FlyBase Gene Report: Dmel\Stat92E

Comment: reference states 1 hr AEL

(Yan et al., 1996)

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 1 -- 5

organism | pair rule expression pattern

(Hou et al., 1996)

embryonic stage 3 -- 6

Comment: reference states 1-3 hr AEL

(Yan et al., 1996)

embryonic stage 4 -- 6

dorsal head epidermis anlage

(Fisher et al., 2012)

embryonic stage 5 -- 6

mesectoderm | subset

(Kearney et al., 2004)

embryonic stage 6

primordial germ cell

(Yan et al., 1996)

embryonic stage 7 -- 8

antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

organism | segment polarity expression pattern

(Fisher et al., 2012)

mesectoderm anlage | subset

(Kearney et al., 2004)

embryonic stage 8 -- 17

gonad

(Yan et al., 1996)

extended germ band stage

mesoderm

(Yan et al., 1996)

(Hou et al., 1996, Yan et al., 1996)

embryonic stage 9

ectoderm

(Liu et al., 2009)

mesoderm | striped

(Liu et al., 2009)

embryonic stage 9 -- 10

antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

dorsal epidermis primordium

Comment: reported as dorsal epidermis anlage

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

ventral epidermis primordium

(Fisher et al., 2012)

embryonic stage 9 -- 12

midline primordium

(Kearney et al., 2004)

embryonic stage 10

ectoderm | striped

(Liu et al., 2009)

visceral muscle | striped

(Liu et al., 2009)

embryonic stage 11

somatic muscle

(Liu et al., 2009)

visceral muscle

(Liu et al., 2009)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

clypeo-labral primordium

(Fisher et al., 2012)

dorsal epidermis primordium

(Fisher et al., 2012)

dorsal head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)

lateral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)

ventral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

tracheal primordium

(Fisher et al., 2012)

ventral epidermis primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic hindgut

(Fisher et al., 2012)

embryonic proventriculus

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

embryonic/larval muscle system

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 15 -- 17

embryonic/larval foregut

(Yan et al., 1996)

embryonic/larval hindgut

(Yan et al., 1996)

late third instar larval stage

lamina furrow

(Wang et al., 2011)

larval outer optic anlage

(Wang et al., 2011)

adult stage

adult mushroom body

(Copf et al., 2011)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

(Hou et al., 1996, Yan et al., 1996)

embryonic stage 15

embryonic/larval foregut

(Yan et al., 1996)

gonad | precursor

(Yan et al., 1996)

embryonic/larval hindgut

(Yan et al., 1996)

Additional Descriptive Data

Expression pattern inferred from unspecified enhancer trap line.

(Kearney et al., 2004)

Stat92E transcripts are detected at all stages on northern blots. They are detected at high and uniformly distributed levels by in situ hybridization in early syncytial and cellularizing embryos. During germ band extension they are detected in a striped pattern within every segment.

(Hou et al., 1996)

Stat92E transcripts are detected at all stages of development by northern blot. Stat92E transcripts are detected in very early embryos in a uniform pattern by in situ hybridization. At the blastoderm stage, expression is seen in seven stripes in a broad central domain as well as in clusters of cells in anterior and posterior terminal segments. At germ band extension, 14 stripes are seen, restricted to mesodermal tissue. After germ band retraction, expression is observed mainly in the foregut, the hingut and in gonadal precursor cells.

(Yan et al., 1996)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 9

organism | segment polarity expression pattern

(Chen et al., 2002)

embryonic stage 13 -- 15

male germline cell

(Sheng et al., 2009)

embryonic stage 15

gonad

Comment: male

(Wawersik et al., 2005)

embryonic stage 17

male germline cell | subset

(Sheng et al., 2009)

gonad | anterior

(Sheng et al., 2009)

first instar larval stage | male

hub cell

(Okegbe and DiNardo, 2011)

somatic cell of testis

(Okegbe and DiNardo, 2011)

male germline cell

(Okegbe and DiNardo, 2011)

first instar larval stage

male germline cell

Comment: hub-proximal

(Sheng et al., 2009)

second instar larval stage -- early third instar larval stage

larval outer optic anlage

(Wang et al., 2011)

third instar larval stage

wing hinge

(Hatini et al., 2013)

pleurum

(Hatini et al., 2013)

mesothoracic tergum | restricted

(Hatini et al., 2013)

adult stage

intestinal stem cell of posterior adult midgut epithelium

(Liu et al., 2010)

enteroblast of posterior adult midgut epithelium

(Liu et al., 2010)

calyx of adult mushroom body | restricted

(Copf et al., 2011)

Kenyon cell

(Copf et al., 2011)

adult brain

(Copf et al., 2011)

adult stage | male & spermatogenesis

cyst progenitor cell

(Issigonis et al., 2009)

male germline stem cell

(Issigonis et al., 2009)

oogenesis stage S5 -- S7

stretch follicle cell

• nucleus

(Xi et al., 2003)

polar follicle cell

• nucleus

(Xi et al., 2003)

centripetal follicle cell

• nucleus

(Xi et al., 2003)

border follicle cell

• nucleus

(Xi et al., 2003)

oogenesis stage S8

border follicle cell

(Monahan and Starz-Gaiano, 2013)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

At the third instar larval stage, Stat92E protein accumulates in the nucleus in the wing hinge and the anterior border of the notum. It accumulates in the cytoplasm in the wing pouch and most of the notum.

(Hatini et al., 2013)

The Stat92E expression in border follicle cell clusters overlaps Socs36E expression at stage S8.

(Monahan and Starz-Gaiano, 2013)

Stat92E is expressed widely in the adult brain. It localizes to Kenyon cell bodies and is also present in subdomains of the calyx. It is present in mushroom body cell bodies.

(Copf et al., 2011)

Stat92E protein is expressed the larval outer optic anlage from the second through late third larval instar. Expression is higher in in the lateral neuroepithelium, decreasing in medial cells.

(Wang et al., 2011)

Stat92E protein is expressed in ISCs and enteroblasts.

(Liu et al., 2010)

In testes, Stat92E protein is detected at higher levels in germline stem cells than in cyst progenitor cells.

(Issigonis et al., 2009)

Stat92E is found in male germline cells from embryonic stage 13. By mid stage 17, it is expressed in a subset of male germline cells localized to the anterior of the gonad. In early first instar larvae, phosphorylated Stat92E is restricted to hub-proximal germ cells.

(Sheng et al., 2009)

Stat92E is upregulated specifically in male, but not female, germ cells at the time of gonad formation. The activated (phosphorylated) form of Stat92E is also only detected in male germ cells. Stat92E expression in male germ cells in dependent on their association with the somatic gonad.

(Wawersik et al., 2005)

The Stat92E protein accumulates in the follicle cells of the polar regions and decreases toward the main body cells in the middle of the egg chamber in a pattern complementary to mirr expression.

(Xi et al., 2003)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytoplasmic side of apical plasma membrane

inferred from direct assay

(Sotillos et al., 2008)

located_in cytosol

inferred from direct assay

(Moore et al., 2020, Sotillos et al., 2008, Agaisse et al., 2003)

located_in nucleus

inferred from direct assay

(Moore et al., 2020, Sotillos et al., 2008, Agaisse et al., 2003, Kwon et al., 2000)

inferred from direct assay

(assigned by BHF-UCL )

(Li et al., 2009)

Expression Deduced from Reporters

Reporter: P{Stat92E-meso-EGFP.H-Stinger}

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 8 -- 14

mesoderm | segmentally repeated

(Liu et al., 2009)

embryonic stage 10

visceral mesoderm

(Liu et al., 2009)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Stat92E in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Stat92E

View exonic expression by tissue for Dmel\Stat92E

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0016917

DRscDB

42428/tissue=All

EMBL-EBI Single Cell Expression Atlas

FBgn0016917

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG4257-RD

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4257

Flygut - An atlas of the Drosophila adult midgut

FBgn0016917

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 30 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 49 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Stat92E

Transgenic constructs containing regulatory region of Stat92E

Aberrations (Deficiencies and Duplications) ( 4 )

Inferred from experimentation ( 4 )

Gene disrupted in

Df(3R)BSC516

(Christensen et al., 2008.4.15)

Df(3R)BSC517

(Christensen et al., 2008.4.15)

Df(3R)BSC518

(Christensen et al., 2008.4.15)

Df(3R)H-B79

(Spradling et al., 1999)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | embryonic stage, with Scer\GAL4^Tub.PU, Stat92E^85C9

lethal | embryonic stage, with Scer\GAL4^Tub.PU, Stat92E^{R442A.UASp.Tag:HA}

Stat92E^85C9

lethal | embryonic stage, with Scer\GAL4^Tub.PU, Stat92E^{R442K.UASp.Tag:HA}

Stat92E^85C9

lethal | embryonic stage, with Scer\GAL4^Tub.PU, Stat92E^{R442P.UASp.Tag:HA}

Stat92E^85C9

lethal | embryonic stage, with Scer\GAL4^Tub.PU, Stat92E^{Y711F.UASp.Tag:HA}

Stat92E^85C9

lethal | embryonic stage (with Df(3R)H-B79)

lethal | embryonic stage | recessive

Stat92E^85C9

lethal | embryonic stage | recessive | rescuable maternal effect

Stat92E⁰⁶³⁴⁶

lethal | first instar larval stage, with Scer\GAL4^Tub.PU, Stat92E^85C9

lethal | first instar larval stage, with Scer\GAL4^Tub.PU, Stat92E^{R442A.UASp.Tag:HA}

Stat92E^85C9

lethal | first instar larval stage, with Scer\GAL4^Tub.PU, Stat92E^{R442K.UASp.Tag:HA}

Stat92E^85C9

lethal | first instar larval stage, with Scer\GAL4^Tub.PU, Stat92E^{R442P.UASp.Tag:HA}

Stat92E^85C9

lethal | first instar larval stage, with Scer\GAL4^Tub.PU, Stat92E^{Y711F.UASp.Tag:HA}

Stat92E^85C9

lethal | first instar larval stage (with Df(3R)H-B79)

lethal | first instar larval stage | recessive

Stat92E^85C9

lethal | heat sensitive, with Scer\GAL4^dome-PG14

Stat92E^HMS00035

lethal | heat sensitive (with Stat92E^F)

Stat92E^j6C8

lethal | heat sensitive (with Stat92E^j6C8)

Stat92E^F

lethal | larval stage | recessive

Stat92E⁰⁶³⁴⁶

lethal | recessive

lethal - all die before end of pupal stage | heat sensitive (with Stat92E⁰⁶³⁴⁶)

Stat92E^F

lethal - all die before end of pupal stage | heat sensitive (with Stat92E^F)

Stat92E⁰⁶³⁴⁶

lethal - all die before end of pupal stage | somatic clone

Stat92E^85C9

lethal - all die during embryonic stage | germline clone | recessive | rescuable maternal effect

lethal - all die during embryonic stage | recessive

Stat92E⁴²

partially lethal - majority die, with Scer\GAL4^pnr-MD237

Stat92E^GD4492

partially lethal - majority die | somatic clone - Minute background, with Scer\FLP1^ey.PU

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Stat92E^GD4492

viable, with Scer\GAL4^tin.CΔ4

Stat92E^GD4492

Sterility

Allele

female sterile | heat sensitive (with Stat92E⁰⁶³⁴⁶)

Stat92E^F

female sterile | heat sensitive (with Stat92E^F)

Stat92E⁰⁶³⁴⁶

female sterile | recessive

Stat92E^F

fertile

Stat92E^EY10528

male sterile (with Stat92E⁰⁶³⁴⁶)

Stat92E^F

male sterile (with Stat92E^F)

Stat92E⁰⁶³⁴⁶

male sterile | heat sensitive (with Stat92E⁰⁶³⁴⁶)

Stat92E^F

male sterile | heat sensitive (with Stat92E^F)

Stat92E⁰⁶³⁴⁶

Other Phenotypes

Allele

abnormal immune response

Stat92E^HJ

abnormal immune response, with Scer\GAL4^crq.Unk

Stat92E^dsRNA.UAS

abnormal immune response, with Scer\GAL4^Hml.Δ

Stat92E^dsRNA.UAS

abnormal immune response | adult stage, with Scer\GAL4^how-24B

Stat92E^NIG.cUa

abnormal immune response | adult stage, with Scer\GAL4^NP5130

Stat92E^NIG.cUa

abnormal memory | adult stage, with Scer\GAL4^238Y

Stat92E^NIG.4257R

abnormal memory | adult stage | heat sensitive, with Scer\GAL4^ey-OK107, Scer\GAL80^ts.αTub84B

Stat92E^NIG.4257R

abnormal memory | adult stage | RU486 conditional, with Scer\GAL4^{Mef2.247.Switch}

abnormal mitotic cell cycle | maternal effect

Stat92E⁰⁶³⁴⁶

abnormal planar polarity | recessive | somatic clone

Stat92E^unspecified

abnormal size | adult stage, with Scer\GAL4^sd.PU

Stat92E^KK100519

abnormal size | adult stage | somatic clone - Minute background, with Scer\FLP1^ey.PU

abnormal size | somatic clone - Minute background | third instar larval stage

Stat92E^85C9

abnormal size | third instar larval stage, with Scer\GAL4^en-e16E

Stat92E^HMS00035

abnormal stress response | RU486 conditional, with Scer\GAL4^{Act5C.Switch.PR}

Stat92E^GD4492

decreased body size | adult stage, with Scer\GAL4^dome-PG14

Stat92E^HMS00035

decreased body size | adult stage, with Scer\GAL4^VGAT.PF

Stat92E^HMS00035

decreased cell number | adult stage, with Scer\GAL4^C587

Stat92E^HMS00035

decreased cell number | male | third instar larval stage, with Scer\GAL4^C587

Stat92E^GD4492

decreased fecundity | female | heat sensitive (with Stat92E⁰⁶³⁴⁶)

Stat92E^F

decreased fecundity | female | heat sensitive (with Stat92E^F)

Stat92E⁰⁶³⁴⁶

decreased occurrence of cell division | adult stage | conditional, with Scer\GAL4^how-24B

Stat92E^NIG.cUa

decreased occurrence of cell division | adult stage | conditional, with Scer\GAL4^NP5130

Stat92E^NIG.cUa

decreased occurrence of cell division | embryonic stage | male

Stat92E⁰⁶³⁴⁶

decreased size | adult stage, with Scer\GAL4^ey.PU

Stat92E^GD4492

embryonic/larval segmentation phenotype | embryonic stage

hyperplasia | dominant | third instar larval stage

Stat92E³⁹⁷

hyperplasia | larval stage, with Scer\GAL4^dpp.blk1

Stat92E^UAS.cUa

increased cell death | conditional | third instar larval stage

Stat92E³⁹⁷

increased cell death | third instar larval stage, with Scer\GAL4^en-e16E

Stat92E^HMS00035

increased cell number | adult stage, with Scer\GAL4^NP5130

Stat92E^JF01265

increased cell number | adult stage | conditional, with Scer\GAL4^Hml.Δ

Stat92E^dsRNA.UAS

increased occurrence of cell division | adult stage, with Scer\GAL4^NP5130

Stat92E^JF01265

majority die during P-stage | somatic clone - Minute background, with Scer\FLP1^ey.PU

melanotic mass phenotype | somatic clone, with Scer\GAL4^Act5C.PI

Stat92E^{ΔNΔC.UASp.Tag:HA}

pair rule phenotype

Stat92E^HJ

some die during embryonic stage | recessive

Stat92E⁴²

some die during embryonic stage | recessive | rescuable maternal effect

some die during embryonic stage | rescuable maternal effect

Stat92E⁰⁶³⁴⁶

some die during pupal stage, with Scer\GAL4^pnr-MD237

Stat92E^GD4492

some die during pupal stage | heat sensitive (with Stat92E⁰⁶³⁴⁶)

Stat92E^F

some die during pupal stage | heat sensitive (with Stat92E^F)

Stat92E⁰⁶³⁴⁶

some die during pupal stage | somatic clone

Stat92E^85C9

visible

visible, with Scer\GAL4^ey.PH

Stat92E^{ΔNΔC.UASp.Tag:HA}

visible, with Scer\GAL4^ey.PU

visible, with Scer\GAL4^pnr-MD237

Stat92E^GD4492

visible | adult stage, with Scer\GAL4^en-e16E

visible | adult stage, with Scer\GAL4^ey.PU

Stat92E^GD4492

visible | adult stage, with Scer\GAL4^sd.PU

Stat92E^KK100519

visible | dominant

Stat92E^HJ

visible | germline clone

Stat92E⁶³⁴⁹

visible | somatic clone

visible | somatic clone - Minute background

wild-type | germline clone

Stat92E⁰⁶³⁴⁶

wild-type | somatic clone

Stat92E⁰⁶³⁴⁶

Phenotype manifest in

Allele

abdominal 4 ventral denticle belt

Stat92E⁰⁶³⁴⁶

abdominal 4 ventral denticle belt | germline clone | maternal effect

Stat92E⁰⁶³⁴⁶

abdominal 5 ventral denticle belt

Stat92E⁰⁶³⁴⁶

abdominal 5 ventral denticle belt | germline clone | maternal effect

Stat92E⁰⁶³⁴⁶

abdominal 6 ventral denticle belt

Stat92E⁰⁶³⁴⁶

abdominal 7 ventral denticle belt

Stat92E⁰⁶³⁴⁶

abdominal 8 ventral denticle belt

Stat92E⁰⁶³⁴⁶

abdominal segment 5

Stat92E⁰⁶³⁴⁶

abdominal segment 8

Stat92E⁰⁶³⁴⁶

actin cytoskeleton | adult stage, with Scer\GAL4^{Stat92E-0092-G4}

Stat92E^JF01265

adult cuticle (with Stat92E⁰⁶³⁴⁶)

Stat92E^F

adult cuticle (with Stat92E^F)

Stat92E⁰⁶³⁴⁶

adult cuticle | somatic clone - Minute background, with Scer\FLP1^ey.PU

Stat92E^85C9

adult head | somatic clone - Minute background, with Scer\FLP1^ey.PU

adult midgut epithelium, with Scer\GAL4^NP5130

Stat92E^JF01265

adult pars intercerebralis, with Scer\GAL4^{Stat92E-0092-G4}

Stat92E^JF01265

adult segment

Stat92E^HJ

antenna | somatic clone

Stat92E^j6C8

axon

Stat92E⁰⁶³⁴⁶

border follicle cell

border follicle cell, with Scer\GAL4^slbo.2.6

Stat92E^UAS.cPa

border follicle cell (with Stat92E³⁹⁷), with Scer\GAL4^- :

Stat92E^EP3391

border follicle cell (with Stat92E^EP3391), with Scer\GAL4^- :

Stat92E³⁹⁷

border follicle cell | heat sensitive (with Stat92E⁰⁶³⁴⁶)

Stat92E^F

border follicle cell | heat sensitive (with Stat92E^EP3391)

Stat92E^F

border follicle cell | heat sensitive (with Stat92E^EP3391), with Scer\GAL4^- :

Stat92E^F

border follicle cell | heat sensitive (with Stat92E^F)

border follicle cell | heat sensitive (with Stat92E^F), with Scer\GAL4^- :

Stat92E^EP3391

border follicle cell | somatic clone

Stat92E⁰⁶³⁴⁶

central nervous system

Stat92E⁰⁶³⁴⁶

cuticle & adult external head | somatic clone

Stat92E^85C9

cyst cell of testis | heat sensitive (with Stat92E^F)

Stat92E^j6C8

cyst cell of testis | heat sensitive (with Stat92E^j6C8)

Stat92E^F

cyst progenitor cell | heat sensitive (with Stat92E⁰⁶³⁴⁶)

Stat92E^F

cyst progenitor cell | heat sensitive (with Stat92E^F)

Stat92E⁰⁶³⁴⁶

cyst progenitor cell | male | heat sensitive (with Stat92E^F)

Stat92E^j6C8

cyst progenitor cell | male | heat sensitive (with Stat92E^j6C8)

Stat92E^F

cyst progenitor cell | male | somatic clone

cyst progenitor cell | somatic clone

denticle belt | germline clone | rescuable maternal effect

Stat92E⁰⁶³⁴⁶

dorsal appendage (with Stat92E⁰⁶³⁴⁶)

Stat92E^F

dorsal appendage (with Stat92E^F)

Stat92E⁰⁶³⁴⁶

dorsal prothorax

Stat92E^F

ectoderm | extended germ band stage | germline clone

Stat92E⁰⁶³⁴⁶

egg chamber

Stat92E^j6C8

egg chamber (with Stat92E⁰⁶³⁴⁶)

Stat92E^F

egg chamber (with Stat92E^F)

Stat92E⁰⁶³⁴⁶

egg chamber | somatic clone

Stat92E^j6C8

embryonic/first instar larval cuticle

Stat92E⁰⁶³⁴⁶

embryonic/larval anterior spiracle (with Stat92E⁰⁶³⁴⁶)

Stat92E^F

embryonic/larval anterior spiracle (with Stat92E^F)

Stat92E⁰⁶³⁴⁶

embryonic/larval lymph gland | third instar larval stage

Stat92E³⁹⁷

embryonic/larval plasmatocyte | third instar larval stage

Stat92E³⁹⁷

embryonic/larval posterior spiracle

Stat92E⁰⁶³⁴⁶

embryonic/larval proventriculus

Stat92E⁰⁶³⁴⁶

embryonic/larval somatic muscle

Stat92E⁰⁶³⁴⁶

embryonic/larval somatic muscle | germline clone, with Scer\GAL4^en.PU, Stat92E⁰⁶³⁴⁶

Stat92E^UAS.cSa

embryonic/larval somatic muscle | germline clone, with Scer\GAL4^en.PU, Stat92E^UAS.cSa

Stat92E⁰⁶³⁴⁶

embryonic/larval tracheal system | germline clone

Stat92E⁰⁶³⁴⁶

embryonic abdominal segment

Stat92E^HJ

embryonic abdominal segment 2 | germline clone

Stat92E⁶³⁴⁹

embryonic abdominal segment 3 | germline clone

Stat92E⁶³⁴⁹

embryonic abdominal segment 4

Stat92E⁰⁶³⁴⁶

embryonic abdominal segment 4 | germline clone

Stat92E⁶³⁴⁹

embryonic abdominal segment 4 | non-rescuable maternal effect

Stat92E⁰⁶³⁴⁶

embryonic abdominal segment 5

Stat92E⁰⁶³⁴⁶

embryonic abdominal segment 5 | germline clone

Stat92E⁶³⁴⁹

embryonic abdominal segment 5 | maternal effect

Stat92E⁰⁶³⁴⁶

embryonic abdominal segment 5 | non-rescuable maternal effect

Stat92E⁰⁶³⁴⁶

embryonic abdominal segment 6 | germline clone

Stat92E⁶³⁴⁹

embryonic abdominal segment 7 | germline clone

Stat92E⁶³⁴⁹

embryonic abdominal segment 8 | germline clone

Stat92E⁶³⁴⁹

embryonic abdominal segment | germline clone | maternal effect

embryonic head

Stat92E⁰⁶³⁴⁶

embryonic hindgut | germline clone

Stat92E⁰⁶³⁴⁶

embryonic mesothoracic segment | germline clone

Stat92E⁶³⁴⁹

embryonic metathoracic segment | germline clone

Stat92E⁶³⁴⁹

embryonic prothoracic segment | germline clone

Stat92E⁶³⁴⁹

embryonic segment

enteroblast of posterior adult midgut epithelium, with Scer\GAL4^NP5130

Stat92E^JF01265

enterocyte, with Scer\GAL4^Tub.PU

Stat92E^JF01266

enterocyte | somatic clone

Stat92E³⁹⁷

epidermis

Stat92E^HJ

escort cell (with Stat92E⁰⁶³⁴⁶)

Stat92E^F

escort cell (with Stat92E^F)

Stat92E⁰⁶³⁴⁶

eye

eye, with Scer\GAL4^ey.PH

Stat92E^{ΔNΔC.UASp.Tag:HA}

eye, with Scer\GAL4^ey.PU

eye | somatic clone

eye | somatic clone - Minute background, with Scer\FLP1^ey.PU

Stat92E^85C9

eye disc | somatic clone

Stat92E^85C9

eye disc | somatic clone - Minute background

filzkorper

Stat92E⁰⁶³⁴⁶

filzkorper | germline clone | maternal effect

follicle cell | somatic clone

Stat92E^j6C8

germarium, with Scer\GAL4^C587

Stat92E^HMS00035

germarium (with Stat92E⁰⁶³⁴⁶)

Stat92E^F

germarium (with Stat92E^F)

Stat92E⁰⁶³⁴⁶

germarium | cell non-autonomous | somatic clone

Stat92E^j6C8

germline cell | embryonic stage | male

Stat92E⁰⁶³⁴⁶

germline stem cell (with Stat92E⁰⁶³⁴⁶)

Stat92E^F

germline stem cell (with Stat92E^F)

Stat92E⁰⁶³⁴⁶

gonad | embryonic stage | maternal effect

Stat92E⁰⁶³⁴⁶

gonad | male | third instar larval stage, with Scer\GAL4^C587

Stat92E^GD4492

head | somatic clone

Stat92E^85C9

hemocyte | adult stage, with Scer\GAL4^Hml.Δ

Stat92E^dsRNA.UAS

hindgut

Stat92E⁰⁶³⁴⁶

hindgut & nucleus

Stat92E⁰⁶³⁴⁶

imaginal disc

Stat92E^F

intestinal stem cell of posterior adult midgut epithelium, with Scer\GAL4^NP5130

Stat92E^JF01265

larval longitudinal connective

Stat92E⁰⁶³⁴⁶

larval optic anlage, with Scer\GAL4^c768

Stat92E^{ΔNΔC.UASp.Tag:HA}

leg (with Stat92E⁰⁶³⁴⁶)

Stat92E^F

leg (with Stat92E^F)

Stat92E⁰⁶³⁴⁶

male germline stem cell, with Scer\GAL4^nos.PU

Stat92E^HMS00035

male germline stem cell | cell autonomous | germline clone

male germline stem cell | germline clone

male germline stem cell | heat sensitive (with Stat92E⁰⁶³⁴⁶)

Stat92E^F

male germline stem cell | heat sensitive (with Stat92E^F)

male germline stem cell | heat sensitive (with Stat92E^j6C8)

Stat92E^F

male germline stem cell | third instar larval stage, with Scer\GAL4^C587

Stat92E^GD4492

melanotic mass | somatic clone, with Scer\GAL4^Act5C.PI

Stat92E^{ΔNΔC.UASp.Tag:HA}

mesothoracic segment

Stat92E⁰⁶³⁴⁶

mesothoracic tergum, with Scer\GAL4^pnr-MD237

Stat92E^GD4492

mesothoracic tergum | adult stage | ectopic, with Scer\GAL4^sd.PU

Stat92E^KK100519

mesothoracic tergum primordium | ectopic | third instar larval stage, with Scer\GAL4^sd.PU

Stat92E^KK100519

mesothoracic ventral denticle belt

Stat92E⁰⁶³⁴⁶

midgut, with Scer\GAL4^how-24B, Scer\GAL80^ts.αTub84B

Stat92E^NIG.cUa

midgut, with Scer\GAL4^NP5130, Scer\GAL80^ts.αTub84B

Stat92E^NIG.cUa

morphogenetic furrow | somatic clone

Stat92E^85C9

mouth hook | germline clone

Stat92E⁶³⁴⁹

ommatidium | somatic clone

Stat92E^unspecified

oocyte

Stat92E^j6C8

oocyte (with Stat92E⁰⁶³⁴⁶)

Stat92E^F

oocyte (with Stat92E^F)

Stat92E⁰⁶³⁴⁶

ovarian basement membrane (with Stat92E⁰⁶³⁴⁶)

Stat92E^F

ovarian basement membrane (with Stat92E^F)

Stat92E⁰⁶³⁴⁶

ovarian basement membrane | cell non-autonomous | somatic clone

Stat92E^j6C8

ovarian sheath cell (with Stat92E⁰⁶³⁴⁶)

Stat92E^F

ovarian sheath cell (with Stat92E^F)

Stat92E⁰⁶³⁴⁶

ovarian sheath cell | cell non-autonomous | somatic clone

Stat92E^j6C8

ovariole

Stat92E⁰⁶³⁴⁶

peripheral nervous system

Stat92E⁰⁶³⁴⁶

polar follicle cell

Stat92E^j6C8

posterior spiracle primordium | germline clone

Stat92E⁶³⁴⁹

presumptive embryonic/larval tracheal system

Stat92E⁰⁶³⁴⁶

primordial germ cell | maternal effect

Stat92E⁰⁶³⁴⁶

segment

segment of antenna | somatic clone - Minute background, with Scer\FLP1^ey.PU

Stat92E^85C9

spectrosome | cell non-autonomous | somatic clone

Stat92E^j6C8

spermathecum | increased number (with Stat92E⁰⁶³⁴⁶)

Stat92E^F

spermathecum | increased number (with Stat92E^F)

Stat92E⁰⁶³⁴⁶

spermatocyte | heat sensitive (with Stat92E⁰⁶³⁴⁶)

Stat92E^F

spermatocyte | heat sensitive (with Stat92E^F)

spermatocyte | heat sensitive (with Stat92E^j6C8)

Stat92E^F

spermatogonium | heat sensitive (with Stat92E⁰⁶³⁴⁶)

Stat92E^F

spermatogonium | heat sensitive (with Stat92E^F)

spermatogonium | heat sensitive (with Stat92E^j6C8)

Stat92E^F

stalk follicle cell (with Stat92E⁰⁶³⁴⁶)

Stat92E^F

stalk follicle cell (with Stat92E^F)

Stat92E⁰⁶³⁴⁶

stalk follicle cell | anterior | cell autonomous

Stat92E^j6C8

stalk follicle cell | cell autonomous

Stat92E⁰⁶³⁴⁶

stretch follicle cell | somatic clone

Stat92E⁰⁶³⁴⁶

symmetrical commissure

Stat92E⁰⁶³⁴⁶

telson

Stat92E⁰⁶³⁴⁶

terminal bouton | adult stage | increased number, with Scer\GAL4^{Stat92E-0092-G4}

Stat92E^JF01265

trachea

Stat92E^HJ

tracheal branch primordium | germline clone

Stat92E⁶³⁴⁹

tracheal pit

Stat92E⁰⁶³⁴⁶

tracheal system

trichogen cell, with Scer\GAL4^pnr-MD237

Stat92E^GD4492

wing, with Scer\GAL4^sd.PU

Stat92E^KK100519

wing, with Scer\GAL4^VGAT.PF

Stat92E^HMS00035

wing blade posterior compartment

Stat92E^HJ

wing disc, with Scer\GAL4^dpp.blk1

Stat92E^UAS.cUa

wing disc | conditional | third instar larval stage

Stat92E³⁹⁷

wing disc | third instar larval stage

Stat92E³⁹⁷

wing disc | third instar larval stage, with Scer\GAL4^en-e16E

Stat92E^HMS00035

wing disc posterior compartment | somatic clone - Minute background | third instar larval stage

Stat92E^85C9

wing disc posterior compartment | third instar larval stage, with Scer\GAL4^en-e16E

Stat92E^HMS00035

wing hinge primordium | third instar larval stage, with Scer\GAL4^NP3253

Stat92E^VDRC.cUa

wing hinge primordium | third instar larval stage, with Scer\GAL4^zfh2-MS209

Stat92E^VDRC.cUa

wing pouch | ectopic | third instar larval stage, with Scer\GAL4^ptc.PU

Stat92E^KK100519

wing vein

Stat92E^HJ

wing vein | ectopic

Stat92E^HJ

wing vein | ectopic, with Scer\GAL4^en-e16E

wing vein | ectopic (with Stat92E⁰⁶³⁴⁶)

Stat92E^F

wing vein | ectopic (with Stat92E^F)

Stat92E⁰⁶³⁴⁶

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (7)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\STAT5B

13 of 15

Yes

Hsap\STAT5A

12 of 15

Yes

Hsap\STAT6

9 of 15

Yes

Hsap\STAT1

4 of 15

Yes

Hsap\STAT2

3 of 15

Yes

Hsap\STAT3

3 of 15

Yes

Hsap\STAT4

3 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (7)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Stat5b

13 of 15

Yes

Mmus\Stat5a

12 of 15

Yes

Mmus\Stat6

9 of 15

Yes

Mmus\Stat2

3 of 15

Yes

Mmus\Stat3

3 of 15

Yes

Mmus\Stat4

3 of 15

Yes

Mmus\Stat1

2 of 15

Yes

Rattus norvegicus (Norway rat) (7)

Rnor\Stat5b

11 of 13

Yes

Rnor\Stat5a

9 of 13

Yes

Rnor\Stat6

9 of 13

Yes

Rnor\Stat2

4 of 13

Yes

Rnor\Stat1

3 of 13

Yes

Rnor\Stat3

3 of 13

Yes

Rnor\Stat4

2 of 13

Yes

Xenopus tropicalis (Western clawed frog) (7)

Xtro\stat5b

7 of 12

Yes

Xtro\stat6

6 of 12

Yes

Xtro\stat4

4 of 12

Yes

Xtro\stat1

3 of 12

Yes

Xtro\stat2

3 of 12

Yes

Xtro\stat3.1

3 of 12

Yes

Xtro\stat3.2

1 of 12

Yes

Danio rerio (Zebrafish) (8)

Drer\stat5a

12 of 15

Yes

Drer\stat5b

8 of 15

Yes

Drer\stat6

8 of 15

Yes

Drer\stat1a

4 of 15

Yes

Drer\stat1b

3 of 15

Yes

Drer\stat2

3 of 15

Yes

Drer\stat3

3 of 15

Yes

Drer\stat4

3 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (2)

Cele\sta-1

14 of 15

Yes

Cele\sta-2

3 of 15

Yes

Arabidopsis thaliana (thale-cress) (2)

Atha\SHA

1 of 9

Yes

Atha\SHB

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091902YD )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Dsuz\DS10_00011311

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA26501

Drosophila persimilis

Dper\GL24086

Drosophila willistoni

Dwil\GK22722

Drosophila virilis

Dvir\GJ24191

Drosophila mojavensis

Dmoj\GI10538

Drosophila grimshawi

Dgri\GH14167

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501UV )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17007499

Musca domestica

House fly

Mdoa\17012345

Glossina morsitans

Tsetse fly

Gmor\GMOY008510

Glossina morsitans

Tsetse fly

Gmor\GMOY003394

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_03653

Mayetiola destructor

Hessian fly

Mdes\Mdes006230

Aedes aegypti

Yellow fever mosquito

Aaeg\STAT1

Anopheles darlingi

American malaria mosquito

Adar\ADAC010176

Anopheles gambiae

Malaria mosquito

Agam\STAT2

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ016471

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ016469

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01MY )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA001739

Danaus plexippus

Monarch butterfly

Dple\DPOGS212956-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL007184

Apis florea

Little honeybee

Aflo\2687567828

Apis mellifera

Western honey bee

Amel\STAT92E-like

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP14982

Bombus terrestris

Buff-tailed bumblebee

Bter\15205579

Linepithema humile

Argentine ant

Lhum\LH26246

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG007751

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_08642

Tribolium castaneum

Red flour beetle

Tcas\Stat

Pediculus humanus

Human body louse

Phum\PHUM335200

Rhodnius prolixus

Kissing bug

Rpro\RPRC006502

Cimex lectularius

Bed bug

Clec\CLEC002611

Cimex lectularius

Bed bug

Clec\CLEC002610

Cimex lectularius

Bed bug

Clec\CLEC002609

Cimex lectularius

Bed bug

Clec\CLEC002612

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI002351

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI005642

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI44613

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_16675

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01KX )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR014120

Ixodes scapularis

Black-legged tick

Isca\ISCW005692

Stegodyphus mimosarum

African social velvet spider

Smim\KFM58134.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur36g00600

Tetranychus urticae

Two-spotted spider mite

Turt\tetur17g02010

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_97641

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G03O3 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Stat

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000004044

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000010308

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000025956

Gallus gallus

Domestic chicken

Ggal\STAT4

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000007651

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000003267

Gallus gallus

Domestic chicken

Ggal\STAT5B

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (0)

No records found.

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

Stat92E^{ΔNΔC.UASp.Tag:HA}

model of cancer

CEA with scrib^KK101128, RhoGEF2^HMS01118

(Tamori et al., 2016)

Potential Models Based on Orthology ( 8 )

Human Ortholog

Disease

Evidence

References

STAT5B; signal transducer and activator of transcription 5B

model of growth hormone insensitivity syndrome with immune dysregulation 1

IEA

(FlyBase, 2019-)

model of growth hormone insensitivity syndrome with immune dysregulation 2

IEA

(FlyBase, 2019-)

STAT1; signal transducer and activator of transcription 1

model of immunodeficiency 31A

IEA

(FlyBase, 2019-)

model of immunodeficiency 31B

IEA

(FlyBase, 2019-)

model of immunodeficiency 31C

IEA

(FlyBase, 2019-)

model of chronic mucocutaneous candidiasis

IEA

(FlyBase, 2019-)

STAT3; signal transducer and activator of transcription 3

model of hyper IgE recurrent infection syndrome 1

IEA

(FlyBase, 2019-)

STAT2; signal transducer and activator of transcription 2

model of immunodeficiency 44

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 12 )

Allele

Disease

Interaction

References

Stat92E^JF01265

ameliorates colorectal cancer

modeled by Uvrag^HMS01357

(Nagy et al., 2016)

Stat92E^ΔN.UAS

ameliorates chronic myeloid leukemia

modeled by Hsap\ABL1::Hsap\BCR^UAS.cBa

(Bernardoni et al., 2019)

Stat92E⁰⁶³⁴⁶

ameliorates cancer

modeled by Ras85D^V12.UAS, scrib¹

(Wu et al., 2010)

ameliorates chronic myeloid leukemia

modeled by Hsap\ABL1::Hsap\BCR^UAS.cBa

(Bernardoni et al., 2019)

ameliorates carcinoma

modeled by TSG101²

(Moberg et al., 2005)

modeled by Vps25^A3

(Vaccari and Bilder, 2005)

Stat92E³⁹⁷

ameliorates hematologic cancer

modeled by hop^T42

(Bausek and Zeidler, 2014)

modeled by hop^Tum

(Bailetti et al., 2019)

Stat92E^F

ameliorates hematologic cancer

modeled by hop^T42

(Bausek and Zeidler, 2014)

Stat92E^HJ

ameliorates colorectal cancer

modeled by Uvrag^HMS01357

(Nagy et al., 2016)

Stat92E^dsRNA.UAS

ameliorates rhabdoid cancer

modeled by Snr1^HMS00363, BacA\p35^UAS.cHa

(Xie et al., 2017)

Stat92E^{ΔNΔC.UASp.Tag:HA}

exacerbates cancer

modeled by l(2)gl^GD4047

(Tamori et al., 2016)

modeled by scrib^KK101128

(Tamori et al., 2016)

Stat92E^GD4492

ameliorates hematologic cancer

modeled by hop^Tum

(Bausek and Zeidler, 2014, Bina et al., 2010)

ameliorates colorectal cancer

modeled by Src42A^CA.UAS

(Cordero et al., 2014)

exacerbates Alzheimer's disease 1

modeled by Hsap\APP^{Aβ42.E693G.UAS.VTR}

(Ray et al., 2017)

Stat92E^KK100519

ameliorates cancer

modeled by l(2)gl^GD4047

(Tamori et al., 2016)

ameliorates hematologic cancer

modeled by hop^{UAS.ORF.Tag:HA}

(Terriente-Félix et al., 2017)

Stat92E^UAS.EGFP

ameliorates tauopathy

modeled by Hsap\MAPT^UAS.cWa

(Colodner and Feany, 2010)

Stat92E^UAS.cUa

exacerbates cancer

modeled by Hipk^UAS.Tag:HA

(Blaquiere et al., 2018)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

STAT5B; signal transducer and activator of transcription 5B

13 of 15

604260

STAT5A; signal transducer and activator of transcription 5A

12 of 15

601511

STAT6; signal transducer and activator of transcription 6

9 of 15

601512

STAT1; signal transducer and activator of transcription 1

4 of 15

600555

STAT2; signal transducer and activator of transcription 2

3 of 15

600556

immunodeficiency 44

STAT3; signal transducer and activator of transcription 3

3 of 15

102582

hyper IgE recurrent infection syndrome 1

STAT4; signal transducer and activator of transcription 4

3 of 15

600558

SYSTEMIC LUPUS ERYTHEMATOSUS, SUSCEPTIBILITY TO, 11; SLEB11

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

RNA-RNA

Physical Interaction

Assay

References

Stat92E - mir-279

immunohistochemistry, luminiscence technology, necessary binding region

(Yoon et al., 2011)

protein-protein

Physical Interaction

Assay

References

Stat92E - Ada2b

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Stat92E - Cdk2

anti bait coimmunoprecipitation, western blot, anti tag western blot

(Chen et al., 2003)

Stat92E - Cdk4

anti bait coimmunoprecipitation, anti tag western blot

(Chen et al., 2003)

Stat92E - Cnot4

anti bait coimmunoprecipitation, anti tag western blot

(Grönholm et al., 2012)

Stat92E - CycD

anti bait coimmunoprecipitation, anti tag western blot

(Chen et al., 2003)

Stat92E - D

two hybrid array

(Shokri et al., 2019)

Stat92E - Dsp1

(Kim et al., 2007)

Stat92E - HDAC1

proximity ligation assay, fluorescence microscopy

(Kim et al., 2007)

Stat92E - Hipk

(Tettweiler et al., 2019)

Stat92E - His1

pull down, anti tag western blot

(Xu et al., 2014)

Stat92E - Jra

anti tag coimmunoprecipitation, anti tag western blot

(Kim et al., 2007)

Stat92E - Socs36E

(Hoi et al., 2016)

Stat92E - Socs44A

anti tag coimmunoprecipitation, anti tag western blot

(Hoi et al., 2016)

Stat92E - Su(var)205

anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, anti tag western blot, pull down

(Xu et al., 2014, Shi et al., 2008)

Stat92E - Taf1

pull down, western blot, anti tag coimmunoprecipitation, autoradiography

(Panov et al., 2012)

Stat92E - baz

(Sotillos et al., 2013, Sotillos et al., 2008)

Stat92E - ci

anti tag coimmunoprecipitation, anti tag western blot

(Liu et al., 2015)

Stat92E - dome

anti bait coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation, western blot

(Fisher et al., 2016, Chen et al., 2002)

Stat92E - e(y)3

anti bait coimmunoprecipitation, western blot, molecular sieving, anti tag coimmunoprecipitation, anti tag western blot

(Panov et al., 2012)

Stat92E - et

anti bait coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation, western blot

(Fisher et al., 2016)

Stat92E - hop

anti tag coimmunoprecipitation, anti tag western blot

(Hoi et al., 2016)

Stat92E - mor

View in Interactions Browser

(Panov et al., 2012)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

BHD

(Singh et al., 2006)

Csk|Stat92E

suppressible

Btk29A

(Read et al., 2004)

enhanceable

Csk

(Read et al., 2004)

suppressible

Diap1

(Betz et al., 2008)

enhanceable

dome

(Brown et al., 2001)

suppressible

dpp

(Singh et al., 2006)

enhanceable

hop

(Zeidler et al., 1999)

suppressible

hop

(Luo et al., 1997, Yan et al., 1996)

enhanceable

(Li et al., 2003)

enhanceable

(Singh et al., 2010)

suppressible

Sox21a

(Zhai et al., 2015)

Stat92E|Src42A

enhanceable

Src64B

(Sotillos et al., 2013)

suppressible

(Ekas et al., 2006)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

apt

suppressible

(Starz-Gaiano et al., 2008)

suppressible

(Tsai et al., 2015)

bip1

suppressible

(Mondal et al., 2014)

suppressible

(Liu et al., 2015)

cic|tor|trk

suppressible

(de las Heras and Casanova, 2006)

Csk

enhanceable

(Read et al., 2004)

csw

enhanceable

(Oishi et al., 2006)

dome

enhanceable

(Ghiglione et al., 2002, Brown et al., 2001)

Egfr::tor

suppressible

(Buchon et al., 2010)

suppressible

(Li and Li, 2003)

suppressible

(Herranz et al., 2012)

gcm

suppressible

(Jacques et al., 2009)

Hipk

enhanceable

(Blaquiere et al., 2018)

Hipk

suppressible

(Tettweiler et al., 2019)

hop

suppressible

(Bausek and Zeidler, 2014, Bina et al., 2010, Muller et al., 2005, Remillieux-Leschelle et al., 2002, Luo et al., 1997, Hou et al., 1996, Yan et al., 1996, Yan et al., 1996)

Kdm5

enhanceable

(Tarayrah et al., 2015)

Kdm5

suppressible

(Tarayrah et al., 2015)

l(2)gl

suppressible

(Tamori et al., 2016)

l(2)gl

enhanceable

(Tamori et al., 2016)

suppressible

(Wang and Huang, 2009)

Ptp61F

suppressible

(Buszard et al., 2013)

Rabex-5

suppressible

(Thomas and Strutt, 2014)

suppressible

(Silver, 2005)

enhanceable

(Li et al., 2003)

suppressible

(Wu et al., 2010)

suppressible

(Gultekin and Steller, 2019)

scrib

enhanceable

(Tamori et al., 2016)

slbo

suppressible

(Beccari et al., 2002)

suppressible

(Liu et al., 2015)

suppressible

(Xie et al., 2017)

enhanceable

(Callus and Mathey-Prevot, 2002)

Src42A

suppressible

(Cordero et al., 2014)

Su(var)2-10

suppressible

(Betz et al., 2001)

Su(var)2-10

enhanceable

(Betz et al., 2001)

Sulf1

suppressible

(Takemura and Nakato, 2017)

suppressible

(Remillieux-Leschelle et al., 2002)

tor

suppressible

(Li and Li, 2003, Li et al., 2002)

TSG101

suppressible

(Moberg et al., 2005)

tsl

suppressible

(de las Heras and Casanova, 2006)

suppressible

(Lee et al., 2008)

suppressible

(Mukherjee et al., 2006, Muller et al., 2005, Read et al., 2004, Tsai and Sun, 2004, Bach et al., 2003)

upd3

enhanceable

(Wang et al., 2014)

Uvrag

suppressible

(Nagy et al., 2016)

Vps25

suppressible