• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\Lk6

General Information
Symbol	Dmel\Lk6	Species	D. melanogaster
Name	Lk6	Annotation symbol	CG17342
Feature type	protein_coding_gene	FlyBase ID	FBgn0017581
Gene Model Status	Current	Stock availability	37 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map	3-
Cytogenetic map	86E18-86E18	Sequence location	3R:7,578,506..7,590,179 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Lk6 is referred to in FlyBase by the symbol Dmel\Lk6 (CG17342, FBgn0017581). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein kinase activity; kinase activity. There is experimental evidence that it is involved in the biological process: microtubule-based process; regulation of growth. 63 alleles are reported. The phenotypes of these alleles are annotated with: larva; adult; salivary gland; trichogen cell; egg; mesothoracic tergum; embryonic/larval fat body; second instar larva; wing. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine-protein kinase, active site; Serine/threonine-protein kinase, catalytic domain; Serine/threonine-protein kinase-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed within 00-12 hour embryonic stages, during early pupal stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult testis. Comments on Affy2 ProbeSet: ProbeSet 1641654_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Lk6. Gene sequence location is 3R:7578506..7590179.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	References Guenin et al., 2010, BMC Genomics 11: 47 Sequence features BKN50344 BKN50083 BKN22673 HFA12867 HFA16728
FB2011_10	References Knowles-Barley, 2011.8.24, BrainTrap expression curation.
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 86E18-86E18   Limits computationally determined from genome sequence between P{PZ}tho1&P{PZ}l(3)0462905275 and P{EP}Lk6EP886
Experimentally Determined Cytological Location
Cytogenetic map Notes References 86F6-86F7   (determined by in situ hybridisation)   (Huang and Rubin, 2000) 86F1-86F11     (Raff, 1996.10.28)
Experimentally Determined Recombination Data
Location	3- (Raff, 1996.10.28)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Lk6 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	DGC clone LD31983 appears problematic: incomplete CDS (at 3' end).
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Lk6-RA FBtr0082534  NM_143729   4428   1142 Lk6-RB FBtr0082535  NM_169423   3979   1090
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Lk6-PA   FBpp0082008   128.5   1142   4.94     NP_651986   AAF54694 Lk6-PB   FBpp0082009   123.4   1090   4.89     NP_731624   AAF54695
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, ATP binding site (IPR017441) Protein kinase, catalytic domain (IPR000719) Serine/threonine-protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Serine/threonine-protein kinase-like domain (IPR017442)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA391006   AA391705   AA392720   AA539506   AA539609   AA539651   AA541029   AA567421   AA567792   AA567810   AA694832   AA695484   AA697540   AA697723   AA698294   AA698677   AA801518   AA802420   AA816803   AA820935   AA821106   AA942302   AA951499   AE014297 AAF54694   AE014297 AAF54695   AI114066   AI135417   AI256979   AI259485   AI514693   AI517767   AI531484   AI532285   AI534020   AI542628   AI543485   AQ025274   AQ073923   AQ254663   AW943107   AX260122   AY075405   BF485867   BF486137   BF486806   BF489770   BF492937   BF492938   BF494510   BF495122   BF495635   BF505350   BG641375   BH740723   BI161501   BI161502   BI164960   BI168061   BI168188   BI236453   BI579138   BI605024   BI627534   BI632831   BI635146   BI636650   BI636678   BI640271   BI640717   BP553118   BP557591   BP557592   BP559379   BP559380   BQ102944   BT011072   BT050542   BZ286280   BZ665510   CK661322   CL943608   CO154402   CO177424   CO178916   CO273026   CO277944   CO281836   CO283165   CO283832   CO288566   CO296532   CO298478   CO313718   CO315410   CO316535   CO318083   CO318552   CO325427   CO329893   CO333021   CO333852   CO336195   CO338033   CO338135   CO338761   CZ466441   CZ470151   CZ472705   CZ477034   CZ484063   DN154187   EC051024   EC053036   EC053513   EC057164   EC057756   EC063967   EC067737   EC067977   EC071912   EC073798   EC082604   EC083989   EC086321   EC089248   EC090694   EC207576   EC216243   EC220428   EC222542   EC222750   EC225647   EC226879   EC228378   EC238876   EC241582   EC241722   EC247643   EC250047   EC250197   EC261622   EC262355   EC262586   EC265054   EC265259   EC267390   ES691145   ES691199   ES691556   ES694119   ES695115   EV576562   EV578809   EV580704   EV583909   EV585677   EV596236   EV598930   EV600457   U76378 AAB18789
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q94548 Q9VGI4 Q9VGI5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0017581    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0017581 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed within 00-12 hour embryonic stages, during early pupal stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0017581 expression level Developmental Stage   Expression Level embryo 00-02hr    16511 embryo 02-04hr    20160 embryo 04-06hr    14107 embryo 06-08hr    11928 embryo 08-10hr    11166 embryo 10-12hr    5655 embryo 12-14hr    7401 embryo 14-16hr    8021 embryo 16-18hr    6342 embryo 18-20hr    5432 embryo 20-22hr    7257 embryo 22-24hr    7875 larva L1    5300 larva L2    4185 larva L3 12hr old    5366 larva L3 puffstage 1-2    5526 larva L3 puffstage 3-6    9300 larva L3 puffstage 7-9    7627 white prepupae new    6541 white prepupae 12hr    9460 white prepupae 24hr    12783 pupae 2d postWPP    9880 pupae 3d postWPP    6426 pupae 4d postWPP    8231 adult male 01day    13496 adult male 05day    18003 adult male 30day    24242 adult female 01day    14556 adult female 05day    15486 adult female 30day    15669 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (16511) embryo 02-04hr  (20160) embryo 04-06hr  (14107) embryo 06-08hr  (11928) embryo 08-10hr  (11166) embryo 10-12hr  (5655) embryo 12-14hr  (7401) embryo 14-16hr  (8021) embryo 16-18hr  (6342) embryo 18-20hr  (5432) embryo 20-22hr  (7257) embryo 22-24hr  (7875) larva L1  (5300) larva L2  (4185) larva L3 12hr old  (5366) larva L3 puffstage 1-2  (5526) larva L3 puffstage 3-6  (9300) larva L3 puffstage 7-9  (7627) white prepupae new  (6541) white prepupae 12hr  (9460) white prepupae 24hr  (12783) pupae 2d postWPP  (9880) pupae 3d postWPP  (6426) pupae 4d postWPP  (8231) adult male 01day  (13496) adult male 05day  (18003) adult male 30day  (24242) adult female 01day  (14556) adult female 05day  (15486) adult female 30day  (15669) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (16511) embryo 02-04hr  (20160) embryo 04-06hr  (14107) embryo 06-08hr  (11928) embryo 08-10hr  (11166) embryo 10-12hr  (5655) embryo 12-14hr  (7401) embryo 14-16hr  (8021) embryo 16-18hr  (6342) embryo 18-20hr  (5432) embryo 20-22hr  (7257) embryo 22-24hr  (7875) larva L1  (5300) larva L2  (4185) larva L3 12hr old  (5366) larva L3 puffstage 1-2  (5526) larva L3 puffstage 3-6  (9300) larva L3 puffstage 7-9  (7627) white prepupae new  (6541) white prepupae 12hr  (9460) white prepupae 24hr  (12783) pupae 2d postWPP  (9880) pupae 3d postWPP  (6426) pupae 4d postWPP  (8231) adult male 01day  (13496) adult male 05day  (18003) adult male 30day  (24242) adult female 01day  (14556) adult female 05day  (15486) adult female 30day  (15669) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (16511) embryo 02-04hr  (20160) embryo 04-06hr  (14107) embryo 06-08hr  (11928) embryo 08-10hr  (11166) embryo 10-12hr    5655 embryo 12-14hr    7401 embryo 14-16hr    8021 embryo 16-18hr    6342 embryo 18-20hr    5432 embryo 20-22hr    7257 embryo 22-24hr    7875 larva L1    5300 larva L2    4185 larva L3 12hr old    5366 larva L3 puffstage 1-2    5526 larva L3 puffstage 3-6    9300 larva L3 puffstage 7-9    7627 white prepupae new    6541 white prepupae 12hr    9460 white prepupae 24hr  (12783) pupae 2d postWPP    9880 pupae 3d postWPP    6426 pupae 4d postWPP    8231 adult male 01day  (13496) adult male 05day  (18003) adult male 30day  (24242) adult female 01day  (14556) adult female 05day  (15486) adult female 30day  (15669) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    16511 embryo 02-04hr    20160 embryo 04-06hr    14107 embryo 06-08hr    11928 embryo 08-10hr    11166 embryo 10-12hr    5655 embryo 12-14hr    7401 embryo 14-16hr    8021 embryo 16-18hr    6342 embryo 18-20hr    5432 embryo 20-22hr    7257 embryo 22-24hr    7875 larva L1    5300 larva L2    4185 larva L3 12hr old    5366 larva L3 puffstage 1-2    5526 larva L3 puffstage 3-6    9300 larva L3 puffstage 7-9    7627 white prepupae new    6541 white prepupae 12hr    9460 white prepupae 24hr    12783 pupae 2d postWPP    9880 pupae 3d postWPP    6426 pupae 4d postWPP    8231 adult male 01day    13496 adult male 05day    18003 adult male 30day    24242 adult female 01day    14556 adult female 05day    15486 adult female 30day    15669 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0017581 expression level Developmental Stage   Expression Level embryo 00-02hr    16511 embryo 02-04hr    20160 embryo 04-06hr    14107 embryo 06-08hr    11928 embryo 08-10hr    11166 embryo 10-12hr    5655 embryo 12-14hr    7401 embryo 14-16hr    8021 embryo 16-18hr    6342 embryo 18-20hr    5432 embryo 20-22hr    7257 embryo 22-24hr    7875 larva L1    5300 larva L2    4185 larva L3 12hr old    5366 larva L3 puffstage 1-2    5526 larva L3 puffstage 3-6    9300 larva L3 puffstage 7-9    7627 white prepupae new    6541 white prepupae 12hr    9460 white prepupae 24hr    12783 pupae 2d postWPP    9880 pupae 3d postWPP    6426 pupae 4d postWPP    8231 adult male 01day    13496 adult male 05day    18003 adult male 30day    24242 adult female 01day    14556 adult female 05day    15486 adult female 30day    15669 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (16511) embryo 02-04hr  (20160) embryo 04-06hr  (14107) embryo 06-08hr  (11928) embryo 08-10hr  (11166) embryo 10-12hr  (5655) embryo 12-14hr  (7401) embryo 14-16hr  (8021) embryo 16-18hr  (6342) embryo 18-20hr  (5432) embryo 20-22hr  (7257) embryo 22-24hr  (7875) larva L1  (5300) larva L2  (4185) larva L3 12hr old  (5366) larva L3 puffstage 1-2  (5526) larva L3 puffstage 3-6  (9300) larva L3 puffstage 7-9  (7627) white prepupae new  (6541) white prepupae 12hr  (9460) white prepupae 24hr  (12783) pupae 2d postWPP  (9880) pupae 3d postWPP  (6426) pupae 4d postWPP  (8231) adult male 01day  (13496) adult male 05day  (18003) adult male 30day  (24242) adult female 01day  (14556) adult female 05day  (15486) adult female 30day  (15669) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (16511) embryo 02-04hr  (20160) embryo 04-06hr  (14107) embryo 06-08hr  (11928) embryo 08-10hr  (11166) embryo 10-12hr  (5655) embryo 12-14hr  (7401) embryo 14-16hr  (8021) embryo 16-18hr  (6342) embryo 18-20hr  (5432) embryo 20-22hr  (7257) embryo 22-24hr  (7875) larva L1  (5300) larva L2  (4185) larva L3 12hr old  (5366) larva L3 puffstage 1-2  (5526) larva L3 puffstage 3-6  (9300) larva L3 puffstage 7-9  (7627) white prepupae new  (6541) white prepupae 12hr  (9460) white prepupae 24hr  (12783) pupae 2d postWPP  (9880) pupae 3d postWPP  (6426) pupae 4d postWPP  (8231) adult male 01day  (13496) adult male 05day  (18003) adult male 30day  (24242) adult female 01day  (14556) adult female 05day  (15486) adult female 30day  (15669) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  16511 embryo 02-04hr  20160 embryo 04-06hr  14107 embryo 06-08hr  11928 embryo 08-10hr  11166 embryo 10-12hr    5655 embryo 12-14hr    7401 embryo 14-16hr    8021 embryo 16-18hr    6342 embryo 18-20hr    5432 embryo 20-22hr    7257 embryo 22-24hr    7875 larva L1    5300 larva L2    4185 larva L3 12hr old    5366 larva L3 puffstage 1-2    5526 larva L3 puffstage 3-6    9300 larva L3 puffstage 7-9    7627 white prepupae new    6541 white prepupae 12hr    9460 white prepupae 24hr  12783 pupae 2d postWPP    9880 pupae 3d postWPP    6426 pupae 4d postWPP    8231 adult male 01day  13496 adult male 05day  18003 adult male 30day  (24242) adult female 01day  14556 adult female 05day  15486 adult female 30day  15669 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    16511 embryo 02-04hr    20160 embryo 04-06hr    14107 embryo 06-08hr    11928 embryo 08-10hr    11166 embryo 10-12hr    5655 embryo 12-14hr    7401 embryo 14-16hr    8021 embryo 16-18hr    6342 embryo 18-20hr    5432 embryo 20-22hr    7257 embryo 22-24hr    7875 larva L1    5300 larva L2    4185 larva L3 12hr old    5366 larva L3 puffstage 1-2    5526 larva L3 puffstage 3-6    9300 larva L3 puffstage 7-9    7627 white prepupae new    6541 white prepupae 12hr    9460 white prepupae 24hr    12783 pupae 2d postWPP    9880 pupae 3d postWPP    6426 pupae 4d postWPP    8231 adult male 01day    13496 adult male 05day    18003 adult male 30day    24242 adult female 01day    14556 adult female 05day    15486 adult female 30day    15669 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0017581    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0017581 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0017581 expression level Tissue   Expression Level Larval Central Nervous System    924.425 Larval Midgut    1107.9 Larval Hindgut    1247.9 Larval Malpighian Tubules    990.2 Larval Fat Body    784.9 Larval Salivary Gland    906.6 Larval Trachea    1550.475 Larval Carcass    830.35 Adult Head    1919.8 Adult Eye    4362.075 Adult Brain    1468.2 Adult Thoracic-Abdominal Ganglion    1897.5 Adult Crop    2193 Adult Midgut    890.3 Adult Hindgut    1600 Adult Malpighian Tubules    991.9 Adult Fat Body    1336.2 Adult Salivary Gland    4243.7 Adult Heart    2228.325 Adult VirginFemale Spermatheca    1841.4 Adult InseminatedFemale Spermatheca    1277.8 Adult Ovary    814.8 Adult Testis    385.8 Adult Male Accessory Gland    1992.6 Adult Carcass    2251.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (924.425) Larval Midgut  (1107.9) Larval Hindgut  (1247.9) Larval Malpighian Tubules  (990.2) Larval Fat Body  (784.9) Larval Salivary Gland  (906.6) Larval Trachea  (1550.475) Larval Carcass  (830.35) Adult Head  (1919.8) Adult Eye  (4362.075) Adult Brain  (1468.2) Adult Thoracic-Abdominal Ganglion  (1897.5) Adult Crop  (2193) Adult Midgut  (890.3) Adult Hindgut  (1600) Adult Malpighian Tubules  (991.9) Adult Fat Body  (1336.2) Adult Salivary Gland  (4243.7) Adult Heart  (2228.325) Adult VirginFemale Spermatheca  (1841.4) Adult InseminatedFemale Spermatheca  (1277.8) Adult Ovary  (814.8) Adult Testis    385.8 Adult Male Accessory Gland  (1992.6) Adult Carcass  (2251.9) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    924.425 Larval Midgut  (1107.9) Larval Hindgut  (1247.9) Larval Malpighian Tubules    990.2 Larval Fat Body    784.9 Larval Salivary Gland    906.6 Larval Trachea  (1550.475) Larval Carcass    830.35 Adult Head  (1919.8) Adult Eye  (4362.075) Adult Brain  (1468.2) Adult Thoracic-Abdominal Ganglion  (1897.5) Adult Crop  (2193) Adult Midgut    890.3 Adult Hindgut  (1600) Adult Malpighian Tubules    991.9 Adult Fat Body  (1336.2) Adult Salivary Gland  (4243.7) Adult Heart  (2228.325) Adult VirginFemale Spermatheca  (1841.4) Adult InseminatedFemale Spermatheca  (1277.8) Adult Ovary    814.8 Adult Testis    385.8 Adult Male Accessory Gland  (1992.6) Adult Carcass  (2251.9) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    924.425 Larval Midgut    1107.9 Larval Hindgut    1247.9 Larval Malpighian Tubules    990.2 Larval Fat Body    784.9 Larval Salivary Gland    906.6 Larval Trachea    1550.475 Larval Carcass    830.35 Adult Head    1919.8 Adult Eye    4362.075 Adult Brain    1468.2 Adult Thoracic-Abdominal Ganglion    1897.5 Adult Crop    2193 Adult Midgut    890.3 Adult Hindgut    1600 Adult Malpighian Tubules    991.9 Adult Fat Body    1336.2 Adult Salivary Gland    4243.7 Adult Heart    2228.325 Adult VirginFemale Spermatheca    1841.4 Adult InseminatedFemale Spermatheca    1277.8 Adult Ovary    814.8 Adult Testis    385.8 Adult Male Accessory Gland    1992.6 Adult Carcass    2251.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0017581 expression level Tissue   Expression Level Larval Central Nervous System    924.425 Larval Midgut    1107.9 Larval Hindgut    1247.9 Larval Malpighian Tubules    990.2 Larval Fat Body    784.9 Larval Salivary Gland    906.6 Larval Trachea    1550.475 Larval Carcass    830.35 Adult Head    1919.8 Adult Eye    4362.075 Adult Brain    1468.2 Adult Thoracic-Abdominal Ganglion    1897.5 Adult Crop    2193 Adult Midgut    890.3 Adult Hindgut    1600 Adult Malpighian Tubules    991.9 Adult Fat Body    1336.2 Adult Salivary Gland    4243.7 Adult Heart    2228.325 Adult VirginFemale Spermatheca    1841.4 Adult InseminatedFemale Spermatheca    1277.8 Adult Ovary    814.8 Adult Testis    385.8 Adult Male Accessory Gland    1992.6 Adult Carcass    2251.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (924.425) Larval Midgut  (1107.9) Larval Hindgut  (1247.9) Larval Malpighian Tubules  (990.2) Larval Fat Body  784.9 Larval Salivary Gland  (906.6) Larval Trachea  (1550.475) Larval Carcass  (830.35) Adult Head  (1919.8) Adult Eye  (4362.075) Adult Brain  (1468.2) Adult Thoracic-Abdominal Ganglion  (1897.5) Adult Crop  (2193) Adult Midgut  (890.3) Adult Hindgut  (1600) Adult Malpighian Tubules  (991.9) Adult Fat Body  (1336.2) Adult Salivary Gland  (4243.7) Adult Heart  (2228.325) Adult VirginFemale Spermatheca  (1841.4) Adult InseminatedFemale Spermatheca  (1277.8) Adult Ovary  (814.8) Adult Testis    385.8 Adult Male Accessory Gland  (1992.6) Adult Carcass  (2251.9) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    924.425 Larval Midgut  1107.9 Larval Hindgut  1247.9 Larval Malpighian Tubules    990.2 Larval Fat Body    784.9 Larval Salivary Gland    906.6 Larval Trachea  1550.475 Larval Carcass    830.35 Adult Head  (1919.8) Adult Eye  (4362.075) Adult Brain  1468.2 Adult Thoracic-Abdominal Ganglion  (1897.5) Adult Crop  (2193) Adult Midgut    890.3 Adult Hindgut  1600 Adult Malpighian Tubules    991.9 Adult Fat Body  1336.2 Adult Salivary Gland  (4243.7) Adult Heart  (2228.325) Adult VirginFemale Spermatheca  (1841.4) Adult InseminatedFemale Spermatheca  1277.8 Adult Ovary    814.8 Adult Testis    385.8 Adult Male Accessory Gland  (1992.6) Adult Carcass  (2251.9) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    924.425 Larval Midgut    1107.9 Larval Hindgut    1247.9 Larval Malpighian Tubules    990.2 Larval Fat Body    784.9 Larval Salivary Gland    906.6 Larval Trachea    1550.475 Larval Carcass    830.35 Adult Head    1919.8 Adult Eye    4362.075 Adult Brain    1468.2 Adult Thoracic-Abdominal Ganglion    1897.5 Adult Crop    2193 Adult Midgut    890.3 Adult Hindgut    1600 Adult Malpighian Tubules    991.9 Adult Fat Body    1336.2 Adult Salivary Gland    4243.7 Adult Heart    2228.325 Adult VirginFemale Spermatheca    1841.4 Adult InseminatedFemale Spermatheca    1277.8 Adult Ovary    814.8 Adult Testis    385.8 Adult Male Accessory Gland    1992.6 Adult Carcass    2251.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1919.8   NA  Eye    4362.075   NA  Brain    1468.2   924.425  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1897.5   NA  Crop    2193   1107.9  Midgut    890.3   1247.9  Hindgut    1600   990.2  Malpighian Tubules    991.9   784.9  Fat Body    1336.2   906.6  Salivary Gland    4243.7   NA  Heart    2228.325   1550.475  Trachea    NA   NA  VirginFemale Spermatheca    1841.4   NA  InseminatedFemale Spermatheca    1277.8   NA  Ovary    814.8   NA  Testis    385.8   NA  Male Accessory Gland    1992.6   830.35  Carcass    2251.9 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_21
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0017581 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17342-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4Act5C.PU Lk6EP30.18 lethal | partially (with Lk61) Lk62 lethal | partially (with Lk62) Lk61 lethal | partially | recessive Lk61 lethal | recessive | second instar larval stage Lk62 semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 Lk6GD3921 Lk6GD9353 viable Lk6EY14119 Lk6GSG1142 Lk6KKO.Ubi-p63E viable, with Scer\GAL4[-]: Lk615 Lk625 Lk626 Lk638 Lk6EP886 Lk6EP3094 viable, with Scer\GAL4Act5C.PU Lk615 Lk625 Lk626 Lk636 Lk638 Sterility Allele fertile Lk61 Lk6EY14119 fertile, with Scer\GAL4[-]: Lk615 Lk625 Lk626 Lk638 Other Phenotypes Allele body color defective, with Scer\GAL4pnr-MD237 Lk6GD9353 cell growth defective | somatic clone Lk6unspecified chemical sensitive Lk6unspecified decreased cell number, with Scer\GAL4[-]: Lk615 decreased cell number, with Scer\GAL4da.G32 Lk6EP30.18 decreased cell number (with Lk61) Lk62 decreased cell number (with Lk62) Lk61 decreased cell size, with Scer\GAL4[-]: Lk615 decreased cell size (with Lk61) Lk62 decreased cell size (with Lk62) Lk61 developmental rate defective Lk61 small body Lk61 small body, with Scer\GAL4[-]: Lk615 small body, with Scer\GAL4da.G32 Lk6EP30.18 stress response defective, with Scer\GAL4[-]: Lk615 visible, with Scer\GAL4pnr-MD237 Lk6GD3921 Lk6GD9353 wild-type, with Scer\GAL4da.G32 Lk6Scer\UAS.cAa Phenotype manifest in Allele adult Lk61 adult (with Lk61) Lk62 adult (with Lk62) Lk61 chaeta | supernumerary, with Scer\GAL4pnr-MD237 Lk6GD3921 egg Lk6Ubi-p63E.PK egg & microtubule Lk6Ubi-p63E.PK embryonic/larval fat body (with Lk61) Lk62 embryonic/larval fat body (with Lk62) Lk61 larva (with Lk61) Lk62 larva (with Lk62) Lk61 mesothoracic tergum, with Scer\GAL4pnr-MD237 Lk6GD3921 Lk6GD9353 salivary gland (with Lk61) Lk62 salivary gland (with Lk62) Lk61 second instar larva Lk62 trichogen cell, with Scer\GAL4pnr-MD237 Lk6GD9353 wing, with Scer\GAL4da.G32 Lk6EP30.18 wing (with Lk61) Lk62 wing (with Lk62) Lk61
Classical Alleles ( 51 )
For All Classical Alleles Show
Allele of Lk6 Class Mutagen Stocks Known lesion Lk61 hypomorphic allele - genetic evidence P-element activity 1 Yes Lk62 loss of function allele P-element activity 1 Yes Lk65-HA-2147 1 -- Lk65-HA-2300 1 -- Lk65-HA-5070 1 -- Lk65-SZ-3309 1 -- Lk6c00414 piggyBac transposase 1 -- Lk6c04963 1 -- Lk6c05644 piggyBac transposase 1 -- Lk6CB-0462-3 1 -- Lk6CB-5822-3 1 -- Lk6d02257 P-element activity 1 -- Lk6d02983 1 -- Lk6DJ634 1 Yes Lk6e02063 1 -- Lk6e03463 1 -- Lk6EY00547 P-element activity 1 -- Lk6EY14119 P-element activity 1 -- Lk6f01598 piggyBac transposase 1 -- Lk6KG01401 P-element activity 1 -- Lk6KG08062 P-element activity 1 -- Lk6MI02556 1 -- Lk6NP0101 1 -- Lk6NP2106 1 -- Lk6NP2107 1 -- Lk6NP2217 1 -- Lk6NP2550 1 -- Lk6NP5427 1 -- Lk6UM-8206-3 1 -- Lk6UM-8218-3 1 -- Lk615 ethyl methanesulfonate 0 Yes Lk625 ethyl methanesulfonate 0 Yes Lk626 ethyl methanesulfonate 0 Yes Lk636 ethyl methanesulfonate 0 Yes Lk638 ethyl methanesulfonate 0 Yes Lk65-SZ-3160 0 -- Lk6CB-6962-3 0 -- Lk6CPTI000056 piggyBac transposase 0 Yes Lk6CPTI000216 piggyBac transposase 0 Yes Lk6d08552 0 -- Lk6d09977 P-element activity 0 -- Lk6EP30.18 0 Yes Lk6EP3094 P-element activity 0 -- Lk6EP3333 P-element activity 0 Yes Lk6EP3344 0 Yes Lk6EP3404 P-element activity 0 -- Lk6EP886 P-element activity 0 -- Lk6GS10110 0 Yes Lk6GSG1142 0 Yes Lk6S050116a P-element activity 0 -- Lk6unspecified 0 --
Alleles Carried on Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Lk6 Class Mutagen Stocks Known lesion Lk6GD3921 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Lk6GD9353 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Lk6GL00264 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Lk6JF02993 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Lk6Scer\UAS.cAa in vitro construct - regulatory fusion 1 Yes Lk6T424D.Scer\UAS in vitro construct - amino acid replacement in vitro construct - regulatory fusion 1 Yes Lk6hs.PK in vitro construct - regulatory fusion 0 Yes Lk6KK102607 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Lk6KKO.Ubi-p63E in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes Lk6Scer\UAS.cHa in vitro construct - regulatory fusion 0 Yes Lk6T:Zzzz\FLAG in vitro construct - coding region fusion 0 Yes Lk6Ubi-p63E.PK in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3921} NA P{GD9353} NA P{KK102607} NA P{TRiP.GL00264} NA P{TRiP.JF02993} NA P{UAS-Lk6.A} NA P{UAS-Lk6.H} NA P{UAS-Lk6.T424D} NA heat-shock construct P{Hsp70-LK6.K} NA characterization construct P{PUBq-KKO} NA P{PUBq-LK6} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}EP603 NA P{EP}EP887 NA P{EP}EP3216 NA P{EP}EP3409 NA P{EP}EP3576 NA P{EP}EP3600 NA P{EP}Lk6EP30.18 NA P{EP}Lk6EP886 NA P{EP}Lk6EP3094 NA P{EP}Lk6EP3333 NA P{EP}Lk6EP3344 NA P{EP}Lk6EP3404 NA P{EP}Myo61FEP3325b NA P{EPgy2}Lk6EY00547 NA P{EPgy2}Lk6EY14119 NA P{GSV1}C441C441 NA P{GSV6}Lk6GS10110 NA P{XP}Lk6d02257 NA P{XP}Lk6d02983 NA P{XP}Lk6d08552 NA P{XP}Lk6d09977 NA miscellaneous insertions Mi{MIC}Lk6MI02556 NA P{PTT-GA}CA06607 NA P{PTT-GB}CB02120 NA P{RS3}Lk6CB-0462-3 NA P{RS3}Lk6CB-5822-3 NA P{RS3}Lk6CB-6962-3 NA P{RS3}Lk6UM-8206-3 NA P{RS3}Lk6UM-8218-3 NA P{RS5}Lk65-HA-2147 NA P{RS5}Lk65-HA-2300 NA P{RS5}Lk65-HA-5070 NA P{RS5}Lk65-SZ-3160 NA P{RS5}Lk65-SZ-3309 NA P{SUPor-P}Lk6KG01401 NA P{SUPor-P}Lk6KG08062 NA P{Switch2}Lk6GSG1142 NA PBac{602.P.SVS-1}Lk6CPTI000056 NA PBac{602.P.SVS-1}Lk6CPTI000216 NA PBac{PB}Lk6c00414 NA PBac{PB}Lk6c04963 NA PBac{PB}Lk6c05644 NA PBac{RB}Lk6e02063 NA PBac{RB}Lk6e03463 NA PBac{WH}Lk6f01598 NA insertion of enhancer trap binary system P{GAL4}ikar1 No P{GawB}Lk6DJ634 No P{GawB}Lk6NP0101 No P{GawB}Lk6NP2106 No P{GawB}Lk6NP2107 No P{GawB}Lk6NP2217 No P{GawB}Lk6NP2550 No P{GawB}Lk6NP5427 No insertion of enhancer trap P{lacW}Lk6S050116a No
Gene Ontology: Function, Process & Cellular Component ( 11 unique terms )
Terms Based on Experimental Evidence ( 8 terms )
Molecular Function
CV term Evidence References
kinase activity inferred from mutant phenotype (Arquier et al., 2005) protein kinase activity inferred from direct assay (Kidd and Raff, 1997)
Biological Process
CV term Evidence References
microtubule-based process inferred from mutant phenotype (Kidd and Raff, 1997) regulation of growth inferred from mutant phenotype (Arquier et al., 2005)
Cellular Component
CV term Evidence References
centrosome inferred from direct assay (Kidd and Raff, 1997) cytoplasm inferred from direct assay (Kidd and Raff, 1997) microtubule inferred from direct assay (Kidd and Raff, 1997) nuclear envelope inferred from direct assay (Kidd and Raff, 1997)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR017441 (FlyBase Curators et al., 2004-) protein serine/threonine kinase activity inferred from sequence or structural similarity with EMBL:Y11092 (FlyBase, 1992-) non-traceable author statement (Morrison et al., 2000)
Biological Process
CV term Evidence References
protein phosphorylation inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR008271 (FlyBase Curators et al., 2004-) non-traceable author statement (Morrison et al., 2000)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Lk6 allele Gene References Lk6EP30.18 eIF-4E (Reiling et al., 2005) Lk6EP886 aret (Yan and Macdonald, 2004) ksr::tor (Huang and Rubin, 2000) Ras85D (Huang and Rubin, 2000) Lk6EP3094 ksr::tor (Huang and Rubin, 2000) Ras85D (Huang and Rubin, 2000) Lk6EP3333 eIF-4E (Arquier et al., 2005) Lk6Scer\UAS.cAa eIF-4E (Arquier et al., 2005) Lk6Scer\UAS.cHa ksr::tor (Huang and Rubin, 2000) Ras85D (Huang and Rubin, 2000) Lk6T424D.Scer\UAS eIF-4E (Arquier et al., 2005) unspecified ksr (Huang and Rubin, 2000) pbl (Gregory et al., 2007)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 69194 DroID - A comprehensive database of gene and protein interactions. • FBgn0017581 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44672
Orthologs
Genome-wide drosophilid orthologs	Dana\GF16618 Dere\GG17196 Dgri\GH19309 Dmoj\GI23525 Dper\GL12250 Dpse\GA14470 Dsec\GM26074 Dsim\GD20638 Dvir\GJ10277 Dwil\GK11984 Dyak\GE10088
Curated drosophilid orthologs	Dpse\GA14470
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL004704-PA Aedes aegypti (mosquito) XP_395927.3 Apis mellifera (honey bee) XP_001951545.1 Acyrthosiphon pisum (pea aphid) 266139 Branchiostoma floridae (lancelet) 281522 Branchiostoma floridae (lancelet) CPIJ003312 Culex pipens (mosquito) ENSCPOP00000013407 Cavia porcellus (guinea pig) 182721 Capitella spl (polychaete worm) LmjF19.0140 Leishmania major (virus) ENSMUSP00000095532 Mus musculus (house mouse) 93027 Nematostella vectensis (starlet anemone) PF11_0464 Plasmodium falciparum (protozoal parasite) YPL153C Saccharomyces cerevisiae (budding yeast) XP_779905.1 Strongylocentrotus purpuratus (purple sea urchin) Tc00.1047053511821.60 Trypanosoma cruzi (parasitic trypanosome) 24596 Thalassiosira pseudonana (marine diatom) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV50310 LH24496 ISCW015270 FBgn0227970 FBgn0213995 FBgn0197563 FBgn0192104 FBgn0180929 JGI_V11_306600 FBgn0074498 FBgn0149858 FBgn0149857 FBgn0146251 FBgn0126774 FBgn0109423 FBgn0093639 CPIJ003313 CPIJ003312 ACYPI006520 GB17530 AGAP003160 AAEL004704 PB24960 PHUM576840 GLEAN_10495
Stocks & Reagents
Stocks Listed in FlyBase ( 37 )
Bloomington	8709 w1118; P{UAS-Lk6.T424D}6 8706 w1118; Lk61/TM6C
Harvard	- P{XP}Lk6d02257 - P{XP}Lk6d02983 - PBac{PB}Lk6c00414 - PBac{PB}Lk6c04963 - PBac{PB}Lk6c05644 - PBac{RB}Lk6e02063 - PBac{RB}Lk6e03463 - PBac{WH}Lk6f01598
VDRC	v30389 w1118; P{GD3921}v30389 v32885 w1118; P{GD9353}v32885
	More stocks available...
Genomic Clones ( 1 )
	BACR11G22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 132 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD17393 LD31983 SD22574
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT01288 AT03162 AT03957 AT04588 AT07559 AT19936 AT20337 AT25920 GH10742 GH13161 GH28825 GM01634 GM02901 GM05529 GM09752 HL01159 HL01776 HL01818 HL02736 HL03045 HL04229 HL05460 HL06510 LD09989 LD10392 LD11630 LD11834 LD17668 LD17838 LD17930 LD20809 LD24879 LD26427 LD41183 LP02908 LP04213 LP20739 RE04741 RE08601 RE08768 RE32511 RE73122 RH68876 RH70537 SD02543 SD03742 SD06462 SD09050 SD10255 SD12702 SD16394 SD18396 SD18455 SD23085 SD23701 SD26713
Other clones	10013 16225 45801 51530 66770 76546 80890 106956 158302 161629 165677 173068 173210 191484 274157 280447 282355 282924 523663 557094 558034 569888 569984 572943 AT21338 CK01.9C.E8 CK01.46A.H12 CK01.64C.C10 CK01.73C.B8 CK01.85C.E9 CK01.122D.H8 CK01.168C.D3 Dmel_dig_002199_0672_2289 Dmel_dig_010784_0672_2628 Dmel_dig_016508_0588_2122 Dmel_dig_018816_0663_2945 Dmel_dig_019996_0583_2858 Dmel_neb_001381_0826_3722 Dmel_neb_007120_0685_2049 Dmel_neb_009368_0829_3269 EC051024 EC053036 EC053513 EK053432 EK057940 EK068904 EK109264 EK127851 EK158914 EK162415 EK164535 EK173113 EK194723 EK196506 EK213910 EK233901 EK261333 EK265211 EK270265 EK272748 EK294119 EK305453 EK308157 EN04048 EN12032 EN15821 EN16024 EN17545 FGM222F06 FGM310B07 FGM320E11 RE01011 UUGC0338
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0017581 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44672
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Lk6 anon-WO0172774.84 (FlyBase, 1996-) Source for merge of: Lk6 CG6929 CG17342 (Bayraktaroglu, 2000.4.17)
Additional comments	Source for merge of Lk6 anon-WO0172774.84 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	Lk6 controls eIF-4E phosphorylation and cannot act through nonphophorylatable eIF-4E. eIF-4E phosphorylation is dramatically reduced in Lk6 mutants. (Arquier et al., 2005) Lk6 controls eIF-4E phosphorylation. (Arquier et al., 2005) Lk6 is necessary for normal growth and development. (Arquier et al., 2005) Lk6 is dispensible for normal growth and development, but is required under conditions of reduced dietary protein and oxidative stress. (Reiling et al., 2005) Candidate for role in the regulation of longevity - as indicated by expression pattern of associated P{GawB}Lk6DJ634. (Seroude et al., 2002) Isolated from a Drosophila embryo cDNA library, using polyclonal mouse serum S5-45 (that was raised against Drosophila proteins that bind to microtubules in vitro) as a probe. (Kidd and Raff, 1997) An Lk6 cDNA has been cloned and sequenced. (Kidd and Raff, 1997)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_143729 NM_169423 RefSeq (Proteins) • NP_651986 NP_731624 DDBJ / EMBL / GenBank • AA951499 AAB18789 AAF54694 AAF54695 AQ025274 AQ073923 AQ254663 AW943107 AX260122 AY075405 BH740723 BZ286280 BZ665510 CL943608 CZ466441 CZ470151 CZ472705 CZ477034 CZ484063 U76378 Entrez Gene - A searchable database of RefSeq genes. • 44672 UniProtKB/TrEMBL • Q9VGI4 Q9VGI5 Q94548
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, ATP binding site (IPR017441) Protein kinase, catalytic domain (IPR000719) Serine/threonine-protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Serine/threonine-protein kinase-like domain (IPR017442)
Linkouts
	BioGRID - A database of protein and genetic interactions • 69194 DroID - A comprehensive database of gene and protein interactions. • FBgn0017581 DRSC - Results from RNAi screens. • FBgn0017581 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0017581 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17342-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0017581 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44672 InParanoid A subset of ortholog calls from InParanoid. • AAEL004704-PA Aedes aegypti (mosquito) XP_395927.3 Apis mellifera (honey bee) XP_001951545.1 Acyrthosiphon pisum (pea aphid) 266139 Branchiostoma floridae (lancelet) 281522 Branchiostoma floridae (lancelet) CPIJ003312 Culex pipens (mosquito) ENSCPOP00000013407 Cavia porcellus (guinea pig) 182721 Capitella spl (polychaete worm) LmjF19.0140 Leishmania major (virus) ENSMUSP00000095532 Mus musculus (house mouse) 93027 Nematostella vectensis (starlet anemone) PF11_0464 Plasmodium falciparum (protozoal parasite) YPL153C Saccharomyces cerevisiae (budding yeast) XP_779905.1 Strongylocentrotus purpuratus (purple sea urchin) Tc00.1047053511821.60 Trypanosoma cruzi (parasitic trypanosome) 24596 Thalassiosira pseudonana (marine diatom) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/lk6_mnk.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44672 modMine - Data generated by the modENCODE project. • FBgn0017581 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV50310 LH24496 ISCW015270 FBgn0227970 FBgn0213995 FBgn0197563 FBgn0192104 FBgn0180929 JGI_V11_306600 FBgn0074498 FBgn0149858 FBgn0149857 FBgn0146251 FBgn0126774 FBgn0109423 FBgn0093639 CPIJ003313 CPIJ003312 ACYPI006520 GB17530 AGAP003160 AAEL004704 PB24960 PHUM576840 GLEAN_10495
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	anon-WO0172774.84   CG6929   CG17342 (Reiling et al., 2005, Seroude et al., 2002, Brody et al., 2002, Morrison et al., 2000, Buszczak et al., 2007, Molnar et al., 2006, Perkins et al., 2009, Keleman et al., 2009.8.5, Ni et al., 2011.7.19) LK6 (Reiling et al., 2005, Raff, 1996.10.28, Gonzalez et al., 1998, Kidd and Raff, 1997, Nicholson et al., 2008, Molnar et al., 2006, Parra-Palau et al., 2005, Guenin et al., 2010) lk6 (Arquier et al., 2005, Dubruille et al., 2009) Lk6 (Gregory et al., 2007, Gronke et al., 2005, Buszczak et al., 2007, Slack et al., 2010, Arancio et al., 2010, Gan et al., 2010, Ayroles et al., 2009, Nuzhdin et al., 2009, Teleman et al., 2008) MESR8 (Huang and Rubin, 2000) MNK/LK6 (Morrison et al., 2000)
Name Synonym	Lk6
Secondary FlyBase IDs
	FBgn0037945 FBgn0037946 FBgn0046349
References ( 61 )
Generate a list of	All references relating to this gene ( 61 )
List References by type	Research paper  ( 29 ) Supplementary material  ( 5 ) Review  ( 1 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 3 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 4 ) Patent  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 4 )
	Arancio et al., 2010, Genetics 185(1): 129--140 The nucleosome remodeling factor ISWI functionally interacts with an evolutionarily conserved network of cellular factors. [FBrf0213976] Gan et al., 2010, Cell Res. 20(7): 763--783 Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq. [FBrf0211191] Guenin et al., 2010, BMC Genomics 11: 47 Expression profiling of prospero in the Drosophila larval chemosensory organ: Between growth and outgrowth. [FBrf0210012] Slack et al., 2010, PLoS Genet. 6(3): e1000881 Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk. [FBrf0210418] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...