FB2020_06, released Dec 22, 2020

Gene: P1\cre

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General Information
Symbol
P1\cre
Species
P. Enterobacteria phage P1
Name
cre recombinase
Annotation Symbol
Feature Type
engineered_foreign_gene
FlyBase ID
FBgn0017409
Gene Model Status
Not Applicable
Stock Availability
20 publicly available
Other Summaries
Also Known As

Cre

Tag or Foreign Gene Data

Foreign sequence; species == Bacteriophage P1; gene == 'cre'; UniProt:P06956.

(FlyBase Curators, 1992-)
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (0 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
    -
    Summaries
    Gene Model and Products
    Number of Transcripts
    0
    Number of Unique Polypeptides
    0
    Protein Domains (via Pfam)
    Isoform displayed:
    Pfam protein domains
    InterPro name
    classification
    start
    end
    Protein Domains (via SMART)
    Isoform displayed:
    SMART protein domains
    InterPro name
    classification
    start
    end
    Comments on Gene Model
    Sequence Ontology: Class of Gene
    engineered_foreign_gene
    Transcript Data
    Annotated Transcripts
    Additional Transcript Data and Comments
    Reported size (kB)
    Comments
    External Data
    Crossreferences
    Polypeptide Data
    Annotated Polypeptides
    Polypeptides with Identical Sequences

     

    Additional Polypeptide Data and Comments
    Reported size (kDa)
    Comments
    External Data
    Crossreferences
    Linkouts
    Sequences Consistent with the Gene Model
    Nucleotide / Polypeptide Records
      Mapped Features

      Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping P1\cre using the Feature Mapper tool.

      External Data
      Crossreferences
      Linkouts
      Expression Data
      Expression Summary Ribbons
      Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
      For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
      Transcript Expression
      Additional Descriptive Data
      Marker for
       
      Subcellular Localization
      CV Term
      Polypeptide Expression
      Additional Descriptive Data
      Marker for
       
      Subcellular Localization
      CV Term
      Evidence
      References
      Expression Deduced from Reporters
      High-Throughput Expression Data
      Associated Tools

      GBrowse - Visual display of RNA-Seq signals

      View P1\cre in GBrowse 2
      RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
      Bulk Downloads
      RNA-Seq RPKM values for all genes
      Reference
      See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
      Developmental Proteome: Life Cycle
      Developmental Proteome: Embryogenesis
      External Data and Images
      Alleles, Insertions, and Transgenic Constructs
      Classical and Insertion Alleles ( 0 )
      For All Classical and Insertion Alleles Show
       
      Other relevant insertions
      Transgenic Constructs ( 291 )
      For All Alleles Carried on Transgenic Constructs Show
      Transgenic constructs containing/affecting coding region of P1\cre
      Transgenic constructs containing regulatory region of P1\cre
      Deletions and Duplications ( 0 )
      Phenotypes
      For more details about a specific phenotype click on the relevant allele symbol.
      Lethality
      Allele
      lethal, with Scer\GAL4hs.2sev
      partially lethal - majority die, with Scer\GAL4elav-C155
      viable, with Scer\GAL4prd.RG1
      Other Phenotypes
      Allele
      increased cell death, with Scer\GAL4dpp.blk1
      increased cell death, with Scer\GAL4en-e16E
      increased cell death | larval stage, with Scer\GAL4dpp.blk1
      increased cell death | larval stage, with Scer\GAL4en-e16E
      locomotor behavior defective | adult stage, with Scer\GAL4elav-C155, cazlox
      short lived, with Scer\GAL4elav-C155
      short lived, with Scer\GAL4elav-C155, cazlox
      size defective | adult stage
      some die during P-stage, with Scer\GAL4elav-C155, cazlox
      uncoordinated, with Scer\GAL4elav-C155
      visible, with Scer\GAL4Bx-MS1096
      visible, with Scer\GAL4dpp.blk1
      visible, with Scer\GAL4elav-C155
      visible, with Scer\GAL4en-e16E
      visible, with Scer\GAL4GMR.PF
      visible | drug conditional, with Scer\GAL4ey.PH
      Phenotype manifest in
      Allele
      embryonic/larval hypodermal muscle, with Scer\GAL4Mef2.PR
      eye, with Scer\GAL4elav-C155
      eye, with Scer\GAL4GMR.PF
      eye | drug conditional, with Scer\GAL4ey.PH
      retina, with Scer\GAL4GMR.PF
      wing, with Scer\GAL4Bx-MS1096
      wing, with Scer\GAL4dpp.blk1
      wing blade posterior compartment, with Scer\GAL4en-e16E
      wing disc, with Scer\GAL4dpp.blk1
      wing disc, with Scer\GAL4en-e16E
      Orthologs
      Downloads
      Download All DIOPT Orthologs
      Download All OrthoDB Orthologs
      Human Orthologs (via DIOPT v8.0)
      Homo sapiens (Human) (0)
      No records found.
      Model Organism Orthologs (via DIOPT v8.0)
      Drosophila melanogaster (Fruit fly) (0)
      No records found.
      Ortholog(s) in Drosophila melanogaster (via OrthoDB v9.1) ( None identified )
      No D. melanogaster orthologies identified
      Human Disease Associations
      FlyBase Human Disease Model Reports
        Disease Model Summary Ribbon
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Allele
        Disease
        Evidence
        References
        Potential Models Based on Orthology ( 0 )
        Human Ortholog
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Allele
        Disease
        Interaction
        References
        Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
        Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
        Homo sapiens (Human)
        Gene name
        Score
        OMIM
        OMIM Phenotype
        DO term
        Complementation?
        Transgene?
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Interactions Browser
        Summary of Genetic Interactions
        esyN Network Diagram
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        Recombination map
        Cytogenetic map
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (20)
        Genomic Clones (0)
         
          cDNA Clones (0)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequenced
          BDGP DGC clones
            Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                cDNA Clones, End Sequenced (ESTs)
                BDGP DGC clones
                  Other clones
                    RNAi and Array Information
                    Linkouts
                    Antibody Information
                    Laboratory Generated Antibodies
                     
                    Commercially Available Antibodies
                     
                    Other Information
                    Relationship to Other Genes
                    Source for database identify of
                    Source for database merge of
                    Additional comments
                    Other Comments

                    In the presence of a P1\cre transgene driven by a dual Hsp70-Dmau\mariner\T promoter, a w reporter gene flanked by P1\loxP sites is excised with virtually 100% efficiency both in somatic and germ cells. A strong maternal effect, resulting from P1\cre recombinase present in the oocyte, is observed as white or mosaic eye colour in F1 progeny. Excision in germ cells of the F1 yields a strong grand-maternal effect, observed as a highly skewed ratio of eye-colour phenotypes in the F2 generation. The excision reactions of P1\cre/P1\loxP and the related Scer\FLP1/Scer\FRT system are used to create lines in which transgenes are at exactly allelic sites in homologous chromosomes.

                    (Siegal and Hartl, 1996)
                    Origin and Etymology
                    Discoverer
                    Etymology
                    Identification
                    External Crossreferences and Linkouts ( 0 )
                    Synonyms and Secondary IDs (7)
                    Datasets (0)
                    Study focus (0)
                    Experimental Role
                    Project
                    Project Type
                    Title
                    References (33)