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Gene Dsim\amd
| General Information | ||||||||
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| Symbol | Dsim\amd | Species | D. simulans | |||||
| Name | α methyl dopa-resistant | Annotation symbol | GD24184 | |||||
| Feature type | protein_coding_gene | FlyBase ID | FBgn0018304 | |||||
| Gene Model Status | Current | Stock availability | None publicly available | |||||
| Genomic Location | ||||||||
| Chromosome (arm) | 2L | Recombination map | ||||||
| Cytogenetic map | Sequence location | 2L:18,806,716..18,810,416 [+] | ||||||
Genomic Maps | 
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 Summary Information | ||||||||
| Automatically generated summary
See sections below for more information | The gene α methyl dopa-resistant is referred to in FlyBase by the symbol Dsim\amd (GD24184, FBgn0018304). It is a protein_coding_gene from Drosophila simulans. Based on sequence similarity, it is predicted to have molecular function: carboxy-lyase activity. Based on sequence similarity, it is predicted to be involved in the biological process: chitin-based cuticle development; catecholamine metabolic process. No alleles are reported. It has one annotated transcript and one annotated polypeptide. Protein features are: Aromatic-L-amino-acid decarboxylase; Pyridoxal phosphate-dependent decarboxylase; Pyridoxal phosphate-dependent transferase; Pyridoxal phosphate-dependent transferase, major region, subdomain 1; Pyridoxal phosphate-dependent transferase, major region, subdomain 2; Pyridoxal-phosphate binding site. Gene sequence location is 2L:18806716..18810416. | |||||||
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Recent Updates
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| Description |
What does this section display?
This section contains items that were added to this record for each release.
It currently only tracks new links between this FlyBase report and other
FlyBase data classes (e.g. genes, references, stocks) or controlled
vocabulary terms (e.g. GO, anatomy terms).
What does this section not display?
This section does not currently display links that were removed or gene model changes.
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| FB2013_03 | ||||||||
| FB2013_02 | ||||||||
| All updates | Click here to see a list of all updates to this record from FB2010_08 and on. | |||||||
| Detailed Mapping Data | ||||||||
| FlyBase Computed Cytological Location | ||||||||
Cytogenetic map Evidence for location | ||||||||
| Experimentally Determined Cytological Location | ||||||||
Cytogenetic map Notes References | ||||||||
| Experimentally Determined Recombination Data | ||||||||
| Location | ||||||||
| Left of (cM) | ||||||||
| Right of (cM) | ||||||||
| Notes | ||||||||
| Gene Model & Products | ||||||||
Please see the
GBrowse view of
Dsim\amd for information on other features  To submit a correction to a
gene model please use the Contact
FlyBase form 
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| Comments on Gene Model | ||||||||
| Transcript Data | ||||||||
| Annotated Transcripts | ||||||||
Name FlyBase ID RefSeq ID Length (nt) Associated CDS
(aa) FBtr0224094
1533
510 | ||||||||
| Additional Transcript Data & Comments | ||||||||
| Reported size (kB) | ||||||||
| Comments | ||||||||
| External Data | ||||||||
| Crossreferences | ||||||||
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Polypeptide Data | ||||||||
| Annotated Polypeptides | ||||||||
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein FBpp0222586 57.0 510
5.83 | ||||||||
| Additional Polypeptide Data & Comments | ||||||||
| Reported size (kDa) | ||||||||
| Comments | ||||||||
| External Data | ||||||||
| Linkouts | ||||||||
| Crossreferences | InterPro
domains - A database of protein families, domains, and functional sites
• Pyridoxal phosphate-dependent decarboxylase (IPR002129)
Aromatic-L-amino-acid decarboxylase (IPR010977)
Pyridoxal phosphate-dependent transferase (IPR015424)
Pyridoxal-phosphate binding site (IPR021115)
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| Sequences Consistent with the Gene Model
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| DDBJ / EMBL / GenBank | DNA sequence Protein
sequence Name | |||||||
| UniProtKB/Swiss-Prot | ||||||||
| UniProtKB/TrEMBL | ||||||||
| Mapped Features | ||||||||
Mapped Features have been reorganized, please
see this article for details. Additional mapped features and mutations can
be found on GBrowse or related reports. Type Symbol &
Location Additional Notes References | ||||||||
| External Data | ||||||||
| Linkouts | ||||||||
| Crossreferences | ||||||||
| Expression Data | ||||||||
| Transcript Expression | ||||||||
| Additional Descriptive Data | ||||||||
| Marker for | ||||||||
| Subcellular Localization | ||||||||
| CV Term | ||||||||
| Polypeptide Expression | ||||||||
| Additional Descriptive Data | ||||||||
| Marker for | ||||||||
| Subcellular Localization (GO Cellular Component) | ||||||||
CV term References | ||||||||
| Expression Deduced from Reporters | ||||||||
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High-Throughput Expression Data
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| Associated Tools | ||||||||
| Reference |
See Gelbart and Emmert, 2010.10.13
for analysis details and data files for all genes.
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FlyAtlas Anatomy Microarray
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modENCODE Anatomy RNA-Seq
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modENCODE Development RNA-Seq
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modENCODE Cell Lines RNA-Seq
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modENCODE Treatments RNA-Seq
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Expression Clusters
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External Data & Images
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| Linkouts | ||||||||
| Alleles & Phenotypes | ||||||||
| Summary of Allele Phenotypes | ||||||||
Phenotype manifest
in Allele | ||||||||
| Classical Alleles ( 0 ) | ||||||||
| For All Classical Alleles Show | ||||||||
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| Alleles Carried on Transgenic Constructs
( 0 ) | ||||||||
| For All Alleles Carried on Transgenic Constructs Show | ||||||||
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| Aneuploid Aberrations | ||||||||
| Transgenic Constructs & Insertions
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| Transgenic Constructs | ||||||||
Type of
construct Name Expression
data | ||||||||
| Insertions | ||||||||
Type of insertions Name Expression
data | ||||||||
| Gene Ontology: Function, Process
& Cellular Component ( 5 unique terms ) | ||||||||
There is no information supporting a cellular component term for this gene. (Based on a review of available data before: 2006) | ||||||||
| Terms Based on
Experimental Evidence ( 0 terms ) | ||||||||
| Terms Based on Predictions or
Assertions ( 5 terms ) | ||||||||
| Molecular Function | ||||||||
CV term References | ||||||||
inferred from sequence or structural similarity with UniProtKB:P18486 | ||||||||
| Biological Process | ||||||||
CV term References | ||||||||
inferred from sequence or structural similarity with UniProtKB:P18486 inferred from electronic annotation with InterPro:IPR010977 inferred from sequence or structural similarity with UniProtKB:P18486 | ||||||||
| Cellular Component ( 0 terms) | ||||||||
| Sequence Ontology: Class of Gene | ||||||||
| Interactions & Pathways | ||||||||
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Summary of Physical Interactions
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| Summary of Genetic Interactions | ||||||||
| Interacts with | Please look at the allele data
for full details of the genetic interactions Dsim\amd allele Gene References | |||||||
| External Data | ||||||||
| Linkouts | ||||||||
| Orthologs
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OrthoDB Orthologs (1)
- based on analysis using Dmel annotation version 5.41
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| OrthoDB Ortholog Groups | ||||||||
OrthoDB orthology group searches Drosophila inclusive ortholog search Dipteran inclusive ortholog search Insect inclusive ortholog search Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search | ||||||||
| Ortholog(s) in Drosophila melanogaster
(EOG6XPR1Q)
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Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group | ||||||||
| Human Orthologs (0) | ||||||||
Gene OMIM HGNC | ||||||||
| AAA Orthologs (1)
based on analysis using Dmel annotation version 4.3
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Organism Gene Drosophila melanogaster | ||||||||
| Stocks & Reagents | ||||||||
| Stocks Listed in FlyBase ( 0 ) | ||||||||
| Genomic Clones ( 0 ) | ||||||||
| cDNA Clones ( 0 ) | ||||||||
This section lists
cDNAs and ESTs that fall within the genomic extent
of the gene model, which may include cDNAs and ESTs
of genes within introns, or of overlapping genes.
Please see GBrowse for alignment of the cDNAs and ESTs
to the gene model. | ||||||||
| cDNA Clones, Fully Sequenced | ||||||||
| BDGP DGC clones | ||||||||
| Other clones | ||||||||
| cDNA Clones, End Sequenced (ESTs) | ||||||||
| BDGP DGC clones | ||||||||
| Other clones | ||||||||
| RNAi & Array Information | ||||||||
| Linkouts | ||||||||
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Antibody Information
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| Other Information | ||||||||
| Discoverer | ||||||||
| Etymology | ||||||||
| Identification | ||||||||
| Relationship to Other Genes | ||||||||
| Source for database identity of | ||||||||
| Source for database merge of | ||||||||
| Additional comments | ||||||||
| Other Comments | ||||||||
To evaluate the extent of qualitative changes in amd gene expression, patterns of expression in D.melanogaster, D.simulans and D.virilis strains are compared. Three general conclusions can be made. First, some functions are conserved in all three species. Second, amd expression often precedes the apparent time the function is needed. Third, completely novel patterns of amd expression can appear (or disappear) rapidly in these species in the absence of apparent function. | ||||||||
| External Crossreferences & Linkouts
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| Sequence Crossreferences | ||||||||
RefSeq (Transcripts) RefSeq (Proteins) Entrez Gene
- A searchable database of RefSeq genes.
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| Other Crossreferences | ||||||||
InterPro
domains - A database of protein families, domains, and functional sites
• Pyridoxal phosphate-dependent decarboxylase (IPR002129)
Aromatic-L-amino-acid decarboxylase (IPR010977)
Pyridoxal phosphate-dependent transferase (IPR015424)
Pyridoxal-phosphate binding site (IPR021115)
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| Linkouts | ||||||||
FlyMine
- Integrated genomics database for Drosophila, Anopheles, and C.elegans
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| Synonyms & Secondary IDs
( 5 ) | ||||||||
| Reported As | ||||||||
| Symbol Synonym | CG10501 dsim_GLEANR_7906 Dsim\amd | |||||||
| Name Synonym | α methyl dopa-resistant | |||||||
| Secondary FlyBase IDs | ||||||||
| References ( 10 ) | ||||||||
| Research paper |
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| Personal communication to FlyBase |
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| FlyBase analysis |
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| Protein sequence record |
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| Letter |
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