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Gene Dmel\CoVa

General Information
Symbol	Dmel\CoVa	Species	D. melanogaster
Name	Cytochrome c oxidase subunit Va	Annotation symbol	CG14724
Feature type	protein_coding_gene	FlyBase ID	FBgn0019624
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	tend, COX, Va
Genomic Location
Chromosome (arm)	3R	Recombination map	3-
Cytogenetic map	86F9-86F9	Sequence location	3R:7,645,081..7,646,021 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Cytochrome c oxidase subunit Va is referred to in FlyBase by the symbol Dmel\CoVa (CG14724, FBgn0019624). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: cytochrome-c oxidase activity. There is experimental evidence that it is involved in the biological process: positive regulation of cell cycle. 8 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; mesothoracic tergum. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Cytochrome c oxidase, subunit Va. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of very high expression. Peak expression observed during early larval stages, during late pupal stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1639962_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of CoVa. Gene sequence location is 3R:7645081..7646021.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Ren et al., 2010, Biochem. Biophys. Res. Commun. 401(1): 64--68 Sequence features BKN41234 HFA16611
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 86F9-86F9   Limits computationally determined from genome sequence between P{EP}Lk6EP886 and P{PZ}svp07842
Experimentally Determined Cytological Location
Cytogenetic map Notes References 86F1-87A10     (Caggese, 1996.10.24) 86F8-86F11   (determined by in situ hybridisation)   (Caggese et al., 1999)
Experimentally Determined Recombination Data
Location	3- (Caggese, 1996.10.24)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CoVa for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CoVa-RA FBtr0082473  NM_057869   730   149 CoVa-RB FBtr0082474  NM_169436   663   149
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CoVa-PA   FBpp0081947   16.6   149   5.35     NP_477217   AAF54706 CoVa-PB   FBpp0081948   16.6   149   5.35     NP_731641   AAN13534
Additional Polypeptide Data & Comments
Reported size (kDa)	149 (aa) (Caggese et al., 1999)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Cytochrome c oxidase, subunit Va (IPR003204) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME14724
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA696965   AE014297 AAF54706   AE014297 AAN13534   AC008307   AI064553   AI106637   AI108846   AI114117   AI135336   AI293015   AI386844   AI405369   AI517098   AX093911   BE976387   BE978640   BF489282   BF489398   BI163680   BI167486   BI353120   BI353251   BI354213   BI354214   BI356429   BI356538   BI364200   BI365785   BI366856   BI374795   BI375202   BI375331   BI563535   BI565385   BI565415   BI565628   BI566046   BI566355   BI566444   BI566462   BI566495   BI567198   BI567231   BI567511   BI568333   BI571490   BI572626   BI572688   BI573958   BI573959   BI574498   BI574813   BI575465   BI575993   BI580918   BI582723   BI582801   BI583197   BI584144   BI585190   BI585582   BI586418   BI588055   BI588343   BI588675   BI589182   BI591123   BI591432   BI591926   BI592201   BI592357   BI592566   BI604570   BI606313   BI606658   BI607089   BI607313   BI607542   BI607593   BI607665   BI607917   BI609322   BI610161   BI610849   BI610992   BI610995   BI614769   BI615103   BI615193   BI615790   BI616310   BI617417   BI618143   BI620626   BI620876   BI621250   BI622462   BI622517   BI623399   BI623531   BI623539   BI623722   BI623893   BI624450   BI624507   BI624907   BI625332   BI625382   BI625849   BI626103   BI626339   BI626562   BI627520   BI628591   BI629689   BI629808   BI630098   BI630413   BI630891   BI631824   BI631943   BI634167   BP548520   BP550190   BP550191   BP551217   BP551218   BP552234   BP552235   BP552697   BP552698   BP554058   BP554059   BP554839   BP554840   BP559797   BP559798   BP560253   BP560254   BT011037   CO181732   CO182878   CO192460   CO262094   CO269960   CO287616   CO303370   CO309948   CO329498   CO332321   EC077092   EC196132   EC208003   EC225044   EC229086   EC231740   EC239734   EC250674   EL877400   EL877478   EL877479   EL877558   EL878403   EL878404   EL880632   EV574930   EV575502   EV579268   EV579282   EV580204   EV580404   EV580445   EV580468   EV581195   EV582871   EV583113   EV584589   EV585131   EV585413   EV585515   EV585976   EV588513   EV588729   EV594259   EV595252   EV599675   GH774446   GH790179   GH851390   GH852990   GH853448   GH863213   GH893216   GH900503   GH906588   GH913003   Y09065
UniProtKB/Swiss-Prot	Q94514
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Dorus et al., 2006, Wasbrough et al., 2010) day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0019624    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0019624 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of very high expression. Peak expression observed during early larval stages, during late pupal stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0019624 expression level Developmental Stage   Expression Level embryo 00-02hr    27252 embryo 02-04hr    35063 embryo 04-06hr    34346 embryo 06-08hr    35278 embryo 08-10hr    36376 embryo 10-12hr    66952 embryo 12-14hr    36745 embryo 14-16hr    47706 embryo 16-18hr    49504 embryo 18-20hr    66208 embryo 20-22hr    72695 embryo 22-24hr    66210 larva L1    100627 larva L2    101492 larva L3 12hr old    83361 larva L3 puffstage 1-2    57115 larva L3 puffstage 3-6    26992 larva L3 puffstage 7-9    20393 white prepupae new    18674 white prepupae 12hr    19059 white prepupae 24hr    18088 pupae 2d postWPP    38433 pupae 3d postWPP    105906 pupae 4d postWPP    164907 adult male 01day    148073 adult male 05day    101571 adult male 30day    59087 adult female 01day    132571 adult female 05day    47176 adult female 30day    34714 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (27252) embryo 02-04hr  (35063) embryo 04-06hr  (34346) embryo 06-08hr  (35278) embryo 08-10hr  (36376) embryo 10-12hr  (66952) embryo 12-14hr  (36745) embryo 14-16hr  (47706) embryo 16-18hr  (49504) embryo 18-20hr  (66208) embryo 20-22hr  (72695) embryo 22-24hr  (66210) larva L1  (100627) larva L2  (101492) larva L3 12hr old  (83361) larva L3 puffstage 1-2  (57115) larva L3 puffstage 3-6  (26992) larva L3 puffstage 7-9  (20393) white prepupae new  (18674) white prepupae 12hr  (19059) white prepupae 24hr  (18088) pupae 2d postWPP  (38433) pupae 3d postWPP  (105906) pupae 4d postWPP  (164907) adult male 01day  (148073) adult male 05day  (101571) adult male 30day  (59087) adult female 01day  (132571) adult female 05day  (47176) adult female 30day  (34714) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (27252) embryo 02-04hr  (35063) embryo 04-06hr  (34346) embryo 06-08hr  (35278) embryo 08-10hr  (36376) embryo 10-12hr  (66952) embryo 12-14hr  (36745) embryo 14-16hr  (47706) embryo 16-18hr  (49504) embryo 18-20hr  (66208) embryo 20-22hr  (72695) embryo 22-24hr  (66210) larva L1  (100627) larva L2  (101492) larva L3 12hr old  (83361) larva L3 puffstage 1-2  (57115) larva L3 puffstage 3-6  (26992) larva L3 puffstage 7-9  (20393) white prepupae new  (18674) white prepupae 12hr  (19059) white prepupae 24hr  (18088) pupae 2d postWPP  (38433) pupae 3d postWPP  (105906) pupae 4d postWPP  (164907) adult male 01day  (148073) adult male 05day  (101571) adult male 30day  (59087) adult female 01day  (132571) adult female 05day  (47176) adult female 30day  (34714) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (27252) embryo 02-04hr  (35063) embryo 04-06hr  (34346) embryo 06-08hr  (35278) embryo 08-10hr  (36376) embryo 10-12hr  (66952) embryo 12-14hr  (36745) embryo 14-16hr  (47706) embryo 16-18hr  (49504) embryo 18-20hr  (66208) embryo 20-22hr  (72695) embryo 22-24hr  (66210) larva L1  (100627) larva L2  (101492) larva L3 12hr old  (83361) larva L3 puffstage 1-2  (57115) larva L3 puffstage 3-6  (26992) larva L3 puffstage 7-9  (20393) white prepupae new  (18674) white prepupae 12hr  (19059) white prepupae 24hr  (18088) pupae 2d postWPP  (38433) pupae 3d postWPP  (105906) pupae 4d postWPP  (164907) adult male 01day  (148073) adult male 05day  (101571) adult male 30day  (59087) adult female 01day  (132571) adult female 05day  (47176) adult female 30day  (34714) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    27252 embryo 02-04hr    35063 embryo 04-06hr    34346 embryo 06-08hr    35278 embryo 08-10hr    36376 embryo 10-12hr    66952 embryo 12-14hr    36745 embryo 14-16hr    47706 embryo 16-18hr    49504 embryo 18-20hr    66208 embryo 20-22hr    72695 embryo 22-24hr    66210 larva L1    100627 larva L2    101492 larva L3 12hr old    83361 larva L3 puffstage 1-2    57115 larva L3 puffstage 3-6    26992 larva L3 puffstage 7-9    20393 white prepupae new    18674 white prepupae 12hr    19059 white prepupae 24hr    18088 pupae 2d postWPP    38433 pupae 3d postWPP    105906 pupae 4d postWPP    164907 adult male 01day    148073 adult male 05day    101571 adult male 30day    59087 adult female 01day    132571 adult female 05day    47176 adult female 30day    34714 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0019624 expression level Developmental Stage   Expression Level embryo 00-02hr    27252 embryo 02-04hr    35063 embryo 04-06hr    34346 embryo 06-08hr    35278 embryo 08-10hr    36376 embryo 10-12hr    66952 embryo 12-14hr    36745 embryo 14-16hr    47706 embryo 16-18hr    49504 embryo 18-20hr    66208 embryo 20-22hr    72695 embryo 22-24hr    66210 larva L1    100627 larva L2    101492 larva L3 12hr old    83361 larva L3 puffstage 1-2    57115 larva L3 puffstage 3-6    26992 larva L3 puffstage 7-9    20393 white prepupae new    18674 white prepupae 12hr    19059 white prepupae 24hr    18088 pupae 2d postWPP    38433 pupae 3d postWPP    105906 pupae 4d postWPP    164907 adult male 01day    148073 adult male 05day    101571 adult male 30day    59087 adult female 01day    132571 adult female 05day    47176 adult female 30day    34714 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (27252) embryo 02-04hr  (35063) embryo 04-06hr  (34346) embryo 06-08hr  (35278) embryo 08-10hr  (36376) embryo 10-12hr  (66952) embryo 12-14hr  (36745) embryo 14-16hr  (47706) embryo 16-18hr  (49504) embryo 18-20hr  (66208) embryo 20-22hr  (72695) embryo 22-24hr  (66210) larva L1  (100627) larva L2  (101492) larva L3 12hr old  (83361) larva L3 puffstage 1-2  (57115) larva L3 puffstage 3-6  (26992) larva L3 puffstage 7-9  (20393) white prepupae new  (18674) white prepupae 12hr  (19059) white prepupae 24hr  (18088) pupae 2d postWPP  (38433) pupae 3d postWPP  (105906) pupae 4d postWPP  (164907) adult male 01day  (148073) adult male 05day  (101571) adult male 30day  (59087) adult female 01day  (132571) adult female 05day  (47176) adult female 30day  (34714) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (27252) embryo 02-04hr  (35063) embryo 04-06hr  (34346) embryo 06-08hr  (35278) embryo 08-10hr  (36376) embryo 10-12hr  (66952) embryo 12-14hr  (36745) embryo 14-16hr  (47706) embryo 16-18hr  (49504) embryo 18-20hr  (66208) embryo 20-22hr  (72695) embryo 22-24hr  (66210) larva L1  (100627) larva L2  (101492) larva L3 12hr old  (83361) larva L3 puffstage 1-2  (57115) larva L3 puffstage 3-6  (26992) larva L3 puffstage 7-9  (20393) white prepupae new  (18674) white prepupae 12hr  (19059) white prepupae 24hr  (18088) pupae 2d postWPP  (38433) pupae 3d postWPP  (105906) pupae 4d postWPP  (164907) adult male 01day  (148073) adult male 05day  (101571) adult male 30day  (59087) adult female 01day  (132571) adult female 05day  (47176) adult female 30day  (34714) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (27252) embryo 02-04hr  (35063) embryo 04-06hr  (34346) embryo 06-08hr  (35278) embryo 08-10hr  (36376) embryo 10-12hr  (66952) embryo 12-14hr  (36745) embryo 14-16hr  (47706) embryo 16-18hr  (49504) embryo 18-20hr  (66208) embryo 20-22hr  (72695) embryo 22-24hr  (66210) larva L1  (100627) larva L2  (101492) larva L3 12hr old  (83361) larva L3 puffstage 1-2  (57115) larva L3 puffstage 3-6  (26992) larva L3 puffstage 7-9  20393 white prepupae new  18674 white prepupae 12hr  19059 white prepupae 24hr  18088 pupae 2d postWPP  (38433) pupae 3d postWPP  (105906) pupae 4d postWPP  (164907) adult male 01day  (148073) adult male 05day  (101571) adult male 30day  (59087) adult female 01day  (132571) adult female 05day  (47176) adult female 30day  (34714) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    27252 embryo 02-04hr    35063 embryo 04-06hr    34346 embryo 06-08hr    35278 embryo 08-10hr    36376 embryo 10-12hr    66952 embryo 12-14hr    36745 embryo 14-16hr    47706 embryo 16-18hr    49504 embryo 18-20hr    66208 embryo 20-22hr    72695 embryo 22-24hr    66210 larva L1    100627 larva L2    101492 larva L3 12hr old    83361 larva L3 puffstage 1-2    57115 larva L3 puffstage 3-6    26992 larva L3 puffstage 7-9    20393 white prepupae new    18674 white prepupae 12hr    19059 white prepupae 24hr    18088 pupae 2d postWPP    38433 pupae 3d postWPP    105906 pupae 4d postWPP    164907 adult male 01day    148073 adult male 05day    101571 adult male 30day    59087 adult female 01day    132571 adult female 05day    47176 adult female 30day    34714 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0019624    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0019624 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0019624 expression level Tissue   Expression Level Larval Central Nervous System    1388.475 Larval Midgut    2650 Larval Hindgut    2960.8 Larval Malpighian Tubules    2155.3 Larval Fat Body    953.7 Larval Salivary Gland    2077.3 Larval Trachea    1613.425 Larval Carcass    2857.7 Adult Head    2926 Adult Eye    3709.375 Adult Brain    2328.3 Adult Thoracic-Abdominal Ganglion    3108.2 Adult Crop    2450 Adult Midgut    2767.5 Adult Hindgut    3607.6 Adult Malpighian Tubules    2719 Adult Fat Body    3085.7 Adult Salivary Gland    2508.3 Adult Heart    3825.875 Adult VirginFemale Spermatheca    2954.1 Adult InseminatedFemale Spermatheca    2782.6 Adult Ovary    1142 Adult Testis    963.6 Adult Male Accessory Gland    1156.1 Adult Carcass    4894.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1388.475) Larval Midgut  (2650) Larval Hindgut  (2960.8) Larval Malpighian Tubules  (2155.3) Larval Fat Body  (953.7) Larval Salivary Gland  (2077.3) Larval Trachea  (1613.425) Larval Carcass  (2857.7) Adult Head  (2926) Adult Eye  (3709.375) Adult Brain  (2328.3) Adult Thoracic-Abdominal Ganglion  (3108.2) Adult Crop  (2450) Adult Midgut  (2767.5) Adult Hindgut  (3607.6) Adult Malpighian Tubules  (2719) Adult Fat Body  (3085.7) Adult Salivary Gland  (2508.3) Adult Heart  (3825.875) Adult VirginFemale Spermatheca  (2954.1) Adult InseminatedFemale Spermatheca  (2782.6) Adult Ovary  (1142) Adult Testis  (963.6) Adult Male Accessory Gland  (1156.1) Adult Carcass  (4894.6) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (1388.475) Larval Midgut  (2650) Larval Hindgut  (2960.8) Larval Malpighian Tubules  (2155.3) Larval Fat Body    953.7 Larval Salivary Gland  (2077.3) Larval Trachea  (1613.425) Larval Carcass  (2857.7) Adult Head  (2926) Adult Eye  (3709.375) Adult Brain  (2328.3) Adult Thoracic-Abdominal Ganglion  (3108.2) Adult Crop  (2450) Adult Midgut  (2767.5) Adult Hindgut  (3607.6) Adult Malpighian Tubules  (2719) Adult Fat Body  (3085.7) Adult Salivary Gland  (2508.3) Adult Heart  (3825.875) Adult VirginFemale Spermatheca  (2954.1) Adult InseminatedFemale Spermatheca  (2782.6) Adult Ovary  (1142) Adult Testis    963.6 Adult Male Accessory Gland  (1156.1) Adult Carcass  (4894.6) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1388.475 Larval Midgut    2650 Larval Hindgut    2960.8 Larval Malpighian Tubules    2155.3 Larval Fat Body    953.7 Larval Salivary Gland    2077.3 Larval Trachea    1613.425 Larval Carcass    2857.7 Adult Head    2926 Adult Eye    3709.375 Adult Brain    2328.3 Adult Thoracic-Abdominal Ganglion    3108.2 Adult Crop    2450 Adult Midgut    2767.5 Adult Hindgut    3607.6 Adult Malpighian Tubules    2719 Adult Fat Body    3085.7 Adult Salivary Gland    2508.3 Adult Heart    3825.875 Adult VirginFemale Spermatheca    2954.1 Adult InseminatedFemale Spermatheca    2782.6 Adult Ovary    1142 Adult Testis    963.6 Adult Male Accessory Gland    1156.1 Adult Carcass    4894.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0019624 expression level Tissue   Expression Level Larval Central Nervous System    1388.475 Larval Midgut    2650 Larval Hindgut    2960.8 Larval Malpighian Tubules    2155.3 Larval Fat Body    953.7 Larval Salivary Gland    2077.3 Larval Trachea    1613.425 Larval Carcass    2857.7 Adult Head    2926 Adult Eye    3709.375 Adult Brain    2328.3 Adult Thoracic-Abdominal Ganglion    3108.2 Adult Crop    2450 Adult Midgut    2767.5 Adult Hindgut    3607.6 Adult Malpighian Tubules    2719 Adult Fat Body    3085.7 Adult Salivary Gland    2508.3 Adult Heart    3825.875 Adult VirginFemale Spermatheca    2954.1 Adult InseminatedFemale Spermatheca    2782.6 Adult Ovary    1142 Adult Testis    963.6 Adult Male Accessory Gland    1156.1 Adult Carcass    4894.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1388.475) Larval Midgut  (2650) Larval Hindgut  (2960.8) Larval Malpighian Tubules  (2155.3) Larval Fat Body  (953.7) Larval Salivary Gland  (2077.3) Larval Trachea  (1613.425) Larval Carcass  (2857.7) Adult Head  (2926) Adult Eye  (3709.375) Adult Brain  (2328.3) Adult Thoracic-Abdominal Ganglion  (3108.2) Adult Crop  (2450) Adult Midgut  (2767.5) Adult Hindgut  (3607.6) Adult Malpighian Tubules  (2719) Adult Fat Body  (3085.7) Adult Salivary Gland  (2508.3) Adult Heart  (3825.875) Adult VirginFemale Spermatheca  (2954.1) Adult InseminatedFemale Spermatheca  (2782.6) Adult Ovary  (1142) Adult Testis  (963.6) Adult Male Accessory Gland  (1156.1) Adult Carcass  (4894.6) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  1388.475 Larval Midgut  (2650) Larval Hindgut  (2960.8) Larval Malpighian Tubules  (2155.3) Larval Fat Body    953.7 Larval Salivary Gland  (2077.3) Larval Trachea  1613.425 Larval Carcass  (2857.7) Adult Head  (2926) Adult Eye  (3709.375) Adult Brain  (2328.3) Adult Thoracic-Abdominal Ganglion  (3108.2) Adult Crop  (2450) Adult Midgut  (2767.5) Adult Hindgut  (3607.6) Adult Malpighian Tubules  (2719) Adult Fat Body  (3085.7) Adult Salivary Gland  (2508.3) Adult Heart  (3825.875) Adult VirginFemale Spermatheca  (2954.1) Adult InseminatedFemale Spermatheca  (2782.6) Adult Ovary  1142 Adult Testis    963.6 Adult Male Accessory Gland  1156.1 Adult Carcass  (4894.6) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1388.475 Larval Midgut    2650 Larval Hindgut    2960.8 Larval Malpighian Tubules    2155.3 Larval Fat Body    953.7 Larval Salivary Gland    2077.3 Larval Trachea    1613.425 Larval Carcass    2857.7 Adult Head    2926 Adult Eye    3709.375 Adult Brain    2328.3 Adult Thoracic-Abdominal Ganglion    3108.2 Adult Crop    2450 Adult Midgut    2767.5 Adult Hindgut    3607.6 Adult Malpighian Tubules    2719 Adult Fat Body    3085.7 Adult Salivary Gland    2508.3 Adult Heart    3825.875 Adult VirginFemale Spermatheca    2954.1 Adult InseminatedFemale Spermatheca    2782.6 Adult Ovary    1142 Adult Testis    963.6 Adult Male Accessory Gland    1156.1 Adult Carcass    4894.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    2926   NA  Eye    3709.375   NA  Brain    2328.3   1388.475  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    3108.2   NA  Crop    2450   2650  Midgut    2767.5   2960.8  Hindgut    3607.6   2155.3  Malpighian Tubules    2719   953.7  Fat Body    3085.7   2077.3  Salivary Gland    2508.3   NA  Heart    3825.875   1613.425  Trachea    NA   NA  VirginFemale Spermatheca    2954.1   NA  InseminatedFemale Spermatheca    2782.6   NA  Ovary    1142   NA  Testis    963.6   NA  Male Accessory Gland    1156.1   2857.7  Carcass    4894.6 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_15
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0019624 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14724-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | recessive CoVatend semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 CoVaGD5167 Other Phenotypes Allele body color defective, with Scer\GAL4pnr-MD237 CoVaGD5167 mitotic cell cycle defective CoVadsRNA.cMa mitotic cell cycle defective | somatic clone CoVatend visible, with Scer\GAL4pnr-MD237 CoVaGD5167 visible | recessive | somatic clone CoVaJP785 Phenotype manifest in Allele cone cell | somatic clone CoVatend eye | somatic clone CoVaJP785 CoVatend eye disc | somatic clone CoVaJP785 eye disc posterior to the morphogenetic furrow | somatic clone CoVatend lens | somatic clone CoVatend mesothoracic tergum, with Scer\GAL4pnr-MD237 CoVaGD5167 ommatidial precursor cluster | somatic clone CoVatend trichogen cell, with Scer\GAL4pnr-MD237 CoVaGD5167
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of CoVa Class Mutagen Stocks Known lesion CoVaG16946 P-element activity 1 -- CoVatend ethyl methanesulfonate 1 Yes CoVaJP785 ethyl methanesulfonate 0 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CoVa Class Mutagen Stocks Known lesion CoVaGD5167 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CoVaJF02700 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CoVa+t1.925 in vitro construct - genomic fragment 0 Yes CoVadsRNA.cMa in vitro construct - RNAi 0 Yes CoVaKK115466 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel7310 (Ryder, 2004.4.26) Df(3R)M-Kx1 (Szeged Stock Center, 1998-) Df(3R)ry506-85C (Szeged Stock Center, 1998-)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD5167} NA P{KK115466} NA P{TRiP.JF02700} NA characterization construct P{CoVa+t1.925} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}CoVaG16946 NA
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
positive regulation of cell cycle inferred from mutant phenotype (Mandal et al., 2005)
Cellular Component
CV term Evidence References
lipid particle inferred from direct assay (Beller et al., 2006, Cermelli et al., 2006)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
cytochrome-c oxidase activity inferred from sequence or structural similarity with UniProtKB:P11240 (FlyBase, 1992-) inferred from sequence or structural similarity with UniProtKB:P20674 (Sardiello et al., 2003.6.11) non-traceable author statement (Caggese, 1996.10.24, Swiss-Prot Project Members, 1999.12.15)
Biological Process
CV term Evidence References
mitochondrial electron transport, cytochrome c to oxygen inferred from sequence or structural similarity with UniProtKB:P20674 (Sardiello et al., 2003.6.11)
Cellular Component
CV term Evidence References
mitochondrial inner membrane non-traceable author statement (Swiss-Prot Project Members, 1999.12.15) mitochondrial respiratory chain complex IV inferred from sequence or structural similarity with UniProtKB:P11240 (FlyBase, 1992-) inferred from sequence or structural similarity with UniProtKB:P20674 (Sardiello et al., 2003.6.11) non-traceable author statement (Caggese, 1996.10.24)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CoVa allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66552 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0019624 DroID - A comprehensive database of gene and protein interactions. • FBgn0019624 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41432
Orthologs
Genome-wide drosophilid orthologs	Dana\GF23167 Dere\GG18466 Dgri\GH18193 Dmoj\GI10146 Dper\GL12282 Dpse\GA13206 Dsec\GM23980 Dsim\CoVa Dvir\GJ23365 Dwil\GK14516 Dyak\GE24204
Curated drosophilid orthologs	Dpse\GA13206 (Tripoli et al., 2005) Dsim\CoVa
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL014944-PA Aedes aegypti (mosquito) AGAP011159-PA Anopheles gambiae (mosquito) XP_392368.1 Apis mellifera (honey bee) XP_001946089.1 Acyrthosiphon pisum (pea aphid) 22167 Batrachochytrium dendrobatidis (chytrid fungus) 132147 Branchiostoma floridae (lancelet) XP_001893767.1 Brugia malayi (roundworm nematode) BGIBMGA005793-PA Bombyx mori (silk worm) ENSBTAP00000022949 Bos taurus (bovine) CAF0006913 Candida albicans (a form of yeast) CN18022 Caenorhabditis brenneri (small nematode) CBP10033 Caenorhabditis briggsae (nematode) CE20218 Caenorhabditis elegans (worm) ENSCAFP00000026558 Canis familiaris (dog) CAGL0J00429g Candida glabrata (haploid yeast) JA02155 Caenorhabditis japonica (nematode) cn02222 Cryptococcus neoformans (yeast-like fungus) CPIJ008200 Culex pipens (mosquito) ENSCPOP00000019902 Cavia porcellus (guinea pig) RP07732 Caenorhabditis remanei (nematode) 159268 Capitella spl (polychaete worm) DEHA2E20658g Debaryomyces Hansenii (yeast) 55751 Daphnia pulex (daphnia) ENSDARP00000025342 Danio rerio (zebra fish) ENSDARP00000027159 Danio rerio (zebra fish) ENSECAP00000000106 Equus caballus (horse) ENSGACP00000008613 Gymnopilus aculeatus (mushroom) ENSGALP00000022815 Gallus gallus (chicken) 70304 Hypsipyla robusta (cedar shoot borer) ENSP00000317780 Homo sapiens (human) ISCW008682-PA Ixodes scapularis (deer tick) KLLA0F21890g Kluyveromyces lactis (yeast) 157909 Lottia gigantea (owl limpet) 9557 Monocosta brevicollis (choanoflagellate) ENSMODP00000011471 Monodelphis domestica (gray opossum) ENSMMUP00000015328 Macaca mulatta (rhesus monkey) ENSMUSP00000000090 Mus musculus (house mouse) 175253 Nematostella vectensis (starlet anemone) XP_001607639.1 Nasonia vitripennis (wasp) ENSOANP00000010425 Ornithorynchus anatinus (platypus) ENSORLP00000018491 Oryzias latipes (japanese killifish) PHUM005615-PA Pediculus humanus (human body louse) PP28155 Pristionchus pacificus (nematode) ENSPPYP00000006149 Pongo pygmaeus (orangutan) ENSPPYP00000007546 Pongo pygmaeus (orangutan) ENSPTRP00000012474 Pan troglodytes (chimpanzee) ENSRNOP00000025525 Rattus norvegicus (norway rat) YHR051W Saccharomyces cerevisiae (budding yeast) Smp_148800 Schistosoma mansoni (trematode parasite) SPAC1B2.04 Schizosaccharomyces pombe (fission yeast) XP_784558.1 Strongylocentrotus purpuratus (purple sea urchin) 22356 Trichoplax adhaerens (metazoa) XP_970156.1 Tribolium castaneum (red flour beetle) ENSTNIP00000019138 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000043761 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000045679 Xenopus tropicalis (frog) YALI0E10144g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB14641 NV12777 LH23400 ISCW008682 FBgn0241335 FBgn0216522 FBgn0210466 FBgn0067172 FBgn0178845 JGI_V11_55751 FBgn0073243 FBgn0149889 FBgn0132912 FBgn0125661 FBgn0110679 FBgn0100161 CPIJ008200 BGIBMGA005793 ACYPI007006 GB15816 AGAP011159 AAEL014944 AAEL011406 PHUM477570 GLEAN_09255 GLEAN_01862
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	27548 y1 v1; P{TRiP.JF02700}attP2 33291 w1118; P{EP}CoVaG16946/TM6C, Sb1 33839 w*; P{neoFRT}82B CoVatend/TM6B, Tb1
VDRC	v44490 w1118; P{GD5167}v44490
Genomic Clones ( 1 )
	BACR03D22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 181 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE42582
Other clones	DPiM_RE42582
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT25240 AT25513 GH05011 GH06704 GH08142 GH10803 GH13026 GH16077 GH17177 GH25350 GH27731 GM08812 GM22292 GM22855 GM26855 GM26858 RE03141 RE07867 RE42715 RE49264 RE51164 RE52482 RE62470 RE63026 RE63111 RE75166 RH04841 RH06623 RH08213 RH08292 RH08680 RH09837 RH10018 RH10288 RH12015 RH14086 RH16801 RH17050 RH17053 RH21020 RH21212 RH21734 RH23118 RH24275 RH24682 RH25191 RH26362 RH27050 RH29526 RH30074 RH31533 RH32436 RH34181 RH35144 RH35573 RH35688 RH36012 RH36057 RH37062 RH37117 RH37387 RH37924 RH39757 RH44234 RH44638 RH44765 RH45548 RH46220 RH47747 RH51811 RH52127 RH52563 RH54352 RH54405 RH55639 RH55824 RH55836 RH56051 RH56253 RH57063 RH58591 RH58724 RH59064 RH59452 RH60231 RH61473 RH61630 RH63185 RH63430 RH64013 RH64073 RH64647 RH65674 RH66642 RH67034 RH67541 RH68861 RH69984 RH72627 RH73270 RH74082 RH74356 RH74630 RH74686 RH74769
Other clones	97637 121487 190722 275351 bs50a09 bs81b01 CK01.11B.H8 CK01.83A.D5 CK01.99C.G2 CK01.126C.C7 Dmel_dig_001446_0673_3727 Dmel_dig_002465_0587_3708 Dmel_dig_003531_0674_0552 Dmel_dig_007250_0659_1049 Dmel_dig_008153_0660_1670 Dmel_dig_010746_0653_3308 Dmel_dig_010809_0615_2585 Dmel_dig_013149_0668_3132 Dmel_dig_013922_0591_3284 Dmel_dig_015172_0599_1531 Dmel_dig_015749_0666_1437 Dmel_dig_017919_0661_1954 Dmel_dig_018377_0594_2423 Dmel_dig_018430_0702_2992 Dmel_dig_018751_0681_1266 Dmel_dig_020808_0722_0909 Dmel_neb_009876_0915_0483 Dmel_neb_013625_0175_1740 Dmel_neb_013916_0704_1320 Dmel_neb_014365_0186_3464 Dmel_neb_015610_0643_1101 EC14888 EC24211 EC33785 EK066315 EK084357 EK097012 EK220016 EK241214 EK292960 EK303143 FGH128F07 FGM105G07 FGM211F07 FGM217F02 FGM220C04 FGM227G06 FGM232A05 FGM323A03 FGM325E06 IP07344 IP07444 IP07544 IP08258 IP10479 RH05208 RH09405 RH15102 RH29065 RH31132 RH48711 RH63149 RH65774 RH66346 RP003026010 RP003032263 RP003044737 RP003115856 RP003134961 RP003175372 RP003208936 RP003293405 RP003479768 RP003612920
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0019624 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41432
Antibody Information
	polyclonal (Ren et al., 2010)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	FBti0009814 (P{lacW}gloS011046) previously thought to map to CoVa actually maps to glo transcription unit, outwith the region of overlap with CoVa. (Das, 2002.7.3) Area matching Drosophila cytochrome c oxidase subunit Va preprotein gene, Acc. No. Y09065. Probable intron. (Davies, 2001.3.15) FlyBase curator comment: Insertion FBti0009814, 'S011046', stated to map to CoVa since flanking sequence extends to CoVa transcription unit. Release 3 annotation places FBti0009814 insertion site 5' to CoVa and within glo. (Deak, 1999.12.22) Cytochrome C gene identified solely by homology of the coding sequence to genes from other organisms. FlyBase curator comment: Insertion FBti0009814, 'S011046', stated to map to CoVa, however release 3 annotation places FBti0009814 insertion site 5' to CoVa and within glo. (Deak et al., 1997)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057869 NM_169436 RefSeq (Proteins) • NP_477217 NP_731641 DDBJ / EMBL / GenBank • AAF54706 AAN13534 AC008307 AX093911 BI356429 CAA70286 Y09065 Entrez Gene - A searchable database of RefSeq genes. • 41432 UniProtKB/Swiss-Prot • Q94514
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Cytochrome c oxidase, subunit Va (IPR003204) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME14724
Linkouts
	BioGRID - A database of protein and genetic interactions • 66552 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0019624 DroID - A comprehensive database of gene and protein interactions. • FBgn0019624 DRSC - Results from RNAi screens. • FBgn0019624 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0019624 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14724-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0019624 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41432 InParanoid A subset of ortholog calls from InParanoid. • AAEL014944-PA Aedes aegypti (mosquito) AGAP011159-PA Anopheles gambiae (mosquito) XP_392368.1 Apis mellifera (honey bee) XP_001946089.1 Acyrthosiphon pisum (pea aphid) 22167 Batrachochytrium dendrobatidis (chytrid fungus) 132147 Branchiostoma floridae (lancelet) XP_001893767.1 Brugia malayi (roundworm nematode) BGIBMGA005793-PA Bombyx mori (silk worm) ENSBTAP00000022949 Bos taurus (bovine) CAF0006913 Candida albicans (a form of yeast) CN18022 Caenorhabditis brenneri (small nematode) CBP10033 Caenorhabditis briggsae (nematode) CE20218 Caenorhabditis elegans (worm) ENSCAFP00000026558 Canis familiaris (dog) CAGL0J00429g Candida glabrata (haploid yeast) JA02155 Caenorhabditis japonica (nematode) cn02222 Cryptococcus neoformans (yeast-like fungus) CPIJ008200 Culex pipens (mosquito) ENSCPOP00000019902 Cavia porcellus (guinea pig) RP07732 Caenorhabditis remanei (nematode) 159268 Capitella spl (polychaete worm) DEHA2E20658g Debaryomyces Hansenii (yeast) 55751 Daphnia pulex (daphnia) ENSDARP00000025342 Danio rerio (zebra fish) ENSDARP00000027159 Danio rerio (zebra fish) ENSECAP00000000106 Equus caballus (horse) ENSGACP00000008613 Gymnopilus aculeatus (mushroom) ENSGALP00000022815 Gallus gallus (chicken) 70304 Hypsipyla robusta (cedar shoot borer) ENSP00000317780 Homo sapiens (human) ISCW008682-PA Ixodes scapularis (deer tick) KLLA0F21890g Kluyveromyces lactis (yeast) 157909 Lottia gigantea (owl limpet) 9557 Monocosta brevicollis (choanoflagellate) ENSMODP00000011471 Monodelphis domestica (gray opossum) ENSMMUP00000015328 Macaca mulatta (rhesus monkey) ENSMUSP00000000090 Mus musculus (house mouse) 175253 Nematostella vectensis (starlet anemone) XP_001607639.1 Nasonia vitripennis (wasp) ENSOANP00000010425 Ornithorynchus anatinus (platypus) ENSORLP00000018491 Oryzias latipes (japanese killifish) PHUM005615-PA Pediculus humanus (human body louse) PP28155 Pristionchus pacificus (nematode) ENSPPYP00000006149 Pongo pygmaeus (orangutan) ENSPPYP00000007546 Pongo pygmaeus (orangutan) ENSPTRP00000012474 Pan troglodytes (chimpanzee) ENSRNOP00000025525 Rattus norvegicus (norway rat) YHR051W Saccharomyces cerevisiae (budding yeast) Smp_148800 Schistosoma mansoni (trematode parasite) SPAC1B2.04 Schizosaccharomyces pombe (fission yeast) XP_784558.1 Strongylocentrotus purpuratus (purple sea urchin) 22356 Trichoplax adhaerens (metazoa) XP_970156.1 Tribolium castaneum (red flour beetle) ENSTNIP00000019138 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000043761 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000045679 Xenopus tropicalis (frog) YALI0E10144g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41432 modMine - Data generated by the modENCODE project. • FBgn0019624 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB14641 NV12777 LH23400 ISCW008682 FBgn0241335 FBgn0216522 FBgn0210466 FBgn0067172 FBgn0178845 JGI_V11_55751 FBgn0073243 FBgn0149889 FBgn0132912 FBgn0125661 FBgn0110679 FBgn0100161 CPIJ008200 BGIBMGA005793 ACYPI007006 GB15816 AGAP011159 AAEL014944 AAEL011406 PHUM477570 GLEAN_09255 GLEAN_01862
Synonyms & Secondary IDs ( 16 )
Reported As
Symbol Synonym	CG14724 (Cermelli et al., 2006, Kalifa et al., 2006, Porcelli et al., 2007, Perkins et al., 2009, Tiefenböck et al., 2010, Keleman et al., 2009.8.5, Cammarato et al., 2011) CoVa (Beller et al., 2006, Mandal et al., 2007, McBride et al., 2006, Liao et al., 2006, Cermelli et al., 2006, Kalifa et al., 2006, Dorus et al., 2006, Tripoli et al., 2005, Owusu-Ansah et al., 2008, Tiefenböck et al., 2010, Mandal et al., 2010, Porcelli et al., 2010, Curtis et al., 2007, Wasbrough et al., 2010) COX (Walker and Benzer, 2004, Maier et al., 2001) COXA_DROME (Storm and Sonnhammer, 2003) tend (Liao et al., 2006, Mandal et al., 2005, Mirouse et al., 2007) Va (Szuplewski and Terracol, 2001, Ren et al., 2010)
Name Synonym	Cytochrome c oxidase Polypeptide Va (Tripoli et al., 2005) cytochrome c oxidase subunit Va (Caggese, 1996.10.24, Liao et al., 2006, Cermelli et al., 2006) Cytochrome c oxidase subunit Va (Cammarato et al., 2011) cytochrome C oxidase subunit Va (Mandal et al., 2010) cytochrome-c oxidase subunit Va (Curtis et al., 2007) Cytochrome c oxidase Va (Porcelli et al., 2007) cytochrome oxidase subunit Va (McBride et al., 2006) Cytochrome oxidase Va (Mandal et al., 2007) Subunit Va (Ren et al., 2010) tenured (Liao et al., 2006, Mandal et al., 2005, Mirouse et al., 2007)
Secondary FlyBase IDs
	FBgn0023019
References ( 54 )
Generate a list of	All references relating to this gene ( 54 )
List References by type	Research paper  ( 23 ) Supplementary material  ( 8 ) Review  ( 1 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 2 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 2 ) Patent  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 2 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 ) Letter  ( 1 )
Recent research papers ( 5 )
	Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Mandal et al., 2010, J. Cell Biol. 188(4): 473--479 Metabolic control of G1-S transition: cyclin E degradation by p53-induced activation of the ubiquitin-proteasome system. [FBrf0210063] Porcelli et al., 2010, Mitochondrion 10(5): 433--448 Genetic, functional and evolutionary characterization of scox, the Drosophila melanogaster ortholog of the human SCO1 gene. [FBrf0211481] Ren et al., 2010, Biochem. Biophys. Res. Commun. 401(1): 64--68 Cytochrome c oxidase loses catalytic activity and structural integrity during the aging process in Drosophila melanogaster. [FBrf0212016] Tiefenböck et al., 2010, EMBO J. 29(1): 171--183 The Drosophila PGC-1 homologue Spargel coordinates mitochondrial activity to insulin signalling. [FBrf0209639] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...