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Gene Dmel\Stat92E

General Information
Symbol	Dmel\Stat92E	Species	D. melanogaster
Name	Signal-transducer and activator of transcription protein at 92E	Annotation symbol	CG4257
Feature type	protein_coding_gene	FlyBase ID	FBgn0016917
Gene Model Status	Current	Stock availability	17 publicly available
Also Known As	STAT, D-STAT, mrl, dSTAT, Dstat92E
Genomic Location
Chromosome (arm)	3R	Recombination map	3-
Cytogenetic map	92F1-92F1	Sequence location	3R:16,361,405..16,378,034 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Signal-transducer and activator of transcription protein at 92E is referred to in FlyBase by the symbol Dmel\Stat92E (CG4257, FBgn0016917). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription. There is experimental evidence for 24 unique biological process terms, many of which group under: biological regulation; multicellular organismal development; system development; multicellular organism reproduction; regulation of developmental process; localization; regionalization; stem cell differentiation; gamete generation; ovarian follicle cell development. 67 alleles are reported. The phenotypes of these alleles are annotated with: organ system; multicellular structure; organ system subdivision; adult segment; portion of tissue; larval abdominal segment; spiracle; acellular anatomical structure; thoracic segment; non-connected developing system. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: EF-hand-like domain; SH2 motif; STAT transcription factor, DNA-binding; STAT transcription factor, DNA-binding, subdomain; STAT transcription factor, all-alpha; STAT transcription factor, coiled coil; STAT transcription factor, core; STAT transcription factor, protein interaction; p53-like transcription factor, DNA-binding. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 00-12 and 18-24 hour embryonic stages, during late larval stages, during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, adult female reproductive system, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult salivary gland, larval trachea, adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1635827_s_at completely aligns to an exonic region common to each of the 5 FlyBase-annotated transcript isoforms of Stat92E. Gene sequence location is 3R:16361405..16378034.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Controlled Vocabulary Terms cellular response to lipopolysaccharide RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Sequence features HFA16870 BKN20615 References Shin et al., 2011, Science 334(6056): 670--674 Minakhina et al., 2011, Dev. Biol. 352(2): 308--316 Makki et al., 2010, PLoS Biol. 8(8): e1000441
FB2011_10	References Zheng et al., 2011, Dev. Biol. 357(1): 202--210
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 92F1-92F1   Limits computationally determined from genome sequence between P{PZ}l(3)1058510585 and P{EP}SyndEP409
Experimentally Determined Cytological Location
Cytogenetic map Notes References 92E2-92E2     (Yan, 1996.1.19) 92E2-92E4   (determined by in situ hybridisation)   (Spradling et al., 1999) 92E2-92E4   (determined by in situ hybridisation)   (Perrimon et al., 1996) 92E-92E   (determined by in situ hybridisation)   (Yan et al., 1996) 92E2-92E2   (determined by in situ hybridisation)   (Yan et al., 1996) 92E2-92E4   (determined by in situ hybridisation)   (Hou et al., 1996) 92E1-92E2   92E2--4   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	3- (Yan, 1996.1.19) 3-68.9 (Yan et al., 1996)
Left of (cM)	e (Yan et al., 1996)
Right of (cM)	sr (Yan et al., 1996)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Stat92E for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	DGC clone appears problematic (LP05693): incomplete CDS.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Stat92E-RB FBtr0089484  NM_169900   3628   628 Stat92E-RC FBtr0089485  NM_169899   4041   754 Stat92E-RE FBtr0089487  NM_206520   3863   754 Stat92E-RF FBtr0089486  NM_206521   3884   761 Stat92E-RG FBtr0100457  NM_001014643   3649   635
Additional Transcript Data & Comments
Reported size (kB)	4 (northern blot) (Yan et al., 1996) 4.0 (northern blot) (Hou et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Stat92E-PB   FBpp0088487   71.2   628   6.20     NP_732517   AAN14351 Stat92E-PC   FBpp0088488   85.6   754   6.24     NP_732516   AAN14350 Stat92E-PE   FBpp0088978   85.6   754   6.24     NP_996242   AAF55773 Stat92E-PF   FBpp0088489   86.4   761   6.05     NP_996243   AAS65180 Stat92E-PG   FBpp0099882   72.0   635   5.98     NP_001014643   AAX52969
Additional Polypeptide Data & Comments
Reported size (kDa)	761 (aa); 86 (kD predicted) (Hou et al., 1996) 754 (aa) (Yan et al., 1996)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • STAT transcription factor, coiled coil (IPR015988) SH2 motif (IPR000980) STAT transcription factor, core (IPR001217) p53-like transcription factor, DNA-binding (IPR008967) EF-hand-like domain (IPR011992) STAT transcription factor, DNA-binding, subdomain (IPR012345) STAT transcription factor, protein interaction (IPR013799) STAT transcription factor, all-alpha (IPR013800) STAT transcription factor, DNA-binding (IPR013801)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA263566   AA390632   AA390743   AA393021   AA439338   AA441426   AA540731   AA695491   AA696489   AA696948   AA735507   AA816374   AA816499   AA817513   AA941895   AA948793   AA949735   AA950338   AA951599   AA978545   AE014297 AAF55773   AE014297 AAN14350   AE014297 AAN14351   AE014297 AAS65180   AE014297 AAX52969   AI257359   AI258551   AI259128   AI404612   AI514989   AI515398   AI542017   AQ026216   AQ034126   AQ073971   AW944051   AY094839 AAM11192   BE975122   BG638348   BI163204   BI165496   BI166015   BI166199   BI166685   BI168365   BI168579   BI169038   BI170093   BI171421   BI171431   BI172804   BI212569   BI213216   BI229392   BI229463   BI234381   BI236272   BI241647   BI357069   BI362439   BI362978   BI363219   BI363742   BI366123   BI375095   BI375635   BI376038   BI482472   BI483299   BI486205   BI577995   BI579996   BI580055   BI580148   BT021314 AAX33462   BT120090   CK658325   CL844324   CL943616   CO178103   CO178179   CO178647   CO186792   CO187559   CO190526   CO190851   CO191041   CO192431   CO196491   CO261930   CO263217   CO265034   CO265389   CO265699   CO266616   CO267942   CO268623   CO271960   CO272436   CO272494   CO272682   CO272881   CO273697   CO275738   CO276054   CO281442   CO286443   CO287268   CO287345   CO287461   CO289536   CO299487   CO300103   CO301942   CO303717   CO311003   CO316532   CO317433   CO318153   CO324226   CO326481   CO327579   CO329927   CO341702   CZ470286   CZ475115   CZ475116   CZ478330   CZ478331   CZ479598   EC058087   EC058253   EC061385   EC068311   EC069123   EC077992   EC082446   EC083393   EC084230   EC084255   EC086265   EC087781   EC090261   EC195850   EC197069   EC197926   EC206053   EC206379   EC206503   EC209378   EC210764   EC218108   EC218553   EC219591   EC219712   EC220712   EC221030   EC222624   EC222964   EC227116   EC229344   EC229460   EC230017   EC233591   EC241424   EC241913   EC242660   EC242788   EC243284   EC243532   EC248066   EC249132   EC249506   EC250734   EC255745   EV576418   EV578135   EV583277   EV584163   EV597186   GH941966   GH943625   GH946039   GH947731   GH948221   GH948377   GH948854   GH948982   GH949070   GH949484   GH949929   GH950804   GH950966   GH951904   GH951911   GH952259   GH952310   GH953603   GH955034   GH955613   GH955799   GH955906   GH956415   GH956961   GH957252   GH957762   GH959174   GH959848   GH960858   GH963111   GH964214   GH965630   GH965723   GH966339   GH967111   GH968402   GH969048   GH969889   GH970488   GH971600   GH972418   GH972564   GH974020   GH975267   GH975574   GH978714   GH978897   GH979143   GH979816   GH980755   GH981821   GH982154   GH984094   GH984406   GH984636   GH984865   U40070 AAC46984   U46688 AAB02195
UniProtKB/Swiss-Prot	Q24151
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 2   organism | ubiquitous   (Yan et al., 1996) Comment:reference states 1 hr AEL embryonic stage 3 -- 6   organism | pair rule expression pattern   (Yan et al., 1996) Comment:reference states 1-3 hr AEL embryonic stage 6   pole cell   (Yan et al., 1996) embryonic stage 8 -- 17   gonad   (Yan et al., 1996) extended germ band stage   mesoderm   (Yan et al., 1996) organism | segment polarity expression pattern   (Yan et al., 1996, Hou et al., 1996) embryonic stage 15 -- 17   embryonic/larval foregut   (Yan et al., 1996) embryonic/larval hindgut   (Yan et al., 1996) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early   organism | ubiquitous   (Hou et al., 1996) embryonic stage -- adult stage     (Yan et al., 1996, Hou et al., 1996) embryonic stage 15   embryonic/larval foregut   (Yan et al., 1996) gonad | precursor   (Yan et al., 1996) embryonic/larval hindgut   (Yan et al., 1996)
Additional Descriptive Data
	Stat92E transcripts are detected at all stages of development by northern blot. Stat92E transcripts are detected in very early embryos in a uniform pattern by in situ hybridization. At the blastoderm stage, expression is seen in seven stripes in a broad central domain as well as in clusters of cells in anterior and posterior terminal segments. At germ band extension, 14 stripes are seen, restricted to mesodermal tissue. After germ band retraction, expression is observed mainly in the foregut, the hingut and in gonadal precursor cells. (Yan et al., 1996) Stat92E transcripts are detected at all stages on northern blots. They are detected at high and uniformly distributed levels by in situ hybridization in early syncytial and cellularizing embryos. During germ band extension they are detected in a striped pattern within every segment. (Hou et al., 1996)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 9   organism | segment polarity expression pattern   (Chen et al., 2002) oogenesis stage S5 -- S7   nurse follicle cell   • nucleus (Xi et al., 2003) polar follicle cell   • nucleus (Xi et al., 2003) centripetally migrating follicle cell   • nucleus (Xi et al., 2003) border follicle cell   • nucleus (Xi et al., 2003)
Additional Descriptive Data
	The Stat92E protein accumulates in the follicle cells of the polar regions and decreases toward the main body cells in the middle of the egg chamber in a pattern complementary to mirr expression. (Xi et al., 2003)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0016917    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0016917 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 00-12 and 18-24 hour embryonic stages, during late larval stages, during early pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0016917 expression level Developmental Stage   Expression Level embryo 00-02hr    6141 embryo 02-04hr    7238 embryo 04-06hr    5010 embryo 06-08hr    5443 embryo 08-10hr    6130 embryo 10-12hr    3549 embryo 12-14hr    3931 embryo 14-16hr    3390 embryo 16-18hr    3548 embryo 18-20hr    2513 embryo 20-22hr    4579 embryo 22-24hr    4812 larva L1    2068 larva L2    2053 larva L3 12hr old    2155 larva L3 puffstage 1-2    2972 larva L3 puffstage 3-6    4437 larva L3 puffstage 7-9    5240 white prepupae new    7207 white prepupae 12hr    5219 white prepupae 24hr    4163 pupae 2d postWPP    3119 pupae 3d postWPP    2316 pupae 4d postWPP    2051 adult male 01day    3538 adult male 05day    2902 adult male 30day    2307 adult female 01day    3701 adult female 05day    5178 adult female 30day    4731 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (6141) embryo 02-04hr  (7238) embryo 04-06hr  (5010) embryo 06-08hr  (5443) embryo 08-10hr  (6130) embryo 10-12hr  (3549) embryo 12-14hr  (3931) embryo 14-16hr  (3390) embryo 16-18hr  (3548) embryo 18-20hr  (2513) embryo 20-22hr  (4579) embryo 22-24hr  (4812) larva L1  (2068) larva L2  (2053) larva L3 12hr old  (2155) larva L3 puffstage 1-2  (2972) larva L3 puffstage 3-6  (4437) larva L3 puffstage 7-9  (5240) white prepupae new  (7207) white prepupae 12hr  (5219) white prepupae 24hr  (4163) pupae 2d postWPP  (3119) pupae 3d postWPP  (2316) pupae 4d postWPP  (2051) adult male 01day  (3538) adult male 05day  (2902) adult male 30day  (2307) adult female 01day  (3701) adult female 05day  (5178) adult female 30day  (4731) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (6141) embryo 02-04hr  (7238) embryo 04-06hr  (5010) embryo 06-08hr  (5443) embryo 08-10hr  (6130) embryo 10-12hr  (3549) embryo 12-14hr  (3931) embryo 14-16hr  (3390) embryo 16-18hr  (3548) embryo 18-20hr  (2513) embryo 20-22hr  (4579) embryo 22-24hr  (4812) larva L1  (2068) larva L2  (2053) larva L3 12hr old  (2155) larva L3 puffstage 1-2  (2972) larva L3 puffstage 3-6  (4437) larva L3 puffstage 7-9  (5240) white prepupae new  (7207) white prepupae 12hr  (5219) white prepupae 24hr  (4163) pupae 2d postWPP  (3119) pupae 3d postWPP  (2316) pupae 4d postWPP  (2051) adult male 01day  (3538) adult male 05day  (2902) adult male 30day  (2307) adult female 01day  (3701) adult female 05day  (5178) adult female 30day  (4731) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6141 embryo 02-04hr    7238 embryo 04-06hr    5010 embryo 06-08hr    5443 embryo 08-10hr    6130 embryo 10-12hr    3549 embryo 12-14hr    3931 embryo 14-16hr    3390 embryo 16-18hr    3548 embryo 18-20hr    2513 embryo 20-22hr    4579 embryo 22-24hr    4812 larva L1    2068 larva L2    2053 larva L3 12hr old    2155 larva L3 puffstage 1-2    2972 larva L3 puffstage 3-6    4437 larva L3 puffstage 7-9    5240 white prepupae new    7207 white prepupae 12hr    5219 white prepupae 24hr    4163 pupae 2d postWPP    3119 pupae 3d postWPP    2316 pupae 4d postWPP    2051 adult male 01day    3538 adult male 05day    2902 adult male 30day    2307 adult female 01day    3701 adult female 05day    5178 adult female 30day    4731 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6141 embryo 02-04hr    7238 embryo 04-06hr    5010 embryo 06-08hr    5443 embryo 08-10hr    6130 embryo 10-12hr    3549 embryo 12-14hr    3931 embryo 14-16hr    3390 embryo 16-18hr    3548 embryo 18-20hr    2513 embryo 20-22hr    4579 embryo 22-24hr    4812 larva L1    2068 larva L2    2053 larva L3 12hr old    2155 larva L3 puffstage 1-2    2972 larva L3 puffstage 3-6    4437 larva L3 puffstage 7-9    5240 white prepupae new    7207 white prepupae 12hr    5219 white prepupae 24hr    4163 pupae 2d postWPP    3119 pupae 3d postWPP    2316 pupae 4d postWPP    2051 adult male 01day    3538 adult male 05day    2902 adult male 30day    2307 adult female 01day    3701 adult female 05day    5178 adult female 30day    4731 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0016917 expression level Developmental Stage   Expression Level embryo 00-02hr    6141 embryo 02-04hr    7238 embryo 04-06hr    5010 embryo 06-08hr    5443 embryo 08-10hr    6130 embryo 10-12hr    3549 embryo 12-14hr    3931 embryo 14-16hr    3390 embryo 16-18hr    3548 embryo 18-20hr    2513 embryo 20-22hr    4579 embryo 22-24hr    4812 larva L1    2068 larva L2    2053 larva L3 12hr old    2155 larva L3 puffstage 1-2    2972 larva L3 puffstage 3-6    4437 larva L3 puffstage 7-9    5240 white prepupae new    7207 white prepupae 12hr    5219 white prepupae 24hr    4163 pupae 2d postWPP    3119 pupae 3d postWPP    2316 pupae 4d postWPP    2051 adult male 01day    3538 adult male 05day    2902 adult male 30day    2307 adult female 01day    3701 adult female 05day    5178 adult female 30day    4731 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (6141) embryo 02-04hr  (7238) embryo 04-06hr  (5010) embryo 06-08hr  (5443) embryo 08-10hr  (6130) embryo 10-12hr  (3549) embryo 12-14hr  (3931) embryo 14-16hr  (3390) embryo 16-18hr  (3548) embryo 18-20hr  (2513) embryo 20-22hr  (4579) embryo 22-24hr  (4812) larva L1  (2068) larva L2  (2053) larva L3 12hr old  (2155) larva L3 puffstage 1-2  (2972) larva L3 puffstage 3-6  (4437) larva L3 puffstage 7-9  (5240) white prepupae new  (7207) white prepupae 12hr  (5219) white prepupae 24hr  (4163) pupae 2d postWPP  (3119) pupae 3d postWPP  (2316) pupae 4d postWPP  (2051) adult male 01day  (3538) adult male 05day  (2902) adult male 30day  (2307) adult female 01day  (3701) adult female 05day  (5178) adult female 30day  (4731) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (6141) embryo 02-04hr  (7238) embryo 04-06hr  (5010) embryo 06-08hr  (5443) embryo 08-10hr  (6130) embryo 10-12hr  (3549) embryo 12-14hr  (3931) embryo 14-16hr  (3390) embryo 16-18hr  (3548) embryo 18-20hr  (2513) embryo 20-22hr  (4579) embryo 22-24hr  (4812) larva L1  2068 larva L2  2053 larva L3 12hr old  2155 larva L3 puffstage 1-2  (2972) larva L3 puffstage 3-6  (4437) larva L3 puffstage 7-9  (5240) white prepupae new  (7207) white prepupae 12hr  (5219) white prepupae 24hr  (4163) pupae 2d postWPP  (3119) pupae 3d postWPP  2316 pupae 4d postWPP  2051 adult male 01day  (3538) adult male 05day  (2902) adult male 30day  2307 adult female 01day  (3701) adult female 05day  (5178) adult female 30day  (4731) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6141 embryo 02-04hr    7238 embryo 04-06hr    5010 embryo 06-08hr    5443 embryo 08-10hr    6130 embryo 10-12hr    3549 embryo 12-14hr    3931 embryo 14-16hr    3390 embryo 16-18hr    3548 embryo 18-20hr    2513 embryo 20-22hr    4579 embryo 22-24hr    4812 larva L1    2068 larva L2    2053 larva L3 12hr old    2155 larva L3 puffstage 1-2    2972 larva L3 puffstage 3-6    4437 larva L3 puffstage 7-9    5240 white prepupae new    7207 white prepupae 12hr    5219 white prepupae 24hr    4163 pupae 2d postWPP    3119 pupae 3d postWPP    2316 pupae 4d postWPP    2051 adult male 01day    3538 adult male 05day    2902 adult male 30day    2307 adult female 01day    3701 adult female 05day    5178 adult female 30day    4731 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6141 embryo 02-04hr    7238 embryo 04-06hr    5010 embryo 06-08hr    5443 embryo 08-10hr    6130 embryo 10-12hr    3549 embryo 12-14hr    3931 embryo 14-16hr    3390 embryo 16-18hr    3548 embryo 18-20hr    2513 embryo 20-22hr    4579 embryo 22-24hr    4812 larva L1    2068 larva L2    2053 larva L3 12hr old    2155 larva L3 puffstage 1-2    2972 larva L3 puffstage 3-6    4437 larva L3 puffstage 7-9    5240 white prepupae new    7207 white prepupae 12hr    5219 white prepupae 24hr    4163 pupae 2d postWPP    3119 pupae 3d postWPP    2316 pupae 4d postWPP    2051 adult male 01day    3538 adult male 05day    2902 adult male 30day    2307 adult female 01day    3701 adult female 05day    5178 adult female 30day    4731 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0016917    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0016917 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, adult female reproductive system, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult salivary gland, larval trachea, adult male accessory gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0016917 expression level Tissue   Expression Level Larval Central Nervous System    252.125 Larval Midgut    621.4 Larval Hindgut    535.1 Larval Malpighian Tubules    581.2 Larval Fat Body    2217.5 Larval Salivary Gland    511.7 Larval Trachea    345.25 Larval Carcass    518.35 Adult Head    849.7 Adult Eye    351.55 Adult Brain    444.4 Adult Thoracic-Abdominal Ganglion    272.1 Adult Crop    728.7 Adult Midgut    782.2 Adult Hindgut    678.6 Adult Malpighian Tubules    1329.3 Adult Fat Body    1964.4 Adult Salivary Gland    354.5 Adult Heart    808.475 Adult VirginFemale Spermatheca    3309.8 Adult InseminatedFemale Spermatheca    3236.8 Adult Ovary    865.2 Adult Testis    80.7 Adult Male Accessory Gland    295.6 Adult Carcass    895.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    252.125 Larval Midgut  (621.4) Larval Hindgut  535.1 Larval Malpighian Tubules  (581.2) Larval Fat Body  (2217.5) Larval Salivary Gland  511.7 Larval Trachea    345.25 Larval Carcass  518.35 Adult Head  (849.7) Adult Eye    351.55 Adult Brain    444.4 Adult Thoracic-Abdominal Ganglion    272.1 Adult Crop  (728.7) Adult Midgut  (782.2) Adult Hindgut  (678.6) Adult Malpighian Tubules  (1329.3) Adult Fat Body  (1964.4) Adult Salivary Gland    354.5 Adult Heart  (808.475) Adult VirginFemale Spermatheca  (3309.8) Adult InseminatedFemale Spermatheca  (3236.8) Adult Ovary  (865.2) Adult Testis    80.7 Adult Male Accessory Gland    295.6 Adult Carcass  (895.2) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    252.125 Larval Midgut    621.4 Larval Hindgut    535.1 Larval Malpighian Tubules    581.2 Larval Fat Body  (2217.5) Larval Salivary Gland    511.7 Larval Trachea    345.25 Larval Carcass    518.35 Adult Head    849.7 Adult Eye    351.55 Adult Brain    444.4 Adult Thoracic-Abdominal Ganglion    272.1 Adult Crop    728.7 Adult Midgut    782.2 Adult Hindgut    678.6 Adult Malpighian Tubules  (1329.3) Adult Fat Body  (1964.4) Adult Salivary Gland    354.5 Adult Heart    808.475 Adult VirginFemale Spermatheca  (3309.8) Adult InseminatedFemale Spermatheca  (3236.8) Adult Ovary    865.2 Adult Testis    80.7 Adult Male Accessory Gland    295.6 Adult Carcass    895.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    252.125 Larval Midgut    621.4 Larval Hindgut    535.1 Larval Malpighian Tubules    581.2 Larval Fat Body    2217.5 Larval Salivary Gland    511.7 Larval Trachea    345.25 Larval Carcass    518.35 Adult Head    849.7 Adult Eye    351.55 Adult Brain    444.4 Adult Thoracic-Abdominal Ganglion    272.1 Adult Crop    728.7 Adult Midgut    782.2 Adult Hindgut    678.6 Adult Malpighian Tubules    1329.3 Adult Fat Body    1964.4 Adult Salivary Gland    354.5 Adult Heart    808.475 Adult VirginFemale Spermatheca    3309.8 Adult InseminatedFemale Spermatheca    3236.8 Adult Ovary    865.2 Adult Testis    80.7 Adult Male Accessory Gland    295.6 Adult Carcass    895.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0016917 expression level Tissue   Expression Level Larval Central Nervous System    252.125 Larval Midgut    621.4 Larval Hindgut    535.1 Larval Malpighian Tubules    581.2 Larval Fat Body    2217.5 Larval Salivary Gland    511.7 Larval Trachea    345.25 Larval Carcass    518.35 Adult Head    849.7 Adult Eye    351.55 Adult Brain    444.4 Adult Thoracic-Abdominal Ganglion    272.1 Adult Crop    728.7 Adult Midgut    782.2 Adult Hindgut    678.6 Adult Malpighian Tubules    1329.3 Adult Fat Body    1964.4 Adult Salivary Gland    354.5 Adult Heart    808.475 Adult VirginFemale Spermatheca    3309.8 Adult InseminatedFemale Spermatheca    3236.8 Adult Ovary    865.2 Adult Testis    80.7 Adult Male Accessory Gland    295.6 Adult Carcass    895.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    252.125 Larval Midgut  621.4 Larval Hindgut  535.1 Larval Malpighian Tubules  581.2 Larval Fat Body  (2217.5) Larval Salivary Gland  511.7 Larval Trachea    345.25 Larval Carcass  518.35 Adult Head  (849.7) Adult Eye    351.55 Adult Brain    444.4 Adult Thoracic-Abdominal Ganglion    272.1 Adult Crop  728.7 Adult Midgut  782.2 Adult Hindgut  678.6 Adult Malpighian Tubules  (1329.3) Adult Fat Body  (1964.4) Adult Salivary Gland    354.5 Adult Heart  808.475 Adult VirginFemale Spermatheca  (3309.8) Adult InseminatedFemale Spermatheca  (3236.8) Adult Ovary  (865.2) Adult Testis    80.7 Adult Male Accessory Gland    295.6 Adult Carcass  (895.2) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    252.125 Larval Midgut    621.4 Larval Hindgut    535.1 Larval Malpighian Tubules    581.2 Larval Fat Body  (2217.5) Larval Salivary Gland    511.7 Larval Trachea    345.25 Larval Carcass    518.35 Adult Head    849.7 Adult Eye    351.55 Adult Brain    444.4 Adult Thoracic-Abdominal Ganglion    272.1 Adult Crop    728.7 Adult Midgut    782.2 Adult Hindgut    678.6 Adult Malpighian Tubules  1329.3 Adult Fat Body  (1964.4) Adult Salivary Gland    354.5 Adult Heart    808.475 Adult VirginFemale Spermatheca  (3309.8) Adult InseminatedFemale Spermatheca  (3236.8) Adult Ovary    865.2 Adult Testis    80.7 Adult Male Accessory Gland    295.6 Adult Carcass    895.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    252.125 Larval Midgut    621.4 Larval Hindgut    535.1 Larval Malpighian Tubules    581.2 Larval Fat Body    2217.5 Larval Salivary Gland    511.7 Larval Trachea    345.25 Larval Carcass    518.35 Adult Head    849.7 Adult Eye    351.55 Adult Brain    444.4 Adult Thoracic-Abdominal Ganglion    272.1 Adult Crop    728.7 Adult Midgut    782.2 Adult Hindgut    678.6 Adult Malpighian Tubules    1329.3 Adult Fat Body    1964.4 Adult Salivary Gland    354.5 Adult Heart    808.475 Adult VirginFemale Spermatheca    3309.8 Adult InseminatedFemale Spermatheca    3236.8 Adult Ovary    865.2 Adult Testis    80.7 Adult Male Accessory Gland    295.6 Adult Carcass    895.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    849.7   NA  Eye    351.55   NA  Brain    444.4   252.125  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    272.1   NA  Crop    728.7   621.4  Midgut    782.2   535.1  Hindgut    678.6   581.2  Malpighian Tubules    1329.3   2217.5  Fat Body    1964.4   511.7  Salivary Gland    354.5   NA  Heart    808.475   345.25  Trachea    NA   NA  VirginFemale Spermatheca    3309.8   NA  InseminatedFemale Spermatheca    3236.8   NA  Ovary    865.2   NA  Testis    80.7   NA  Male Accessory Gland    295.6   518.35  Carcass    895.2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_05
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0016917 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4257-RD
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage, with Scer\GAL4tub.PU, Stat92E85C9 Stat92ER442A.Scer\UAS.P\T.T:Ivir\HA1 Stat92ER442K.Scer\UAS.P\T.T:Ivir\HA1 Stat92ER442P.Scer\UAS.P\T.T:Ivir\HA1 Stat92EY711F.Scer\UAS.P\T.T:Ivir\HA1 lethal | embryonic stage, with Scer\GAL4tub.PU, Stat92ER442A.Scer\UAS.P\T.T:Ivir\HA1 Stat92E85C9 lethal | embryonic stage, with Scer\GAL4tub.PU, Stat92ER442K.Scer\UAS.P\T.T:Ivir\HA1 Stat92E85C9 lethal | embryonic stage, with Scer\GAL4tub.PU, Stat92ER442P.Scer\UAS.P\T.T:Ivir\HA1 Stat92E85C9 lethal | embryonic stage, with Scer\GAL4tub.PU, Stat92EY711F.Scer\UAS.P\T.T:Ivir\HA1 Stat92E85C9 lethal | embryonic stage (with Df(3R)H-B79) Stat92E85C9 Stat92E397 Stat92E06346 Stat92Ej6C8 lethal | embryonic stage | germline clone | recessive | rescuable maternal effect Stat92E3R-105-5 Stat92E3R-180-15 lethal | embryonic stage | partially | rescuable maternal effect Stat92E06346 lethal | embryonic stage | recessive Stat92E42 Stat92E85C9 lethal | embryonic stage | recessive | rescuable maternal effect Stat92E06346 lethal | first instar larval stage, with Scer\GAL4tub.PU, Stat92E85C9 Stat92ER442A.Scer\UAS.P\T.T:Ivir\HA1 Stat92ER442K.Scer\UAS.P\T.T:Ivir\HA1 Stat92ER442P.Scer\UAS.P\T.T:Ivir\HA1 Stat92EY711F.Scer\UAS.P\T.T:Ivir\HA1 lethal | first instar larval stage, with Scer\GAL4tub.PU, Stat92ER442A.Scer\UAS.P\T.T:Ivir\HA1 Stat92E85C9 lethal | first instar larval stage, with Scer\GAL4tub.PU, Stat92ER442K.Scer\UAS.P\T.T:Ivir\HA1 Stat92E85C9 lethal | first instar larval stage, with Scer\GAL4tub.PU, Stat92ER442P.Scer\UAS.P\T.T:Ivir\HA1 Stat92E85C9 lethal | first instar larval stage, with Scer\GAL4tub.PU, Stat92EY711F.Scer\UAS.P\T.T:Ivir\HA1 Stat92E85C9 lethal | first instar larval stage (with Df(3R)H-B79) Stat92E85C9 Stat92E397 Stat92E06346 Stat92Ej6C8 lethal | first instar larval stage | recessive Stat92E85C9 lethal | heat sensitive (with Stat92EF) Stat92Ej6C8 lethal | heat sensitive (with Stat92Ej6C8) Stat92EF lethal | larval stage | recessive Stat92E06346 lethal | pupal stage | heat sensitive (with Stat92E06346) Stat92EF lethal | pupal stage | heat sensitive (with Stat92EF) Stat92E06346 lethal | pupal stage | somatic clone Stat92E85C9 lethal | recessive Stat92E42 Stat92E06346 Stat92EF Stat92Ej6C8 semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 Stat92EGD4492 viable Stat92EEY10528 Stat92EHJ Sterility Allele female sterile | heat sensitive (with Stat92E06346) Stat92EF female sterile | heat sensitive (with Stat92EF) Stat92E06346 female sterile | recessive Stat92EF fertile Stat92EEY10528 male sterile (with Stat92E06346) Stat92EF male sterile (with Stat92EF) Stat92E06346 male sterile | heat sensitive (with Stat92E06346) Stat92EF male sterile | heat sensitive (with Stat92EF) Stat92E06346 Other Phenotypes Allele hyperplasia | dominant | third instar larval stage Stat92E397 increased cell death | conditional | third instar larval stage Stat92E397 melanotic mass phenotype | somatic clone, with Scer\GAL4Act5C.PI Stat92EΔNΔC.Scer\UAS.P\T.T:Ivir\HA1 memory defective | adult stage, with Scer\GAL4238Y Stat92ENIG.4257R memory defective | adult stage | heat sensitive, with Scer\GAL4ey-OK107, Scer\GAL80ts.αTub84B Stat92ENIG.4257R memory defective | adult stage | RU486 conditional, with Scer\GAL4Mef2.247.Switch Stat92EM647H.Scer\UAS.T:Avic\GFP-EGFP Stat92ENIG.4257R Stat92EΔN.Scer\UAS mitotic cell cycle defective | maternal effect Stat92E06346 planar polarity defective | recessive | somatic clone Stat92Eunspecified stress response defective | RU486 conditional, with Scer\GAL4Act5C.Switch.PR Stat92EGD4492 visible, with Scer\GAL4ey.PH Stat92EΔNΔC.Scer\UAS.P\T.T:Ivir\HA1 visible, with Scer\GAL4ey.PU Stat92EM647H.Scer\UAS.T:Avic\GFP-EGFP Stat92EScer\UAS.T:Avic\GFP-EGFP visible, with Scer\GAL4pnr-MD237 Stat92EGD4492 visible | dominant Stat92EHJ visible | germline clone Stat92E6349 visible | somatic clone Stat92E85C9 Stat92E397 Stat92E06346 wild-type Stat92Efl.cHa wild-type | germline clone Stat92E06346 wild-type | somatic clone Stat92E06346 Phenotype manifest in Allele abdominal 4 ventral denticle belt Stat92E06346 abdominal 4 ventral denticle belt | germline clone | maternal effect Stat92E06346 abdominal 5 ventral denticle belt Stat92E06346 abdominal 5 ventral denticle belt | germline clone | maternal effect Stat92E06346 abdominal 6 ventral denticle belt Stat92E06346 abdominal 7 ventral denticle belt Stat92E06346 abdominal 8 ventral denticle belt Stat92E06346 abdominal segment 5 Stat92E06346 abdominal segment 8 Stat92E06346 adult cuticle (with Stat92E06346) Stat92EF adult cuticle (with Stat92EF) Stat92E06346 adult segment Stat92EHJ antenna | somatic clone Stat92Ej6C8 axon Stat92E06346 border follicle cell Stat92E06346 Stat92E397 Stat92E56D3 Stat92E80A7 Stat92E85C9 Stat92Eunspecified border follicle cell, with Scer\GAL4slbo.2.6 Stat92EScer\UAS.cPa border follicle cell (with Stat92E397), with Scer\GAL4[-]: Stat92EEP3391 border follicle cell (with Stat92EEP3391), with Scer\GAL4[-]: Stat92E397 border follicle cell | heat sensitive (with Stat92E06346) Stat92EF border follicle cell | heat sensitive (with Stat92EEP3391) Stat92EF border follicle cell | heat sensitive (with Stat92EEP3391), with Scer\GAL4[-]: Stat92EF border follicle cell | heat sensitive (with Stat92EF) Stat92E06346 Stat92EEP3391 border follicle cell | heat sensitive (with Stat92EF), with Scer\GAL4[-]: Stat92EEP3391 border follicle cell | somatic clone Stat92E06346 central nervous system Stat92E06346 commissure Stat92E06346 cuticle & adult external head | somatic clone Stat92E85C9 cyst cell | heat sensitive (with Stat92EF) Stat92Ej6C8 cyst cell | heat sensitive (with Stat92Ej6C8) Stat92EF cyst progenitor cell | heat sensitive (with Stat92E06346) Stat92EF cyst progenitor cell | heat sensitive (with Stat92EF) Stat92E06346 cyst progenitor cell | male | heat sensitive (with Stat92EF) Stat92Ej6C8 cyst progenitor cell | male | heat sensitive (with Stat92Ej6C8) Stat92EF cyst progenitor cell | male | somatic clone Stat92E3R-105-5 Stat92E3R-180-15 Stat92Ej6C8 denticle belt | germline clone | rescuable maternal effect Stat92E06346 dorsal appendage (with Stat92E06346) Stat92EF dorsal appendage (with Stat92EF) Stat92E06346 dorsal prothorax Stat92EF ectoderm | extended germ band stage | germline clone Stat92E06346 egg chamber Stat92Ej6C8 egg chamber (with Stat92E06346) Stat92EF egg chamber (with Stat92EF) Stat92E06346 egg chamber | somatic clone Stat92Ej6C8 embryonic/first instar larval cuticle Stat92E06346 embryonic/larval anterior spiracle (with Stat92E06346) Stat92EF embryonic/larval anterior spiracle (with Stat92EF) Stat92E06346 embryonic/larval lymph gland | third instar larval stage Stat92E397 embryonic/larval posterior spiracle Stat92E06346 embryonic/larval proventriculus Stat92E06346 embryonic/larval tracheal system | germline clone Stat92E06346 embryonic abdominal segment Stat92EHJ embryonic abdominal segment 2 | germline clone Stat92E6349 embryonic abdominal segment 3 | germline clone Stat92E6349 embryonic abdominal segment 4 Stat92E06346 Stat92EdsRNA.2 Stat92EdsRNA.3-4 embryonic abdominal segment 4 | germline clone Stat92E6349 embryonic abdominal segment 4 | non-rescuable maternal effect Stat92E06346 embryonic abdominal segment 5 Stat92E06346 Stat92EdsRNA.2 Stat92EdsRNA.3-4 embryonic abdominal segment 5 | germline clone Stat92E6349 embryonic abdominal segment 5 | maternal effect Stat92E06346 embryonic abdominal segment 5 | non-rescuable maternal effect Stat92E06346 embryonic abdominal segment 6 | germline clone Stat92E6349 embryonic abdominal segment 7 | germline clone Stat92E6349 embryonic abdominal segment 8 | germline clone Stat92E6349 embryonic abdominal segment | germline clone | maternal effect Stat92E3R-105-5 Stat92E3R-180-15 embryonic head Stat92E06346 Stat92EdsRNA.2 embryonic hindgut | germline clone Stat92E06346 embryonic mesothoracic segment | germline clone Stat92E6349 embryonic metathoracic segment | germline clone Stat92E6349 embryonic prothoracic segment | germline clone Stat92E6349 embryonic segment Stat92E06346 Stat92EHJ embryonic segment | pair rule expression pattern Stat92EHJ epidermis Stat92EHJ escort cell (with Stat92E06346) Stat92EF escort cell (with Stat92EF) Stat92E06346 escort stem cell (with Stat92E06346) Stat92EF escort stem cell (with Stat92EF) Stat92E06346 eye, with Scer\GAL4ey.PH Stat92EΔNΔC.Scer\UAS.P\T.T:Ivir\HA1 eye, with Scer\GAL4ey.PU Stat92EScer\UAS.T:Avic\GFP-EGFP Stat92EM647H.Scer\UAS.T:Avic\GFP-EGFP eye | somatic clone Stat92E06346 Stat92E397 Stat92E85C9 Stat92Ej6C8 eye disc | somatic clone Stat92E85C9 filzkorper Stat92E06346 filzkorper | germline clone | maternal effect Stat92E3R-105-5 Stat92E3R-180-15 follicle cell | somatic clone Stat92Ej6C8 germarium (with Stat92E06346) Stat92EF germarium (with Stat92EF) Stat92E06346 germarium | cell non-autonomous | somatic clone Stat92Ej6C8 germline cell | embryonic stage | male Stat92E06346 germline stem cell (with Stat92E06346) Stat92EF germline stem cell (with Stat92EF) Stat92E06346 gonad | embryonic stage | maternal effect Stat92E06346 head | somatic clone Stat92E85C9 hindgut Stat92E06346 hindgut & nucleus Stat92E06346 imaginal disc Stat92EF interfollicle cell (with Stat92E06346) Stat92EF interfollicle cell (with Stat92EF) Stat92E06346 interfollicle cell | anterior | cell autonomous Stat92Ej6C8 interfollicle cell | cell autonomous Stat92E06346 leg (with Stat92E06346) Stat92EF leg (with Stat92EF) Stat92E06346 longitudinal connective Stat92E06346 male germline stem cell | cell autonomous | germline clone Stat92E06346 Stat92E105 male germline stem cell | germline clone Stat92E06346 Stat92Ej6C8 male germline stem cell | heat sensitive (with Stat92E06346) Stat92EF male germline stem cell | heat sensitive (with Stat92EF) Stat92E06346 Stat92Ej6C8 male germline stem cell | heat sensitive (with Stat92Ej6C8) Stat92EF melanotic mass | somatic clone, with Scer\GAL4Act5C.PI Stat92EΔNΔC.Scer\UAS.P\T.T:Ivir\HA1 mesothoracic segment Stat92E06346 mesothoracic tergum, with Scer\GAL4pnr-MD237 Stat92EGD4492 mesothoracic ventral denticle belt Stat92E06346 midgut, with Scer\GAL4esg-NP5130, Scer\GAL80ts.αTub84B Stat92ENIG.cUa midgut, with Scer\GAL4how-24B, Scer\GAL80ts.αTub84B Stat92ENIG.cUa morphogenetic furrow | somatic clone Stat92E85C9 mouth hooks | germline clone Stat92E6349 nurse follicle cell | somatic clone Stat92E06346 ommatidium | somatic clone Stat92Eunspecified oocyte Stat92Ej6C8 oocyte (with Stat92E06346) Stat92EF oocyte (with Stat92EF) Stat92E06346 ovarian basement membrane (with Stat92E06346) Stat92EF ovarian basement membrane (with Stat92EF) Stat92E06346 ovarian basement membrane | cell non-autonomous | somatic clone Stat92Ej6C8 ovarian sheath cell (with Stat92E06346) Stat92EF ovarian sheath cell (with Stat92EF) Stat92E06346 ovarian sheath cell | cell non-autonomous | somatic clone Stat92Ej6C8 ovariole Stat92E06346 peripheral nervous system Stat92E06346 plasmatocyte | third instar larval stage Stat92E397 polar follicle cell Stat92Ej6C8 pole cell | maternal effect Stat92E06346 posterior spiracle primordium | germline clone Stat92E6349 presumptive embryonic/larval tracheal system Stat92E06346 segment Stat92E06346 Stat92EHJ spectrosome | cell non-autonomous | somatic clone Stat92Ej6C8 spermathecum | supernumerary (with Stat92E06346) Stat92EF spermathecum | supernumerary (with Stat92EF) Stat92E06346 spermatocyte | heat sensitive (with Stat92E06346) Stat92EF spermatocyte | heat sensitive (with Stat92EF) Stat92E06346 Stat92Ej6C8 spermatocyte | heat sensitive (with Stat92Ej6C8) Stat92EF spermatogonium | heat sensitive (with Stat92E06346) Stat92EF spermatogonium | heat sensitive (with Stat92EF) Stat92E06346 Stat92Ej6C8 spermatogonium | heat sensitive (with Stat92Ej6C8) Stat92EF telson Stat92E06346 trachea Stat92EHJ tracheal branch primordium | germline clone Stat92E6349 tracheal pit Stat92E06346 tracheal system Stat92E06346 Stat92EF trichogen cell, with Scer\GAL4pnr-MD237 Stat92EGD4492 wing | posterior compartment Stat92EHJ wing disc | conditional | third instar larval stage Stat92E397 wing disc | third instar larval stage Stat92E397 wing vein Stat92EHJ wing vein | ectopic Stat92EHJ wing vein | ectopic (with Stat92E06346) Stat92EF wing vein | ectopic (with Stat92EF) Stat92E06346
Classical Alleles ( 27 )
For All Classical Alleles Show
Allele of Stat92E Class Mutagen Stocks Known lesion Stat92E06346 loss of function allele, amorphic allele - genetic evidence P-element activity 1 Yes Stat92E5-HA-1064 1 -- Stat92E5-SZ-3304 1 -- Stat92ECB-6288-3 1 -- Stat92EDG17607 1 -- Stat92EEY10528 P-element activity 1 -- Stat92EEY14209 P-element activity 1 -- Stat92EF ethyl methanesulfonate 1 Yes Stat92EHJ hypomorphic allele - genetic evidence ethyl methanesulfonate 1 Yes Stat92E85C9 amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes Stat92E105 ethyl methanesulfonate 0 -- Stat92E397 ethyl methanesulfonate 0 Yes Stat92E3R-105-5 ethyl methanesulfonate 0 -- Stat92E3R-180-15 ethyl methanesulfonate 0 -- Stat92E42 loss of function allele Delta2-3 0 Yes Stat92E56D3 ethyl methanesulfonate 0 Yes Stat92E6349 0 -- Stat92E80A7 ethyl methanesulfonate 0 -- Stat92Ec05837 piggyBac transposase 0 -- Stat92Ed06416 P-element activity 0 -- Stat92Ee00443 piggyBac transposase 0 -- Stat92Ee01780 piggyBac transposase 0 -- Stat92EEP-33 0 Yes Stat92EEP3391 P-element activity 0 -- Stat92EEPg31485 P-element activity 0 Yes Stat92Ej6C8 P-element activity 0 -- Stat92Eunspecified 0 --
Alleles Carried on Transgenic Constructs ( 40 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Stat92E Class Mutagen Stocks Known lesion Stat92EGD4492 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Stat92EdsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 1 Yes Stat92EGL00437 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Stat92EHMS00035 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Stat92EJF01265 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Stat92EJF01266 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Stat92EKK100519 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Stat92E-TAD.MtnA.T:Zzzz\His6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Stat92EAct5C.PK in vitro construct - regulatory fusion 0 Yes Stat92EAct5C.T:BPV-1\AU1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Stat92EAct5C.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes Stat92EAct5C.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Stat92EAct5C.T:Zzzz\FLAG in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes Stat92EdsRNA.2 in vitro construct - RNAi 0 Yes Stat92EdsRNA.3-4 in vitro construct - RNAi 0 Yes Stat92Efl.cHa in vitro construct 0 Yes Stat92EHJ.Act5C in vitro construct - regulatory fusion 0 Yes Stat92Ehs.PY in vitro construct - regulatory fusion 0 Yes Stat92EM647H.Scer\UAS.T:Avic\GFP-EGFP in vitro construct - amino acid replacement 0 Yes Stat92EM647H.Y704F.Scer\UAS.T:Avic\GFP-EGFP in vitro construct - amino acid replacement 0 Yes Stat92EMtnA.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Stat92ENIG.4257R in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes Stat92ENIG.cUa 0 -- Stat92ER442A.Scer\UAS.P\T.T:Ivir\HA1 in vitro construct - amino acid replacement 0 Yes Stat92ER442K.Scer\UAS.P\T.T:Ivir\HA1 in vitro construct - amino acid replacement 0 Yes Stat92ER442P.Scer\UAS.P\T.T:Ivir\HA1 in vitro construct - amino acid replacement 0 Yes Stat92EScer\UAS.cPa in vitro construct - regulatory fusion 0 Yes Stat92EScer\UAS.cSa in vitro construct - regulatory fusion 0 Yes Stat92EScer\UAS.P\T.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Stat92EScer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Stat92ET:Ivir\HA1 in vitro construct - coding region fusion 0 Yes Stat92EY704F.Act5C.T:Zzzz\FLAG in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes Stat92EY704F.Scer\UAS.T:Avic\GFP-EGFP in vitro construct - amino acid replacement 0 Yes Stat92EY704F.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes Stat92EY711F.Scer\UAS.P\T.T:Ivir\HA1 in vitro construct - amino acid replacement 0 Yes Stat92EΔC.Scer\UAS.P\T.T:Ivir\HA1 in vitro construct - deletion 0 Yes Stat92EΔN.MtnA.T:Zzzz\His6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Stat92EΔN.Scer\UAS.P\T.T:Ivir\HA1 in vitro construct - deletion 0 Yes Stat92EΔN.Scer\UAS in vitro construct - regulatory fusion 0 Yes Stat92EΔNΔC.Scer\UAS.P\T.T:Ivir\HA1 in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)BSC516 (Christensen et al., 2008.4.15) Df(3R)BSC517 (Christensen et al., 2008.4.15) Df(3R)BSC518 (Christensen et al., 2008.4.15) Df(3R)H-B79 (Spradling et al., 1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4492} NA P{KK100519} NA P{TRiP.GL00437} NA P{TRiP.HMS00035} NA P{TRiP.JF01265} NA P{TRiP.JF01266} NA P{UASp-Stat92E.3HA} NA P{UASp-Stat92E.R442A} NA P{UASp-Stat92E.R442K} NA P{UASp-Stat92E.R442P} NA P{UASp-Stat92E.Y711F} NA P{UASp-Stat92E.ΔC} NA P{UASp-Stat92E.ΔN} NA P{UASp-Stat92E.ΔNΔC} NA P{UAS-Stat92E.EGFP.M647H.Y704F} NA P{UAS-Stat92E.EGFP.M647H} NA P{UAS-Stat92E.EGFP.Y704F} NA P{UAS-Stat92E.EGFP} NA P{UAS-Stat92E.P} NA P{UAS-Stat92E.RNAi} NA P{UAS-Stat92E.S} NA P{UAS-Stat92E.Y704F} NA P{UAS-Stat92E.ΔN} NA heat-shock construct P{heat.shock/stat+} NA characterization construct P{NIG.4257R} NA P{NIG.Stat92E.U} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Stat92EEP3391 NA P{EPg}Stat92EEPg31485 NA P{EPgy2}Stat92EEY10528 NA P{EPgy2}Stat92EEY14209 NA P{GSV1}EP-55EP-55 NA P{GSV1}GSd462b NA P{GSV1}Stat92EEP-33 NA P{XP}Stat92Ed06416 NA miscellaneous insertions P{RS3}Stat92ECB-6288-3 NA P{RS5}Stat92E5-HA-1064 NA P{RS5}Stat92E5-SZ-3304 NA P{wHy}Stat92EDG17607 NA PBac{PB}Stat92Ec05837 NA PBac{RB}Stat92Ee00443 NA PBac{RB}Stat92Ee01780 NA PBac{y+-attP-9A}VK00028 NA insertion of enhancer trap P{lacW}l(3)SH131SH131 No P{lacW}Stat92Ej6C8 No P{PZ}Stat92E06346 No
Gene Ontology: Function, Process & Cellular Component ( 45 unique terms )
Terms Based on Experimental Evidence ( 28 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with Cdk4 AND inferred from physical interaction with cdc2c (Chen et al., 2003) RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription inferred from direct assay (Kwon et al., 2000)
Biological Process
CV term Evidence References
blastoderm segmentation inferred from mutant phenotype (Luo and Dearolf, 2001) border follicle cell migration inferred from mutant phenotype (Silver and Montell, 2001, Jang et al., 2009) cellular response to lipopolysaccharide inferred from direct assay (Kwon et al., 2000) cellular response to X-ray inferred from mutant phenotype (Betz et al., 2008) defense response inferred from direct assay (Kwon et al., 2000) eye-antennal disc morphogenesis inferred from mutant phenotype (Ekas et al., 2006) germ-line stem cell maintenance inferred from mutant phenotype (Brawley and Matunis, 2004) hindgut morphogenesis inferred from mutant phenotype (Li et al., 2003, Johansen et al., 2003) larval lymph gland hemopoiesis inferred from mutant phenotype (Gao et al., 2009) long-term memory inferred from mutant phenotype (Copf et al., 2011) negative regulation of antimicrobial humoral response inferred from genetic interaction with Rel (Kim et al., 2007) inferred from mutant phenotype (Kim et al., 2007) negative regulation of Wnt receptor signaling pathway inferred from mutant phenotype (Ekas et al., 2006) nervous system development inferred from mutant phenotype (Li et al., 2003) oocyte localization involved in germarium-derived egg chamber formation inferred from mutant phenotype (Torres et al., 2003) oogenesis inferred from mutant phenotype (Baksa et al., 2002, Torres et al., 2003) open tracheal system development inferred from mutant phenotype (Li et al., 2003) ovarian follicle cell stalk formation inferred from mutant phenotype (Torres et al., 2003) positive regulation of cell proliferation inferred from mutant phenotype (Buchon et al., 2010) primary sex determination inferred from mutant phenotype (Jinks et al., 2000) regulation of JAK-STAT cascade inferred from mutant phenotype (Kallio et al., 2010) segment specification inferred from mutant phenotype (Hombria et al., 2005) somatic stem cell maintenance inferred from mutant phenotype (Singh et al., 2010) stem cell division inferred from mutant phenotype (Tulina and Matunis, 2001) stem cell maintenance inferred from mutant phenotype (Kiger et al., 2001)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Agaisse et al., 2003) nucleus inferred from direct assay (Agaisse et al., 2003, Kwon et al., 2000)
Terms Based on Predictions or Assertions ( 22 terms )
Molecular Function
CV term Evidence References
calcium ion binding inferred from electronic annotation with InterPro:IPR011992 (FlyBase Curators et al., 2004-) DNA binding inferred from sequence or structural similarity with human STAT5A AND inferred from sequence or structural similarity with human STAT6 (Hou et al., 1996) traceable author statement (Luo and Dearolf, 2001) sequence-specific DNA binding transcription factor activity traceable author statement (Castelli-Gair Hombria and Brown, 2002) signal transducer activity inferred from electronic annotation with InterPro:IPR001217, InterPro:IPR012345, InterPro:IPR013799, InterPro:IPR013800, InterPro:IPR013801, InterPro:IPR015988 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
border follicle cell migration traceable author statement (Castelli-Gair Hombria and Brown, 2002) compound eye development traceable author statement (Luo and Dearolf, 2001) defense response non-traceable author statement (Lemaitre, 2000.12.20) epithelial cell fate determination, open tracheal system traceable author statement (Ghabrial et al., 2003) germ-line stem cell division traceable author statement (Lin, 2002) hemocyte proliferation traceable author statement (Evans et al., 2003) hemopoiesis non-traceable author statement (Luo and Dearolf, 2001) humoral immune response traceable author statement (Agaisse and Perrimon, 2004) imaginal disc-derived wing morphogenesis non-traceable author statement (Luo and Dearolf, 2001) JAK-STAT cascade non-traceable author statement (Lemaitre, 2000.12.20, Swiss-Prot Project Members, 1997.2.1) traceable author statement (Castelli-Gair Hombria and Brown, 2002) lamellocyte differentiation non-traceable author statement (Agaisse and Perrimon, 2004) traceable author statement (Evans et al., 2003) oogenesis traceable author statement (Castelli-Gair Hombria and Brown, 2002) regulation of transcription, DNA-dependent inferred from electronic annotation with InterPro:IPR001217, InterPro:IPR008967, InterPro:IPR012345, InterPro:IPR013799, InterPro:IPR013800, InterPro:IPR013801, InterPro:IPR015988 (FlyBase Curators et al., 2004-) non-traceable author statement (Swiss-Prot Project Members, 1997.2.1) sex determination non-traceable author statement (Luo and Dearolf, 2001) signal transduction inferred from sequence or structural similarity with UniProtKB:P51692 (FlyBase, 1992-) somatic stem cell division traceable author statement (Lin, 2002)
Cellular Component
CV term Evidence References
cytoplasm traceable author statement (Agaisse and Perrimon, 2004) nucleus inferred from sequence or structural similarity with mouse Stat5b (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1997.2.1) traceable author statement (Agaisse and Perrimon, 2004)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Stat92E allele Gene References Stat92E06346 dome (Brown et al., 2001) hop (Hou et al., 1996, Luo et al., 1997, Remillieux-Leschelle et al., 2002, Muller et al., 2005) os (Bach et al., 2003, Muller et al., 2005) Ras85D (Li et al., 2003) Su(var)2-10 (Betz et al., 2001) Tl (Remillieux-Leschelle et al., 2002) tor (Li et al., 2002, Li and Li, 2003) Stat92EHJ hop (Yan et al., 1996, Yan et al., 1996, Luo et al., 1997) Stat92Ehs.PY Su(var)2-10 (Betz et al., 2001) Stat92Ej6C8 os (Bach et al., 2003) Stat92Eunspecified dome (Ghiglione et al., 2002) Egfr (Li and Li, 2003) hop (Zeidler et al., 1999) unspecified Csk (Read et al., 2004) hop (Silver and Montell, 2001) os (Mukherjee et al., 2006, Silver and Montell, 2001, Read et al., 2004) Rac1 (Silver, 2005) shg (Silver and Montell, 2001) slbo (Silver and Montell, 2001) Socs36E (Callus and Mathey-Prevot, 2002) TSG101 (Moberg et al., 2005) wg (Ekas et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67407 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0016917 DroID - A comprehensive database of gene and protein interactions. • FBgn0016917 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42428
Orthologs
Genome-wide drosophilid orthologs	Dana\GF23202 Dere\GG15412 Dgri\GH14167 Dmoj\GI10538 Dper\GL24086 Dpse\GA26501 Dsec\GM23187 Dsim\GD20060 Dvir\GJ24191 Dwil\GK22722 Dyak\GE25067
Curated drosophilid orthologs	Dpse\GA18061
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL009692-PA Aedes aegypti (mosquito) AGAP000099-PA Anopheles gambiae (mosquito) XP_397181.1 Apis mellifera (honey bee) XP_001946645.1 Acyrthosiphon pisum (pea aphid) 233038 Branchiostoma floridae (lancelet) BGIBMGA001739-PA Bombyx mori (silk worm) ENSBTAP00000012497 Bos taurus (bovine) CN19385 Caenorhabditis brenneri (small nematode) CBP03337 Caenorhabditis briggsae (nematode) CE35668 Caenorhabditis elegans (worm) ENSCAFP00000022915 Canis familiaris (dog) ENSCINP00000008341 Ciona intestinalis (sea squirt) JA05528 Caenorhabditis japonica (nematode) CPIJ016471 Culex pipens (mosquito) ENSCPOP00000010976 Cavia porcellus (guinea pig) RP27784 Caenorhabditis remanei (nematode) ENSCSAVP00000018918 Ciona savignyi (sedentary tunicate) 168065 Capitella spl (polychaete worm) 97641 Daphnia pulex (daphnia) ENSDARP00000059345 Danio rerio (zebra fish) ENSECAP00000006714 Equus caballus (horse) ENSGACP00000011401 Gymnopilus aculeatus (mushroom) ENSGALP00000039101 Gallus gallus (chicken) 156927 Hypsipyla robusta (cedar shoot borer) ENSP00000293328 Homo sapiens (human) ISCW005692-PA Ixodes scapularis (deer tick) 128587 Lottia gigantea (owl limpet) 38850 Monocosta brevicollis (choanoflagellate) ENSMODP00000018532 Monodelphis domestica (gray opossum) ENSMMUP00000014026 Macaca mulatta (rhesus monkey) ENSMUSP00000004143 Mus musculus (house mouse) 241935 Nematostella vectensis (starlet anemone) XP_001605495.1 Nasonia vitripennis (wasp) ENSOANP00000010371 Ornithorynchus anatinus (platypus) ENSORLP00000004950 Oryzias latipes (japanese killifish) PHUM000804-PA Pediculus humanus (human body louse) PP02322 Pristionchus pacificus (nematode) ENSPPYP00000009440 Pongo pygmaeus (orangutan) ENSPTRP00000015667 Pan troglodytes (chimpanzee) ENSRNOP00000026354 Rattus norvegicus (norway rat) XP_781834.2 Strongylocentrotus purpuratus (purple sea urchin) 53914 Trichoplax adhaerens (metazoa) XP_969477.2 Tribolium castaneum (red flour beetle) ENSTNIP00000014658 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000039531 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000001864 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11995 NV13582 LH18159 ISCW005692 FBgn0242155 FBgn0224699 FBgn0211274 FBgn0191541 FBgn0178054 JGI_V11_97641 FBgn0247875 FBgn0161676 FBgn0133302 FBgn0121643 FBgn0107663 FBgn0100196 CPIJ016471 CPIJ016469 BGIBMGA001739 ACYPI005642 ACYPI002351 GB18923 STAT2 STAT1 PHUM335200 GLEAN_13218
Stocks & Reagents
Stocks Listed in FlyBase ( 17 )
Bloomington	26899 P{UAS-Stat92E.RNAi}1, w* 31317 y1 v1; P{TRiP.JF01265}attP2 31318 y1 v1; P{TRiP.JF01266}attP2 33637 y1 v1; P{TRiP.HMS00035}attP2 21574 y1 w67c23; P{wHy}Stat92EDG17607 20181 y1 w67c23; P{EPgy2}Stat92EEY10528
Kyoto	124025 w1118; P{RS3}Stat92ECB-6288-3 125043 w1118; P{RS5}Stat92E5-HA-1064 125986 w1118; P{RS5}Stat92E5-SZ-3304
VDRC	v106980 P{KK100519}VIE-260B v43866 w1118; P{GD4492}v43866 v43867 w1118; P{GD4492}v43867/TM3
	More stocks available...
Genomic Clones ( 2 )
	BACR10P06 BACR13J19 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 214 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LP05693 RE13194
Other clones	DPiM_RE13194 MIP14837
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH24385 GM02915 GM07769 GM08763 LD01314 LD01929 LD06725 LD08982 LD09018 LD09633 LD13879 LD16355 LD20520 LD21430 LD27227 LD27431 LD28862 LD29730 LD30794 LD32216 LD46642 LD47212 LP01773 LP02469 LP15178 RE02547 RE05414 RE06033 RE06245 RE06882 RE09078 RE09376 RE09996 RE11444 RE13209 RE15481 RE17679 RE18572 RE27163 RE27244 RE30072 RE32312 RE38765 RE43419 RE46990 RE47677 RE47980 RE48675 RE51579 RE62829 RE63490 RE63959 RE65168 RE66171 RE69596 RE71782 RE74114 RE74179 RE74288 SD08040
Other clones	313 8748 9297 10858 11359 14752 31504 31848 32962 36572 42279 47475 55013 65924 100480 102882 125803 150048 161604 165606 191408 191474 214321.63 bs38h01 CK01.19C.H7 CK01.26C.F4 CK01.32A.D5 CK01.33A.F10 CK01.35C.H2 CK01.49A.H4 CK01.61C.F12 CK01.62A.E5 CK01.62D.G11 CK01.69B.C9 CK01.69C.E11 CK01.72B.E12 CK01.81B.A2 CK01.91A.F10 CK01.104D.C11 CK01.108A.E8 CK01.116A.G10 CK01.118A.H1 CK01.133A.D1 Dmel_dig_003217_0630_1132 Dmel_dig_009030_0646_2801 Dmel_dig_015621_0648_1655 Dmel_dig_015693_0613_0877 Dmel_neb_007984_0828_3654 EC33695 EK004844 EK023254 EK030346 EK048456 EK049919 EK050528 EK055311 EK055618 EK057252 EK062833 EK065408 EK065618 EK065920 EK071255 EK082052 EK087810 EK089722 EK092152 EK105321 EK107204 EK107364 EK108037 EK108637 EK111935 EK118503 EK119537 EK141318 EK142533 EK143421 EK147043 EK157162 EK175543 EK177409 EK182740 EK193023 EK223134 EK242618 EK265207 EK268025 EK270533 EK294162 EP04005 EP07562 EP13004 LD23160 RP004009742 RP004050668 RP004062583 RP004067739 RP004079644 RP004088651 RP004090799 RP004093513 RP004104099 RP004126946 RP004146427 RP004146713 RP004152285 RP004152372 RP004163330 RP004163690 RP004180026 RP004184317 RP004189896 RP004191919 RP004193359 RP004196099 RP004196247 RP004198226 RP004199629 RP004201845 RP004207033 RP004224704 RP004225294 RP004227406 RP004237832 RP004247797 RP004247992 RP004253634 RP004255985 RP004256435 RP004260699 RP004339775 RP004346936 RP004371894 RP004396068 RP004397750 RP004409868 RP004426584 RP004434351 RP004447152 RP004455251 RP004471739 RP004480630 RP004489235 RP004489403 RP004506260 RP004518240 RP004541743 RP004544442 RP004552272
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0016917 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42428
Antibody Information
	polyclonal (Shi et al., 2008, Flaherty et al., 2010, Chen et al., 2002)
Other Information
Discoverer
Etymology
	"marelle" is French for "hopscotch". (Hou et al., 1996)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Stat92E CG4257 (Gong, 1999.11)
Source for database merge of
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene. (Bartscherer et al., 2006) dsRNA made from templates generated with primers directed against this gene used in a cell-based RNAi assay to identify components or modifiers of the JAK/STAT pathway. (Mukherjee et al., 2006) Treatment of S2-derived S2-NP cells with dsRNA made from templates generated with primers directed against Stat92E results in a 12-24-fold decrease in JAK/STAT activity. (Baeg et al., 2005) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Stat92E is involved in proper differentiation and morphogenesis of multiple tissues. (Li et al., 2003) Stat92E acts downstream of the Dl/N pathway to induce the differentiation of the interfollicle (or stalk) cells. Stalks cause the polarization of adjacent anterior egg chambers by inducing shape change and preferential adhesion that positions the oocyte at the posterior. (Torres et al., 2003) Stat92E function is necessary for the proper differentiation of the polar follicle cells and the interfollicle cells. The failure of these cell to differentiate correctly leads to fused egg chambers and results in female sterility. Stat92E is part of an intracellular Jak-Stat signalling pathway and is activated by the hop Jak kinase. Partial loss of hop gene product activity gives a phenotype similar to that of Stat92E mutants, supporting the idea that the Jak-Stat pathway is involved in regulation of oogenesis. (Baksa et al., 2002) Stat92E is required autonomously in the germ cells for germline stem cell maintenance. (Kiger et al., 2001) Stat92E is required for border cell migration. (Silver and Montell, 2001) Stat92E is required in the male germline for maintenance of germ line stem cell renewal. (Tulina and Matunis, 2001) Dominant hop mutations cause hop to be a hyperactive kinase that can cause hyperactivation of the hop Stat92E pathway. (Luo et al., 1997) Stat92E acts downstream of the hop kinase and encodes a protein similar to the mammalian Stat proteins. hop may activate Stat92E to regulate transcription of target genes such as eve. Stat92E is epistatic to hop. (Hou et al., 1996) The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(whs)} P{hsFLP} chromosomes) has been used to identify the specific maternal effect phenotype for the zygotic lethal mutation. (Perrimon et al., 1996) Stat92E has been identified both by molecular and genetic strategies. A mutation in Stat92E has been identified by suppression of a hop mutant phenotype. Two binding sites for Stat92E protein have been identified in the eve stripe 3 enhancer region. (Yan et al., 1996) An allele of Stat92E was identified in a screen for second site suppressors of hopTum. Stat92E is involved in wing vein and trachea development, and segmentation in embryos and adults. (Yan et al., 1996) A unique binding activity that resembles the Stat-like activity of the mammalian system is identified in Drosophila and is encoded by pp100 and pp150 polypeptides. Vanadate/hydrogen peroxide treatment of Schneider cells induces a specific GRR binding complex whose formation is dependent upon Tyr phosphorylation. (Sweitzer et al., 1995)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_169899 NM_169900 NM_206520 NM_206521 NM_001014643 RefSeq (Proteins) • NP_732516 NP_732517 NP_996242 NP_996243 NP_001014643 DDBJ / EMBL / GenBank • AA439338 AA816374 AA948793 AAB02195 AAC46984 AAF55773 AAF55773.2 AAM11192 AAN14350 AAN14350.2 AAN14351 AAN14351.2 AAS65180 AAS65180.1 AAX33462 AAX52969 AI257359 AI258551 AI259128 AI514989 AI515398 AI542017 AQ026216 AQ034126 AQ073971 AW944051 AY094839 BI171421 BT021314 CL844324 CL943616 CZ470286 CZ475115 CZ475116 CZ478330 CZ478331 CZ479598 U40070 U46688 Entrez Gene - A searchable database of RefSeq genes. • 42428 UniProtKB/Swiss-Prot • Q24151
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • STAT transcription factor, coiled coil (IPR015988) SH2 motif (IPR000980) STAT transcription factor, core (IPR001217) p53-like transcription factor, DNA-binding (IPR008967) EF-hand-like domain (IPR011992) STAT transcription factor, DNA-binding, subdomain (IPR012345) STAT transcription factor, protein interaction (IPR013799) STAT transcription factor, all-alpha (IPR013800) STAT transcription factor, DNA-binding (IPR013801)
Linkouts
	BioGRID - A database of protein and genetic interactions • 67407 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0016917 DroID - A comprehensive database of gene and protein interactions. • FBgn0016917 DRSC - Results from RNAi screens. • FBgn0016917 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0016917 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4257-RD FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0016917 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 102403 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42428 InParanoid A subset of ortholog calls from InParanoid. • AAEL009692-PA Aedes aegypti (mosquito) AGAP000099-PA Anopheles gambiae (mosquito) XP_397181.1 Apis mellifera (honey bee) XP_001946645.1 Acyrthosiphon pisum (pea aphid) 233038 Branchiostoma floridae (lancelet) BGIBMGA001739-PA Bombyx mori (silk worm) ENSBTAP00000012497 Bos taurus (bovine) CN19385 Caenorhabditis brenneri (small nematode) CBP03337 Caenorhabditis briggsae (nematode) CE35668 Caenorhabditis elegans (worm) ENSCAFP00000022915 Canis familiaris (dog) ENSCINP00000008341 Ciona intestinalis (sea squirt) JA05528 Caenorhabditis japonica (nematode) CPIJ016471 Culex pipens (mosquito) ENSCPOP00000010976 Cavia porcellus (guinea pig) RP27784 Caenorhabditis remanei (nematode) ENSCSAVP00000018918 Ciona savignyi (sedentary tunicate) 168065 Capitella spl (polychaete worm) 97641 Daphnia pulex (daphnia) ENSDARP00000059345 Danio rerio (zebra fish) ENSECAP00000006714 Equus caballus (horse) ENSGACP00000011401 Gymnopilus aculeatus (mushroom) ENSGALP00000039101 Gallus gallus (chicken) 156927 Hypsipyla robusta (cedar shoot borer) ENSP00000293328 Homo sapiens (human) ISCW005692-PA Ixodes scapularis (deer tick) 128587 Lottia gigantea (owl limpet) 38850 Monocosta brevicollis (choanoflagellate) ENSMODP00000018532 Monodelphis domestica (gray opossum) ENSMMUP00000014026 Macaca mulatta (rhesus monkey) ENSMUSP00000004143 Mus musculus (house mouse) 241935 Nematostella vectensis (starlet anemone) XP_001605495.1 Nasonia vitripennis (wasp) ENSOANP00000010371 Ornithorynchus anatinus (platypus) ENSORLP00000004950 Oryzias latipes (japanese killifish) PHUM000804-PA Pediculus humanus (human body louse) PP02322 Pristionchus pacificus (nematode) ENSPPYP00000009440 Pongo pygmaeus (orangutan) ENSPTRP00000015667 Pan troglodytes (chimpanzee) ENSRNOP00000026354 Rattus norvegicus (norway rat) XP_781834.2 Strongylocentrotus purpuratus (purple sea urchin) 53914 Trichoplax adhaerens (metazoa) XP_969477.2 Tribolium castaneum (red flour beetle) ENSTNIP00000014658 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000039531 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000001864 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /gene/marelle.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42428 modMine - Data generated by the modENCODE project. • FBgn0016917 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11995 NV13582 LH18159 ISCW005692 FBgn0242155 FBgn0224699 FBgn0211274 FBgn0191541 FBgn0178054 JGI_V11_97641 FBgn0247875 FBgn0161676 FBgn0133302 FBgn0121643 FBgn0107663 FBgn0100196 CPIJ016471 CPIJ016469 BGIBMGA001739 ACYPI005642 ACYPI002351 GB18923 STAT2 STAT1 PHUM335200 GLEAN_13218 REDfly - A database of transcriptional regulatory elements. • FBgn0016917
Synonyms & Secondary IDs ( 41 )
Reported As
Symbol Synonym	CG4257 (Molnar et al., 2006, Keleman et al., 2009.8.5, Fujikawa et al., 2009, Ni et al., 2008, Ni et al., 2010.12.1, Ni et al., 2011.7.19) DmSTAT (Lin et al., 2004) DRODSRC (Colson and Goldstein, 1999) DSRC (Colson and Goldstein, 1999) dSTAT (Ochoa-Espinosa, 2006, Baksa et al., 1997, Delaney et al., 2006) Dstat (Schroeder et al., 2004, Ghiglione et al., 2002, Govind et al., 1999, Dearolf, 1998) D-STAT (Barolo and Posakony, 2004, Barolo and Posakony, 2002, Kwon et al., 2000, Baksa et al., 2000, Heinrich et al., 1998, Briscoe et al., 1996) D-stat (Remillieux-Leschelle et al., 2002, Yan, 1996.1.19, Sorrentino et al., 1999, Luo et al., 1997) D-Stat (Kulkarni and Arnosti, 2001, Small et al., 1996, Small et al., 1996, Park et al., 2003) DSTAT (Savant-Bhonsale et al., 1999) d-STAT (Arnosti et al., 1996) dstat (Kim et al., 2009) Dstat92E (Morey and Harrison, 1999, Devanaboyina and Harrison, 1998) Dstat 92E (Morey and Harrison, 1998) dSTAT92E (Struffi et al., 2006) dSTAT92E/marelle (Zeidler and Perrimon, 2000) D-stat/stat92E (Gilbert et al., 2002) l(3)06346 (Perrimon et al., 1996, ) l(3)j6C8   mrl (Luschnig et al., 2004, Luschnig et al., 2004, Li and Li, 2003, Li et al., 2002, Jinks et al., 2000, Li et al., 2000, Harrison and Perrimon, 1997, Hou et al., 1996, Bertet et al., 2009, Sotillos et al., 2010) mrL (Jasper et al., 2002) mrl stat92E (Fujioka et al., 1999) pSTAT (Herz et al., 2006) SD-stat (Luo et al., 1999) STAT (Ip, 2005, Agaisse et al., 2003, Hultmark and Ekengren, 2003, Beachy et al., 2004, Rorth, 2002, Sheng et al., 2005, Brown et al., 2005, Brawley et al., 2005, Seyedoleslami Esfahani et al., 2003, Mukherjee and Zeidler, 2003, Meister et al., 2000, Wawersik et al., 2004, Terry et al., 2004, Solnica-Krezel and Eaton, 2003, Lavine and Strand, 2002, Mushegian and Medzhitov, 2001, Gilbert et al., 2003, Feix et al., 2003, Castelli-Gair Hombria and Brown, 2002, Silver and Montell, 2002, Kisseleva et al., 2002, Rawlings and Harrison, 2002, Wasserman and DiNardo, 2001, Khush and Lemaitre, 2000, Perrimon and Stern, 1999, Zeidler et al., 1999, Blair, 1999, Mathey-Prevot et al., 1998, Zeidler and Perrimon, 1998, Dostert et al., 2005, Ohlstein et al., 2004, Matunis and Tulina, 2001, Sheng et al., 2006, DEVERGNE and NOSELLI, 2006, Shi et al., 2007, Castelli-Gair Hombria, 2006, Bartscherer et al., 2006, Rivas et al., 2007, Sotillos and Castelli-Gair, 2007, KrzemieÅ„ et al., 2007, Kronhamn et al., 2007, Eleftherianos et al., 2007, Kimble and Page, 2007, Yan et al., 2011, Gonsalves et al., 2011, Montell, 2006, Ayala and Bach, 2008, Issigonis et al., 2008, Wawersik et al., 2008, Han and Harrison, 2008, Yasugi et al., 2008, Copf and Preat, 2008, McConnell et al., 2008, Borghese et al., 2006, Cinnamon et al., 2008, Tsai et al., 2007, McDonald et al., 2008, Devergne et al., 2007, Buchon et al., 2009, Wang and Huang, 2009, Gutierrez-Aviño et al., 2009, Buchon et al., 2010, Pastor-Pareja et al., 2008, Zheng et al., 2011) stat (Silver et al., 2005, Yan et al., 1996, Nystul and Spradling, 2006, Krzemien et al., 2007, Gao et al., 2009, Starz-Gaiano et al., 2008, Melani et al., 2008, Sotillos et al., 2008, Jang et al., 2009, Bertet et al., 2009, Sheng et al., 2009, Leatherman and DiNardo, 2008, Leatherman and Dinardo, 2010, Reddy et al., 2010, Jiang et al., 2011) Stat (Bruckner et al., 2003, Wallenfang and DiNardo, 2004, Lopez-Schier, 2003, Lin, 2002, Peifer and McEwen, 2002, Dearolf et al., 1997, Luo and Dearolf, 1997, Yan et al., 1996, Kockel et al., 2001, Tolwinski, 2007, Okegbe and DiNardo, 2011, Wrobel et al., 2008, Lee et al., 2008, Pek et al., 2009, Shen et al., 2009, Makki et al., 2010) Stat1α-like (Sweitzer et al., 1995) stat92 (Lee et al., 2008) stat92E (Ekas et al., 2006, Callus and Mathey-Prevot, 2002, Li et al., 2003, Brawley and Matunis, 2004, Zeidler et al., 2000, Sorrentino et al., 2004, Li et al., 2003, Bach et al., 2003, Ghabrial et al., 2003, Brawley et al., 2004, Chen et al., 2003, Denef and Schupbach, 2003, Silver and Montell, 2003, Ozdowski et al., 2003, Bach and Perrimon, 2002, Chen et al., 2002, Jackson, 2001, Baksa et al., 2002, Tulina and Matunis, 2001, Kiger et al., 2001, Silver and Montell, 2001, Luo and Dearolf, 2001, Castelli-Gair et al., 2001, Williams, 2000, Myrick and Dearolf, 2000, Williams et al., 1999, Zeidler et al., 1999, Eldon et al., 1999, Harrison et al., 1998, Mathey-Prevot and Perrimon, 1998, Hou and Perrimon, 1997, Rodrigues and Bach, 2007, Gilbert et al., 2007, Ayala et al., 2007, Arbouzova, 2006, Hombria et al., 2005, Mukherjee et al., 2006, Pfleger et al., 2007, Luque and Milan, 2007, de las Heras and Casanova, 2006, Lovegrove et al., 2006, Bach et al., 2007, Singh et al., 2010, Morrison and Kimble, 2006, Copf and Preat, 2008, Rodrigues and Bach, 2008, Brown et al., 2006, Karsten et al., 2006, Shi et al., 2008, Singh et al., 2006, Sotillos et al., 2008, Liu et al., 2009, Betz et al., 2008, Flaherty et al., 2009, Cronin et al., 2009, Sheng et al., 2009, Ozdowski et al., 2009, Gilbert et al., 2009, Gilbert et al., 2009, Robinson et al., 2010, Jacques et al., 2009, Mukherjee et al., 2005, Ameres et al., 2011, Liu et al., 2010, Wright et al., 2011) Stat92E (Decotto and Spradling, 2005, Yasugi et al., 2007, Brawley et al., 2007, Ayala et al., 2007, Keller, 2006, Hollien and Weissman, 2006, Nurminsky, 2007, Egli et al., 2006, Copf et al., 2011, Yan et al., 2011, Stahl et al., 2007, Moberg et al., 2005, Payne and Braun, 2006, Ekas et al., 2008, Baeg et al., 2007, Christensen et al., 2008.4.15, Christensen et al., 2008.4.15, Christensen et al., 2008.4.15, Molnar et al., 2006, Yamashita et al., 2005, Sage et al., 2005, Minidorff et al., 2007, Ayala-Camargo et al., 2007, Minidorff et al., 2007, Wawersik et al., 2005, Bastock and Strutt, 2007, Takashima et al., 2008, Kim et al., 2007, López-Onieva et al., 2008, Yasugi et al., 2008, Avila and Erickson, 2007, Weake et al., 2011, Rawlings et al., 2004, Almudi et al., 2009, Vaccari and Bilder, 2005, Buchon et al., 2009, Rivas et al., 2008, Fujikawa et al., 2009, Hilger et al., 2009, Jiang et al., 2009, Shi et al., 2006, Kimbrell and Beutler, 2001, Bertet et al., 2009, Casper and Van Doren, 2009, Oishi et al., 2006, Wang and Huang, 2009, Issigonis et al., 2009, Classen et al., 2009, Beebe et al., 2010, Flaherty et al., 2010, Wertheim et al., 2005, Goto et al., 2010, Bina et al., 2010, Lin et al., 2010, Wang et al., 2004, Ekas et al., 2010, Curtis et al., 2007, Reddy et al., 2010, Beckstead et al., 2007, Kallio et al., 2010, Shen et al., 2009, Beltran et al., 2007, Aerts et al., 2010, Zeng et al., 2010, The modENCODE Consortium, 2010, The modENCODE Consortium, 2010, Ngo et al., 2010, Jiang et al., 2011, Casper et al., 2011) STAT92E (Baeg et al., 2005, Reynolds-Kenneally and Mlodzik, 2005, Kai et al., 2005, Agaisse and Perrimon, 2004, Starz-Gaiano and Montell, 2004, Ren et al., 2004, Mukherjee et al., 2004, Karsten et al., 2004, Arbouzova et al., 2003, Chen et al., 2003, Lemaitre, 2000.12.20, Betz et al., 2007, Sheng et al., 2007, Arbouzova et al., 2006, Tsai and Sun, 2004, Wang et al., 2006, Arbouzova and Zeidler, 2006, Assa-Kunik et al., 2007, Nallamothu et al., 2008, Shi et al., 2008, Benítez et al., 2009, Gesellchen et al., 2005, Buchon et al., 2009, Li et al., 2009, Gutierrez-Aviño et al., 2009, Sotillos et al., 2010, Silver et al., 2007) STAT 92E (Xi and Harrison, 2000) stat92e (Wang et al., 2008) stat92E (Xie et al., 2005)
Name Synonym	marelle (Manning et al., 2002, Kile et al., 2002, Melnick, 1995.11.6, Vasisht et al., 1998, Hou et al., 1996, Harrison and Perrimon, 1996, Starz-Gaiano and Montell, 2004, Li et al., 2000, Briscoe et al., 1996, Hou et al., 1996, Kimbrell and Beutler, 2001) Marelle (Keller, 2006, Park et al., 2003, Bertet et al., 2009) signal transducer and activator of transcription (Montell, 2006) Signal-transducer and activator of transcription protein   Signal-transducer and activator of transcription protein at 92E   signal transducers and activator of transcription (Gutierrez-Aviño et al., 2009)
Secondary FlyBase IDs
	FBgn0010885 FBgn0011396 FBgn0015512
References ( 402 )
Generate a list of	All references relating to this gene ( 402 )
List References by type	Research paper  ( 194 ) Supplementary material  ( 12 ) Review  ( 59 ) Erratum  ( 2 ) Personal communication to FlyBase  ( 14 ) Abstract  ( 105 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 2 ) Conference report  ( 3 ) Curated genome annotation  ( 2 ) Computer file  ( 4 ) Protein sequence record  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 35 )
	Ameres et al., 2011, RNA 17(1): 54--63 Target RNA-directed tailing and trimming purifies the sorting of endo-siRNAs between the two Drosophila Argonaute proteins. [FBrf0212657] Casper et al., 2011, Development 138(16): 3357--3366 no child left behind encodes a novel chromatin factor required for germline stem cell maintenance in males but not females. [FBrf0214565] Copf et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(19): 8059--8064 Cytokine signaling through the JAK/STAT pathway is required for long-term memory in Drosophila. [FBrf0213703] Gonsalves et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(15): 5954--5963 An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway. [FBrf0214389] Jiang et al., 2011, Cell Stem Cell 8(1): 84--95 EGFR/Ras/MAPK Signaling Mediates Adult Midgut Epithelial Homeostasis and Regeneration in Drosophila. [FBrf0212694] Minakhina et al., 2011, Dev. Biol. 352(2): 308--316 JAK/STAT and the GATA factor Pannier control hemocyte maturation and differentiation in Drosophila. [FBrf0213300] Okegbe and DiNardo, 2011, Development 138(7): 1259--1267 The endoderm specifies the mesodermal niche for the germline in Drosophila via Delta-Notch signaling. [FBrf0213233] Shin et al., 2011, Science 334(6056): 670--674 Drosophila microbiome modulates host developmental and metabolic homeostasis via insulin signaling. [FBrf0216582] Tsurumi et al., 2011, PLoS Genet. 7(5): e1002086 STAT Is an Essential Activator of the Zygotic Genome in the Early Drosophila Embryo. [FBrf0214235] Weake et al., 2011, Genes Dev. 25(14): 1499--1509 Post-transcription initiation function of the ubiquitous SAGA complex in tissue-specific gene activation. [FBrf0214372] Wright et al., 2011, Cell. Signal. 23(5): 920--927 Differential activities of the Drosophila JAK/STAT pathway ligands Upd, Upd2 and Upd3. [FBrf0213113] Yan et al., 2011, FASEB J. 25(1): 232--241 Unphosphorylated STAT and heterochromatin protect genome stability. [FBrf0212715] Zheng et al., 2011, Dev. Biol. 357(1): 202--210 magu is required for germline stem cell self-renewal through BMP signaling in the Drosophila testis. [FBrf0214645] Aerts et al., 2010, PLoS Biol. 8(7): e1000435 Robust Target Gene Discovery through Transcriptome Perturbations and Genome-Wide Enhancer Predictions in Drosophila Uncovers a Regulatory Basis for Sensory Specification. [FBrf0211419] Beebe et al., 2010, Dev. Biol. 338(1): 28--37 JAK/STAT signaling coordinates stem cell proliferation and multilineage differentiation in the Drosophila intestinal stem cell lineage. [FBrf0209772] Bina et al., 2010, EMBO Rep. 11(3): 201--207 Transcriptional targets of Drosophila JAK/STAT pathway signalling as effectors of haematopoietic tumour formation. [FBrf0210131] Buchon et al., 2010, BMC Biol. 8: 152 Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection. [FBrf0212840] Cherry and Matunis, 2010, Cell Stem Cell 6(6): 557--567 Epigenetic regulation of stem cell maintenance in the Drosophila testis via the nucleosome-remodeling factor NURF. [FBrf0211111] Ekas et al., 2010, Dev. Biol. 344(2): 621--636 Characterization of a dominant-active STAT that promotes tumorigenesis in Drosophila. [FBrf0211400] Flaherty et al., 2010, Dev. Cell 18(4): 556--568 chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. [FBrf0210682] Goto et al., 2010, J. Biol. Chem. 285(21): 15731--15738 Cooperative regulation of the induction of the novel antibacterial Listericin by peptidoglycan recognition protein LE and the JAK-STAT pathway. [FBrf0210770] Kallio et al., 2010, FASEB J. 24(11): 4467--4479 Eye transformer is a negative regulator of Drosophila JAK/STAT signaling. [FBrf0212202] Karpowicz et al., 2010, Development 137(24): 4135--4145 The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration. [FBrf0212383] Leatherman and Dinardo, 2010, Nat. Cell Biol. 12(8): 806--811 Germline self-renewal requires cyst stem cells and stat regulates niche adhesion in Drosophila testes. [FBrf0211422] Lin et al., 2010, J. Mol. Cell. Biol. 2(1): 37--49 Paracrine Unpaired Signaling through the JAK/STAT Pathway Controls Self-renewal and Lineage Differentiation of Drosophila Intestinal Stem Cells. [FBrf0209721] Liu et al., 2010, J. Cell. Biochem. 109(5): 992--999 JAK-STAT is restrained by Notch to control cell proliferation of the Drosophila intestinal stem cells. [FBrf0210433] Makki et al., 2010, PLoS Biol. 8(8): e1000441 A short receptor downregulates Jak/STAT signalling to control the Drosophila cellular immune response. [FBrf0211466] Mathur et al., 2010, Science 327(5962): 210--213 A transient niche regulates the specification of Drosophila intestinal stem cells. [FBrf0209706] Ngo et al., 2010, Dev. Biol. 346(2): 284--295 Concomitant requirement for Notch and Jak/Stat signaling during neuro-epithelial differentiation in the Drosophila optic lobe. [FBrf0211910] Reddy et al., 2010, Development 137(14): 2397--2408 Influence of fat-hippo and notch signaling on the proliferation and differentiation of Drosophila optic neuroepithelia. [FBrf0211109] Ren et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(49): 21064--21069 Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways. [FBrf0212502] Robinson et al., 2010, Curr. Biol. 20(7): 582--590 Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein expanded. [FBrf0210560] Singh et al., 2010, J. Cell. Physiol. 223(2): 500--510 Competitiveness for the niche and mutual dependence of the germline and somatic stem cells in the Drosophila testis are regulated by the JAK/STAT signaling. [FBrf0210092] Sotillos et al., 2010, Dev. Biol. 340(2): 571--582 An efficient approach to isolate STAT regulated enhancers uncovers STAT92E fundamental role in Drosophila tracheal development. [FBrf0210508] Zeng et al., 2010, J. Cell. Physiol. 224(3): 766--774 Tumor suppressors Sav/scrib and oncogene ras regulate stem-cell transformation in adult Drosophila malpighian tubules. [FBrf0211181] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...