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Gene Dpse\SR

General Information
Symbol	Dpse\SR	Species	D. pseudoobscura pseudoobscura
Name	Sex Ratio	Annotation symbol
Feature type	gene	FlyBase ID	FBgn0018576
Gene Model Status	Unannotated	Stock availability	None publicly available
Also Known As	SR
Genomic Location
Chromosome (arm)		Recombination map
Cytogenetic map		Sequence location
Summary Information
Automatically generated summary See sections below for more information	The gene Sex Ratio is referred to in FlyBase by the symbol Dpse\SR (FBgn0018576). It is a gene from Drosophila pseudoobscura pseudoobscura. Its molecular function is unknown. The biological processes in which it is involved are not known. 2 alleles are reported. No phenotypic data is available. It has no annotated transcripts. Gene has not been localized to the genome sequence.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa)
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Mapped Features
Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
modENCODE Anatomy RNA-Seq
modENCODE Development RNA-Seq
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
Expression Clusters
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of Dpse\SR Class Mutagen Stocks Known lesion Dpse\SR1 natural population 0 -- Dpse\SRunspecified 0 Yes
Alleles Carried on Transgenic Constructs ( 0 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Dpse\SR Class Mutagen Stocks Known lesion
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Dpse\SR allele Gene References
External Data
Linkouts
Orthologs
OrthoDB Orthologs (0) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search No orthologs identified Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Ortholog(s) in Drosophila melanogaster (None identified)
No D. melanogaster orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 0 )
Genomic Clones ( 0 )
cDNA Clones ( 0 )
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi & Array Information
Linkouts
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	The Dpse\SR X chromosome. when present in males, causes an increased rate of sex chromosome loss but no increase in frequency of diplo-XY sperm. (Cobbs, 1992) Study of the frequency of autosomal aneuploid sperm demonstrates high rates of autosomal aneuploidy are not restricted to chromosome 3 but also occur for chromosomes 2, 4 and 5. The overall frequency of autosomal aneuploid sperm is estimated to be approximately 50%. Microscopic studies of meiosis in testes indicated meiotic nondisjunction and meiotic chromosome loss are responsible for the mutant phenotype. (Cobbs et al., 1991) Dpse\SR exhibits both discrete and continuous variation. Discrete variation is caused by X-chromosome meiotic drive. Results conclude there is some evidence for slight distortion of sex-chromosome segregation ratios, the genetic basis of the distortion and its relevance to natural populations remains unknown. (Curtsinger, 1991)
External Crossreferences & Linkouts
Sequence Crossreferences
Other Crossreferences
Linkouts
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	Dpse\SR   SR (Price et al., 2010, Price et al., 2008)
Name Synonym	Sex Ratio   sex ratio (Price et al., 2008)
Secondary FlyBase IDs
References ( 16 )
Research paper	Price et al., 2010, Evolution 64(5): 1504--1509 Sex ratio drive promotes sexual conflict and sexual coevolution in the fly Drosophila pseudoobscura. [FBrf0211063] Price et al., 2008, Science 322(5905): 1241--1243 Selfish genetic elements promote polyandry in a fly. [FBrf0206343] Taylor and Jaenike, 2002, Genetics 160: 1721--1731 Sperm competition and the dynamics of X chromosome drive: stability and extinction. [FBrf0159664] Salceda, 2001, D. I. S. 84: 95--99 Inversion polymorphism of Drosophila pseudoobscura (Drosophilidae) from the Baja California peninsula. [FBrf0150720] Kelly and Wade, 2000, J. Theor. Biol. 204(1): 83--101 Molecular evolution near a two-locus balanced polymorphism. [FBrf0127490] Kovacevic and Schaeffer, 2000, Genetics 156(1): 155--172 Molecular population genetics of X-linked genes in Drosophila pseudoobscura. [FBrf0129909] Beckenbach, 1996, Evolution 50(2): 787--794 Selection and the 'Sex-Ratio' polymorphism in natural populations of Drosophila pseudoobscura. [FBrf0086899] Gebhardt and Anderson, 1993, Genet. Res. (Camb.) 62(1): 63--75 Temperature related fertility selection on body size and the sex-ratio gene arrangement in Drosophila pseudoobscura. [FBrf0058551] Cobbs, 1992, J. Hered. 83(2): 81--84 Sex chromosome loss induced by the 'Sex-Ratio' trait in Drosophila pseudoobscura males. [FBrf0056521] Beckenbach, 1991, Am. Nat. 137(3): 340--343 Sex-ratio polymorphism in Drosophila pseudoobscura. [FBrf0053144] Cobbs et al., 1991, Genetics 127: 381--390 Male-Sex-Ratio trait in Drosophila pseudoobscura: frequency of autosomal aneuploid sperm. [FBrf0054149] Curtsinger, 1991, Am. Nat. 137(3): 344--348 X-chromosome segregation distortion in Drosophila. [FBrf0053145] Sturtevant and Dobzhansky, 1936, Genetics 21: 473--490 Geographical distribution and cytology of 'sex ratio' in Drosophila pseudoobscura and related species. [FBrf0003534]
Review	de Carvalho and Vaz, 1999, Heredity 83(3): 221--228 Are Drosophila SR drive chromosomes always balanced? [FBrf0111340] Powell, 1992, Krimbas, Powell, 1992: 73--126 Inversion polymorphism in Drosophila pseudoobscura and Drosophila persimilis. [FBrf0090307] Lyttle, 1991, A. Rev. Genet. 25: 511--557 Segregation distorters. [FBrf0053109]