FB2019_06, released Dec 19, 2019

Gene: Dmel\U2af38

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General Information
Symbol
Dmel\U2af38
Species
D. melanogaster
Name
U2 small nuclear riboprotein auxiliary factor 38
Annotation Symbol
CG3582
Feature Type
protein_coding_gene
FlyBase ID
FBgn0017457
Gene Model Status
Current
Stock Availability
10 publicly available
Gene Snapshot
U2 small nuclear riboprotein auxiliary factor 38 (U2af38) encodes the small subunit of the pre-mRNA splicing factor complex U2AF. This heterodimeric complex binds to the intron pyrimidine tract and targets the product of snf to the branch site early in spliceosome assembly. The U2af38 product binds to the AG dinucleotide at the 3' splice site. [Date last reviewed: 2018-09-20]
Other Summaries
Also Known As
U2AF, dU2AF38, dU2AF38
Key Links
Genomic Location
Cytogenetic map
21B7-21B8
Sequence location
2L:292,959..294,681 [-]
Recombination map
2-0.5
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the splicing factor SR family. (Q94535)
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
poly-pyrimidine tract binding
Predictions / Assertions
metal ion binding; mRNA binding; pre-mRNA 3'-splice site binding
Summaries
Gene Group (FlyBase)
SPLICEOSOME COMPLEX A -
Nuclear pre-mRNA splicing is catalyzed by the spliceosome which assembles in a step-wise manner. Complex A, the pre-spliceosome, is composed of U1 and U2 snRNPs and proteins involved in recognition of the 5' splice site and branch point. (Adapted from PMID:24452469 and PMID:23118483).
U2 SNRNP AUXILIARY FACTOR -
U2AF is a heterodimeric complex that binds to the intron pyrimidine tract between the branchpoint and the 3' splice site and targets U2 snRNP to the branch site early in spliceosome assembly. (Adapted from FBrf0103091).
Protein Function (UniProtKB)
Necessary for the splicing of pre-mRNA. Binds to the polypyrimidine tract of introns early during spliceosome assembly (By similarity).
(UniProt, Q94535)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\U2af38 or the JBrowse view of Dmel\U2af38 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.44
Gene model reviewed during 5.46
Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
U2af38-RA
FBtr0078133
NM_057860
1261
264
U2af38-RB
FBtr0333408
NM_001272885
1655
264
Additional Transcript Data and Comments
Reported size (kB)
1.3 (northern blot)
(Rudner et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
U2af38-PA
FBpp0077792
29.9
264
9.06
NP_477208
AAF51512
U2af38-PB
FBpp0305600
29.9
264
9.06
NP_001259814
AGB92351
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

264 aa isoforms: U2af38-PA, U2af38-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
264 (aa); 30 (kD predicted)
(Rudner et al., 1996)
Comments
External Data
Subunit Structure (UniProtKB)
Associates with a 65 kDa protein.
(UniProt, Q94535)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\U2af38 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (11 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
poly-pyrimidine tract binding
inferred from direct assay
(Rudner et al., 1998)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
metal ion binding
inferred from electronic annotation with InterPro:IPR000571
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
mRNA binding
inferred from sequence or structural similarity
(Lasko, 2000)
pre-mRNA 3'-splice site binding
inferred from biological aspect of ancestor with PANTHER:PTN000289700
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
mRNA splicing, via spliceosome
inferred from mutant phenotype
(Rudner et al., 1998)
regulation of alternative mRNA splicing, via spliceosome
inferred from mutant phenotype
(Katzenberger et al., 2009)
inferred from high throughput mutant phenotype
(Park et al., 2004)
RNA splicing
inferred from mutant phenotype
(Taliaferro et al., 2011)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
mRNA splicing, via spliceosome
inferred by curator from GO:0071011
(Herold et al., 2009)
inferred from biological aspect of ancestor with PANTHER:PTN000289700
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
precatalytic spliceosome
inferred from high throughput direct assay
(Herold et al., 2009)
U2AF
inferred from direct assay
(Rudner et al., 1998)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
nucleus
inferred by curator from GO:0000381
(Park et al., 2004)
spliceosomal complex
inferred from biological aspect of ancestor with PANTHER:PTN000289700
(assigned by GO_Central )
(Gaudet et al., 2011)
U2AF
inferred from biological aspect of ancestor with PANTHER:PTN000289700
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | female
(Rudner et al., 1996)
adult stage | male
(Rudner et al., 1996)
Additional Descriptive Data
U2af38 transcripts are detected in RNA from adult flies. Levels are reduced in mutants.
(Rudner et al., 1996)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
precatalytic spliceosome
inferred from high throughput direct assay
(Herold et al., 2009)
U2AF
inferred from direct assay
(Rudner et al., 1998)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\U2af38 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 3 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 16 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of U2af38
Transgenic constructs containing regulatory region of U2af38
Deletions and Duplications ( 8 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\U2AF1L4
10 of 15
Yes
Yes
Hsap\U2AF1L5
10 of 15
Yes
Yes
Hsap\U2AF1
9 of 15
No
Yes
 
Hsap\ZRSR2
2 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\U2af1
15 of 15
Yes
Yes
Mmus\U2af1l4
8 of 15
No
Yes
Mmus\Zrsr1
2 of 15
No
No
Mmus\Zrsr2
1 of 15
No
No
Rattus norvegicus (Norway rat) (4)
Rnor\U2af1
10 of 13
Yes
Yes
Rnor\U2af1l4
7 of 13
No
Yes
Rnor\Zrsr1
2 of 13
No
No
Rnor\Zrsr2
2 of 13
No
No
Xenopus tropicalis (Western clawed frog) (1)
Xtro\u2af1
8 of 12
Yes
Yes
Danio rerio (Zebrafish) (2)
Drer\u2af1
9 of 15
Yes
Yes
Drer\zrsr2
2 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\uaf-2
13 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (4)
Atha\ATU2AF35A
8 of 9
Yes
Yes
Atha\U2AF35B
8 of 9
Yes
Yes
Atha\AT1G10320
1 of 9
No
No
Atha\AT3G44785
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\SPAP8A3.06
12 of 12
Yes
Yes
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190FOW )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\U2af38
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00000029
Drosophila simulans
Dsim\GD22967
Drosophila sechellia
Dsec\GM16679
Drosophila erecta
Dere\GG24659
Drosophila yakuba
Dyak\GE16227
Drosophila ananassae
Dana\GF24893
Drosophila pseudoobscura pseudoobscura
Dpse\GA17536
Drosophila persimilis
Dper\GL25824
Drosophila willistoni
Dwil\GK14823
Drosophila virilis
Dvir\GJ17240
Drosophila mojavensis
Dmoj\GI15018
Drosophila grimshawi
Dgri\GH10217
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150B3S )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17010403
Glossina morsitans
Tsetse fly
Gmor\GMOY003598
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_03934
Mayetiola destructor
Hessian fly
Mdes\Mdes008962
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL006713
Anopheles darlingi
American malaria mosquito
Adar\ADAC004587
Anopheles gambiae
Malaria mosquito
Agam\AGAP002956
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ016711
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ003901
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0CSE )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA010333
Danaus plexippus
Monarch butterfly
Dple\DPOGS208546-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL008763
Apis florea
Little honeybee
Aflo\2355231988
Apis mellifera
Western honey bee
Amel\U2af38
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP22110
Bombus terrestris
Buff-tailed bumblebee
Bter\15213296
Linepithema humile
Argentine ant
Lhum\LH14347
Linepithema humile
Argentine ant
Lhum\LH17509
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001aee
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG003158
Tribolium castaneum
Red flour beetle
Tcas\TC031227
Pediculus humanus
Human body louse
Phum\PHUM349680
Rhodnius prolixus
Kissing bug
Rpro\RPRC014585
Cimex lectularius
Bed bug
Clec\CLEC012539
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI001339
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_15613
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0CPW )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR002827
Strigamia maritima
European centipede
Smar\SMAR014570
Ixodes scapularis
Black-legged tick
Isca\ISCW019664
Stegodyphus mimosarum
African social velvet spider
Smim\KFM65978.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur24g02190
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_52589
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0CUI )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_002416gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Unk_16
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-U2af1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Zrsr2
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000004086
Ciona intestinalis
Vase tunicate
Cint\zf(c3h)-13
Gallus gallus
Domestic chicken
Ggal\U2AF1
Gallus gallus
Domestic chicken
Ggal\ZRSR2
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (1)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG3294
5 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    U2AF1L4; U2 small nuclear RNA auxiliary factor 1 like 4
    10 of 15
    601080
        U2AF1L5; U2 small nuclear RNA auxiliary factor 1 like 5
        10 of 15
            U2AF1; U2 small nuclear RNA auxiliary factor 1
            9 of 15
            191317
                 
                Functional Complementation Data
                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                Interactions
                Summary of Physical Interactions
                esyN Network Diagram
                Show neighbor-neighbor interactions:
                Select Layout:
                Legend:
                Protein
                RNA
                Selected Interactor(s)
                Interactions Browser
                View in Interactions Browser
                Please see the Physical Interaction reports below for full details
                protein-protein
                Physical Interaction
                Assay
                References
                U2af38 - LS2
                anti tag coimmunoprecipitation, western blot, pull down
                (Taliaferro et al., 2011)
                U2af38 - U2af50
                pull down, molecular weight estimation by staining, western blot, anti tag coimmunoprecipitation
                (Taliaferro et al., 2011, Rudner et al., 1998, Rudner et al., 1998)
                U2af38 - eIF4E1
                anti bait coimmunoprecipitation, western blot
                (Graham et al., 2011)
                U2af38 - fl(2)d
                anti bait coimmunoprecipitation, western blot
                (Penn et al., 2008)
                Summary of Genetic Interactions
                esyN Network Diagram
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                External Data
                Subunit Structure (UniProtKB)
                Associates with a 65 kDa protein.
                (UniProt, Q94535 )
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                DroID - A comprehensive database of gene and protein interactions.
                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Pathways
                Signaling Pathways (FlyBase)
                Metabolic Pathways
                External Data
                Linkouts
                KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                Genomic Location and Detailed Mapping Data
                Chromosome (arm)
                2L
                Recombination map
                2-0.5
                Cytogenetic map
                21B7-21B8
                Sequence location
                2L:292,959..294,681 [-]
                FlyBase Computed Cytological Location
                Cytogenetic map
                Evidence for location
                21B7-21B8
                Limits computationally determined from genome sequence between P{lacW}spenk06805&P{lacW}l(2)k13604k13604 and P{lacW}U2af38k14504
                Experimentally Determined Cytological Location
                Cytogenetic map
                Notes
                References
                21B7-21B8
                (Rudner, 1996.8.15, BDGP Project Members, 1994-1999)
                21B7-21B8
                (determined by in situ hybridisation)
                (Spradling et al., 1999, Rudner et al., 1996)
                Experimentally Determined Recombination Data
                Location
                2-0.5
                (FlyBase, 2016)
                2-0.0
                (Comeron et al., 2012)
                2-
                (Rudner, 1996.8.15)
                Left of (cM)
                Right of (cM)
                Notes
                Stocks and Reagents
                Stocks (10)
                Genomic Clones (15)
                 

                Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                cDNA Clones (90)
                 

                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                cDNA clones, fully sequences
                BDGP DGC clones
                Other clones
                  Drosophila Genomics Resource Center cDNA clones

                  For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                  cDNA Clones, End Sequenced (ESTs)
                  BDGP DGC clones
                  Other clones
                  RNAi and Array Information
                  Linkouts
                  DRSC - Results frm RNAi screens
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  Antibody Information
                  Laboratory Generated Antibodies
                   
                  Commercially Available Antibodies
                   
                  Other Information
                  Relationship to Other Genes
                  Source for database identify of
                  Source for identity of: U2af38 CG3582
                  (Guan, 1999.11)
                  Source for database merge of
                  Additional comments
                  Other Comments
                  RNAi screen using dsRNA made from templates generated with primers directed against this gene results in a long metaphase spindle with misaligned chromosomes when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.
                  (Goshima et al., 2007)
                  Studies in vivo reveal that the RS domain of U2af38 is completely dispensable: the domain is not necessary for constitutive splicing in vitro. The RS domain is also not required for enhancer-dependent splicing of dsx in vitro.
                  (Rudner et al., 1998)
                  E.coli copurification assay is used to map the domain on U2af50 that interacts with U2af38 : a 28 amino acid fragment is necessary and sufficient for the interaction. Interaction studies in vivo indicate that the U2af50/U2af38 heterodimer is essential for viability in vivo.
                  (Rudner et al., 1998)
                  The presence of one RS domain of U2AF, on either the large subunit (encoded by U2af50) or the small subunit (encoded by U2af38), promotes high-affinity pyrimidine tract RNA binding activity.
                  (Rudner et al., 1998)
                  A U2af38 cDNA has been cloned and sequenced.
                  (Rudner et al., 1996)
                  Origin and Etymology
                  Discoverer
                  Etymology
                  Identification
                  External Crossreferences and Linkouts ( 55 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                  UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                  Other crossreferences
                  BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                  Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                  Flygut - An atlas of the Drosophila adult midgut
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                  InterPro - A database of protein families, domains and functional sites
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  modMine - A data warehouse for the modENCODE project
                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                  Linkouts
                  ApoDroso - Functional genomic database for photoreceptor development, survival and function
                  BioGRID - A database of protein and genetic interactions.
                  DroID - A comprehensive database of gene and protein interactions.
                  DRSC - Results frm RNAi screens
                  FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                  FlyMine - An integrated database for Drosophila genomics
                  InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                  KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                  MIST (protein-protein) - An integrated Molecular Interaction Database
                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                  Synonyms and Secondary IDs (12)
                  Datasets (0)
                  Study focus (0)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  References (81)