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Gene Dmel\nompB

General Information
Symbol	Dmel\nompB	Species	D. melanogaster
Name	no mechanoreceptor potential B	Annotation symbol	CG12548
Feature type	protein_coding_gene	FlyBase ID	FBgn0016919
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	IFT88, osm-5
Genomic Location
Chromosome (arm)	2L	Recombination map	2-
Cytogenetic map	39E2-39E2	Sequence location	2L:21,578,319..21,589,355 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene no mechanoreceptor potential B is referred to in FlyBase by the symbol Dmel\nompB (CG12548, FBgn0016919). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: binding. There is experimental evidence that it is involved in the biological process: sensory perception of sound; nonmotile primary cilium assembly. 13 alleles are reported. The phenotypes of these alleles are annotated with: adult antennal nerve; leg; macrochaeta; wing; scolopidial cilium. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Tetratricopeptide TPR-1; Tetratricopeptide repeat; Tetratricopeptide repeat-containing; Tetratricopeptide-like helical. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1635983_a_at aligns to a genomic region shared by exons of 2 FlyBase-annotated genes; hence it is impossible to interpret the expression pattern and levels of nompB expression signal. See the GBrowse view of nompB to determine the overlapping gene(s). Gene sequence location is 2L:21578319..21589355.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features HFA03701 HFA03731 BKN28656
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 39E2-39E2   Limits computationally determined from genome sequence between P{PZ}l(2)05095a05095a and P{lacW}Df31k05815
Experimentally Determined Cytological Location
Cytogenetic map Notes References 39E7-39F1     (Han and Kernan, 2001)
Experimentally Determined Recombination Data
Location	2- (Kernan et al., 1994)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\nompB for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) nompB-RA FBtr0085925  NM_165385   2648   852 nompB-RC FBtr0301173  NM_078889   2612   840
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein nompB-PA   FBpp0085279   96.6   852   6.74     NP_724347   AAF57218 nompB-PC   FBpp0290395   95.2   840   6.77     NP_523613   AAF57219
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Tetratricopeptide-like helical (IPR011990) Tetratricopeptide repeat-containing (IPR013026) Tetratricopeptide repeat (IPR019734) Tetratricopeptide TPR-1 (IPR001440)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141657   AE014134 AAF57218   AE014134 AAF57219   BI638985   BT025899   CO188368   CO196610   CO265017   CO276148   CO286964   CO299909   CO302951   CO322550   CO340369   CZ469462   EL871080   EL871314   EL871431   EL871432   EW712921
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7KRS6 Q9V9R6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
distribution deduced from reporter or direct label Stage Tissue/Position (including subcellular localization) Reference   olfactory sensory organ   (Han et al., 2003) mechanosensory chaeta   (Han et al., 2003) sensillum campaniformium   (Han et al., 2003) chordotonal organ   (Han et al., 2003)
Additional Descriptive Data
	Expression of nompB was observed only in type 1, cilliated sense organs including olfactory sensilla, chordotonal organs, campaniform sensilla and mechanosensory bristles. (Han et al., 2003)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0016919    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0016919 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0016919 expression level Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    2 embryo 04-06hr    2 embryo 06-08hr    6 embryo 08-10hr    13 embryo 10-12hr    41 embryo 12-14hr    91 embryo 14-16hr    58 embryo 16-18hr    93 embryo 18-20hr    58 embryo 20-22hr    42 embryo 22-24hr    50 larva L1    33 larva L2    17 larva L3 12hr old    1 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    11 white prepupae new    12 white prepupae 12hr    28 white prepupae 24hr    41 pupae 2d postWPP    65 pupae 3d postWPP    40 pupae 4d postWPP    48 adult male 01day    316 adult male 05day    516 adult male 30day    353 adult female 01day    10 adult female 05day    7 adult female 30day    6 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    2 embryo 04-06hr    2 embryo 06-08hr    6 embryo 08-10hr    13 embryo 10-12hr    41 embryo 12-14hr    91 embryo 14-16hr    58 embryo 16-18hr    93 embryo 18-20hr    58 embryo 20-22hr    42 embryo 22-24hr    50 larva L1    33 larva L2    17 larva L3 12hr old    1 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    11 white prepupae new    12 white prepupae 12hr    28 white prepupae 24hr    41 pupae 2d postWPP    65 pupae 3d postWPP    40 pupae 4d postWPP    48 adult male 01day  (316) adult male 05day  (516) adult male 30day  (353) adult female 01day    10 adult female 05day    7 adult female 30day    6 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    2 embryo 04-06hr    2 embryo 06-08hr    6 embryo 08-10hr    13 embryo 10-12hr    41 embryo 12-14hr    91 embryo 14-16hr    58 embryo 16-18hr    93 embryo 18-20hr    58 embryo 20-22hr    42 embryo 22-24hr    50 larva L1    33 larva L2    17 larva L3 12hr old    1 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    11 white prepupae new    12 white prepupae 12hr    28 white prepupae 24hr    41 pupae 2d postWPP    65 pupae 3d postWPP    40 pupae 4d postWPP    48 adult male 01day    316 adult male 05day    516 adult male 30day    353 adult female 01day    10 adult female 05day    7 adult female 30day    6 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    2 embryo 04-06hr    2 embryo 06-08hr    6 embryo 08-10hr    13 embryo 10-12hr    41 embryo 12-14hr    91 embryo 14-16hr    58 embryo 16-18hr    93 embryo 18-20hr    58 embryo 20-22hr    42 embryo 22-24hr    50 larva L1    33 larva L2    17 larva L3 12hr old    1 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    11 white prepupae new    12 white prepupae 12hr    28 white prepupae 24hr    41 pupae 2d postWPP    65 pupae 3d postWPP    40 pupae 4d postWPP    48 adult male 01day    316 adult male 05day    516 adult male 30day    353 adult female 01day    10 adult female 05day    7 adult female 30day    6 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    2 embryo 04-06hr    2 embryo 06-08hr    6 embryo 08-10hr    13 embryo 10-12hr    41 embryo 12-14hr    91 embryo 14-16hr    58 embryo 16-18hr    93 embryo 18-20hr    58 embryo 20-22hr    42 embryo 22-24hr    50 larva L1    33 larva L2    17 larva L3 12hr old    1 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    11 white prepupae new    12 white prepupae 12hr    28 white prepupae 24hr    41 pupae 2d postWPP    65 pupae 3d postWPP    40 pupae 4d postWPP    48 adult male 01day    316 adult male 05day    516 adult male 30day    353 adult female 01day    10 adult female 05day    7 adult female 30day    6 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0016919 expression level Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    2 embryo 04-06hr    2 embryo 06-08hr    6 embryo 08-10hr    13 embryo 10-12hr    41 embryo 12-14hr    91 embryo 14-16hr    58 embryo 16-18hr    93 embryo 18-20hr    58 embryo 20-22hr    42 embryo 22-24hr    50 larva L1    33 larva L2    17 larva L3 12hr old    1 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    11 white prepupae new    12 white prepupae 12hr    28 white prepupae 24hr    41 pupae 2d postWPP    65 pupae 3d postWPP    40 pupae 4d postWPP    48 adult male 01day    316 adult male 05day    516 adult male 30day    353 adult female 01day    10 adult female 05day    7 adult female 30day    6 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    2 embryo 04-06hr    2 embryo 06-08hr    6 embryo 08-10hr    13 embryo 10-12hr    41 embryo 12-14hr    91 embryo 14-16hr    58 embryo 16-18hr    93 embryo 18-20hr    58 embryo 20-22hr    42 embryo 22-24hr    50 larva L1    33 larva L2    17 larva L3 12hr old    1 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    11 white prepupae new    12 white prepupae 12hr    28 white prepupae 24hr    41 pupae 2d postWPP    65 pupae 3d postWPP    40 pupae 4d postWPP    48 adult male 01day  (316) adult male 05day  (516) adult male 30day  (353) adult female 01day    10 adult female 05day    7 adult female 30day    6 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    2 embryo 04-06hr    2 embryo 06-08hr    6 embryo 08-10hr    13 embryo 10-12hr    41 embryo 12-14hr    91 embryo 14-16hr    58 embryo 16-18hr    93 embryo 18-20hr    58 embryo 20-22hr    42 embryo 22-24hr    50 larva L1    33 larva L2    17 larva L3 12hr old    1 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    11 white prepupae new    12 white prepupae 12hr    28 white prepupae 24hr    41 pupae 2d postWPP    65 pupae 3d postWPP    40 pupae 4d postWPP    48 adult male 01day    316 adult male 05day    516 adult male 30day    353 adult female 01day    10 adult female 05day    7 adult female 30day    6 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    2 embryo 04-06hr    2 embryo 06-08hr    6 embryo 08-10hr    13 embryo 10-12hr    41 embryo 12-14hr    91 embryo 14-16hr    58 embryo 16-18hr    93 embryo 18-20hr    58 embryo 20-22hr    42 embryo 22-24hr    50 larva L1    33 larva L2    17 larva L3 12hr old    1 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    11 white prepupae new    12 white prepupae 12hr    28 white prepupae 24hr    41 pupae 2d postWPP    65 pupae 3d postWPP    40 pupae 4d postWPP    48 adult male 01day    316 adult male 05day    516 adult male 30day    353 adult female 01day    10 adult female 05day    7 adult female 30day    6 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    2 embryo 04-06hr    2 embryo 06-08hr    6 embryo 08-10hr    13 embryo 10-12hr    41 embryo 12-14hr    91 embryo 14-16hr    58 embryo 16-18hr    93 embryo 18-20hr    58 embryo 20-22hr    42 embryo 22-24hr    50 larva L1    33 larva L2    17 larva L3 12hr old    1 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    11 white prepupae new    12 white prepupae 12hr    28 white prepupae 24hr    41 pupae 2d postWPP    65 pupae 3d postWPP    40 pupae 4d postWPP    48 adult male 01day    316 adult male 05day    516 adult male 30day    353 adult female 01day    10 adult female 05day    7 adult female 30day    6 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0016919    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0016919 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult male accessory gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0016919 expression level Tissue   Expression Level Larval Central Nervous System    5.55 Larval Midgut    5 Larval Hindgut    1.8 Larval Malpighian Tubules    6.5 Larval Fat Body no informative data Larval Salivary Gland    7.8 Larval Trachea    6.45 Larval Carcass    3.1 Adult Head    8.3 Adult Eye    5.525 Adult Brain    6.7 Adult Thoracic-Abdominal Ganglion    3.9 Adult Crop    3.5 Adult Midgut    3.3 Adult Hindgut    3.6 Adult Malpighian Tubules    4.3 Adult Fat Body    3.3 Adult Salivary Gland    6.5 Adult Heart    2.125 Adult VirginFemale Spermatheca    8.1 Adult InseminatedFemale Spermatheca    6.4 Adult Ovary    2.7 Adult Testis    64.3 Adult Male Accessory Gland    1145.3 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    5.55 Larval Midgut    5 Larval Hindgut    1.8 Larval Malpighian Tubules    6.5 Larval Fat Body no informative data Larval Salivary Gland    7.8 Larval Trachea    6.45 Larval Carcass    3.1 Adult Head    8.3 Adult Eye    5.525 Adult Brain    6.7 Adult Thoracic-Abdominal Ganglion    3.9 Adult Crop    3.5 Adult Midgut    3.3 Adult Hindgut    3.6 Adult Malpighian Tubules    4.3 Adult Fat Body    3.3 Adult Salivary Gland    6.5 Adult Heart    2.125 Adult VirginFemale Spermatheca    8.1 Adult InseminatedFemale Spermatheca    6.4 Adult Ovary    2.7 Adult Testis    64.3 Adult Male Accessory Gland  (1145.3) Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    5.55 Larval Midgut    5 Larval Hindgut    1.8 Larval Malpighian Tubules    6.5 Larval Fat Body no informative data Larval Salivary Gland    7.8 Larval Trachea    6.45 Larval Carcass    3.1 Adult Head    8.3 Adult Eye    5.525 Adult Brain    6.7 Adult Thoracic-Abdominal Ganglion    3.9 Adult Crop    3.5 Adult Midgut    3.3 Adult Hindgut    3.6 Adult Malpighian Tubules    4.3 Adult Fat Body    3.3 Adult Salivary Gland    6.5 Adult Heart    2.125 Adult VirginFemale Spermatheca    8.1 Adult InseminatedFemale Spermatheca    6.4 Adult Ovary    2.7 Adult Testis    64.3 Adult Male Accessory Gland  (1145.3) Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    5.55 Larval Midgut    5 Larval Hindgut    1.8 Larval Malpighian Tubules    6.5 Larval Fat Body no informative data Larval Salivary Gland    7.8 Larval Trachea    6.45 Larval Carcass    3.1 Adult Head    8.3 Adult Eye    5.525 Adult Brain    6.7 Adult Thoracic-Abdominal Ganglion    3.9 Adult Crop    3.5 Adult Midgut    3.3 Adult Hindgut    3.6 Adult Malpighian Tubules    4.3 Adult Fat Body    3.3 Adult Salivary Gland    6.5 Adult Heart    2.125 Adult VirginFemale Spermatheca    8.1 Adult InseminatedFemale Spermatheca    6.4 Adult Ovary    2.7 Adult Testis    64.3 Adult Male Accessory Gland    1145.3 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0016919 expression level Tissue   Expression Level Larval Central Nervous System    5.55 Larval Midgut    5 Larval Hindgut    1.8 Larval Malpighian Tubules    6.5 Larval Fat Body no informative data Larval Salivary Gland    7.8 Larval Trachea    6.45 Larval Carcass    3.1 Adult Head    8.3 Adult Eye    5.525 Adult Brain    6.7 Adult Thoracic-Abdominal Ganglion    3.9 Adult Crop    3.5 Adult Midgut    3.3 Adult Hindgut    3.6 Adult Malpighian Tubules    4.3 Adult Fat Body    3.3 Adult Salivary Gland    6.5 Adult Heart    2.125 Adult VirginFemale Spermatheca    8.1 Adult InseminatedFemale Spermatheca    6.4 Adult Ovary    2.7 Adult Testis    64.3 Adult Male Accessory Gland    1145.3 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    5.55 Larval Midgut    5 Larval Hindgut    1.8 Larval Malpighian Tubules    6.5 Larval Fat Body no informative data Larval Salivary Gland    7.8 Larval Trachea    6.45 Larval Carcass    3.1 Adult Head    8.3 Adult Eye    5.525 Adult Brain    6.7 Adult Thoracic-Abdominal Ganglion    3.9 Adult Crop    3.5 Adult Midgut    3.3 Adult Hindgut    3.6 Adult Malpighian Tubules    4.3 Adult Fat Body    3.3 Adult Salivary Gland    6.5 Adult Heart    2.125 Adult VirginFemale Spermatheca    8.1 Adult InseminatedFemale Spermatheca    6.4 Adult Ovary    2.7 Adult Testis    64.3 Adult Male Accessory Gland  (1145.3) Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    5.55 Larval Midgut    5 Larval Hindgut    1.8 Larval Malpighian Tubules    6.5 Larval Fat Body no informative data Larval Salivary Gland    7.8 Larval Trachea    6.45 Larval Carcass    3.1 Adult Head    8.3 Adult Eye    5.525 Adult Brain    6.7 Adult Thoracic-Abdominal Ganglion    3.9 Adult Crop    3.5 Adult Midgut    3.3 Adult Hindgut    3.6 Adult Malpighian Tubules    4.3 Adult Fat Body    3.3 Adult Salivary Gland    6.5 Adult Heart    2.125 Adult VirginFemale Spermatheca    8.1 Adult InseminatedFemale Spermatheca    6.4 Adult Ovary    2.7 Adult Testis    64.3 Adult Male Accessory Gland  1145.3 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    5.55 Larval Midgut    5 Larval Hindgut    1.8 Larval Malpighian Tubules    6.5 Larval Fat Body no informative data Larval Salivary Gland    7.8 Larval Trachea    6.45 Larval Carcass    3.1 Adult Head    8.3 Adult Eye    5.525 Adult Brain    6.7 Adult Thoracic-Abdominal Ganglion    3.9 Adult Crop    3.5 Adult Midgut    3.3 Adult Hindgut    3.6 Adult Malpighian Tubules    4.3 Adult Fat Body    3.3 Adult Salivary Gland    6.5 Adult Heart    2.125 Adult VirginFemale Spermatheca    8.1 Adult InseminatedFemale Spermatheca    6.4 Adult Ovary    2.7 Adult Testis    64.3 Adult Male Accessory Gland    1145.3 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    8.3   NA  Eye    5.525   NA  Brain    6.7   5.55  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    3.9   NA  Crop    3.5   5  Midgut    3.3   1.8  Hindgut    3.6   6.5  Malpighian Tubules    4.3   no informative data  Fat Body    3.3   7.8  Salivary Gland    6.5   NA  Heart    2.125   6.45  Trachea    NA   NA  VirginFemale Spermatheca    8.1   NA  InseminatedFemale Spermatheca    6.4   NA  Ovary    2.7   NA  Testis    64.3   NA  Male Accessory Gland    1145.3   3.1  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_24
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0016919 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12548-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele semi-lethal, with Scer\GAL4elav.PLu nompBGD7755 viable, with Scer\GAL4pnr-MD237 nompBGD7755 Sterility Allele fertile, with Df(2L)03832MR1, Scer\GAL4elav-C155, nompB1 nompBΔX.Scer\UAS fertile, with Df(2L)03832MR1, Scer\GAL4elav-C155, nompBΔX.Scer\UAS nompB1 fertile, with nompB1/Df(2L)03832MR1, Scer\GAL4elav-C155 nompBΔX.Scer\UAS fertile (with Df(2L)03832MR1), with Scer\GAL4elav-C155, nompBΔX.Scer\UAS nompB1 Other Phenotypes Allele auditory perception defective | recessive nompB1 nompB2 nompB3 behavior defective | recessive nompB1 nompB2 nompB3 flight defective, with Scer\GAL4elav.PLu nompBGD7755 locomotor behavior defective | recessive nompB1 nompB2 nompB3 uncoordinated | recessive nompB1 nompB2 nompB3 Phenotype manifest in Allele adult antennal nerve nompB1 nompB2 nompB3 cilium & olfactory neuron & antennal segment 3 nompBunspecified leg nompB1 nompB2 nompB3 macrochaeta nompB1 nompB2 nompB3 scolopidial cilium nompBunspecified wing nompB1 nompB2 nompB3 wing, with Scer\GAL4elav.PLu nompBGD7755
Classical Alleles ( 6 )
For All Classical Alleles Show
Allele of nompB Class Mutagen Stocks Known lesion nompBc04718 piggyBac transposase 1 -- nompBMI01901 1 -- nompB1 0 Yes nompB2 0 Yes nompB3 0 Yes nompBunspecified 0 --
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of nompB Class Mutagen Stocks Known lesion nompBGD7755 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes nompBJF03080 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes nompBKK108656 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes nompB+tHa in vitro construct - genomic fragment 0 Yes nompBScer\UAS.cHa in vitro construct - regulatory fusion 0 Yes nompBT:Avic\GFP-EGFP in vitro construct - coding region fusion 0 Yes nompBΔX.Scer\UAS in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)03832MR1 (Han et al., 2003) Df(2L)Exel7081 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7755} NA P{KK108656} NA P{TRiP.JF03080} NA P{UAS-nompB.H} NA P{UAS-nompB.ΔX} NA characterization construct P{EGFP-nompB} NA P{nompB+} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}nompBMI01901 NA PBac{PB}nompBc04718 NA insertion of enhancer trap P{lacW}l(2)SH0456SH0456 No
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
NOT flagellum assembly inferred from mutant phenotype (Han et al., 2003) nonmotile primary cilium assembly inferred from mutant phenotype (Han et al., 2003) sensory perception of sound inferred from mutant phenotype (Eberl et al., 2000, Han et al., 2003)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
binding inferred from electronic annotation with InterPro:IPR011990 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
cilium assembly inferred from sequence model (Avidor-Reiss et al., 2004) intraflagellar transport non-traceable author statement (Han and Kernan, 2002)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions nompB allele Gene References nompBunspecified msl-2 (Han et al., 2003)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61361 DroID - A comprehensive database of gene and protein interactions. • FBgn0016919 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35414
Orthologs
Genome-wide drosophilid orthologs	Dana\GF14426 Dere\GG21485 Dgri\GH13661 Dmoj\GI17413 Dper\GL26355 Dpse\GA28827 Dsec\GM16135 Dsim\GD21636 Dvir\GJ18348 Dwil\GK18677 Dyak\GE12986
Curated drosophilid orthologs	Dpse\GA11690   Dsec\nompB (Dworkin and Jones, 2009)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL007730-PA Aedes aegypti (mosquito) AGAP006324-PA Anopheles gambiae (mosquito) XP_394520.2 Apis mellifera (honey bee) XP_001942864.1 Acyrthosiphon pisum (pea aphid) 13321 Batrachochytrium dendrobatidis (chytrid fungus) 208090 Branchiostoma floridae (lancelet) ENSBTAP00000018980 Bos taurus (bovine) CN23452 Caenorhabditis brenneri (small nematode) CBP26385 Caenorhabditis briggsae (nematode) CE28361 Caenorhabditis elegans (worm) ENSCAFP00000010791 Canis familiaris (dog) ENSCINP00000005521 Ciona intestinalis (sea squirt) JA00743 Caenorhabditis japonica (nematode) CPIJ008234 Culex pipens (mosquito) ENSCPOP00000008226 Cavia porcellus (guinea pig) 24421 Chlamidomonas reinhardtii (green alga) RP43642 Caenorhabditis remanei (nematode) ENSCSAVP00000002361 Ciona savignyi (sedentary tunicate) 226263 Capitella spl (polychaete worm) 308631 Daphnia pulex (daphnia) ENSDARP00000034047 Danio rerio (zebra fish) ENSECAP00000007981 Equus caballus (horse) ENSGACP00000001803 Gymnopilus aculeatus (mushroom) ENSGALP00000027626 Gallus gallus (chicken) GL50803_16660 Giardia lamblia (flagellated protozoan) 79910 Hypsipyla robusta (cedar shoot borer) ENSP00000323580 Homo sapiens (human) ISCW022645-PA Ixodes scapularis (deer tick) 131165 Lottia gigantea (owl limpet) LmjF27.1130 Leishmania major (virus) 11191 Monocosta brevicollis (choanoflagellate) ENSMODP00000010190 Monodelphis domestica (gray opossum) ENSMMUP00000036508 Macaca mulatta (rhesus monkey) ENSMUSP00000113768 Mus musculus (house mouse) 40068 Nematostella vectensis (starlet anemone) XP_001604146.1 Nasonia vitripennis (wasp) ENSOANP00000014361 Ornithorynchus anatinus (platypus) ENSORLP00000016314 Oryzias latipes (japanese killifish) PHUM002261-PA Pediculus humanus (human body louse) 139012 Physcomitrella patens (moss) ENSPPYP00000005916 Pongo pygmaeus (orangutan) ENSPTRP00000045992 Pan troglodytes (chimpanzee) ENSRNOP00000012988 Rattus norvegicus (norway rat) Smp_135480 Schistosoma mansoni (trematode parasite) XP_001179034.1 Strongylocentrotus purpuratus (purple sea urchin) 56242 Trichoplax adhaerens (metazoa) XP_975466.1 Tribolium castaneum (red flour beetle) ENSTNIP00000018747 Tetraodon nigroviridis (green spotted pufferfish) 31358 Thalassiosira pseudonana (marine diatom) ENSTRUP00000040293 Takifugu rubripes (pufferfish Takifugu) 3824.m03215 Tetrahymena thermophila (ciliate protozoa) 93865.m00211 Trichomonas vaginalis (parasitic flagellated protozoan) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB19105 NV16311 LH17457 ISCW022645 FBgn0230695 FBgn0220675 FBgn0205507 FBgn0201318 FBgn0193060 FBgn0171051 FBgn0250186 JGI_V11_308631 FBgn0163937 FBgn0140157 FBgn0121137 FBgn0113664 FBgn0091453 CPIJ008234 CPIJ008233 BGIBMGA000907 ACYPI003832 GB14156 AGAP006324 AAEL007730 PHUM424390 GLEAN_03554
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	28665 y1 v1; P{TRiP.JF03080}attP2 33149 y1 w*; Mi{MIC}nompBMI01901
Harvard	- PBac{PB}nompBc04718
VDRC	v104419 P{KK108656}VIE-260B v31964 w1118 P{GD7755}v31964 v31965 w1118; P{GD7755}v31965
Genomic Clones ( 2 )
	BACR12I17 BACR43O11 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 15 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP03331
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	SD21404
Other clones	CK02585 EK006756 EK039363 EK064428 EK119814 EK141239 EK176906 EK185229 EK188354 EP10521 IP03231 IP03431 IP03531
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0016919 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35414
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: nompB osm-5 (Laurencon, 2003.2.18)
Source for database merge of	Source for merge of: nompB CG12548 (Han and Kernan, 2001) Source for merge of: nompB CG14465 CG4137 CG15190 (FlyBase Genome Annotators, 2002-2003)
Additional comments	Annotations CG12548, CG14465, CG4137 and CG15190 merged as CG12548 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003)
Other Comments
	nompB is required for the assembly of sensory cilia but not for the extension or function of the sperm flagellum. (Han et al., 2003) Transcription is down-regulated in Rfx mutant tissues. (Laurencon et al., 2003) Bristle recordings of mutant flies show almost complete loss of mechanoreceptor potential (MRP). Mutations cause adult inviability due to severe uncoordination. (Kernan et al., 1994)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078889 NM_165385 RefSeq (Proteins) • NP_523613 NP_724347 DDBJ / EMBL / GenBank • AAF57218 AAF57218.2 AAF57219 AAF57219.2 CZ469462 Entrez Gene - A searchable database of RefSeq genes. • 35414 UniProtKB/TrEMBL • Q7KRS6 Q9V9R6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Tetratricopeptide-like helical (IPR011990) Tetratricopeptide repeat-containing (IPR013026) Tetratricopeptide repeat (IPR019734) Tetratricopeptide TPR-1 (IPR001440)
Linkouts
	BioGRID - A database of protein and genetic interactions • 61361 DroID - A comprehensive database of gene and protein interactions. • FBgn0016919 DRSC - Results from RNAi screens. • FBgn0016919 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0016919 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12548-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0016919 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35414 InParanoid A subset of ortholog calls from InParanoid. • AAEL007730-PA Aedes aegypti (mosquito) AGAP006324-PA Anopheles gambiae (mosquito) XP_394520.2 Apis mellifera (honey bee) XP_001942864.1 Acyrthosiphon pisum (pea aphid) 13321 Batrachochytrium dendrobatidis (chytrid fungus) 208090 Branchiostoma floridae (lancelet) ENSBTAP00000018980 Bos taurus (bovine) CN23452 Caenorhabditis brenneri (small nematode) CBP26385 Caenorhabditis briggsae (nematode) CE28361 Caenorhabditis elegans (worm) ENSCAFP00000010791 Canis familiaris (dog) ENSCINP00000005521 Ciona intestinalis (sea squirt) JA00743 Caenorhabditis japonica (nematode) CPIJ008234 Culex pipens (mosquito) ENSCPOP00000008226 Cavia porcellus (guinea pig) 24421 Chlamidomonas reinhardtii (green alga) RP43642 Caenorhabditis remanei (nematode) ENSCSAVP00000002361 Ciona savignyi (sedentary tunicate) 226263 Capitella spl (polychaete worm) 308631 Daphnia pulex (daphnia) ENSDARP00000034047 Danio rerio (zebra fish) ENSECAP00000007981 Equus caballus (horse) ENSGACP00000001803 Gymnopilus aculeatus (mushroom) ENSGALP00000027626 Gallus gallus (chicken) GL50803_16660 Giardia lamblia (flagellated protozoan) 79910 Hypsipyla robusta (cedar shoot borer) ENSP00000323580 Homo sapiens (human) ISCW022645-PA Ixodes scapularis (deer tick) 131165 Lottia gigantea (owl limpet) LmjF27.1130 Leishmania major (virus) 11191 Monocosta brevicollis (choanoflagellate) ENSMODP00000010190 Monodelphis domestica (gray opossum) ENSMMUP00000036508 Macaca mulatta (rhesus monkey) ENSMUSP00000113768 Mus musculus (house mouse) 40068 Nematostella vectensis (starlet anemone) XP_001604146.1 Nasonia vitripennis (wasp) ENSOANP00000014361 Ornithorynchus anatinus (platypus) ENSORLP00000016314 Oryzias latipes (japanese killifish) PHUM002261-PA Pediculus humanus (human body louse) 139012 Physcomitrella patens (moss) ENSPPYP00000005916 Pongo pygmaeus (orangutan) ENSPTRP00000045992 Pan troglodytes (chimpanzee) ENSRNOP00000012988 Rattus norvegicus (norway rat) Smp_135480 Schistosoma mansoni (trematode parasite) XP_001179034.1 Strongylocentrotus purpuratus (purple sea urchin) 56242 Trichoplax adhaerens (metazoa) XP_975466.1 Tribolium castaneum (red flour beetle) ENSTNIP00000018747 Tetraodon nigroviridis (green spotted pufferfish) 31358 Thalassiosira pseudonana (marine diatom) ENSTRUP00000040293 Takifugu rubripes (pufferfish Takifugu) 3824.m03215 Tetrahymena thermophila (ciliate protozoa) 93865.m00211 Trichomonas vaginalis (parasitic flagellated protozoan) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35414 modMine - Data generated by the modENCODE project. • FBgn0016919 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB19105 NV16311 LH17457 ISCW022645 FBgn0230695 FBgn0220675 FBgn0205507 FBgn0201318 FBgn0193060 FBgn0171051 FBgn0250186 JGI_V11_308631 FBgn0163937 FBgn0140157 FBgn0121137 FBgn0113664 FBgn0091453 CPIJ008234 CPIJ008233 BGIBMGA000907 ACYPI003832 GB14156 AGAP006324 AAEL007730 PHUM424390 GLEAN_03554
Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym	146590_s_at (Kristensen et al., 2005) CG4137   CG12548 (Avidor-Reiss et al., 2004, Han and Kernan, 2001, Keleman et al., 2009.8.5, Perkins et al., 2009) CG14465 (Whitfield, 2000.5.4, ) CG15190   IFT88 (Lee et al., 2007, Jekely, 2006, Lee et al., 2008) nomp (Kernan and Zuker, 1995) nompB (Dietzl et al., 2007, Fernández-Ayala et al., 2010) NOMPB (Lee et al., 2007, Lee et al., 2008, Lee et al., 2010) osm-5 (Laurencon et al., 2003, ) OSM-5 (Jekely, 2006) Tg737 (Jekely, 2006)
Name Synonym	no mechanoreceptor potential B (Kernan et al., 1994, Hurlbut et al., 2009, Harbison et al., 2005)
Secondary FlyBase IDs
	FBgn0032950 FBgn0032951 FBgn0032952 FBgn0032953
References ( 41 )
Generate a list of	All references relating to this gene ( 41 )
List References by type	Research paper  ( 12 ) Supplementary material  ( 4 ) Review  ( 4 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 5 ) FlyBase analysis  ( 2 ) Computer file  ( 2 ) Curated genome annotation  ( 2 ) Letter  ( 1 )
Recent research papers ( 2 )
	Fernández-Ayala et al., 2010, PLoS ONE 5(1): e8549 Gene expression in a Drosophila model of mitochondrial disease. [FBrf0209705] Lee et al., 2010, PLoS ONE 5(6): e11012 Drosophila TRPN(=NOMPC) channel localizes to the distal end of mechanosensory cilia. [FBrf0210994] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...