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Gene Dmel\Mcm5

General Information
Symbol	Dmel\Mcm5	Species	D. melanogaster
Name	Minichromosome maintenance 5	Annotation symbol	CG4082
Feature type	protein_coding_gene	FlyBase ID	FBgn0017577
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	DmMcm5
Genomic Location
Chromosome (arm)	3R	Recombination map	3-
Cytogenetic map	86C6-86C6	Sequence location	3R:6,614,250..6,616,872 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Minichromosome maintenance 5 is referred to in FlyBase by the symbol Dmel\Mcm5 (CG4082, FBgn0017577). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: 3'-5' DNA helicase activity. There is experimental evidence that it is involved in the biological process: meiosis; resolution of meiotic recombination intermediates; chromosome condensation; DNA endoreduplication. 21 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; nuclear chromosome; imaginal disc. It has one annotated transcript and one annotated polypeptide. Protein features are: ATPase, AAA+ type, core; Mini-chromosome maintenance complex protein 5; Mini-chromosome maintenance, DNA-dependent ATPase; Mini-chromosome maintenance, conserved site; Nucleic acid-binding, OB-fold; Nucleic acid-binding, OB-fold-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval salivary gland, larval trachea. Comments on Affy2 ProbeSet: ProbeSet 1626647_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Mcm5. Gene sequence location is 3R:6614250..6616872.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features BKN21634 HFA16735
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 86C6-86C6   Limits computationally determined from genome sequence between P{PZ}hth05745 and P{EP}EP3340EP3340
Experimentally Determined Cytological Location
Cytogenetic map Notes References 86C1-86C15     (Su, 1996.12.31)
Experimentally Determined Recombination Data
Location	3- (Su, 1996.12.31)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Mcm5 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Mcm5-RA FBtr0082279  NM_079584   2448   733
Additional Transcript Data & Comments
Reported size (kB)	2.2 (longest cDNA) (Su et al., 1997)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Mcm5-PA   FBpp0081756   82.3   733   7.91     NP_524308   AAF54557
Additional Polypeptide Data & Comments
Reported size (kDa)	732 (aa) (Su et al., 1997)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Mini-chromosome maintenance, conserved site (IPR018525) Mini-chromosome maintenance, DNA-dependent ATPase (IPR001208) Mini-chromosome maintenance complex protein 5 (IPR008048) ATPase, AAA+ type, core (IPR003593) Nucleic acid-binding, OB-fold (IPR012340) Nucleic acid-binding, OB-fold-like (IPR016027)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201450   AA246484   AA246891   AA264302   AA264669   AA540414   AA541234   AA820142   AA942442   AA949520   AA978465   AA979111   AE014297 AAF54557   AI405933   AI455741   AI456250   AI456432   AI456655   AI456666   AI516512   AI516574   AI518066   AI519762   AY071628 AAL49250   BG639045   BI167193   BI237636   BI239475   BI241767   BI241840   BI242674   BI351995   BI362576   BI363670   BI369366   BI371130   BI482788   BI483662   BI483816   BI484482   BI486567   BI578444   BI580071   BI635659   BI635941   BP542473   BP556684   BP556685   BQ103420   CO285311   CO320783   EC052731   EC073843   EC204722   EC227701   EV575431   EV579120   GH749544   GH755061   GH757280   GH758748   GH772546   GH799840   GH799889   GH811870   GH817520   GH827676   GH829426   GH830652   GH835513   GH854613   GH857955   GH884721   GH894676   GH896817   GH897116   GH900292   GH901072   GH904567   GH916223   GH917870   GH930310   GH930631   U83493 AAC47652
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VGW6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0017577    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0017577 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0017577 expression level Developmental Stage   Expression Level embryo 00-02hr    12066 embryo 02-04hr    5457 embryo 04-06hr    13513 embryo 06-08hr    8587 embryo 08-10hr    5266 embryo 10-12hr    3131 embryo 12-14hr    1574 embryo 14-16hr    931 embryo 16-18hr    465 embryo 18-20hr    269 embryo 20-22hr    230 embryo 22-24hr    277 larva L1    970 larva L2    827 larva L3 12hr old    594 larva L3 puffstage 1-2    720 larva L3 puffstage 3-6    918 larva L3 puffstage 7-9    957 white prepupae new    991 white prepupae 12hr    1470 white prepupae 24hr    971 pupae 2d postWPP    234 pupae 3d postWPP    125 pupae 4d postWPP    318 adult male 01day    104 adult male 05day    111 adult male 30day    140 adult female 01day    2785 adult female 05day    6065 adult female 30day    5977 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (12066) embryo 02-04hr  (5457) embryo 04-06hr  (13513) embryo 06-08hr  (8587) embryo 08-10hr  (5266) embryo 10-12hr  (3131) embryo 12-14hr  (1574) embryo 14-16hr  (931) embryo 16-18hr  (465) embryo 18-20hr  (269) embryo 20-22hr  (230) embryo 22-24hr  (277) larva L1  (970) larva L2  (827) larva L3 12hr old  (594) larva L3 puffstage 1-2  (720) larva L3 puffstage 3-6  (918) larva L3 puffstage 7-9  (957) white prepupae new  (991) white prepupae 12hr  (1470) white prepupae 24hr  (971) pupae 2d postWPP  (234) pupae 3d postWPP  (125) pupae 4d postWPP  (318) adult male 01day  104 adult male 05day  (111) adult male 30day  (140) adult female 01day  (2785) adult female 05day  (6065) adult female 30day  (5977) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (12066) embryo 02-04hr  (5457) embryo 04-06hr  (13513) embryo 06-08hr  (8587) embryo 08-10hr  (5266) embryo 10-12hr  (3131) embryo 12-14hr  (1574) embryo 14-16hr    931 embryo 16-18hr    465 embryo 18-20hr    269 embryo 20-22hr    230 embryo 22-24hr    277 larva L1    970 larva L2    827 larva L3 12hr old    594 larva L3 puffstage 1-2    720 larva L3 puffstage 3-6    918 larva L3 puffstage 7-9    957 white prepupae new    991 white prepupae 12hr  1470 white prepupae 24hr    971 pupae 2d postWPP    234 pupae 3d postWPP    125 pupae 4d postWPP    318 adult male 01day    104 adult male 05day    111 adult male 30day    140 adult female 01day  (2785) adult female 05day  (6065) adult female 30day  (5977) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (12066) embryo 02-04hr    5457 embryo 04-06hr  (13513) embryo 06-08hr    8587 embryo 08-10hr    5266 embryo 10-12hr    3131 embryo 12-14hr    1574 embryo 14-16hr    931 embryo 16-18hr    465 embryo 18-20hr    269 embryo 20-22hr    230 embryo 22-24hr    277 larva L1    970 larva L2    827 larva L3 12hr old    594 larva L3 puffstage 1-2    720 larva L3 puffstage 3-6    918 larva L3 puffstage 7-9    957 white prepupae new    991 white prepupae 12hr    1470 white prepupae 24hr    971 pupae 2d postWPP    234 pupae 3d postWPP    125 pupae 4d postWPP    318 adult male 01day    104 adult male 05day    111 adult male 30day    140 adult female 01day    2785 adult female 05day    6065 adult female 30day    5977 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    12066 embryo 02-04hr    5457 embryo 04-06hr    13513 embryo 06-08hr    8587 embryo 08-10hr    5266 embryo 10-12hr    3131 embryo 12-14hr    1574 embryo 14-16hr    931 embryo 16-18hr    465 embryo 18-20hr    269 embryo 20-22hr    230 embryo 22-24hr    277 larva L1    970 larva L2    827 larva L3 12hr old    594 larva L3 puffstage 1-2    720 larva L3 puffstage 3-6    918 larva L3 puffstage 7-9    957 white prepupae new    991 white prepupae 12hr    1470 white prepupae 24hr    971 pupae 2d postWPP    234 pupae 3d postWPP    125 pupae 4d postWPP    318 adult male 01day    104 adult male 05day    111 adult male 30day    140 adult female 01day    2785 adult female 05day    6065 adult female 30day    5977 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0017577 expression level Developmental Stage   Expression Level embryo 00-02hr    12066 embryo 02-04hr    5457 embryo 04-06hr    13513 embryo 06-08hr    8587 embryo 08-10hr    5266 embryo 10-12hr    3131 embryo 12-14hr    1574 embryo 14-16hr    931 embryo 16-18hr    465 embryo 18-20hr    269 embryo 20-22hr    230 embryo 22-24hr    277 larva L1    970 larva L2    827 larva L3 12hr old    594 larva L3 puffstage 1-2    720 larva L3 puffstage 3-6    918 larva L3 puffstage 7-9    957 white prepupae new    991 white prepupae 12hr    1470 white prepupae 24hr    971 pupae 2d postWPP    234 pupae 3d postWPP    125 pupae 4d postWPP    318 adult male 01day    104 adult male 05day    111 adult male 30day    140 adult female 01day    2785 adult female 05day    6065 adult female 30day    5977 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (12066) embryo 02-04hr  (5457) embryo 04-06hr  (13513) embryo 06-08hr  (8587) embryo 08-10hr  (5266) embryo 10-12hr  (3131) embryo 12-14hr  (1574) embryo 14-16hr  (931) embryo 16-18hr  (465) embryo 18-20hr  (269) embryo 20-22hr  (230) embryo 22-24hr  (277) larva L1  (970) larva L2  (827) larva L3 12hr old  (594) larva L3 puffstage 1-2  (720) larva L3 puffstage 3-6  (918) larva L3 puffstage 7-9  (957) white prepupae new  (991) white prepupae 12hr  (1470) white prepupae 24hr  (971) pupae 2d postWPP  (234) pupae 3d postWPP  125 pupae 4d postWPP  (318) adult male 01day  104 adult male 05day  111 adult male 30day  140 adult female 01day  (2785) adult female 05day  (6065) adult female 30day  (5977) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (12066) embryo 02-04hr  (5457) embryo 04-06hr  (13513) embryo 06-08hr  (8587) embryo 08-10hr  (5266) embryo 10-12hr  (3131) embryo 12-14hr  1574 embryo 14-16hr    931 embryo 16-18hr    465 embryo 18-20hr    269 embryo 20-22hr    230 embryo 22-24hr    277 larva L1    970 larva L2    827 larva L3 12hr old    594 larva L3 puffstage 1-2    720 larva L3 puffstage 3-6    918 larva L3 puffstage 7-9    957 white prepupae new    991 white prepupae 12hr  1470 white prepupae 24hr    971 pupae 2d postWPP    234 pupae 3d postWPP    125 pupae 4d postWPP    318 adult male 01day    104 adult male 05day    111 adult male 30day    140 adult female 01day  (2785) adult female 05day  (6065) adult female 30day  (5977) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  12066 embryo 02-04hr    5457 embryo 04-06hr  13513 embryo 06-08hr    8587 embryo 08-10hr    5266 embryo 10-12hr    3131 embryo 12-14hr    1574 embryo 14-16hr    931 embryo 16-18hr    465 embryo 18-20hr    269 embryo 20-22hr    230 embryo 22-24hr    277 larva L1    970 larva L2    827 larva L3 12hr old    594 larva L3 puffstage 1-2    720 larva L3 puffstage 3-6    918 larva L3 puffstage 7-9    957 white prepupae new    991 white prepupae 12hr    1470 white prepupae 24hr    971 pupae 2d postWPP    234 pupae 3d postWPP    125 pupae 4d postWPP    318 adult male 01day    104 adult male 05day    111 adult male 30day    140 adult female 01day    2785 adult female 05day    6065 adult female 30day    5977 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    12066 embryo 02-04hr    5457 embryo 04-06hr    13513 embryo 06-08hr    8587 embryo 08-10hr    5266 embryo 10-12hr    3131 embryo 12-14hr    1574 embryo 14-16hr    931 embryo 16-18hr    465 embryo 18-20hr    269 embryo 20-22hr    230 embryo 22-24hr    277 larva L1    970 larva L2    827 larva L3 12hr old    594 larva L3 puffstage 1-2    720 larva L3 puffstage 3-6    918 larva L3 puffstage 7-9    957 white prepupae new    991 white prepupae 12hr    1470 white prepupae 24hr    971 pupae 2d postWPP    234 pupae 3d postWPP    125 pupae 4d postWPP    318 adult male 01day    104 adult male 05day    111 adult male 30day    140 adult female 01day    2785 adult female 05day    6065 adult female 30day    5977 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0017577    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0017577 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval salivary gland, larval trachea. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0017577 expression level Tissue   Expression Level Larval Central Nervous System    447.85 Larval Midgut no informative data Larval Hindgut    48.6 Larval Malpighian Tubules    6.1 Larval Fat Body    31 Larval Salivary Gland    145.2 Larval Trachea    117.55 Larval Carcass    83.95 Adult Head no informative data Adult Eye    4.3 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion    7.8 Adult Crop no informative data Adult Midgut    17.9 Adult Hindgut no informative data Adult Malpighian Tubules    8.7 Adult Fat Body no informative data Adult Salivary Gland    8.1 Adult Heart    28.525 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    9.2 Adult Ovary    839 Adult Testis    20 Adult Male Accessory Gland    4.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    447.85 Larval Midgut no informative data Larval Hindgut    48.6 Larval Malpighian Tubules    6.1 Larval Fat Body    31 Larval Salivary Gland    145.2 Larval Trachea    117.55 Larval Carcass    83.95 Adult Head no informative data Adult Eye    4.3 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion    7.8 Adult Crop no informative data Adult Midgut    17.9 Adult Hindgut no informative data Adult Malpighian Tubules    8.7 Adult Fat Body no informative data Adult Salivary Gland    8.1 Adult Heart    28.525 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    9.2 Adult Ovary  (839) Adult Testis    20 Adult Male Accessory Gland    4.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    447.85 Larval Midgut no informative data Larval Hindgut    48.6 Larval Malpighian Tubules    6.1 Larval Fat Body    31 Larval Salivary Gland    145.2 Larval Trachea    117.55 Larval Carcass    83.95 Adult Head no informative data Adult Eye    4.3 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion    7.8 Adult Crop no informative data Adult Midgut    17.9 Adult Hindgut no informative data Adult Malpighian Tubules    8.7 Adult Fat Body no informative data Adult Salivary Gland    8.1 Adult Heart    28.525 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    9.2 Adult Ovary    839 Adult Testis    20 Adult Male Accessory Gland    4.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    447.85 Larval Midgut no informative data Larval Hindgut    48.6 Larval Malpighian Tubules    6.1 Larval Fat Body    31 Larval Salivary Gland    145.2 Larval Trachea    117.55 Larval Carcass    83.95 Adult Head no informative data Adult Eye    4.3 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion    7.8 Adult Crop no informative data Adult Midgut    17.9 Adult Hindgut no informative data Adult Malpighian Tubules    8.7 Adult Fat Body no informative data Adult Salivary Gland    8.1 Adult Heart    28.525 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    9.2 Adult Ovary    839 Adult Testis    20 Adult Male Accessory Gland    4.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0017577 expression level Tissue   Expression Level Larval Central Nervous System    447.85 Larval Midgut no informative data Larval Hindgut    48.6 Larval Malpighian Tubules    6.1 Larval Fat Body    31 Larval Salivary Gland    145.2 Larval Trachea    117.55 Larval Carcass    83.95 Adult Head no informative data Adult Eye    4.3 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion    7.8 Adult Crop no informative data Adult Midgut    17.9 Adult Hindgut no informative data Adult Malpighian Tubules    8.7 Adult Fat Body no informative data Adult Salivary Gland    8.1 Adult Heart    28.525 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    9.2 Adult Ovary    839 Adult Testis    20 Adult Male Accessory Gland    4.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    447.85 Larval Midgut no informative data Larval Hindgut    48.6 Larval Malpighian Tubules    6.1 Larval Fat Body    31 Larval Salivary Gland    145.2 Larval Trachea    117.55 Larval Carcass    83.95 Adult Head no informative data Adult Eye    4.3 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion    7.8 Adult Crop no informative data Adult Midgut    17.9 Adult Hindgut no informative data Adult Malpighian Tubules    8.7 Adult Fat Body no informative data Adult Salivary Gland    8.1 Adult Heart    28.525 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    9.2 Adult Ovary  (839) Adult Testis    20 Adult Male Accessory Gland    4.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    447.85 Larval Midgut no informative data Larval Hindgut    48.6 Larval Malpighian Tubules    6.1 Larval Fat Body    31 Larval Salivary Gland    145.2 Larval Trachea    117.55 Larval Carcass    83.95 Adult Head no informative data Adult Eye    4.3 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion    7.8 Adult Crop no informative data Adult Midgut    17.9 Adult Hindgut no informative data Adult Malpighian Tubules    8.7 Adult Fat Body no informative data Adult Salivary Gland    8.1 Adult Heart    28.525 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    9.2 Adult Ovary    839 Adult Testis    20 Adult Male Accessory Gland    4.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    447.85 Larval Midgut no informative data Larval Hindgut    48.6 Larval Malpighian Tubules    6.1 Larval Fat Body    31 Larval Salivary Gland    145.2 Larval Trachea    117.55 Larval Carcass    83.95 Adult Head no informative data Adult Eye    4.3 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion    7.8 Adult Crop no informative data Adult Midgut    17.9 Adult Hindgut no informative data Adult Malpighian Tubules    8.7 Adult Fat Body no informative data Adult Salivary Gland    8.1 Adult Heart    28.525 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    9.2 Adult Ovary    839 Adult Testis    20 Adult Male Accessory Gland    4.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head no informative data Adult Eye     Adult Brain no informative data Adult Thoracic-Abdominal Ganglion     Adult Crop no informative data Adult Midgut     Adult Hindgut no informative data Adult Malpighian Tubules     Adult Fat Body no informative data Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    4.3   NA  Brain    no informative data   447.85  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    7.8   NA  Crop    no informative data   no informative data  Midgut    17.9   48.6  Hindgut    no informative data   6.1  Malpighian Tubules    8.7   31  Fat Body    no informative data   145.2  Salivary Gland    8.1   NA  Heart    28.525   117.55  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    9.2   NA  Ovary    839   NA  Testis    20   NA  Male Accessory Gland    4.8   83.95  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_13
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0017577 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4082-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Mcm5 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal (with Df(3R)BSC38) Mcm5exc222 lethal (with Df(3R)Exel6159) Mcm5exc222 lethal (with Df(3R)Exel7305) Mcm5exc222 lethal | recessive Mcm5exc222 viable Mcm5A7 viable, with Scer\GAL4pnr-MD237 Mcm5GD4229 viable (with Df(3R)BSC38) Mcm5Z3-0852 Mcm5Z3-1138 Mcm5Z3-1334 Mcm5Z3-2022 Mcm5Z3-2146 Mcm5Z3-2156 Mcm5Z3-3224 Mcm5Z3-3278 Mcm5Z3-4809 Mcm5Z3-5239 Mcm5Z3-5602 Mcm5Z3-PMM-0153 Mcm5Z3-PMM-0509 Sterility Allele fertile Mcm5A7 Other Phenotypes Allele meiotic cell cycle defective Mcm5A7 meiotic cell cycle defective (with Df(3R)BSC38) Mcm5A7 meiotic cell cycle defective (with Df(3R)Exel6159) Mcm5A7 meiotic cell cycle defective (with Df(3R)Exel7305) Mcm5A7 visible, with Scer\GAL4pnr-MD237 Mcm5GD4229 Phenotype manifest in Allele imaginal disc Mcm5exc222 nuclear chromosome Mcm5dsRNA.cCa trichogen cell, with Scer\GAL4pnr-MD237 Mcm5GD4229
Classical Alleles ( 16 )
For All Classical Alleles Show
Allele of Mcm5 Class Mutagen Stocks Known lesion Mcm5DG12108 1 -- Mcm5A7 ethyl methanesulfonate 0 Yes Mcm5exc222 Delta2-3 0 Yes Mcm5Z3-0852 0 Yes Mcm5Z3-1138 0 Yes Mcm5Z3-1334 0 Yes Mcm5Z3-2022 0 Yes Mcm5Z3-2146 0 Yes Mcm5Z3-2156 0 Yes Mcm5Z3-3224 0 Yes Mcm5Z3-3278 0 Yes Mcm5Z3-4809 0 Yes Mcm5Z3-5239 0 Yes Mcm5Z3-5602 0 Yes Mcm5Z3-PMM-0153 0 Yes Mcm5Z3-PMM-0509 0 Yes
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Mcm5 Class Mutagen Stocks Known lesion Mcm5GD4229 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Mcm5GLV21044 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Mcm5KK101583 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Mcm5+t4 in vitro construct - genomic fragment 0 Yes Mcm5dsRNA.cCa in vitro construct - RNAi 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)BSC38 (Lake et al., 2007) Df(3R)Exel6159 (Ryder, 2004.4.26, Lake et al., 2007) Df(3R)Exel7305 (Ryder, 2004.4.26, Lake et al., 2007)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4229} NA P{KK101583} NA P{TRiP.GLV21044} NA characterization construct P{Mcm5+t4} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{wHy}Mcm5DG12108 NA
Gene Ontology: Function, Process & Cellular Component ( 11 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function
CV term Evidence References
contributes_to 3'-5' DNA helicase activity inferred from direct assay (Moyer et al., 2006)
Biological Process
CV term Evidence References
chromosome condensation inferred from mutant phenotype (Christensen and Tye, 2003) DNA endoreduplication inferred from mutant phenotype (Park and Asano, 2008) meiosis inferred from mutant phenotype (Page et al., 2007) resolution of meiotic recombination intermediates inferred from mutant phenotype (Lake et al., 2007)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR001208, InterPro:IPR008048, InterPro:IPR018525 (FlyBase Curators et al., 2004-) chromatin binding inferred from sequence or structural similarity with UniProtKB:P55862 (FlyBase, 1992-) DNA binding inferred from electronic annotation with InterPro:IPR001208, InterPro:IPR008048, InterPro:IPR018525 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
DNA-dependent DNA replication initiation inferred from electronic annotation with InterPro:IPR008048 (FlyBase Curators et al., 2004-) pre-replicative complex assembly inferred from sequence or structural similarity with UniProtKB:P55862 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
pre-replicative complex inferred from sequence or structural similarity with UniProtKB:P55862 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Mcm5 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66440 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0017577 DroID - A comprehensive database of gene and protein interactions. • FBgn0017577 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41296
Orthologs
Genome-wide drosophilid orthologs	Dana\GF17903 Dere\GG17694 Dgri\GH18059 Dmoj\GI23737 Dper\GL21915 Dpse\GA17943 Dsec\GM23897 Dsim\GD18709 Dvir\GJ10583 Dwil\GK13898 Dyak\GE26049
Curated drosophilid orthologs	Dpse\GA17943
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL002810-PA Aedes aegypti (mosquito) AGAP004408-PA Anopheles gambiae (mosquito) XP_624292.1 Apis mellifera (honey bee) XP_001950445.1 Acyrthosiphon pisum (pea aphid) At2g07690.1 Arabidopsis thaliana (wall cress) 13316 Batrachochytrium dendrobatidis (chytrid fungus) 120523 Branchiostoma floridae (lancelet) 121597 Branchiostoma floridae (lancelet) XP_001896354.1 Brugia malayi (roundworm nematode) BGIBMGA005151-PA Bombyx mori (silk worm) ENSBTAP00000020715 Bos taurus (bovine) CAL0005346 Candida albicans (a form of yeast) CN12865 Caenorhabditis brenneri (small nematode) CBP29686 Caenorhabditis briggsae (nematode) CE03558 Caenorhabditis elegans (worm) ENSCAFP00000002480 Canis familiaris (dog) CAGL0F04939g Candida glabrata (haploid yeast) Chro.70329 Cryptosporidium hominis (obligate parasite) ENSCINP00000006895 Ciona intestinalis (sea squirt) JA04634 Caenorhabditis japonica (nematode) CMF173C Cyanidioschyzon merolae (red alga) cn02041 Cryptococcus neoformans (yeast-like fungus) cgd7_2920 Cryptosporidium parvum (protozoan parasite) CPIJ008678 Culex pipens (mosquito) ENSCPOP00000018592 Cavia porcellus (guinea pig) 171623 Chlamidomonas reinhardtii (green alga) RP14628 Caenorhabditis remanei (nematode) 155362 Capitella spl (polychaete worm) DDB0232354 Dictyostelium discoideum (amoeba) DEHA2F02112g Debaryomyces Hansenii (yeast) 227386 Daphnia pulex (daphnia) ENSDARP00000018877 Danio rerio (zebra fish) ENSECAP00000012037 Equus caballus (horse) XP_648784 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000008980 Gymnopilus aculeatus (mushroom) ENSGALP00000020463 Gallus gallus (chicken) GL50803_89112 Giardia lamblia (flagellated protozoan) 113800 Hypsipyla robusta (cedar shoot borer) ENSP00000216122 Homo sapiens (human) ISCW020884-PA Ixodes scapularis (deer tick) KLLA0D09262g Kluyveromyces lactis (yeast) 191134 Lottia gigantea (owl limpet) LmjF24.0910 Leishmania major (virus) 27771 Monocosta brevicollis (choanoflagellate) ENSMMUP00000027708 Macaca mulatta (rhesus monkey) ENSMUSP00000005545 Mus musculus (house mouse) 238608 Nematostella vectensis (starlet anemone) XP_001600627.1 Nasonia vitripennis (wasp) ENSOANP00000017224 Ornithorynchus anatinus (platypus) ENSORLP00000013186 Oryzias latipes (japanese killifish) LOC_Os02g55410.1 Oryza sativa (asian rice) 16835 Ostreococcus tauri (green alga) PFL0580w Plasmodium falciparum (protozoal parasite) PHUM000931-PA Pediculus humanus (human body louse) PP29405 Pristionchus pacificus (nematode) 152166 Physcomitrella patens (moss) ENSPPYP00000013122 Pongo pygmaeus (orangutan) 53904 Phytophthora ramorum (sudden oak death pathogen) 135552 Phytophthora sojae (root rot pathogen) 832008 Populus trichocarpa (black cottonwood) ENSPTRP00000024625 Pan troglodytes (chimpanzee) PVX_084615 Plasmodium vivax (protozoal parasite) ENSRNOP00000019677 Rattus norvegicus (norway rat) 4758311 Sorghum bicolor (sorghum) YLR274W Saccharomyces cerevisiae (budding yeast) Smp_143490 Schistosoma mansoni (trematode parasite) SPAC1B2.05 Schizosaccharomyces pombe (fission yeast) XP_001177251.1 Strongylocentrotus purpuratus (purple sea urchin) 50365 Trichoplax adhaerens (metazoa) TA06695 Theileria annulata (apicomplexan parasite) XP_974797.1 Tribolium castaneum (red flour beetle) Tc00.1047053508647.140 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000009012 Tetraodon nigroviridis (green spotted pufferfish) TP01_0722 Theileria parva (parasitic protozoan) 31609 Thalassiosira pseudonana (marine diatom) ENSTRUP00000017534 Takifugu rubripes (pufferfish Takifugu) 3707.m00267 Tetrahymena thermophila (ciliate protozoa) 97026.m00047 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000000515 Xenopus tropicalis (frog) YALI0A01353g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11133 NV16094 LH22204 ISCW020884 FBgn0243091 FBgn0215905 FBgn0197863 FBgn0190230 FBgn0178762 JGI_V11_227386 FBgn0077952 FBgn0159508 FBgn0146462 FBgn0125527 FBgn0109916 FBgn0094921 CPIJ008678 BGIBMGA005151 ACYPI008927 GB12920 AGAP004408 AAEL002810 PHUM514040 GLEAN_09146
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	20582 y1 w67c23; P{wHy}Mcm5DG12108 35679 y1 sc* v1; P{TRiP.GLV21044}attP2
VDRC	v108598 P{KK101583}VIE-260B v13639 w1118; P{GD4229}v13639
Genomic Clones ( 3 )
	BACR15J23 BACR29B06 BACR32N16 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 80 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE67590
Other clones	DPiM_RE67590
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH26086 GM17155 LD04547 LD05417 LD05864 LD07503 LD08363 LD19901 LD21083 LD23609 LD26670 LD28351 LD30662 LD33376 LD35411 LD36139 LD36452 LD36749 LD36763 LD37477 LD39517 LD42405 LD42478 RE07524 RE33890 RE35963 RE38920 RE39025 RE40071 RE47174 RE48584 RE55529 RE57955 RE65546 RE66581 RE66765 RE70015 RE72317 RE74203 SD17073 SD17483
Other clones	52929 180726 183317 Dmel_dig_001252_0597_0487 Dmel_dig_006027_0672_3166 EC052731 EK168733 EK288116 FGC013E08 FGM304H12 RP003027044 RP003037429 RP003057107 RP003060935 RP003089191 RP003094953 RP003108174 RP003116781 RP003188977 RP003207664 RP003245988 RP003262063 RP003273968 RP003306532 RP003319534 RP003346214 RP003356486 RP003437545 RP003458260 RP003469633 RP003488708 RP003630758 RP003630859 RP003630915 RP003662149 RP003667950 UUGC0825
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0017577 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41296
Antibody Information
	polyclonal (Su et al., 1997)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	Mcm5 has a role in mitotic DNA replication. Mcm5 also has a function in the maturation of double strand breaks into crossovers during meiosis. (Lake et al., 2007) The Sld5, Psf1, Psf2, Psf3, CDC45L, Mcm2, Mcm3, Mcm5, Mcm6, Mcm7 and dpa proteins form the Cdc45/Mcm2-7/GINS (CMG) complex, a helicase required for the S phase transition in Kc cells. (Moyer et al., 2006) Mcm5 is a member of a gene family with extensive sequence identity to the MCM (minichromosome maintenance) genes of S.cerevisiae. (Su et al., 1997) Physical interactions exist between three MCM proteins, dpa, Mcm2 and Mcm5. The three proteins reside predominantly in stable multi-protein complexes of about 600kD. Coimmunoprecipitation experiments indicate there are at least two distinct 600kD complexes, one of which includes Mcm5 and the other dpa. (Su et al., 1996)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079584 RefSeq (Proteins) • NP_524308 DDBJ / EMBL / GenBank • AAC47652 AAF54557 AAL49250 AY071628 BI484482 U83493 Entrez Gene - A searchable database of RefSeq genes. • 41296 UniProtKB/TrEMBL • Q9VGW6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Mini-chromosome maintenance, conserved site (IPR018525) Mini-chromosome maintenance, DNA-dependent ATPase (IPR001208) Mini-chromosome maintenance complex protein 5 (IPR008048) ATPase, AAA+ type, core (IPR003593) Nucleic acid-binding, OB-fold (IPR012340) Nucleic acid-binding, OB-fold-like (IPR016027)
Linkouts
	BioGRID - A database of protein and genetic interactions • 66440 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0017577 DroID - A comprehensive database of gene and protein interactions. • FBgn0017577 DRSC - Results from RNAi screens. • FBgn0017577 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0017577 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4082-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0017577 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41296 InParanoid A subset of ortholog calls from InParanoid. • AAEL002810-PA Aedes aegypti (mosquito) AGAP004408-PA Anopheles gambiae (mosquito) XP_624292.1 Apis mellifera (honey bee) XP_001950445.1 Acyrthosiphon pisum (pea aphid) At2g07690.1 Arabidopsis thaliana (wall cress) 13316 Batrachochytrium dendrobatidis (chytrid fungus) 120523 Branchiostoma floridae (lancelet) 121597 Branchiostoma floridae (lancelet) XP_001896354.1 Brugia malayi (roundworm nematode) BGIBMGA005151-PA Bombyx mori (silk worm) ENSBTAP00000020715 Bos taurus (bovine) CAL0005346 Candida albicans (a form of yeast) CN12865 Caenorhabditis brenneri (small nematode) CBP29686 Caenorhabditis briggsae (nematode) CE03558 Caenorhabditis elegans (worm) ENSCAFP00000002480 Canis familiaris (dog) CAGL0F04939g Candida glabrata (haploid yeast) Chro.70329 Cryptosporidium hominis (obligate parasite) ENSCINP00000006895 Ciona intestinalis (sea squirt) JA04634 Caenorhabditis japonica (nematode) CMF173C Cyanidioschyzon merolae (red alga) cn02041 Cryptococcus neoformans (yeast-like fungus) cgd7_2920 Cryptosporidium parvum (protozoan parasite) CPIJ008678 Culex pipens (mosquito) ENSCPOP00000018592 Cavia porcellus (guinea pig) 171623 Chlamidomonas reinhardtii (green alga) RP14628 Caenorhabditis remanei (nematode) 155362 Capitella spl (polychaete worm) DDB0232354 Dictyostelium discoideum (amoeba) DEHA2F02112g Debaryomyces Hansenii (yeast) 227386 Daphnia pulex (daphnia) ENSDARP00000018877 Danio rerio (zebra fish) ENSECAP00000012037 Equus caballus (horse) XP_648784 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000008980 Gymnopilus aculeatus (mushroom) ENSGALP00000020463 Gallus gallus (chicken) GL50803_89112 Giardia lamblia (flagellated protozoan) 113800 Hypsipyla robusta (cedar shoot borer) ENSP00000216122 Homo sapiens (human) ISCW020884-PA Ixodes scapularis (deer tick) KLLA0D09262g Kluyveromyces lactis (yeast) 191134 Lottia gigantea (owl limpet) LmjF24.0910 Leishmania major (virus) 27771 Monocosta brevicollis (choanoflagellate) ENSMMUP00000027708 Macaca mulatta (rhesus monkey) ENSMUSP00000005545 Mus musculus (house mouse) 238608 Nematostella vectensis (starlet anemone) XP_001600627.1 Nasonia vitripennis (wasp) ENSOANP00000017224 Ornithorynchus anatinus (platypus) ENSORLP00000013186 Oryzias latipes (japanese killifish) LOC_Os02g55410.1 Oryza sativa (asian rice) 16835 Ostreococcus tauri (green alga) PFL0580w Plasmodium falciparum (protozoal parasite) PHUM000931-PA Pediculus humanus (human body louse) PP29405 Pristionchus pacificus (nematode) 152166 Physcomitrella patens (moss) ENSPPYP00000013122 Pongo pygmaeus (orangutan) 53904 Phytophthora ramorum (sudden oak death pathogen) 135552 Phytophthora sojae (root rot pathogen) 832008 Populus trichocarpa (black cottonwood) ENSPTRP00000024625 Pan troglodytes (chimpanzee) PVX_084615 Plasmodium vivax (protozoal parasite) ENSRNOP00000019677 Rattus norvegicus (norway rat) 4758311 Sorghum bicolor (sorghum) YLR274W Saccharomyces cerevisiae (budding yeast) Smp_143490 Schistosoma mansoni (trematode parasite) SPAC1B2.05 Schizosaccharomyces pombe (fission yeast) XP_001177251.1 Strongylocentrotus purpuratus (purple sea urchin) 50365 Trichoplax adhaerens (metazoa) TA06695 Theileria annulata (apicomplexan parasite) XP_974797.1 Tribolium castaneum (red flour beetle) Tc00.1047053508647.140 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000009012 Tetraodon nigroviridis (green spotted pufferfish) TP01_0722 Theileria parva (parasitic protozoan) 31609 Thalassiosira pseudonana (marine diatom) ENSTRUP00000017534 Takifugu rubripes (pufferfish Takifugu) 3707.m00267 Tetrahymena thermophila (ciliate protozoa) 97026.m00047 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000000515 Xenopus tropicalis (frog) YALI0A01353g Yarrowia lipolytica (nonconventional yeast) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/mcm5.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41296 modMine - Data generated by the modENCODE project. • FBgn0017577 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11133 NV16094 LH22204 ISCW020884 FBgn0243091 FBgn0215905 FBgn0197863 FBgn0190230 FBgn0178762 JGI_V11_227386 FBgn0077952 FBgn0159508 FBgn0146462 FBgn0125527 FBgn0109916 FBgn0094921 CPIJ008678 BGIBMGA005151 ACYPI008927 GB12920 AGAP004408 AAEL002810 PHUM514040 GLEAN_09146
Synonyms & Secondary IDs ( 14 )
Reported As
Symbol Synonym	CG4082 (Jin et al., 2001, Sandmann et al., 2006, Keleman et al., 2009.8.5, Ni et al., 2011.7.19) DmCDC46   DmCDC465 (Su et al., 1996) DmeMCM5 (Blanton et al., 2005) DmMcm5 (Loebel et al., 2000) DmMCM5 (Su, 1996.12.31, Ohno et al., 1998, Kearsey and Labib, 1998, Su and O'Farrell, 1998, Su and O'Farrell, 1997, Su et al., 1997, ) MCM5 (Claycomb et al., 2002, Crevel et al., 2001, Feger, 1999, Crevel et al., 2007, Hediger and Gasser, 2006, Hong et al., 2007, Ilves et al., 2010, Gallone et al., 2011) mcm5 (Jasper et al., 2002, Lake and Hawley, 2006, Nielsen et al., 2006, Arbouzova and Zeidler, 2006, Tanneti et al., 2008, Lake et al., 2007, Park and Asano, 2008, Page et al., 2007) Mcm5 (Moyer et al., 2006, Foglietti et al., 2006, Cayirlioglu et al., 2003, Wawersik et al., 2005, Casper and Van Doren, 2009, Baig et al., 2010, Wasbrough et al., 2010) McM5 (De Lucia et al., 2005) PCR4 (Su et al., 1997)
Name Synonym	Minichromosome maintenance 5 (Casper and Van Doren, 2006, Baig et al., 2010) minichromosome maintenance 5 (Page et al., 2007) mini-chromosome maintenance 5 (Casper and Van Doren, 2009)
Secondary FlyBase IDs
References ( 59 )
Generate a list of	All references relating to this gene ( 59 )
List References by type	Research paper  ( 34 ) Supplementary material  ( 4 ) Review  ( 6 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 3 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 3 )
	Gallone et al., 2011, BMC Bioinformatics 12: 289 Bio::Homology::InterologWalk - A Perl module to build putative protein-protein interaction networks through interolog mapping. [FBrf0214774] Baig et al., 2010, Genetics 184(3): 731--744 The chromatin-remodeling protein Osa interacts with CyclinE in Drosophila eye imaginal discs. [FBrf0210399] Ilves et al., 2010, Mol. Cell 37(2): 247--258 Activation of the MCM2-7 Helicase by Association with Cdc45 and GINS Proteins. [FBrf0209843] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...