FB2020_01, released Feb 12, 2020

Gene: Dmel\Stat92E

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General Information
Symbol
Dmel\Stat92E
Species
D. melanogaster
Name
Signal-transducer and activator of transcription protein at 92E
Annotation Symbol
CG4257
Feature Type
protein_coding_gene
FlyBase ID
FBgn0016917
Gene Model Status
Current
Stock Availability
25 publicly available
Gene Snapshot
Signal-transducer and activator of transcription protein at 92E (Stat92E) encodes a transcription factor that shuttles between the cytosol and nucleus and functions in the JAK/STAT pathway. Its roles include proliferation, growth control, organismal metabolism, cell competition, stem cell self-renewal, immunity and developmental patterning. [Date last reviewed: 2019-03-14]
Other Summaries
Also Known As

STAT, marelle, mrl, D-STAT, Dstat

Key Links
Genomic Location
Cytogenetic map
92F1-92F1
Sequence location
3R:20,535,323..20,552,311 [-]
Recombination map

3-69

RefSeq locus
NT_033777 REGION:20535323..20552311
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the transcription factor STAT family. (Q24151)
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
cytokine receptor binding; DNA-binding transcription activator activity, RNA polymerase II-specific; histone binding; protein binding
Predictions / Assertions
DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II proximal promoter sequence-specific DNA binding
Summaries
Gene Group (FlyBase)
OTHER DNA BINDING DOMAIN TRANSCRIPTION FACTORS -
The Other DNA binding domain transcription factors group is a collection of DNA-binding transcription factors that do not fit into any of the other major domain-based transcription factor groups.
Pathway (FlyBase)
JAK-STAT Signaling Pathway Core Components -
The JAK-STAT signaling pathway is initiated by the binding of an extracellular ligand to a cell surface receptor leading to receptor dimerization and the intracellular activation of a Janus kinase (JAK) family member. JAK phosphorylates cytoplasmic STAT family members which dimerize, translocate into the nucleus and regulate target gene expression. In Drosophila, the core pathway is limited to three ligands (the Unpaired family of cytokines), a single receptor (dome), JAK kinase (hop) and STAT (Stat92E). (Adapted from FBrf0225259).
Protein Function (UniProtKB)
Signal transduction and activation of transcription. Plays an important role in the segmental pattern formation in the early embryo by activating specific stripes of pair rule gene expression. The Janus kinase-STAT pathway is connected to drosophila early development.
(UniProt, Q24151)
Summary (Interactive Fly)

transcription factor - cytoplasmic signal transducing protein - regulates the stripe 3 promoter and the pair rule gene - central to the establishment of planar polarity during Drosophila eye development

Gene Model and Products
Number of Transcripts
11
Number of Unique Polypeptides
7

Please see the GBrowse view of Dmel\Stat92E or the JBrowse view of Dmel\Stat92E for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Stat92E-RB
FBtr0089484
NM_169900
3595
628
Stat92E-RC
FBtr0089485
NM_169899
4008
754
Stat92E-RE
FBtr0089487
NM_206520
3852
754
Stat92E-RF
FBtr0089486
NM_206521
3873
761
Stat92E-RG
FBtr0100457
NM_001014643
3616
635
Stat92E-RH
FBtr0334581
NM_001275828
3830
635
Stat92E-RI
FBtr0334582
NM_001275829
3879
679
Stat92E-RJ
FBtr0334583
NM_001275830
4023
811
Stat92E-RK
FBtr0334584
NM_001275831
4200
818
Stat92E-RL
FBtr0334585
NM_001275832
2917
679
Stat92E-RM
FBtr0334586
NM_001275833
4029
761
Additional Transcript Data and Comments
Reported size (kB)

4.0 (northern blot)

(Hou et al., 1996)

4 (northern blot)

(Yan et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Stat92E-PB
FBpp0088487
71.2
628
6.20
NP_732517
AAN14351
Stat92E-PC
FBpp0088488
85.6
754
6.24
NP_732516
AAN14350
Stat92E-PE
FBpp0088978
85.6
754
6.24
NP_996242
AAF55773
Stat92E-PF
FBpp0088489
86.4
761
6.05
NP_996243
AAS65180
Stat92E-PG
FBpp0099882
72.0
635
5.98
NP_001014643
AAX52969
Stat92E-PH
FBpp0306648
72.0
635
5.98
NP_001262757
AGB96137
Stat92E-PI
FBpp0306649
76.8
679
5.62
NP_001262758
AGB96138
Stat92E-PJ
FBpp0306650
91.8
811
5.63
NP_001262759
AGB96139
Stat92E-PK
FBpp0306651
92.6
818
5.44
NP_001262760
AGB96140
Stat92E-PL
FBpp0306652
76.8
679
5.62
NP_001262761
AGB96141
Stat92E-PM
FBpp0306653
86.4
761
6.05
NP_001262762
AGB96142
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

754 aa isoforms: Stat92E-PC, Stat92E-PE
761 aa isoforms: Stat92E-PF, Stat92E-PM
635 aa isoforms: Stat92E-PG, Stat92E-PH
679 aa isoforms: Stat92E-PI, Stat92E-PL
Additional Polypeptide Data and Comments
Reported size (kDa)

761 (aa); 86 (kD predicted)

(Hou et al., 1996)

754 (aa)

(Yan et al., 1996)
Comments
External Data
Subunit Structure (UniProtKB)

Forms a homodimer or a heterodimer with a related family member.

(UniProt, Q24151)
Post Translational Modification

Tyrosine phosphorylated by hopscotch. Phosphorylation is required for DNA-binding activity and dimerization.

(UniProt, Q24151)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Stat92E using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Gene Ontology (40 terms)
Molecular Function (6 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
cytokine receptor binding
inferred from physical interaction with UniProtKB:M9NE35
(Fisher et al., 2016)
inferred from physical interaction with UniProtKB:Q9VWE0
(Fisher et al., 2016)
DNA-binding transcription activator activity, RNA polymerase II-specific
inferred from direct assay
(Kwon et al., 2000)
histone binding
inferred from direct assay
(Xu et al., 2014)
protein binding
inferred from physical interaction with UniProtKB:A1Z7P5
(Betz et al., 2001)
inferred from physical interaction with FLYBASE:Cdk2; FB:FBgn0004107
(Chen et al., 2003)
inferred from physical interaction with FLYBASE:Cdk4; FB:FBgn0016131
(Chen et al., 2003)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
DNA binding
inferred from sequence or structural similarity with HGNC:11366
(Hou et al., 1996)
inferred from sequence or structural similarity with HGNC:11368
(Hou et al., 1996)
DNA-binding transcription activator activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN000210448
(assigned by GO_Central )
(Gaudet et al., 2011)
RNA polymerase II proximal promoter sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN000210448
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (31 terms)
Terms Based on Experimental Evidence (29 terms)
CV Term
Evidence
References
blastoderm segmentation
inferred from mutant phenotype
(Luo and Dearolf, 2001)
border follicle cell migration
inferred from mutant phenotype
(Jang et al., 2009, Silver and Montell, 2001)
cell dedifferentiation
inferred from expression pattern
(Sheng et al., 2009)
cellular response to lipopolysaccharide
inferred from direct assay
(Kwon et al., 2000)
cellular response to X-ray
inferred from mutant phenotype
(Betz et al., 2008)
defense response
inferred from direct assay
(Kwon et al., 2000)
eye-antennal disc morphogenesis
inferred from mutant phenotype
(Ekas et al., 2006)
germ-line stem cell population maintenance
inferred from mutant phenotype
(Brawley and Matunis, 2004)
hindgut morphogenesis
inferred from mutant phenotype
(Johansen et al., 2003, Li et al., 2003)
larval lymph gland hemopoiesis
inferred from mutant phenotype
(Gao et al., 2009)
inferred from genetic interaction with FLYBASE:bip1; FB:FBgn0026263
(Mondal et al., 2014)
larval somatic muscle development
inferred from mutant phenotype
(Liu et al., 2009)
long-term memory
inferred from mutant phenotype
(Copf et al., 2011)
lymph gland development
inferred from mutant phenotype
(Ferguson and Martinez-Agosto, 2017)
negative regulation of antimicrobial humoral response
inferred from mutant phenotype
(Kim et al., 2007)
inferred from genetic interaction with FLYBASE:Rel; FB:FBgn0014018
(Kim et al., 2007)
negative regulation of stem cell differentiation
inferred from mutant phenotype
(Tarayrah et al., 2015)
nervous system development
inferred from mutant phenotype
(Li et al., 2003)
oocyte localization involved in germarium-derived egg chamber formation
inferred from mutant phenotype
(Torres et al., 2003)
oogenesis
inferred from mutant phenotype
(Torres et al., 2003, Baksa et al., 2002)
open tracheal system development
inferred from mutant phenotype
(Li et al., 2003)
ovarian follicle cell stalk formation
inferred from mutant phenotype
(Torres et al., 2003)
positive regulation of cell population proliferation
inferred from mutant phenotype
(Buchon et al., 2010)
positive regulation of defense response to virus by host
inferred from mutant phenotype
(Avadhanula et al., 2009)
positive regulation of heterochromatin assembly
inferred from mutant phenotype
(Xu et al., 2014)
primary sex determination
inferred from mutant phenotype
(Jinks et al., 2000)
receptor signaling pathway via JAK-STAT
inferred from genetic interaction with FLYBASE:hop; FB:FBgn0004864
(Bailetti et al., 2019, Hou et al., 1996)
inferred from direct assay
(Muller et al., 2005)
inferred from mutant phenotype
(Kallio et al., 2010)
segment specification
inferred from mutant phenotype
(Hombria et al., 2005)
stem cell division
inferred from mutant phenotype
(Tulina and Matunis, 2001)
stem cell population maintenance
inferred from mutant phenotype
(Kiger et al., 2001)
wing disc morphogenesis
inferred from mutant phenotype
(Recasens-Alvarez et al., 2017)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
defense response
inferred from biological aspect of ancestor with PANTHER:PTN000927860
(assigned by GO_Central )
(Gaudet et al., 2011)
positive regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN000210448
(assigned by GO_Central )
(Gaudet et al., 2011)
receptor signaling pathway via JAK-STAT
inferred from biological aspect of ancestor with PANTHER:PTN000927860
(assigned by GO_Central )
(Gaudet et al., 2011)
regulation of cell population proliferation
inferred from biological aspect of ancestor with PANTHER:PTN000927860
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
cytoplasmic side of apical plasma membrane
inferred from direct assay
(Sotillos et al., 2008)
cytosol
inferred from direct assay
(Sotillos et al., 2008, Agaisse et al., 2003)
nucleus
inferred from direct assay
(Sotillos et al., 2008, Agaisse et al., 2003, Kwon et al., 2000)
inferred from direct assay
(assigned by BHF-UCL )
(Li et al., 2009)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
cytosol
inferred from biological aspect of ancestor with PANTHER:PTN000210448
(assigned by GO_Central )
(Gaudet et al., 2011)
nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000210448
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
extended germ band stage
mesoderm
(Yan et al., 1996)
organism | segment polarity expression pattern
(Hou et al., 1996, Yan et al., 1996)
embryonic stage 1 -- 2
organism | ubiquitous

Comment: reference states 1 hr AEL

(Yan et al., 1996)
embryonic stage 3 -- 6
organism | pair rule expression pattern

Comment: reference states 1-3 hr AEL

(Yan et al., 1996)
embryonic stage 6
pole cell
(Yan et al., 1996)
embryonic stage 15 -- 17
embryonic/larval foregut
(Yan et al., 1996)
embryonic/larval hindgut
(Yan et al., 1996)
embryonic stage 8 -- 17
gonad
(Yan et al., 1996)
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
mesectoderm anlage | subset
(Kearney et al., 2004)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal epidermis primordium

Comment: reported as dorsal epidermis anlage

(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
clypeo-labral primordium
(Fisher et al., 2012)
dorsal epidermis primordium
(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
hindgut proper primordium
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
tracheal primordium
(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic hindgut
(Fisher et al., 2012)
embryonic proventriculus
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
embryonic/larval muscle system
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
late third instar larval stage
lamina furrow
(Wang et al., 2011)
larval outer optic anlage
(Wang et al., 2011)
embryonic stage 1 -- 5
organism | ubiquitous
(Hou et al., 1996)
embryonic stage 5 -- 6
mesectoderm | subset
(Kearney et al., 2004)
embryonic stage 9 -- 12
midline primordium
(Kearney et al., 2004)
embryonic stage 9
ectoderm
(Liu et al., 2009)
mesoderm | striped
(Liu et al., 2009)
embryonic stage 10
ectoderm | striped
(Liu et al., 2009)
visceral muscle | striped
(Liu et al., 2009)
embryonic stage 11
somatic muscle
(Liu et al., 2009)
visceral muscle
(Liu et al., 2009)
adult stage
adult mushroom body
(Copf et al., 2011)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 15
embryonic/larval foregut
(Yan et al., 1996)
gonad | precursor
(Yan et al., 1996)
embryonic/larval hindgut
(Yan et al., 1996)
embryonic stage -- adult stage
(Hou et al., 1996, Yan et al., 1996)
Additional Descriptive Data

Expression pattern inferred from unspecified enhancer trap line.

(Kearney et al., 2004)

Stat92E transcripts are detected at all stages on northern blots. They are detected at high and uniformly distributed levels by in situ hybridization in early syncytial and cellularizing embryos. During germ band extension they are detected in a striped pattern within every segment.

(Hou et al., 1996)

Stat92E transcripts are detected at all stages of development by northern blot. Stat92E transcripts are detected in very early embryos in a uniform pattern by in situ hybridization. At the blastoderm stage, expression is seen in seven stripes in a broad central domain as well as in clusters of cells in anterior and posterior terminal segments. At germ band extension, 14 stripes are seen, restricted to mesodermal tissue. After germ band retraction, expression is observed mainly in the foregut, the hingut and in gonadal precursor cells.

(Yan et al., 1996)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
oogenesis stage S5 -- S7
nurse follicle cell
• nucleus
(Xi et al., 2003)
polar follicle cell
• nucleus
(Xi et al., 2003)
centripetally migrating follicle cell
• nucleus
(Xi et al., 2003)
border follicle cell
• nucleus
(Xi et al., 2003)
embryonic stage 9
organism | segment polarity expression pattern
(Chen et al., 2002)
second instar larval stage -- early third instar larval stage
larval outer optic anlage
(Wang et al., 2011)
first instar larval stage | male
hub cell
(Okegbe and DiNardo, 2011)
somatic cell of testis
(Okegbe and DiNardo, 2011)
male germline cell
(Okegbe and DiNardo, 2011)
adult stage | male & spermatogenesis
cyst progenitor cell
(Issigonis et al., 2009)
male germline stem cell
(Issigonis et al., 2009)
oogenesis stage S8
border follicle cell
(Monahan and Starz-Gaiano, 2013)
embryonic stage 13 -- 15
male germline cell
(Sheng et al., 2009)
embryonic stage 17
male germline cell | subset
(Sheng et al., 2009)
gonad | anterior
(Sheng et al., 2009)
first instar larval stage
male germline cell

Comment: hub-proximal

(Sheng et al., 2009)
adult stage
intestinal stem cell of posterior adult midgut epithelium
(Liu et al., 2010)
enteroblast of posterior adult midgut epithelium
(Liu et al., 2010)
calyx of adult mushroom body | restricted
(Copf et al., 2011)
Kenyon cell
(Copf et al., 2011)
adult brain
(Copf et al., 2011)
embryonic stage 15
gonad

Comment: male

(Wawersik et al., 2005)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
• membrane
(Aradska et al., 2015)
Additional Descriptive Data

The Stat92E expression in border follicle cell clusters overlaps Socs36E expression at stage S8.

(Monahan and Starz-Gaiano, 2013)

Stat92E is expressed widely in the adult brain. It localizes to Kenyon cell bodies and is also present in subdomains of the calyx. It is present in mushroom body cell bodies.

(Copf et al., 2011)

Stat92E protein is expressed the larval outer optic anlage from the second through late third larval instar. Expression is higher in in the lateral neuroepithelium, decreasing in medial cells.

(Wang et al., 2011)

Stat92E protein is expressed in ISCs and enteroblasts.

(Liu et al., 2010)

In testes, Stat92E protein is detected at higher levels in germline stem cells than in cyst progenitor cells.

(Issigonis et al., 2009)

Stat92E is found in male germline cells from embryonic stage 13. By mid stage 17, it is expressed in a subset of male germline cells localized to the anterior of the gonad. In early first instar larvae, phosphorylated Stat92E is restricted to hub-proximal germ cells.

(Sheng et al., 2009)

Stat92E is upregulated specifically in male, but not female, germ cells at the time of gonad formation. The activated (phosphorylated) form of Stat92E is also only detected in male germ cells. Stat92E expression in male germ cells in dependent on their association with the somatic gonad.

(Wawersik et al., 2005)

The Stat92E protein accumulates in the follicle cells of the polar regions and decreases toward the main body cells in the middle of the egg chamber in a pattern complementary to mirr expression.

(Xi et al., 2003)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
cytoplasmic side of apical plasma membrane
inferred from direct assay
(Sotillos et al., 2008)
cytosol
inferred from direct assay
(Sotillos et al., 2008, Agaisse et al., 2003)
nucleus
inferred from direct assay
(Sotillos et al., 2008, Agaisse et al., 2003, Kwon et al., 2000)
inferred from direct assay
(assigned by BHF-UCL )
(Li et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Stat92E in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 30 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 48 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Stat92E
Transgenic constructs containing regulatory region of Stat92E
Deletions and Duplications ( 4 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | embryonic stage, with Scer\GAL4Tub.PU, Stat92E85C9
lethal | embryonic stage, with Scer\GAL4Tub.PU, Stat92ER442A.UASp.Tag:HA
lethal | embryonic stage, with Scer\GAL4Tub.PU, Stat92ER442K.UASp.Tag:HA
lethal | embryonic stage, with Scer\GAL4Tub.PU, Stat92ER442P.UASp.Tag:HA
lethal | embryonic stage, with Scer\GAL4Tub.PU, Stat92EY711F.UASp.Tag:HA
lethal | embryonic stage (with Df(3R)H-B79)
lethal | embryonic stage | recessive
lethal | embryonic stage | recessive | rescuable maternal effect
lethal | first instar larval stage, with Scer\GAL4Tub.PU, Stat92E85C9
lethal | first instar larval stage, with Scer\GAL4Tub.PU, Stat92ER442A.UASp.Tag:HA
lethal | first instar larval stage, with Scer\GAL4Tub.PU, Stat92ER442K.UASp.Tag:HA
lethal | first instar larval stage, with Scer\GAL4Tub.PU, Stat92ER442P.UASp.Tag:HA
lethal | first instar larval stage, with Scer\GAL4Tub.PU, Stat92EY711F.UASp.Tag:HA
lethal | first instar larval stage (with Df(3R)H-B79)
lethal | first instar larval stage | recessive
lethal | heat sensitive, with Scer\GAL4dome-PG14
lethal | heat sensitive (with Stat92EF)
lethal | heat sensitive (with Stat92Ej6C8)
lethal | larval stage | recessive
lethal | recessive
lethal - all die before end of embryonic stage | germline clone | recessive | rescuable maternal effect
lethal - all die before end of embryonic stage | recessive
lethal - all die before end of pupal stage | heat sensitive (with Stat92E06346)
lethal - all die before end of pupal stage | heat sensitive (with Stat92EF)
lethal - all die before end of pupal stage | somatic clone
partially lethal - majority die, with Scer\GAL4pnr-MD237
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female sterile | heat sensitive (with Stat92E06346)
female sterile | heat sensitive (with Stat92EF)
female sterile | recessive
fertile
male sterile (with Stat92E06346)
male sterile (with Stat92EF)
male sterile | heat sensitive (with Stat92E06346)
male sterile | heat sensitive (with Stat92EF)
Other Phenotypes
Allele
decreased cell number | adult stage, with Scer\GAL4C587
decreased cell number | male | third instar larval stage, with Scer\GAL4C587
decreased fecundity | female | heat sensitive (with Stat92E06346)
decreased fecundity | female | heat sensitive (with Stat92EF)
decreased occurrence of cell division | adult stage | conditional, with Scer\GAL4how-24B
decreased occurrence of cell division | adult stage | conditional, with Scer\GAL4NP5130
decreased occurrence of cell division | embryonic stage | male
embryonic/larval segmentation phenotype | embryonic stage
hyperplasia | dominant | third instar larval stage
hyperplasia | larval stage, with Scer\GAL4dpp.blk1
immune response defective, with Scer\GAL4crq.Unk
immune response defective, with Scer\GAL4Hml.Δ
immune response defective | adult stage, with Scer\GAL4how-24B
immune response defective | adult stage, with Scer\GAL4NP5130
increased cell death | conditional | third instar larval stage
increased cell number | adult stage, with Scer\GAL4NP5130
increased cell number | adult stage | conditional, with Scer\GAL4Hml.Δ
increased occurrence of cell division | adult stage, with Scer\GAL4NP5130
melanotic mass phenotype | somatic clone, with Scer\GAL4Act5C.PI
memory defective | adult stage, with Scer\GAL4238Y
memory defective | adult stage | heat sensitive, with Scer\GAL4ey-OK107, Scer\GAL80ts.αTub84B
memory defective | adult stage | RU486 conditional, with Scer\GAL4Mef2.247.Switch
mitotic cell cycle defective | maternal effect
pair rule phenotype
planar polarity defective | recessive | somatic clone
size defective | adult stage, with Scer\GAL4sd.PU
size defective | somatic clone - Minute background | third instar larval stage
size defective | third instar larval stage, with Scer\GAL4en-e16E
small body | adult stage, with Scer\GAL4dome-PG14
small body | adult stage, with Scer\GAL4VGAT.PF
some die during embryonic stage | recessive
some die during embryonic stage | recessive | rescuable maternal effect
some die during embryonic stage | rescuable maternal effect
some die during pupal stage, with Scer\GAL4pnr-MD237
some die during pupal stage | heat sensitive (with Stat92E06346)
some die during pupal stage | heat sensitive (with Stat92EF)
some die during pupal stage | somatic clone
stress response defective | RU486 conditional, with Scer\GAL4Act5C.Switch.PR
visible
visible, with Scer\GAL4ey.PH
visible, with Scer\GAL4ey.PU
visible, with Scer\GAL4pnr-MD237
visible | adult stage, with Scer\GAL4en-e16E
visible | adult stage, with Scer\GAL4sd.PU
visible | dominant
visible | germline clone
visible | somatic clone
visible | somatic clone - Minute background
wild-type | germline clone
wild-type | somatic clone
Phenotype manifest in
Allele
abdominal 4 ventral denticle belt
abdominal 4 ventral denticle belt | germline clone | maternal effect
abdominal 5 ventral denticle belt
abdominal 5 ventral denticle belt | germline clone | maternal effect
abdominal 6 ventral denticle belt
abdominal 7 ventral denticle belt
abdominal 8 ventral denticle belt
abdominal segment 5
abdominal segment 8
adult cuticle (with Stat92E06346)
adult cuticle (with Stat92EF)
adult midgut epithelium, with Scer\GAL4NP5130
adult segment
antenna | somatic clone
axon
border follicle cell
border follicle cell, with Scer\GAL4slbo.2.6
border follicle cell (with Stat92E397), with Scer\GAL4- :
border follicle cell (with Stat92EEP3391), with Scer\GAL4- :
border follicle cell | heat sensitive (with Stat92E06346)
border follicle cell | heat sensitive (with Stat92EEP3391)
border follicle cell | heat sensitive (with Stat92EEP3391), with Scer\GAL4- :
border follicle cell | heat sensitive (with Stat92EF)
border follicle cell | heat sensitive (with Stat92EF), with Scer\GAL4- :
border follicle cell | somatic clone
central nervous system
commissure
cuticle & adult external head | somatic clone
cyst cell | heat sensitive (with Stat92EF)
cyst cell | heat sensitive (with Stat92Ej6C8)
cyst progenitor cell | heat sensitive (with Stat92E06346)
cyst progenitor cell | heat sensitive (with Stat92EF)
cyst progenitor cell | male | heat sensitive (with Stat92EF)
cyst progenitor cell | male | heat sensitive (with Stat92Ej6C8)
cyst progenitor cell | male | somatic clone
cyst progenitor cell | somatic clone
denticle belt | germline clone | rescuable maternal effect
dorsal appendage (with Stat92E06346)
dorsal appendage (with Stat92EF)
dorsal prothorax
ectoderm | extended germ band stage | germline clone
egg chamber
egg chamber (with Stat92E06346)
egg chamber (with Stat92EF)
egg chamber | somatic clone
embryonic/first instar larval cuticle
embryonic/larval anterior spiracle (with Stat92E06346)
embryonic/larval anterior spiracle (with Stat92EF)
embryonic/larval lymph gland | third instar larval stage
embryonic/larval posterior spiracle
embryonic/larval proventriculus
embryonic/larval somatic muscle
embryonic/larval somatic muscle | germline clone, with Scer\GAL4en.PU, Stat92E06346
embryonic/larval somatic muscle | germline clone, with Scer\GAL4en.PU, Stat92EUAS.cSa
embryonic/larval tracheal system | germline clone
embryonic abdominal segment
embryonic abdominal segment 2 | germline clone
embryonic abdominal segment 3 | germline clone
embryonic abdominal segment 4
embryonic abdominal segment 4 | germline clone
embryonic abdominal segment 4 | non-rescuable maternal effect
embryonic abdominal segment 5
embryonic abdominal segment 5 | germline clone
embryonic abdominal segment 5 | maternal effect
embryonic abdominal segment 5 | non-rescuable maternal effect
embryonic abdominal segment 6 | germline clone
embryonic abdominal segment 7 | germline clone
embryonic abdominal segment 8 | germline clone
embryonic abdominal segment | germline clone | maternal effect
embryonic head
embryonic hindgut | germline clone
embryonic mesothoracic segment | germline clone
embryonic metathoracic segment | germline clone
embryonic prothoracic segment | germline clone
embryonic segment
enteroblast of posterior adult midgut epithelium, with Scer\GAL4NP5130
enterocyte, with Scer\GAL4Tub.PU
enterocyte | somatic clone
epidermis
escort cell (with Stat92E06346)
escort cell (with Stat92EF)
escort stem cell (with Stat92E06346)
escort stem cell (with Stat92EF)
eye
eye, with Scer\GAL4ey.PH
eye, with Scer\GAL4ey.PU
eye | somatic clone
eye disc | somatic clone
eye disc | somatic clone - Minute background
filzkorper
filzkorper | germline clone | maternal effect
follicle cell | somatic clone
germarium, with Scer\GAL4C587
germarium (with Stat92E06346)
germarium (with Stat92EF)
germarium | cell non-autonomous | somatic clone
germline cell | embryonic stage | male
germline stem cell (with Stat92E06346)
germline stem cell (with Stat92EF)
gonad | embryonic stage | maternal effect
gonad | male | third instar larval stage, with Scer\GAL4C587
head | somatic clone
hemocyte | adult stage, with Scer\GAL4Hml.Δ
hindgut
hindgut & nucleus
imaginal disc
interfollicle cell (with Stat92E06346)
interfollicle cell (with Stat92EF)
interfollicle cell | anterior | cell autonomous
interfollicle cell | cell autonomous
intestinal stem cell of posterior adult midgut epithelium, with Scer\GAL4NP5130
larval optic anlage, with Scer\GAL4c768
leg (with Stat92E06346)
leg (with Stat92EF)
longitudinal connective
male germline stem cell, with Scer\GAL4nos.PU
male germline stem cell | cell autonomous | germline clone
male germline stem cell | germline clone
male germline stem cell | heat sensitive (with Stat92E06346)
male germline stem cell | heat sensitive (with Stat92EF)
male germline stem cell | heat sensitive (with Stat92Ej6C8)
male germline stem cell | third instar larval stage, with Scer\GAL4C587
melanotic mass | somatic clone, with Scer\GAL4Act5C.PI
mesothoracic segment
mesothoracic tergum, with Scer\GAL4pnr-MD237
mesothoracic tergum | adult stage | ectopic, with Scer\GAL4sd.PU
mesothoracic tergum primordium | ectopic | third instar larval stage, with Scer\GAL4sd.PU
mesothoracic ventral denticle belt
midgut, with Scer\GAL4how-24B, Scer\GAL80ts.αTub84B
midgut, with Scer\GAL4NP5130, Scer\GAL80ts.αTub84B
morphogenetic furrow | somatic clone
mouth hooks | germline clone
nurse follicle cell | somatic clone
ommatidium | somatic clone
oocyte
oocyte (with Stat92E06346)
oocyte (with Stat92EF)
ovarian basement membrane (with Stat92E06346)
ovarian basement membrane (with Stat92EF)
ovarian basement membrane | cell non-autonomous | somatic clone
ovarian sheath cell (with Stat92E06346)
ovarian sheath cell (with Stat92EF)
ovarian sheath cell | cell non-autonomous | somatic clone
ovariole
peripheral nervous system
plasmatocyte | third instar larval stage
polar follicle cell
pole cell | maternal effect
posterior spiracle primordium | germline clone
presumptive embryonic/larval tracheal system
segment
spectrosome | cell non-autonomous | somatic clone
spermathecum | supernumerary (with Stat92E06346)
spermathecum | supernumerary (with Stat92EF)
spermatocyte | heat sensitive (with Stat92E06346)
spermatocyte | heat sensitive (with Stat92EF)
spermatocyte | heat sensitive (with Stat92Ej6C8)
spermatogonium | heat sensitive (with Stat92E06346)
spermatogonium | heat sensitive (with Stat92EF)
spermatogonium | heat sensitive (with Stat92Ej6C8)
telson
trachea
tracheal branch primordium | germline clone
tracheal pit
tracheal system
trichogen cell, with Scer\GAL4pnr-MD237
wing, with Scer\GAL4sd.PU
wing, with Scer\GAL4VGAT.PF
wing blade posterior compartment
wing disc, with Scer\GAL4dpp.blk1
wing disc | conditional | third instar larval stage
wing disc | third instar larval stage
wing disc posterior compartment | somatic clone - Minute background | third instar larval stage
wing disc posterior compartment | third instar larval stage, with Scer\GAL4en-e16E
wing hinge primordium | third instar larval stage, with Scer\GAL4NP3253
wing hinge primordium | third instar larval stage, with Scer\GAL4zfh2-MS209
wing pouch | ectopic | third instar larval stage, with Scer\GAL4ptc.PU
wing vein
wing vein | ectopic
wing vein | ectopic, with Scer\GAL4en-e16E
wing vein | ectopic (with Stat92E06346)
wing vein | ectopic (with Stat92EF)
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\STAT5B
12 of 15
Yes
Yes
 
Hsap\STAT5A
11 of 15
No
Yes
Hsap\STAT6
8 of 15
No
Yes
Hsap\STAT1
3 of 15
No
Yes
 
Hsap\STAT2
3 of 15
No
Yes
Hsap\STAT3
3 of 15
No
Yes
 
Hsap\STAT4
3 of 15
No
Yes
 
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Stat5b
12 of 15
Yes
Yes
Mmus\Stat5a
11 of 15
No
Yes
Mmus\Stat6
7 of 15
No
Yes
Mmus\Stat1
3 of 15
No
Yes
Mmus\Stat3
3 of 15
No
Yes
Mmus\Stat4
3 of 15
No
Yes
Mmus\Stat2
2 of 15
No
Yes
Rattus norvegicus (Norway rat) (7)
Rnor\Stat5b
10 of 13
Yes
Yes
Rnor\Stat6
8 of 13
No
Yes
Rnor\Stat5a
6 of 13
No
Yes
Rnor\Stat2
4 of 13
No
Yes
Rnor\Stat3
3 of 13
No
Yes
Rnor\Stat1
2 of 13
No
Yes
Rnor\Stat4
2 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (6)
Xtro\stat5b
5 of 12
Yes
Yes
Xtro\stat6
3 of 12
No
Yes
Xtro\stat1
1 of 12
No
Yes
Xtro\stat2
1 of 12
No
Yes
Xtro\stat3.1
1 of 12
No
Yes
Xtro\stat4
1 of 12
No
Yes
Danio rerio (Zebrafish) (8)
Drer\stat5a
11 of 15
Yes
Yes
Drer\stat6
8 of 15
No
Yes
Drer\stat5b
7 of 15
No
Yes
Drer\stat1a
3 of 15
No
Yes
Drer\stat1b
3 of 15
No
Yes
Drer\stat2
3 of 15
No
Yes
Drer\stat3
3 of 15
No
Yes
Drer\stat4
3 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\sta-1
11 of 15
Yes
Yes
Cele\sta-2
2 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (1)
Atha\ELP6
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\BLI1
1 of 15
Yes
Yes
Scer\YPL245W
1 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091902YD )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\Stat92E
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00011311
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00011994
Drosophila simulans
Dsim\GD20060
Drosophila sechellia
Dsec\GM23187
Drosophila erecta
Dere\GG15412
Drosophila yakuba
Dyak\GE25067
Drosophila ananassae
Dana\GF23202
Drosophila pseudoobscura pseudoobscura
Dpse\GA26501
Drosophila persimilis
Dper\GL24086
Drosophila willistoni
Dwil\GK22722
Drosophila virilis
Dvir\GJ24191
Drosophila mojavensis
Dmoj\GI10538
Drosophila grimshawi
Dgri\GH14167
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501UV )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17007499
Musca domestica
House fly
Mdoa\17012345
Glossina morsitans
Tsetse fly
Gmor\GMOY008510
Glossina morsitans
Tsetse fly
Gmor\GMOY003394
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_03653
Mayetiola destructor
Hessian fly
Mdes\Mdes006230
Aedes aegypti
Yellow fever mosquito
Aaeg\STAT1
Anopheles darlingi
American malaria mosquito
Adar\ADAC010176
Anopheles gambiae
Malaria mosquito
Agam\STAT2
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ016471
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ016469
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01MY )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA001739
Danaus plexippus
Monarch butterfly
Dple\DPOGS212956-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL007184
Apis florea
Little honeybee
Aflo\2687567828
Apis mellifera
Western honey bee
Amel\STAT92E-like
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP14982
Bombus terrestris
Buff-tailed bumblebee
Bter\15205579
Linepithema humile
Argentine ant
Lhum\LH26246
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG007751
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_08642
Tribolium castaneum
Red flour beetle
Tcas\Stat
Pediculus humanus
Human body louse
Phum\PHUM335200
Rhodnius prolixus
Kissing bug
Rpro\RPRC006502
Cimex lectularius
Bed bug
Clec\CLEC002611
Cimex lectularius
Bed bug
Clec\CLEC002610
Cimex lectularius
Bed bug
Clec\CLEC002609
Cimex lectularius
Bed bug
Clec\CLEC002612
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI002351
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005642
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI44613
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_16675
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01KX )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR014120
Ixodes scapularis
Black-legged tick
Isca\ISCW005692
Stegodyphus mimosarum
African social velvet spider
Smim\KFM58134.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur36g00600
Tetranychus urticae
Two-spotted spider mite
Turt\tetur17g02010
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_97641
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G03O3 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Stat
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000004044
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000010308
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000025956
Gallus gallus
Domestic chicken
Ggal\STAT4
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000007651
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000003267
Gallus gallus
Domestic chicken
Ggal\STAT5B
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Evidence
    References
    Stat92EΔNΔC.UASp.Tag:HA
    model of  cancer
    CEA with scribKK101128, RhoGEF2HMS01118
    (Tamori et al., 2016)
    Potential Models Based on Orthology ( 2 )
    Modifiers Based on Experimental Evidence ( 11 )
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    STAT5B; signal transducer and activator of transcription 5B
    12 of 15
    604260
       
      STAT5A; signal transducer and activator of transcription 5A
      11 of 15
      601511
          STAT6; signal transducer and activator of transcription 6
          8 of 15
          601512
              STAT1; signal transducer and activator of transcription 1
              3 of 15
              600555
               
              STAT2; signal transducer and activator of transcription 2
              3 of 15
              600556
                STAT3; signal transducer and activator of transcription 3
                3 of 15
                102582
                 
                STAT4; signal transducer and activator of transcription 4
                3 of 15
                600558
                   
                  Functional Complementation Data
                  Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                  Interactions
                  Summary of Physical Interactions
                  esyN Network Diagram
                  Show neighbor-neighbor interactions:
                  Select Layout:
                  Legend:
                  Protein
                  RNA
                  Selected Interactor(s)
                  Interactions Browser
                  View in Interactions Browser
                  Please see the Physical Interaction reports below for full details
                  RNA-RNA
                  Physical Interaction
                  Assay
                  References
                  Stat92E - mir-279
                  luminiscence technology, necessary binding region, immunohistochemistry
                  (Yoon et al., 2011)
                  protein-protein
                  Physical Interaction
                  Assay
                  References
                  Stat92E - Ada2b
                  anti tag coimmunoprecipitation, peptide massfingerprinting
                  (Weake et al., 2011)
                  Stat92E - Cdk2
                  anti bait coimmunoprecipitation, anti tag western blot, western blot
                  (Chen et al., 2003)
                  Stat92E - Cdk4
                  anti bait coimmunoprecipitation, anti tag western blot
                  (Chen et al., 2003)
                  Stat92E - Cnot4
                  anti bait coimmunoprecipitation, anti tag western blot
                  (Grönholm et al., 2012)
                  Stat92E - CycD
                  anti bait coimmunoprecipitation, anti tag western blot
                  (Chen et al., 2003)
                  Stat92E - D
                  two hybrid array
                  (Shokri et al., 2019)
                  Stat92E - Dsp1
                  anti bait coimmunoprecipitation, western blot
                  (Kim et al., 2007)
                  Stat92E - HDAC1
                  anti bait coimmunoprecipitation, western blot
                  (Kim et al., 2007)
                  Stat92E - His1
                  pull down, anti tag western blot
                  (Xu et al., 2014)
                  Stat92E - Jra
                  anti bait coimmunoprecipitation, western blot
                  (Kim et al., 2007)
                  Stat92E - Socs36E
                  anti tag coimmunoprecipitation, anti tag western blot
                  (Hoi et al., 2016)
                  Stat92E - Socs44A
                  anti tag coimmunoprecipitation, anti tag western blot
                  (Hoi et al., 2016)
                  Stat92E - Su(var)205
                  anti tag coimmunoprecipitation, anti tag western blot, pull down, western blot, anti bait coimmunoprecipitation
                  (Xu et al., 2014, Shi et al., 2008)
                  Stat92E - Taf1
                  anti bait coimmunoprecipitation, western blot
                  (Panov et al., 2012)
                  Stat92E - baz
                  anti tag coimmunoprecipitation, western blot, pull down, autoradiography
                  (Sotillos et al., 2013, Sotillos et al., 2008)
                  Stat92E - ci
                  anti tag coimmunoprecipitation, anti tag western blot
                  (Liu et al., 2015)
                  Stat92E - dome
                  anti bait coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation, western blot
                  (Fisher et al., 2016, Chen et al., 2002)
                  Stat92E - e(y)3
                  anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, anti tag western blot, molecular sieving
                  (Panov et al., 2012)
                  Stat92E - et
                  anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation, anti tag western blot
                  (Fisher et al., 2016)
                  Stat92E - hop
                  anti tag coimmunoprecipitation, anti tag western blot
                  (Hoi et al., 2016)
                  Stat92E - mor
                  anti bait coimmunoprecipitation, western blot
                  (Panov et al., 2012)
                  Summary of Genetic Interactions
                  esyN Network Diagram
                  esyN Network Key:
                  Suppression
                  Enhancement
                  View in Interactions Browser
                  Please look at the allele data for full details of the genetic interactions
                  Starting gene(s)
                  Interaction type
                  Interacting gene(s)
                  Reference
                  Stat92E
                  suppressible
                  BHD
                  (Singh et al., 2006)
                  Csk|Stat92E
                  suppressible
                  Btk29A
                  (Read et al., 2004)
                  Stat92E
                  enhanceable
                  Csk
                  (Read et al., 2004)
                  Stat92E
                  suppressible
                  Diap1
                  (Betz et al., 2008)
                  Stat92E
                  enhanceable
                  dome
                  (Brown et al., 2001)
                  Stat92E
                  suppressible
                  dpp
                  (Singh et al., 2006)
                  Stat92E
                  enhanceable
                  hop
                  (Zeidler et al., 1999)
                  Stat92E
                  suppressible
                  hop
                  (Luo et al., 1997, Yan et al., 1996)
                  Stat92E
                  enhanceable
                  Ras85D
                  (Li et al., 2003)
                  Stat92E
                  enhanceable
                  Socs36E
                  (Singh et al., 2010)
                  Stat92E
                  suppressible
                  Sox21a
                  (Zhai et al., 2015)
                  Stat92E|Src42A
                  enhanceable
                  Src64B
                  (Sotillos et al., 2013)
                  Stat92E
                  suppressible
                  wg
                  (Ekas et al., 2006)
                  Starting gene(s)
                  Interaction type
                  Interacting gene(s)
                  Reference
                  apt
                  suppressible
                  Stat92E
                  (Starz-Gaiano et al., 2008)
                  bip1
                  suppressible
                  Stat92E
                  (Mondal et al., 2014)
                  ci
                  suppressible
                  Stat92E
                  (Liu et al., 2015)
                  cic|tor|trk
                  suppressible
                  Stat92E
                  (de las Heras and Casanova, 2006)
                  Csk
                  enhanceable
                  Stat92E
                  (Read et al., 2004)
                  csw
                  enhanceable
                  Stat92E
                  (Oishi et al., 2006)
                  dome
                  enhanceable
                  Stat92E
                  (Ghiglione et al., 2002, Brown et al., 2001)
                  Egfr::tor
                  suppressible
                  Stat92E
                  (Buchon et al., 2010)
                  Egfr
                  suppressible
                  Stat92E
                  (Li and Li, 2003)
                  Egfr|Socs36E
                  suppressible
                  Stat92E
                  (Herranz et al., 2012)
                  gcm
                  suppressible
                  Stat92E
                  (Jacques et al., 2009)
                  Hipk
                  enhanceable
                  Stat92E
                  (Blaquiere et al., 2018)
                  hop
                  suppressible
                  Stat92E
                  (Bausek and Zeidler, 2014, Bina et al., 2010, Muller et al., 2005, Remillieux-Leschelle et al., 2002, Luo et al., 1997, Hou et al., 1996, Yan et al., 1996, Yan et al., 1996)
                  l(2)gl
                  suppressible
                  Stat92E
                  (Tamori et al., 2016)
                  l(2)gl
                  enhanceable
                  Stat92E
                  (Tamori et al., 2016)
                  L
                  suppressible
                  Stat92E
                  (Wang and Huang, 2009)
                  lid
                  suppressible
                  Stat92E
                  (Tarayrah et al., 2015)
                  lid
                  enhanceable
                  Stat92E
                  (Tarayrah et al., 2015)
                  Ptp61F
                  suppressible
                  Stat92E
                  (Buszard et al., 2013)
                  Rabex-5
                  suppressible
                  Stat92E
                  (Thomas and Strutt, 2014)
                  Rac1
                  suppressible
                  Stat92E
                  (Silver, 2005)
                  Ras85D
                  enhanceable
                  Stat92E
                  (Li et al., 2003)
                  Ras85D|scrib
                  suppressible
                  Stat92E
                  (Wu et al., 2010)
                  Rnf146
                  suppressible
                  Stat92E
                  (Gultekin and Steller, 2019)
                  scrib
                  enhanceable
                  Stat92E
                  (Tamori et al., 2016)
                  slbo
                  suppressible
                  Stat92E
                  (Beccari et al., 2002)
                  smo
                  suppressible
                  Stat92E
                  (Liu et al., 2015)
                  Snr1
                  suppressible
                  Stat92E
                  (Xie et al., 2017)
                  Socs36E
                  enhanceable
                  Stat92E
                  (Callus and Mathey-Prevot, 2002)
                  Src42A
                  suppressible
                  Stat92E
                  (Cordero et al., 2014)
                  Su(var)2-10
                  suppressible
                  Stat92E
                  (Betz et al., 2001)
                  Su(var)2-10
                  enhanceable
                  Stat92E
                  (Betz et al., 2001)
                  Sulf1
                  suppressible
                  Stat92E
                  (Takemura and Nakato, 2017)
                  Tl
                  suppressible
                  Stat92E
                  (Remillieux-Leschelle et al., 2002)
                  tor
                  suppressible
                  Stat92E
                  (Li and Li, 2003, Li et al., 2002)
                  TSG101
                  suppressible
                  Stat92E
                  (Moberg et al., 2005)
                  tsl
                  suppressible
                  Stat92E
                  (de las Heras and Casanova, 2006)
                  Uba1
                  suppressible
                  Stat92E
                  (Lee et al., 2008)
                  upd1
                  suppressible
                  Stat92E
                  (Mukherjee et al., 2006, Muller et al., 2005, Read et al., 2004, Tsai and Sun, 2004, Bach et al., 2003)
                  upd3
                  enhanceable
                  Stat92E
                  (Wang et al., 2014)
                  Uvrag
                  suppressible
                  Stat92E
                  (Nagy et al., 2016)
                  Vps25
                  suppressible
                  Stat92E
                  (Vaccari and Bilder, 2005)
                  External Data
                  Subunit Structure (UniProtKB)
                  Forms a homodimer or a heterodimer with a related family member.
                  (UniProt, Q24151 )
                  Linkouts
                  BioGRID - A database of protein and genetic interactions.
                  DroID - A comprehensive database of gene and protein interactions.
                  InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                  MIST (genetic) - An integrated Molecular Interaction Database
                  MIST (protein-protein) - An integrated Molecular Interaction Database
                  Pathways
                  Signaling Pathways (FlyBase)
                  JAK-STAT Signaling Pathway Core Components -
                  The JAK-STAT signaling pathway is initiated by the binding of an extracellular ligand to a cell surface receptor leading to receptor dimerization and the intracellular activation of a Janus kinase (JAK) family member. JAK phosphorylates cytoplasmic STAT family members which dimerize, translocate into the nucleus and regulate target gene expression. In Drosophila, the core pathway is limited to three ligands (the Unpaired family of cytokines), a single receptor (dome), JAK kinase (hop) and STAT (Stat92E). (Adapted from FBrf0225259).
                  Metabolic Pathways
                  External Data
                  Genomic Location and Detailed Mapping Data
                  Chromosome (arm)
                  3R
                  Recombination map

                  3-69

                  Cytogenetic map
                  92F1-92F1
                  Sequence location
                  3R:20,535,323..20,552,311 [-]
                  FlyBase Computed Cytological Location
                  Cytogenetic map
                  Evidence for location
                  92F1-92F1
                  Limits computationally determined from genome sequence between P{PZ}l(3)1058510585 and P{EP}SyndEP409
                  Experimentally Determined Cytological Location
                  Cytogenetic map
                  Notes
                  References
                  92E2-92E2
                  (Yan, 1996.1.19)
                  92E2-92E4
                  (determined by in situ hybridisation)
                  (Spradling et al., 1999, Hou et al., 1996, Perrimon et al., 1996)
                  92E-92E
                  (determined by in situ hybridisation)
                  (Yan et al., 1996)
                  92E2-92E2
                  (determined by in situ hybridisation)
                  (Yan et al., 1996)
                  92E1-92E2
                  92E2--4
                  (BDGP Project Members, 1994-1999)
                  Experimentally Determined Recombination Data
                  Location

                  3-69

                  (FlyBase, 2016)

                  3-72.7

                  (Comeron et al., 2012)

                  3-

                  (Yan, 1996.1.19)

                  3-68.9

                  (Yan et al., 1996)
                  Left of (cM)
                  (Yan et al., 1996)
                  Right of (cM)
                  (Yan et al., 1996)
                  Notes
                  Stocks and Reagents
                  Stocks (25)
                  Genomic Clones (24)
                  cDNA Clones (205)
                   

                  Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                  cDNA clones, fully sequences
                  BDGP DGC clones
                  Other clones
                  Drosophila Genomics Resource Center cDNA clones

                  For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                  cDNA Clones, End Sequenced (ESTs)
                  BDGP DGC clones
                  Other clones
                  RNAi and Array Information
                  Linkouts
                  DRSC - Results frm RNAi screens
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  Antibody Information
                  Laboratory Generated Antibodies
                   

                  polyclonal

                  (Willoughby et al., 2017, Liu et al., 2015, Panov et al., 2012, Flaherty et al., 2010, Shi et al., 2008, Chen et al., 2002)
                  Commercially Available Antibodies
                   
                  Other Information
                  Relationship to Other Genes
                  Source for database identify of

                  Source for identity of: Stat92E CG4257

                  (Gong, 1999.11)
                  Source for database merge of
                  Additional comments
                  Other Comments

                  DNA-protein interactions: genome-wide binding profile assayed for Stat92E protein in 0-12 hr embryos; see mE1_TFBS_Stat92E collection report.

                  (Negre et al., 2011)

                  dsRNA made from templates generated with primers directed against this gene.

                  (Bartscherer et al., 2006)

                  dsRNA made from templates generated with primers directed against this gene used in a cell-based RNAi assay to identify components or modifiers of the JAK/STAT pathway.

                  (Mukherjee et al., 2006)

                  Treatment of S2-derived S2-NP cells with dsRNA made from templates generated with primers directed against Stat92E results in a 12-24-fold decrease in JAK/STAT activity.

                  (Baeg et al., 2005)

                  dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                  (Kiger et al., 2003)

                  Stat92E is involved in proper differentiation and morphogenesis of multiple tissues.

                  (Li et al., 2003)

                  Stat92E acts downstream of the Dl/N pathway to induce the differentiation of the interfollicle (or stalk) cells. Stalks cause the polarization of adjacent anterior egg chambers by inducing shape change and preferential adhesion that positions the oocyte at the posterior.

                  (Torres et al., 2003)

                  Stat92E function is necessary for the proper differentiation of the polar follicle cells and the interfollicle cells. The failure of these cell to differentiate correctly leads to fused egg chambers and results in female sterility. Stat92E is part of an intracellular Jak-Stat signalling pathway and is activated by the hop Jak kinase. Partial loss of hop gene product activity gives a phenotype similar to that of Stat92E mutants, supporting the idea that the Jak-Stat pathway is involved in regulation of oogenesis.

                  (Baksa et al., 2002)

                  Stat92E is required autonomously in the germ cells for germline stem cell maintenance.

                  (Kiger et al., 2001)

                  Stat92E is required for border cell migration.

                  (Silver and Montell, 2001)

                  Stat92E is required in the male germline for maintenance of germ line stem cell renewal.

                  (Tulina and Matunis, 2001)

                  Dominant hop mutations cause hop to be a hyperactive kinase that can cause hyperactivation of the hop Stat92E pathway.

                  (Luo et al., 1997)

                  Stat92E acts downstream of the hop kinase and encodes a protein similar to the mammalian Stat proteins. hop may activate Stat92E to regulate transcription of target genes such as eve. Stat92E is epistatic to hop.

                  (Hou et al., 1996)

                  The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(whs)} P{hsFLP} chromosomes) has been used to identify the specific maternal effect phenotype for the zygotic lethal mutation.

                  (Perrimon et al., 1996)

                  Stat92E has been identified both by molecular and genetic strategies. A mutation in Stat92E has been identified by suppression of a hop mutant phenotype. Two binding sites for Stat92E protein have been identified in the eve stripe 3 enhancer region.

                  (Yan et al., 1996)

                  An allele of Stat92E was identified in a screen for second site suppressors of hopTum. Stat92E is involved in wing vein and trachea development, and segmentation in embryos and adults.

                  (Yan et al., 1996)

                  A unique binding activity that resembles the Stat-like activity of the mammalian system is identified in Drosophila and is encoded by pp100 and pp150 polypeptides. Vanadate/hydrogen peroxide treatment of Schneider cells induces a specific GRR binding complex whose formation is dependent upon Tyr phosphorylation.

                  (Sweitzer et al., 1995)
                  Origin and Etymology
                  Discoverer
                  Etymology

                  "marelle" is French for "hopscotch".

                  (Hou et al., 1996)
                  Identification
                  External Crossreferences and Linkouts ( 134 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                  UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                  Other crossreferences
                  BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                  Flygut - An atlas of the Drosophila adult midgut
                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  InterPro - A database of protein families, domains and functional sites
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  modMine - A data warehouse for the modENCODE project
                  SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                  Linkouts
                  BioGRID - A database of protein and genetic interactions.
                  DPiM - Drosophila Protein interaction map
                  DroID - A comprehensive database of gene and protein interactions.
                  DRSC - Results frm RNAi screens
                  FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                  FlyMine - An integrated database for Drosophila genomics
                  Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                  InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                  KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                  MIST (genetic) - An integrated Molecular Interaction Database
                  MIST (protein-protein) - An integrated Molecular Interaction Database
                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                  Synonyms and Secondary IDs (45)
                  Reported As
                  Symbol Synonym
                  CG4257
                  (Hosono et al., 2015, Schertel et al., 2013, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Fujikawa et al., 2009, Keleman et al., 2009.8.5, Ni et al., 2008, Talamillo et al., 2008, Molnar et al., 2006)
                  D-STAT
                  (Kim et al., 2013, Barolo and Posakony, 2004, Barolo and Posakony, 2002, Baksa et al., 2000, Kwon et al., 2000, Heinrich et al., 1998, Briscoe et al., 1996)
                  D-Stat
                  (Hartmann et al., 2013, Park et al., 2003, Kulkarni and Arnosti, 2001, Small et al., 1996, Small et al., 1996)
                  D-stat
                  (Zeidler and Bausek, 2013, Remillieux-Leschelle et al., 2002, Sorrentino et al., 1999, Luo et al., 1997, Yan, 1996.1.19)
                  D-stat/stat92E
                  (Gilbert et al., 2002)
                  DRODSRC
                  (Colson and Goldstein, 1999)
                  DSRC
                  (Colson and Goldstein, 1999)
                  DSTAT
                  (Martinez et al., 2014, Savant-Bhonsale et al., 1999)
                  DmSTAT
                  (Lin et al., 2004)
                  Dstat
                  (Zhang and Moret, 2010, Schroeder et al., 2004, Ghiglione et al., 2002, Govind et al., 1999, Dearolf, 1998)
                  Dstat 92E
                  (Morey and Harrison, 1998)
                  Dstat92E
                  (Morey and Harrison, 1999, Devanaboyina and Harrison, 1998)
                  SD-stat
                  (Luo et al., 1999)
                  STAT
                  (Lin et al., 2019, Loyola et al., 2019, Panettieri et al., 2019, Zhang et al., 2019, Kang et al., 2018, Prange et al., 2018, Ferguson and Martinez-Agosto, 2017, Mussabekova et al., 2017, Zhao and Karpac, 2017, Deshpande et al., 2016, Kotov et al., 2016, Kwon et al., 2016, Niwa and Niwa, 2016, Saadin and Starz-Gaiano, 2016, Verghese and Su, 2016, Yadav et al., 2016, Dorn and Dorn, 2015, Qian et al., 2015, Ren et al., 2015, Sun et al., 2015, Thomas et al., 2015, Zhou et al., 2015, Mannervik, 2014, Mondal et al., 2014, Tipping and Perrimon, 2014, Zhou et al., 2014, Ferrandon, 2013, Gonzalez, 2013, Huang et al., 2013, Kingsolver et al., 2013, Monahan and Starz-Gaiano, 2013, Woodfield et al., 2013, Zhang et al., 2013, Zhou et al., 2013, Hayashi et al., 2012, Jemc et al., 2012, Osman et al., 2012, Vanha-Aho et al., 2012, Gonsalves et al., 2011, Tsurumi et al., 2011, Yan et al., 2011, Yoon et al., 2011, Zheng et al., 2011, Buchon et al., 2010, Colodner and Feany, 2010, Buchon et al., 2009, Gutierrez-Aviño et al., 2009, Starz-Gaiano et al., 2009, Wang and Huang, 2009, Ayala and Bach, 2008, Baudot et al., 2008, Cinnamon et al., 2008, Copf and Preat, 2008, Han and Harrison, 2008, Issigonis et al., 2008, McConnell et al., 2008, McDonald et al., 2008, Pastor-Pareja et al., 2008, Starz-Gaiano et al., 2008, Wawersik et al., 2008, Yasugi et al., 2008, Devergne et al., 2007, Eleftherianos et al., 2007, Kimble and Page, 2007, Kronhamn et al., 2007, Krzemien et al., 2007, Rivas et al., 2007, Shi et al., 2007, Sotillos and Castelli-Gair, 2007, Tsai et al., 2007, Bartscherer et al., 2006, Borghese et al., 2006, Castelli-Gair Hombria, 2006, DEVERGNE and NOSELLI, 2006, Montell, 2006, Sheng et al., 2006, Brawley et al., 2005, Brown et al., 2005, Dostert et al., 2005, Ip, 2005, Sheng et al., 2005, Beachy et al., 2004, Ohlstein et al., 2004, Terry et al., 2004, Wawersik et al., 2004, Agaisse et al., 2003, Feix et al., 2003, Gilbert et al., 2003, Hultmark and Ekengren, 2003, Mukherjee and Zeidler, 2003, Seyedoleslami Esfahani et al., 2003, Solnica-Krezel and Eaton, 2003, Castelli-Gair Hombria and Brown, 2002, Kisseleva et al., 2002, Lavine and Strand, 2002, Rawlings and Harrison, 2002, Rorth, 2002, Silver and Montell, 2002, Matunis and Tulina, 2001, Mushegian and Medzhitov, 2001, Wasserman and DiNardo, 2001, Khush and Lemaitre, 2000, Meister et al., 2000, Blair, 1999, Perrimon and Stern, 1999, Zeidler et al., 1999, Mathey-Prevot et al., 1998, Zeidler and Perrimon, 1998)
                  STAT 92E
                  (Xi and Harrison, 2000)
                  STAT92
                  (Roeder et al., 2009)
                  STAT92E
                  (Bernardoni et al., 2019, Camara et al., 2019, Ho et al., 2019, Kim et al., 2019, Sreejith et al., 2019, Wang et al., 2019, Yang et al., 2019, Ahmed-de-Prado and Baonza, 2018, Fisher et al., 2018, Mehrotra and Deshpande, 2018, Yu et al., 2018, Khanna et al., 2017, Lu et al., 2017, Purice et al., 2017, Takemura and Nakato, 2017, Willoughby et al., 2017, Winfree et al., 2017, Xie et al., 2017, Bayona-Feliu et al., 2016, Musashe et al., 2016, Tamori et al., 2016, Boija and Mannervik, 2015, Freeman, 2015, Glassford et al., 2015, Grifoni et al., 2015, Housden et al., 2015, Li et al., 2015, Ren et al., 2015, Tsai et al., 2015, Kux and Pitsouli, 2014, Li et al., 2014, Wang et al., 2014, Xu et al., 2014, You et al., 2014, Bausek, 2013, Buszard et al., 2013, Morin-Poulard et al., 2013, Oldefest et al., 2013, Silver-Morse and Li, 2013, Stec et al., 2013, Wang et al., 2013, Zeidler and Bausek, 2013, Zoranovic et al., 2013, Amoyel and Bach, 2012, Bier and Guichard, 2012, Igboin et al., 2012, Jemc et al., 2012, Luo and Sehgal, 2012, Panov et al., 2012, Crozatier and Vincent, 2011, Kim et al., 2011, Li et al., 2011, Rodriguez, 2011, Stec and Zeidler, 2011, Tsurumi et al., 2011, Grönholm et al., 2010, Sotillos et al., 2010, Benítez et al., 2009, Buchon et al., 2009, Gutierrez-Aviño et al., 2009, Li et al., 2009, Sheng et al., 2009, Kim et al., 2008, Nallamothu et al., 2008, Shi et al., 2008, Assa-Kunik et al., 2007, Betz et al., 2007, Sheng et al., 2007, Silver et al., 2007, Arbouzova and Zeidler, 2006, Arbouzova et al., 2006, Wang et al., 2006, Baeg et al., 2005, Gesellchen et al., 2005, Kai et al., 2005, Reynolds-Kenneally and Mlodzik, 2005, Agaisse and Perrimon, 2004, Karsten et al., 2004, Mukherjee et al., 2004, Ren et al., 2004, Starz-Gaiano and Montell, 2004, Tsai and Sun, 2004, Arbouzova et al., 2003, Chen et al., 2003, Lemaitre, 2000.12.20)
                  STAT92e
                  (Sherri et al., 2018, Sinha et al., 2013)
                  Stat
                  (Petrovsky and Großhans, 2018, Pinal et al., 2018, Baker, 2017, Sousa-Victor et al., 2017, Atkins et al., 2016, Calleja et al., 2016, Tarayrah et al., 2015, Wang et al., 2015, Merkling and van Rij, 2013, Ren et al., 2013, Okegbe and DiNardo, 2011, Takashima et al., 2011, Makki et al., 2010, Pek et al., 2009, Shen et al., 2009, Lee et al., 2008, Wrobel et al., 2008, Tolwinski, 2007, Wallenfang and DiNardo, 2004, Bruckner et al., 2003, Lopez-Schier, 2003, Lin, 2002, Peifer and McEwen, 2002, Kockel et al., 2001, Dearolf et al., 1997, Luo and Dearolf, 1997, Yan et al., 1996)
                  Stat1α-like
                  (Sweitzer et al., 1995)
                  Stat92
                  (Jaszczak and Halme, 2016, Webber et al., 2013, Ni et al., 2008)
                  Stat92E
                  (Ahlers et al., 2019, Asri et al., 2019, Bailetti et al., 2019, Banerjee et al., 2019, Chai et al., 2019, Coelho and Moreno, 2019, Engel et al., 2019, Gultekin and Steller, 2019, Herrera and Bach, 2019, Houtz et al., 2019, Kim et al., 2019, La Marca et al., 2019, Nelson et al., 2019, Powers and Srivastava, 2019, Reedy et al., 2019, Shokri et al., 2019, Singh et al., 2019, Sinha et al., 2019, Snigdha et al., 2019, Wang et al., 2019, Wittes and Schüpbach, 2019, Xu et al., 2019, Yang et al., 2019, Ahmed-de-Prado et al., 2018, Gene Disruption Project members, 2018-, Green et al., 2018, Hao et al., 2018, Yu and Pan, 2018, Barr et al., 2017, Feng et al., 2017, Lee et al., 2017, Pascual et al., 2017, Péan et al., 2017, Torres et al., 2017, Transgenic RNAi Project members, 2017-, Tsurumi et al., 2017, Atkins et al., 2016, Clandinin and Owens, 2016-, Harris et al., 2016, Hoi et al., 2016, Kwon et al., 2016, Mbodj et al., 2016, Monahan and Starz-Gaiano, 2016, Moulton and Letsou, 2016, Nagy et al., 2016, Padash Barmchi et al., 2016, Purice et al., 2016, Saadin and Starz-Gaiano, 2016, Saha et al., 2016, Shen et al., 2016, Verghese and Su, 2016, Aradska et al., 2015, Kohlmaier et al., 2015, Moreno et al., 2015, Moskalev et al., 2015, Schertel et al., 2015, Seeds et al., 2015, Sopko et al., 2015, Terhzaz et al., 2015, Van Bortle et al., 2015, Woodcock et al., 2015, Xia et al., 2015, Zhai et al., 2015, Boyle et al., 2014, Chabu and Xu, 2014, Chen et al., 2014, Doherty et al., 2014, Issman-Zecharya and Schuldiner, 2014, Jiang and Singh, 2014, Lee et al., 2014, Salazar-Jaramillo et al., 2014, Slattery et al., 2014, Sopko et al., 2014, Wang et al., 2014, Aleksic et al., 2013, Bonke et al., 2013, Djiane et al., 2013, Geisbrecht et al., 2013, Gunawan et al., 2013, Guo et al., 2013, Hombría and Serras, 2013, Hombría and Sotillos, 2013, Mbodj et al., 2013, McKay and Lieb, 2013, Morillo Prado et al., 2013, Morin-Poulard et al., 2013, Radyuk et al., 2013, Ren et al., 2013, Schertel et al., 2013, Shen et al., 2013, Woodfield et al., 2013, Zhang et al., 2013, Zoranovic et al., 2013, Aranjuez et al., 2012, Grönholm et al., 2012, Kvon et al., 2012, Larson et al., 2012, Lim et al., 2012, Rajan and Perrimon, 2012, Spokony and White, 2012.5.22, Winbush et al., 2012, Wong and Jones, 2012, Abruzzi et al., 2011, Casper et al., 2011, Copf et al., 2011, Jiang et al., 2011, Johnson et al., 2011, Nègre et al., 2011, Singh et al., 2011, Takashima et al., 2011, Tsurumi et al., 2011, Weake et al., 2011, Yan et al., 2011, Aerts et al., 2010, Beebe et al., 2010, Bina et al., 2010, Ekas et al., 2010, Flaherty et al., 2010, Goto et al., 2010, Kallio et al., 2010, Lin et al., 2010, Ngo et al., 2010, Reddy et al., 2010, The modENCODE Consortium, 2010, The modENCODE Consortium, 2010, Wu et al., 2010, Zeng et al., 2010, Almudi et al., 2009, Avadhanula et al., 2009, Bertet et al., 2009, Buchon et al., 2009, Casper and Van Doren, 2009, Classen et al., 2009, Fujikawa et al., 2009, Gutierrez-Aviño et al., 2009, Hartmann et al., 2009, Hilger et al., 2009, Issigonis et al., 2009, Jiang et al., 2009, Shen et al., 2009, Wang and Huang, 2009, Christensen et al., 2008.4.15, Christensen et al., 2008.4.15, Christensen et al., 2008.4.15, Dougherty et al., 2008, Ekas et al., 2008, López-Onieva et al., 2008, Ni et al., 2008, Rivas et al., 2008, Takashima et al., 2008, Talamillo et al., 2008, Yasugi et al., 2008, Avila and Erickson, 2007, Ayala-Camargo et al., 2007, Ayala et al., 2007, Baeg et al., 2007, Bastock and Strutt, 2007, Beckstead et al., 2007, Beltran et al., 2007, Bianco et al., 2007, Brawley et al., 2007, Curtis et al., 2007, Kim et al., 2007, Minidorff et al., 2007, Minidorff et al., 2007, Nurminsky, 2007, Singh et al., 2007, Stahl et al., 2007, Yasugi et al., 2007, Egli et al., 2006, Hollien and Weissman, 2006, Keller, 2006, Molnar et al., 2006, Oishi et al., 2006, Payne and Braun, 2006, Shi et al., 2006, Decotto and Spradling, 2005, Moberg et al., 2005, Sage et al., 2005, Vaccari and Bilder, 2005, Wawersik et al., 2005, Wertheim et al., 2005, Yamashita et al., 2005, Rawlings et al., 2004, Wang et al., 2004, Kimbrell and Beutler, 2001)
                  Stat92e
                  (Khanna et al., 2017, Xu and Cherry, 2014, Sinha et al., 2013)
                  d-STAT
                  (Arnosti et al., 1996)
                  dSTAT
                  (Stratoulias and Heino, 2015, Delaney et al., 2006, Ochoa-Espinosa and Small, 2006, Baksa et al., 1997)
                  dSTAT92E
                  (Struffi et al., 2006)
                  dSTAT92E/marelle
                  (Zeidler and Perrimon, 2000)
                  dstat
                  (Kim et al., 2009)
                  l(3)06346
                  (Perrimon et al., 1996)
                  l(3)j6C8
                  mrL
                  (Jasper et al., 2002)
                  mrl
                  (Sotillos et al., 2010, Bertet et al., 2009, Gutierrez-Aviño et al., 2009, Luschnig et al., 2004, Luschnig et al., 2004, Li and Li, 2003, Li et al., 2002, Jinks et al., 2000, Li et al., 2000, Harrison and Perrimon, 1997, Hou et al., 1996)
                  mrl stat92E
                  (Fujioka et al., 1999)
                  pSTAT
                  (Herz et al., 2006)
                  stat
                  (Banisch et al., 2017, Tian et al., 2016, Shapiro-Kulnane et al., 2015, Cordero et al., 2014, Johnston, 2014, Lin et al., 2014, Zhou et al., 2014, Cordero et al., 2012, Jiang et al., 2011, Yoon et al., 2011, Leatherman and Dinardo, 2010, Reddy et al., 2010, Bertet et al., 2009, Gao et al., 2009, Jang et al., 2009, Sheng et al., 2009, Leatherman and DiNardo, 2008, Melani et al., 2008, Sotillos et al., 2008, Starz-Gaiano et al., 2008, Krzemień et al., 2007, Lovegrove et al., 2006, Nystul and Spradling, 2006, Silver et al., 2005, Yan et al., 1996)
                  stat92
                  (Lee et al., 2008)
                  stat92E
                  (Gultekin and Steller, 2019, Saadin and Starz-Gaiano, 2018, Katheder et al., 2017, Recasens-Alvarez et al., 2017, Terriente-Félix et al., 2017, Ren et al., 2015, Bausek and Zeidler, 2014, Jones and Srivastava, 2014, Maimon et al., 2014, Thomas and Strutt, 2014, Huang et al., 2013, Silver-Morse and Li, 2013, Sotillos et al., 2013, Wells et al., 2013, Zeidler and Bausek, 2013, Zhou and Luo, 2013, Ameres et al., 2011, Stec and Zeidler, 2011, Wang et al., 2011, Wright et al., 2011, Liu et al., 2010, Robinson et al., 2010, Singh et al., 2010, Cronin et al., 2009, Flaherty et al., 2009, Gilbert et al., 2009, Gilbert et al., 2009, González et al., 2009, Jacques et al., 2009, Liu et al., 2009, Ozdowski et al., 2009, Sheng et al., 2009, Betz et al., 2008, Copf and Preat, 2008, Rodrigues and Bach, 2008, Shi et al., 2008, Sotillos et al., 2008, Ayala et al., 2007, Bach et al., 2007, Gilbert et al., 2007, Luque and Milan, 2007, Pfleger et al., 2007, Rodrigues and Bach, 2007, Arbouzova, 2006, Brown et al., 2006, de las Heras and Casanova, 2006, Ekas et al., 2006, Karsten et al., 2006, Lovegrove et al., 2006, Morrison and Kimble, 2006, Mukherjee et al., 2006, Singh et al., 2006, Hombria et al., 2005, Mukherjee et al., 2005, Brawley and Matunis, 2004, Brawley et al., 2004, Sorrentino et al., 2004, Bach et al., 2003, Chen et al., 2003, Denef and Schupbach, 2003, Ghabrial et al., 2003, Li et al., 2003, Li et al., 2003, Ozdowski et al., 2003, Silver and Montell, 2003, Bach and Perrimon, 2002, Baksa et al., 2002, Callus and Mathey-Prevot, 2002, Chen et al., 2002, Castelli-Gair et al., 2001, Jackson, 2001, Kiger et al., 2001, Luo and Dearolf, 2001, Silver and Montell, 2001, Tulina and Matunis, 2001, Myrick and Dearolf, 2000, Williams, 2000, Zeidler et al., 2000, Eldon et al., 1999, Williams et al., 1999, Zeidler et al., 1999, Harrison et al., 1998, Mathey-Prevot and Perrimon, 1998, Hou and Perrimon, 1997)
                  stat92e
                  (Ray et al., 2017, Liu et al., 2015, Sinha et al., 2013, Wang et al., 2008)
                  stat92E
                  (Xie et al., 2005)
                  Name Synonyms
                  Marelle
                  (Morin-Poulard et al., 2013, Bertet et al., 2009, Keller, 2006, Park et al., 2003)
                  STAT92E
                  (Sabin et al., 2010)
                  Signal-transducer and activator of transcription protein
                  Signal-transducer and activator of transcription protein at 92E
                  Stat92E
                  (Palmer et al., 2018)
                  marelle
                  (Zeidler and Bausek, 2013, Starz-Gaiano and Montell, 2004, Kile et al., 2002, Manning et al., 2002, Kimbrell and Beutler, 2001, Li et al., 2000, Vasisht et al., 1998, Briscoe et al., 1996, Harrison and Perrimon, 1996, Hou et al., 1996, Hou et al., 1996, Melnick, 1995.11.6)
                  signal transducer and activator of transcription
                  (Montell, 2006)
                  signal transducers and activator of transcription
                  (Gutierrez-Aviño et al., 2009)
                  stat92E
                  (Eichhorn et al., 2016)
                  Secondary FlyBase IDs
                  • FBgn0010885
                  • FBgn0011396
                  • FBgn0015512
                  Datasets (1)
                  Study focus (1)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  • bait_protein
                  modENCODE_regulation_TFs
                  Genome-wide localization of transcription factors by ChIP-chip and ChIP-Seq.
                  References (783)