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Gene Dmel\Rab4

General Information
Symbol	Dmel\Rab4	Species	D. melanogaster
Name	Rab-protein 4	Annotation symbol	CG4921
Feature type	protein_coding_gene	FlyBase ID	FBgn0016701
Gene Model Status	Current	Stock availability	11 publicly available
Also Known As	DmRab4
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	54C9-54C10	Sequence location	2R:13,460,579..13,462,484 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Rab-protein 4 is referred to in FlyBase by the symbol Dmel\Rab4 (CG4921, FBgn0016701). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: GTPase activity. It is reported to be involved in the biological process: endocytosis. 14 alleles are reported. The phenotype of these alleles is annotated with: embryonic/larval glial cell. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Small GTP-binding protein domain; Small GTPase superfamily; Small GTPase superfamily, Rab type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult midgut, larval fat body, adult ovary, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1634386_s_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of Rab4. Gene sequence location is 2R:13460579..13462484.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Yang et al., 2011, Neuron 72(2): 285--299 Sequence features HFA07524 BKN28784
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 54C9-54C10   Limits computationally determined from genome sequence between P{EP}MESR4EP386&P{EP}POSHEP1206 and P{PZ}l(2)1050510505
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Rab4 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Rab4-RA FBtr0086830  NM_166240   1307   213 Rab4-RB FBtr0086829  NM_079053   976   213 Rab4-RC FBtr0086831  NM_206155   1607   213
Additional Transcript Data & Comments
Reported size (kB)	0.807, 0.8 (longest cDNA) (Satoh et al., 1997)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Rab4-PA   FBpp0086009   23.6   213   6.77     NP_725696   AAF57831 Rab4-PB   FBpp0086008   23.6   213   6.77     NP_523777   AAM68480 Rab4-PC   FBpp0089285   23.6   213   6.77     NP_995877   AAS64815
Additional Polypeptide Data & Comments
Reported size (kDa)	197 (aa) (Satoh et al., 1997)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Small GTPase superfamily (IPR001806) Small GTPase superfamily, Rab type (IPR003579) Small GTP-binding protein domain (IPR005225)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA697414   AA735311   AE013599 AAF57831   AE013599 AAM68480   AE013599 AAS64815   AB035670 BAA88243   AI239244   AI387608   AI532763   AI532773   AI533214   AI543294   AW942427   AY118519 AAM49888   BG635567   BG635578   BG635587   BG636587   BI234298   BI243145   BI358258   BI485103   BI487173   BI568693   BI569206   BI569207   BI569632   BI577869   BI589540   BI589692   BI637287   BP545736   BP549305   BP551149   BT044417   CA807710   CO155121   CO177416   CO185368   CO185589   CO189590   CO195118   CO196693   CO265773   CO290150   CO314085   CO322418   CO336737   CZ483733   EC080773   EC205111   EC205840   EC205912   EC214114   EC214425   EC230676   EC233387   EC241589   EC261059   EC266907   EL881476   EV581554
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8MSX0 Q7KY04
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0016701    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0016701 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0016701 expression level Developmental Stage   Expression Level embryo 00-02hr    2788 embryo 02-04hr    1608 embryo 04-06hr    1877 embryo 06-08hr    2158 embryo 08-10hr    2303 embryo 10-12hr    2520 embryo 12-14hr    2477 embryo 14-16hr    1562 embryo 16-18hr    1877 embryo 18-20hr    1808 embryo 20-22hr    1886 embryo 22-24hr    2311 larva L1    1514 larva L2    1552 larva L3 12hr old    1539 larva L3 puffstage 1-2    2204 larva L3 puffstage 3-6    2808 larva L3 puffstage 7-9    3821 white prepupae new    3637 white prepupae 12hr    3219 white prepupae 24hr    3115 pupae 2d postWPP    3298 pupae 3d postWPP    2170 pupae 4d postWPP    1183 adult male 01day    2094 adult male 05day    2138 adult male 30day    1896 adult female 01day    1956 adult female 05day    3037 adult female 30day    2943 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2788) embryo 02-04hr  (1608) embryo 04-06hr  (1877) embryo 06-08hr  (2158) embryo 08-10hr  (2303) embryo 10-12hr  (2520) embryo 12-14hr  (2477) embryo 14-16hr  (1562) embryo 16-18hr  (1877) embryo 18-20hr  (1808) embryo 20-22hr  (1886) embryo 22-24hr  (2311) larva L1  (1514) larva L2  (1552) larva L3 12hr old  (1539) larva L3 puffstage 1-2  (2204) larva L3 puffstage 3-6  (2808) larva L3 puffstage 7-9  (3821) white prepupae new  (3637) white prepupae 12hr  (3219) white prepupae 24hr  (3115) pupae 2d postWPP  (3298) pupae 3d postWPP  (2170) pupae 4d postWPP  (1183) adult male 01day  (2094) adult male 05day  (2138) adult male 30day  (1896) adult female 01day  (1956) adult female 05day  (3037) adult female 30day  (2943) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2788) embryo 02-04hr  (1608) embryo 04-06hr  (1877) embryo 06-08hr  (2158) embryo 08-10hr  (2303) embryo 10-12hr  (2520) embryo 12-14hr  (2477) embryo 14-16hr  (1562) embryo 16-18hr  (1877) embryo 18-20hr  (1808) embryo 20-22hr  (1886) embryo 22-24hr  (2311) larva L1  (1514) larva L2  (1552) larva L3 12hr old  (1539) larva L3 puffstage 1-2  (2204) larva L3 puffstage 3-6  (2808) larva L3 puffstage 7-9  (3821) white prepupae new  (3637) white prepupae 12hr  (3219) white prepupae 24hr  (3115) pupae 2d postWPP  (3298) pupae 3d postWPP  (2170) pupae 4d postWPP    1183 adult male 01day  (2094) adult male 05day  (2138) adult male 30day  (1896) adult female 01day  (1956) adult female 05day  (3037) adult female 30day  (2943) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2788 embryo 02-04hr    1608 embryo 04-06hr    1877 embryo 06-08hr    2158 embryo 08-10hr    2303 embryo 10-12hr    2520 embryo 12-14hr    2477 embryo 14-16hr    1562 embryo 16-18hr    1877 embryo 18-20hr    1808 embryo 20-22hr    1886 embryo 22-24hr    2311 larva L1    1514 larva L2    1552 larva L3 12hr old    1539 larva L3 puffstage 1-2    2204 larva L3 puffstage 3-6    2808 larva L3 puffstage 7-9    3821 white prepupae new    3637 white prepupae 12hr    3219 white prepupae 24hr    3115 pupae 2d postWPP    3298 pupae 3d postWPP    2170 pupae 4d postWPP    1183 adult male 01day    2094 adult male 05day    2138 adult male 30day    1896 adult female 01day    1956 adult female 05day    3037 adult female 30day    2943 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2788 embryo 02-04hr    1608 embryo 04-06hr    1877 embryo 06-08hr    2158 embryo 08-10hr    2303 embryo 10-12hr    2520 embryo 12-14hr    2477 embryo 14-16hr    1562 embryo 16-18hr    1877 embryo 18-20hr    1808 embryo 20-22hr    1886 embryo 22-24hr    2311 larva L1    1514 larva L2    1552 larva L3 12hr old    1539 larva L3 puffstage 1-2    2204 larva L3 puffstage 3-6    2808 larva L3 puffstage 7-9    3821 white prepupae new    3637 white prepupae 12hr    3219 white prepupae 24hr    3115 pupae 2d postWPP    3298 pupae 3d postWPP    2170 pupae 4d postWPP    1183 adult male 01day    2094 adult male 05day    2138 adult male 30day    1896 adult female 01day    1956 adult female 05day    3037 adult female 30day    2943 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0016701 expression level Developmental Stage   Expression Level embryo 00-02hr    2788 embryo 02-04hr    1608 embryo 04-06hr    1877 embryo 06-08hr    2158 embryo 08-10hr    2303 embryo 10-12hr    2520 embryo 12-14hr    2477 embryo 14-16hr    1562 embryo 16-18hr    1877 embryo 18-20hr    1808 embryo 20-22hr    1886 embryo 22-24hr    2311 larva L1    1514 larva L2    1552 larva L3 12hr old    1539 larva L3 puffstage 1-2    2204 larva L3 puffstage 3-6    2808 larva L3 puffstage 7-9    3821 white prepupae new    3637 white prepupae 12hr    3219 white prepupae 24hr    3115 pupae 2d postWPP    3298 pupae 3d postWPP    2170 pupae 4d postWPP    1183 adult male 01day    2094 adult male 05day    2138 adult male 30day    1896 adult female 01day    1956 adult female 05day    3037 adult female 30day    2943 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2788) embryo 02-04hr  (1608) embryo 04-06hr  (1877) embryo 06-08hr  (2158) embryo 08-10hr  (2303) embryo 10-12hr  (2520) embryo 12-14hr  (2477) embryo 14-16hr  (1562) embryo 16-18hr  (1877) embryo 18-20hr  (1808) embryo 20-22hr  (1886) embryo 22-24hr  (2311) larva L1  (1514) larva L2  (1552) larva L3 12hr old  (1539) larva L3 puffstage 1-2  (2204) larva L3 puffstage 3-6  (2808) larva L3 puffstage 7-9  (3821) white prepupae new  (3637) white prepupae 12hr  (3219) white prepupae 24hr  (3115) pupae 2d postWPP  (3298) pupae 3d postWPP  (2170) pupae 4d postWPP  (1183) adult male 01day  (2094) adult male 05day  (2138) adult male 30day  (1896) adult female 01day  (1956) adult female 05day  (3037) adult female 30day  (2943) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2788) embryo 02-04hr  1608 embryo 04-06hr  1877 embryo 06-08hr  2158 embryo 08-10hr  2303 embryo 10-12hr  (2520) embryo 12-14hr  (2477) embryo 14-16hr  1562 embryo 16-18hr  1877 embryo 18-20hr  1808 embryo 20-22hr  1886 embryo 22-24hr  2311 larva L1  1514 larva L2  1552 larva L3 12hr old  1539 larva L3 puffstage 1-2  2204 larva L3 puffstage 3-6  (2808) larva L3 puffstage 7-9  (3821) white prepupae new  (3637) white prepupae 12hr  (3219) white prepupae 24hr  (3115) pupae 2d postWPP  (3298) pupae 3d postWPP  2170 pupae 4d postWPP    1183 adult male 01day  2094 adult male 05day  2138 adult male 30day  1896 adult female 01day  1956 adult female 05day  (3037) adult female 30day  (2943) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2788 embryo 02-04hr    1608 embryo 04-06hr    1877 embryo 06-08hr    2158 embryo 08-10hr    2303 embryo 10-12hr    2520 embryo 12-14hr    2477 embryo 14-16hr    1562 embryo 16-18hr    1877 embryo 18-20hr    1808 embryo 20-22hr    1886 embryo 22-24hr    2311 larva L1    1514 larva L2    1552 larva L3 12hr old    1539 larva L3 puffstage 1-2    2204 larva L3 puffstage 3-6    2808 larva L3 puffstage 7-9    3821 white prepupae new    3637 white prepupae 12hr    3219 white prepupae 24hr    3115 pupae 2d postWPP    3298 pupae 3d postWPP    2170 pupae 4d postWPP    1183 adult male 01day    2094 adult male 05day    2138 adult male 30day    1896 adult female 01day    1956 adult female 05day    3037 adult female 30day    2943 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2788 embryo 02-04hr    1608 embryo 04-06hr    1877 embryo 06-08hr    2158 embryo 08-10hr    2303 embryo 10-12hr    2520 embryo 12-14hr    2477 embryo 14-16hr    1562 embryo 16-18hr    1877 embryo 18-20hr    1808 embryo 20-22hr    1886 embryo 22-24hr    2311 larva L1    1514 larva L2    1552 larva L3 12hr old    1539 larva L3 puffstage 1-2    2204 larva L3 puffstage 3-6    2808 larva L3 puffstage 7-9    3821 white prepupae new    3637 white prepupae 12hr    3219 white prepupae 24hr    3115 pupae 2d postWPP    3298 pupae 3d postWPP    2170 pupae 4d postWPP    1183 adult male 01day    2094 adult male 05day    2138 adult male 30day    1896 adult female 01day    1956 adult female 05day    3037 adult female 30day    2943 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0016701    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0016701 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult midgut, larval fat body, adult ovary, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0016701 expression level Tissue   Expression Level Larval Central Nervous System    514.35 Larval Midgut    336.7 Larval Hindgut    573.7 Larval Malpighian Tubules    1043.6 Larval Fat Body    396.3 Larval Salivary Gland    679 Larval Trachea    592.575 Larval Carcass    391.3 Adult Head    615.6 Adult Eye    941.8 Adult Brain    747.7 Adult Thoracic-Abdominal Ganglion    736.9 Adult Crop    590.6 Adult Midgut    443.4 Adult Hindgut    721.6 Adult Malpighian Tubules    1655 Adult Fat Body    580.9 Adult Salivary Gland    1151 Adult Heart    584.775 Adult VirginFemale Spermatheca    673.5 Adult InseminatedFemale Spermatheca    691.7 Adult Ovary    424.7 Adult Testis    77.3 Adult Male Accessory Gland    1059.3 Adult Carcass    532 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  514.35 Larval Midgut    336.7 Larval Hindgut  (573.7) Larval Malpighian Tubules  (1043.6) Larval Fat Body    396.3 Larval Salivary Gland  (679) Larval Trachea  (592.575) Larval Carcass    391.3 Adult Head  (615.6) Adult Eye  (941.8) Adult Brain  (747.7) Adult Thoracic-Abdominal Ganglion  (736.9) Adult Crop  (590.6) Adult Midgut    443.4 Adult Hindgut  (721.6) Adult Malpighian Tubules  (1655) Adult Fat Body  (580.9) Adult Salivary Gland  (1151) Adult Heart  (584.775) Adult VirginFemale Spermatheca  (673.5) Adult InseminatedFemale Spermatheca  (691.7) Adult Ovary    424.7 Adult Testis    77.3 Adult Male Accessory Gland  (1059.3) Adult Carcass  532 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    514.35 Larval Midgut    336.7 Larval Hindgut    573.7 Larval Malpighian Tubules  1043.6 Larval Fat Body    396.3 Larval Salivary Gland    679 Larval Trachea    592.575 Larval Carcass    391.3 Adult Head    615.6 Adult Eye    941.8 Adult Brain    747.7 Adult Thoracic-Abdominal Ganglion    736.9 Adult Crop    590.6 Adult Midgut    443.4 Adult Hindgut    721.6 Adult Malpighian Tubules  (1655) Adult Fat Body    580.9 Adult Salivary Gland  (1151) Adult Heart    584.775 Adult VirginFemale Spermatheca    673.5 Adult InseminatedFemale Spermatheca    691.7 Adult Ovary    424.7 Adult Testis    77.3 Adult Male Accessory Gland  1059.3 Adult Carcass    532 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    514.35 Larval Midgut    336.7 Larval Hindgut    573.7 Larval Malpighian Tubules    1043.6 Larval Fat Body    396.3 Larval Salivary Gland    679 Larval Trachea    592.575 Larval Carcass    391.3 Adult Head    615.6 Adult Eye    941.8 Adult Brain    747.7 Adult Thoracic-Abdominal Ganglion    736.9 Adult Crop    590.6 Adult Midgut    443.4 Adult Hindgut    721.6 Adult Malpighian Tubules    1655 Adult Fat Body    580.9 Adult Salivary Gland    1151 Adult Heart    584.775 Adult VirginFemale Spermatheca    673.5 Adult InseminatedFemale Spermatheca    691.7 Adult Ovary    424.7 Adult Testis    77.3 Adult Male Accessory Gland    1059.3 Adult Carcass    532 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0016701 expression level Tissue   Expression Level Larval Central Nervous System    514.35 Larval Midgut    336.7 Larval Hindgut    573.7 Larval Malpighian Tubules    1043.6 Larval Fat Body    396.3 Larval Salivary Gland    679 Larval Trachea    592.575 Larval Carcass    391.3 Adult Head    615.6 Adult Eye    941.8 Adult Brain    747.7 Adult Thoracic-Abdominal Ganglion    736.9 Adult Crop    590.6 Adult Midgut    443.4 Adult Hindgut    721.6 Adult Malpighian Tubules    1655 Adult Fat Body    580.9 Adult Salivary Gland    1151 Adult Heart    584.775 Adult VirginFemale Spermatheca    673.5 Adult InseminatedFemale Spermatheca    691.7 Adult Ovary    424.7 Adult Testis    77.3 Adult Male Accessory Gland    1059.3 Adult Carcass    532 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  514.35 Larval Midgut    336.7 Larval Hindgut  573.7 Larval Malpighian Tubules  (1043.6) Larval Fat Body    396.3 Larval Salivary Gland  679 Larval Trachea  592.575 Larval Carcass    391.3 Adult Head  615.6 Adult Eye  (941.8) Adult Brain  747.7 Adult Thoracic-Abdominal Ganglion  736.9 Adult Crop  590.6 Adult Midgut    443.4 Adult Hindgut  721.6 Adult Malpighian Tubules  (1655) Adult Fat Body  580.9 Adult Salivary Gland  (1151) Adult Heart  584.775 Adult VirginFemale Spermatheca  673.5 Adult InseminatedFemale Spermatheca  691.7 Adult Ovary    424.7 Adult Testis    77.3 Adult Male Accessory Gland  (1059.3) Adult Carcass  532 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    514.35 Larval Midgut    336.7 Larval Hindgut    573.7 Larval Malpighian Tubules  1043.6 Larval Fat Body    396.3 Larval Salivary Gland    679 Larval Trachea    592.575 Larval Carcass    391.3 Adult Head    615.6 Adult Eye    941.8 Adult Brain    747.7 Adult Thoracic-Abdominal Ganglion    736.9 Adult Crop    590.6 Adult Midgut    443.4 Adult Hindgut    721.6 Adult Malpighian Tubules  1655 Adult Fat Body    580.9 Adult Salivary Gland  1151 Adult Heart    584.775 Adult VirginFemale Spermatheca    673.5 Adult InseminatedFemale Spermatheca    691.7 Adult Ovary    424.7 Adult Testis    77.3 Adult Male Accessory Gland  1059.3 Adult Carcass    532 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    514.35 Larval Midgut    336.7 Larval Hindgut    573.7 Larval Malpighian Tubules    1043.6 Larval Fat Body    396.3 Larval Salivary Gland    679 Larval Trachea    592.575 Larval Carcass    391.3 Adult Head    615.6 Adult Eye    941.8 Adult Brain    747.7 Adult Thoracic-Abdominal Ganglion    736.9 Adult Crop    590.6 Adult Midgut    443.4 Adult Hindgut    721.6 Adult Malpighian Tubules    1655 Adult Fat Body    580.9 Adult Salivary Gland    1151 Adult Heart    584.775 Adult VirginFemale Spermatheca    673.5 Adult InseminatedFemale Spermatheca    691.7 Adult Ovary    424.7 Adult Testis    77.3 Adult Male Accessory Gland    1059.3 Adult Carcass    532 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    615.6   NA  Eye    941.8   NA  Brain    747.7   514.35  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    736.9   NA  Crop    590.6   336.7  Midgut    443.4   573.7  Hindgut    721.6   1043.6  Malpighian Tubules    1655   396.3  Fat Body    580.9   679  Salivary Gland    1151   NA  Heart    584.775   592.575  Trachea    NA   NA  VirginFemale Spermatheca    673.5   NA  InseminatedFemale Spermatheca    691.7   NA  Ovary    424.7   NA  Testis    77.3   NA  Male Accessory Gland    1059.3   391.3  Carcass    532 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_23
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0016701 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4921-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Rab4GD11472 Other Phenotypes Allele neuroanatomy defective | embryonic stage, with Scer\GAL4elav.PU Rab4SN.Scer\UAS.cTa Phenotype manifest in Allele embryonic/larval glial cell, with Scer\GAL4elav.PU Rab4SN.Scer\UAS.cTa
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Rab4 Class Mutagen Stocks Known lesion Rab4f01260 piggyBac transposase 1 --
Alleles Carried on Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Rab4 Class Mutagen Stocks Known lesion Rab4Q67L.Scer\UAS.P\T.T:Avic\GFP-YFP in vitro construct - amino acid replacement in vitro construct - regulatory fusion in vitro construct - coding region fusion 2 Yes Rab4S22N.Scer\UAS.P\T.T:Avic\GFP-YFP in vitro construct - amino acid replacement in vitro construct - regulatory fusion in vitro construct - coding region fusion 2 Yes Rab4Scer\UAS.P\T.T:Avic\GFP-YFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 2 Yes Rab4GD11472 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Rab4HMS01100 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Rab4KK108784 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Rab4Scer\UAS.T:Disc\RFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 1 Yes Rab4S22N.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes Rab4Scer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Rab4SN.Scer\FRT.Scer\UAS in vitro construct - regulatory fusion 0 Yes Rab4SN.Scer\UAS.cTa 0 -- Rab4SN.Scer\UAS FLPase 0 Yes Rab4Ubi-p63E.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11472} NA P{KK108784} NA P{TRiP.HMS01100} NA P{UAS(FRT.T:Hcri\RFP)Rab4.SN} NA P{UAS(-FRT)Rab4.SN} NA P{UAS-EGFP-Rab4} NA P{UASp-YFP.Rab4.Q67L} NA P{UASp-YFP.Rab4.S22N} NA P{UASp-YFP.Rab4} NA P{UAS-Rab4.S22N} NA P{UAS-Rab4.SN.T} NA P{UAS-Rab4-mRFP} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}CG42239KG09816 NA PBac{WH}Rab4f01260 NA
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
GTPase activity inferred from sequence or structural similarity (Kohno et al., 1994) inferred from sequence or structural similarity with UniProtKB:P20338 (FlyBase, 1992-) GTP binding inferred from electronic annotation with InterPro:IPR001806, InterPro:IPR003579, InterPro:IPR005225 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
endocytosis traceable author statement (Armstrong, 2000) protein transport inferred from electronic annotation with InterPro:IPR003579 (FlyBase Curators et al., 2004-) small GTPase mediated signal transduction inferred from electronic annotation with InterPro:IPR001806, InterPro:IPR003579 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Rab4 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62680 DroID - A comprehensive database of gene and protein interactions. • FBgn0016701 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36992
Orthologs
Genome-wide drosophilid orthologs	Dana\GF11646 Dere\GG21802 Dgri\GH20926 Dmoj\GI18364 Dper\GL11470 Dpse\GA18527 Dsec\GM21805 Dsim\GD11294 Dvir\GJ21435 Dwil\GK10719 Dyak\GE11879
Curated drosophilid orthologs	Dpse\GA18527
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL010430-PA Aedes aegypti (mosquito) AGAP004204-PA Anopheles gambiae (mosquito) 202673 Branchiostoma floridae (lancelet) BGIBMGA006641-PA Bombyx mori (silk worm) ENSBTAP00000046611 Bos taurus (bovine) ENSCAFP00000018020 Canis familiaris (dog) cn05263 Cryptococcus neoformans (yeast-like fungus) cgd8_1040 Cryptosporidium parvum (protozoan parasite) CPIJ010194 Culex pipens (mosquito) ENSCPOP00000012884 Cavia porcellus (guinea pig) ENSCSAVP00000007174 Ciona savignyi (sedentary tunicate) 192455 Capitella spl (polychaete worm) 304304 Daphnia pulex (daphnia) ENSDARP00000020980 Danio rerio (zebra fish) ENSECAP00000003618 Equus caballus (horse) ENSGACP00000012612 Gymnopilus aculeatus (mushroom) ENSGALP00000018038 Gallus gallus (chicken) 186059 Hypsipyla robusta (cedar shoot borer) ENSP00000355651 Homo sapiens (human) ISCW020598-PA Ixodes scapularis (deer tick) 177521 Lottia gigantea (owl limpet) 18358 Monocosta brevicollis (choanoflagellate) ENSMODP00000009869 Monodelphis domestica (gray opossum) ENSMMUP00000023303 Macaca mulatta (rhesus monkey) ENSMUSP00000113886 Mus musculus (house mouse) 236786 Nematostella vectensis (starlet anemone) ENSORLP00000008671 Oryzias latipes (japanese killifish) PHUM000576-PA Pediculus humanus (human body louse) ENSPPYP00000000130 Pongo pygmaeus (orangutan) ENSRNOP00000002052 Rattus norvegicus (norway rat) Smp_055670 Schistosoma mansoni (trematode parasite) SPAC1B3.11c Schizosaccharomyces pombe (fission yeast) XP_791693.2 Strongylocentrotus purpuratus (purple sea urchin) 59761 Trichoplax adhaerens (metazoa) ENSTNIP00000010571 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000030393 Takifugu rubripes (pufferfish Takifugu) 96718.m00100 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000005527 Xenopus tropicalis (frog) YALI0B18788g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • ISCW020598 FBgn0229664 FBgn0212732 FBgn0208561 FBgn0183043 FBgn0176682 JGI_V11_304304 FBgn0078529 FBgn0149079 FBgn0141103 FBgn0128388 FBgn0113980 FBgn0088686 CPIJ010194 BGIBMGA006641 AGAP004204 AAEL010430 PHUM517060
Stocks & Reagents
Stocks Listed in FlyBase ( 11 )
Bloomington	8505 w*; P{UAS-Rab4-mRFP}2 23269 y1 w*; P{UASp-YFP.Rab4}09 9768 y1 w*; P{UASp-YFP.Rab4.S22N}37 9769 y1 w*; P{UASp-YFP.Rab4.S22N}46b 9767 y1 w*; P{UASp-YFP.Rab4}Sap-r32 33757 y1 sc* v1; P{TRiP.HMS01100}attP2 9770 y1 w*; P{UASp-YFP.Rab4.Q67L}fz228 23268 y1 w*; P{UASp-YFP.Rab4.Q67L}JhI-2113
Harvard	- PBac{WH}Rab4f01260
VDRC	v106651 P{KK108784}VIE-260B v24672 w1118; P{GD11472}v24672
Genomic Clones ( 2 )
	BACR12C23 BACR21A09 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 51 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD16736
Other clones	FI09101
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH18176 HL02434 HL03558 RE29980 RE40706 RE44973 RE68380 RE70688 RE71627 RH01742 RH02976 RH03163 RH40359 SD04372 SD04384 SD10011 SD13019 SD13031 SD13042 SD14332 SD19254
Other clones	33279 108385 120632 272647 CK01.3A.F4 CK01.5C.G1 CK01.55D.A4 CK01.89B.D3 Dmel_dig_016276_0608_0908 EC39731 EK007554 EK008819 EK010401 EK044634 EK053417 EK073206 EK143616 EK188105 EK234957 EN05422 EN13137 ESG019a.E21_H09 FGC032H11 FGM004G08 FGM211C04 IP11253 RH01354 SD04964
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0016701 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36992
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	dsRNA has been made from templates generated with primers directed against this gene. (Kouranti et al., 2006) dsRNA made from templates generated with primers directed against Rab4 that is transfected into S2 treated with Listeria monocytogenes reveals Rab4 to be involved in Listeria monocytogenes entry. (Cheng et al., 2005) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079053 NM_166240 NM_206155 RefSeq (Proteins) • NP_523777 NP_725696 NP_995877 DDBJ / EMBL / GenBank • AA735311 AAF57831 AAM49888 AAM68480 AAS64815 AB035670 AW942427 AY118519 BAA88243 CZ483733 Entrez Gene - A searchable database of RefSeq genes. • 36992 UniProtKB/TrEMBL • Q7KY04 Q8MSX0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Small GTPase superfamily (IPR001806) Small GTPase superfamily, Rab type (IPR003579) Small GTP-binding protein domain (IPR005225)
Linkouts
	BioGRID - A database of protein and genetic interactions • 62680 DroID - A comprehensive database of gene and protein interactions. • FBgn0016701 DRSC - Results from RNAi screens. • FBgn0016701 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0016701 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4921-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0016701 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36992 InParanoid A subset of ortholog calls from InParanoid. • AAEL010430-PA Aedes aegypti (mosquito) AGAP004204-PA Anopheles gambiae (mosquito) 202673 Branchiostoma floridae (lancelet) BGIBMGA006641-PA Bombyx mori (silk worm) ENSBTAP00000046611 Bos taurus (bovine) ENSCAFP00000018020 Canis familiaris (dog) cn05263 Cryptococcus neoformans (yeast-like fungus) cgd8_1040 Cryptosporidium parvum (protozoan parasite) CPIJ010194 Culex pipens (mosquito) ENSCPOP00000012884 Cavia porcellus (guinea pig) ENSCSAVP00000007174 Ciona savignyi (sedentary tunicate) 192455 Capitella spl (polychaete worm) 304304 Daphnia pulex (daphnia) ENSDARP00000020980 Danio rerio (zebra fish) ENSECAP00000003618 Equus caballus (horse) ENSGACP00000012612 Gymnopilus aculeatus (mushroom) ENSGALP00000018038 Gallus gallus (chicken) 186059 Hypsipyla robusta (cedar shoot borer) ENSP00000355651 Homo sapiens (human) ISCW020598-PA Ixodes scapularis (deer tick) 177521 Lottia gigantea (owl limpet) 18358 Monocosta brevicollis (choanoflagellate) ENSMODP00000009869 Monodelphis domestica (gray opossum) ENSMMUP00000023303 Macaca mulatta (rhesus monkey) ENSMUSP00000113886 Mus musculus (house mouse) 236786 Nematostella vectensis (starlet anemone) ENSORLP00000008671 Oryzias latipes (japanese killifish) PHUM000576-PA Pediculus humanus (human body louse) ENSPPYP00000000130 Pongo pygmaeus (orangutan) ENSRNOP00000002052 Rattus norvegicus (norway rat) Smp_055670 Schistosoma mansoni (trematode parasite) SPAC1B3.11c Schizosaccharomyces pombe (fission yeast) XP_791693.2 Strongylocentrotus purpuratus (purple sea urchin) 59761 Trichoplax adhaerens (metazoa) ENSTNIP00000010571 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000030393 Takifugu rubripes (pufferfish Takifugu) 96718.m00100 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000005527 Xenopus tropicalis (frog) YALI0B18788g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36992 modMine - Data generated by the modENCODE project. • FBgn0016701 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • ISCW020598 FBgn0229664 FBgn0212732 FBgn0208561 FBgn0183043 FBgn0176682 JGI_V11_304304 FBgn0078529 FBgn0149079 FBgn0141103 FBgn0128388 FBgn0113980 FBgn0088686 CPIJ010194 BGIBMGA006641 AGAP004204 AAEL010430 PHUM517060
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	CG4921 (Lee et al., 2003, Verstreken and Bellen, 2000.9.4, Zhang et al., 2007, Sinka et al., 2008, Keleman et al., 2009.8.5, Ni et al., 2010.12.1, Cammarato et al., 2011) CG 4921 (Dorer et al., 2006) DmRab4 (Pereira-Leal and Seabra, 2001, Pereira-Leal and Seabra, 2001) DRAB4 (Kohno et al., 1994) Rab4 (Kouranti et al., 2006, Sweeney et al., 2006, Sweeney et al., 2006, Bowler et al., 2006, Zhang et al., 2007, Oberegelsbacher et al., 2011, Zhang et al., 2007, Sinka et al., 2008, Dyer et al., 2007, Zheng et al., 2008, Strutt and Strutt, 2008, Stone et al., 2008, Morrison et al., 2008, Haglund et al., 2010, Janssens et al., 2010, Raja et al., 2010, Mottola et al., 2010, Mattie et al., 2010, Uytterhoeven et al., 2011, Rodal et al., 2011, Wu et al., 2005, Yang et al., 2011) rab4 (Silies and Klämbt, 2010, Assaker et al., 2010) RAB4c (Dorer et al., 2006)
Name Synonym	Rab-protein 4 (Cammarato et al., 2011)
Secondary FlyBase IDs
References ( 56 )
Generate a list of	All references relating to this gene ( 56 )
List References by type	Research paper  ( 31 ) Supplementary material  ( 7 ) Review  ( 2 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 2 ) FlyBase analysis  ( 1 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 13 )
	Oberegelsbacher et al., 2011, Europ. J. Cell Biol. 90(8): 620--630 The Drosophila TRPL ion channel shares a Rab-dependent translocation pathway with rhodopsin. [FBrf0213847] Rodal et al., 2011, J. Cell Biol. 193(1): 201--217 A presynaptic endosomal trafficking pathway controls synaptic growth signaling. [FBrf0213353] Uytterhoeven et al., 2011, Cell 145(1): 117--132 Loss of skywalker reveals synaptic endosomes as sorting stations for synaptic vesicle proteins. [FBrf0213384] Yang et al., 2011, Neuron 72(2): 285--299 Nak regulates localization of clathrin sites in higher-order dendrites to promote local dendrite growth. [FBrf0216477] Assaker et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(52): 22558--22563 Spatial restriction of receptor tyrosine kinase activity through a polarized endocytic cycle controls border cell migration. [FBrf0212585] Haglund et al., 2010, Curr. Biol. 20(10): 944--950 Cindr interacts with anillin to control cytokinesis in Drosophila melanogaster. [FBrf0210868] Janssens et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(16): 7323--7328 Direct detection of guidance receptor activity during border cell migration. [FBrf0210632] Mattie et al., 2010, Curr. Biol. 20(24): 2169--2177 Directed Microtubule Growth, +TIPs, and Kinesin-2 Are Required for Uniform Microtubule Polarity in Dendrites. [FBrf0212550] Mottola et al., 2010, Development 137(14): 2353--2364 A novel function for the Rab5 effector Rabenosyn-5 in planar cell polarity. [FBrf0211104] Purvanov et al., 2010, Sci. Signal. 3(136): ra65 A direct and functional interaction between go and rab5 during g protein-coupled receptor signaling. [FBrf0211592] Raja et al., 2010, Mol. Cell 38(6): 827--841 The Nonspecific Lethal Complex Is a Transcriptional Regulator in Drosophila. [FBrf0211222] Silies and Klämbt, 2010, Nat. Neurosci. 13(11): 1357--1364 APC/C(Fzr/Cdh1)-dependent regulation of cell adhesion controls glial migration in the Drosophila PNS. [FBrf0212144] Willis et al., 2010, J. Insect Sci. 10: 66 Microarray Analysis of Juvenile Hormone Response in Drosophila melanogaster S2 cells. [FBrf0211402] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...