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General Information
Symbol
Dmel\Stat92E
Species
D. melanogaster
Name
Signal-transducer and activator of transcription protein at 92E
Annotation Symbol
CG4257
Feature Type
FlyBase ID
FBgn0016917
Gene Model Status
Stock Availability
Gene Snapshot
Signal-transducer and activator of transcription protein at 92E (Stat92E) encodes a transcription factor that shuttles between the cytosol and nucleus and functions in the JAK/STAT pathway. Its roles include proliferation, growth control, organismal metabolism, cell competition, stem cell self-renewal, immunity and developmental patterning. [Date last reviewed: 2019-03-14]
Also Known As
STAT, marelle, mrl, D-STAT, Dstat
Key Links
Genomic Location
Cytogenetic map
Sequence location
3R:20,535,323..20,552,311 [-]
Recombination map
3-69
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Protein Family (UniProt)
Belongs to the transcription factor STAT family. (Q24151)
Summaries
Gene Group (FlyBase)
OTHER DNA BINDING DOMAIN TRANSCRIPTION FACTORS -
The Other DNA binding domain transcription factors group is a collection of DNA-binding transcription factors that do not fit into any of the other major domain-based transcription factor groups.
Pathway (FlyBase)
JAK-STAT Signaling Pathway Core Components -
The JAK-STAT signaling pathway is initiated by the binding of an extracellular ligand to a cell surface receptor leading to receptor dimerization and the intracellular activation of a Janus kinase (JAK) family member. JAK phosphorylates cytoplasmic STAT family members which dimerize, translocate into the nucleus and regulate target gene expression. In Drosophila, the core pathway is limited to three ligands (the Unpaired family of cytokines), a single receptor (dome), JAK kinase (hop) and STAT (Stat92E). (Adapted from FBrf0225259).
Protein Function (UniProtKB)
Signal transduction and activation of transcription. Plays an important role in the segmental pattern formation in the early embryo by activating specific stripes of pair rule gene expression. The Janus kinase-STAT pathway is connected to drosophila early development.
(UniProt, Q24151)
Summary (Interactive Fly)
transcription factor - cytoplasmic signal transducing protein - regulates the stripe 3 promoter and the pair rule gene - central to the establishment of planar polarity during Drosophila eye development
Gene Model and Products
Number of Transcripts
11
Number of Unique Polypeptides
7

Please see the GBrowse view of Dmel\Stat92E or the JBrowse view of Dmel\Stat92E for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.47
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0089484
3595
628
FBtr0089485
4008
754
FBtr0089487
3852
754
FBtr0089486
3873
761
FBtr0100457
3616
635
FBtr0334581
3830
635
FBtr0334582
3879
679
FBtr0334583
4023
811
FBtr0334584
4200
818
FBtr0334585
2917
679
FBtr0334586
4029
761
Additional Transcript Data and Comments
Reported size (kB)
4.0 (northern blot)
4 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0088487
71.2
628
6.20
FBpp0088488
85.6
754
6.24
FBpp0088978
85.6
754
6.24
FBpp0088489
86.4
761
6.05
FBpp0099882
72.0
635
5.98
FBpp0306648
72.0
635
5.98
FBpp0306649
76.8
679
5.62
FBpp0306650
91.8
811
5.63
FBpp0306651
92.6
818
5.44
FBpp0306652
76.8
679
5.62
FBpp0306653
86.4
761
6.05
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

754 aa isoforms: Stat92E-PC, Stat92E-PE
761 aa isoforms: Stat92E-PF, Stat92E-PM
635 aa isoforms: Stat92E-PG, Stat92E-PH
679 aa isoforms: Stat92E-PI, Stat92E-PL
Additional Polypeptide Data and Comments
Reported size (kDa)
761 (aa); 86 (kD predicted)
Comments
External Data
Subunit Structure (UniProtKB)
Forms a homodimer or a heterodimer with a related family member.
(UniProt, Q24151)
Post Translational Modification
Tyrosine phosphorylated by hopscotch. Phosphorylation is required for DNA-binding activity and dimerization.
(UniProt, Q24151)
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Stat92E using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Gene Ontology (45 terms)
Molecular Function (6 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
inferred from physical interaction with UniProtKB:M9NE35
inferred from physical interaction with UniProtKB:Q9VWE0
inferred from direct assay
inferred from physical interaction with UniProtKB:A1Z7P5
inferred from physical interaction with FLYBASE:Cdk2; FB:FBgn0004107
inferred from physical interaction with FLYBASE:Cdk4; FB:FBgn0016131
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from sequence or structural similarity with HGNC:11366
inferred from sequence or structural similarity with HGNC:11368
inferred from biological aspect of ancestor with PANTHER:PTN000210448
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000210448
(assigned by GO_Central )
Biological Process (35 terms)
Terms Based on Experimental Evidence (30 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from expression pattern
inferred from mutant phenotype
inferred from direct assay
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:bip1; FB:FBgn0026263
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:Rel; FB:FBgn0014018
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from direct assay
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
Terms Based on Predictions or Assertions (7 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000927860
(assigned by GO_Central )
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN000210448
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000927860
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000927860
(assigned by GO_Central )
Cellular Component (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
inferred from direct assay
(assigned by BHF-UCL )
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000210448
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000210448
(assigned by GO_Central )
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism | ubiquitous

Comment: reference states 1 hr AEL

organism

Comment: maternally deposited

antennal anlage

Comment: reported as procephalic ectoderm anlage

central brain anlage

Comment: reported as procephalic ectoderm anlage

dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

visual anlage

Comment: reported as procephalic ectoderm anlage

antennal primordium

Comment: reported as procephalic ectoderm primordium

central brain primordium

Comment: reported as procephalic ectoderm primordium

visual primordium

Comment: reported as procephalic ectoderm primordium

dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

dorsal epidermis primordium

Comment: reported as dorsal epidermis anlage

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Expression pattern inferred from unspecified enhancer trap line.
Stat92E transcripts are detected at all stages on northern blots. They are detected at high and uniformly distributed levels by in situ hybridization in early syncytial and cellularizing embryos. During germ band extension they are detected in a striped pattern within every segment.
Stat92E transcripts are detected at all stages of development by northern blot. Stat92E transcripts are detected in very early embryos in a uniform pattern by in situ hybridization. At the blastoderm stage, expression is seen in seven stripes in a broad central domain as well as in clusters of cells in anterior and posterior terminal segments. At germ band extension, 14 stripes are seen, restricted to mesodermal tissue. After germ band retraction, expression is observed mainly in the foregut, the hingut and in gonadal precursor cells.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
The Stat92E expression in border follicle cell clusters overlaps Socs36E expression at stage S8.
Stat92E is expressed widely in the adult brain. It localizes to Kenyon cell bodies and is also present in subdomains of the calyx. It is present in mushroom body cell bodies.
Stat92E protein is expressed the larval outer optic anlage from the second through late third larval instar. Expression is higher in in the lateral neuroepithelium, decreasing in medial cells.
Stat92E protein is expressed in ISCs and enteroblasts.
In testes, Stat92E protein is detected at higher levels in germline stem cells than in cyst progenitor cells.
Stat92E is found in male germline cells from embryonic stage 13. By mid stage 17, it is expressed in a subset of male germline cells localized to the anterior of the gonad. In early first instar larvae, phosphorylated Stat92E is restricted to hub-proximal germ cells.
The Stat92E protein accumulates in the follicle cells of the polar regions and decreases toward the main body cells in the middle of the egg chamber in a pattern complementary to mirr expression.
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
inferred from direct assay
(assigned by BHF-UCL )
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Stat92E in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 29 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 46 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Stat92E
Transgenic constructs containing regulatory region of Stat92E
Deletions and Duplications ( 4 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
cuticle & adult external head | somatic clone
hindgut & nucleus
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
12 of 15
Yes
Yes
11 of 15
No
Yes
8 of 15
No
Yes
3 of 15
No
Yes
 
3 of 15
No
Yes
3 of 15
No
Yes
 
3 of 15
No
Yes
 
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
12 of 15
Yes
Yes
11 of 15
No
Yes
7 of 15
No
Yes
3 of 15
No
Yes
3 of 15
No
Yes
3 of 15
No
Yes
2 of 15
No
Yes
Rattus norvegicus (Norway rat) (7)
10 of 13
Yes
Yes
8 of 13
No
Yes
6 of 13
No
Yes
4 of 13
No
Yes
3 of 13
No
Yes
2 of 13
No
Yes
2 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (6)
5 of 12
Yes
Yes
3 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
Danio rerio (Zebrafish) (8)
11 of 15
Yes
Yes
8 of 15
No
Yes
7 of 15
No
Yes
3 of 15
No
Yes
3 of 15
No
Yes
3 of 15
No
Yes
3 of 15
No
Yes
3 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (2)
11 of 15
Yes
Yes
2 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (1)
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (2)
1 of 15
Yes
Yes
1 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091902YD )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501UV )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01MY )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01KX )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G03O3 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 2 )
    Modifiers Based on Experimental Evidence ( 10 )
    Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
     
    In a tuberculosis model by abdominal injection with Mycobacterium marinum, adult flies expressing Stat92EdsRNA.Scer\UAS under the control of: Scer\GAL4crq.Unk, in combination with gal80[ts] to restrict expression to adulthood, present a significant decrease in the bacterial burden, and a significant increase in the survival, as compared to wild-type control flies; Scer\GAL4Hml.Δ, in combination with gal80[ts] to restrict expression to adulthood, present a significant increase in the hemocyte numbers at day 6, but not day 5, after infection, as compared to wild-type control flies; Scer\GAL4c564 present similar survival, as compared to wild-type control flies.
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    RNA-RNA
    Physical Interaction
    Assay
    References
    protein-protein
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Subunit Structure (UniProtKB)
    Forms a homodimer or a heterodimer with a related family member.
    (UniProt, Q24151 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    JAK-STAT Signaling Pathway Core Components -
    The JAK-STAT signaling pathway is initiated by the binding of an extracellular ligand to a cell surface receptor leading to receptor dimerization and the intracellular activation of a Janus kinase (JAK) family member. JAK phosphorylates cytoplasmic STAT family members which dimerize, translocate into the nucleus and regulate target gene expression. In Drosophila, the core pathway is limited to three ligands (the Unpaired family of cytokines), a single receptor (dome), JAK kinase (hop) and STAT (Stat92E). (Adapted from FBrf0225259).
    External Data
    Linkouts
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3R
    Recombination map
    3-69
    Cytogenetic map
    Sequence location
    3R:20,535,323..20,552,311 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    92F1-92F1
    Limits computationally determined from genome sequence between P{PZ}l(3)1058510585 and P{EP}SyndEP409
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    92E2-92E2
    92E2-92E4
    (determined by in situ hybridisation)
    92E-92E
    (determined by in situ hybridisation)
    92E2-92E2
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (23)
    Genomic Clones (24)
    cDNA Clones (205)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for identity of: Stat92E CG4257
    Source for database merge of
    Additional comments
    Other Comments
    DNA-protein interactions: genome-wide binding profile assayed for Stat92E protein in 0-12 hr embryos; see mE1_TFBS_Stat92E collection report.
    dsRNA made from templates generated with primers directed against this gene.
    dsRNA made from templates generated with primers directed against this gene used in a cell-based RNAi assay to identify components or modifiers of the JAK/STAT pathway.
    Treatment of S2-derived S2-NP cells with dsRNA made from templates generated with primers directed against Stat92E results in a 12-24-fold decrease in JAK/STAT activity.
    dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
    Stat92E is involved in proper differentiation and morphogenesis of multiple tissues.
    Stat92E acts downstream of the Dl/N pathway to induce the differentiation of the interfollicle (or stalk) cells. Stalks cause the polarization of adjacent anterior egg chambers by inducing shape change and preferential adhesion that positions the oocyte at the posterior.
    Stat92E function is necessary for the proper differentiation of the polar follicle cells and the interfollicle cells. The failure of these cell to differentiate correctly leads to fused egg chambers and results in female sterility. Stat92E is part of an intracellular Jak-Stat signalling pathway and is activated by the hop Jak kinase. Partial loss of hop gene product activity gives a phenotype similar to that of Stat92E mutants, supporting the idea that the Jak-Stat pathway is involved in regulation of oogenesis.
    Stat92E is required autonomously in the germ cells for germline stem cell maintenance.
    Stat92E is required for border cell migration.
    Stat92E is required in the male germline for maintenance of germ line stem cell renewal.
    Dominant hop mutations cause hop to be a hyperactive kinase that can cause hyperactivation of the hop Stat92E pathway.
    Stat92E acts downstream of the hop kinase and encodes a protein similar to the mammalian Stat proteins. hop may activate Stat92E to regulate transcription of target genes such as eve. Stat92E is epistatic to hop.
    The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(whs)} P{hsFLP} chromosomes) has been used to identify the specific maternal effect phenotype for the zygotic lethal mutation.
    Stat92E has been identified both by molecular and genetic strategies. A mutation in Stat92E has been identified by suppression of a hop mutant phenotype. Two binding sites for Stat92E protein have been identified in the eve stripe 3 enhancer region.
    An allele of Stat92E was identified in a screen for second site suppressors of hopTum. Stat92E is involved in wing vein and trachea development, and segmentation in embryos and adults.
    A unique binding activity that resembles the Stat-like activity of the mammalian system is identified in Drosophila and is encoded by pp100 and pp150 polypeptides. Vanadate/hydrogen peroxide treatment of Schneider cells induces a specific GRR binding complex whose formation is dependent upon Tyr phosphorylation.
    Origin and Etymology
    Discoverer
    Etymology
    "marelle" is French for "hopscotch".
    Identification
    External Crossreferences and Linkouts ( 162 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    KEGG Genes - Molecular building blocks of life in the genomic space.
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    modMine - A data warehouse for the modENCODE project
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DPiM - Drosophila Protein interaction map
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyMine - An integrated database for Drosophila genomics
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (45)
    Reported As
    Symbol Synonym
    D-stat/stat92E
    STAT
    (Lin et al., 2019, Kang et al., 2018, Prange et al., 2018, Ferguson and Martinez-Agosto, 2017, Mussabekova et al., 2017, Zhao and Karpac, 2017, Deshpande et al., 2016, Kotov et al., 2016, Kwon et al., 2016, Niwa and Niwa, 2016, Saadin and Starz-Gaiano, 2016, Verghese and Su, 2016, Yadav et al., 2016, Dorn and Dorn, 2015, Qian et al., 2015, Ren et al., 2015, Sun et al., 2015, Thomas et al., 2015, Zhou et al., 2015, Mannervik, 2014, Mondal et al., 2014, Tipping and Perrimon, 2014, Zhou et al., 2014, Ferrandon, 2013, Gonzalez, 2013, Huang et al., 2013, Kingsolver et al., 2013, Monahan and Starz-Gaiano, 2013, Woodfield et al., 2013, Zhang et al., 2013, Zhou et al., 2013, Hayashi et al., 2012, Jemc et al., 2012, Osman et al., 2012, Vanha-Aho et al., 2012, Gonsalves et al., 2011, Tsurumi et al., 2011, Yan et al., 2011, Yoon et al., 2011, Zheng et al., 2011, Buchon et al., 2010, Colodner and Feany, 2010, Buchon et al., 2009, Gutierrez-Aviño et al., 2009, Starz-Gaiano et al., 2009, Wang and Huang, 2009, Ayala and Bach, 2008, Baudot et al., 2008, Cinnamon et al., 2008, Copf and Preat, 2008, Han and Harrison, 2008, Issigonis et al., 2008, McConnell et al., 2008, McDonald et al., 2008, Pastor-Pareja et al., 2008, Starz-Gaiano et al., 2008, Wawersik et al., 2008, Yasugi et al., 2008, Devergne et al., 2007, Eleftherianos et al., 2007, Kimble and Page, 2007, Kronhamn et al., 2007, Krzemien et al., 2007, Rivas et al., 2007, Shi et al., 2007, Sotillos and Castelli-Gair, 2007, Tsai et al., 2007, Bartscherer et al., 2006, Borghese et al., 2006, Castelli-Gair Hombria, 2006, DEVERGNE and NOSELLI, 2006, Montell, 2006, Sheng et al., 2006, Brawley et al., 2005, Brown et al., 2005, Dostert et al., 2005, Ip, 2005, Sheng et al., 2005, Beachy et al., 2004, Ohlstein et al., 2004, Terry et al., 2004, Wawersik et al., 2004, Agaisse et al., 2003, Feix et al., 2003, Gilbert et al., 2003, Hultmark and Ekengren, 2003, Mukherjee and Zeidler, 2003, Seyedoleslami Esfahani et al., 2003, Solnica-Krezel and Eaton, 2003, Castelli-Gair Hombria and Brown, 2002, Kisseleva et al., 2002, Lavine and Strand, 2002, Rawlings and Harrison, 2002, Rorth, 2002, Silver and Montell, 2002, Matunis and Tulina, 2001, Mushegian and Medzhitov, 2001, Wasserman and DiNardo, 2001, Khush and Lemaitre, 2000, Meister et al., 2000, Blair, 1999, Perrimon and Stern, 1999, Zeidler et al., 1999, Mathey-Prevot et al., 1998, Zeidler and Perrimon, 1998)
    STAT92E
    (Bernardoni et al., 2019, Camara et al., 2019, Ho et al., 2019, Sreejith et al., 2019, Wang et al., 2019, Yang et al., 2019, Ahmed-de-Prado and Baonza, 2018, Fisher et al., 2018, Mehrotra and Deshpande, 2018, Yu et al., 2018, Khanna et al., 2017, Lu et al., 2017, Purice et al., 2017, Takemura and Nakato, 2017, Willoughby et al., 2017, Winfree et al., 2017, Xie et al., 2017, Bayona-Feliu et al., 2016, Musashe et al., 2016, Tamori et al., 2016, Boija and Mannervik, 2015, Freeman, 2015, Glassford et al., 2015, Grifoni et al., 2015, Housden et al., 2015, Li et al., 2015, Ren et al., 2015, Tsai et al., 2015, Kux and Pitsouli, 2014, Li et al., 2014, Wang et al., 2014, Xu et al., 2014, You et al., 2014, Bausek, 2013, Buszard et al., 2013, Morin-Poulard et al., 2013, Oldefest et al., 2013, Silver-Morse and Li, 2013, Stec et al., 2013, Wang et al., 2013, Zeidler and Bausek, 2013, Zoranovic et al., 2013, Amoyel and Bach, 2012, Bier and Guichard, 2012, Igboin et al., 2012, Jemc et al., 2012, Luo and Sehgal, 2012, Panov et al., 2012, Crozatier and Vincent, 2011, Kim et al., 2011, Li et al., 2011, Rodriguez, 2011, Stec and Zeidler, 2011, Tsurumi et al., 2011, Grönholm et al., 2010, Sotillos et al., 2010, Benítez et al., 2009, Buchon et al., 2009, Gutierrez-Aviño et al., 2009, Li et al., 2009, Sheng et al., 2009, Kim et al., 2008, Nallamothu et al., 2008, Shi et al., 2008, Assa-Kunik et al., 2007, Betz et al., 2007, Sheng et al., 2007, Silver et al., 2007, Arbouzova and Zeidler, 2006, Arbouzova et al., 2006, Wang et al., 2006, Baeg et al., 2005, Gesellchen et al., 2005, Kai et al., 2005, Reynolds-Kenneally and Mlodzik, 2005, Agaisse and Perrimon, 2004, Karsten et al., 2004, Mukherjee et al., 2004, Ren et al., 2004, Starz-Gaiano and Montell, 2004, Tsai and Sun, 2004, Arbouzova et al., 2003, Chen et al., 2003, Lemaitre, 2000.12.20)
    Stat1α-like
    Stat92E
    (Bailetti et al., 2019, Chai et al., 2019, Gultekin and Steller, 2019, La Marca et al., 2019, Powers and Srivastava, 2019, Reedy et al., 2019, Shokri et al., 2019, Sinha et al., 2019, Wang et al., 2019, Wittes and Schüpbach, 2019, Xu et al., 2019, Ahmed-de-Prado et al., 2018, Green et al., 2018, Hao et al., 2018, Yu and Pan, 2018, Barr et al., 2017, Feng et al., 2017, Lee et al., 2017, Pascual et al., 2017, Péan et al., 2017, Torres et al., 2017, Transgenic RNAi Project members, 2017-, Tsurumi et al., 2017, Atkins et al., 2016, Clandinin and Owens, 2016-, Harris et al., 2016, Hoi et al., 2016, Kwon et al., 2016, Mbodj et al., 2016, Monahan and Starz-Gaiano, 2016, Moulton and Letsou, 2016, Nagy et al., 2016, Padash Barmchi et al., 2016, Purice et al., 2016, Saadin and Starz-Gaiano, 2016, Saha et al., 2016, Shen et al., 2016, Verghese and Su, 2016, Aradska et al., 2015, Kohlmaier et al., 2015, Moreno et al., 2015, Moskalev et al., 2015, Schertel et al., 2015, Seeds et al., 2015, Sopko et al., 2015, Terhzaz et al., 2015, Van Bortle et al., 2015, Woodcock et al., 2015, Xia et al., 2015, Zhai et al., 2015, Boyle et al., 2014, Chabu and Xu, 2014, Chen et al., 2014, Doherty et al., 2014, Issman-Zecharya and Schuldiner, 2014, Jiang and Singh, 2014, Lee et al., 2014, Salazar-Jaramillo et al., 2014, Slattery et al., 2014, Sopko et al., 2014, Wang et al., 2014, Aleksic et al., 2013, Bonke et al., 2013, Djiane et al., 2013, Geisbrecht et al., 2013, Gunawan et al., 2013, Guo et al., 2013, Hombría and Serras, 2013, Hombría and Sotillos, 2013, Mbodj et al., 2013, McKay and Lieb, 2013, Morillo Prado et al., 2013, Morin-Poulard et al., 2013, Radyuk et al., 2013, Ren et al., 2013, Schertel et al., 2013, Shen et al., 2013, Woodfield et al., 2013, Zhang et al., 2013, Zoranovic et al., 2013, Aranjuez et al., 2012, Grönholm et al., 2012, Kvon et al., 2012, Larson et al., 2012, Lim et al., 2012, Rajan and Perrimon, 2012, Spokony and White, 2012.5.22, Winbush et al., 2012, Wong and Jones, 2012, Abruzzi et al., 2011, Casper et al., 2011, Copf et al., 2011, Jiang et al., 2011, Johnson et al., 2011, Nègre et al., 2011, Singh et al., 2011, Takashima et al., 2011, Tsurumi et al., 2011, Weake et al., 2011, Yan et al., 2011, Aerts et al., 2010, Beebe et al., 2010, Bina et al., 2010, Ekas et al., 2010, Flaherty et al., 2010, Goto et al., 2010, Kallio et al., 2010, Lin et al., 2010, Ngo et al., 2010, Reddy et al., 2010, The modENCODE Consortium, 2010, The modENCODE Consortium, 2010, Wu et al., 2010, Zeng et al., 2010, Almudi et al., 2009, Avadhanula et al., 2009, Bertet et al., 2009, Buchon et al., 2009, Casper and Van Doren, 2009, Classen et al., 2009, Fujikawa et al., 2009, Gutierrez-Aviño et al., 2009, Hartmann et al., 2009, Hilger et al., 2009, Issigonis et al., 2009, Jiang et al., 2009, Shen et al., 2009, Wang and Huang, 2009, Christensen et al., 2008.4.15, Christensen et al., 2008.4.15, Christensen et al., 2008.4.15, Dougherty et al., 2008, Ekas et al., 2008, López-Onieva et al., 2008, Ni et al., 2008, Rivas et al., 2008, Takashima et al., 2008, Talamillo et al., 2008, Yasugi et al., 2008, Avila and Erickson, 2007, Ayala-Camargo et al., 2007, Ayala et al., 2007, Baeg et al., 2007, Bastock and Strutt, 2007, Beckstead et al., 2007, Beltran et al., 2007, Bianco et al., 2007, Brawley et al., 2007, Curtis et al., 2007, Kim et al., 2007, Minidorff et al., 2007, Minidorff et al., 2007, Nurminsky, 2007, Singh et al., 2007, Stahl et al., 2007, Yasugi et al., 2007, Egli et al., 2006, Hollien and Weissman, 2006, Keller, 2006, Molnar et al., 2006, Oishi et al., 2006, Payne and Braun, 2006, Shi et al., 2006, Decotto and Spradling, 2005, Moberg et al., 2005, Sage et al., 2005, Vaccari and Bilder, 2005, Wawersik et al., 2005, Wertheim et al., 2005, Yamashita et al., 2005, Rawlings et al., 2004, Wang et al., 2004, Kimbrell and Beutler, 2001)
    dSTAT92E/marelle
    l(3)j6C8
    stat92E
    (Gultekin and Steller, 2019, Saadin and Starz-Gaiano, 2018, Katheder et al., 2017, Recasens-Alvarez et al., 2017, Terriente-Félix et al., 2017, Ren et al., 2015, Bausek and Zeidler, 2014, Jones and Srivastava, 2014, Maimon et al., 2014, Thomas and Strutt, 2014, Huang et al., 2013, Silver-Morse and Li, 2013, Sotillos et al., 2013, Wells et al., 2013, Zeidler and Bausek, 2013, Zhou and Luo, 2013, Ameres et al., 2011, Stec and Zeidler, 2011, Wang et al., 2011, Wright et al., 2011, Liu et al., 2010, Robinson et al., 2010, Singh et al., 2010, Cronin et al., 2009, Flaherty et al., 2009, Gilbert et al., 2009, Gilbert et al., 2009, González et al., 2009, Jacques et al., 2009, Liu et al., 2009, Ozdowski et al., 2009, Sheng et al., 2009, Betz et al., 2008, Copf and Preat, 2008, Rodrigues and Bach, 2008, Shi et al., 2008, Sotillos et al., 2008, Ayala et al., 2007, Bach et al., 2007, Gilbert et al., 2007, Luque and Milan, 2007, Pfleger et al., 2007, Rodrigues and Bach, 2007, Arbouzova, 2006, Brown et al., 2006, de las Heras and Casanova, 2006, Ekas et al., 2006, Karsten et al., 2006, Lovegrove et al., 2006, Morrison and Kimble, 2006, Mukherjee et al., 2006, Singh et al., 2006, Hombria et al., 2005, Mukherjee et al., 2005, Brawley and Matunis, 2004, Brawley et al., 2004, Sorrentino et al., 2004, Bach et al., 2003, Chen et al., 2003, Denef and Schupbach, 2003, Ghabrial et al., 2003, Li et al., 2003, Li et al., 2003, Ozdowski et al., 2003, Silver and Montell, 2003, Bach and Perrimon, 2002, Baksa et al., 2002, Callus and Mathey-Prevot, 2002, Chen et al., 2002, Castelli-Gair et al., 2001, Jackson, 2001, Kiger et al., 2001, Luo and Dearolf, 2001, Silver and Montell, 2001, Tulina and Matunis, 2001, Myrick and Dearolf, 2000, Williams, 2000, Zeidler et al., 2000, Eldon et al., 1999, Williams et al., 1999, Zeidler et al., 1999, Harrison et al., 1998, Mathey-Prevot and Perrimon, 1998, Hou and Perrimon, 1997)
    Name Synonyms
    Signal-transducer and activator of transcription protein
    Signal-transducer and activator of transcription protein at 92E
    signal transducer and activator of transcription
    signal transducers and activator of transcription
    Secondary FlyBase IDs
    • FBgn0010885
    • FBgn0011396
    • FBgn0015512
    Datasets (1)
    Study focus (1)
    Experimental Role
    Project
    Project Type
    Title
    • bait_protein
    Genome-wide localization of transcription factors by ChIP-chip and ChIP-Seq.
    References (765)