 Adult Eye    264.375 Adult Brain    871.4 Adult Thoracic-Abdominal Ganglion    929.4 Adult Crop    185 Adult Midgut    84.7 Adult Hindgut    259.8 Adult Malpighian Tubules    106.1 Adult Fat Body    254.6 Adult Salivary Gland    147 Adult Heart    115.55 Adult VirginFemale Spermatheca    196.1 Adult InseminatedFemale Spermatheca    138.1 Adult Ovary    24.8 Adult Testis    19.9 Adult Male Accessory Gland    91.7 Adult Carcass    202 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0016694 expression level Tissue   Expression Level Larval Central Nervous System    114.425 Larval Midgut    63.5 Larval Hindgut    146.7 Larval Malpighian Tubules    26.9 Larval Fat Body no informative data Larval Salivary Gland    25.9 Larval Trachea    29.25 Larval Carcass    49.275 Adult Head    382.8 Adult Eye    264.375 Adult Brain    871.4 Adult Thoracic-Abdominal Ganglion    929.4 Adult Crop    185 Adult Midgut    84.7 Adult Hindgut    259.8 Adult Malpighian Tubules    106.1 Adult Fat Body    254.6 Adult Salivary Gland    147 Adult Heart    115.55 Adult VirginFemale Spermatheca    196.1 Adult InseminatedFemale Spermatheca    138.1 Adult Ovary    24.8 Adult Testis    19.9 Adult Male Accessory Gland    91.7 Adult Carcass    202 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    114.425 Larval Midgut    63.5 Larval Hindgut    146.7 Larval Malpighian Tubules    26.9 Larval Fat Body no informative data Larval Salivary Gland    25.9 Larval Trachea    29.25 Larval Carcass    49.275 Adult Head    382.8 Adult Eye    264.375 Adult Brain  (871.4) Adult Thoracic-Abdominal Ganglion  (929.4) Adult Crop    185 Adult Midgut    84.7 Adult Hindgut    259.8 Adult Malpighian Tubules    106.1 Adult Fat Body    254.6 Adult Salivary Gland    147 Adult Heart    115.55 Adult VirginFemale Spermatheca    196.1 Adult InseminatedFemale Spermatheca    138.1 Adult Ovary    24.8 Adult Testis    19.9 Adult Male Accessory Gland    91.7 Adult Carcass    202 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    114.425 Larval Midgut    63.5 Larval Hindgut    146.7 Larval Malpighian Tubules    26.9 Larval Fat Body no informative data Larval Salivary Gland    25.9 Larval Trachea    29.25 Larval Carcass    49.275 Adult Head    382.8 Adult Eye    264.375 Adult Brain    871.4 Adult Thoracic-Abdominal Ganglion    929.4 Adult Crop    185 Adult Midgut    84.7 Adult Hindgut    259.8 Adult Malpighian Tubules    106.1 Adult Fat Body    254.6 Adult Salivary Gland    147 Adult Heart    115.55 Adult VirginFemale Spermatheca    196.1 Adult InseminatedFemale Spermatheca    138.1 Adult Ovary    24.8 Adult Testis    19.9 Adult Male Accessory Gland    91.7 Adult Carcass    202 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    114.425 Larval Midgut    63.5 Larval Hindgut    146.7 Larval Malpighian Tubules    26.9 Larval Fat Body no informative data Larval Salivary Gland    25.9 Larval Trachea    29.25 Larval Carcass    49.275 Adult Head    382.8 Adult Eye    264.375 Adult Brain    871.4 Adult Thoracic-Abdominal Ganglion    929.4 Adult Crop    185 Adult Midgut    84.7 Adult Hindgut    259.8 Adult Malpighian Tubules    106.1 Adult Fat Body    254.6 Adult Salivary Gland    147 Adult Heart    115.55 Adult VirginFemale Spermatheca    196.1 Adult InseminatedFemale Spermatheca    138.1 Adult Ovary    24.8 Adult Testis    19.9 Adult Male Accessory Gland    91.7 Adult Carcass    202 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    382.8   NA  Eye    264.375   NA  Brain    871.4   114.425  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    929.4   NA  Crop    185   63.5  Midgut    84.7   146.7  Hindgut    259.8   26.9  Malpighian Tubules    106.1   no informative data  Fat Body    254.6   25.9  Salivary Gland    147   NA  Heart    115.55   29.25  Trachea    NA   NA  VirginFemale Spermatheca    196.1   NA  InseminatedFemale Spermatheca    138.1   NA  Ovary    24.8   NA  Testis    19.9   NA  Male Accessory Gland    91.7   49.275  Carcass    202 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_09
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0016694 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17888-RF
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4pnr-MD237 Pdp1GD4606 lethal | larval stage Pdp1qq lethal | larval stage | recessive Pdp1P205 lethal | pupal stage Pdp1qq lethal | recessive Pdp1P205 viable Pdp13135 Pdp1CB02246 Pdp1EY14882 Sterility Allele fertile Pdp1EY14882 Other Phenotypes Allele circadian behavior defective (with Pdp13135) Pdp1d11071 circadian behavior defective (with Pdp1d11071) Pdp13135 circadian behavior defective | recessive Pdp13135 Pdp1d11071 developmental rate defective Pdp1qq developmental rate defective | recessive Pdp1P205 mitotic cell cycle defective | cell non-autonomous | recessive Pdp1P205 small body Pdp1qq small body | larval stage | recessive Pdp1P205 Phenotype manifest in Allele
Classical Alleles ( 29 )
For All Classical Alleles Show
Allele of Pdp1 Class Mutagen Stocks Known lesion Pdp1KG09201 2 -- Pdp15-HA-2370 1 -- Pdp15-HA-2743 1 -- Pdp1c00705 piggyBac transposase 1 -- Pdp1c04720 1 -- Pdp1c05980 piggyBac transposase 1 -- Pdp1d01879 P-element activity 1 -- Pdp1d05953 P-element activity 1 -- Pdp1d11071 1 -- Pdp1DG12607 1 -- Pdp1e00997 piggyBac transposase 1 -- Pdp1EP3389 P-element activity 1 -- Pdp1f02559 piggyBac transposase 1 -- Pdp1f03452 piggyBac transposase 1 -- Pdp1f03478 piggyBac transposase 1 -- Pdp1KG06888 P-element activity 1 -- Pdp1KG06937 1 -- Pdp1MI01532 1 -- Pdp1NP4632 1 -- Pdp1P205 loss of function allele P-element activity 1 Yes Pdp13135 ethyl methanesulfonate 0 Yes Pdp17A 0 -- Pdp1CB02246 P-element activity 0 Yes Pdp1d02259 P-element activity 0 -- Pdp1d03616 P-element activity 0 -- Pdp1d07394 P-element activity 0 -- Pdp1EY14882 P-element activity 0 -- Pdp1f03451 piggyBac transposase 0 -- Pdp1qq ethyl methanesulfonate 0 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Pdp1 Class Mutagen Stocks Known lesion Pdp1GD4606 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Pdp1JF02110 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Pdp1KK109014 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Pdp1Scer\UAS.cZa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)BSC375 (Christensen et al., 2007.10.29) Df(3L)BSC388 (Christensen et al., 2007.10.29) Df(3L)BSC459 (Christensen et al., 2008.4.15) Df(3L)BSC631 (Christensen et al., 2008.10.20) Df(3L)BSC807 (Christensen et al., 2009.6.15)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data reporter construct P{Pdp1-lacZ.4.4} No P{Pdp1-lacZ.11} No UAS construct P{GD4606} NA P{KK109014} NA P{TRiP.JF02110} NA P{UAS-Pdp1.RD} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Pdp1EP3389 NA P{EPgy2}Pdp1EY14882 NA P{GSV1}C38C38 NA P{XP}Pdp1d01879 NA P{XP}Pdp1d02259 NA P{XP}Pdp1d03616 NA P{XP}Pdp1d05953 NA P{XP}Pdp1d07394 NA P{XP}Pdp1d11071 NA miscellaneous insertions Mi{MIC}Pdp1MI01532 NA P{PTT-GB}Pdp1CB02246 NA P{RS5}Pdp15-HA-2370 NA P{RS5}Pdp15-HA-2743 NA P{SUPor-P}Pdp1KG06888 NA P{SUPor-P}Pdp1KG06937 NA P{SUPor-P}Pdp1KG09201 NA P{wHy}Pdp1DG12607 NA PBac{PB}Pdp1c00705 NA PBac{PB}Pdp1c04720 NA PBac{PB}Pdp1c05980 NA PBac{RB}Pdp1e00997 NA PBac{WH}Pdp1f02559 NA PBac{WH}Pdp1f03451 NA PBac{WH}Pdp1f03452 NA PBac{WH}Pdp1f03478 NA insertion of enhancer trap binary system P{GawB}Pdp1NP4632 No
Gene Ontology: Function, Process & Cellular Component ( 14 unique terms )
Terms Based on Experimental Evidence ( 8 terms )
Molecular Function
CV term Evidence References
DNA binding inferred from physical interaction with Tm1 (Reddy et al., 2000) RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription inferred from direct assay (Cyran et al., 2003)
Biological Process
CV term Evidence References
circadian rhythm inferred from direct assay AND inferred from genetic interaction with vri AND inferred from mutant phenotype (Cyran et al., 2003) DNA endoreduplication inferred from mutant phenotype (Reddy et al., 2006) growth inferred from mutant phenotype (Reddy et al., 2006) mitosis inferred from mutant phenotype (Reddy et al., 2006) response to nutrient inferred from mutant phenotype (Reddy et al., 2006)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Reddy et al., 2000)
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term Evidence References
protein dimerization activity inferred from electronic annotation with InterPro:IPR011700 (FlyBase Curators et al., 2004-) protein homodimerization activity inferred from sequence or structural similarity (Fassler et al., 2002) sequence-specific DNA binding inferred from electronic annotation with InterPro:IPR004827, InterPro:IPR011700 (FlyBase Curators et al., 2004-) sequence-specific DNA binding transcription factor activity traceable author statement (Reddy et al., 2000)
Biological Process
CV term Evidence References
circadian rhythm traceable author statement (Emery and Reppert, 2004) regulation of transcription, DNA-dependent inferred from electronic annotation with InterPro:IPR004827, InterPro:IPR011700 (FlyBase Curators et al., 2004-) transcription, DNA-dependent traceable author statement (Reddy et al., 2000)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Pdp1 allele Gene References Pdp1P205 vri (Cyran et al., 2003)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 69775 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0016694 DroID - A comprehensive database of gene and protein interactions. • FBgn0016694 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45588
Orthologs
Genome-wide drosophilid orthologs	Dana\GF24150 Dere\GG14935 Dgri\GH23565 Dmoj\GI12193 Dper\GL17823 Dpse\GA28498 Dsec\GM24985 Dsim\GD13032 Dvir\GJ11425 Dwil\GK10510 Dyak\GE20386
Curated drosophilid orthologs	Dmau\Pdp1 (Tao et al., 2003, Tao et al., 2003) Dsim\Pdp1 (Tao et al., 2003, Tao et al., 2003)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AGAP006376-PA Anopheles gambiae (mosquito) XP_001943257.1 Acyrthosiphon pisum (pea aphid) 191793 Hypsipyla robusta (cedar shoot borer) ISCW019431-PA Ixodes scapularis (deer tick) XP_001602868.1 Nasonia vitripennis (wasp) XP_001184864.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001192725.1 Strongylocentrotus purpuratus (purple sea urchin) XP_967069.1 Tribolium castaneum (red flour beetle) ENSTNIP00000015920 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000009216 Takifugu rubripes (pufferfish Takifugu) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18728 NV13265 LH15157 ISCW004978 FBgn0237702 FBgn0212525 FBgn0198683 FBgn0184754 FBgn0179846 FBgn0249858 JGI_V11_102458 FBgn0155426 FBgn0134950 FBgn0131022 FBgn0107189 FBgn0101144 CPIJ014920 BGIBMGA003874 ACYPI000702 GB30508 GB13981 AGAP006376 AAEL005255 PHUM426270 GLEAN_02536
Stocks & Reagents
Stocks Listed in FlyBase ( 24 )
Harvard	- P{XP}Pdp1d01879 - P{XP}Pdp1d05953 - P{XP}Pdp1d11071 - PBac{PB}Pdp1c00705 - PBac{PB}Pdp1c04720 - PBac{PB}Pdp1c05980 - PBac{RB}Pdp1e00997 - PBac{WH}Pdp1f02559 - PBac{WH}Pdp1f03452 - PBac{WH}Pdp1f03478
VDRC	v37769 w1118; P{GD4606}v37769 v37770 w1118; P{GD4606}v37770/CyO
	More stocks available...
Genomic Clones ( 1 )
	BACR34B24 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 149 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH27708 GM02880 GM10395 HL02775
Other clones	DPiM_GM02880
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH02508 GH02520 GM04547 GM06388 GM18155 HL01218 LP09643 LP15247 RE25787 RE46575 RH24655 RH25296 RH44324 RH67449 RH68601 RH69246 RH69662 RH73970
Other clones	245 12276 33693 35483 44417 44423 44653 56607 60188 61618 64291 64440 65371 66201 67102 74404 78666 81118 99919 107961 119432 119500 121975 122246 145373 158643 160089 162183 174505 174694 175130 175437 177385 183488 190865 191093 193654 214243.78 214439.87 214539.74 282961 473634 524193 bs56d01 CK01.6C.E11 CK01.19A.F9 CK01.31B.E9 CK01.38C.G4 CK01.77D.E10 CK01.82D.D11 CK01.85D.G12 CK01.87B.A6 CK01.91B.E2 CK01.107B.F1 CK01.110C.H12 CK01.111B.C4 CK01.113A.G11 CK01.123D.D4 CK01.126D.C5 CK01.170B.H1 Dmel_dig_001746_0707_1621 Dmel_neb_008189_0164_3003 EC205580 EK002321 EK002521 EK006923 EK009815 EK060749 EK066214 EK066405 EK067958 EK069035 EK071449 EK080742 EK085453 EK088344 EK094246 EK096517 EK097111 EK097229 EK104429 EK107201 EK112716 EK138307 EK139304 EK159620 EK159632 EK160143 EK168925 EK170247 EK173841 EK187231 EK189816 EK191234 EK194233 EK195041 EK202004 EK203843 EK208127 EK221003 EK221831 EK222509 EK222519 EK229316 EK234176 EK239112 EK242164 EK245255 EK246202 EK249608 EK252242 EK265626 EK276431 EK279614 EK293917 EK304909 EK308530 EN00412 EN04935 EP02307 EP10158 EP11457 EP16427 FGM301A07 GM08321 RH59875
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0016694 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45588
Antibody Information
	polyclonal (Lim et al., 2007, Reddy et al., 2000)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Pdp1 CG3129 (Zhong, 1999.11)
Source for database merge of	Source for merge of: Pdp1 anon-WO0140519.206 (FlyBase, 1996-) Source for merge of: Pdp1 CG17888 (Bayraktaroglu, 2000.4.17)
Additional comments	Source for merge of Pdp1 anon-WO0140519.206 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	Pdp1 is sensitive to nutritional conditions, with two of its protein isoforms becoming upregulated in response to food withdrawal. (Reddy et al., 2006) Pdp1 is an essential clock gene. Pdp1 and vri, together with Clk, comprise a second feedback loop in the Drosophila clock. (Cyran et al., 2003) Identified as a gene with significant level of mRNA cycling as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day. Showed cycling in Canton S and low expression in Clk mutants in microarray experiments. Identified in S2/cycloheximide assay as a direct target of Clk mediated transcriptional regulation. (McDonald and Rosbash, 2001) Pdp1 is likely to be involved in the transcriptional control of different developmental pathways through the use of differentially expressed Pdp1 isoforms. (Reddy et al., 2000) Pdp1 is involved in regulating expression of Tm2 gene in the somatic body wall and pharyngeal muscles by binding to DNA sequences within the muscle activator that are required for activator function. Results suggest Pdp1 may function as part of a large protein/DNA complex that interacts with Mef2 to regulate muscle gene transcription. Pdp1 may also be involved in terminal differentiation of the midgut endoderm, hindgut and Malpighian tubules, the epidermis and the central nervous system. (Lin et al., 1997) Mutations that eliminate Pdp1 binding eliminate muscle activator function and severely reduce expression of a muscle activator. (Lin et al., 1997)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_168233 NM_168234 NM_168235 NM_168236 NM_168237 NM_168238 NM_168239 RefSeq (Proteins) • NP_729297 NP_729298 NP_729299 NP_729300 NP_729301 NP_729302 NP_729303 DDBJ / EMBL / GenBank • AA568045 AA695471 AA697559 AA802840 AA803207 AAB97107 AAF04506 AAF04507 AAF04508 AAF04509 AAF15506 AAF15507 AAF15508 AAF15509 AAF15510 AAF15511 AAF20153 AAF50513 AAL47997 AAN12021 AAN12022 AAN12024 AAN12025 AAN12026 AAN12027 AAO25043 AAO25050 AAV48825 AF172402 AF172403 AF172404 AF172405 AF172406 AF172407 AF209903 AI517076 AW941066 AX154857 AY070526 AY775786 BH809553 BT003285 BT003290 CL943660 CZ466665 CZ470401 CZ472488 CZ472707 CZ473464 CZ474832 CZ475706 CZ478825 CZ485086 CZ485087 CZ486019 CZ486020 CZ486044 CZ486045 Entrez Gene - A searchable database of RefSeq genes. • 45588 UniProtKB/TrEMBL • Q5U8V5 Q7KKI2 Q8IQ98 Q8IQ99 Q8SZT1 Q9TVQ4 Q9TVS7 Q9TVY0 Q9TW49 Q86P99 Q24217
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Basic-leucine zipper (bZIP) transcription factor (IPR004827) Basic leucine zipper (IPR011700)
Linkouts
	BioGRID - A database of protein and genetic interactions • 69775 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0016694 DroID - A comprehensive database of gene and protein interactions. • FBgn0016694 DRSC - Results from RNAi screens. • FBgn0016694 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0016694 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17888-RF FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0016694 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 432465 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45588 InParanoid A subset of ortholog calls from InParanoid. • AGAP006376-PA Anopheles gambiae (mosquito) XP_001943257.1 Acyrthosiphon pisum (pea aphid) 191793 Hypsipyla robusta (cedar shoot borer) ISCW019431-PA Ixodes scapularis (deer tick) XP_001602868.1 Nasonia vitripennis (wasp) XP_001184864.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001192725.1 Strongylocentrotus purpuratus (purple sea urchin) XP_967069.1 Tribolium castaneum (red flour beetle) ENSTNIP00000015920 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000009216 Takifugu rubripes (pufferfish Takifugu) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /dbzhnsky/pardmp11.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45588 modMine - Data generated by the modENCODE project. • FBgn0016694 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18728 NV13265 LH15157 ISCW004978 FBgn0237702 FBgn0212525 FBgn0198683 FBgn0184754 FBgn0179846 FBgn0249858 JGI_V11_102458 FBgn0155426 FBgn0134950 FBgn0131022 FBgn0107189 FBgn0101144 CPIJ014920 BGIBMGA003874 ACYPI000702 GB30508 GB13981 AGAP006376 AAEL005255 PHUM426270 GLEAN_02536 REDfly - A database of transcriptional regulatory elements. • FBgn0016694
Synonyms & Secondary IDs ( 20 )
Reported As
Symbol Synonym	anon-WO0140519.206   CG17888 (Fassler et al., 2002, Molnar et al., 2006, Perkins et al., 2009.3.31, Hazelett et al., 2009, Keleman et al., 2009.8.5) mel_pdp1 (Paquet et al., 2008) PAR-domain protein 1 (Edwards et al., 2006) pdp (Parrish et al., 2009, Bagheri et al., 2008) pdp1 (Baeg et al., 2005, Schoning and Staiger, 2005, Ringrose et al., 2004, Emery and Reppert, 2004, Stanewsky, 2002, McDonald and Rosbash, 2001, Storti, 1999.7.26, Storti, 1999.7.22, Storti, 1999.7.22, Storti, 1999.7.22, Storti, 1999.7.22, Storti, 1996.6.3, Wohlwill et al., 1998, Wohlwill and Storti, 1997, Hung et al., 2007, Kadener et al., 2008, Kivimäe et al., 2008, Junion et al., 2007, Flaherty et al., 2009, T et al., 2008, Schnorrer et al., 2010, Fathallah-Shaykh et al., 2009) PDP1 (Reddy et al., 2001, Reddy et al., 2000, Cervera et al., 1998, Lin et al., 1997, Lin and Storti, 1997, Reddy et al., 2006, Chen et al., 2011, Harrisingh et al., 2007, Huang et al., 2009, Potthoff and Olson, 2007, Shafer et al., 2006, Wu et al., 2008, Blanchard et al., 2010, Lim et al., 2011) Pdp1 (Mack et al., 2006, Kadener et al., 2006, Christensen et al., 2007.10.29, Christensen et al., 2007.10.29, Buszczak et al., 2007, Baeg et al., 2007, Christensen et al., 2008.4.15, Molnar et al., 2006, Lim et al., 2007, Matsumoto et al., 2007, Christensen et al., 2008.10.20, Boothroyd et al., 2007, Kadener et al., 2007, Benito et al., 2007, Murad et al., 2007, Kadener et al., 2008, Hall, 2003, Christensen et al., 2009.6.15, Zheng et al., 2009, Chatterjee et al., 2010, Kula-Eversole et al., 2010, Nagoshi et al., 2010, Cully et al., 2010, Hazelett et al., 2009, Reddy et al., 2000) Pdp-1 (Kadener et al., 2009, Smolen et al., 2004) Pdp1e (Lamaze et al., 2011) Pdp1ε (Sprinzak, 2005, Looby and Loudon, 2005, Collins et al., 2006, Benito et al., 2010, Cyran et al., 2005, Lim et al., 2007, Lim et al., 2007, Yu and Hardin, 2006, Hardin, 2005, Boothroyd et al., 2007, Lim et al., 2007, Benito et al., 2007, Lim et al., 2011) pdp1ε (Kivimäe et al., 2008, Richier et al., 2008) PDP1ε (Ng et al., 2011)
Name Synonym	PAR-domain protein 1 (Edwards et al., 2006, Boothroyd et al., 2007, Flaherty et al., 2009, Bagheri et al., 2008) PAR-Domain Protein 1 (Lin et al., 1997) PAR DOMAIN PROTEIN 1 (Dunlap, 2006) Par domain protein 1 (Lim et al., 2007, Lim et al., 2007, Lamaze et al., 2011) par domain protein 1 (Kadener et al., 2008, T et al., 2008) PAR domain protein 1 (Zheng et al., 2009) PAR Domain Protein 1 (Reddy et al., 2000) PAR domain protein 1ε (Yu and Hardin, 2006)
Secondary FlyBase IDs
	FBgn0035820 FBgn0044667
References ( 116 )
Generate a list of	All references relating to this gene ( 116 )
List References by type	Research paper  ( 62 ) Supplementary material  ( 2 ) Review  ( 13 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 12 ) Abstract  ( 10 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 6 ) Curated genome annotation  ( 2 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 ) Patent  ( 1 )
Recent research papers ( 13 )
	Chen et al., 2011, Curr. Biol. 21(9): 719--729 QUASIMODO, a Novel GPI-Anchored Zona Pellucida Protein Involved in Light Input to the Drosophila Circadian Clock. [FBrf0213611] Goda et al., 2011, PLoS Genet. 7(7): e1002167 Adult Circadian Behavior in Drosophila Requires Developmental Expression of cycle, But Not period. [FBrf0214302] Lamaze et al., 2011, EMBO Rep. 12(6): 549--557 The E3 ubiquitin ligase CTRIP controls CLOCK levels and PERIOD oscillations in Drosophila. [FBrf0213851] Lim et al., 2011, Nature 470(7334): 399--403 The novel gene twenty-four defines a critical translational step in the Drosophila clock. [FBrf0213059] Ng et al., 2011, Curr. Biol. 21(8): 625--634 Glial cells physiologically modulate clock neurons and circadian behavior in a calcium-dependent manner. [FBrf0213518] Benito et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(6): 2544--2549 The circadian output gene takeout is regulated by Pdp1{varepsilon}. [FBrf0209901] Blanchard et al., 2010, J. Neurosci. 30(17): 5855--5865 The transcription factor Mef2 is required for normal circadian behavior in Drosophila. [FBrf0210652] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Chatterjee et al., 2010, Curr. Biol. 20(4): 300--309 Regulation of Gustatory Physiology and Appetitive Behavior by the Drosophila Circadian Clock. [FBrf0210123] Cully et al., 2010, Mol. Cell. Biol. 30(2): 481--495 A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1. [FBrf0209636] Kula-Eversole et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(30): 13497--13502 Surprising gene expression patterns within and between PDF-containing circadian neurons in Drosophila. [FBrf0211416] Nagoshi et al., 2010, Nat. Neurosci. 13(1): 60--68 Dissecting differential gene expression within the circadian neuronal circuit of Drosophila. [FBrf0209632] Schnorrer et al., 2010, Nature 464(7286): 287--291 Systematic genetic analysis of muscle morphogenesis and function in Drosophila. [FBrf0210226] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...