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General Information
Symbol
Dmel\fz2
Species
D. melanogaster
Name
frizzled 2
Annotation Symbol
CG9739
Feature Type
FlyBase ID
FBgn0016797
Gene Model Status
Stock Availability
Gene Snapshot
In progress.Contributions welcome.
Also Known As
Dfz2, Dfrz2, fz-2, Dfrizzled2, DFz-2
Key Links
Genomic Location
Cytogenetic map
Sequence location
3L:19,140,975..19,235,373 [-]
Recombination map
3-45
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the G-protein coupled receptor Fz/Smo family. (Q9VVX3)
Summaries
Gene Group (FlyBase)
FRIZZLED-TYPE RECEPTORS -
The frizzled gene family belong to Class F GPCRs. Frizzled GPCRs are characterized by a large N-terminal extracellular domain containing a cysteine-rich ligand-binding domain. The frizzled genes were first identified in Drosophila. Frizzled proteins are receptors for secreted Wnt proteins, as well as other ligands, and also play a critical role in the regulation of cell polarity. Frizzleds function in three distinct signaling pathways - the planar cell polarity pathway, the canonical Wnt/β-catenin pathway, and the Wnt/calcium pathway. (Adapted from FBrf0222139).
Pathway (FlyBase)
Wnt-TCF Signaling Pathway Core Components -
The canonical Wnt signaling pathway is initiated by the binding of a Wnt ligand to a frizzled family receptor on the cell surface. Activation of the pathway leads to the inhibition of cytoplasmic β-catenin (arm) degradation and its subsequent accumulation in the nucleus, where it regulates the transcription of target genes. (Adapted from FBrf0218499 and FBrf0223299).
Protein Function (UniProtKB)
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Required to coordinate the cytoskeletons of epidermal cells to produce a parallel array of cuticular hairs and bristles.
(UniProt, Q9VVX3)
Summary (Interactive Fly)
transmembrane - 7 pass - frizzled family - receptor for Wingless - tissue polarity gene - maturation of a central brain flight circuit in requires Fz2/Ca++ signaling
Gene Model and Products
Number of Transcripts
7
Number of Unique Polypeptides
2

Please see the GBrowse view of Dmel\fz2 or the JBrowse view of Dmel\fz2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.55
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
Gene model reviewed during 5.44
Stop-codon suppression (UGA) postulated; FBrf0216884.
gene_with_stop_codon_read_through ; SO:0000697
Gene model reviewed during 5.45
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Gene model reviewed during 6.02
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0075029
3673
694
FBtr0075028
3839
694
FBtr0112890
5113
694
FBtr0299586
4597
694
FBtr0330194
4345
694
FBtr0330195
4448
806
FBtr0332735
5696
694
Additional Transcript Data and Comments
Reported size (kB)
5.5 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0074796
75.5
694
8.25
FBpp0074795
75.5
694
8.25
FBpp0111803
75.5
694
8.25
FBpp0288861
75.5
694
8.25
FBpp0303227
75.5
694
8.25
FBpp0303228
85.4
806
8.13
FBpp0304981
75.5
694
8.25
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

694 aa isoforms: fz2-PA, fz2-PB, fz2-PC, fz2-PD, fz2-PE, fz2-PG
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)
Interacts with ATP6AP2.
(UniProt, Q9VVX3)
Domain
Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway. The FZ domain is involved in binding with Wnt ligands.
(UniProt, Q9VVX3)
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\fz2 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (26 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
inferred from physical interaction with FLYBASE:Grip; FB:FBgn0029830
inferred from physical interaction with UniProtKB:P09615
inferred from direct assay
(assigned by UniProt )
inferred from physical interaction with FLYBASE:wg; FB:FBgn0284084
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from sequence or structural similarity
inferred from biological aspect of ancestor with PANTHER:PTN000139394
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000139394
(assigned by GO_Central )
Biological Process (16 terms)
Terms Based on Experimental Evidence (15 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:fz; FB:FBgn0001085
inferred from genetic interaction with FLYBASE:arr; FB:FBgn0000119
inferred from direct assay
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:arr; FB:FBgn0000119
inferred from genetic interaction with FLYBASE:fz; FB:FBgn0001085
inferred from physical interaction with FLYBASE:Grip; FB:FBgn0029830
inferred from mutant phenotype
inferred from direct assay
(assigned by UniProt )
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000139394
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000139394
(assigned by GO_Central )
Cellular Component (6 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
colocalizes_with early endosome
inferred from direct assay
colocalizes_with late endosome
inferred from direct assay
inferred from direct assay
inferred from direct assay
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
non-traceable author statement
(assigned by UniProt )
inferred from sequence or structural similarity
inferred from biological aspect of ancestor with PANTHER:PTN000139394
(assigned by GO_Central )
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

Additional Descriptive Data
fz2 transcript is first detected in a stripe at about 15-70% egg length in stage 6 embryos. By stage 8, a segmental expression pattern is visible, and at stage 10, 15 stripes are discernible in the presumptive head, trunk, posterior midgut primordium, in a subset of the cells at the anterior midgut invagination site, and in the procephalic lobe. At stage 12, fz2 expression is strong in the midgut and visceral mesoderm. Starting at stage 9, fz2 is also expressed in the central nervous system (CNS). At the end of embryogenesis, fz2 transcript is present in the CNS, the dorsal vessel, and the hindgut. Northern analysis shows that fz2 transcript is expressed in all developmental stages, with the highest levels during embryogenesis and in late larval and pupal life.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
fz2 protein is uniformly expressed in immature hemocyte precursors of the lymph gland during the first larval instar through mid-second instar. At mid-to-late second instar, fz2 protein expression is down-regulated in maturing hemocytes expressing the hemocyte marker Hml.
fz2 protein was observed in glutamatergic type 1b synaptic boutons at the larval neuromuscular junction. The protein was observed both pre- and post-synaptically although it was enriched in post-synaptic areas and co-localized with dlg1 protein staining.
fz2 protein expression is not detectable by immunolocalization at stage 6 of embryogenesis, when fz2 transcript is first detected. The transcript and protein expression patterns coincide on and after stage 9/10 of embryogenesis. fz2 protein is expressed in the embryonic central nervous system starting at stage 9, and continuing through the rest of embryogenesis. At stage 10, the posterior midgut primordium, and at stages 12-16, the visceral mesoderm, also expresses fz2 protein.
Marker for
 
Subcellular Localization
CV Term
Evidence
References
colocalizes_with early endosome
inferred from direct assay
colocalizes_with late endosome
inferred from direct assay
inferred from direct assay
inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\fz2 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 51 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 58 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of fz2
Transgenic constructs containing regulatory region of fz2
Deletions and Duplications ( 3 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
axon & dorsal cluster neuron
chaeta | ectopic & wing, with Scer\GAL4bbg-C96
mitochondrion & bouton, with Scer\GAL4C57
wing & macrochaeta, with Scer\GAL469B
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (18)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
14 of 15
Yes
Yes
 
12 of 15
Yes
No
2 of 15
Yes
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
 
2 of 15
Yes
No
2 of 15
Yes
No
2 of 15
Yes
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (18)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
14 of 15
Yes
Yes
14 of 15
Yes
Yes
 
2 of 15
Yes
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
 
2 of 15
No
No
 
2 of 15
No
No
 
2 of 15
No
No
2 of 15
Yes
No
2 of 15
No
Yes
2 of 15
Yes
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
 
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Rattus norvegicus (Norway rat) (18)
11 of 13
Yes
Yes
10 of 13
No
Yes
5 of 13
No
Yes
2 of 13
No
Yes
2 of 13
No
No
 
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
 
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (20)
11 of 12
Yes
Yes
11 of 12
Yes
Yes
2 of 12
No
Yes
2 of 12
No
Yes
2 of 12
No
Yes
1 of 12
No
No
1 of 12
No
No
1 of 12
No
Yes
1 of 12
No
No
1 of 12
No
No
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
No
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
No
1 of 12
No
Yes
Danio rerio (Zebrafish) (24)
13 of 15
Yes
Yes
13 of 15
Yes
Yes
9 of 15
No
Yes
2 of 15
Yes
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
Yes
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (5)
12 of 15
Yes
Yes
2 of 15
No
Yes
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (4)
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091903VA )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915022Z )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0EHP )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0EGU )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0N5M )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (6)
4 of 10
4 of 10
3 of 10
2 of 10
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 2 )
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    RNA-protein
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Subunit Structure (UniProtKB)
    Interacts with ATP6AP2.
    (UniProt, Q9VVX3 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    Wnt-TCF Signaling Pathway Core Components -
    The canonical Wnt signaling pathway is initiated by the binding of a Wnt ligand to a frizzled family receptor on the cell surface. Activation of the pathway leads to the inhibition of cytoplasmic β-catenin (arm) degradation and its subsequent accumulation in the nucleus, where it regulates the transcription of target genes. (Adapted from FBrf0218499 and FBrf0223299).
    External Data
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3L
    Recombination map
    3-45
    Cytogenetic map
    Sequence location
    3L:19,140,975..19,235,373 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    75F9-76A3
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (38)
    Genomic Clones (84)
    cDNA Clones (452)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
      Commercially Available Antibodies
       
      Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
      Other Information
      Relationship to Other Genes
      Source for database identify of
      Source for database merge of
      Additional comments
      Other Comments
      Identified as a candidate gene for hypoxia-specific selection (via an experimental evolution paradigm) that is also differentially expressed between control and hypoxia-adapted larvae.
      fz2 is required for normal salivary gland migration in the embryo. It is required in the second phase of salivary gland migration, as the gland moves posteriorly within the embryo.
      wg and its receptors, arr and fz2, undergo endocytic trafficking in wing imaginal disc epithelial cells.
      ChEST reveals this is a target of Mef2.
      The fz2 receptor stimulates wg internalization, while arr targets internalized fz2/wg complexes to a degradative compartment.
      The wg morphogen gradient appears to be established by the cooperative action of fz and Heparan Sulfate Proteoglycan receptors.
      dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
      fz and fz2 function as redundant receptors for wg during embryonic development.
      Mutant embryos lacking maternal fz, zygotic fz and zygotic fz2 show defects in the epidermis, CNS, heart and midgut that are indistinguishable from the defects observed for wg mutants.
      fz and fz2 are required during embryogenesis to maintain epidermal en and wg expression.
      fz and fz2 are functionally redundant and act as the primary receptors for wg protein.
      wg signal transduction is abolished in virtually all cells lacking both fz and fz2 in embryos as well as in imaginal discs.
      fz2, together with dally modulates both short- and long-range activities of wg.
      fz and fz2 play a partially redundant role in wg signalling during neurogenesis.
      dsh functions in both fz and fz2 signalling, but distinct dsh protein domains feature in the two pathways.
      High levels of fz2 protein stabilise wg protein, allowing it to reach cells far from its site of synthesis. The expression of fz2 is repressed by wg signaling, creating a gradient of decreasing wg protein stability moving toward the dorso-ventral boundary. The repression of fz2 is essential for the normal shape of the wg morphogen gradient as well as the response of cells to the wg signal. In contrast to other ligand-receptor relationships where the receptor limits diffusion of the ligand, fz2 broadens the range of wg protein action by protecting it from degradation.
      fz and fz2 function redundantly, downstream of wg and upstream of sgg, in the wg signalling pathway in the establishment of segment polarity in the embryo.
      fz2 and not fz acts in the wg signalling pathway for wing margin development.
      A single dominant negative form of fz or fz2 can block more than one type of Wnt signalling pathway implying that truncated proteins of the Fz family lose some aspect of signaling specificity.
      Casein kinase II (encoded by CkIIα and CkIIβ) phosphorylates dsh in vitro. This phosphorylation is regulated by fz2, implicating a role for Casein kinase II in wg signalling.
      Studies of S2 cells transfected with fz2 demonstrate that fz2 can function as a receptor of wg.
      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 72 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
      KEGG Genes - Molecular building blocks of life in the genomic space.
      KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
      modMine - A data warehouse for the modENCODE project
      SignaLink - A signaling pathway resource with multi-layered regulatory networks.
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyMine - An integrated database for Drosophila genomics
      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Synonyms and Secondary IDs (32)
      Reported As
      Symbol Synonym
      Dfz2
      (Wang et al., 2016, Kleinschmit et al., 2010, Sinenko et al., 2010, Lee et al., 2009, Sinenko et al., 2009, Chung et al., 2007, Inaki et al., 2007, Korolchuk et al., 2007, Madder and Strutt, 2007, Bovolenta et al., 2006, Katanaev and Tomlinson, 2006, Price, 2006, Sato et al., 2006, Cox et al., 2005, Desbordes et al., 2005, Marques, 2005, Bajpai et al., 2004, Chen et al., 2004, Huang and Klein, 2004, Marshall et al., 2004, Tabata and Takei, 2004, Johnston and Sanders, 2003, Ruden and Xiao, 2003, Yamazaki and Yanagawa, 2003, Tomlinson and Strapps, 2002, Buratovich and Wilder, 2001, Kumar and Moses, 2001, Alexander et al., 2000, Baeg and Perrimon, 2000, Christian, 2000, Moline et al., 2000, Nusse, 2000, Rives et al., 2000, Rulifson et al., 2000, Selleck, 2000, Strigini and Cohen, 2000, The and Perrimon, 2000, Ui-Tei et al., 2000, Wu et al., 2000, Anonymous, 1999, Bejsovec, 1999, Bhanot et al., 1999, Boutros and Mlodzik, 1999, Cadigan et al., 1999, Helms et al., 1999, Hsieh et al., 1999, Lin and Perrimon, 1999, Moline et al., 1999, Muller et al., 1999, Sato et al., 1999, Toyama, 1999, Toyama, 1999, Bhat, 1998, Cadigan et al., 1998, Dale, 1998, Jones, 1998, Kennerdell and Carthew, 1998, Martinez Arias, 1998, Perrimon and Nusse, 1998, Yanagawa et al., 1998, Ben-Ze'ev, 1997, Cadigan and Nusse, 1997, Cadigan and Nusse, 1997, Moon et al., 1997, Nusse, 1997, Nusse et al., 1997, Willert et al., 1997, Bhanot, 1996.7.30, Bhanot et al., 1996, Ingham, 1996, Perrimon, 1996, Saras and Heldin, 1996, Wang et al., 1996)
      frizzled 2
      Secondary FlyBase IDs
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        References (420)