a novel signaling protein that prevents cyclin degredation in G2 by interacting with Fizzy-related - inhibits Fizzy-related's activation of protein degradation machinery - mutants exhibit premature cyclin destruction
Gene model reviewed during 5.52
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Rca1 using the Feature Mapper tool.
Rca1 transcripts are abundant and uniformly distributed in early embryos prior to cellularization. During germ band elongation in stages 8 and 9, transcripts are detected predominantly in the mesoderm and in the anterior and posterior midgut primordia. In stages 10 and 11, high levels of Rca1 transcript are observed throughout the embryo but not in the amnioserosa. By stage 13, staining is mainly restricted to the cells of the developing CNS. Weak expression is also observed in the midgut
GBrowse - Visual display of RNA-Seq signalsView Dmel\Rca1 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Rca1 CG10800
RNAi screen using dsRNA made from templates generated with primers directed against this gene results in aberrantly long spindles when assayed in S2 cells in the presence of Cdc27 dsRNA. This phenotype cannot be observed when the screen is performed without Cdc27 dsRNA.
numb functions downstream of cell division genes (CycA, Rca1 and stg) and progression through the cell cycle is required for asymmetric localisation of numb and thus N mediated specification of the sib fate in the RP2/sib division.