U1-70K, snRNP70K, U1 snRNP, snRNP27D, 70K
Gene model reviewed during 5.44
Gene model reviewed during 5.49
Low-frequency RNA-Seq exon junction(s) not annotated.
Component of the U1 snRNP (By similarity). Interacts with Psi; essential for alternative splicing of P-element transposase. Interacts with the SMN complex.
Protein interactions mediated by the Arg-rich domain are not essential for viability, but do contribute to an essential U1 snRNP function.
The RRM domain mediates interaction with U1 RNA.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\snRNP-U1-70K using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\snRNP-U1-70K in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
RNAi screen using dsRNA made from templates generated with primers directed against this gene results in a long metaphase spindle with misaligned chromosomes when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.
A sequence comparison and numerical analysis of the RRM-containing (RNA recognition motif) proteins suggests that functionally related RRM-containing proteins have significant sequence similarities in their RRMs.
Isolated from a genomic library using a human U1 70K snRNP cDNA clone as a probe.
"AQ025594; BDGP:l (2)02107" was stated as revision.