FB2021_02, released April 13, 2021

Gene: Dmel\smid

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General Information
Symbol
Dmel\smid
Species
D. melanogaster
Name
smallminded
Annotation Symbol
CG8571
Feature Type
protein_coding_gene
FlyBase ID
FBgn0016983
Gene Model Status
Current
Stock Availability
7 publicly available
Gene Summary
AAA-protein family - ATPase - Mutants are defective in larval mitoses - expression of Smallminded in cells that undergo late embryonic or larval mitosis suggests a general role in promoting mitosis (Interactive Fly, smid )
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

l(3)j6B8

Key Links
Genomic Location
Cytogenetic map
65F9-65F10
Sequence location
3L:7,381,614..7,385,637 [+]
Recombination map
3-20
RefSeq locus
NT_037436 REGION:7381614..7385637
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (6 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables ATP binding
inferred from electronic annotation with InterPro:IPR003959, InterPro:IPR003960
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables ATPase activity
inferred from electronic annotation with InterPro:IPR003959, InterPro:IPR003960
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables preribosome binding
inferred from biological aspect of ancestor with PANTHER:PTN000554586
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in positive regulation of telomerase activity
inferred from biological aspect of ancestor with PANTHER:PTN000554586
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in ribosome biogenesis
inferred from biological aspect of ancestor with PANTHER:PTN000554586
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000554586
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
OTHER ATPASES -
The 'other ATPases group comprises ATPases that do not fit into any of the other major ATPase groups.
Summary (Interactive Fly)

AAA-protein family - ATPase - Mutants are defective in larval mitoses - expression of Smallminded in cells that undergo late embryonic or larval mitosis suggests a general role in promoting mitosis

Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
4

Please see the JBrowse view of Dmel\smid for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.45

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.39

Gene model reviewed during 5.46

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
smid-RA
FBtr0076851
NM_079235
3170
944
smid-RC
FBtr0301611
NM_001169900
3167
943
smid-RG
FBtr0331849
NM_001274583
3313
910
smid-RH
FBtr0331850
NM_001274584
3119
927
smid-RI
FBtr0333404
NM_206287
3080
910
Additional Transcript Data and Comments
Reported size (kB)

3.2 (northern blot)

(Long et al., 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
smid-PA
FBpp0089153
104.4
944
5.09
NP_523959
AAF50566
smid-PC
FBpp0290826
104.3
943
5.09
NP_001163371
ACZ94642
smid-PG
FBpp0304233
100.3
910
4.91
NP_001261512
AGB94207
smid-PH
FBpp0304234
102.6
927
5.02
NP_001261513
AGB94208
smid-PI
FBpp0305596
100.3
910
4.91
NP_996009
AAS65065
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

910 aa isoforms: smid-PG, smid-PI
Additional Polypeptide Data and Comments
Reported size (kDa)

943 (aa)

(Long et al., 1998)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\smid using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
Reporter: P{GawB}smidC161
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage
Bolwig nerve
(Renn et al., 1999)
sensory neuron
(Long et al., 1998)
imaginal disc
(Long et al., 1998)
neuroblast
(Long et al., 1998)
embryonic/larval central nervous system | restricted
(Long et al., 1998)
first instar larval stage
embryonic/larval peripheral nervous system | restricted
(Williams and Shepherd, 1999)
second instar larval stage -- third instar larval stage
larval lateral multidendritic neuron ldaB
(Nagel et al., 2012)
third instar larval stage
larval multidendritic class I neuron
(Tsubouchi et al., 2012, Hwang et al., 2007)
multidendritic neuron
(Landgraf et al., 2003)
chordotonal organ | lateral
(Landgraf et al., 2003)
eo neuron | subset
(Landgraf et al., 2003)
larval multidendritic class II neuron
(Tsubouchi et al., 2012, Hwang et al., 2007)
larval multidendritic class III neuron | faint | subset
(Tsubouchi et al., 2012)
larval dorsal multidendritic neuron ddaC
(Nagel et al., 2012)
larval dorsal multidendritic neuron ddaE
(Nagel et al., 2012)
pupal stage P7 -- adult stage
small field neuron

Comment: expression starts 32 hr APF

(Renn et al., 1999)
pharate adult stage
peripheral nervous system | restricted
(Williams and Shepherd, 1999)
adult stage
pb-eb-no neuron
(Renn et al., 1999)
ellipsoid body | restricted
(Renn et al., 1999)
protocerebral bridge | restricted
(Renn et al., 1999)
nodulus | restricted
(Renn et al., 1999)
leg
(Smith and Shepherd, 1996)
mesothoracic femoral chordotonal organ
(Williams et al., 2000, Smith and Shepherd, 1996)
metathoracic femoral chordotonal organ
(Williams et al., 2000, Smith and Shepherd, 1996)
prothoracic femoral chordotonal organ
(Williams et al., 2000, Smith and Shepherd, 1996)
sensory neuron of tibia | subset

Comment: Located at the tibial-tarsal joint

(Smith and Shepherd, 1996)
sensory neuron of metatarsus | subset

Comment: Located at the distal joint.

(Smith and Shepherd, 1996)
sensory neuron of tarsal segment 2 | subset

Comment: Located at the distal joint.

(Smith and Shepherd, 1996)
sensory neuron of tarsal segment 3 | subset

Comment: Located at the distal joint.

(Smith and Shepherd, 1996)
sensory neuron of tarsal segment 4 | subset

Comment: Located at the distal joint.

(Smith and Shepherd, 1996)
hair plate of prothoracic trochanter
(Smith and Shepherd, 1996)
hair plate of prothoracic coxa
(Smith and Shepherd, 1996)
femoral sensillum campaniformium | subset
(Smith and Shepherd, 1996)
wing
(Smith and Shepherd, 1996)
sensillum campaniformium of dorsal radius Sc4d
(Smith and Shepherd, 1996)
sensillum campaniformium of dorsal radius Sc25
(Smith and Shepherd, 1996)
sensillum campaniformium of dorsal radius Sc12
(Smith and Shepherd, 1996)
sensillum campaniformium of ventral radius Sc4v
(Smith and Shepherd, 1996)
sensillum of tegula
(Smith and Shepherd, 1996)
sensillum campaniformium of wing vein L3 | subset
(Smith and Shepherd, 1996)
haltere sensillum
(Smith and Shepherd, 1996)
adult abdomen
(Smith and Shepherd, 1996)
Wheeler's organ
(Smith and Shepherd, 1996)
sensory neuron of adult abdomen | subset
(Smith and Shepherd, 1996)
abdominal ventral multidendritic neuron | subset
(Smith and Shepherd, 1996)
abdominal lateral multidendritic neuron | subset
(Smith and Shepherd, 1996)
sensory neuron of central nervous system | subset

Comment: Neuron is probably mechanosensory

(Smith and Shepherd, 1996)
adult anterior dorsal mesothoracic nerve
(Smith and Shepherd, 1996)
sensory neuron of adult prothoracic segment
(Smith and Shepherd, 1996)
abdominal sensory neuron | subset
(Smith and Shepherd, 1996)
bipolar dendrite neuron
(Smith and Shepherd, 1996)
prothoracic neuromere | restricted
(Williams et al., 2000)
mesothoracic leg hair plate
(Williams et al., 2000)
metathoracic leg hair plate
(Williams et al., 2000)
prothoracic leg hair plate
(Williams et al., 2000)
sensillum campaniformium | subset of leg
(Williams et al., 2000)
abdominal dorsal multidendritic neuron ddaC
(Shimono et al., 2009)
abdominal dorsal multidendritic neuron ddaD
(Shimono et al., 2009)
abdominal dorsal multidendritic neuron ddaE
(Shimono et al., 2009)
abdominal lateral multidendritic neuron ldaA
(Shimono et al., 2009)
abdominal anterior ventral multidendritic neuron vdaa
(Shimono et al., 2009)
adult abdominal lateral multidendritic neuron ldaA-like
(Shimono et al., 2009)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\smid in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 7-8
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 14 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of smid
Transgenic constructs containing regulatory region of smid
Aberrations (Deficiencies and Duplications) ( 3 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (15)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\NVL
13 of 15
Yes
Yes
Hsap\SPATA5
3 of 15
No
No
Hsap\SPATA5L1
3 of 15
No
No
Hsap\VCP
3 of 15
No
No
7  
Hsap\PEX6
2 of 15
No
No
Hsap\ATAD1
1 of 15
No
No
Hsap\ATAD2B
1 of 15
No
Yes
Hsap\FIGN
1 of 15
No
No
Hsap\FIGNL1
1 of 15
No
No
Hsap\IQCA1
1 of 15
No
No
Hsap\IQCA1L
1 of 15
No
No
Hsap\NSF
1 of 15
No
No
8  
Hsap\PEX1
1 of 15
No
No
1  
Hsap\SPAST
1 of 15
No
No
7  
Hsap\TRIP13
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (15)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Nvl
13 of 15
Yes
Yes
Mmus\Spata5
3 of 15
No
No
Mmus\Vcp
3 of 15
No
No
Mmus\Pex6
2 of 15
No
No
Mmus\Spata5l1
2 of 15
No
Yes
Mmus\Atad1
1 of 15
No
No
Mmus\Fignl1
1 of 15
No
No
Mmus\Fignl2
1 of 15
No
No
Mmus\Fign
1 of 15
No
No
Mmus\Iqca1l
1 of 15
No
No
Mmus\Iqca
1 of 15
No
No
Mmus\Nsf
1 of 15
No
No
Mmus\Pex1
1 of 15
No
No
Mmus\Spast
1 of 15
No
No
Mmus\Trip13
1 of 15
No
No
Rattus norvegicus (Norway rat) (13)
Rnor\Nvl
12 of 13
Yes
Yes
Rnor\Spata5l1
3 of 13
No
No
Rnor\Spata5
3 of 13
No
No
Rnor\Vcp
3 of 13
No
No
Rnor\Pex6
2 of 13
No
No
Rnor\Atad1
1 of 13
No
No
Rnor\Fignl1
1 of 13
No
No
Rnor\Fign
1 of 13
No
No
Rnor\Iqca1l
1 of 13
No
No
Rnor\LOC100911599
1 of 13
No
No
Rnor\Pex1
1 of 13
No
No
Rnor\Spast
1 of 13
No
No
Rnor\Trip13
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (12)
Xtro\nvl
9 of 12
Yes
Yes
Xtro\spata5
3 of 12
No
No
Xtro\vcp
3 of 12
No
No
Xtro\spata5l1
2 of 12
No
Yes
Xtro\atad1
1 of 12
No
No
Xtro\fignl1
1 of 12
No
No
Xtro\fign
1 of 12
No
No
Xtro\gcg.2
1 of 12
No
No
Xtro\pex1
1 of 12
No
No
Xtro\pex6
1 of 12
No
No
Xtro\spast
1 of 12
No
No
Xtro\trip13
1 of 12
No
No
Danio rerio (Zebrafish) (19)
Drer\nvl
10 of 15
Yes
Yes
Drer\spata5l1
3 of 15
No
No
Drer\vcp
3 of 15
No
No
Drer\zgc:136908
3 of 15
No
No
Drer\pex6
2 of 15
No
No
Drer\spata5
2 of 15
No
No
Drer\atad1a
1 of 15
No
No
Drer\atad1b
1 of 15
No
No
Drer\fign
1 of 15
No
No
Drer\fignl1
1 of 15
No
No
Drer\iqca1
1 of 15
No
No
Drer\nsfa
1 of 15
No
No
Drer\nsfb
1 of 15
No
No
Drer\pex1
1 of 15
No
No
Drer\si:dkey-157g16.6
1 of 15
No
No
Drer\si:dkey-195m11.8
1 of 15
No
Yes
Drer\spast
1 of 15
No
No
Drer\trip13
1 of 15
No
No
Drer\zgc:153738
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (12)
Cele\mac-1
13 of 15
Yes
Yes
Cele\cdc-48.1
3 of 15
No
No
Cele\cdc-48.3
3 of 15
No
No
Cele\cdc-48.2
2 of 15
No
No
Cele\prx-6
2 of 15
No
No
Cele\figl-1
1 of 15
No
No
Cele\mspn-1
1 of 15
No
No
Cele\nsf-1
1 of 15
No
No
Cele\pch-2
1 of 15
No
No
Cele\prx-1
1 of 15
No
No
Cele\spas-1
1 of 15
No
No
Cele\ZK938.3
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (6)
Atha\CDC48C
7 of 9
Yes
Yes
Atha\AtCDC48B
1 of 9
No
No
Atha\AtCDC48C
1 of 9
No
No
Atha\CDC48
1 of 9
No
No
Atha\CDC48B
1 of 9
No
No
Atha\CIP111
1 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (10)
Scer\RIX7
13 of 15
Yes
Yes
Scer\AFG2
2 of 15
No
No
Scer\CDC48
2 of 15
No
No
Scer\PEX6
2 of 15
No
No
Scer\MSP1
1 of 15
No
No
Scer\PCH2
1 of 15
No
No
Scer\PEX1
1 of 15
No
No
Scer\SAP1
1 of 15
No
No
Scer\SEC18
1 of 15
No
No
Scer\YTA6
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (4)
Spom\SPBC16E9.10c
10 of 12
Yes
Yes
Spom\cdc48
1 of 12
No
No
Spom\pex6
1 of 12
No
No
Spom\SPBC56F2.07c
1 of 12
No
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091903EU )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00007252
Drosophila simulans
Dsim\GD14011
Drosophila sechellia
Dsec\GM14837
Drosophila erecta
Dere\GG14421
Drosophila yakuba
Dyak\GE21612
Drosophila ananassae
Dana\GF10639
Drosophila pseudoobscura pseudoobscura
Dpse\GA21172
Drosophila persimilis
Dper\GL26363
Drosophila willistoni
Dwil\GK17377
Drosophila virilis
Dvir\GJ12996
Drosophila mojavensis
Dmoj\GI12851
Drosophila grimshawi
Dgri\GH14878
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501C2 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17011025
Glossina morsitans
Tsetse fly
Gmor\GMOY003673
Glossina morsitans
Tsetse fly
Gmor\GMOY004249
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_05978
Mayetiola destructor
Hessian fly
Mdes\Mdes001700
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL000081
Anopheles darlingi
American malaria mosquito
Adar\ADAC006690
Anopheles gambiae
Malaria mosquito
Agam\AGAP006205
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W02FG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA008596
Danaus plexippus
Monarch butterfly
Dple\DPOGS201774-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL009395
Apis florea
Little honeybee
Aflo\2874194196
Apis mellifera
Western honey bee
Amel\GB43707
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP18126
Bombus terrestris
Buff-tailed bumblebee
Bter\15205058
Linepithema humile
Argentine ant
Lhum\LH12756
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002b21
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG021409
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG021407
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_09851
Tribolium castaneum
Red flour beetle
Tcas\TC002784
Pediculus humanus
Human body louse
Phum\PHUM563970
Rhodnius prolixus
Kissing bug
Rpro\RPRC001880
Cimex lectularius
Bed bug
Clec\CLEC005418
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005700
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_06169
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X02CW )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR012638
Ixodes scapularis
Black-legged tick
Isca\ISCW018606
Stegodyphus mimosarum
African social velvet spider
Smim\KFM74633.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur14g03380
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_316737
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_300935
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G024K )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Nvll_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Nvll
Ciona intestinalis
Vase tunicate
Cint\LOC100183707
Ciona intestinalis
Vase tunicate
Cint\LOC100187157
Gallus gallus
Domestic chicken
Ggal\NVL
Gallus gallus
Domestic chicken
Ggal\LOC430766
Gallus gallus
Domestic chicken
Ggal\LOC426240
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (15)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG5776
5 of 10
TER94
5 of 10
CG12010
4 of 10
Pex6
4 of 10
Pex1
3 of 10
CG4701
1 of 10
CG14183
1 of 10
CG16789
1 of 10
CG31495
1 of 10
comt
1 of 10
Fign
1 of 10
nmd
1 of 10
Nsf2
1 of 10
pch2
1 of 10
spas
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    smidj6B8
    ameliorates  tauopathy
    modeled by Hsap\MAPTGMR.Ex.PJ
    (Ambegaokar and Jackson, 2011)
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    NVL; nuclear VCP like
    13 of 15
    602426
        SPATA5; spermatogenesis associated 5
        3 of 15
        613940
          SPATA5L1; spermatogenesis associated 5 like 1
          3 of 15
              VCP; valosin containing protein
              3 of 15
              601023
               
              Functional Complementation Data
              Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
              Interactions
              Summary of Physical Interactions
              Summary of Genetic Interactions
              esyN Network Diagram
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              External Data
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              DroID - A comprehensive database of gene and protein interactions.
              InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Pathways
              Signaling Pathways (FlyBase)
              Metabolic Pathways
              External Data
              Linkouts
              KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
              Genomic Location and Detailed Mapping Data
              Chromosome (arm)
              3L
              Recombination map
              3-20
              Cytogenetic map
              65F9-65F10
              Sequence location
              3L:7,381,614..7,385,637 [+]
              FlyBase Computed Cytological Location
              Cytogenetic map
              Evidence for location
              65F9-65F10
              Limits computationally determined from genome sequence between P{PZ}l(3)0721708223&P{EP}Rac2EP3118 and P{lacW}Nmtj1C7
              Experimentally Determined Cytological Location
              Cytogenetic map
              Notes
              References
              66A1-66A22
              (Long, 1996.7.5)
              66A1-66A2
              (determined by in situ hybridisation)
              (Spradling et al., 1999)
              66A-66A
              (determined by in situ hybridisation)
              (Long et al., 1998)
              66A1-66A2
              (BDGP Project Members, 1994-1999)
              Experimentally Determined Recombination Data
              Location

              3-20

              (FlyBase, 2016)

              3-17.1

              (Comeron et al., 2012)

              3-

              (Long, 1996.7.5)
              Left of (cM)
              Right of (cM)
              Notes
              Stocks and Reagents
              Stocks (7)
              Genomic Clones (16)
               

              Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

              cDNA Clones (108)
               

              Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

              cDNA clones, fully sequenced
              BDGP DGC clones
              Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              Antibody Information
              Laboratory Generated Antibodies
               
              Commercially Available Antibodies
               
              Other Information
              Relationship to Other Genes
              Source for database identify of
              Source for database merge of

              Source for merge of: smid l(3)j6B8

              (Spradling et al., 1999)
              Additional comments
              Other Comments
              Origin and Etymology
              Discoverer
              Etymology

              Gene is named 'smallminded' due to the reduced central nervous system phenotype of mutants.

              (Long et al., 1998)
              Identification
              External Crossreferences and Linkouts ( 58 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              modMine - A data warehouse for the modENCODE project
              Linkouts
              ApoDroso - Functional genomic database for photoreceptor development, survival and function
              BioGRID - A database of protein and genetic interactions.
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              FLIGHT - Cell culture data for RNAi and other high-throughput technologies
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              FlyMine - An integrated database for Drosophila genomics
              Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
              InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
              KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Synonyms and Secondary IDs (8)
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              References (67)