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Gene Dmel\ari-1

General Information
Symbol	Dmel\ari-1	Species	D. melanogaster
Name	ariadne	Annotation symbol	CG5659
Feature type	protein_coding_gene	FlyBase ID	FBgn0017418
Gene Model Status	Current	Stock availability	9 publicly available
Also Known As	ari, HL-V
Genomic Location
Chromosome (arm)	X	Recombination map	1-57.6--58.7
Cytogenetic map	16F7-16F7	Sequence location	X:18,024,444..18,031,682 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene ariadne is referred to in FlyBase by the symbol Dmel\ari-1 (CG5659, FBgn0017418). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: ubiquitin-protein ligase activity. The biological processes in which it is involved are not known. 14 alleles are reported. The phenotypes of these alleles are annotated with: mesothoracic extracoxal depressor muscle 66; germline cyst; thoracico-abdominal ganglion; ovariole; optic lobe; macrochaeta; coxal tergal remotor muscle; adult brain; cervical connective. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Tetracycline transcriptional regulator, TetR-like, C-terminal; Zinc finger, C3HC4 RING-type; Zinc finger, C6HC-type; Zinc finger, RING-type; Zinc finger, RING/FYVE/PHD-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult brain, larval hindgut, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1628016_s_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of ari-1. Gene sequence location is X:18024444..18031682.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Ying et al., 2011, PLoS ONE 6(9): e23863
FB2012_01	References Gradilla et al., 2011, Genetics 189(3): 871--883 Sequence features BKN28935 HFA20308
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 16F7-16F7   Limits computationally determined from genome sequence between P{EP}EP970 and P{EP}ari-1EP317
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	1-57.6--58.7 (Barbas, 1996.6.5)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\ari-1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) ari-1-RA FBtr0089506  NM_078675   2636   503 ari-1-RB FBtr0089507  NM_167610   2610   503 ari-1-RC FBtr0089508  NM_206777   2672   503 ari-1-RD FBtr0306057     4047   503
Additional Transcript Data & Comments
Reported size (kB)	4.3 (northern blot) (Aguilera et al., 2000)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein ari-1-PA   FBpp0088499   58.9   503   5.01     NP_523399   AAN09462 ari-1-PB   FBpp0088500   58.9   503   5.01     NP_728145   AAF48807 ari-1-PC   FBpp0089023   58.9   503   5.01     NP_996500   AAS65398 ari-1-PD   FBpp0297199   58.9   503   5.01
Additional Polypeptide Data & Comments
Reported size (kDa)	503 (aa); 59 (kD observed); 59 (kD predicted) (Aguilera et al., 2000)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, RING-type (IPR001841) Zinc finger, C6HC-type (IPR002867) Zinc finger, C3HC4 RING-type (IPR018957) Zinc finger, RING/FYVE/PHD-type (IPR013083) Tetracycline transcriptional regulator, TetR-like, C-terminal (IPR015893)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201535   AA392383   AA392719   AA392797   AA439254   AA538641   AA816758   AA950740   AE014298 AAF48807   AE014298 AAN09462   AE014298 AAS65398   AI511712   AI511849   AI513076   AI515163   AI518028   AQ025314   BI164615   BI165134   BI173716   BI213158   BI214360   BI229384   BI362437   BI364519   BI373390   BI374007   BI374587   BI375862   BI483810   BI484002   BI485771   BI579477   BT004849 AAO45205   CL526056   CO190743   CO263413   CO264113   CO276515   CO276552   CO277381   CO290191   CO297221   CO303851   CO307543   CO311766   CO317530   CO320029   CO332261   CO342918   CZ481645   CZ481646   EC071665   EC077543   EC081744   EC089238   EC216607   EC217646   EC217647   EC220401   EC227525   EC228822   EC242512   EC242705   EC243668   EC244859   EC247768   EC250982   EC252356   ES694887   EV600594   GH747837   GH748765   GH749347   GH749955   GH752336   GH753100   GH753492   GH753648   GH756039   GH756373   GH756831   GH760137   GH760678   GH772893   GH777299   GH780587   GH781567   GH783483   GH785483   GH785898   GH786518   GH791190   GH792321   GH801580   GH802241   GH803073   GH804253   GH809831   GH811650   GH812797   GH813538   GH815040   GH815745   GH817644   GH819512   GH820391   GH820796   GH826217   GH830021   GH836745   GH837444   GH840778   GH846966   GH847724   GH849598   GH849639   GH854934   GH856536   GH856749   GH856927   GH858001   GH859555   GH862343   GH869331   GH871904   GH875302   GH876431   GH877846   GH878635   GH883007   GH884031   GH887177   GH889987   GH891872   GH896362   GH897026   GH897745   GH901062   GH903606   GH905401   GH906008   GH910800   GH910862   GH913935   GH914094   GH916411   GH917156   GH917620   GH918627   GH919844   GH921376   GH922882   GH924706   GH925004   GH927043   GH927422   GH930807   GH931201   GH932179   GH934883   GH935744   GH938040   GH939435   GH939595   X98309 CAA66953   X98310 CAA66954
UniProtKB/Swiss-Prot	Q94981
UniProtKB/TrEMBL	Q86NL7 A4V4Q7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Aguilera et al., 2000) larval stage   organism | ubiquitous   (Aguilera et al., 2000) adult stage   adult central nervous system   (Aguilera et al., 2000) adult stage | female   gonad   (Aguilera et al., 2000) adult stage & oogenesis   nurse cell   (Aguilera et al., 2000) follicle cell   (Aguilera et al., 2000)
Additional Descriptive Data
	ari-1 transcripts are detected at all developmental stages, with levels increasing from embryogenesis onwards. The peak is reached at metamorphosis and maintained in adults. ari-1 is detected in all tissues, with high levels in the adult CNS and female gonads. (Aguilera et al., 2000)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Aguilera et al., 2000) unfertilized egg stage   unfertilized egg   (Aguilera et al., 2000)
Additional Descriptive Data
	Although ari-1 protein is detected mainly in the cytoplasm in Western blots of nuclear vs. cytoplasm enriched fractions, it does contain a putative nuclear localization signal. (Aguilera et al., 2000)
Marker for
Subcellular Localization
CV Term	cytoplasm (Aguilera et al., 2000)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0017418    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0017418 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0017418 expression level Developmental Stage   Expression Level embryo 00-02hr    4523 embryo 02-04hr    5146 embryo 04-06hr    1930 embryo 06-08hr    2270 embryo 08-10hr    2749 embryo 10-12hr    2342 embryo 12-14hr    2450 embryo 14-16hr    2668 embryo 16-18hr    2558 embryo 18-20hr    2135 embryo 20-22hr    2437 embryo 22-24hr    2437 larva L1    1137 larva L2    1062 larva L3 12hr old    1009 larva L3 puffstage 1-2    886 larva L3 puffstage 3-6    1986 larva L3 puffstage 7-9    2898 white prepupae new    3150 white prepupae 12hr    2399 white prepupae 24hr    1740 pupae 2d postWPP    1558 pupae 3d postWPP    1674 pupae 4d postWPP    2085 adult male 01day    2799 adult male 05day    2271 adult male 30day    1419 adult female 01day    2559 adult female 05day    2862 adult female 30day    2623 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4523) embryo 02-04hr  (5146) embryo 04-06hr  (1930) embryo 06-08hr  (2270) embryo 08-10hr  (2749) embryo 10-12hr  (2342) embryo 12-14hr  (2450) embryo 14-16hr  (2668) embryo 16-18hr  (2558) embryo 18-20hr  (2135) embryo 20-22hr  (2437) embryo 22-24hr  (2437) larva L1  (1137) larva L2  (1062) larva L3 12hr old  (1009) larva L3 puffstage 1-2  (886) larva L3 puffstage 3-6  (1986) larva L3 puffstage 7-9  (2898) white prepupae new  (3150) white prepupae 12hr  (2399) white prepupae 24hr  (1740) pupae 2d postWPP  (1558) pupae 3d postWPP  (1674) pupae 4d postWPP  (2085) adult male 01day  (2799) adult male 05day  (2271) adult male 30day  (1419) adult female 01day  (2559) adult female 05day  (2862) adult female 30day  (2623) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4523) embryo 02-04hr  (5146) embryo 04-06hr  (1930) embryo 06-08hr  (2270) embryo 08-10hr  (2749) embryo 10-12hr  (2342) embryo 12-14hr  (2450) embryo 14-16hr  (2668) embryo 16-18hr  (2558) embryo 18-20hr  (2135) embryo 20-22hr  (2437) embryo 22-24hr  (2437) larva L1    1137 larva L2    1062 larva L3 12hr old    1009 larva L3 puffstage 1-2    886 larva L3 puffstage 3-6  (1986) larva L3 puffstage 7-9  (2898) white prepupae new  (3150) white prepupae 12hr  (2399) white prepupae 24hr  (1740) pupae 2d postWPP  (1558) pupae 3d postWPP  (1674) pupae 4d postWPP  (2085) adult male 01day  (2799) adult male 05day  (2271) adult male 30day  1419 adult female 01day  (2559) adult female 05day  (2862) adult female 30day  (2623) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4523 embryo 02-04hr    5146 embryo 04-06hr    1930 embryo 06-08hr    2270 embryo 08-10hr    2749 embryo 10-12hr    2342 embryo 12-14hr    2450 embryo 14-16hr    2668 embryo 16-18hr    2558 embryo 18-20hr    2135 embryo 20-22hr    2437 embryo 22-24hr    2437 larva L1    1137 larva L2    1062 larva L3 12hr old    1009 larva L3 puffstage 1-2    886 larva L3 puffstage 3-6    1986 larva L3 puffstage 7-9    2898 white prepupae new    3150 white prepupae 12hr    2399 white prepupae 24hr    1740 pupae 2d postWPP    1558 pupae 3d postWPP    1674 pupae 4d postWPP    2085 adult male 01day    2799 adult male 05day    2271 adult male 30day    1419 adult female 01day    2559 adult female 05day    2862 adult female 30day    2623 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4523 embryo 02-04hr    5146 embryo 04-06hr    1930 embryo 06-08hr    2270 embryo 08-10hr    2749 embryo 10-12hr    2342 embryo 12-14hr    2450 embryo 14-16hr    2668 embryo 16-18hr    2558 embryo 18-20hr    2135 embryo 20-22hr    2437 embryo 22-24hr    2437 larva L1    1137 larva L2    1062 larva L3 12hr old    1009 larva L3 puffstage 1-2    886 larva L3 puffstage 3-6    1986 larva L3 puffstage 7-9    2898 white prepupae new    3150 white prepupae 12hr    2399 white prepupae 24hr    1740 pupae 2d postWPP    1558 pupae 3d postWPP    1674 pupae 4d postWPP    2085 adult male 01day    2799 adult male 05day    2271 adult male 30day    1419 adult female 01day    2559 adult female 05day    2862 adult female 30day    2623 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0017418 expression level Developmental Stage   Expression Level embryo 00-02hr    4523 embryo 02-04hr    5146 embryo 04-06hr    1930 embryo 06-08hr    2270 embryo 08-10hr    2749 embryo 10-12hr    2342 embryo 12-14hr    2450 embryo 14-16hr    2668 embryo 16-18hr    2558 embryo 18-20hr    2135 embryo 20-22hr    2437 embryo 22-24hr    2437 larva L1    1137 larva L2    1062 larva L3 12hr old    1009 larva L3 puffstage 1-2    886 larva L3 puffstage 3-6    1986 larva L3 puffstage 7-9    2898 white prepupae new    3150 white prepupae 12hr    2399 white prepupae 24hr    1740 pupae 2d postWPP    1558 pupae 3d postWPP    1674 pupae 4d postWPP    2085 adult male 01day    2799 adult male 05day    2271 adult male 30day    1419 adult female 01day    2559 adult female 05day    2862 adult female 30day    2623 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4523) embryo 02-04hr  (5146) embryo 04-06hr  (1930) embryo 06-08hr  (2270) embryo 08-10hr  (2749) embryo 10-12hr  (2342) embryo 12-14hr  (2450) embryo 14-16hr  (2668) embryo 16-18hr  (2558) embryo 18-20hr  (2135) embryo 20-22hr  (2437) embryo 22-24hr  (2437) larva L1  (1137) larva L2  (1062) larva L3 12hr old  (1009) larva L3 puffstage 1-2  (886) larva L3 puffstage 3-6  (1986) larva L3 puffstage 7-9  (2898) white prepupae new  (3150) white prepupae 12hr  (2399) white prepupae 24hr  (1740) pupae 2d postWPP  (1558) pupae 3d postWPP  (1674) pupae 4d postWPP  (2085) adult male 01day  (2799) adult male 05day  (2271) adult male 30day  (1419) adult female 01day  (2559) adult female 05day  (2862) adult female 30day  (2623) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4523) embryo 02-04hr  (5146) embryo 04-06hr  1930 embryo 06-08hr  2270 embryo 08-10hr  (2749) embryo 10-12hr  2342 embryo 12-14hr  2450 embryo 14-16hr  (2668) embryo 16-18hr  (2558) embryo 18-20hr  2135 embryo 20-22hr  2437 embryo 22-24hr  2437 larva L1    1137 larva L2    1062 larva L3 12hr old    1009 larva L3 puffstage 1-2    886 larva L3 puffstage 3-6  1986 larva L3 puffstage 7-9  (2898) white prepupae new  (3150) white prepupae 12hr  2399 white prepupae 24hr  1740 pupae 2d postWPP  1558 pupae 3d postWPP  1674 pupae 4d postWPP  2085 adult male 01day  (2799) adult male 05day  2271 adult male 30day  1419 adult female 01day  (2559) adult female 05day  (2862) adult female 30day  (2623) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4523 embryo 02-04hr    5146 embryo 04-06hr    1930 embryo 06-08hr    2270 embryo 08-10hr    2749 embryo 10-12hr    2342 embryo 12-14hr    2450 embryo 14-16hr    2668 embryo 16-18hr    2558 embryo 18-20hr    2135 embryo 20-22hr    2437 embryo 22-24hr    2437 larva L1    1137 larva L2    1062 larva L3 12hr old    1009 larva L3 puffstage 1-2    886 larva L3 puffstage 3-6    1986 larva L3 puffstage 7-9    2898 white prepupae new    3150 white prepupae 12hr    2399 white prepupae 24hr    1740 pupae 2d postWPP    1558 pupae 3d postWPP    1674 pupae 4d postWPP    2085 adult male 01day    2799 adult male 05day    2271 adult male 30day    1419 adult female 01day    2559 adult female 05day    2862 adult female 30day    2623 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4523 embryo 02-04hr    5146 embryo 04-06hr    1930 embryo 06-08hr    2270 embryo 08-10hr    2749 embryo 10-12hr    2342 embryo 12-14hr    2450 embryo 14-16hr    2668 embryo 16-18hr    2558 embryo 18-20hr    2135 embryo 20-22hr    2437 embryo 22-24hr    2437 larva L1    1137 larva L2    1062 larva L3 12hr old    1009 larva L3 puffstage 1-2    886 larva L3 puffstage 3-6    1986 larva L3 puffstage 7-9    2898 white prepupae new    3150 white prepupae 12hr    2399 white prepupae 24hr    1740 pupae 2d postWPP    1558 pupae 3d postWPP    1674 pupae 4d postWPP    2085 adult male 01day    2799 adult male 05day    2271 adult male 30day    1419 adult female 01day    2559 adult female 05day    2862 adult female 30day    2623 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0017418    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0017418 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult brain, larval hindgut, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0017418 expression level Tissue   Expression Level Larval Central Nervous System    66.4 Larval Midgut    88.2 Larval Hindgut    106.4 Larval Malpighian Tubules    90.4 Larval Fat Body    99.5 Larval Salivary Gland    36.7 Larval Trachea    57.35 Larval Carcass    79.45 Adult Head    72.1 Adult Eye    41.725 Adult Brain    188.6 Adult Thoracic-Abdominal Ganglion    69.6 Adult Crop    74.7 Adult Midgut    60.3 Adult Hindgut    77.3 Adult Malpighian Tubules no informative data Adult Fat Body    75.3 Adult Salivary Gland    38.5 Adult Heart    63.525 Adult VirginFemale Spermatheca    41.9 Adult InseminatedFemale Spermatheca    34.9 Adult Ovary    314.7 Adult Testis    57 Adult Male Accessory Gland    33.5 Adult Carcass    75.6 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    66.4 Larval Midgut    88.2 Larval Hindgut    106.4 Larval Malpighian Tubules    90.4 Larval Fat Body    99.5 Larval Salivary Gland    36.7 Larval Trachea    57.35 Larval Carcass    79.45 Adult Head    72.1 Adult Eye    41.725 Adult Brain    188.6 Adult Thoracic-Abdominal Ganglion    69.6 Adult Crop    74.7 Adult Midgut    60.3 Adult Hindgut    77.3 Adult Malpighian Tubules no informative data Adult Fat Body    75.3 Adult Salivary Gland    38.5 Adult Heart    63.525 Adult VirginFemale Spermatheca    41.9 Adult InseminatedFemale Spermatheca    34.9 Adult Ovary    314.7 Adult Testis    57 Adult Male Accessory Gland    33.5 Adult Carcass    75.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    66.4 Larval Midgut    88.2 Larval Hindgut    106.4 Larval Malpighian Tubules    90.4 Larval Fat Body    99.5 Larval Salivary Gland    36.7 Larval Trachea    57.35 Larval Carcass    79.45 Adult Head    72.1 Adult Eye    41.725 Adult Brain    188.6 Adult Thoracic-Abdominal Ganglion    69.6 Adult Crop    74.7 Adult Midgut    60.3 Adult Hindgut    77.3 Adult Malpighian Tubules no informative data Adult Fat Body    75.3 Adult Salivary Gland    38.5 Adult Heart    63.525 Adult VirginFemale Spermatheca    41.9 Adult InseminatedFemale Spermatheca    34.9 Adult Ovary    314.7 Adult Testis    57 Adult Male Accessory Gland    33.5 Adult Carcass    75.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    66.4 Larval Midgut    88.2 Larval Hindgut    106.4 Larval Malpighian Tubules    90.4 Larval Fat Body    99.5 Larval Salivary Gland    36.7 Larval Trachea    57.35 Larval Carcass    79.45 Adult Head    72.1 Adult Eye    41.725 Adult Brain    188.6 Adult Thoracic-Abdominal Ganglion    69.6 Adult Crop    74.7 Adult Midgut    60.3 Adult Hindgut    77.3 Adult Malpighian Tubules no informative data Adult Fat Body    75.3 Adult Salivary Gland    38.5 Adult Heart    63.525 Adult VirginFemale Spermatheca    41.9 Adult InseminatedFemale Spermatheca    34.9 Adult Ovary    314.7 Adult Testis    57 Adult Male Accessory Gland    33.5 Adult Carcass    75.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0017418 expression level Tissue   Expression Level Larval Central Nervous System    66.4 Larval Midgut    88.2 Larval Hindgut    106.4 Larval Malpighian Tubules    90.4 Larval Fat Body    99.5 Larval Salivary Gland    36.7 Larval Trachea    57.35 Larval Carcass    79.45 Adult Head    72.1 Adult Eye    41.725 Adult Brain    188.6 Adult Thoracic-Abdominal Ganglion    69.6 Adult Crop    74.7 Adult Midgut    60.3 Adult Hindgut    77.3 Adult Malpighian Tubules no informative data Adult Fat Body    75.3 Adult Salivary Gland    38.5 Adult Heart    63.525 Adult VirginFemale Spermatheca    41.9 Adult InseminatedFemale Spermatheca    34.9 Adult Ovary    314.7 Adult Testis    57 Adult Male Accessory Gland    33.5 Adult Carcass    75.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    66.4 Larval Midgut    88.2 Larval Hindgut    106.4 Larval Malpighian Tubules    90.4 Larval Fat Body    99.5 Larval Salivary Gland    36.7 Larval Trachea    57.35 Larval Carcass    79.45 Adult Head    72.1 Adult Eye    41.725 Adult Brain    188.6 Adult Thoracic-Abdominal Ganglion    69.6 Adult Crop    74.7 Adult Midgut    60.3 Adult Hindgut    77.3 Adult Malpighian Tubules no informative data Adult Fat Body    75.3 Adult Salivary Gland    38.5 Adult Heart    63.525 Adult VirginFemale Spermatheca    41.9 Adult InseminatedFemale Spermatheca    34.9 Adult Ovary    314.7 Adult Testis    57 Adult Male Accessory Gland    33.5 Adult Carcass    75.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    66.4 Larval Midgut    88.2 Larval Hindgut    106.4 Larval Malpighian Tubules    90.4 Larval Fat Body    99.5 Larval Salivary Gland    36.7 Larval Trachea    57.35 Larval Carcass    79.45 Adult Head    72.1 Adult Eye    41.725 Adult Brain    188.6 Adult Thoracic-Abdominal Ganglion    69.6 Adult Crop    74.7 Adult Midgut    60.3 Adult Hindgut    77.3 Adult Malpighian Tubules no informative data Adult Fat Body    75.3 Adult Salivary Gland    38.5 Adult Heart    63.525 Adult VirginFemale Spermatheca    41.9 Adult InseminatedFemale Spermatheca    34.9 Adult Ovary    314.7 Adult Testis    57 Adult Male Accessory Gland    33.5 Adult Carcass    75.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    66.4 Larval Midgut    88.2 Larval Hindgut    106.4 Larval Malpighian Tubules    90.4 Larval Fat Body    99.5 Larval Salivary Gland    36.7 Larval Trachea    57.35 Larval Carcass    79.45 Adult Head    72.1 Adult Eye    41.725 Adult Brain    188.6 Adult Thoracic-Abdominal Ganglion    69.6 Adult Crop    74.7 Adult Midgut    60.3 Adult Hindgut    77.3 Adult Malpighian Tubules no informative data Adult Fat Body    75.3 Adult Salivary Gland    38.5 Adult Heart    63.525 Adult VirginFemale Spermatheca    41.9 Adult InseminatedFemale Spermatheca    34.9 Adult Ovary    314.7 Adult Testis    57 Adult Male Accessory Gland    33.5 Adult Carcass    75.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules no informative data Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    72.1   NA  Eye    41.725   NA  Brain    188.6   66.4  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    69.6   NA  Crop    74.7   88.2  Midgut    60.3   106.4  Hindgut    77.3   90.4  Malpighian Tubules    no informative data   99.5  Fat Body    75.3   36.7  Salivary Gland    38.5   NA  Heart    63.525   57.35  Trachea    NA   NA  VirginFemale Spermatheca    41.9   NA  InseminatedFemale Spermatheca    34.9   NA  Ovary    314.7   NA  Testis    57   NA  Male Accessory Gland    33.5   79.45  Carcass    75.6 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_27
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0017418 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5659-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal ari-11199 lethal | embryonic stage | germline clone | non-rescuable maternal effect | recessive ari-13747 lethal | pupal stage | recessive ari-11199 ari-13747 ari-14822 ari-15777 semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 ari-1GD11725 viable ari-1EY08909 viable | poor (with ari-11199) ari-13747 viable | poor (with ari-13747) ari-11199 Sterility Allele female sterile (with Dp(1;3)JC153) ari-13747 fertile ari-1EY08909 Other Phenotypes Allele courtship behavior defective | male | recessive ari-1unspecified flightless | recessive ari-1unspecified jumping defective | recessive ari-1unspecified locomotor behavior defective | recessive ari-1unspecified neuroanatomy defective | adult stage | somatic clone ari-15777 neurophysiology defective | adult stage | somatic clone ari-15777 visible | recessive ari-1unspecified Phenotype manifest in Allele adult brain ari-15777 cervical connective ari-15777 coxal tergal remotor muscle (with ari-11199) ari-13747 coxal tergal remotor muscle (with ari-13747) ari-11199 germline cyst (with ari-11199) ari-13747 germline cyst (with ari-13747) ari-11199 germline cyst (with Dp(1;3)JC153) ari-13747 macrochaeta ari-1unspecified mesothoracic extracoxal depressor muscle 66 (with ari-11199) ari-13747 mesothoracic extracoxal depressor muscle 66 (with ari-13747) ari-11199 optic lobe ari-13747 ovariole (with ari-11199) ari-13747 ovariole (with ari-13747) ari-11199 ovariole (with Dp(1;3)JC153) ari-13747 photoreceptor cell R1 & rough endoplasmic reticulum | somatic clone ari-13747 photoreceptor cell R2 & rough endoplasmic reticulum | somatic clone ari-13747 photoreceptor cell R3 & rough endoplasmic reticulum | somatic clone ari-13747 photoreceptor cell R4 & rough endoplasmic reticulum | somatic clone ari-13747 photoreceptor cell R5 & rough endoplasmic reticulum | somatic clone ari-13747 photoreceptor cell R6 & rough endoplasmic reticulum | somatic clone ari-13747 photoreceptor cell R7 & rough endoplasmic reticulum | somatic clone ari-13747 rhabdomere R1 | somatic clone ari-13747 rhabdomere R2 | somatic clone ari-13747 rhabdomere R3 | somatic clone ari-13747 rhabdomere R4 | somatic clone ari-13747 rhabdomere R5 | somatic clone ari-13747 rhabdomere R6 | somatic clone ari-13747 thoracico-abdominal ganglion ari-15777
Classical Alleles ( 12 )
For All Classical Alleles Show
Allele of ari-1 Class Mutagen Stocks Known lesion ari-1e03888 piggyBac transposase 1 -- ari-1EP317 P-element activity 1 -- ari-1EY01960 P-element activity 1 -- ari-1EY08909 P-element activity 1 -- ari-1NP1063 1 -- ari-1UM-8334-3 1 -- ari-11199 ethyl methanesulfonate 0 Yes ari-13747 0 Yes ari-14822 0 Yes ari-15777 0 Yes ari-1e03889 piggyBac transposase 0 -- ari-1unspecified 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of ari-1 Class Mutagen Stocks Known lesion ari-1GD11725 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes ari-1JF03352 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Duplicated in	Dp(1;3)JC153 (Aguilera et al., 2000, de la Pompa, 1994) Dp(1;3)JC153-R4-III (Aguilera et al., 2000)
Not duplicated in	Dp(1;3)JC153-R5 (Aguilera et al., 2000)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11725} NA P{TRiP.JF03352} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}ari-1EP317 NA P{EPgy2}ari-1EY01960 NA P{EPgy2}ari-1EY08909 NA miscellaneous insertions P{RS3}ari-1UM-8334-3 NA PBac{RB}ari-1e03888 NA PBac{RB}ari-1e03889 NA insertion of enhancer trap binary system P{GawB}ari-1NP1063 No
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
DNA binding inferred from electronic annotation with InterPro:IPR015893 (FlyBase Curators et al., 2004-) ubiquitin-protein ligase activity non-traceable author statement (Swiss-Prot Project Members, 2001.8.20) zinc ion binding inferred from electronic annotation with InterPro:IPR001841, InterPro:IPR002867 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
cytoplasm non-traceable author statement (Swiss-Prot Project Members, 2001.8.20)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions ari-1 allele Gene References ari-11199 wupA (Ferrus et al., 1990, de la Pompa, 1994)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59116 DroID - A comprehensive database of gene and protein interactions. • FBgn0017418 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32796
Orthologs
Genome-wide drosophilid orthologs	Dana\GF20323 Dere\GG18141 Dgri\GH24087 Dmoj\GI15200 Dsec\GM22833 Dwil\GK16299 Dyak\GE15551
Curated drosophilid orthologs	Dmau\ari-1 (Moehring et al., 2004) Dsim\ari-1 (Moehring et al., 2004)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL013028-PA Aedes aegypti (mosquito) AGAP010891-PA Anopheles gambiae (mosquito) XP_623344.1 Apis mellifera (honey bee) XP_001947883.1 Acyrthosiphon pisum (pea aphid) At4g34370.1 Arabidopsis thaliana (wall cress) 9163 Batrachochytrium dendrobatidis (chytrid fungus) 277167 Branchiostoma floridae (lancelet) 277170 Branchiostoma floridae (lancelet) XP_001893040.1 Brugia malayi (roundworm nematode) BGIBMGA001417-PA Bombyx mori (silk worm) ENSBTAP00000008822 Bos taurus (bovine) CAL0003803 Candida albicans (a form of yeast) CN30848 Caenorhabditis brenneri (small nematode) CBP04753 Caenorhabditis briggsae (nematode) CE29680 Caenorhabditis elegans (worm) ENSCAFP00000026134 Canis familiaris (dog) CAGL0G07733g Candida glabrata (haploid yeast) ENSCINP00000001631 Ciona intestinalis (sea squirt) JA12699 Caenorhabditis japonica (nematode) cn08288 Cryptococcus neoformans (yeast-like fungus) CPIJ005416 Culex pipens (mosquito) ENSCPOP00000003308 Cavia porcellus (guinea pig) 175924 Chlamidomonas reinhardtii (green alga) RP05987 Caenorhabditis remanei (nematode) ENSCSAVP00000001616 Ciona savignyi (sedentary tunicate) 96432 Capitella spl (polychaete worm) DEHA2B01320g Debaryomyces Hansenii (yeast) 307315 Daphnia pulex (daphnia) ENSDARP00000006476 Danio rerio (zebra fish) ENSECAP00000017194 Equus caballus (horse) ENSGACP00000006322 Gymnopilus aculeatus (mushroom) ENSGALP00000002936 Gallus gallus (chicken) 100509 Hypsipyla robusta (cedar shoot borer) ENSP00000369217 Homo sapiens (human) ISCW001725-PA Ixodes scapularis (deer tick) KLLA0D02266g Kluyveromyces lactis (yeast) 178640 Lottia gigantea (owl limpet) LmjF30.2170 Leishmania major (virus) 32739 Monocosta brevicollis (choanoflagellate) ENSMODP00000012484 Monodelphis domestica (gray opossum) ENSMUSP00000026264 Mus musculus (house mouse) 235509 Nematostella vectensis (starlet anemone) XP_001607592.1 Nasonia vitripennis (wasp) ENSOANP00000021792 Ornithorynchus anatinus (platypus) ENSORLP00000008950 Oryzias latipes (japanese killifish) LOC_Os09g33876.1 Oryza sativa (asian rice) LOC_Os09g38630.1 Oryza sativa (asian rice) 8852 Ostreococcus tauri (green alga) PHUM000781-PA Pediculus humanus (human body louse) PP25165 Pristionchus pacificus (nematode) 141461 Physcomitrella patens (moss) ENSPPYP00000007505 Pongo pygmaeus (orangutan) 79370 Phytophthora ramorum (sudden oak death pathogen) 108400 Phytophthora sojae (root rot pathogen) 821209 Populus trichocarpa (black cottonwood) ENSPTRP00000012400 Pan troglodytes (chimpanzee) ENSRNOP00000013581 Rattus norvegicus (norway rat) 5049884 Sorghum bicolor (sorghum) YKR017C Saccharomyces cerevisiae (budding yeast) Smp_130600 Schistosoma mansoni (trematode parasite) SPAC328.02 Schizosaccharomyces pombe (fission yeast) XP_784503.1 Strongylocentrotus purpuratus (purple sea urchin) 30786 Trichoplax adhaerens (metazoa) XP_971560.1 Tribolium castaneum (red flour beetle) ENSTNIP00000011255 Tetraodon nigroviridis (green spotted pufferfish) 33851 Thalassiosira pseudonana (marine diatom) ENSTRUP00000035804 Takifugu rubripes (pufferfish Takifugu) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17376 NV13512 NV13048 NV10858 NV10857 LH16658 ISCW001725 FBgn0233124 FBgn0218301 FBgn0203793 FBgn0177703 JGI_V11_307315 FBgn0244060 FBgn0164473 FBgn0137949 FBgn0131543 FBgn0110357 FBgn0097330 CPIJ005416 CPIJ016079 BGIBMGA001417 ACYPI004803 GB15682 AGAP010891 AAEL013028 PHUM400430 GLEAN_04596
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Bloomington	10142 w1118 P{EP}ari-1EP317 29416 y1 v1; P{TRiP.JF03352}attP2 15844 y1 w67c23 P{EPgy2}ari-1EY01960 17507 y1 w67c23 P{EPgy2}ari-1EY08909
Harvard	- PBac{RB}ari-1e03888
Kyoto	124486 w1118 P{RS3}ari-1UM-8334-3 103873 y* w* P{GawB}ari-1NP1063 / FM7c
VDRC	v35029 w1118 P{GD11725}v35029 v39591 w1118 P{GD11725}v39591
Genomic Clones ( 1 )
	BACR48L05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 156 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE69116
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD04596 LD08464 LD11236 LD11833 LD11920 LD13766 LD18218 LD30848 LD37429 LD43204 LD43388 LD45305 LD46871 RE04324 RE04956 RE16805 RE18502 RE20138 RE27155 RE46988 RE49660 RE60660 RE61506 RE62221 RE63757 RE66759 RE67011 RE73520
Other clones	631 5181 35188 82741 148929 158193 176921 214321.52 273367 275354 CK01.4A.G3 CK01.21D.F1 CK01.94B.D11 CK01.98B.D12 CK01.105D.E4 CK01.147D.E7 Dmel_neb_011838_0918_0556 EK049454 EK073316 EK088450 EK121220 EK121320 EK124231 EK137522 EK216422 EK226244 EK242951 EK254811 EK268433 EK281744 EK302944 EP15737 RC0-DL0001-140700-113-H05 RP003000762 RP003003681 RP003039284 RP003040857 RP003044120 RP003055000 RP003061884 RP003076617 RP003081500 RP003082338 RP003083147 RP003093973 RP003098659 RP003102817 RP003104736 RP003107753 RP003108589 RP003130299 RP003131070 RP003135470 RP003141214 RP003155455 RP003158811 RP003160753 RP003168283 RP003171933 RP003172081 RP003173335 RP003175710 RP003185049 RP003188612 RP003198972 RP003208780 RP003211679 RP003211932 RP003215652 RP003229779 RP003238105 RP003241758 RP003241934 RP003246144 RP003250386 RP003257864 RP003259990 RP003261781 RP003276406 RP003285429 RP003288508 RP003292740 RP003306961 RP003309073 RP003318334 RP003329665 RP003330005 RP003336433 RP003343956 RP003351336 RP003352737 RP003355890 RP003357728 RP003359468 RP003365304 RP003400692 RP003405554 RP003408380 RP003420762 RP003456176 RP003462919 RP003470441 RP003477728 RP003478436 RP003485257 RP003493870 RP003494401 RP003510904 RP003512642 RP003522094 RP003536137 RP003540012 RP003541882 RP003564880 RP003570956 RP003595071 RP003604397 RP003615826 RP003635569 RP003639900 RP003645401 RP003657119 RP003660687 RP003661434 RP003665181 RP003672926 RP003677882
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0017418 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32796
Antibody Information
	polyclonal (Aguilera et al., 2000, Gradilla et al., 2011)
Other Information
Discoverer
Etymology
	The name "ariadne" refers to the loss of clues to find the correct path of axonal projection, and it evokes the Greek myth of the thread that Ariadne gave to Theseus to find his way in the Minotaur's labyrinth. (Aguilera et al., 2000)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: ari CG5659 (Li, 1999.11)
Source for database merge of	Source for merge of: ari l(1)16Fj (Ferrus, 1999.3.4)
Additional comments
Other Comments
	ari-1 is required for the correct differentiation of most cell types in the adult organism. (Aguilera et al., 2000)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078675 NM_167610 NM_206777 RefSeq (Proteins) • NP_523399 NP_728145 NP_996500 DDBJ / EMBL / GenBank • AAF48807 AAN09462 AAO45205 AAS65398 AQ025314 BI485771 BT004849 CAA66953 CAA66954 CL526056 CZ481645 CZ481646 X98309 X98310 Entrez Gene - A searchable database of RefSeq genes. • 32796 UniProtKB/Swiss-Prot • Q94981 UniProtKB/TrEMBL • A4V4Q7 Q86NL7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, RING-type (IPR001841) Zinc finger, C6HC-type (IPR002867) Zinc finger, C3HC4 RING-type (IPR018957) Zinc finger, RING/FYVE/PHD-type (IPR013083) Tetracycline transcriptional regulator, TetR-like, C-terminal (IPR015893)
Linkouts
	BioGRID - A database of protein and genetic interactions • 59116 DroID - A comprehensive database of gene and protein interactions. • FBgn0017418 DRSC - Results from RNAi screens. • FBgn0017418 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0017418 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5659-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0017418 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32796 InParanoid A subset of ortholog calls from InParanoid. • AAEL013028-PA Aedes aegypti (mosquito) AGAP010891-PA Anopheles gambiae (mosquito) XP_623344.1 Apis mellifera (honey bee) XP_001947883.1 Acyrthosiphon pisum (pea aphid) At4g34370.1 Arabidopsis thaliana (wall cress) 9163 Batrachochytrium dendrobatidis (chytrid fungus) 277167 Branchiostoma floridae (lancelet) 277170 Branchiostoma floridae (lancelet) XP_001893040.1 Brugia malayi (roundworm nematode) BGIBMGA001417-PA Bombyx mori (silk worm) ENSBTAP00000008822 Bos taurus (bovine) CAL0003803 Candida albicans (a form of yeast) CN30848 Caenorhabditis brenneri (small nematode) CBP04753 Caenorhabditis briggsae (nematode) CE29680 Caenorhabditis elegans (worm) ENSCAFP00000026134 Canis familiaris (dog) CAGL0G07733g Candida glabrata (haploid yeast) ENSCINP00000001631 Ciona intestinalis (sea squirt) JA12699 Caenorhabditis japonica (nematode) cn08288 Cryptococcus neoformans (yeast-like fungus) CPIJ005416 Culex pipens (mosquito) ENSCPOP00000003308 Cavia porcellus (guinea pig) 175924 Chlamidomonas reinhardtii (green alga) RP05987 Caenorhabditis remanei (nematode) ENSCSAVP00000001616 Ciona savignyi (sedentary tunicate) 96432 Capitella spl (polychaete worm) DEHA2B01320g Debaryomyces Hansenii (yeast) 307315 Daphnia pulex (daphnia) ENSDARP00000006476 Danio rerio (zebra fish) ENSECAP00000017194 Equus caballus (horse) ENSGACP00000006322 Gymnopilus aculeatus (mushroom) ENSGALP00000002936 Gallus gallus (chicken) 100509 Hypsipyla robusta (cedar shoot borer) ENSP00000369217 Homo sapiens (human) ISCW001725-PA Ixodes scapularis (deer tick) KLLA0D02266g Kluyveromyces lactis (yeast) 178640 Lottia gigantea (owl limpet) LmjF30.2170 Leishmania major (virus) 32739 Monocosta brevicollis (choanoflagellate) ENSMODP00000012484 Monodelphis domestica (gray opossum) ENSMUSP00000026264 Mus musculus (house mouse) 235509 Nematostella vectensis (starlet anemone) XP_001607592.1 Nasonia vitripennis (wasp) ENSOANP00000021792 Ornithorynchus anatinus (platypus) ENSORLP00000008950 Oryzias latipes (japanese killifish) LOC_Os09g33876.1 Oryza sativa (asian rice) LOC_Os09g38630.1 Oryza sativa (asian rice) 8852 Ostreococcus tauri (green alga) PHUM000781-PA Pediculus humanus (human body louse) PP25165 Pristionchus pacificus (nematode) 141461 Physcomitrella patens (moss) ENSPPYP00000007505 Pongo pygmaeus (orangutan) 79370 Phytophthora ramorum (sudden oak death pathogen) 108400 Phytophthora sojae (root rot pathogen) 821209 Populus trichocarpa (black cottonwood) ENSPTRP00000012400 Pan troglodytes (chimpanzee) ENSRNOP00000013581 Rattus norvegicus (norway rat) 5049884 Sorghum bicolor (sorghum) YKR017C Saccharomyces cerevisiae (budding yeast) Smp_130600 Schistosoma mansoni (trematode parasite) SPAC328.02 Schizosaccharomyces pombe (fission yeast) XP_784503.1 Strongylocentrotus purpuratus (purple sea urchin) 30786 Trichoplax adhaerens (metazoa) XP_971560.1 Tribolium castaneum (red flour beetle) ENSTNIP00000011255 Tetraodon nigroviridis (green spotted pufferfish) 33851 Thalassiosira pseudonana (marine diatom) ENSTRUP00000035804 Takifugu rubripes (pufferfish Takifugu) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32796 modMine - Data generated by the modENCODE project. • FBgn0017418 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17376 NV13512 NV13048 NV10858 NV10857 LH16658 ISCW001725 FBgn0233124 FBgn0218301 FBgn0203793 FBgn0177703 JGI_V11_307315 FBgn0244060 FBgn0164473 FBgn0137949 FBgn0131543 FBgn0110357 FBgn0097330 CPIJ005416 CPIJ016079 BGIBMGA001417 ACYPI004803 GB15682 AGAP010891 AAEL013028 PHUM400430 GLEAN_04596
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	ari (Moynihan et al., 1999, Cowley, 1998.9.24, de la Pompa, 1994, Ferrus et al., 1990, ) Ari-1 (Gradilla and Ferrus, 2004, Ying et al., 2011) ari-1 (Kuo et al., 2006, Martin et al., 2006, Gleason, 2005) ARI1_DROME (Storm and Sonnhammer, 2003) CG5659 (Misra, 2001.8.16, Mount, 2001.8.14, Perkins et al., 2009, Ying et al., 2011) HL-V (Ferrus, 1999.3.4, Prado et al., 1999) l(1)16Fj
Name Synonym	ariadne (Barbas, 1996.6.5, Barbas, 1996.6.5, Dason et al., 2009, Gleason, 2005) Ariadne-1 (Gradilla and Ferrus, 2004)
Secondary FlyBase IDs
	FBgn0014203
References ( 37 )
Generate a list of	All references relating to this gene ( 37 )
List References by type	Research paper  ( 14 ) Supplementary material  ( 3 ) Review  ( 1 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 2 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 2 ) Curated genome annotation  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 3 ) Letter  ( 1 )
Recent research papers ( 2 )
	Gradilla et al., 2011, Genetics 189(3): 871--883 Isoform-Specific Regulation of a Steroid Hormone Nuclear Receptor by an E3 Ubiquitin Ligase in Drosophila melanogaster. [FBrf0216551] Ying et al., 2011, PLoS ONE 6(9): e23863 Comprehensively Surveying Structure and Function of RING Domains from Drosophila melanogaster. [FBrf0215242] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...