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Gene Dmel\Ric

General Information
Symbol	Dmel\Ric	Species	D. melanogaster
Name	Ras which interacts with Calmodulin	Annotation symbol	CG8418
Feature type	protein_coding_gene	FlyBase ID	FBgn0017549
Gene Model Status	Current	Stock availability	7 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map	2-
Cytogenetic map	52E5-52E5	Sequence location	2R:11,994,945..11,997,520 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Ras which interacts with Calmodulin is referred to in FlyBase by the symbol Dmel\Ric (CG8418, FBgn0017549). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: calmodulin binding. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: GTP catabolic process; small GTPase mediated signal transduction. 7 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Small GTP-binding protein domain; Small GTPase superfamily; Small GTPase superfamily, Ras type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 and 18-24 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1637466_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Ric. Gene sequence location is 2R:11994945..11997520.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Cai et al., 2011, Mol. Biol. Cell 22(17): 3231--3241 Sequence features BKN45445 BKN27666 HFA07532
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 52E5-52E5   Limits computationally determined from genome sequence between P{PZ}l(2)0507005070&P{EP}CG8414EP525 and P{EP}spinEP645&P{lacW}spink09905
Experimentally Determined Cytological Location
Cytogenetic map Notes References 52E1-52E11     (Wes, 1996.8.16) 52E-52E   (determined by in situ hybridisation)   (Wes et al., 1996)
Experimentally Determined Recombination Data
Location	2- (Wes, 1996.8.16)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Ric for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Ric-RA FBtr0087254  NM_057863   2281   264 Ric-RB FBtr0300576  NM_001169694   2044   264
Additional Transcript Data & Comments
Reported size (kB)	2.3 (northern blot) (Wes et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Ric-PA   FBpp0086392   30.0   264   8.94     NP_477211   AAF58065 Ric-PB   FBpp0289803   30.0   264   8.94     NP_001163165   ACZ94437
Additional Polypeptide Data & Comments
Reported size (kDa)	264 (aa) (Wes et al., 1996)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Small GTPase superfamily (IPR001806) Small GTP-binding protein domain (IPR005225) Small GTPase superfamily, Ras type (IPR020849)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA540481   AA802065   AE013599 AAF58065   AC004248   AE013599 ACZ94437   AI107963   AI238083   AI295927   AI405934   AY118407 AAM48436   BF498902   BI173375   BI212449   BI234723   BI236375   BI366924   BI368279   BI368847   BI374650   BI375139   BI584915   BI585867   BI587429   BI591998   BI604963   BI617596   BI620883   BI630305   BI631531   BI631664   BI632160   BI635317   CO154489   CO177722   CO178575   CO179089   CO272460   CO281398   CO283562   CO292894   CO293501   CO308489   CO319248   CO323544   CO324432   CO333045   CO336519   CO342027   EC056702   EC064384   EC064449   EC066264   EC075141   EC076323   EC084869   EC195646   EC195885   EC200835   EC201269   EC204403   EC216678   EC226580   EC227246   EC243732   EC247896   EC254230   EC262827   EV593305   Y07564 CAA68849
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8MT34 Q7JMZ0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
	Ric transcripts are expressed throughout development. (Wes et al., 1996)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0017549    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0017549 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 and 18-24 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0017549 expression level Developmental Stage   Expression Level embryo 00-02hr    2009 embryo 02-04hr    540 embryo 04-06hr    356 embryo 06-08hr    453 embryo 08-10hr    530 embryo 10-12hr    671 embryo 12-14hr    726 embryo 14-16hr    443 embryo 16-18hr    626 embryo 18-20hr    761 embryo 20-22hr    1091 embryo 22-24hr    1432 larva L1    1371 larva L2    975 larva L3 12hr old    692 larva L3 puffstage 1-2    641 larva L3 puffstage 3-6    955 larva L3 puffstage 7-9    948 white prepupae new    676 white prepupae 12hr    626 white prepupae 24hr    641 pupae 2d postWPP    1169 pupae 3d postWPP    1393 pupae 4d postWPP    698 adult male 01day    1094 adult male 05day    1232 adult male 30day    1131 adult female 01day    964 adult female 05day    1568 adult female 30day    1449 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2009) embryo 02-04hr  (540) embryo 04-06hr  (356) embryo 06-08hr  (453) embryo 08-10hr  (530) embryo 10-12hr  (671) embryo 12-14hr  (726) embryo 14-16hr  (443) embryo 16-18hr  (626) embryo 18-20hr  (761) embryo 20-22hr  (1091) embryo 22-24hr  (1432) larva L1  (1371) larva L2  (975) larva L3 12hr old  (692) larva L3 puffstage 1-2  (641) larva L3 puffstage 3-6  (955) larva L3 puffstage 7-9  (948) white prepupae new  (676) white prepupae 12hr  (626) white prepupae 24hr  (641) pupae 2d postWPP  (1169) pupae 3d postWPP  (1393) pupae 4d postWPP  (698) adult male 01day  (1094) adult male 05day  (1232) adult male 30day  (1131) adult female 01day  (964) adult female 05day  (1568) adult female 30day  (1449) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2009) embryo 02-04hr    540 embryo 04-06hr    356 embryo 06-08hr    453 embryo 08-10hr    530 embryo 10-12hr    671 embryo 12-14hr    726 embryo 14-16hr    443 embryo 16-18hr    626 embryo 18-20hr    761 embryo 20-22hr    1091 embryo 22-24hr  1432 larva L1    1371 larva L2    975 larva L3 12hr old    692 larva L3 puffstage 1-2    641 larva L3 puffstage 3-6    955 larva L3 puffstage 7-9    948 white prepupae new    676 white prepupae 12hr    626 white prepupae 24hr    641 pupae 2d postWPP    1169 pupae 3d postWPP    1393 pupae 4d postWPP    698 adult male 01day    1094 adult male 05day    1232 adult male 30day    1131 adult female 01day    964 adult female 05day  (1568) adult female 30day  1449 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2009 embryo 02-04hr    540 embryo 04-06hr    356 embryo 06-08hr    453 embryo 08-10hr    530 embryo 10-12hr    671 embryo 12-14hr    726 embryo 14-16hr    443 embryo 16-18hr    626 embryo 18-20hr    761 embryo 20-22hr    1091 embryo 22-24hr    1432 larva L1    1371 larva L2    975 larva L3 12hr old    692 larva L3 puffstage 1-2    641 larva L3 puffstage 3-6    955 larva L3 puffstage 7-9    948 white prepupae new    676 white prepupae 12hr    626 white prepupae 24hr    641 pupae 2d postWPP    1169 pupae 3d postWPP    1393 pupae 4d postWPP    698 adult male 01day    1094 adult male 05day    1232 adult male 30day    1131 adult female 01day    964 adult female 05day    1568 adult female 30day    1449 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2009 embryo 02-04hr    540 embryo 04-06hr    356 embryo 06-08hr    453 embryo 08-10hr    530 embryo 10-12hr    671 embryo 12-14hr    726 embryo 14-16hr    443 embryo 16-18hr    626 embryo 18-20hr    761 embryo 20-22hr    1091 embryo 22-24hr    1432 larva L1    1371 larva L2    975 larva L3 12hr old    692 larva L3 puffstage 1-2    641 larva L3 puffstage 3-6    955 larva L3 puffstage 7-9    948 white prepupae new    676 white prepupae 12hr    626 white prepupae 24hr    641 pupae 2d postWPP    1169 pupae 3d postWPP    1393 pupae 4d postWPP    698 adult male 01day    1094 adult male 05day    1232 adult male 30day    1131 adult female 01day    964 adult female 05day    1568 adult female 30day    1449 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0017549 expression level Developmental Stage   Expression Level embryo 00-02hr    2009 embryo 02-04hr    540 embryo 04-06hr    356 embryo 06-08hr    453 embryo 08-10hr    530 embryo 10-12hr    671 embryo 12-14hr    726 embryo 14-16hr    443 embryo 16-18hr    626 embryo 18-20hr    761 embryo 20-22hr    1091 embryo 22-24hr    1432 larva L1    1371 larva L2    975 larva L3 12hr old    692 larva L3 puffstage 1-2    641 larva L3 puffstage 3-6    955 larva L3 puffstage 7-9    948 white prepupae new    676 white prepupae 12hr    626 white prepupae 24hr    641 pupae 2d postWPP    1169 pupae 3d postWPP    1393 pupae 4d postWPP    698 adult male 01day    1094 adult male 05day    1232 adult male 30day    1131 adult female 01day    964 adult female 05day    1568 adult female 30day    1449 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2009) embryo 02-04hr  (540) embryo 04-06hr  (356) embryo 06-08hr  (453) embryo 08-10hr  (530) embryo 10-12hr  (671) embryo 12-14hr  (726) embryo 14-16hr  (443) embryo 16-18hr  (626) embryo 18-20hr  (761) embryo 20-22hr  (1091) embryo 22-24hr  (1432) larva L1  (1371) larva L2  (975) larva L3 12hr old  (692) larva L3 puffstage 1-2  (641) larva L3 puffstage 3-6  (955) larva L3 puffstage 7-9  (948) white prepupae new  (676) white prepupae 12hr  (626) white prepupae 24hr  (641) pupae 2d postWPP  (1169) pupae 3d postWPP  (1393) pupae 4d postWPP  (698) adult male 01day  (1094) adult male 05day  (1232) adult male 30day  (1131) adult female 01day  (964) adult female 05day  (1568) adult female 30day  (1449) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  2009 embryo 02-04hr    540 embryo 04-06hr    356 embryo 06-08hr    453 embryo 08-10hr    530 embryo 10-12hr    671 embryo 12-14hr    726 embryo 14-16hr    443 embryo 16-18hr    626 embryo 18-20hr    761 embryo 20-22hr    1091 embryo 22-24hr  1432 larva L1    1371 larva L2    975 larva L3 12hr old    692 larva L3 puffstage 1-2    641 larva L3 puffstage 3-6    955 larva L3 puffstage 7-9    948 white prepupae new    676 white prepupae 12hr    626 white prepupae 24hr    641 pupae 2d postWPP    1169 pupae 3d postWPP    1393 pupae 4d postWPP    698 adult male 01day    1094 adult male 05day    1232 adult male 30day    1131 adult female 01day    964 adult female 05day  1568 adult female 30day  1449 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2009 embryo 02-04hr    540 embryo 04-06hr    356 embryo 06-08hr    453 embryo 08-10hr    530 embryo 10-12hr    671 embryo 12-14hr    726 embryo 14-16hr    443 embryo 16-18hr    626 embryo 18-20hr    761 embryo 20-22hr    1091 embryo 22-24hr    1432 larva L1    1371 larva L2    975 larva L3 12hr old    692 larva L3 puffstage 1-2    641 larva L3 puffstage 3-6    955 larva L3 puffstage 7-9    948 white prepupae new    676 white prepupae 12hr    626 white prepupae 24hr    641 pupae 2d postWPP    1169 pupae 3d postWPP    1393 pupae 4d postWPP    698 adult male 01day    1094 adult male 05day    1232 adult male 30day    1131 adult female 01day    964 adult female 05day    1568 adult female 30day    1449 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2009 embryo 02-04hr    540 embryo 04-06hr    356 embryo 06-08hr    453 embryo 08-10hr    530 embryo 10-12hr    671 embryo 12-14hr    726 embryo 14-16hr    443 embryo 16-18hr    626 embryo 18-20hr    761 embryo 20-22hr    1091 embryo 22-24hr    1432 larva L1    1371 larva L2    975 larva L3 12hr old    692 larva L3 puffstage 1-2    641 larva L3 puffstage 3-6    955 larva L3 puffstage 7-9    948 white prepupae new    676 white prepupae 12hr    626 white prepupae 24hr    641 pupae 2d postWPP    1169 pupae 3d postWPP    1393 pupae 4d postWPP    698 adult male 01day    1094 adult male 05day    1232 adult male 30day    1131 adult female 01day    964 adult female 05day    1568 adult female 30day    1449 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0017549    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0017549 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0017549 expression level Tissue   Expression Level Larval Central Nervous System    915.425 Larval Midgut    217.3 Larval Hindgut    349.3 Larval Malpighian Tubules    150.2 Larval Fat Body    125.3 Larval Salivary Gland    256.1 Larval Trachea    400.85 Larval Carcass    410.35 Adult Head    830.8 Adult Eye    720.025 Adult Brain    2170.2 Adult Thoracic-Abdominal Ganglion    1704.4 Adult Crop    649.9 Adult Midgut    174.3 Adult Hindgut    368.6 Adult Malpighian Tubules    102.1 Adult Fat Body    146.8 Adult Salivary Gland    256.8 Adult Heart    351.275 Adult VirginFemale Spermatheca    166 Adult InseminatedFemale Spermatheca    261.8 Adult Ovary    362.8 Adult Testis    61.9 Adult Male Accessory Gland    203.8 Adult Carcass    223.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (915.425) Larval Midgut    217.3 Larval Hindgut    349.3 Larval Malpighian Tubules    150.2 Larval Fat Body    125.3 Larval Salivary Gland    256.1 Larval Trachea    400.85 Larval Carcass    410.35 Adult Head  (830.8) Adult Eye  (720.025) Adult Brain  (2170.2) Adult Thoracic-Abdominal Ganglion  (1704.4) Adult Crop  (649.9) Adult Midgut    174.3 Adult Hindgut    368.6 Adult Malpighian Tubules    102.1 Adult Fat Body    146.8 Adult Salivary Gland    256.8 Adult Heart    351.275 Adult VirginFemale Spermatheca    166 Adult InseminatedFemale Spermatheca    261.8 Adult Ovary    362.8 Adult Testis    61.9 Adult Male Accessory Gland    203.8 Adult Carcass    223.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    915.425 Larval Midgut    217.3 Larval Hindgut    349.3 Larval Malpighian Tubules    150.2 Larval Fat Body    125.3 Larval Salivary Gland    256.1 Larval Trachea    400.85 Larval Carcass    410.35 Adult Head    830.8 Adult Eye    720.025 Adult Brain  (2170.2) Adult Thoracic-Abdominal Ganglion  (1704.4) Adult Crop    649.9 Adult Midgut    174.3 Adult Hindgut    368.6 Adult Malpighian Tubules    102.1 Adult Fat Body    146.8 Adult Salivary Gland    256.8 Adult Heart    351.275 Adult VirginFemale Spermatheca    166 Adult InseminatedFemale Spermatheca    261.8 Adult Ovary    362.8 Adult Testis    61.9 Adult Male Accessory Gland    203.8 Adult Carcass    223.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    915.425 Larval Midgut    217.3 Larval Hindgut    349.3 Larval Malpighian Tubules    150.2 Larval Fat Body    125.3 Larval Salivary Gland    256.1 Larval Trachea    400.85 Larval Carcass    410.35 Adult Head    830.8 Adult Eye    720.025 Adult Brain    2170.2 Adult Thoracic-Abdominal Ganglion    1704.4 Adult Crop    649.9 Adult Midgut    174.3 Adult Hindgut    368.6 Adult Malpighian Tubules    102.1 Adult Fat Body    146.8 Adult Salivary Gland    256.8 Adult Heart    351.275 Adult VirginFemale Spermatheca    166 Adult InseminatedFemale Spermatheca    261.8 Adult Ovary    362.8 Adult Testis    61.9 Adult Male Accessory Gland    203.8 Adult Carcass    223.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0017549 expression level Tissue   Expression Level Larval Central Nervous System    915.425 Larval Midgut    217.3 Larval Hindgut    349.3 Larval Malpighian Tubules    150.2 Larval Fat Body    125.3 Larval Salivary Gland    256.1 Larval Trachea    400.85 Larval Carcass    410.35 Adult Head    830.8 Adult Eye    720.025 Adult Brain    2170.2 Adult Thoracic-Abdominal Ganglion    1704.4 Adult Crop    649.9 Adult Midgut    174.3 Adult Hindgut    368.6 Adult Malpighian Tubules    102.1 Adult Fat Body    146.8 Adult Salivary Gland    256.8 Adult Heart    351.275 Adult VirginFemale Spermatheca    166 Adult InseminatedFemale Spermatheca    261.8 Adult Ovary    362.8 Adult Testis    61.9 Adult Male Accessory Gland    203.8 Adult Carcass    223.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (915.425) Larval Midgut    217.3 Larval Hindgut    349.3 Larval Malpighian Tubules    150.2 Larval Fat Body    125.3 Larval Salivary Gland    256.1 Larval Trachea    400.85 Larval Carcass    410.35 Adult Head  (830.8) Adult Eye  720.025 Adult Brain  (2170.2) Adult Thoracic-Abdominal Ganglion  (1704.4) Adult Crop  649.9 Adult Midgut    174.3 Adult Hindgut    368.6 Adult Malpighian Tubules    102.1 Adult Fat Body    146.8 Adult Salivary Gland    256.8 Adult Heart    351.275 Adult VirginFemale Spermatheca    166 Adult InseminatedFemale Spermatheca    261.8 Adult Ovary    362.8 Adult Testis    61.9 Adult Male Accessory Gland    203.8 Adult Carcass    223.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    915.425 Larval Midgut    217.3 Larval Hindgut    349.3 Larval Malpighian Tubules    150.2 Larval Fat Body    125.3 Larval Salivary Gland    256.1 Larval Trachea    400.85 Larval Carcass    410.35 Adult Head    830.8 Adult Eye    720.025 Adult Brain  (2170.2) Adult Thoracic-Abdominal Ganglion  1704.4 Adult Crop    649.9 Adult Midgut    174.3 Adult Hindgut    368.6 Adult Malpighian Tubules    102.1 Adult Fat Body    146.8 Adult Salivary Gland    256.8 Adult Heart    351.275 Adult VirginFemale Spermatheca    166 Adult InseminatedFemale Spermatheca    261.8 Adult Ovary    362.8 Adult Testis    61.9 Adult Male Accessory Gland    203.8 Adult Carcass    223.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    915.425 Larval Midgut    217.3 Larval Hindgut    349.3 Larval Malpighian Tubules    150.2 Larval Fat Body    125.3 Larval Salivary Gland    256.1 Larval Trachea    400.85 Larval Carcass    410.35 Adult Head    830.8 Adult Eye    720.025 Adult Brain    2170.2 Adult Thoracic-Abdominal Ganglion    1704.4 Adult Crop    649.9 Adult Midgut    174.3 Adult Hindgut    368.6 Adult Malpighian Tubules    102.1 Adult Fat Body    146.8 Adult Salivary Gland    256.8 Adult Heart    351.275 Adult VirginFemale Spermatheca    166 Adult InseminatedFemale Spermatheca    261.8 Adult Ovary    362.8 Adult Testis    61.9 Adult Male Accessory Gland    203.8 Adult Carcass    223.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    830.8   NA  Eye    720.025   NA  Brain    2170.2   915.425  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1704.4   NA  Crop    649.9   217.3  Midgut    174.3   349.3  Hindgut    368.6   150.2  Malpighian Tubules    102.1   125.3  Fat Body    146.8   256.1  Salivary Gland    256.8   NA  Heart    351.275   400.85  Trachea    NA   NA  VirginFemale Spermatheca    166   NA  InseminatedFemale Spermatheca    261.8   NA  Ovary    362.8   NA  Testis    61.9   NA  Male Accessory Gland    203.8   410.35  Carcass    223.8 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_26
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0017549 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8418-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Ric Stages(s) 1-3
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 RicGD13919 Phenotype manifest in Allele
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of Ric Class Mutagen Stocks Known lesion Ric5-HA-1205 1 -- RicDG30401 P-element activity 1 -- RicG2693 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Ric Class Mutagen Stocks Known lesion RicGD13919 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes RicJF02670 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes RicKK107666 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes RicninaE.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel7139 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD13919} NA P{KK107666} NA P{TRiP.JF02670} NA characterization construct P{MycRic} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{RS5}Ric5-HA-1205 NA P{wHy}RicDG30401a NA P{wHy}RicDG30401b NA insertion of mobile activating element P{EP}RicG2693 NA
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function
CV term Evidence References
calmodulin binding inferred from direct assay (Wes et al., 1996)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
calmodulin binding inferred from sequence or structural similarity with UniProtKB:Q99578 (FlyBase, 1992-) non-traceable author statement (Wes, 1996.8.16) traceable author statement (Montell, 1999) GTPase activity inferred from sequence or structural similarity with Ras85D (Wes et al., 1996) GTP binding inferred from sequence or structural similarity with UniProtKB:Q99578 (FlyBase, 1992-)
Biological Process
CV term Evidence References
GTP catabolic process inferred from electronic annotation with InterPro:IPR020849 (FlyBase Curators et al., 2004-) small GTPase mediated signal transduction inferred from electronic annotation with InterPro:IPR001806 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
plasma membrane inferred from sequence or structural similarity with UniProtKB:Q99578 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Ric allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62501 DroID - A comprehensive database of gene and protein interactions. • FBgn0017549 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36776
Orthologs
Genome-wide drosophilid orthologs	Dana\GF13570 Dere\GG22302 Dgri\GH19819 Dmoj\GI20407 Dper\GL19979 Dpse\GA21063 Dsec\GM20091 Dsim\GD25569 Dvir\GJ20079 Dyak\GE14098
Curated drosophilid orthologs	Dpse\GA21063
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL009180-PA Aedes aegypti (mosquito) AGAP005159-PA Anopheles gambiae (mosquito) XP_395139.1 Apis mellifera (honey bee) ENSBTAP00000000114 Bos taurus (bovine) ENSCAFP00000024867 Canis familiaris (dog) CPIJ014248 Culex pipens (mosquito) ENSCPOP00000008399 Cavia porcellus (guinea pig) 158614 Capitella spl (polychaete worm) ENSDARP00000091195 Danio rerio (zebra fish) ENSECAP00000014236 Equus caballus (horse) ENSGALP00000028236 Gallus gallus (chicken) ENSP00000321805 Homo sapiens (human) ENSMODP00000037111 Monodelphis domestica (gray opossum) ENSMMUP00000016378 Macaca mulatta (rhesus monkey) ENSMUSP00000080724 Mus musculus (house mouse) 235524 Nematostella vectensis (starlet anemone) XP_001601283.1 Nasonia vitripennis (wasp) ENSOANP00000004375 Ornithorynchus anatinus (platypus) PHUM004804-PA Pediculus humanus (human body louse) ENSPPYP00000010248 Pongo pygmaeus (orangutan) ENSPTRP00000016975 Pan troglodytes (chimpanzee) ENSRNOP00000023871 Rattus norvegicus (norway rat) XP_783565.1 Strongylocentrotus purpuratus (purple sea urchin) 30838 Trichoplax adhaerens (metazoa) XP_969125.1 Tribolium castaneum (red flour beetle) ENSXETP00000027187 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14814 LH17314 ISCW018486 FBgn0231723 FBgn0207220 FBgn0196855 FBgn0174974 FBgn0081051 FBgn0157576 FBgn0143143 FBgn0127283 FBgn0114474 FBgn0090599 CPIJ014248 BGIBMGA003980 GB11636 AGAP005159 AAEL015232 AAEL009180 PHUM377660 GLEAN_08717
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	27520 y1 v1; P{TRiP.JF02670}attP2 27003 y1 w*; P{EP}RicG2693 21317 y1 w67c23; P{wHy}RicDG30401a
Kyoto	125140 w1118; P{RS5}Ric5-HA-1205
VDRC	v104782 P{KK107666}VIE-260B v35930 w1118 P{GD13919}v35930 v35929 w1118; P{GD13919}v35929/CyO
Genomic Clones ( 2 )
	BACR04O19 BACR29I14 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 63 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE62293
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT13318 GH05872 GH14071 GH26087 GM03803 LD19979 LP09693 RE16279 RE17544 RE30471 RE32425 RE52565 RE54225 RE54895 RE62875 RH09580 RH24243 RH25560 RH28106 RH47975 RH52136 RH59319 RH61120 RH61286 RH70471 SD16626 SD25775
Other clones	8530 42412 66014 72457 73786 82204 83098 97368 103136 154222 155645 173149 214415.67 280682 523749 CK01.67B.G7 CK01.74A.F10 CK01.111C.D7 Dmel_neb_013993_0699_2564 EK054128 EK057107 EK058353 EK107241 EK157044 EK163652 EK190802 EK193647 EK201153 EK203140 EK258457 EK277434 EK305529 EN04230 EN12708 EP13648
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0017549 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36776
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Ric, a gene encoding a calmodulin-binding Ras-related GTPase, is molecularly characterised. 20 residues, amino acids 242 to 261, are necessary and sufficient to bind calmodulin in an overlay. (Wes et al., 1996)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057863 NM_001169694 RefSeq (Proteins) • NP_477211 NP_001163165 DDBJ / EMBL / GenBank • AAF58065 AAM48436 AC004248 ACZ94437 AY118407 BI374650 CAA68849 Y07564 Entrez Gene - A searchable database of RefSeq genes. • 36776 UniProtKB/TrEMBL • Q7JMZ0 Q8MT34
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Small GTPase superfamily (IPR001806) Small GTP-binding protein domain (IPR005225) Small GTPase superfamily, Ras type (IPR020849)
Linkouts
	BioGRID - A database of protein and genetic interactions • 62501 DroID - A comprehensive database of gene and protein interactions. • FBgn0017549 DRSC - Results from RNAi screens. • FBgn0017549 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0017549 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8418-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0017549 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36776 InParanoid A subset of ortholog calls from InParanoid. • AAEL009180-PA Aedes aegypti (mosquito) AGAP005159-PA Anopheles gambiae (mosquito) XP_395139.1 Apis mellifera (honey bee) ENSBTAP00000000114 Bos taurus (bovine) ENSCAFP00000024867 Canis familiaris (dog) CPIJ014248 Culex pipens (mosquito) ENSCPOP00000008399 Cavia porcellus (guinea pig) 158614 Capitella spl (polychaete worm) ENSDARP00000091195 Danio rerio (zebra fish) ENSECAP00000014236 Equus caballus (horse) ENSGALP00000028236 Gallus gallus (chicken) ENSP00000321805 Homo sapiens (human) ENSMODP00000037111 Monodelphis domestica (gray opossum) ENSMMUP00000016378 Macaca mulatta (rhesus monkey) ENSMUSP00000080724 Mus musculus (house mouse) 235524 Nematostella vectensis (starlet anemone) XP_001601283.1 Nasonia vitripennis (wasp) ENSOANP00000004375 Ornithorynchus anatinus (platypus) PHUM004804-PA Pediculus humanus (human body louse) ENSPPYP00000010248 Pongo pygmaeus (orangutan) ENSPTRP00000016975 Pan troglodytes (chimpanzee) ENSRNOP00000023871 Rattus norvegicus (norway rat) XP_783565.1 Strongylocentrotus purpuratus (purple sea urchin) 30838 Trichoplax adhaerens (metazoa) XP_969125.1 Tribolium castaneum (red flour beetle) ENSXETP00000027187 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36776 modMine - Data generated by the modENCODE project. • FBgn0017549 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14814 LH17314 ISCW018486 FBgn0231723 FBgn0207220 FBgn0196855 FBgn0174974 FBgn0081051 FBgn0157576 FBgn0143143 FBgn0127283 FBgn0114474 FBgn0090599 CPIJ014248 BGIBMGA003980 GB11636 AGAP005159 AAEL015232 AAEL009180 PHUM377660 GLEAN_08717
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	CG8418 (Keleman et al., 2009.8.5, Perkins et al., 2009) RIC (Harrison et al., 2005, Montell, 1999, Wes et al., 1996, Harrison et al., 2006) Ric (Harrison et al., 2005, Robida et al., 2007)
Name Synonym	Ras-related which interacted with Calmodulin (Wes et al., 1996) Ras which interacts with Calmodulin
Secondary FlyBase IDs
References ( 29 )
Generate a list of	All references relating to this gene ( 29 )
List References by type	Research paper  ( 6 ) Supplementary material  ( 3 ) Review  ( 1 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 4 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 2 )
	Cai et al., 2011, Mol. Biol. Cell 22(17): 3231--3241 An evolutionarily conserved Rit GTPase-p38 MAPK signaling pathway mediates oxidative stress resistance. [FBrf0215020] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...