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Gene Dmel\smi35A

General Information
Symbol	Dmel\smi35A	Species	D. melanogaster
Name	smell impaired 35A	Annotation symbol	CG4551
Feature type	protein_coding_gene	FlyBase ID	FBgn0016930
Gene Model Status	Current	Stock availability	13 publicly available
Also Known As	dDYRK2, Dyrk2, DYRK, BG:DS01523.3
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	35A1-35A2	Sequence location	2L:14,184,478..14,234,108 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene smell impaired 35A is referred to in FlyBase by the symbol Dmel\smi35A (CG4551, FBgn0016930). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein serine/threonine kinase activity; ATP binding; transferase activity. There is experimental evidence that it is involved in the biological process: olfactory behavior; protein phosphorylation. 18 alleles are reported. No phenotypic data is available. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine-protein kinase, active site; Serine/threonine-protein kinase, catalytic domain; Serine/threonine-protein kinase-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, adult heart, adult salivary gland. Comments on Affy2 ProbeSet: ProbeSet 1625183_at completely aligns to an exonic region common to each of the 5 FlyBase-annotated transcript isoforms of smi35A. Gene sequence location is 2L:14184478..14234108.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Reis et al., 2010, PLoS Genet. 6(11): e1001206 Sequence features HFA03610 BKN28832 BKN50741 BKN50310
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 35A1-35A2   Limits computationally determined from genome sequence between P{lacW}l(2)34Fak00811&P{PZ}wb09437 and P{EP}elBEP2039&P{PZ}osprJ571
Experimentally Determined Cytological Location
Cytogenetic map Notes References 35A1-35A2   (determined by in situ hybridisation) 34F3--4 (determined by in situ hybridisation)   (Ashburner et al., 1999) 34F3-34F4   (determined by in situ hybridisation)   (Spradling et al., 1999) 35A-35A   (determined by in situ hybridisation)   (Anholt et al., 1996)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\smi35A for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	EST data support existence of additional transcripts due to variable use of mini-exons.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) smi35A-RA FBtr0089288  NM_078840   4585   722 smi35A-RB FBtr0089289  NM_205989   4659   722 smi35A-RC FBtr0089290  NM_205988   4663   722 smi35A-RD FBtr0100447  NM_001038817   4417   722 smi35A-RE FBtr0100448  NM_001038818   4590   722
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein smi35A-PA   FBpp0088344   79.6   722   9.21     NP_523564   AAF53380 smi35A-PB   FBpp0089218   79.6   722   9.21     NP_995711   AAS64705 smi35A-PC   FBpp0089219   79.6   722   9.21     NP_995710   AAS64706 smi35A-PD   FBpp0099869   79.6   722   9.21     NP_001033906   ABC65900 smi35A-PE   FBpp0099870   79.6   722   9.21     NP_001033907   ABC65901
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Serine/threonine-protein kinase-like domain (IPR017442) Protein kinase, catalytic domain (IPR000719) Serine/threonine-protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141561   AA391489   AA440852   AA541034   AA567518   AA735281   AA802212   AE014134 AAF53380   AE014134 AAS64705   AE014134 AAS64706   AE014134 ABC65900   AE014134 ABC65901   AE003409 AAF44860   AF168467 AAD47290   AI061670   AI238066   AI403817   AI405979   AQ025808   AQ025968   AQ026114   AW940898   AW942031   AX094061   AY069183 AAL39328   BI166978   BI167012   BI168092   BI216688   BI228036   BI233066   BI242541   BI365014   BI366568   BI368227   BI370535   BI371629   BI374328   BI375104   BI375143   BI484219   BI484220   BI484255   BI484315   BI484415   BI485246   BI564999   BI567282   BI577802   BI605522   BI617079   BI619389   BI620842   BI621432   BI624752   BI627702   BI628361   BI629452   BI630226   BP544868   BP544869   BP559960   BP559961   BT010088 AAQ22557   CA806197   CO183600   CO186004   CO188226   CO188882   CO189149   CO262376   CO265253   CO269216   CO269250   CO272208   CO272439   CO274063   CO275419   CO276710   CO277338   CO279995   CO282868   CO288276   CO291329   CO292196   CO293315   CO294369   CO300723   CO301690   CO303550   CO305235   CO305275   CO305999   CO306362   CO308069   CO309022   CO310181   CO311784   CO316843   CO320979   CO321911   CO324416   CO324504   CO328352   CO329801   CO332143   CO342890   EC051499   EC051507   EC052008   EC053981   EC054486   EC054973   EC055366   EC055369   EC056443   EC057129   EC059018   EC066041   EC068917   EC068918   EC074787   EC077124   EC080748   EC083186   EC083246   EC085067   EC085719   EC087819   EC196204   EC198262   EC202045   EC203701   EC203718   EC204038   EC205025   EC205215   EC205239   EC208614   EC209421   EC212574   EC212777   EC214638   EC217641   EC219332   EC226206   EC227725   EC237786   EC238803   EC239463   EC240659   EC244240   EC244672   EC245604   EC245840   EC246732   EC246996   EC249638   EC257625   EV580641   GH941338   GH942008   GH942043   GH943324   GH943978   GH944028   GH944278   GH944728   GH944947   GH945080   GH945873   GH947193   GH947241   GH947407   GH948183   GH948495   GH950063   GH953007   GH953378   GH954644   GH955793   GH958436   GH960110   GH960359   GH965440   GH965836   GH966755   GH966857   GH968627   GH968850   GH969805   GH971645   GH971757   GH972289   GH973305   GH973689   GH975186   GH979538   GH980784   GH980978   GH981506   GH981852   GH982560   GH982811   GH982820   GH984026   GH984739   GH984885   GH984892   GH984949   GH984952   GH985066   GH985086
UniProtKB/Swiss-Prot	Q9V3D5
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0016930    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0016930 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0016930 expression level Developmental Stage   Expression Level embryo 00-02hr    1323 embryo 02-04hr    2329 embryo 04-06hr    2072 embryo 06-08hr    2859 embryo 08-10hr    3765 embryo 10-12hr    3964 embryo 12-14hr    4245 embryo 14-16hr    4539 embryo 16-18hr    3474 embryo 18-20hr    1931 embryo 20-22hr    1591 embryo 22-24hr    1658 larva L1    635 larva L2    554 larva L3 12hr old    339 larva L3 puffstage 1-2    256 larva L3 puffstage 3-6    809 larva L3 puffstage 7-9    3018 white prepupae new    10123 white prepupae 12hr    5015 white prepupae 24hr    4175 pupae 2d postWPP    4394 pupae 3d postWPP    2413 pupae 4d postWPP    6698 adult male 01day    1826 adult male 05day    929 adult male 30day    841 adult female 01day    1740 adult female 05day    1122 adult female 30day    1022 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1323) embryo 02-04hr  (2329) embryo 04-06hr  (2072) embryo 06-08hr  (2859) embryo 08-10hr  (3765) embryo 10-12hr  (3964) embryo 12-14hr  (4245) embryo 14-16hr  (4539) embryo 16-18hr  (3474) embryo 18-20hr  (1931) embryo 20-22hr  (1591) embryo 22-24hr  (1658) larva L1  (635) larva L2  (554) larva L3 12hr old  (339) larva L3 puffstage 1-2  (256) larva L3 puffstage 3-6  (809) larva L3 puffstage 7-9  (3018) white prepupae new  (10123) white prepupae 12hr  (5015) white prepupae 24hr  (4175) pupae 2d postWPP  (4394) pupae 3d postWPP  (2413) pupae 4d postWPP  (6698) adult male 01day  (1826) adult male 05day  (929) adult male 30day  (841) adult female 01day  (1740) adult female 05day  (1122) adult female 30day  (1022) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1323 embryo 02-04hr  (2329) embryo 04-06hr  (2072) embryo 06-08hr  (2859) embryo 08-10hr  (3765) embryo 10-12hr  (3964) embryo 12-14hr  (4245) embryo 14-16hr  (4539) embryo 16-18hr  (3474) embryo 18-20hr  (1931) embryo 20-22hr  (1591) embryo 22-24hr  (1658) larva L1    635 larva L2    554 larva L3 12hr old    339 larva L3 puffstage 1-2    256 larva L3 puffstage 3-6    809 larva L3 puffstage 7-9  (3018) white prepupae new  (10123) white prepupae 12hr  (5015) white prepupae 24hr  (4175) pupae 2d postWPP  (4394) pupae 3d postWPP  (2413) pupae 4d postWPP  (6698) adult male 01day  (1826) adult male 05day    929 adult male 30day    841 adult female 01day  (1740) adult female 05day    1122 adult female 30day    1022 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1323 embryo 02-04hr    2329 embryo 04-06hr    2072 embryo 06-08hr    2859 embryo 08-10hr    3765 embryo 10-12hr    3964 embryo 12-14hr    4245 embryo 14-16hr    4539 embryo 16-18hr    3474 embryo 18-20hr    1931 embryo 20-22hr    1591 embryo 22-24hr    1658 larva L1    635 larva L2    554 larva L3 12hr old    339 larva L3 puffstage 1-2    256 larva L3 puffstage 3-6    809 larva L3 puffstage 7-9    3018 white prepupae new  10123 white prepupae 12hr    5015 white prepupae 24hr    4175 pupae 2d postWPP    4394 pupae 3d postWPP    2413 pupae 4d postWPP    6698 adult male 01day    1826 adult male 05day    929 adult male 30day    841 adult female 01day    1740 adult female 05day    1122 adult female 30day    1022 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1323 embryo 02-04hr    2329 embryo 04-06hr    2072 embryo 06-08hr    2859 embryo 08-10hr    3765 embryo 10-12hr    3964 embryo 12-14hr    4245 embryo 14-16hr    4539 embryo 16-18hr    3474 embryo 18-20hr    1931 embryo 20-22hr    1591 embryo 22-24hr    1658 larva L1    635 larva L2    554 larva L3 12hr old    339 larva L3 puffstage 1-2    256 larva L3 puffstage 3-6    809 larva L3 puffstage 7-9    3018 white prepupae new    10123 white prepupae 12hr    5015 white prepupae 24hr    4175 pupae 2d postWPP    4394 pupae 3d postWPP    2413 pupae 4d postWPP    6698 adult male 01day    1826 adult male 05day    929 adult male 30day    841 adult female 01day    1740 adult female 05day    1122 adult female 30day    1022 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0016930 expression level Developmental Stage   Expression Level embryo 00-02hr    1323 embryo 02-04hr    2329 embryo 04-06hr    2072 embryo 06-08hr    2859 embryo 08-10hr    3765 embryo 10-12hr    3964 embryo 12-14hr    4245 embryo 14-16hr    4539 embryo 16-18hr    3474 embryo 18-20hr    1931 embryo 20-22hr    1591 embryo 22-24hr    1658 larva L1    635 larva L2    554 larva L3 12hr old    339 larva L3 puffstage 1-2    256 larva L3 puffstage 3-6    809 larva L3 puffstage 7-9    3018 white prepupae new    10123 white prepupae 12hr    5015 white prepupae 24hr    4175 pupae 2d postWPP    4394 pupae 3d postWPP    2413 pupae 4d postWPP    6698 adult male 01day    1826 adult male 05day    929 adult male 30day    841 adult female 01day    1740 adult female 05day    1122 adult female 30day    1022 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1323) embryo 02-04hr  (2329) embryo 04-06hr  (2072) embryo 06-08hr  (2859) embryo 08-10hr  (3765) embryo 10-12hr  (3964) embryo 12-14hr  (4245) embryo 14-16hr  (4539) embryo 16-18hr  (3474) embryo 18-20hr  (1931) embryo 20-22hr  (1591) embryo 22-24hr  (1658) larva L1  (635) larva L2  (554) larva L3 12hr old  (339) larva L3 puffstage 1-2  (256) larva L3 puffstage 3-6  (809) larva L3 puffstage 7-9  (3018) white prepupae new  (10123) white prepupae 12hr  (5015) white prepupae 24hr  (4175) pupae 2d postWPP  (4394) pupae 3d postWPP  (2413) pupae 4d postWPP  (6698) adult male 01day  (1826) adult male 05day  (929) adult male 30day  (841) adult female 01day  (1740) adult female 05day  (1122) adult female 30day  (1022) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1323 embryo 02-04hr  2329 embryo 04-06hr  2072 embryo 06-08hr  (2859) embryo 08-10hr  (3765) embryo 10-12hr  (3964) embryo 12-14hr  (4245) embryo 14-16hr  (4539) embryo 16-18hr  (3474) embryo 18-20hr  1931 embryo 20-22hr  1591 embryo 22-24hr  1658 larva L1    635 larva L2    554 larva L3 12hr old    339 larva L3 puffstage 1-2    256 larva L3 puffstage 3-6    809 larva L3 puffstage 7-9  (3018) white prepupae new  (10123) white prepupae 12hr  (5015) white prepupae 24hr  (4175) pupae 2d postWPP  (4394) pupae 3d postWPP  2413 pupae 4d postWPP  (6698) adult male 01day  1826 adult male 05day    929 adult male 30day    841 adult female 01day  1740 adult female 05day    1122 adult female 30day    1022 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1323 embryo 02-04hr    2329 embryo 04-06hr    2072 embryo 06-08hr    2859 embryo 08-10hr    3765 embryo 10-12hr    3964 embryo 12-14hr    4245 embryo 14-16hr    4539 embryo 16-18hr    3474 embryo 18-20hr    1931 embryo 20-22hr    1591 embryo 22-24hr    1658 larva L1    635 larva L2    554 larva L3 12hr old    339 larva L3 puffstage 1-2    256 larva L3 puffstage 3-6    809 larva L3 puffstage 7-9    3018 white prepupae new  10123 white prepupae 12hr    5015 white prepupae 24hr    4175 pupae 2d postWPP    4394 pupae 3d postWPP    2413 pupae 4d postWPP    6698 adult male 01day    1826 adult male 05day    929 adult male 30day    841 adult female 01day    1740 adult female 05day    1122 adult female 30day    1022 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1323 embryo 02-04hr    2329 embryo 04-06hr    2072 embryo 06-08hr    2859 embryo 08-10hr    3765 embryo 10-12hr    3964 embryo 12-14hr    4245 embryo 14-16hr    4539 embryo 16-18hr    3474 embryo 18-20hr    1931 embryo 20-22hr    1591 embryo 22-24hr    1658 larva L1    635 larva L2    554 larva L3 12hr old    339 larva L3 puffstage 1-2    256 larva L3 puffstage 3-6    809 larva L3 puffstage 7-9    3018 white prepupae new    10123 white prepupae 12hr    5015 white prepupae 24hr    4175 pupae 2d postWPP    4394 pupae 3d postWPP    2413 pupae 4d postWPP    6698 adult male 01day    1826 adult male 05day    929 adult male 30day    841 adult female 01day    1740 adult female 05day    1122 adult female 30day    1022 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0016930    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0016930 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, adult heart, adult salivary gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0016930 expression level Tissue   Expression Level Larval Central Nervous System    410.925 Larval Midgut    47.5 Larval Hindgut    30.9 Larval Malpighian Tubules    12.6 Larval Fat Body    94.8 Larval Salivary Gland    17.5 Larval Trachea    79.35 Larval Carcass    96.7 Adult Head    225.7 Adult Eye    317.225 Adult Brain    437.8 Adult Thoracic-Abdominal Ganglion    457.7 Adult Crop    129 Adult Midgut    68.1 Adult Hindgut    45 Adult Malpighian Tubules    22.3 Adult Fat Body    25.5 Adult Salivary Gland    118.9 Adult Heart    109.225 Adult VirginFemale Spermatheca    39.6 Adult InseminatedFemale Spermatheca    43.3 Adult Ovary    54.8 Adult Testis    54.2 Adult Male Accessory Gland    34.9 Adult Carcass    43.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    410.925 Larval Midgut    47.5 Larval Hindgut    30.9 Larval Malpighian Tubules    12.6 Larval Fat Body    94.8 Larval Salivary Gland    17.5 Larval Trachea    79.35 Larval Carcass    96.7 Adult Head    225.7 Adult Eye    317.225 Adult Brain    437.8 Adult Thoracic-Abdominal Ganglion    457.7 Adult Crop    129 Adult Midgut    68.1 Adult Hindgut    45 Adult Malpighian Tubules    22.3 Adult Fat Body    25.5 Adult Salivary Gland    118.9 Adult Heart    109.225 Adult VirginFemale Spermatheca    39.6 Adult InseminatedFemale Spermatheca    43.3 Adult Ovary    54.8 Adult Testis    54.2 Adult Male Accessory Gland    34.9 Adult Carcass    43.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    410.925 Larval Midgut    47.5 Larval Hindgut    30.9 Larval Malpighian Tubules    12.6 Larval Fat Body    94.8 Larval Salivary Gland    17.5 Larval Trachea    79.35 Larval Carcass    96.7 Adult Head    225.7 Adult Eye    317.225 Adult Brain    437.8 Adult Thoracic-Abdominal Ganglion    457.7 Adult Crop    129 Adult Midgut    68.1 Adult Hindgut    45 Adult Malpighian Tubules    22.3 Adult Fat Body    25.5 Adult Salivary Gland    118.9 Adult Heart    109.225 Adult VirginFemale Spermatheca    39.6 Adult InseminatedFemale Spermatheca    43.3 Adult Ovary    54.8 Adult Testis    54.2 Adult Male Accessory Gland    34.9 Adult Carcass    43.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    410.925 Larval Midgut    47.5 Larval Hindgut    30.9 Larval Malpighian Tubules    12.6 Larval Fat Body    94.8 Larval Salivary Gland    17.5 Larval Trachea    79.35 Larval Carcass    96.7 Adult Head    225.7 Adult Eye    317.225 Adult Brain    437.8 Adult Thoracic-Abdominal Ganglion    457.7 Adult Crop    129 Adult Midgut    68.1 Adult Hindgut    45 Adult Malpighian Tubules    22.3 Adult Fat Body    25.5 Adult Salivary Gland    118.9 Adult Heart    109.225 Adult VirginFemale Spermatheca    39.6 Adult InseminatedFemale Spermatheca    43.3 Adult Ovary    54.8 Adult Testis    54.2 Adult Male Accessory Gland    34.9 Adult Carcass    43.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0016930 expression level Tissue   Expression Level Larval Central Nervous System    410.925 Larval Midgut    47.5 Larval Hindgut    30.9 Larval Malpighian Tubules    12.6 Larval Fat Body    94.8 Larval Salivary Gland    17.5 Larval Trachea    79.35 Larval Carcass    96.7 Adult Head    225.7 Adult Eye    317.225 Adult Brain    437.8 Adult Thoracic-Abdominal Ganglion    457.7 Adult Crop    129 Adult Midgut    68.1 Adult Hindgut    45 Adult Malpighian Tubules    22.3 Adult Fat Body    25.5 Adult Salivary Gland    118.9 Adult Heart    109.225 Adult VirginFemale Spermatheca    39.6 Adult InseminatedFemale Spermatheca    43.3 Adult Ovary    54.8 Adult Testis    54.2 Adult Male Accessory Gland    34.9 Adult Carcass    43.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    410.925 Larval Midgut    47.5 Larval Hindgut    30.9 Larval Malpighian Tubules    12.6 Larval Fat Body    94.8 Larval Salivary Gland    17.5 Larval Trachea    79.35 Larval Carcass    96.7 Adult Head    225.7 Adult Eye    317.225 Adult Brain    437.8 Adult Thoracic-Abdominal Ganglion    457.7 Adult Crop    129 Adult Midgut    68.1 Adult Hindgut    45 Adult Malpighian Tubules    22.3 Adult Fat Body    25.5 Adult Salivary Gland    118.9 Adult Heart    109.225 Adult VirginFemale Spermatheca    39.6 Adult InseminatedFemale Spermatheca    43.3 Adult Ovary    54.8 Adult Testis    54.2 Adult Male Accessory Gland    34.9 Adult Carcass    43.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    410.925 Larval Midgut    47.5 Larval Hindgut    30.9 Larval Malpighian Tubules    12.6 Larval Fat Body    94.8 Larval Salivary Gland    17.5 Larval Trachea    79.35 Larval Carcass    96.7 Adult Head    225.7 Adult Eye    317.225 Adult Brain    437.8 Adult Thoracic-Abdominal Ganglion    457.7 Adult Crop    129 Adult Midgut    68.1 Adult Hindgut    45 Adult Malpighian Tubules    22.3 Adult Fat Body    25.5 Adult Salivary Gland    118.9 Adult Heart    109.225 Adult VirginFemale Spermatheca    39.6 Adult InseminatedFemale Spermatheca    43.3 Adult Ovary    54.8 Adult Testis    54.2 Adult Male Accessory Gland    34.9 Adult Carcass    43.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    410.925 Larval Midgut    47.5 Larval Hindgut    30.9 Larval Malpighian Tubules    12.6 Larval Fat Body    94.8 Larval Salivary Gland    17.5 Larval Trachea    79.35 Larval Carcass    96.7 Adult Head    225.7 Adult Eye    317.225 Adult Brain    437.8 Adult Thoracic-Abdominal Ganglion    457.7 Adult Crop    129 Adult Midgut    68.1 Adult Hindgut    45 Adult Malpighian Tubules    22.3 Adult Fat Body    25.5 Adult Salivary Gland    118.9 Adult Heart    109.225 Adult VirginFemale Spermatheca    39.6 Adult InseminatedFemale Spermatheca    43.3 Adult Ovary    54.8 Adult Testis    54.2 Adult Male Accessory Gland    34.9 Adult Carcass    43.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    225.7   NA  Eye    317.225   NA  Brain    437.8   410.925  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    457.7   NA  Crop    129   47.5  Midgut    68.1   30.9  Hindgut    45   12.6  Malpighian Tubules    22.3   94.8  Fat Body    25.5   17.5  Salivary Gland    118.9   NA  Heart    109.225   79.35  Trachea    NA   NA  VirginFemale Spermatheca    39.6   NA  InseminatedFemale Spermatheca    43.3   NA  Ovary    54.8   NA  Testis    54.2   NA  Male Accessory Gland    34.9   96.7  Carcass    43.4 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_27
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0016930 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4551-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for smi35A Stages(s) 1-3 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable smi35Af04169 viable, with Scer\GAL4pnr-MD237 smi35AGD11347 Sterility Allele fertile smi35Af04169 Other Phenotypes Allele behavior defective | recessive smi35A1 chemosensitive behavior defective smi35Ak11509 smell perception defective smi35A1 visible | recessive smi35Ak11509 Phenotype manifest in Allele
Classical Alleles ( 15 )
For All Classical Alleles Show
Allele of smi35A Class Mutagen Stocks Known lesion smi35Af04169 piggyBac transposase 2 -- smi35A1 Delta2-3 1 Yes smi35Ac02848 1 -- smi35Ae00446 1 -- smi35Ae00552 1 -- smi35Ae00726 1 -- smi35Af08067 1 -- smi35ANP6341 1 -- smi35Ad08380 0 -- smi35Ad11292 0 -- smi35Ae04686 0 -- smi35Af00009 0 -- smi35Ak06901 P-element activity 0 Yes smi35Ak11509 P-element activity 0 Yes smi35Ak16716 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of smi35A Class Mutagen Stocks Known lesion smi35AGD11347 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes smi35AGL00313 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes smi35AKK108832 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel8032 (Ryder, 2004.4.26)
Not disrupted in	Df(2L)b84h50 (BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11347} NA P{KK108832} NA P{TRiP.GL00313} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}smi35Ak06901 No P{lacW}smi35Ak11509 No P{lacW}wbk16716 No P{lArB}smi35A1 No miscellaneous insertions PBac{PB}smi35Ac02848 NA PBac{RB}smi35Ae00446 NA PBac{RB}smi35Ae00552 NA PBac{RB}smi35Ae00726 NA PBac{RB}smi35Ae04686 NA PBac{WH}smi35Af00009 NA PBac{WH}smi35Af04169 NA PBac{WH}smi35Af08067 NA insertion of enhancer trap binary system P{GawB}smi35ANP6341 No insertion of mobile activating element P{GSV1}C891C891 NA P{XP}smi35Ad08380 NA P{XP}smi35Ad11292 NA
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from direct assay (assigned by UniProtKB) (Lochhead et al., 2003) protein serine/threonine kinase activity inferred from direct assay (assigned by UniProtKB) (Lochhead et al., 2003) NOT protein tyrosine kinase activity inferred from direct assay (assigned by UniProtKB) (Lochhead et al., 2003) transferase activity inferred from direct assay (assigned by UniProtKB) (Lochhead et al., 2003)
Biological Process
CV term Evidence References
olfactory behavior inferred from mutant phenotype (Anholt et al., 1996) protein phosphorylation inferred from direct assay (assigned by UniProtKB) (Lochhead et al., 2003)
Cellular Component
CV term Evidence References
cytosol inferred from direct assay (assigned by UniProtKB) (Lochhead et al., 2003)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
protein kinase activity non-traceable author statement (Fedorowicz et al., 1999, Morrison et al., 2000) protein serine/threonine kinase activity inferred from sequence or structural similarity (Ashburner et al., 1999, Ashburner et al., 1999)
Biological Process
CV term Evidence References
protein phosphorylation non-traceable author statement (Morrison et al., 2000)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions smi35A allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0016930 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34831
Orthologs
Genome-wide drosophilid orthologs	Dana\GF15600 Dere\GG10156 Dgri\GH10596 Dmoj\GI17385 Dper\GL21056 Dpse\GA18250 Dsec\GM14885 Dsim\GD22014 Dvir\GJ18062 Dwil\GK15100 Dyak\GE25082
Curated drosophilid orthologs	Dpse\GA18250
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL001504-PA Aedes aegypti (mosquito) AGAP008241-PA Anopheles gambiae (mosquito) XP_396369.2 Apis mellifera (honey bee) 211971 Branchiostoma floridae (lancelet) ENSBTAP00000009942 Bos taurus (bovine) CAL0003123 Candida albicans (a form of yeast) CE19878 Caenorhabditis elegans (worm) ENSCAFP00000022593 Canis familiaris (dog) Chro.50371 Cryptosporidium hominis (obligate parasite) JA04481 Caenorhabditis japonica (nematode) cgd5_250 Cryptosporidium parvum (protozoan parasite) ENSCPOP00000009160 Cavia porcellus (guinea pig) RP14186 Caenorhabditis remanei (nematode) ENSCSAVP00000005984 Ciona savignyi (sedentary tunicate) 149906 Capitella spl (polychaete worm) DDB0230102 Dictyostelium discoideum (amoeba) DEHA2C14080g Debaryomyces Hansenii (yeast) 51930 Daphnia pulex (daphnia) ENSDARP00000094915 Danio rerio (zebra fish) ENSECAP00000010385 Equus caballus (horse) XP_656048 Entamoeba histolytica (anaerobic protozoan) XP_656217 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000018183 Gymnopilus aculeatus (mushroom) GL50803_17417 Giardia lamblia (flagellated protozoan) 131581 Hypsipyla robusta (cedar shoot borer) ENSP00000010132 Homo sapiens (human) ISCW022190-PA Ixodes scapularis (deer tick) 117170 Lottia gigantea (owl limpet) LmjF35.1860 Leishmania major (virus) 32541 Monocosta brevicollis (choanoflagellate) ENSMODP00000022807 Monodelphis domestica (gray opossum) ENSMMUP00000039240 Macaca mulatta (rhesus monkey) ENSMUSP00000077606 Mus musculus (house mouse) 200667 Nematostella vectensis (starlet anemone) XP_001605197.1 Nasonia vitripennis (wasp) ENSOANP00000009442 Ornithorynchus anatinus (platypus) ENSORLP00000019828 Oryzias latipes (japanese killifish) PF14_0431 Plasmodium falciparum (protozoal parasite) PHUM001760-PA Pediculus humanus (human body louse) PP04805 Pristionchus pacificus (nematode) 147019 Physcomitrella patens (moss) ENSPPYP00000004751 Pongo pygmaeus (orangutan) 96448 Phytophthora ramorum (sudden oak death pathogen) ENSPTRP00000007788 Pan troglodytes (chimpanzee) ENSRNOP00000051169 Rattus norvegicus (norway rat) YJL141C Saccharomyces cerevisiae (budding yeast) SPAC2F7.03c Schizosaccharomyces pombe (fission yeast) XP_784683.2 Strongylocentrotus purpuratus (purple sea urchin) 33914 Trichoplax adhaerens (metazoa) TA19110 Theileria annulata (apicomplexan parasite) XP_972669.1 Tribolium castaneum (red flour beetle) Tc00.1047053510431.140 Trypanosoma cruzi (parasitic trypanosome) TP04_0880 Theileria parva (parasitic protozoan) ENSTRUP00000003716 Takifugu rubripes (pufferfish Takifugu) 3703.m00179 Tetrahymena thermophila (ciliate protozoa) 86498.m00531 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000051090 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17352 NV16659 NV13449 LH15563 LH16479 ISCW018301 FBgn0242170 FBgn0232088 FBgn0217105 FBgn0215660 FBgn0205227 FBgn0201661 FBgn0195743 FBgn0193427 FBgn0169806 FBgn0167935 JGI_V11_49628 JGI_V11_51930 FBgn0249311 FBgn0078256 FBgn0158651 FBgn0155974 FBgn0140129 FBgn0136869 FBgn0027101 FBgn0131444 FBgn0118077 FBgn0108646 FBgn0102467 FBgn0092624 CPIJ004687 CPIJ014802 BGIBMGA006111 BGIBMGA004611 GB18276 GB14600 AGAP008241 AGAP007847 AAEL001731 AAEL001504 PB25456 PHUM463810 PHUM574200 GLEAN_13573 GLEAN_14135
Stocks & Reagents
Stocks Listed in FlyBase ( 13 )
Bloomington	30478 P{lArB}smi35A1; ry506 18737 w1118; PBac{WH}smi35Af04169 35393 y1 sc* v1; P{TRiP.GL00313}attP2
Harvard	- PBac{PB}smi35Ac02848 - PBac{RB}smi35Ae00446 - PBac{RB}smi35Ae00552 - PBac{RB}smi35Ae00726 - PBac{WH}smi35Af04169 - PBac{WH}smi35Af08067
VDRC	v101376 P{KK108832}VIE-260B v40534 w1118; P{GD11347}v40534 v40535 w1118; P{GD11347}v40535
	More stocks available...
Genomic Clones ( 2 )
	BACR18J08 BACR20P10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 191 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH23334 LD02884
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH14052 GH26148 GM04027 HL01379 LD10161 LD15788 LD20817 LD33744 RE07240 RE07279 RE08636 RE23895 RE25451 RE29342 RE39912 RE50232 RE52138 RE54159 RE57192 RE58557 RE61885 RE62839 RE62880 RE67283 RE67284 RE67329 RE67401 RE67511 RE68544 RE71550 RH37190 RH47294 RH50420 RH52086 RH52772 RH56734 RH58324 RH59224 RH62615 RH64391 RH69078 RH71159
Other clones	4972 7971 12085 14891 29734 32473 45565 54362 58898 66031 66048 71536 73644 76587 97937 103520 121935 125452 125923 144424 147491 153056 153396 156948 161789 166915 184549 192532 193823 214275.1 274916 CK01.8D.H6 CK01.14D.H3 CK01.21D.C6 CK01.26A.G4 CK01.52D.G10 CK01.86B.H7 CK01.101A.D2 CK02015 Dmel_dig_003525_0623_1576 EC26018 EC051499 EC051507 EC052008 EC053981 EC054486 EC054973 EC055366 EC055369 EC056443 EK015030 EK038526 EK042308 EK043159 EK068132 EK077645 EK085209 EK093909 EK093954 EK106244 EK107208 EK113015 EK117540 EK121903 EK123861 EK142033 EK152203 EK161510 EK179255 EK181918 EK186761 EK193620 EK193953 EK199429 EK202549 EK206745 EK220652 EK226452 EK242058 EK247730 EK247947 EK249960 EK250849 EK256558 EK259932 EK266029 EK289463 EK293907 EK302610 EP09040 EP15704 ESG012b.E21.1_D10 FGC028C02 FGM323H04 RP004033759 RP004091341 RP004110598 RP004129991 RP004136388 RP004177619 RP004195728 RP004200324 RP004202769 RP004206396 RP004208701 RP004211650 RP004211943 RP004216225 RP004216692 RP004219844 RP004225460 RP004226348 RP004231257 RP004232467 RP004233547 RP004234259 RP004235768 RP004236392 RP004238305 RP004242985 RP004243964 RP004245148 RP004246602 RP004250083 RP004254329 RP004260082 RP004260310 RP004267262 RP004348708 RP004376690 RP004383507 RP004399959 RP004407092 RP004409006 RP004436454 RP004449185 RP004452520 RP004465459 RP004467291 RP004475182 RP004475372 RP004486811 RP004491904 RP004530871 RP004536030 RP004546270 RP004548819
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0016930 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34831
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: smi35A CG4551 (Kodira, 1999.11)
Source for database merge of
Additional comments	The relationship between the "smi35A" mutation and the "DYRK2" transcription unit is unclear; the "smi35A" mutation was isolated in a P-element mutagenesis screen as a mutation with an olfaction defective phenotype and "DYRK2" was considered to be the protein product of "smi35A" based on the location of the P-element (P{lacW}smi35Ak11509) in the mutant line. However, the smell-impaired phenotype can be lost in P{lacW}smi35Ak11509 flies and P{lacW}smi35Ak11509 embryos show normal expression and tyrosine-phosphorylation of "DYRK2". Further analysis is therefore needed to demonstrate that the "smi35A" phenotype is attributable to the "DYRK2" gene. (Lochhead et al., 2003)
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Area matching Drosophila ESTs AA440852 and AA541034. (Davies, 2001.3.15) Identified during a screen for olfactory mutants. (Anholt et al., 1996)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078840 NM_205988 NM_205989 NM_001038817 NM_001038818 RefSeq (Proteins) • NP_523564 NP_995710 NP_995711 NP_001033906 NP_001033907 DDBJ / EMBL / GenBank • AA141561 AA391489 AA440852 AA541034 AA567518 AA735281 AA802212 AAD47290 AAF44860 AAF53380 AAF53380.1 AAL39328 AAQ22557 AAS64705 AAS64705.1 AAS64706 AAS64706.1 ABC65900 ABC65901 AE003409 AF168467 AI061670 AI403817 AQ025808 AQ025968 AQ026114 AW940898 AW942031 AX094061 AY069183 BT010088 Entrez Gene - A searchable database of RefSeq genes. • 34831 UniProtKB/Swiss-Prot • Q9V3D5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Serine/threonine-protein kinase-like domain (IPR017442) Protein kinase, catalytic domain (IPR000719) Serine/threonine-protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0016930 DRSC - Results from RNAi screens. • FBgn0016930 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0016930 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4551-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0016930 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34831 InParanoid A subset of ortholog calls from InParanoid. • AAEL001504-PA Aedes aegypti (mosquito) AGAP008241-PA Anopheles gambiae (mosquito) XP_396369.2 Apis mellifera (honey bee) 211971 Branchiostoma floridae (lancelet) ENSBTAP00000009942 Bos taurus (bovine) CAL0003123 Candida albicans (a form of yeast) CE19878 Caenorhabditis elegans (worm) ENSCAFP00000022593 Canis familiaris (dog) Chro.50371 Cryptosporidium hominis (obligate parasite) JA04481 Caenorhabditis japonica (nematode) cgd5_250 Cryptosporidium parvum (protozoan parasite) ENSCPOP00000009160 Cavia porcellus (guinea pig) RP14186 Caenorhabditis remanei (nematode) ENSCSAVP00000005984 Ciona savignyi (sedentary tunicate) 149906 Capitella spl (polychaete worm) DDB0230102 Dictyostelium discoideum (amoeba) DEHA2C14080g Debaryomyces Hansenii (yeast) 51930 Daphnia pulex (daphnia) ENSDARP00000094915 Danio rerio (zebra fish) ENSECAP00000010385 Equus caballus (horse) XP_656048 Entamoeba histolytica (anaerobic protozoan) XP_656217 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000018183 Gymnopilus aculeatus (mushroom) GL50803_17417 Giardia lamblia (flagellated protozoan) 131581 Hypsipyla robusta (cedar shoot borer) ENSP00000010132 Homo sapiens (human) ISCW022190-PA Ixodes scapularis (deer tick) 117170 Lottia gigantea (owl limpet) LmjF35.1860 Leishmania major (virus) 32541 Monocosta brevicollis (choanoflagellate) ENSMODP00000022807 Monodelphis domestica (gray opossum) ENSMMUP00000039240 Macaca mulatta (rhesus monkey) ENSMUSP00000077606 Mus musculus (house mouse) 200667 Nematostella vectensis (starlet anemone) XP_001605197.1 Nasonia vitripennis (wasp) ENSOANP00000009442 Ornithorynchus anatinus (platypus) ENSORLP00000019828 Oryzias latipes (japanese killifish) PF14_0431 Plasmodium falciparum (protozoal parasite) PHUM001760-PA Pediculus humanus (human body louse) PP04805 Pristionchus pacificus (nematode) 147019 Physcomitrella patens (moss) ENSPPYP00000004751 Pongo pygmaeus (orangutan) 96448 Phytophthora ramorum (sudden oak death pathogen) ENSPTRP00000007788 Pan troglodytes (chimpanzee) ENSRNOP00000051169 Rattus norvegicus (norway rat) YJL141C Saccharomyces cerevisiae (budding yeast) SPAC2F7.03c Schizosaccharomyces pombe (fission yeast) XP_784683.2 Strongylocentrotus purpuratus (purple sea urchin) 33914 Trichoplax adhaerens (metazoa) TA19110 Theileria annulata (apicomplexan parasite) XP_972669.1 Tribolium castaneum (red flour beetle) Tc00.1047053510431.140 Trypanosoma cruzi (parasitic trypanosome) TP04_0880 Theileria parva (parasitic protozoan) ENSTRUP00000003716 Takifugu rubripes (pufferfish Takifugu) 3703.m00179 Tetrahymena thermophila (ciliate protozoa) 86498.m00531 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000051090 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34831 modMine - Data generated by the modENCODE project. • FBgn0016930 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17352 NV16659 NV13449 LH15563 LH16479 ISCW018301 FBgn0242170 FBgn0232088 FBgn0217105 FBgn0215660 FBgn0205227 FBgn0201661 FBgn0195743 FBgn0193427 FBgn0169806 FBgn0167935 JGI_V11_49628 JGI_V11_51930 FBgn0249311 FBgn0078256 FBgn0158651 FBgn0155974 FBgn0140129 FBgn0136869 FBgn0027101 FBgn0131444 FBgn0118077 FBgn0108646 FBgn0102467 FBgn0092624 CPIJ004687 CPIJ014802 BGIBMGA006111 BGIBMGA004611 GB18276 GB14600 AGAP008241 AGAP007847 AAEL001731 AAEL001504 PB25456 PHUM463810 PHUM574200 GLEAN_13573 GLEAN_14135
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	BG:DS01523.3 (Ashburner et al., 1999.10.12, Ashburner et al., 1999) CG4551 (Bhutkar et al., 2008, Levis, 2003.3.14, Labourier et al., 2002, Morrison et al., 2000, Molnar et al., 2006, Keleman et al., 2009.8.5, Ni et al., 2011.7.19) dDYRK2 (Lochhead et al., 2003, Lochhead et al., 2003, Kinstrie et al., 2006) DYRK (Morrison et al., 2000, Ashburner, 2000) Dyrk2 (Manning, 2001.10.15, Fedorowicz et al., 1999) DYRK2 (Cleghon, 1999.7.13) smi35A (Bhutkar et al., 2008, Molnar et al., 2006, Leatherbarrow and Halfon, 2009, Pickersgill et al., 2006, Morozova et al., 2007, Beckstead et al., 2007, Reis et al., 2010)
Name Synonym	Dual specificity tyrosine phosphorylation-regulated kinase (Fedorowicz et al., 1999) smell impaired 35A (Anholt et al., 1996, Morozova et al., 2007)
Secondary FlyBase IDs
	FBgn0027884
References ( 51 )
Generate a list of	All references relating to this gene ( 51 )
List References by type	Research paper  ( 21 ) Supplementary material  ( 7 ) Review  ( 1 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 3 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 2 ) Curated genome annotation  ( 2 ) Patent  ( 1 ) Computer file  ( 2 ) Automatic genome annotation  ( 1 )
Recent research papers ( 2 )
	Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Reis et al., 2010, PLoS Genet. 6(11): e1001206 A buoyancy-based screen of Drosophila larvae for fat-storage mutants reveals a role for sir2 in coupling fat storage to nutrient availability. [FBrf0212335] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...