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Gene Dmel\smid

General Information
Symbol	Dmel\smid	Species	D. melanogaster
Name	smallminded	Annotation symbol	CG8571
Feature type	protein_coding_gene	FlyBase ID	FBgn0016983
Gene Model Status	Current	Stock availability	8 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map	3-
Cytogenetic map	65F9-65F10	Sequence location	3L:7,374,714..7,378,737 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene smallminded is referred to in FlyBase by the symbol Dmel\smid (CG8571, FBgn0016983). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: ATPase activity. There is experimental evidence that it is involved in the biological process: neurogenesis. 19 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; central nervous system; embryonic/larval brain; embryonic/larval central nervous system. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: AAA+ ATPase domain; ATPase, AAA-type, conserved site; ATPase, AAA-type, core. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult hindgut, larval/adult Malpighian tubules, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1624482_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of smid. Gene sequence location is 3L:7374714..7378737.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 65F9-65F10   Limits computationally determined from genome sequence between P{PZ}l(3)0721708223&P{EP}Rac2EP3118 and P{lacW}Nmtj1C7
Experimentally Determined Cytological Location
Cytogenetic map Notes References 66A1-66A22     (Long, 1996.7.5) 66A1-66A2   (determined by in situ hybridisation)   (Spradling et al., 1999) 66A-66A   (determined by in situ hybridisation)   (Long et al., 1998) 66A1-66A2     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	3- (Long, 1996.7.5)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\smid for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45 Gene model reviewed during 5.39 Gene model reviewed during 5.46 Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters. Low-frequency RNA-seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) smid-RA FBtr0076851  NM_079235   3170   944 smid-RC FBtr0301611  NM_001169900   3167   943 smid-RG FBtr0331849  NM_001274583   3313   910 smid-RH FBtr0331850  NM_001274584   3119   927 smid-RI FBtr0333404  NM_206287   3080   910
Additional Transcript Data & Comments
Reported size (kB)	3.2 (northern blot) (Long et al., 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein smid-PA   FBpp0089153   104.4   944   5.09     NP_523959   AAF50566 smid-PC   FBpp0290826   104.3   943   5.09     NP_001163371   ACZ94642 smid-PG   FBpp0304233   100.3   910   4.91     NP_001261512   AGB94207 smid-PH   FBpp0304234   102.6   927   5.02     NP_001261513   AGB94208 smid-PI   FBpp0305596   100.3   910   4.91     NP_996009   AAS65065
Additional Polypeptide Data & Comments
Reported size (kDa)	943 (aa) (Long et al., 1998)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • AAA+ ATPase domain (IPR003593) ATPase, AAA-type, core (IPR003959) ATPase, AAA-type, conserved site (IPR003960) P-loop containing nucleoside triphosphate hydrolase (IPR027417)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202884   AA391124   AA440555   AA536455   AA538727   AA540976   AA695883   AA735455   AA949333   AE014296 AAF50566   AE014296 AAS65065   AE014296 ACZ94642   AE014296 AGB94207   AE014296 AGB94208   AI511843   AI512828   AI513943   AI546109   AQ025221   AQ034093   AY075495 AAL68305   BE975512   BF487606   BF497260   BG640280   BI165985   BI171824   BI216805   BI230564   BI231175   BI235745   BI236880   BI243921   BI363013   BI363613   BI365106   BI371278   BI372725   BI579773   BI636203   BP541685   BP543072   BP556449   BP557765   BT124778   CK660971   CO177433   CO188900   CO273332   CO276307   CO276813   CO276940   CO285663   CO298957   CO299340   CO302606   CO309037   CO315496   CO315648   CO318379   CO319049   EC060205   EC066318   EC074324   EC078276   EC081081   EC081125   EC198007   EC206811   EC208932   EC215112   EC215205   EC223094   EC243573   EC244510   ES689941   ES689977   ES692738   ES692751   EV591461   EV594732   GH941744   GH941918   GH942981   GH944890   GH946458   GH947795   GH948298   GH948388   GH948800   GH950358   GH950439   GH952151   GH954785   GH954820   GH955576   GH956099   GH957452   GH959432   GH959699   GH962927   GH963136   GH964483   GH965478   GH966149   GH966355   GH967568   GH967888   GH968930   GH971293   GH971677   GH972582   GH972816   GH972907   GH973005   GH974568   GH975524   GH978603   GH978649   GH978769   GH981303   GH983030   X99207 CAA67594
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	P91638 Q9VS62 Q8SXZ0 Q7KU82
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism | ubiquitous   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) central brain primordium   (Fisher et al., 2012) fat body/gonad primordium   (Fisher et al., 2012) germline cell   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic/larval fat body   (Fisher et al., 2012) embryonic/larval lymph gland   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) germline cell   (Fisher et al., 2012) gonad   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Long et al., 1998)
Additional Descriptive Data
	smid transcripts are detected in all phases of the life cycle with the highest levels in embryos. (Long et al., 1998)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
Reporter: P{GawB}smidC161 Stage Tissue/Position (including subcellular localization) Reference larval stage   Bolwig nerve   (Renn et al., 1999) sensory neuron   (Long et al., 1998) imaginal disc   (Long et al., 1998) neuroblast   (Long et al., 1998) embryonic/larval central nervous system | restricted   (Long et al., 1998) first instar larval stage   embryonic/larval peripheral nervous system | restricted   (Williams and Shepherd, 1999) third instar larval stage   class I dendritic arborizing neuron   (Hwang et al., 2007, Tsubouchi et al., 2012) multidendritic neuron   (Landgraf et al., 2003) chordotonal organ | lateral   (Landgraf et al., 2003) eo neuron | subset   (Landgraf et al., 2003) class II dendritic arborizing neuron   (Hwang et al., 2007, Tsubouchi et al., 2012) class III dendritic arborizing neuron | faint & subset   (Tsubouchi et al., 2012) pupal stage P7 -- adult stage   small field neuron   (Renn et al., 1999) Comment:expression starts 32 hr APF pharate adult stage   peripheral nervous system | restricted   (Williams and Shepherd, 1999) adult stage   pb-eb-no neuron   (Renn et al., 1999) ellipsoid body | restricted   (Renn et al., 1999) protocerebral bridge | restricted   (Renn et al., 1999) nodulus | restricted   (Renn et al., 1999) leg   (Smith and Shepherd, 1996) mesothoracic femoral chordotonal organ   (Smith and Shepherd, 1996, Williams et al., 2000) metathoracic femoral chordotonal organ   (Smith and Shepherd, 1996, Williams et al., 2000) prothoracic femoral chordotonal organ   (Smith and Shepherd, 1996, Williams et al., 2000) sensory neuron of tibia | subset   (Smith and Shepherd, 1996) Comment:Located at the tibial-tarsal joint sensory neuron of metatarsus | subset   (Smith and Shepherd, 1996) Comment:Located at the distal joint. sensory neuron of tarsal segment 2 | subset   (Smith and Shepherd, 1996) Comment:Located at the distal joint. sensory neuron of tarsal segment 3 | subset   (Smith and Shepherd, 1996) Comment:Located at the distal joint. sensory neuron of tarsal segment 4 | subset   (Smith and Shepherd, 1996) Comment:Located at the distal joint. hair plate of prothoracic trochanter   (Smith and Shepherd, 1996) hair plate of prothoracic coxa   (Smith and Shepherd, 1996) femoral sensillum campaniformium | subset   (Smith and Shepherd, 1996) wing   (Smith and Shepherd, 1996) sensillum campaniformium of dorsal radius Sc4d   (Smith and Shepherd, 1996) sensillum campaniformium of dorsal radius Sc25   (Smith and Shepherd, 1996) sensillum campaniformium of dorsal radius Sc12   (Smith and Shepherd, 1996) sensillum campaniformium of ventral radius Sc4vm   (Smith and Shepherd, 1996) sensillum of tegula   (Smith and Shepherd, 1996) sensillum campaniformium of wing vein L3 | subset   (Smith and Shepherd, 1996) haltere sensillum   (Smith and Shepherd, 1996) adult abdomen   (Smith and Shepherd, 1996) Wheeler's organ   (Smith and Shepherd, 1996) sensory neuron of adult abdomen | subset   (Smith and Shepherd, 1996) abdominal ventral multidendritic neuron | subset   (Smith and Shepherd, 1996) abdominal lateral multidendritic neuron | subset   (Smith and Shepherd, 1996) sensory neuron of central nervous system | subset   (Smith and Shepherd, 1996) Comment:Neuron is probably mechanosensory anterior dorsal mesothoracic nerve   (Smith and Shepherd, 1996) sensory neuron of adult prothoracic segment   (Smith and Shepherd, 1996) abdominal sensory neuron | subset   (Smith and Shepherd, 1996) bipolar dendrite neuron   (Smith and Shepherd, 1996) prothoracic neuromere | restricted   (Williams et al., 2000) mesothoracic leg hair plate   (Williams et al., 2000) metathoracic leg hair plate   (Williams et al., 2000) prothoracic leg hair plate   (Williams et al., 2000) sensillum campaniformium | subset of leg   (Williams et al., 2000)
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult hindgut, larval/adult Malpighian tubules, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    532.9 Larval Midgut    89.8 Larval Hindgut    163.9 Larval Malpighian Tubules    114.3 Larval Fat Body    110.3 Larval Salivary Gland    128.5 Larval Trachea    206.4 Larval Carcass    113 Adult Head    128.1 Adult Eye    130.675 Adult Brain    151.1 Adult Thoracic-Abdominal Ganglion    142.4 Adult Crop    139.6 Adult Midgut    89.2 Adult Hindgut    115 Adult Malpighian Tubules    121.5 Adult Fat Body    133.2 Adult Salivary Gland    136.7 Adult Heart    96.45 Adult VirginFemale Spermatheca    100.3 Adult InseminatedFemale Spermatheca    130.5 Adult Ovary    576.2 Adult Testis    58.9 Adult Male Accessory Gland    154 Adult Carcass    100.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  532.9 Larval Midgut    89.8 Larval Hindgut    163.9 Larval Malpighian Tubules    114.3 Larval Fat Body    110.3 Larval Salivary Gland    128.5 Larval Trachea    206.4 Larval Carcass    113 Adult Head    128.1 Adult Eye    130.675 Adult Brain    151.1 Adult Thoracic-Abdominal Ganglion    142.4 Adult Crop    139.6 Adult Midgut    89.2 Adult Hindgut    115 Adult Malpighian Tubules    121.5 Adult Fat Body    133.2 Adult Salivary Gland    136.7 Adult Heart    96.45 Adult VirginFemale Spermatheca    100.3 Adult InseminatedFemale Spermatheca    130.5 Adult Ovary  (576.2) Adult Testis    58.9 Adult Male Accessory Gland    154 Adult Carcass    100.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    532.9 Larval Midgut    89.8 Larval Hindgut    163.9 Larval Malpighian Tubules    114.3 Larval Fat Body    110.3 Larval Salivary Gland    128.5 Larval Trachea    206.4 Larval Carcass    113 Adult Head    128.1 Adult Eye    130.675 Adult Brain    151.1 Adult Thoracic-Abdominal Ganglion    142.4 Adult Crop    139.6 Adult Midgut    89.2 Adult Hindgut    115 Adult Malpighian Tubules    121.5 Adult Fat Body    133.2 Adult Salivary Gland    136.7 Adult Heart    96.45 Adult VirginFemale Spermatheca    100.3 Adult InseminatedFemale Spermatheca    130.5 Adult Ovary    576.2 Adult Testis    58.9 Adult Male Accessory Gland    154 Adult Carcass    100.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    532.9 Larval Midgut    89.8 Larval Hindgut    163.9 Larval Malpighian Tubules    114.3 Larval Fat Body    110.3 Larval Salivary Gland    128.5 Larval Trachea    206.4 Larval Carcass    113 Adult Head    128.1 Adult Eye    130.675 Adult Brain    151.1 Adult Thoracic-Abdominal Ganglion    142.4 Adult Crop    139.6 Adult Midgut    89.2 Adult Hindgut    115 Adult Malpighian Tubules    121.5 Adult Fat Body    133.2 Adult Salivary Gland    136.7 Adult Heart    96.45 Adult VirginFemale Spermatheca    100.3 Adult InseminatedFemale Spermatheca    130.5 Adult Ovary    576.2 Adult Testis    58.9 Adult Male Accessory Gland    154 Adult Carcass    100.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    532.9 Larval Midgut    89.8 Larval Hindgut    163.9 Larval Malpighian Tubules    114.3 Larval Fat Body    110.3 Larval Salivary Gland    128.5 Larval Trachea    206.4 Larval Carcass    113 Adult Head    128.1 Adult Eye    130.675 Adult Brain    151.1 Adult Thoracic-Abdominal Ganglion    142.4 Adult Crop    139.6 Adult Midgut    89.2 Adult Hindgut    115 Adult Malpighian Tubules    121.5 Adult Fat Body    133.2 Adult Salivary Gland    136.7 Adult Heart    96.45 Adult VirginFemale Spermatheca    100.3 Adult InseminatedFemale Spermatheca    130.5 Adult Ovary    576.2 Adult Testis    58.9 Adult Male Accessory Gland    154 Adult Carcass    100.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  532.9 Larval Midgut    89.8 Larval Hindgut    163.9 Larval Malpighian Tubules    114.3 Larval Fat Body    110.3 Larval Salivary Gland    128.5 Larval Trachea    206.4 Larval Carcass    113 Adult Head    128.1 Adult Eye    130.675 Adult Brain    151.1 Adult Thoracic-Abdominal Ganglion    142.4 Adult Crop    139.6 Adult Midgut    89.2 Adult Hindgut    115 Adult Malpighian Tubules    121.5 Adult Fat Body    133.2 Adult Salivary Gland    136.7 Adult Heart    96.45 Adult VirginFemale Spermatheca    100.3 Adult InseminatedFemale Spermatheca    130.5 Adult Ovary  576.2 Adult Testis    58.9 Adult Male Accessory Gland    154 Adult Carcass    100.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    532.9 Larval Midgut    89.8 Larval Hindgut    163.9 Larval Malpighian Tubules    114.3 Larval Fat Body    110.3 Larval Salivary Gland    128.5 Larval Trachea    206.4 Larval Carcass    113 Adult Head    128.1 Adult Eye    130.675 Adult Brain    151.1 Adult Thoracic-Abdominal Ganglion    142.4 Adult Crop    139.6 Adult Midgut    89.2 Adult Hindgut    115 Adult Malpighian Tubules    121.5 Adult Fat Body    133.2 Adult Salivary Gland    136.7 Adult Heart    96.45 Adult VirginFemale Spermatheca    100.3 Adult InseminatedFemale Spermatheca    130.5 Adult Ovary    576.2 Adult Testis    58.9 Adult Male Accessory Gland    154 Adult Carcass    100.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    532.9 Larval Midgut    89.8 Larval Hindgut    163.9 Larval Malpighian Tubules    114.3 Larval Fat Body    110.3 Larval Salivary Gland    128.5 Larval Trachea    206.4 Larval Carcass    113 Adult Head    128.1 Adult Eye    130.675 Adult Brain    151.1 Adult Thoracic-Abdominal Ganglion    142.4 Adult Crop    139.6 Adult Midgut    89.2 Adult Hindgut    115 Adult Malpighian Tubules    121.5 Adult Fat Body    133.2 Adult Salivary Gland    136.7 Adult Heart    96.45 Adult VirginFemale Spermatheca    100.3 Adult InseminatedFemale Spermatheca    130.5 Adult Ovary    576.2 Adult Testis    58.9 Adult Male Accessory Gland    154 Adult Carcass    100.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    128.1   NA  Eye    130.675   NA  Brain    151.1   532.9  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    142.4   NA  Crop    139.6   89.8  Midgut    89.2   163.9  Hindgut    115   114.3  Malpighian Tubules    121.5   110.3  Fat Body    133.2   128.5  Salivary Gland    136.7   NA  Heart    96.45   206.4  Trachea    NA   NA  VirginFemale Spermatheca    100.3   NA  InseminatedFemale Spermatheca    130.5   NA  Ovary    576.2   NA  Testis    58.9   NA  Male Accessory Gland    154   113  Carcass    100.1 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    61 central nervous system, larvae L3    85 central nervous system, pupae P8    23 head, virgin 1-day female    13 head, virgin 4-day female    14 head, virgin 20-day female    17 head, mated 1-day female    11 head, mated 4-day female    14 head, mated 20-day female    14 head, mated 1-day male    16 head, mated 4-day male    17 head, mated 20-day male    21 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    19 digestive system, 1-day adult    10 digestive system, 4-day adult    14 digestive system, 20-day adult    11 fat body, larvae L3 wandering    7 fat body, white prepupae    17 fat body, pupae P8    27 carcass, larvae L3 wandering    52 carcass, 1-day adult    10 carcass, 4-day adult    18 carcass, 20-day adult    16 ovary, virgin 4-day female    145 ovary, mated 4-day female    107 testis, mated 4-day male    15 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (61) central nervous system, larvae L3  (85) central nervous system, pupae P8    23 head, virgin 1-day female    13 head, virgin 4-day female    14 head, virgin 20-day female    17 head, mated 1-day female    11 head, mated 4-day female    14 head, mated 20-day female    14 head, mated 1-day male    16 head, mated 4-day male    17 head, mated 20-day male    21 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    19 digestive system, 1-day adult    10 digestive system, 4-day adult    14 digestive system, 20-day adult    11 fat body, larvae L3 wandering    7 fat body, white prepupae    17 fat body, pupae P8  (27) carcass, larvae L3 wandering  (52) carcass, 1-day adult    10 carcass, 4-day adult    18 carcass, 20-day adult    16 ovary, virgin 4-day female  (145) ovary, mated 4-day female  (107) testis, mated 4-day male    15 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    61 central nervous system, larvae L3    85 central nervous system, pupae P8    23 head, virgin 1-day female    13 head, virgin 4-day female    14 head, virgin 20-day female    17 head, mated 1-day female    11 head, mated 4-day female    14 head, mated 20-day female    14 head, mated 1-day male    16 head, mated 4-day male    17 head, mated 20-day male    21 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    19 digestive system, 1-day adult    10 digestive system, 4-day adult    14 digestive system, 20-day adult    11 fat body, larvae L3 wandering    7 fat body, white prepupae    17 fat body, pupae P8    27 carcass, larvae L3 wandering    52 carcass, 1-day adult    10 carcass, 4-day adult    18 carcass, 20-day adult    16 ovary, virgin 4-day female  (145) ovary, mated 4-day female  107 testis, mated 4-day male    15 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    61 central nervous system, larvae L3    85 central nervous system, pupae P8    23 head, virgin 1-day female    13 head, virgin 4-day female    14 head, virgin 20-day female    17 head, mated 1-day female    11 head, mated 4-day female    14 head, mated 20-day female    14 head, mated 1-day male    16 head, mated 4-day male    17 head, mated 20-day male    21 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    19 digestive system, 1-day adult    10 digestive system, 4-day adult    14 digestive system, 20-day adult    11 fat body, larvae L3 wandering    7 fat body, white prepupae    17 fat body, pupae P8    27 carcass, larvae L3 wandering    52 carcass, 1-day adult    10 carcass, 4-day adult    18 carcass, 20-day adult    16 ovary, virgin 4-day female    145 ovary, mated 4-day female    107 testis, mated 4-day male    15 accessory gland, mated 4-day male    11 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    61 central nervous system, larvae L3    85 central nervous system, pupae P8    23 head, virgin 1-day female    13 head, virgin 4-day female    14 head, virgin 20-day female    17 head, mated 1-day female    11 head, mated 4-day female    14 head, mated 20-day female    14 head, mated 1-day male    16 head, mated 4-day male    17 head, mated 20-day male    21 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    19 digestive system, 1-day adult    10 digestive system, 4-day adult    14 digestive system, 20-day adult    11 fat body, larvae L3 wandering    7 fat body, white prepupae    17 fat body, pupae P8    27 carcass, larvae L3 wandering    52 carcass, 1-day adult    10 carcass, 4-day adult    18 carcass, 20-day adult    16 ovary, virgin 4-day female    145 ovary, mated 4-day female    107 testis, mated 4-day male    15 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (61) central nervous system, larvae L3  (85) central nervous system, pupae P8    23 head, virgin 1-day female    13 head, virgin 4-day female    14 head, virgin 20-day female    17 head, mated 1-day female    11 head, mated 4-day female    14 head, mated 20-day female    14 head, mated 1-day male    16 head, mated 4-day male    17 head, mated 20-day male    21 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    19 digestive system, 1-day adult    10 digestive system, 4-day adult    14 digestive system, 20-day adult    11 fat body, larvae L3 wandering    7 fat body, white prepupae    17 fat body, pupae P8  27 carcass, larvae L3 wandering  (52) carcass, 1-day adult    10 carcass, 4-day adult    18 carcass, 20-day adult    16 ovary, virgin 4-day female  (145) ovary, mated 4-day female  (107) testis, mated 4-day male    15 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    61 central nervous system, larvae L3    85 central nervous system, pupae P8    23 head, virgin 1-day female    13 head, virgin 4-day female    14 head, virgin 20-day female    17 head, mated 1-day female    11 head, mated 4-day female    14 head, mated 20-day female    14 head, mated 1-day male    16 head, mated 4-day male    17 head, mated 20-day male    21 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    19 digestive system, 1-day adult    10 digestive system, 4-day adult    14 digestive system, 20-day adult    11 fat body, larvae L3 wandering    7 fat body, white prepupae    17 fat body, pupae P8    27 carcass, larvae L3 wandering    52 carcass, 1-day adult    10 carcass, 4-day adult    18 carcass, 20-day adult    16 ovary, virgin 4-day female  (145) ovary, mated 4-day female  107 testis, mated 4-day male    15 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    61 central nervous system, larvae L3    85 central nervous system, pupae P8    23 head, virgin 1-day female    13 head, virgin 4-day female    14 head, virgin 20-day female    17 head, mated 1-day female    11 head, mated 4-day female    14 head, mated 20-day female    14 head, mated 1-day male    16 head, mated 4-day male    17 head, mated 20-day male    21 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    19 digestive system, 1-day adult    10 digestive system, 4-day adult    14 digestive system, 20-day adult    11 fat body, larvae L3 wandering    7 fat body, white prepupae    17 fat body, pupae P8    27 carcass, larvae L3 wandering    52 carcass, 1-day adult    10 carcass, 4-day adult    18 carcass, 20-day adult    16 ovary, virgin 4-day female    145 ovary, mated 4-day female    107 testis, mated 4-day male    15 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    103 embryo 02-04hr    140 embryo 04-06hr    117 embryo 06-08hr    84 embryo 08-10hr    72 embryo 10-12hr    48 embryo 12-14hr    38 embryo 14-16hr    31 embryo 16-18hr    26 embryo 18-20hr    16 embryo 20-22hr    42 embryo 22-24hr    37 larva L1    21 larva L2    21 larva L3 12hr old    17 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    30 white prepupae new    30 white prepupae 12hr    33 white prepupae 24hr    33 pupae 2d postWPP    21 pupae 3d postWPP    12 pupae 4d postWPP    10 adult male 01day    12 adult male 05day    14 adult male 30day    13 adult female 01day    41 adult female 05day    73 adult female 30day    74 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (103) embryo 02-04hr  (140) embryo 04-06hr  (117) embryo 06-08hr  (84) embryo 08-10hr  (72) embryo 10-12hr  (48) embryo 12-14hr  (38) embryo 14-16hr  (31) embryo 16-18hr  26 embryo 18-20hr    16 embryo 20-22hr  (42) embryo 22-24hr  (37) larva L1    21 larva L2    21 larva L3 12hr old    17 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6  26 larva L3 puffstage 7-9  (30) white prepupae new  (30) white prepupae 12hr  (33) white prepupae 24hr  (33) pupae 2d postWPP    21 pupae 3d postWPP    12 pupae 4d postWPP    10 adult male 01day    12 adult male 05day    14 adult male 30day    13 adult female 01day  (41) adult female 05day  (73) adult female 30day  (74) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  103 embryo 02-04hr  (140) embryo 04-06hr  (117) embryo 06-08hr    84 embryo 08-10hr    72 embryo 10-12hr    48 embryo 12-14hr    38 embryo 14-16hr    31 embryo 16-18hr    26 embryo 18-20hr    16 embryo 20-22hr    42 embryo 22-24hr    37 larva L1    21 larva L2    21 larva L3 12hr old    17 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    30 white prepupae new    30 white prepupae 12hr    33 white prepupae 24hr    33 pupae 2d postWPP    21 pupae 3d postWPP    12 pupae 4d postWPP    10 adult male 01day    12 adult male 05day    14 adult male 30day    13 adult female 01day    41 adult female 05day    73 adult female 30day    74 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    103 embryo 02-04hr    140 embryo 04-06hr    117 embryo 06-08hr    84 embryo 08-10hr    72 embryo 10-12hr    48 embryo 12-14hr    38 embryo 14-16hr    31 embryo 16-18hr    26 embryo 18-20hr    16 embryo 20-22hr    42 embryo 22-24hr    37 larva L1    21 larva L2    21 larva L3 12hr old    17 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    30 white prepupae new    30 white prepupae 12hr    33 white prepupae 24hr    33 pupae 2d postWPP    21 pupae 3d postWPP    12 pupae 4d postWPP    10 adult male 01day    12 adult male 05day    14 adult male 30day    13 adult female 01day    41 adult female 05day    73 adult female 30day    74 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    103 embryo 02-04hr    140 embryo 04-06hr    117 embryo 06-08hr    84 embryo 08-10hr    72 embryo 10-12hr    48 embryo 12-14hr    38 embryo 14-16hr    31 embryo 16-18hr    26 embryo 18-20hr    16 embryo 20-22hr    42 embryo 22-24hr    37 larva L1    21 larva L2    21 larva L3 12hr old    17 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    30 white prepupae new    30 white prepupae 12hr    33 white prepupae 24hr    33 pupae 2d postWPP    21 pupae 3d postWPP    12 pupae 4d postWPP    10 adult male 01day    12 adult male 05day    14 adult male 30day    13 adult female 01day    41 adult female 05day    73 adult female 30day    74 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (103) embryo 02-04hr  (140) embryo 04-06hr  (117) embryo 06-08hr  (84) embryo 08-10hr  (72) embryo 10-12hr  (48) embryo 12-14hr  (38) embryo 14-16hr  31 embryo 16-18hr  26 embryo 18-20hr    16 embryo 20-22hr  (42) embryo 22-24hr  (37) larva L1    21 larva L2    21 larva L3 12hr old    17 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6  26 larva L3 puffstage 7-9  30 white prepupae new  30 white prepupae 12hr  (33) white prepupae 24hr  (33) pupae 2d postWPP    21 pupae 3d postWPP    12 pupae 4d postWPP    10 adult male 01day    12 adult male 05day    14 adult male 30day    13 adult female 01day  (41) adult female 05day  (73) adult female 30day  (74) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  103 embryo 02-04hr  140 embryo 04-06hr  117 embryo 06-08hr    84 embryo 08-10hr    72 embryo 10-12hr    48 embryo 12-14hr    38 embryo 14-16hr    31 embryo 16-18hr    26 embryo 18-20hr    16 embryo 20-22hr    42 embryo 22-24hr    37 larva L1    21 larva L2    21 larva L3 12hr old    17 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    30 white prepupae new    30 white prepupae 12hr    33 white prepupae 24hr    33 pupae 2d postWPP    21 pupae 3d postWPP    12 pupae 4d postWPP    10 adult male 01day    12 adult male 05day    14 adult male 30day    13 adult female 01day    41 adult female 05day    73 adult female 30day    74 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    103 embryo 02-04hr    140 embryo 04-06hr    117 embryo 06-08hr    84 embryo 08-10hr    72 embryo 10-12hr    48 embryo 12-14hr    38 embryo 14-16hr    31 embryo 16-18hr    26 embryo 18-20hr    16 embryo 20-22hr    42 embryo 22-24hr    37 larva L1    21 larva L2    21 larva L3 12hr old    17 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    30 white prepupae new    30 white prepupae 12hr    33 white prepupae 24hr    33 pupae 2d postWPP    21 pupae 3d postWPP    12 pupae 4d postWPP    10 adult male 01day    12 adult male 05day    14 adult male 30day    13 adult female 01day    41 adult female 05day    73 adult female 30day    74 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    75 Schneider line 2 Sg4    97 embryonic 1182-4H    79 embryonic GM2    51 embryonic Kc167    45 embryonic S1    96 embryonic S3    81 leg disc CME L1    86 wing disc CME-W2    78 wing disc ML-DmD8    81 wing disc ML-DmD9    78 wing disc ML-DmD16-c3    88 wing disc ML-DmD21    100 wing disc ML-DmD32    54 haltere disc ML-DmD17-c3    114 eye-antennal disc ML-DmD11    79 antennal disc ML-DmD20-c5    64 mixed discs ML-DmD4-c1    104 CNS ML-DmBG1-c1    164 CNS ML-DmBG2-c2    66 tumorous blood cells mbn2    43 ovary fGS/OSS    119 ovary OSC    137 ovary OSS    60 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (75) Schneider line 2 Sg4  (97) embryonic 1182-4H  (79) embryonic GM2  (51) embryonic Kc167  (45) embryonic S1  (96) embryonic S3  (81) leg disc CME L1  (86) wing disc CME-W2  (78) wing disc ML-DmD8  (81) wing disc ML-DmD9  (78) wing disc ML-DmD16-c3  (88) wing disc ML-DmD21  (100) wing disc ML-DmD32  (54) haltere disc ML-DmD17-c3  (114) eye-antennal disc ML-DmD11  (79) antennal disc ML-DmD20-c5  (64) mixed discs ML-DmD4-c1  (104) CNS ML-DmBG1-c1  (164) CNS ML-DmBG2-c2  (66) tumorous blood cells mbn2  (43) ovary fGS/OSS  (119) ovary OSC  (137) ovary OSS  (60) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    75 Schneider line 2 Sg4    97 embryonic 1182-4H    79 embryonic GM2    51 embryonic Kc167    45 embryonic S1    96 embryonic S3    81 leg disc CME L1    86 wing disc CME-W2    78 wing disc ML-DmD8    81 wing disc ML-DmD9    78 wing disc ML-DmD16-c3    88 wing disc ML-DmD21    100 wing disc ML-DmD32    54 haltere disc ML-DmD17-c3  (114) eye-antennal disc ML-DmD11    79 antennal disc ML-DmD20-c5    64 mixed discs ML-DmD4-c1  104 CNS ML-DmBG1-c1  (164) CNS ML-DmBG2-c2    66 tumorous blood cells mbn2    43 ovary fGS/OSS  (119) ovary OSC  (137) ovary OSS    60 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    75 Schneider line 2 Sg4    97 embryonic 1182-4H    79 embryonic GM2    51 embryonic Kc167    45 embryonic S1    96 embryonic S3    81 leg disc CME L1    86 wing disc CME-W2    78 wing disc ML-DmD8    81 wing disc ML-DmD9    78 wing disc ML-DmD16-c3    88 wing disc ML-DmD21    100 wing disc ML-DmD32    54 haltere disc ML-DmD17-c3    114 eye-antennal disc ML-DmD11    79 antennal disc ML-DmD20-c5    64 mixed discs ML-DmD4-c1    104 CNS ML-DmBG1-c1    164 CNS ML-DmBG2-c2    66 tumorous blood cells mbn2    43 ovary fGS/OSS    119 ovary OSC    137 ovary OSS    60 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    75 Schneider line 2 Sg4    97 embryonic 1182-4H    79 embryonic GM2    51 embryonic Kc167    45 embryonic S1    96 embryonic S3    81 leg disc CME L1    86 wing disc CME-W2    78 wing disc ML-DmD8    81 wing disc ML-DmD9    78 wing disc ML-DmD16-c3    88 wing disc ML-DmD21    100 wing disc ML-DmD32    54 haltere disc ML-DmD17-c3    114 eye-antennal disc ML-DmD11    79 antennal disc ML-DmD20-c5    64 mixed discs ML-DmD4-c1    104 CNS ML-DmBG1-c1    164 CNS ML-DmBG2-c2    66 tumorous blood cells mbn2    43 ovary fGS/OSS    119 ovary OSC    137 ovary OSS    60 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (75) Schneider line 2 Sg4  (97) embryonic 1182-4H  (79) embryonic GM2  (51) embryonic Kc167  (45) embryonic S1  (96) embryonic S3  (81) leg disc CME L1  (86) wing disc CME-W2  (78) wing disc ML-DmD8  (81) wing disc ML-DmD9  (78) wing disc ML-DmD16-c3  (88) wing disc ML-DmD21  (100) wing disc ML-DmD32  (54) haltere disc ML-DmD17-c3  (114) eye-antennal disc ML-DmD11  (79) antennal disc ML-DmD20-c5  (64) mixed discs ML-DmD4-c1  (104) CNS ML-DmBG1-c1  (164) CNS ML-DmBG2-c2  (66) tumorous blood cells mbn2  (43) ovary fGS/OSS  (119) ovary OSC  (137) ovary OSS  (60) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    75 Schneider line 2 Sg4    97 embryonic 1182-4H    79 embryonic GM2    51 embryonic Kc167    45 embryonic S1    96 embryonic S3    81 leg disc CME L1    86 wing disc CME-W2    78 wing disc ML-DmD8    81 wing disc ML-DmD9    78 wing disc ML-DmD16-c3    88 wing disc ML-DmD21    100 wing disc ML-DmD32    54 haltere disc ML-DmD17-c3  114 eye-antennal disc ML-DmD11    79 antennal disc ML-DmD20-c5    64 mixed discs ML-DmD4-c1  104 CNS ML-DmBG1-c1  (164) CNS ML-DmBG2-c2    66 tumorous blood cells mbn2    43 ovary fGS/OSS  119 ovary OSC  137 ovary OSS    60 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    75 Schneider line 2 Sg4    97 embryonic 1182-4H    79 embryonic GM2    51 embryonic Kc167    45 embryonic S1    96 embryonic S3    81 leg disc CME L1    86 wing disc CME-W2    78 wing disc ML-DmD8    81 wing disc ML-DmD9    78 wing disc ML-DmD16-c3    88 wing disc ML-DmD21    100 wing disc ML-DmD32    54 haltere disc ML-DmD17-c3    114 eye-antennal disc ML-DmD11    79 antennal disc ML-DmD20-c5    64 mixed discs ML-DmD4-c1    104 CNS ML-DmBG1-c1    164 CNS ML-DmBG2-c2    66 tumorous blood cells mbn2    43 ovary fGS/OSS    119 ovary OSC    137 ovary OSS    60 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    13 heat shock, 4-day adult    40 Cadmium 50 mM 6 hrs, larvae L3    17 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    40 Cadmium 100 mM 48 hrs, 4-day adult    70 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    36 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    22 Ethanol 2.5% 3 hrs, larvae L3    66 Ethanol 5% 3 hrs, larvae L3    19 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    18 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    65 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    65 Paraquat 10 mM 48 hrs, 4-day adult    53 Rotenone 2 μg 12 hrs, larvae L3    20 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    13 heat shock, 4-day adult  (40) Cadmium 50 mM 6 hrs, larvae L3    17 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult  (40) Cadmium 100 mM 48 hrs, 4-day adult  (70) Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult  (36) Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    22 Ethanol 2.5% 3 hrs, larvae L3  (66) Ethanol 5% 3 hrs, larvae L3    19 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    18 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (65) Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult  (65) Paraquat 10 mM 48 hrs, 4-day adult  (53) Rotenone 2 μg 12 hrs, larvae L3    20 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    13 heat shock, 4-day adult    40 Cadmium 50 mM 6 hrs, larvae L3    17 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    40 Cadmium 100 mM 48 hrs, 4-day adult    70 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    36 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    22 Ethanol 2.5% 3 hrs, larvae L3    66 Ethanol 5% 3 hrs, larvae L3    19 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    18 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    65 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    65 Paraquat 10 mM 48 hrs, 4-day adult    53 Rotenone 2 μg 12 hrs, larvae L3    20 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    13 heat shock, 4-day adult    40 Cadmium 50 mM 6 hrs, larvae L3    17 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    40 Cadmium 100 mM 48 hrs, 4-day adult    70 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    36 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    22 Ethanol 2.5% 3 hrs, larvae L3    66 Ethanol 5% 3 hrs, larvae L3    19 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    18 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    65 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    65 Paraquat 10 mM 48 hrs, 4-day adult    53 Rotenone 2 μg 12 hrs, larvae L3    20 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    13 heat shock, 4-day adult    40 Cadmium 50 mM 6 hrs, larvae L3    17 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    40 Cadmium 100 mM 48 hrs, 4-day adult    70 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    36 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    22 Ethanol 2.5% 3 hrs, larvae L3    66 Ethanol 5% 3 hrs, larvae L3    19 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    18 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    65 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    65 Paraquat 10 mM 48 hrs, 4-day adult    53 Rotenone 2 μg 12 hrs, larvae L3    20 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    13 heat shock, 4-day adult  (40) Cadmium 50 mM 6 hrs, larvae L3    17 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult  (40) Cadmium 100 mM 48 hrs, 4-day adult  (70) Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult  (36) Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    22 Ethanol 2.5% 3 hrs, larvae L3  (66) Ethanol 5% 3 hrs, larvae L3    19 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    18 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (65) Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult  (65) Paraquat 10 mM 48 hrs, 4-day adult  (53) Rotenone 2 μg 12 hrs, larvae L3    20 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    13 heat shock, 4-day adult    40 Cadmium 50 mM 6 hrs, larvae L3    17 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    40 Cadmium 100 mM 48 hrs, 4-day adult    70 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    36 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    22 Ethanol 2.5% 3 hrs, larvae L3    66 Ethanol 5% 3 hrs, larvae L3    19 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    18 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    65 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    65 Paraquat 10 mM 48 hrs, 4-day adult    53 Rotenone 2 μg 12 hrs, larvae L3    20 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    13 heat shock, 4-day adult    40 Cadmium 50 mM 6 hrs, larvae L3    17 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    40 Cadmium 100 mM 48 hrs, 4-day adult    70 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    36 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    22 Ethanol 2.5% 3 hrs, larvae L3    66 Ethanol 5% 3 hrs, larvae L3    19 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    18 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    65 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    65 Paraquat 10 mM 48 hrs, 4-day adult    53 Rotenone 2 μg 12 hrs, larvae L3    20 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_17 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • RE47719 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0016983 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8571-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for smid Stages(s) 7-8 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal smidGD13972 lethal | larval stage | recessive smidC161 lethal | recessive smidA55 smide5 smide17 smide74 smide80 smide106 smide122 smidGL72 smidj6B8 smidj8A6 smids2898 viable, with Scer\GAL4pnr-MD237 smidGD13972 Other Phenotypes Allele decreased cell number | somatic clone | third instar larval stage smidA55 smidGL72 locomotor rhythm defective | recessive smidC161 neuroanatomy defective | larval stage smidGD13972 visible, with Scer\GAL4pnr-MD237 smidGD13972 Phenotype manifest in Allele central nervous system smidC161 embryonic/larval brain smidC161 embryonic/larval brain | somatic clone | third instar larval stage smidA55 smidGL72 embryonic/larval central nervous system smidC161 ganglion mother cell | larval stage smidGD13972 neuroblast | larval stage smidC161 trichogen cell, with Scer\GAL4pnr-MD237 smidGD13972
Classical Alleles ( 14 )
For All Classical Alleles Show
Allele of smid Class Mutagen Stocks Known lesion smidj6B8 P-element activity 2 -- smidC161 loss of function allele P-element activity 1 Yes smidA55 ethyl methanesulfonate 0 -- smide106 0 Yes smide122 0 Yes smide17 0 Yes smide5 0 Yes smide74 0 Yes smide80 0 Yes smidEP3021 P-element activity 0 -- smidGL72 ethyl methanesulfonate 0 -- smidj8A6 P-element activity 0 -- smids2818 P-element activity 0 -- smids2898 P-element activity 0 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of smid Class Mutagen Stocks Known lesion smidGD13972 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes smidGL01024 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes smidGLV21069 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes smidKK104302 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes smidNIG.8571R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)BSC875 (Cook and Cook, 2010.5.7) Df(3L)Exel8104 (Ryder, 2004.4.26) Df(3L)pbl-X1 (Long et al., 1998, Long et al., 1998, Spradling et al., 1999, BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD13972} NA P{KK104302} NA P{NIG.8571R} NA P{TRiP.GL01024} NA P{TRiP.GLV21069} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}smidEP3021 NA insertion of enhancer trap P{lacW}smidj6B8 No P{lacW}smidj8A6 No P{lacW}smids2818 No P{lacW}smids2898 No insertion of enhancer trap binary system P{GawB}smidC161 No
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
neurogenesis inferred from mutant phenotype (Neumüller et al., 2011)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
ATPase activity inferred from sequence or structural similarity with Saccharomyces AFG2 (FlyBase, 1992-) non-traceable author statement (Spradling et al., 1999) ATP binding inferred from electronic annotation with InterPro:IPR003959, InterPro:IPR003960 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
smid - Arp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) smid - CG2931 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) smid - CG3570 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) smid - kay anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions smid allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64263 DroID - A comprehensive database of gene and protein interactions. • FBgn0016983 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38824
Orthologs
OrthoDB Orthologs (129) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG615GZV Dipteran inclusive ortholog search EOG64QT84 Insect inclusive ortholog search EOG6FXQ3G Arthropod inclusive ortholog search EOG62RBP7 Metazoa inclusive ortholog search EOG64XX8M
Orthologs in Drosophila Species (EOG615GZV)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\smid     Drosophila simulans   Dsim\GD14011 Y   Drosophila sechellia   Dsec\GM14837 Y   Drosophila erecta   Dere\GG14421 Y   Drosophila yakuba   Dyak\GE21612 Y   Drosophila ananassae   Dana\GF10639 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA21172 Y   Drosophila persimilis   Dper\GL26363 Y   Drosophila willistoni   Dwil\GK17377 Y   Drosophila virilis   Dvir\GJ12996 Y   Drosophila mojavensis   Dmoj\GI12852     Drosophila mojavensis   Dmoj\GI12851     Drosophila grimshawi   Dgri\GH14878 Y
Orthologs in non-Drosophila Dipterans (EOG64QT84)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL000081   Anopheles gambiae Malaria mosquito  Agam\AGAP006205
Orthologs in non-Dipteran Insects (EOG6FXQ3G)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC411003 Y Apis mellifera Western honey bee  Amel\GB43707 Y Apis mellifera Western honey bee  Amel\GB52193 Y Apis mellifera Western honey bee  Amel\GB52192 Y Apis mellifera Western honey bee  Amel\TER94 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG014806 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG010440 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG021409 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG008526 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG021407 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG014805 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH17086 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH21508 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH18239 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH15725 Y Atta cephalotes Leafcutter ant  Acep\ACEP19497 Y Atta cephalotes Leafcutter ant  Acep\ACEP24319 Y Atta cephalotes Leafcutter ant  Acep\ACEP22426 Y Atta cephalotes Leafcutter ant  Acep\ACEP24325 Y Atta cephalotes Leafcutter ant  Acep\ACEP14011 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO20098 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO16562 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO16885 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO15534 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17665 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL22455 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL21120 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL18984 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL21121 Y Linepithema humile Argentine ant  Lhum\LH17132 Y Linepithema humile Argentine ant  Lhum\LH17133 Y Linepithema humile Argentine ant  Lhum\LH12756 Y Linepithema humile Argentine ant  Lhum\LH15582 Y Linepithema humile Argentine ant  Lhum\LH22836 Y Linepithema humile Argentine ant  Lhum\LH15581 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB18972 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB23520 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB14748 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB23841 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB14749 Y Solenopsis invicta Red fire ant  Sinv\SINV14791 Y Solenopsis invicta Red fire ant  Sinv\SINV24121 Y Solenopsis invicta Red fire ant  Sinv\SINV14491 Y Solenopsis invicta Red fire ant  Sinv\SINV14508 Y Solenopsis invicta Red fire ant  Sinv\SINV24113 Y Solenopsis invicta Red fire ant  Sinv\SINV24170 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI008562 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI47232 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI002286 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI001046 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI000778 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI005700 Y Bombyx mori Silkmoth  Bmor\BGIBMGA008596 Y Bombyx mori Silkmoth  Bmor\BGIBMGA007201 Y Bombyx mori Silkmoth  Bmor\BGIBMGA003985 Y Bombyx mori Silkmoth  Bmor\BGIBMGA010499 Y Bombyx mori Silkmoth  Bmor\BGIBMGA008931 Y Pediculus humanus Human body louse  Phum\PHUM284050 Y Pediculus humanus Human body louse  Phum\PHUM234120 Y Pediculus humanus Human body louse  Phum\PHUM195510 Y Pediculus humanus Human body louse  Phum\PHUM263910 Y Pediculus humanus Human body louse  Phum\PHUM345890 Y Pediculus humanus Human body louse  Phum\PHUM180850 Y Pediculus humanus Human body louse  Phum\PHUM097430 Y Pediculus humanus Human body louse  Phum\PHUM563970 Y Pediculus humanus Human body louse  Phum\PHUM423210 Y Tribolium castaneum Red flour beetle  Tcas\TER94 Y Tribolium castaneum Red flour beetle  Tcas\TC004983 Y Tribolium castaneum Red flour beetle  Tcas\GLEAN_08415 Y Tribolium castaneum Red flour beetle  Tcas\TC002784 Y Tribolium castaneum Red flour beetle  Tcas\TC009993 Y
Orthologs in non-Insect Arthropods (EOG62RBP7)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_308570 Y Daphnia pulex Water flea  Dpux\JGI_V11_241712 Y Daphnia pulex Water flea  Dpux\rpb2 Y Daphnia pulex Water flea  Dpux\rbcL Y Daphnia pulex Water flea  Dpux\JGI_V11_306359 Y Daphnia pulex Water flea  Dpux\JGI_V11_302447 Y Daphnia pulex Water flea  Dpux\JGI_V11_300935 Y Daphnia pulex Water flea  Dpux\JGI_V11_101585 Y Ixodes scapularis Deer tick  Isca\ISCW005316 Y Ixodes scapularis Deer tick  Isca\ISCW016552 Y Ixodes scapularis Deer tick  Isca\ISCW008933 Y Ixodes scapularis Deer tick  Isca\ISCW018606 Y
Orthologs in non-Arthropod Metazoa (EOG64XX8M)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\cdc-48.2 Y Caenorhabditis elegans Nematode  Cele\mac-1 Y Caenorhabditis elegans Nematode  Cele\cdc-48.3 Y Caenorhabditis elegans Nematode  Cele\cdc-48.1 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_010294gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018934gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_019415gn Y Danio rerio Zebrafish  Drer\CH73-341P18.1 Y Danio rerio Zebrafish  Drer\spata5l1 Y Danio rerio Zebrafish  Drer\CABZ01085878.1 Y Danio rerio Zebrafish  Drer\vcp Y Danio rerio Zebrafish  Drer\nvl Y Xenopus tropicalis Western clawed frog  Xtro\spata5 Y Xenopus tropicalis Western clawed frog  Xtro\vcp Y Xenopus tropicalis Western clawed frog  Xtro\nvl Y Gallus gallus Domestic chicken  Ggal\NVL Y Gallus gallus Domestic chicken  Ggal\SPATA5 Y Gallus gallus Domestic chicken  Ggal\SPATA5L1 Y Gallus gallus Domestic chicken  Ggal\LOC430766 Y Gallus gallus Domestic chicken  Ggal\LOC426240 Y Mus musculus House mouse  Mmus\Nvl Y Mus musculus House mouse  Mmus\Spata5 Y Mus musculus House mouse  Mmus\Vcp Y Rattus norvegicus Norway rat  Rnor\Vcp Y Rattus norvegicus Norway rat  Rnor\Spata5 Y Rattus norvegicus Norway rat  Rnor\Nvl Y Rattus norvegicus Norway rat  Rnor\Spata5l1 Y Homo sapiens Human  Hsap\SPATA5 Y Homo sapiens Human  Hsap\SPATA5L1 Y Homo sapiens Human  Hsap\VCP Y Homo sapiens Human  Hsap\NVL Y
Human Orthologs (4)
Gene OMIM HGNC Hsap\SPATA5     Hsap\SPATA5L1     Hsap\VCP     Hsap\NVL
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD14011 Drosophila sechellia Dsec\GM14837 Drosophila erecta Dere\GG14421 Drosophila yakuba Dyak\GE21612 Drosophila ananassae Dana\GF10639 Drosophila pseudoobscura pseudoobscura Dpse\GA21172 Drosophila persimilis Dper\GL26363 Drosophila willistoni Dwil\GK17377 Drosophila virilis Dvir\GJ12996 Drosophila grimshawi Dgri\GH14878
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	27893 w*; P{GawB}smidC161/TM6B, Tb1 36808 y1 sc* v1; P{TRiP.GL01024}attP40 12070 y1 w*; P{lacW}smidj6B8/TM3, Sb1 35704 y1 sc* v1; P{TRiP.GLV21069}attP2/TM3, Sb1
Kyoto	111382 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{lacW}smidj6B8 P{neoFRT}80B/TM6B, P{Car20y}TPN1, Tb1
VDRC	v108178 P{KK104302}VIE-260B v35965 w1118; P{GD13972}v35965/TM3 v35967 w1118; P{GD13972}v35967/TM3
Genomic Clones ( 2 )
	BACR09E21 BACR11B04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 110 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE47719
Other clones	MIP20544
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT11395 AT22577 GM04712 LD03235 LD10221 LD15371 LD17070 LD18321 LD20191 LD21342 LD28188 LD41068 LD43381 LD44889 LD45985 LP19977 RE05994 RE13683 RE14267 RE19395 RE24077 RE31666 RE33009 RE41739 RE48508 RE50333 RE58141 RE59777 RE73853 SD11259 SD17814
Other clones	843 1107 10722 18326 56987 59699 156734 156782 158941 166931 bs43f08 CK01.52B.B4 CK01.64C.G8 CK01.70B.G5 CK01.146B.F11 Dmel_neb_003753_0415_3477 Dmel_neb_008946_0695_1542 EK042338 EK053443 EK110541 EK120322 EK122125 EK122441 EK169821 EK174164 EK175126 EK184537 EK259949 EK261654 EK262113 EK271837 EK276105 FGC004C10 FGC018E03 FGM303E12 FGM311B01 RP004058946 RP004085787 RP004094542 RP004107909 RP004109153 RP004148035 RP004172776 RP004173369 RP004194075 RP004196058 RP004200822 RP004205404 RP004215569 RP004219779 RP004232779 RP004235571 RP004255334 RP004256585 RP004257539 RP004258687 RP004261548 RP004262676 RP004340562 RP004360598 RP004388443 RP004390767 RP004391595 RP004395244 RP004408794 RP004414851 RP004448691 RP004461581 RP004465757 RP004480819 RP004482451 RP004491716 RP004503118 RP004518359 RP004520067 RP004554015 RP004558655
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0016983 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38824
Antibody Information
Other Information
Discoverer
Etymology
	Gene is named 'smallminded' due to the reduced central nervous system phenotype of mutants. (Long et al., 1998)
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: smid l(3)j6B8 (Spradling et al., 1999)
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079235 NM_206287 NM_001169900 NM_001274583 NM_001274584 RefSeq (Proteins) • NP_523959 NP_996009 NP_001163371 NP_001261512 NP_001261513 DDBJ / EMBL / GenBank • AA536455 AAF50566 AAL68305 AAS65065 ACZ94642 AGB94207 AGB94208 AQ025221 AQ034093 AY075495 BI363013 CAA67594 X99207 Entrez Gene - A searchable database of RefSeq genes. • 38824 UniProtKB/TrEMBL • P91638 Q7KU82 Q8SXZ0 Q9VS62
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • AAA+ ATPase domain (IPR003593) ATPase, AAA-type, core (IPR003959) ATPase, AAA-type, conserved site (IPR003960) P-loop containing nucleoside triphosphate hydrolase (IPR027417) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE47719
Linkouts
	BioGRID - A database of protein and genetic interactions • 64263 DroID - A comprehensive database of gene and protein interactions. • FBgn0016983 DRSC - Results from RNAi screens. • FBgn0016983 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0016983 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8571-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0016983 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38824 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /hjmuller/smalmnd1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38824 modMine - Data generated by the modENCODE project. • FBgn0016983
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	CG8571 (Keleman et al., 2009.8.5, Ni et al., 2011.7.19, Bridon et al., 2012) l(3)j6B8 (BDGP Project Members, 1994-1999, ) l(3)j8A6   l(3)s2898   smid (Altenhein et al., 2006, Svensson et al., 2007, Slack et al., 2006, Cook and Cook, 2010.5.7, Japanese National Institute of Genetics, 2012.5.21) Smid (Anholt and Williams, 2010)
Name Synonym	smallminded (Long, 1996.7.5, Long et al., 1998) small-minded (Slack et al., 2006, Bridon et al., 2012)
Secondary FlyBase IDs
	FBgn0011034 FBgn0011393 FBgn0011406 FBgn0024837
References ( 43 )
Generate a list of	All references relating to this gene ( 43 )
List References by type	Research paper  ( 17 ) Supplementary material  ( 5 ) Review  ( 2 ) Personal communication to FlyBase  ( 12 ) Abstract  ( 2 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 3 )
	Bridon et al., 2012, J. Proteome Res. 11(2): 927--940 Improvement of Phosphoproteome Analyses Using FAIMS and Decision Tree Fragmentation. Application to the Insulin Signaling Pathway in Drosophila melanogaster S2 Cells. [FBrf0217365] Tsubouchi et al., 2012, Curr. Biol. 22(22): 2124--2134 Dendritic Filopodia, Ripped Pocket, NOMPC, and NMDARs Contribute to the Sense of Touch in Drosophila Larvae. [FBrf0219946] Ambegaokar and Jackson, 2011, Hum. Mol. Genet. 20(24): 4947--4977 Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation. [FBrf0217690] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...