FlyBase Gene Report: Dmel\klg

General Information

Symbol

Dmel\klg

Species

D. melanogaster

Name

klingon

Annotation Symbol

CG6669

Feature Type

protein_coding_gene

FlyBase ID

FBgn0017590

Gene Model Status

Current

Stock Availability

13 publicly available

Gene Summary

klingon (klg) encodes a homophilic cell adhesion molecule that is regulated by Notch signalling. It is involved in long term memory formation and photoreceptor cell commitment. [Date last reviewed: 2019-09-12] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

l(3)rN712

Key Links

Genomic Location

Cytogenetic map

94D3-94D4

Sequence location

3R:22,899,284..22,961,731 [+]

Recombination map

3-77

RefSeq locus

NT_033777 REGION:22899284..22961731

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (12 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables axon guidance receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN002895063

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (7 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

involved_in behavioral response to ethanol

inferred from mutant phenotype

(Berger et al., 2008)

involved_in homophilic cell adhesion via plasma membrane adhesion molecules

inferred from direct assay

(Butler et al., 1997)

involved_in long-term memory

inferred from mutant phenotype

(Akalal et al., 2011, Matsuno et al., 2009)

involved_in R7 cell differentiation

inferred from mutant phenotype

(Butler et al., 1997)

involved_in R7 cell fate commitment

inferred from genetic interaction with FLYBASE:Sos; FB:FBgn0001965, FLYBASE:sev; FB:FBgn0003366

(Butler et al., 1997)

NOT involved_in anesthesia-resistant memory

inferred from mutant phenotype

(Matsuno et al., 2009)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in homophilic cell adhesion via plasma membrane adhesion molecules

inferred from biological aspect of ancestor with PANTHER:PTN002895062

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in synapse organization

inferred from biological aspect of ancestor with PANTHER:PTN002895063

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

is_active_in axon

inferred from biological aspect of ancestor with PANTHER:PTN002895063

(assigned by GO_Central )

(Gaudet et al., 2011)

located_in extrinsic component of plasma membrane

inferred from sequence or structural similarity

(Butler et al., 1997)

is_active_in neuronal cell body

inferred from biological aspect of ancestor with PANTHER:PTN002895063

(assigned by GO_Central )

(Gaudet et al., 2011)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN002895062

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

KLINGON SUBFAMILY OF WIRINS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

KLINGON SUBFAMILY OF WIRINS -: Wirins are members of a widely distributed family of two- and three-Ig domain molecules that mediate axonal guidance, synapse targeting, and other neuronal wiring-related functions. The Klingon subfamily expanded within hexapods, resulting in four paralogs in D. melanogaster. (Adapted from FBrf0245249.)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\klg for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VCT4)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.49

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

klg-RA

FBtr0084337

NM_079730

4052

545

Additional Transcript Data and Comments

Reported size (kB)

6.0, 4.4 (northern blot)

(Butler et al., 1997)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

klg-PA

FBpp0083730

60.1

545

8.95

NP_524454

AAF56071

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

528 (aa)

(Butler et al., 1997)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\klg using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

klg_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 12 -- 17

presumptive embryonic/larval peripheral nervous system

(Butler et al., 1997)

neuron

(Butler et al., 1997)

presumptive embryonic/larval central nervous system | restricted

(Butler et al., 1997)

embryonic stage 13 -- 16

larval midline neuron

(Kearney et al., 2004)

third instar larval stage

photoreceptor cell R7

(Butler et al., 1997)

lamina anlage | restricted

(Butler et al., 1997)

eye disc | restricted

(Butler et al., 1997)

eye disc posterior to the morphogenetic furrow

(Butler et al., 1997)

pupal stage

photoreceptor cell R8

(Butler et al., 1997)

Additional Descriptive Data

Expression pattern inferred from unspecified enhancer trap line.

(Kearney et al., 2004)

klg transcripts are first expressed at embryonic stage 12 in the CNS. They are expressed at a high level in a limited number of neurons in the CNS and continue to be expressed through embyrogenesis and into larval stages. By stage 14, they are also expressed in a limited number of neurons of the external sensory organs in the PNS. In larvae, klg transcripts are expressed in the eye imaginal disc. Transient expression is observed in a band of cells three rows wide that is located about 4-5 rows behind the morphogenetic furrow. Expres ion is not detected in the next 2-3 rows but is then observed in multiple cells per ommatidial cluster. This resolves to expression in R7 only within three rows. R7 expression continues throughout the development of the eye. After pupariation, expression in R8 begins. klg is also expressed in a subset of neurons in the lamina in third instar larvae.

(Butler et al., 1997)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult CNS glial cell | subset

(Matsuno et al., 2015)

neuron | subset of adult brain

(Matsuno et al., 2015)

neuropil | surrounding

(Matsuno et al., 2015)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

klg surrounds the neuropils and partially overlaps with expression driven by Scer\GAL4^repo.PU and, separately, by Scer\GAL4^elav.PU.

(Matsuno et al., 2015)

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\klg in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\klg

View exonic expression by tissue for Dmel\klg

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42707/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0017590

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0017590

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0017590

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6669

Flygut - An atlas of the Drosophila adult midgut

FBgn0017590

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 22 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 10 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of klg

Transgenic constructs containing regulatory region of klg

Aberrations (Deficiencies and Duplications) ( 3 )

Inferred from experimentation ( 3 )

Gene not disrupted in

T(Y;3)R133

(BDGP Project Members, 1994-1999)

Gene disrupted in

Df(3R)Exel6193

(Ryder, 2004.4.26)

Df(3R)hh

(Butler et al., 1997)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | recessive

lethal - all die before end of larval stage | recessive

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

klg^GD2555

viable, with Scer\GAL4^Mef2.PR

klg^GD2555

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

viable (with klg^E226)

klg^GS10439

viable (with klg^GS10439)

klg^E226

Other Phenotypes

Allele

abnormal memory

klg^ruslan

abnormal memory, with Scer\GAL4^hs.PB

klg^GD14314

abnormal memory (with klg^E226)

abnormal memory (with klg^GS10439)

klg^E226

abnormal memory (with klg^ruslan)

klg^E226

abnormal memory | adult stage, with Scer\GAL4^elav.PU

abnormal memory | adult stage, with Scer\GAL4^nrv2.PU

abnormal memory | adult stage, with Scer\GAL4^repo.PU

klg^GD14314

abnormal memory | adult stage | RU486 conditional, with Scer\GAL4^{Atpα-GSG3285-1}

klg^GD14314

abnormal memory | adult stage | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

klg^GD14314

abnormal memory | recessive

klg^ruslan

chemical sensitive

klg^ruslan

long lived, with Scer\GAL4^hs.PB

klg^GS0009

some die during larval stage | recessive

Phenotype manifest in

Allele

ommatidium, with Scer\GAL4^elav-C155

klg^UAS.cBa

photoreceptor cell R7, with Scer\GAL4^elav-C155

klg^UAS.cBa

photoreceptor neuron, with Scer\GAL4^elav-C155

klg^UAS.cBa

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (23)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\IGLON5

3 of 15

Yes

Hsap\LSAMP

3 of 15

Yes

Hsap\NEGR1

3 of 15

Yes

Hsap\NTM

3 of 15

Yes

Hsap\OPCML

3 of 15

Yes

Hsap\DSCAM

1 of 15

Hsap\DSCAML1

1 of 15

Hsap\IGSF5

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Hsap\LRIT3

1 of 15

Yes

Hsap\MYOT

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (22)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Iglon5

3 of 15

Yes

Mmus\Lsamp

3 of 15

Yes

Mmus\Negr1

3 of 15

Yes

Mmus\Ntm

3 of 15

Yes

Mmus\Opcml

3 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Mmus\Lrit3

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (18)

Rnor\Iglon5

3 of 13

Yes

Rnor\Lsamp

3 of 13

Yes

Rnor\Ntm

3 of 13

Yes

Rnor\Opcml

3 of 13

Yes

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Xenopus tropicalis (Western clawed frog) (15)

Xtro\iglon5

3 of 12

Yes

Xtro\lsamp

3 of 12

Yes

Xtro\negr1

3 of 12

Yes

Xtro\ntm

3 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Xtro\ncam2

1 of 12

Xtro\opcml

1 of 12

Xtro\papln

1 of 12

Danio rerio (Zebrafish) (34)

Drer\negr1

4 of 15

Yes

3 of 15

3 of 15

3 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\lrit1b

1 of 15

Yes

Drer\lrit3a

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Drer\si:ch1073-459j12.1

1 of 15

Drer\si:dkeyp-75h12.2

1 of 15

Drer\ush2a

1 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (13)

Cele\wrk-1

11 of 15

Yes

Cele\rig-5

2 of 15

Cele\C53A5.13

1 of 15

Yes

Cele\igcm-2

1 of 15

Cele\lad-2

1 of 15

Cele\let-805

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (53)

Gene Symbol

Score

Source

Alignment

5 of 10

5 of 10

5 of 10

Ama

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

Lac

3 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

1 of 10

bdl

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

rst

1 of 10

sdk

1 of 10

Strn-Mlck

1 of 10

tutl

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

OPCML; opioid binding protein/cell adhesion molecule like

model of ovarian cancer

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

IGLON5; IgLON family member 5

3 of 15

618861

LSAMP; limbic system associated membrane protein

3 of 15

603241

NEGR1; neuronal growth regulator 1

3 of 15

613173

NTM; neurotrimin

3 of 15

607938

OPCML; opioid binding protein/cell adhesion molecule like

3 of 15

600632

OVARIAN CANCER

ovarian cancer

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

klg

bead aggregation assay, fluorescence microscopy, inferred by author, enzyme linked immunosorbent assay

(Ozkan et al., 2013, Butler et al., 1997)

klg - apolpp

cosedimentation, western blot

(Panakova et al., 2005)

klg - cDIP

enzyme linked immunosorbent assay

(Ozkan et al., 2013)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

klg

suppressible

repo

(Matsuno et al., 2015)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

klg

(Matsuno et al., 2009)

pbl

suppressible

klg

(Gregory et al., 2007)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

67656

DroID - A comprehensive database of gene and protein interactions.

FBgn0017590

MIST (protein-protein) - An integrated Molecular Interaction Database

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-77

Cytogenetic map

94D3-94D4

Sequence location

3R:22,899,284..22,961,731 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

94D3-94D4

Limits computationally determined from genome sequence between P{lacW}Gclm^L0580 and P{EP}hh^EP3521

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

94D1-94D13

(Butler, 1996.11.14)

94D1-94D4

(determined by in situ hybridisation)

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

94D-94D

(determined by in situ hybridisation)

(Butler et al., 1997)

94D-94D

(Butler, 1996.4.28)

Experimentally Determined Recombination Data

Location

3-77

(FlyBase, 2016)

3-79.0

(Comeron et al., 2012)

3-78.1

(Hiromi and Butler, 1997.3.8)

(Butler, 1996.11.14)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (13)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

25236

w¹¹¹⁸; Mi{ET1}klg^MB05977

28746

y¹ v¹; P{TRiP.JF03174}attP2

38584

y¹ w^*; Mi{MIC}klg^MI04822

12152

ry⁵⁰⁶ P{PZ}klg^rN712/TM3, Sb¹

82486

y¹ sc^* v¹ sev²¹; P{WKO.1-B8}attP40

82549

y¹ sc^* v¹ sev²¹; P{WKO.P1-F11}attP40

35967

y¹ w^*; Mi{MIC}klg^MI02135/TM3, Sb¹ Ser¹

44739

y¹ w^*; Mi{MIC}klg^MI08080/TM3, Sb¹ Ser¹

Kyoto

104158

w^*; P{GawB}klg^NP2325 / TM3, Sb¹ Ser¹

202288

y¹ w^67c23; P{GSV6}klg^GS10056/TM3, Sb¹ Ser¹

VDRC

v102502

P{KK111830}VIE-260B

v108818

P{KK109706}VIE-260B

More stocks available...

Genomic Clones (49)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (70)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0017590

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0017590

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

42707

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Matsuno et al., 2015, Matsuno et al., 2009, Butler et al., 1997)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: klg l(3)rN712

(Spradling et al., 1999)

Additional comments

Other Comments

The genomic organisation of klg has been determined, and its expression pattern has been analysed.

(Butler et al., 1997)

klg is expressed in a pattern indistinguishable from that of the enhancer trap line P{HZ}klg^H214. klg is a member of the immunoglobulin (Ig) domain superfamily. Recessive lethal mutations in klg have been recovered that fail to complement E(sev)3D.

(Butler et al., 1994)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 46 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

42707

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VCT4

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VCT4

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0017590

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42707/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0017590

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

klg_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0017590

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0017590

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6669

Flygut - An atlas of the Drosophila adult midgut

FBgn0017590

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

42707

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG6669

MARRVEL_MODEL - MARRVEL (model organism gene)

42707

modMine - A data warehouse for the modENCODE project

FBgn0017590

Linkouts

BioGRID - A database of protein and genetic interactions.

67656

DroID - A comprehensive database of gene and protein interactions.

FBgn0017590

DRSC - Results frm RNAi screens

FBgn0017590

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0017590

FlyMine - An integrated database for Drosophila genomics

FBgn0017590

MIST (protein-protein) - An integrated Molecular Interaction Database

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

CG6669

(Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Seong et al., 2001)

CT20712

(Hynes and Zhao, 2000)

Klg

(Bittern et al., 2021, Yang et al., 2008)

h214

l(3)rN712

(Meister and Braun, 1995.10, BDGP Project Members, 1994-1999)

Name Synonyms

Klingon

(Zhang et al., 2013, Morey et al., 2008, Ganguly-Fitzgerald et al., 2006)

klingon

(Eguchi et al., 2013, Yoshioka et al., 2012, Edwards et al., 2009, Matsuno et al., 2009, Berger et al., 2008, Firth and Baker, 2007, Gregory et al., 2007, Burnette et al., 2005, Butler et al., 1997, Butler, 1996.11.14)

ruslan

(Berger et al., 2008)

Secondary FlyBase IDs