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Gene Dmel\ATPsyn-b

General Information
Symbol	Dmel\ATPsyn-b	Species	D. melanogaster
Name	ATP synthase, subunit b	Annotation symbol	CG8189
Feature type	protein_coding_gene	FlyBase ID	FBgn0019644
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map	3-
Cytogenetic map	67C5-67C5	Sequence location	3L:9,723,099..9,724,324 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene ATP synthase, subunit b is referred to in FlyBase by the symbol Dmel\ATPsyn-b (CG8189, FBgn0019644). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: hydrogen-exporting ATPase activity, phosphorylative mechanism. There is experimental evidence that it is involved in the biological process: phagocytosis, engulfment. 5 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; mesothoracic tergum. It has one annotated transcript and one annotated polypeptide. Protein features are: ATPase, F0 complex, B chain/subunit B; ATPase, F0 complex, B chain/subunit B/MI25. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of very high expression. Peak expression observed during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1628573_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of ATPsyn-b. Gene sequence location is 3L:9723099..9724324.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02	Controlled Vocabulary Terms hydrogen ion transporting ATP synthase activity, rotational mechanism
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 67C5-67C5   Limits computationally determined from genome sequence between P{PZ}fry02240 and P{lacW}l(3)L0539L0539&P{PZ}Dhh1rL562
Experimentally Determined Cytological Location
Cytogenetic map Notes References 67C1-67C11     (Caggese, 1996.10.21) 67C9-67C11   (determined by in situ hybridisation)   (Caggese et al., 1999)
Experimentally Determined Recombination Data
Location	3- (Caggese, 1996.10.21)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\ATPsyn-b for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45 Low-frequency RNA-seq exon junction(s) not annotated. DGC clone GM13038 appears problematic: unspliced intron
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) ATPsyn-b-RA FBtr0076405  NM_079287   918   243
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein ATPsyn-b-PA   FBpp0076134   27.4   243   9.04     NP_524011   AAF50212
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • ATPase, F0 complex, B chain/subunit B/MI25 (IPR008688) ATPase, F0 complex, B chain/subunit B (IPR013837) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME08189
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201558   AA695233   AA697916   AA801802   AA802929   AA803943   AA821239   AA821241   AE014296 AAF50212   AI062411   AI063760   AI064229   AI114036   AI134495   AI134617   AI134921   AI238211   AI258739   AI259271   AI293484   AI293504   AI293727   AI297861   AI389655   AI402247   AI404919   AI405129   AI406164   AI543379   AI944911   AW941364   BE976884   BE978208   BF488476   BF488998   BF495861   BF496460   BF501585   BF504237   BF504549   BF504742   BF506353   BG632665   BG634354   BG635185   BG639019   BG640712   BI163121   BI163517   BI169365   BI172624   BI228485   BI228859   BI229699   BI229715   BI230044   BI230451   BI234129   BI235686   BI239879   BI240615   BI354225   BI354281   BI358653   BI358680   BI358695   BI358699   BI358717   BI364277   BI364511   BI365860   BI369078   BI372987   BI563794   BI564939   BI565114   BI565408   BI566693   BI568677   BI569417   BI569418   BI569841   BI572177   BI574417   BI576549   BI577024   BI582488   BI582728   BI583313   BI583363   BI584254   BI584555   BI584597   BI586498   BI588094   BI588135   BI588630   BI589562   BI589585   BI589890   BI590260   BI590469   BI592029   BI592718   BI604631   BI604752   BI605827   BI606430   BI608916   BI609145   BI609720   BI609759   BI611061   BI611134   BI611206   BI611357   BI611432   BI612861   BI612970   BI614615   BI614955   BI616408   BI618841   BI619265   BI619296   BI619693   BI620328   BI621973   BI622818   BI623236   BI625291   BI627288   BI627328   BI627791   BI628139   BI628536   BI629170   BI630092   BI631840   BI631849   BI634600   BI637487   BP548007   BP555708   BP557305   BT004878 AAO45234   BT011453   BX051178   BX066019   CK657399   CL527721   CO186601   CO187498   CO191715   CO267992   CO272528   CO277632   CO294117   CO337709   EC056674   EC066150   EC068856   EC085935   EC090978   EC197834   EC197905   EC201376   EC206530   EC208510   EC238834   EC240950   EC247989   EC266152   EL870205   EL877623   EV580710   EV583005   EV584641   EV586782   EV587680   EV588854   EV589473   EV591212   EV595434   EV597320   GH756080   GH778767   GH796293   GH798408   GH799734   GH801018   GH802250   GH805811   GH811276   GH812051   GH812701   GH817183   GH817997   GH819256   GH819534   GH821020   GH822489   GH824706   GH827872   GH827884   GH832873   GH837446   GH838278   GH839533   GH840815   GH844636   GH845418   GH847404   GH848589   GH849514   GH850997   GH854043   GH857949   GH860266   GH862503   GH863047   GH867413   GH868747   GH876596   GH881802   GH885392   GH885676   GH888138   GH888147   GH888904   GH896764   GH903259   GH903378   GH907070   GH909883   GH912886   GH919697   GH922033   GH925067   GH926211   GH931772   GH938237   GH939245   GH942347   Y08967 CAA70164
UniProtKB/Swiss-Prot	Q94516
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Dorus et al., 2006, Wasbrough et al., 2010) day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
lipid particle inferred from direct assay (Beller et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1330.55 Larval Midgut    2864.3 Larval Hindgut    3015.7 Larval Malpighian Tubules    1766.6 Larval Fat Body    756.6 Larval Salivary Gland    2837.3 Larval Trachea    1989.8 Larval Carcass    2974.625 Adult Head    2610 Adult Eye    3603.125 Adult Brain    2210.8 Adult Thoracic-Abdominal Ganglion    2829.5 Adult Crop    2032.9 Adult Midgut    2514.9 Adult Hindgut    3639.2 Adult Malpighian Tubules    3071.3 Adult Fat Body    3220 Adult Salivary Gland    6434.3 Adult Heart    3908.35 Adult VirginFemale Spermatheca    3145.6 Adult InseminatedFemale Spermatheca    3018.9 Adult Ovary    1120.2 Adult Testis    1274.3 Adult Male Accessory Gland    2497.5 Adult Carcass    4512.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1330.55) Larval Midgut  (2864.3) Larval Hindgut  (3015.7) Larval Malpighian Tubules  (1766.6) Larval Fat Body  (756.6) Larval Salivary Gland  (2837.3) Larval Trachea  (1989.8) Larval Carcass  (2974.625) Adult Head  (2610) Adult Eye  (3603.125) Adult Brain  (2210.8) Adult Thoracic-Abdominal Ganglion  (2829.5) Adult Crop  (2032.9) Adult Midgut  (2514.9) Adult Hindgut  (3639.2) Adult Malpighian Tubules  (3071.3) Adult Fat Body  (3220) Adult Salivary Gland  (6434.3) Adult Heart  (3908.35) Adult VirginFemale Spermatheca  (3145.6) Adult InseminatedFemale Spermatheca  (3018.9) Adult Ovary  (1120.2) Adult Testis  (1274.3) Adult Male Accessory Gland  (2497.5) Adult Carcass  (4512.3) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (1330.55) Larval Midgut  (2864.3) Larval Hindgut  (3015.7) Larval Malpighian Tubules  (1766.6) Larval Fat Body    756.6 Larval Salivary Gland  (2837.3) Larval Trachea  (1989.8) Larval Carcass  (2974.625) Adult Head  (2610) Adult Eye  (3603.125) Adult Brain  (2210.8) Adult Thoracic-Abdominal Ganglion  (2829.5) Adult Crop  (2032.9) Adult Midgut  (2514.9) Adult Hindgut  (3639.2) Adult Malpighian Tubules  (3071.3) Adult Fat Body  (3220) Adult Salivary Gland  (6434.3) Adult Heart  (3908.35) Adult VirginFemale Spermatheca  (3145.6) Adult InseminatedFemale Spermatheca  (3018.9) Adult Ovary  (1120.2) Adult Testis  (1274.3) Adult Male Accessory Gland  (2497.5) Adult Carcass  (4512.3) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1330.55 Larval Midgut    2864.3 Larval Hindgut    3015.7 Larval Malpighian Tubules    1766.6 Larval Fat Body    756.6 Larval Salivary Gland    2837.3 Larval Trachea    1989.8 Larval Carcass    2974.625 Adult Head    2610 Adult Eye    3603.125 Adult Brain    2210.8 Adult Thoracic-Abdominal Ganglion    2829.5 Adult Crop    2032.9 Adult Midgut    2514.9 Adult Hindgut    3639.2 Adult Malpighian Tubules    3071.3 Adult Fat Body    3220 Adult Salivary Gland    6434.3 Adult Heart    3908.35 Adult VirginFemale Spermatheca    3145.6 Adult InseminatedFemale Spermatheca    3018.9 Adult Ovary    1120.2 Adult Testis    1274.3 Adult Male Accessory Gland    2497.5 Adult Carcass    4512.3 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1330.55 Larval Midgut    2864.3 Larval Hindgut    3015.7 Larval Malpighian Tubules    1766.6 Larval Fat Body    756.6 Larval Salivary Gland    2837.3 Larval Trachea    1989.8 Larval Carcass    2974.625 Adult Head    2610 Adult Eye    3603.125 Adult Brain    2210.8 Adult Thoracic-Abdominal Ganglion    2829.5 Adult Crop    2032.9 Adult Midgut    2514.9 Adult Hindgut    3639.2 Adult Malpighian Tubules    3071.3 Adult Fat Body    3220 Adult Salivary Gland    6434.3 Adult Heart    3908.35 Adult VirginFemale Spermatheca    3145.6 Adult InseminatedFemale Spermatheca    3018.9 Adult Ovary    1120.2 Adult Testis    1274.3 Adult Male Accessory Gland    2497.5 Adult Carcass    4512.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1330.55) Larval Midgut  (2864.3) Larval Hindgut  (3015.7) Larval Malpighian Tubules  (1766.6) Larval Fat Body  756.6 Larval Salivary Gland  (2837.3) Larval Trachea  (1989.8) Larval Carcass  (2974.625) Adult Head  (2610) Adult Eye  (3603.125) Adult Brain  (2210.8) Adult Thoracic-Abdominal Ganglion  (2829.5) Adult Crop  (2032.9) Adult Midgut  (2514.9) Adult Hindgut  (3639.2) Adult Malpighian Tubules  (3071.3) Adult Fat Body  (3220) Adult Salivary Gland  (6434.3) Adult Heart  (3908.35) Adult VirginFemale Spermatheca  (3145.6) Adult InseminatedFemale Spermatheca  (3018.9) Adult Ovary  (1120.2) Adult Testis  (1274.3) Adult Male Accessory Gland  (2497.5) Adult Carcass  (4512.3) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  1330.55 Larval Midgut  (2864.3) Larval Hindgut  (3015.7) Larval Malpighian Tubules  (1766.6) Larval Fat Body    756.6 Larval Salivary Gland  (2837.3) Larval Trachea  (1989.8) Larval Carcass  (2974.625) Adult Head  (2610) Adult Eye  (3603.125) Adult Brain  (2210.8) Adult Thoracic-Abdominal Ganglion  (2829.5) Adult Crop  (2032.9) Adult Midgut  (2514.9) Adult Hindgut  (3639.2) Adult Malpighian Tubules  (3071.3) Adult Fat Body  (3220) Adult Salivary Gland  (6434.3) Adult Heart  (3908.35) Adult VirginFemale Spermatheca  (3145.6) Adult InseminatedFemale Spermatheca  (3018.9) Adult Ovary  1120.2 Adult Testis  1274.3 Adult Male Accessory Gland  (2497.5) Adult Carcass  (4512.3) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1330.55 Larval Midgut    2864.3 Larval Hindgut    3015.7 Larval Malpighian Tubules    1766.6 Larval Fat Body    756.6 Larval Salivary Gland    2837.3 Larval Trachea    1989.8 Larval Carcass    2974.625 Adult Head    2610 Adult Eye    3603.125 Adult Brain    2210.8 Adult Thoracic-Abdominal Ganglion    2829.5 Adult Crop    2032.9 Adult Midgut    2514.9 Adult Hindgut    3639.2 Adult Malpighian Tubules    3071.3 Adult Fat Body    3220 Adult Salivary Gland    6434.3 Adult Heart    3908.35 Adult VirginFemale Spermatheca    3145.6 Adult InseminatedFemale Spermatheca    3018.9 Adult Ovary    1120.2 Adult Testis    1274.3 Adult Male Accessory Gland    2497.5 Adult Carcass    4512.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    2610   NA  Eye    3603.125   NA  Brain    2210.8   1330.55  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    2829.5   NA  Crop    2032.9   2864.3  Midgut    2514.9   3015.7  Hindgut    3639.2   1766.6  Malpighian Tubules    3071.3   756.6  Fat Body    3220   2837.3  Salivary Gland    6434.3   NA  Heart    3908.35   1989.8  Trachea    NA   NA  VirginFemale Spermatheca    3145.6   NA  InseminatedFemale Spermatheca    3018.9   NA  Ovary    1120.2   NA  Testis    1274.3   NA  Male Accessory Gland    2497.5   2974.625  Carcass    4512.3 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    173 central nervous system, larvae L3    79 central nervous system, pupae P8    100 head, virgin 1-day female    292 head, virgin 4-day female    173 head, virgin 20-day female    167 head, mated 1-day female    220 head, mated 4-day female    153 head, mated 20-day female    136 head, mated 1-day male    310 head, mated 4-day male    232 head, mated 20-day male    218 salivary gland, larvae L3 wandering    26 salivary gland, white prepupae    22 digestive system, larvae L3 wandering    95 digestive system, 1-day adult    235 digestive system, 4-day adult    148 digestive system, 20-day adult    135 fat body, larvae L3 wandering    43 fat body, white prepupae    37 fat body, pupae P8    135 carcass, larvae L3 wandering    85 carcass, 1-day adult    639 carcass, 4-day adult    297 carcass, 20-day adult    171 ovary, virgin 4-day female    125 ovary, mated 4-day female    97 testis, mated 4-day male    347 accessory gland, mated 4-day male    131 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (173) central nervous system, larvae L3  (79) central nervous system, pupae P8  (100) head, virgin 1-day female  (292) head, virgin 4-day female  (173) head, virgin 20-day female  (167) head, mated 1-day female  (220) head, mated 4-day female  (153) head, mated 20-day female  (136) head, mated 1-day male  (310) head, mated 4-day male  (232) head, mated 20-day male  (218) salivary gland, larvae L3 wandering  26 salivary gland, white prepupae    22 digestive system, larvae L3 wandering  (95) digestive system, 1-day adult  (235) digestive system, 4-day adult  (148) digestive system, 20-day adult  (135) fat body, larvae L3 wandering  (43) fat body, white prepupae  (37) fat body, pupae P8  (135) carcass, larvae L3 wandering  (85) carcass, 1-day adult  (639) carcass, 4-day adult  (297) carcass, 20-day adult  (171) ovary, virgin 4-day female  (125) ovary, mated 4-day female  (97) testis, mated 4-day male  (347) accessory gland, mated 4-day male  (131) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (173) central nervous system, larvae L3    79 central nervous system, pupae P8    100 head, virgin 1-day female  (292) head, virgin 4-day female  (173) head, virgin 20-day female  (167) head, mated 1-day female  (220) head, mated 4-day female  (153) head, mated 20-day female  (136) head, mated 1-day male  (310) head, mated 4-day male  (232) head, mated 20-day male  (218) salivary gland, larvae L3 wandering    26 salivary gland, white prepupae    22 digestive system, larvae L3 wandering    95 digestive system, 1-day adult  (235) digestive system, 4-day adult  (148) digestive system, 20-day adult  (135) fat body, larvae L3 wandering    43 fat body, white prepupae    37 fat body, pupae P8  (135) carcass, larvae L3 wandering    85 carcass, 1-day adult  (639) carcass, 4-day adult  (297) carcass, 20-day adult  (171) ovary, virgin 4-day female  (125) ovary, mated 4-day female    97 testis, mated 4-day male  (347) accessory gland, mated 4-day male  (131) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    173 central nervous system, larvae L3    79 central nervous system, pupae P8    100 head, virgin 1-day female    292 head, virgin 4-day female    173 head, virgin 20-day female    167 head, mated 1-day female    220 head, mated 4-day female    153 head, mated 20-day female    136 head, mated 1-day male    310 head, mated 4-day male    232 head, mated 20-day male    218 salivary gland, larvae L3 wandering    26 salivary gland, white prepupae    22 digestive system, larvae L3 wandering    95 digestive system, 1-day adult    235 digestive system, 4-day adult    148 digestive system, 20-day adult    135 fat body, larvae L3 wandering    43 fat body, white prepupae    37 fat body, pupae P8    135 carcass, larvae L3 wandering    85 carcass, 1-day adult    639 carcass, 4-day adult    297 carcass, 20-day adult    171 ovary, virgin 4-day female    125 ovary, mated 4-day female    97 testis, mated 4-day male    347 accessory gland, mated 4-day male    131 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    173 central nervous system, larvae L3    79 central nervous system, pupae P8    100 head, virgin 1-day female    292 head, virgin 4-day female    173 head, virgin 20-day female    167 head, mated 1-day female    220 head, mated 4-day female    153 head, mated 20-day female    136 head, mated 1-day male    310 head, mated 4-day male    232 head, mated 20-day male    218 salivary gland, larvae L3 wandering    26 salivary gland, white prepupae    22 digestive system, larvae L3 wandering    95 digestive system, 1-day adult    235 digestive system, 4-day adult    148 digestive system, 20-day adult    135 fat body, larvae L3 wandering    43 fat body, white prepupae    37 fat body, pupae P8    135 carcass, larvae L3 wandering    85 carcass, 1-day adult    639 carcass, 4-day adult    297 carcass, 20-day adult    171 ovary, virgin 4-day female    125 ovary, mated 4-day female    97 testis, mated 4-day male    347 accessory gland, mated 4-day male    131 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (173) central nervous system, larvae L3  (79) central nervous system, pupae P8  (100) head, virgin 1-day female  (292) head, virgin 4-day female  (173) head, virgin 20-day female  (167) head, mated 1-day female  (220) head, mated 4-day female  (153) head, mated 20-day female  (136) head, mated 1-day male  (310) head, mated 4-day male  (232) head, mated 20-day male  (218) salivary gland, larvae L3 wandering  26 salivary gland, white prepupae    22 digestive system, larvae L3 wandering  (95) digestive system, 1-day adult  (235) digestive system, 4-day adult  (148) digestive system, 20-day adult  (135) fat body, larvae L3 wandering  (43) fat body, white prepupae  (37) fat body, pupae P8  (135) carcass, larvae L3 wandering  (85) carcass, 1-day adult  (639) carcass, 4-day adult  (297) carcass, 20-day adult  (171) ovary, virgin 4-day female  (125) ovary, mated 4-day female  (97) testis, mated 4-day male  (347) accessory gland, mated 4-day male  (131) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (173) central nervous system, larvae L3    79 central nervous system, pupae P8    100 head, virgin 1-day female  (292) head, virgin 4-day female  (173) head, virgin 20-day female  (167) head, mated 1-day female  (220) head, mated 4-day female  (153) head, mated 20-day female  136 head, mated 1-day male  (310) head, mated 4-day male  (232) head, mated 20-day male  (218) salivary gland, larvae L3 wandering    26 salivary gland, white prepupae    22 digestive system, larvae L3 wandering    95 digestive system, 1-day adult  (235) digestive system, 4-day adult  (148) digestive system, 20-day adult  135 fat body, larvae L3 wandering    43 fat body, white prepupae    37 fat body, pupae P8  135 carcass, larvae L3 wandering    85 carcass, 1-day adult  (639) carcass, 4-day adult  (297) carcass, 20-day adult  (171) ovary, virgin 4-day female  125 ovary, mated 4-day female    97 testis, mated 4-day male  (347) accessory gland, mated 4-day male  131 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    173 central nervous system, larvae L3    79 central nervous system, pupae P8    100 head, virgin 1-day female    292 head, virgin 4-day female    173 head, virgin 20-day female    167 head, mated 1-day female    220 head, mated 4-day female    153 head, mated 20-day female    136 head, mated 1-day male    310 head, mated 4-day male    232 head, mated 20-day male    218 salivary gland, larvae L3 wandering    26 salivary gland, white prepupae    22 digestive system, larvae L3 wandering    95 digestive system, 1-day adult    235 digestive system, 4-day adult    148 digestive system, 20-day adult    135 fat body, larvae L3 wandering    43 fat body, white prepupae    37 fat body, pupae P8    135 carcass, larvae L3 wandering    85 carcass, 1-day adult    639 carcass, 4-day adult    297 carcass, 20-day adult    171 ovary, virgin 4-day female    125 ovary, mated 4-day female    97 testis, mated 4-day male    347 accessory gland, mated 4-day male    131 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of very high expression. Peak expression observed during late pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    279 embryo 02-04hr    351 embryo 04-06hr    258 embryo 06-08hr    215 embryo 08-10hr    205 embryo 10-12hr    364 embryo 12-14hr    222 embryo 14-16hr    407 embryo 16-18hr    448 embryo 18-20hr    583 embryo 20-22hr    717 embryo 22-24hr    601 larva L1    1000 larva L2    889 larva L3 12hr old    852 larva L3 puffstage 1-2    475 larva L3 puffstage 3-6    272 larva L3 puffstage 7-9    199 white prepupae new    180 white prepupae 12hr    182 white prepupae 24hr    188 pupae 2d postWPP    367 pupae 3d postWPP    923 pupae 4d postWPP    1716 adult male 01day    1352 adult male 05day    1089 adult male 30day    607 adult female 01day    1404 adult female 05day    466 adult female 30day    352 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (279) embryo 02-04hr  (351) embryo 04-06hr  (258) embryo 06-08hr  (215) embryo 08-10hr  (205) embryo 10-12hr  (364) embryo 12-14hr  (222) embryo 14-16hr  (407) embryo 16-18hr  (448) embryo 18-20hr  (583) embryo 20-22hr  (717) embryo 22-24hr  (601) larva L1  (1000) larva L2  (889) larva L3 12hr old  (852) larva L3 puffstage 1-2  (475) larva L3 puffstage 3-6  (272) larva L3 puffstage 7-9  (199) white prepupae new  (180) white prepupae 12hr  (182) white prepupae 24hr  (188) pupae 2d postWPP  (367) pupae 3d postWPP  (923) pupae 4d postWPP  (1716) adult male 01day  (1352) adult male 05day  (1089) adult male 30day  (607) adult female 01day  (1404) adult female 05day  (466) adult female 30day  (352) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (279) embryo 02-04hr  (351) embryo 04-06hr  (258) embryo 06-08hr  (215) embryo 08-10hr  (205) embryo 10-12hr  (364) embryo 12-14hr  (222) embryo 14-16hr  (407) embryo 16-18hr  (448) embryo 18-20hr  (583) embryo 20-22hr  (717) embryo 22-24hr  (601) larva L1  (1000) larva L2  (889) larva L3 12hr old  (852) larva L3 puffstage 1-2  (475) larva L3 puffstage 3-6  (272) larva L3 puffstage 7-9  (199) white prepupae new  (180) white prepupae 12hr  (182) white prepupae 24hr  (188) pupae 2d postWPP  (367) pupae 3d postWPP  (923) pupae 4d postWPP  (1716) adult male 01day  (1352) adult male 05day  (1089) adult male 30day  (607) adult female 01day  (1404) adult female 05day  (466) adult female 30day  (352) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    279 embryo 02-04hr    351 embryo 04-06hr    258 embryo 06-08hr    215 embryo 08-10hr    205 embryo 10-12hr    364 embryo 12-14hr    222 embryo 14-16hr    407 embryo 16-18hr    448 embryo 18-20hr    583 embryo 20-22hr    717 embryo 22-24hr    601 larva L1    1000 larva L2    889 larva L3 12hr old    852 larva L3 puffstage 1-2    475 larva L3 puffstage 3-6    272 larva L3 puffstage 7-9    199 white prepupae new    180 white prepupae 12hr    182 white prepupae 24hr    188 pupae 2d postWPP    367 pupae 3d postWPP    923 pupae 4d postWPP    1716 adult male 01day    1352 adult male 05day    1089 adult male 30day    607 adult female 01day    1404 adult female 05day    466 adult female 30day    352 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    279 embryo 02-04hr    351 embryo 04-06hr    258 embryo 06-08hr    215 embryo 08-10hr    205 embryo 10-12hr    364 embryo 12-14hr    222 embryo 14-16hr    407 embryo 16-18hr    448 embryo 18-20hr    583 embryo 20-22hr    717 embryo 22-24hr    601 larva L1    1000 larva L2    889 larva L3 12hr old    852 larva L3 puffstage 1-2    475 larva L3 puffstage 3-6    272 larva L3 puffstage 7-9    199 white prepupae new    180 white prepupae 12hr    182 white prepupae 24hr    188 pupae 2d postWPP    367 pupae 3d postWPP    923 pupae 4d postWPP    1716 adult male 01day    1352 adult male 05day    1089 adult male 30day    607 adult female 01day    1404 adult female 05day    466 adult female 30day    352 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (279) embryo 02-04hr  (351) embryo 04-06hr  (258) embryo 06-08hr  (215) embryo 08-10hr  (205) embryo 10-12hr  (364) embryo 12-14hr  (222) embryo 14-16hr  (407) embryo 16-18hr  (448) embryo 18-20hr  (583) embryo 20-22hr  (717) embryo 22-24hr  (601) larva L1  (1000) larva L2  (889) larva L3 12hr old  (852) larva L3 puffstage 1-2  (475) larva L3 puffstage 3-6  (272) larva L3 puffstage 7-9  (199) white prepupae new  (180) white prepupae 12hr  (182) white prepupae 24hr  (188) pupae 2d postWPP  (367) pupae 3d postWPP  (923) pupae 4d postWPP  (1716) adult male 01day  (1352) adult male 05day  (1089) adult male 30day  (607) adult female 01day  (1404) adult female 05day  (466) adult female 30day  (352) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (279) embryo 02-04hr  (351) embryo 04-06hr  (258) embryo 06-08hr  (215) embryo 08-10hr  (205) embryo 10-12hr  (364) embryo 12-14hr  (222) embryo 14-16hr  (407) embryo 16-18hr  (448) embryo 18-20hr  (583) embryo 20-22hr  (717) embryo 22-24hr  (601) larva L1  (1000) larva L2  (889) larva L3 12hr old  (852) larva L3 puffstage 1-2  (475) larva L3 puffstage 3-6  (272) larva L3 puffstage 7-9  (199) white prepupae new  (180) white prepupae 12hr  (182) white prepupae 24hr  (188) pupae 2d postWPP  (367) pupae 3d postWPP  (923) pupae 4d postWPP  (1716) adult male 01day  (1352) adult male 05day  (1089) adult male 30day  (607) adult female 01day  (1404) adult female 05day  (466) adult female 30day  (352) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    279 embryo 02-04hr    351 embryo 04-06hr    258 embryo 06-08hr    215 embryo 08-10hr    205 embryo 10-12hr    364 embryo 12-14hr    222 embryo 14-16hr    407 embryo 16-18hr    448 embryo 18-20hr    583 embryo 20-22hr    717 embryo 22-24hr    601 larva L1    1000 larva L2    889 larva L3 12hr old    852 larva L3 puffstage 1-2    475 larva L3 puffstage 3-6    272 larva L3 puffstage 7-9    199 white prepupae new    180 white prepupae 12hr    182 white prepupae 24hr    188 pupae 2d postWPP    367 pupae 3d postWPP    923 pupae 4d postWPP    1716 adult male 01day    1352 adult male 05day    1089 adult male 30day    607 adult female 01day    1404 adult female 05day    466 adult female 30day    352 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    214 Schneider line 2 Sg4    348 embryonic 1182-4H    134 embryonic GM2    71 embryonic Kc167    143 embryonic S1    177 embryonic S3    253 leg disc CME L1    182 wing disc CME-W2    292 wing disc ML-DmD8    175 wing disc ML-DmD9    195 wing disc ML-DmD16-c3    141 wing disc ML-DmD21    430 wing disc ML-DmD32    174 haltere disc ML-DmD17-c3    187 eye-antennal disc ML-DmD11    410 antennal disc ML-DmD20-c5    276 mixed discs ML-DmD4-c1    192 CNS ML-DmBG1-c1    195 CNS ML-DmBG2-c2    205 tumorous blood cells mbn2    154 ovary fGS/OSS    97 ovary OSC    81 ovary OSS    39 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (214) Schneider line 2 Sg4  (348) embryonic 1182-4H  (134) embryonic GM2  (71) embryonic Kc167  (143) embryonic S1  (177) embryonic S3  (253) leg disc CME L1  (182) wing disc CME-W2  (292) wing disc ML-DmD8  (175) wing disc ML-DmD9  (195) wing disc ML-DmD16-c3  (141) wing disc ML-DmD21  (430) wing disc ML-DmD32  (174) haltere disc ML-DmD17-c3  (187) eye-antennal disc ML-DmD11  (410) antennal disc ML-DmD20-c5  (276) mixed discs ML-DmD4-c1  (192) CNS ML-DmBG1-c1  (195) CNS ML-DmBG2-c2  (205) tumorous blood cells mbn2  (154) ovary fGS/OSS  (97) ovary OSC  (81) ovary OSS  (39) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (214) Schneider line 2 Sg4  (348) embryonic 1182-4H  (134) embryonic GM2    71 embryonic Kc167  (143) embryonic S1  (177) embryonic S3  (253) leg disc CME L1  (182) wing disc CME-W2  (292) wing disc ML-DmD8  (175) wing disc ML-DmD9  (195) wing disc ML-DmD16-c3  (141) wing disc ML-DmD21  (430) wing disc ML-DmD32  (174) haltere disc ML-DmD17-c3  (187) eye-antennal disc ML-DmD11  (410) antennal disc ML-DmD20-c5  (276) mixed discs ML-DmD4-c1  (192) CNS ML-DmBG1-c1  (195) CNS ML-DmBG2-c2  (205) tumorous blood cells mbn2  (154) ovary fGS/OSS    97 ovary OSC    81 ovary OSS    39 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    214 Schneider line 2 Sg4    348 embryonic 1182-4H    134 embryonic GM2    71 embryonic Kc167    143 embryonic S1    177 embryonic S3    253 leg disc CME L1    182 wing disc CME-W2    292 wing disc ML-DmD8    175 wing disc ML-DmD9    195 wing disc ML-DmD16-c3    141 wing disc ML-DmD21    430 wing disc ML-DmD32    174 haltere disc ML-DmD17-c3    187 eye-antennal disc ML-DmD11    410 antennal disc ML-DmD20-c5    276 mixed discs ML-DmD4-c1    192 CNS ML-DmBG1-c1    195 CNS ML-DmBG2-c2    205 tumorous blood cells mbn2    154 ovary fGS/OSS    97 ovary OSC    81 ovary OSS    39 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    214 Schneider line 2 Sg4    348 embryonic 1182-4H    134 embryonic GM2    71 embryonic Kc167    143 embryonic S1    177 embryonic S3    253 leg disc CME L1    182 wing disc CME-W2    292 wing disc ML-DmD8    175 wing disc ML-DmD9    195 wing disc ML-DmD16-c3    141 wing disc ML-DmD21    430 wing disc ML-DmD32    174 haltere disc ML-DmD17-c3    187 eye-antennal disc ML-DmD11    410 antennal disc ML-DmD20-c5    276 mixed discs ML-DmD4-c1    192 CNS ML-DmBG1-c1    195 CNS ML-DmBG2-c2    205 tumorous blood cells mbn2    154 ovary fGS/OSS    97 ovary OSC    81 ovary OSS    39 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (214) Schneider line 2 Sg4  (348) embryonic 1182-4H  (134) embryonic GM2  (71) embryonic Kc167  (143) embryonic S1  (177) embryonic S3  (253) leg disc CME L1  (182) wing disc CME-W2  (292) wing disc ML-DmD8  (175) wing disc ML-DmD9  (195) wing disc ML-DmD16-c3  (141) wing disc ML-DmD21  (430) wing disc ML-DmD32  (174) haltere disc ML-DmD17-c3  (187) eye-antennal disc ML-DmD11  (410) antennal disc ML-DmD20-c5  (276) mixed discs ML-DmD4-c1  (192) CNS ML-DmBG1-c1  (195) CNS ML-DmBG2-c2  (205) tumorous blood cells mbn2  (154) ovary fGS/OSS  (97) ovary OSC  (81) ovary OSS  (39) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (214) Schneider line 2 Sg4  (348) embryonic 1182-4H  134 embryonic GM2    71 embryonic Kc167  143 embryonic S1  (177) embryonic S3  (253) leg disc CME L1  (182) wing disc CME-W2  (292) wing disc ML-DmD8  (175) wing disc ML-DmD9  (195) wing disc ML-DmD16-c3  141 wing disc ML-DmD21  (430) wing disc ML-DmD32  (174) haltere disc ML-DmD17-c3  (187) eye-antennal disc ML-DmD11  (410) antennal disc ML-DmD20-c5  (276) mixed discs ML-DmD4-c1  (192) CNS ML-DmBG1-c1  (195) CNS ML-DmBG2-c2  (205) tumorous blood cells mbn2  (154) ovary fGS/OSS    97 ovary OSC    81 ovary OSS    39 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    214 Schneider line 2 Sg4    348 embryonic 1182-4H    134 embryonic GM2    71 embryonic Kc167    143 embryonic S1    177 embryonic S3    253 leg disc CME L1    182 wing disc CME-W2    292 wing disc ML-DmD8    175 wing disc ML-DmD9    195 wing disc ML-DmD16-c3    141 wing disc ML-DmD21    430 wing disc ML-DmD32    174 haltere disc ML-DmD17-c3    187 eye-antennal disc ML-DmD11    410 antennal disc ML-DmD20-c5    276 mixed discs ML-DmD4-c1    192 CNS ML-DmBG1-c1    195 CNS ML-DmBG2-c2    205 tumorous blood cells mbn2    154 ovary fGS/OSS    97 ovary OSC    81 ovary OSS    39 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    109 cold shock, 4-day adult    69 heat shock, 4-day adult    314 Cadmium 50 mM 6 hrs, larvae L3    433 Cadmium 50 mM 12 hrs, larvae L3    271 Cadmium 50 mM 48 hrs, 4-day adult    286 Cadmium 100 mM 48 hrs, 4-day adult    156 Copper 0.5 mM 12 hrs, larvae L3    167 Copper 15 mM 48 hrs, 4-day adult    99 Zinc 5 mM 12 hrs, larvae L3    122 Zinc 4.5 mM 48 hrs, 4-day adult    126 Ethanol 2.5% 3 hrs, larvae L3    276 Ethanol 5% 3 hrs, larvae L3    487 Ethanol 10% 3 hrs, larvae L3    431 Caffeine 1.5 mg/ml 4 hrs, larvae L3    365 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    137 Caffeine 25 mg/ml 48 hrs, 4-day adult    87 Paraquat 5 mM 48 hrs, 4-day adult    283 Paraquat 10 mM 48 hrs, 4-day adult    287 Rotenone 2 μg 12 hrs, larvae L3    436 Rotenone 8 μg 12 hrs, larvae L3    501 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (109) cold shock, 4-day adult  (69) heat shock, 4-day adult  (314) Cadmium 50 mM 6 hrs, larvae L3  (433) Cadmium 50 mM 12 hrs, larvae L3  (271) Cadmium 50 mM 48 hrs, 4-day adult  (286) Cadmium 100 mM 48 hrs, 4-day adult  (156) Copper 0.5 mM 12 hrs, larvae L3  (167) Copper 15 mM 48 hrs, 4-day adult  (99) Zinc 5 mM 12 hrs, larvae L3  (122) Zinc 4.5 mM 48 hrs, 4-day adult  (126) Ethanol 2.5% 3 hrs, larvae L3  (276) Ethanol 5% 3 hrs, larvae L3  (487) Ethanol 10% 3 hrs, larvae L3  (431) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (365) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (137) Caffeine 25 mg/ml 48 hrs, 4-day adult  (87) Paraquat 5 mM 48 hrs, 4-day adult  (283) Paraquat 10 mM 48 hrs, 4-day adult  (287) Rotenone 2 μg 12 hrs, larvae L3  (436) Rotenone 8 μg 12 hrs, larvae L3  (501) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (109) cold shock, 4-day adult    69 heat shock, 4-day adult  (314) Cadmium 50 mM 6 hrs, larvae L3  (433) Cadmium 50 mM 12 hrs, larvae L3  (271) Cadmium 50 mM 48 hrs, 4-day adult  (286) Cadmium 100 mM 48 hrs, 4-day adult  (156) Copper 0.5 mM 12 hrs, larvae L3  (167) Copper 15 mM 48 hrs, 4-day adult    99 Zinc 5 mM 12 hrs, larvae L3  (122) Zinc 4.5 mM 48 hrs, 4-day adult  (126) Ethanol 2.5% 3 hrs, larvae L3  (276) Ethanol 5% 3 hrs, larvae L3  (487) Ethanol 10% 3 hrs, larvae L3  (431) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (365) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (137) Caffeine 25 mg/ml 48 hrs, 4-day adult    87 Paraquat 5 mM 48 hrs, 4-day adult  (283) Paraquat 10 mM 48 hrs, 4-day adult  (287) Rotenone 2 μg 12 hrs, larvae L3  (436) Rotenone 8 μg 12 hrs, larvae L3  (501) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    109 cold shock, 4-day adult    69 heat shock, 4-day adult    314 Cadmium 50 mM 6 hrs, larvae L3    433 Cadmium 50 mM 12 hrs, larvae L3    271 Cadmium 50 mM 48 hrs, 4-day adult    286 Cadmium 100 mM 48 hrs, 4-day adult    156 Copper 0.5 mM 12 hrs, larvae L3    167 Copper 15 mM 48 hrs, 4-day adult    99 Zinc 5 mM 12 hrs, larvae L3    122 Zinc 4.5 mM 48 hrs, 4-day adult    126 Ethanol 2.5% 3 hrs, larvae L3    276 Ethanol 5% 3 hrs, larvae L3    487 Ethanol 10% 3 hrs, larvae L3    431 Caffeine 1.5 mg/ml 4 hrs, larvae L3    365 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    137 Caffeine 25 mg/ml 48 hrs, 4-day adult    87 Paraquat 5 mM 48 hrs, 4-day adult    283 Paraquat 10 mM 48 hrs, 4-day adult    287 Rotenone 2 μg 12 hrs, larvae L3    436 Rotenone 8 μg 12 hrs, larvae L3    501 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    109 cold shock, 4-day adult    69 heat shock, 4-day adult    314 Cadmium 50 mM 6 hrs, larvae L3    433 Cadmium 50 mM 12 hrs, larvae L3    271 Cadmium 50 mM 48 hrs, 4-day adult    286 Cadmium 100 mM 48 hrs, 4-day adult    156 Copper 0.5 mM 12 hrs, larvae L3    167 Copper 15 mM 48 hrs, 4-day adult    99 Zinc 5 mM 12 hrs, larvae L3    122 Zinc 4.5 mM 48 hrs, 4-day adult    126 Ethanol 2.5% 3 hrs, larvae L3    276 Ethanol 5% 3 hrs, larvae L3    487 Ethanol 10% 3 hrs, larvae L3    431 Caffeine 1.5 mg/ml 4 hrs, larvae L3    365 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    137 Caffeine 25 mg/ml 48 hrs, 4-day adult    87 Paraquat 5 mM 48 hrs, 4-day adult    283 Paraquat 10 mM 48 hrs, 4-day adult    287 Rotenone 2 μg 12 hrs, larvae L3    436 Rotenone 8 μg 12 hrs, larvae L3    501 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (109) cold shock, 4-day adult  (69) heat shock, 4-day adult  (314) Cadmium 50 mM 6 hrs, larvae L3  (433) Cadmium 50 mM 12 hrs, larvae L3  (271) Cadmium 50 mM 48 hrs, 4-day adult  (286) Cadmium 100 mM 48 hrs, 4-day adult  (156) Copper 0.5 mM 12 hrs, larvae L3  (167) Copper 15 mM 48 hrs, 4-day adult  (99) Zinc 5 mM 12 hrs, larvae L3  (122) Zinc 4.5 mM 48 hrs, 4-day adult  (126) Ethanol 2.5% 3 hrs, larvae L3  (276) Ethanol 5% 3 hrs, larvae L3  (487) Ethanol 10% 3 hrs, larvae L3  (431) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (365) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (137) Caffeine 25 mg/ml 48 hrs, 4-day adult  (87) Paraquat 5 mM 48 hrs, 4-day adult  (283) Paraquat 10 mM 48 hrs, 4-day adult  (287) Rotenone 2 μg 12 hrs, larvae L3  (436) Rotenone 8 μg 12 hrs, larvae L3  (501) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  109 cold shock, 4-day adult    69 heat shock, 4-day adult  (314) Cadmium 50 mM 6 hrs, larvae L3  (433) Cadmium 50 mM 12 hrs, larvae L3  (271) Cadmium 50 mM 48 hrs, 4-day adult  (286) Cadmium 100 mM 48 hrs, 4-day adult  (156) Copper 0.5 mM 12 hrs, larvae L3  (167) Copper 15 mM 48 hrs, 4-day adult    99 Zinc 5 mM 12 hrs, larvae L3  122 Zinc 4.5 mM 48 hrs, 4-day adult  126 Ethanol 2.5% 3 hrs, larvae L3  (276) Ethanol 5% 3 hrs, larvae L3  (487) Ethanol 10% 3 hrs, larvae L3  (431) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (365) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  137 Caffeine 25 mg/ml 48 hrs, 4-day adult    87 Paraquat 5 mM 48 hrs, 4-day adult  (283) Paraquat 10 mM 48 hrs, 4-day adult  (287) Rotenone 2 μg 12 hrs, larvae L3  (436) Rotenone 8 μg 12 hrs, larvae L3  (501) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    109 cold shock, 4-day adult    69 heat shock, 4-day adult    314 Cadmium 50 mM 6 hrs, larvae L3    433 Cadmium 50 mM 12 hrs, larvae L3    271 Cadmium 50 mM 48 hrs, 4-day adult    286 Cadmium 100 mM 48 hrs, 4-day adult    156 Copper 0.5 mM 12 hrs, larvae L3    167 Copper 15 mM 48 hrs, 4-day adult    99 Zinc 5 mM 12 hrs, larvae L3    122 Zinc 4.5 mM 48 hrs, 4-day adult    126 Ethanol 2.5% 3 hrs, larvae L3    276 Ethanol 5% 3 hrs, larvae L3    487 Ethanol 10% 3 hrs, larvae L3    431 Caffeine 1.5 mg/ml 4 hrs, larvae L3    365 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    137 Caffeine 25 mg/ml 48 hrs, 4-day adult    87 Paraquat 5 mM 48 hrs, 4-day adult    283 Paraquat 10 mM 48 hrs, 4-day adult    287 Rotenone 2 μg 12 hrs, larvae L3    436 Rotenone 8 μg 12 hrs, larvae L3    501 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_15 mE1_20_mRNA_expression_cluster_01
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0019644 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8189-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 ATPsyn-bGD6129 viable ATPsyn-bEY03793 Sterility Allele fertile ATPsyn-bEY03793 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 ATPsyn-bGD6129 Phenotype manifest in Allele mesothoracic tergum, with Scer\GAL4pnr-MD237 ATPsyn-bGD6129 trichogen cell, with Scer\GAL4pnr-MD237 ATPsyn-bGD6129
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of ATPsyn-b Class Mutagen Stocks Known lesion ATPsyn-bEY03793 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of ATPsyn-b Class Mutagen Stocks Known lesion ATPsyn-bGD6129 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes ATPsyn-bJF02899 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ATPsyn-bKK108066 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ATPsyn-bNIG.8189R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD6129} NA P{KK108066} NA P{NIG.8189R} NA P{TRiP.JF02899} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}ATPsyn-bEY03793 NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
phagocytosis, engulfment inferred from mutant phenotype (Stroschein-Stevenson et al., 2006)
Cellular Component
CV term Evidence References
lipid particle inferred from direct assay (Beller et al., 2006)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
hydrogen-exporting ATPase activity, phosphorylative mechanism inferred from sequence or structural similarity with UniProtKB:P13619 (FlyBase, 1992-) inferred from sequence or structural similarity with UniProtKB:P24539 (Sardiello et al., 2003.6.11) non-traceable author statement (Caggese, 1996.10.21, Swiss-Prot Project Members, 1999.12.15) proton-transporting ATP synthase activity, rotational mechanism inferred from biological aspect of ancestor with PANTHER:PTN000296496 (assigned by RefGenome) (Gaudet et al., 2010)
Biological Process
CV term Evidence References
ATP synthesis coupled proton transport inferred from biological aspect of ancestor with PANTHER:PTN000296496 (assigned by RefGenome) (Gaudet et al., 2010) proton transport inferred from sequence or structural similarity with UniProtKB:P24539 (Sardiello et al., 2003.6.11) non-traceable author statement (Swiss-Prot Project Members, 1999.12.15)
Cellular Component
CV term Evidence References
mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) inferred from biological aspect of ancestor with PANTHER:PTN000296496 (assigned by RefGenome) (Gaudet et al., 2010) inferred from sequence or structural similarity with UniProtKB:P24539 (Sardiello et al., 2003.6.11)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
ATPsyn-b - ATPsyn-Cf6 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) ATPsyn-b - ATPsyn-d anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) ATPsyn-b - ATPsyn-γ experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) ATPsyn-b - Acon experimental knowledge based (Guruharsha et al., 2011) ATPsyn-b - Arpc1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ATPsyn-b - Arpc2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ATPsyn-b - Bap55 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ATPsyn-b - CG10306 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ATPsyn-b - CG10581 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ATPsyn-b - CG11107 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ATPsyn-b - CG11266 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ATPsyn-b - CG12170 experimental knowledge based (Guruharsha et al., 2011) ATPsyn-b - CG15220 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ATPsyn-b - CG31522 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) ATPsyn-b - CG3321 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) ATPsyn-b - CG34163 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ATPsyn-b - CG3689 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ATPsyn-b - CG3817 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ATPsyn-b - CG3862 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ATPsyn-b - CG4611 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ATPsyn-b - CG4692 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) ATPsyn-b - CG4797 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) ATPsyn-b - CG6330 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ATPsyn-b - CG8728 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ATPsyn-b - CG9769 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ATPsyn-b - Dgp-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ATPsyn-b - Dh44-R2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ATPsyn-b - Eb1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ATPsyn-b - Gdh experimental knowledge based (Guruharsha et al., 2011) ATPsyn-b - Gpdh experimental knowledge based (Guruharsha et al., 2011) ATPsyn-b - His3.3B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ATPsyn-b - Imp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ATPsyn-b - LRP1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ATPsyn-b - M6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ATPsyn-b - Mf experimental knowledge based (Guruharsha et al., 2011) ATPsyn-b - Mlc1 experimental knowledge based (Guruharsha et al., 2011) ATPsyn-b - Mlc2 experimental knowledge based (Guruharsha et al., 2011) ATPsyn-b - Ns1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ATPsyn-b - Oscp experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) ATPsyn-b - Ote anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ATPsyn-b - Pgam5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ATPsyn-b - Pis anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ATPsyn-b - RPA2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ATPsyn-b - RpL35A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ATPsyn-b - Saf-B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ATPsyn-b - Scp1 experimental knowledge based (Guruharsha et al., 2011) ATPsyn-b - Tm2 experimental knowledge based (Guruharsha et al., 2011) ATPsyn-b - Tsp29Fb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ATPsyn-b - blw experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) ATPsyn-b - flw anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ATPsyn-b - isoQC anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ATPsyn-b - jagn experimental knowledge based (Guruharsha et al., 2011) ATPsyn-b - l(1)G0230 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) ATPsyn-b - l(2)06225 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) ATPsyn-b - mRpL52 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ATPsyn-b - mRpS24 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ATPsyn-b - mRpS33 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ATPsyn-b - mTerf3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ATPsyn-b - nonA-l anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ATPsyn-b - nop5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ATPsyn-b - porin experimental knowledge based (Guruharsha et al., 2011) ATPsyn-b - sun anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) ATPsyn-b - up experimental knowledge based (Guruharsha et al., 2011) ATPsyn-b - wupA experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions ATPsyn-b allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64531 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0019644 DroID - A comprehensive database of gene and protein interactions. • FBgn0019644 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39143
Orthologs
OrthoDB Orthologs (49) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6RXZKH Dipteran inclusive ortholog search EOG6FJ8JX Insect inclusive ortholog search EOG6G79VH Arthropod inclusive ortholog search EOG67M0F1 Metazoa inclusive ortholog search EOG6GFG87
Orthologs in Drosophila Species (EOG6RXZKH)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\ATPsyn-b     Drosophila simulans   Dsim\GD14214 Y   Drosophila sechellia   Dsec\GM25183 Y   Drosophila erecta   Dere\GG15409 Y   Drosophila yakuba   Dyak\GE20875 Y   Drosophila ananassae   Dana\GF24674 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA20881 Y   Drosophila persimilis   Dper\GL16292 Y   Drosophila willistoni   Dwil\GK10957 Y   Drosophila virilis   Dvir\GJ12126 Y   Drosophila mojavensis   Dmoj\GI13031 Y   Drosophila grimshawi   Dgri\GH15429 Y
Orthologs in non-Drosophila Dipterans (EOG6FJ8JX)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL005610   Anopheles gambiae Malaria mosquito  Agam\AGAP001138   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ006067
Orthologs in non-Dipteran Insects (EOG6G79VH)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\Ame.6533   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG002147   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH25653   Atta cephalotes Leafcutter ant  Acep\ACEP21758   Camponotus floridanus Florida carpenter ant  Cflo\CFLO17225   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL18140   Linepithema humile Argentine ant  Lhum\LH23118   Pogonomyrmex barbatus Red harvester ant  Pbar\PB13534   Solenopsis invicta Red fire ant  Sinv\SINV14012   Acyrthosiphon pisum Pea aphid  Apim\ACYPI000875   Acyrthosiphon pisum Pea aphid  Apim\ACYPI004922   Acyrthosiphon pisum Pea aphid  Apim\ACYPI39954   Acyrthosiphon pisum Pea aphid  Apim\ACYPI084199   Acyrthosiphon pisum Pea aphid  Apim\ACYPI000258   Acyrthosiphon pisum Pea aphid  Apim\ACYPI005304   Acyrthosiphon pisum Pea aphid  Apim\ACYPI009780   Bombyx mori Silkmoth  Bmor\BGIBMGA008670   Pediculus humanus Human body louse  Phum\PHUM079790   Tribolium castaneum Red flour beetle  Tcas\TC009556
Orthologs in non-Insect Arthropods (EOG67M0F1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_252899   Daphnia pulex Water flea  Dpux\rbcL   Daphnia pulex Water flea  Dpux\JGI_V11_231350   Daphnia pulex Water flea  Dpux\JGI_V11_259866   Daphnia pulex Water flea  Dpux\ATPB   Ixodes scapularis Deer tick  Isca\ISCW012060
Orthologs in non-Arthropod Metazoa (EOG6GFG87)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\asb-2   Caenorhabditis elegans Nematode  Cele\asb-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000022gn   Danio rerio Zebrafish  Drer\atp5f1   Xenopus tropicalis Western clawed frog  Xtro\atp5f1   Gallus gallus Domestic chicken  Ggal\ATP5F1   Mus musculus House mouse  Mmus\Atp5f1   Rattus norvegicus Norway rat  Rnor\Atp5f1   Homo sapiens Human  Hsap\ENSG00000116459
Human Orthologs (1)
Gene OMIM HGNC Hsap\ENSG00000116459
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD14214 Drosophila sechellia Dsec\GM25183 Drosophila erecta Dere\GG15409 Drosophila yakuba Dyak\GE20875 Drosophila ananassae Dana\GF24674 Drosophila pseudoobscura pseudoobscura Dpse\GA20881 Drosophila persimilis Dper\GL16292 Drosophila willistoni Dwil\GK10957 Drosophila virilis Dvir\GJ12126 Drosophila mojavensis Dmoj\GI13031 Drosophila grimshawi Dgri\GH15429
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	28062 y1 v1; P{TRiP.JF02899}attP2 16575 y1 w67c23; P{EPgy2}ATPsyn-bEY03793
VDRC	v106758 P{KK108066}VIE-260B v14210 w1118; P{GD6129}v14210 v14211 w1118; P{GD6129}v14211
Genomic Clones ( 2 )
	BACR02B01 BACR07E07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 235 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM13038 RE36486
Other clones	DPiM_RE36486
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT05556 AT06129 AT06483 AT08796 AT09529 AT16957 AT23762 AT24681 AT30538 AT31688 GH01603 GH03734 GH04554 GH10707 GH11132 GH12132 GH12506 GH14222 GH20881 GH24780 GH25049 GH26377 GM06582 GM12325 GM15440 GM18770 GM29007 GM30443 GM30924 GM31343 GM32303 HL03452 HL07957 HL07959 LD04527 LD41768 LP02006 LP02649 LP06643 LP06667 LP06929 LP12291 LP23651 RE02446 RE02937 RE10518 RE14133 RE15158 RE26040 RE26513 RE27526 RE27551 RE27967 RE29773 RE31595 RE37495 RE49352 RE51252 RE55160 RE60192 RH02005 RH03010 RH03035 RH04092 RH07535 RH09627 RH10485 RH13636 RH13892 RH14540 RH14584 RH17161 RH17263 RH17371 RH17555 RH17642 RH20677 RH21025 RH21892 RH21960 RH23293 RH23436 RH23842 RH26454 RH30016 RH33135 RH34514 RH36412 RH38787 RH40339 RH41848 RH42002 RH44036 RH44459 RH46347 RH49768 RH50265 RH50306 RH50778 RH51438 RH53769 RH54741 RH55342 RH56457 RH56970 RH57993 RH59057 RH61492 RH61509 RH62542 RH62804 RH63175 RH68554 RH68609 RH69227 RH70219 RH71813 RH72908 SD10117 SD11852 SD19525
Other clones	7589 8837 61772 75134 99159 149563 172449 569555 AT10378 bs06h07 bs57b11 bs75d11 CK01.23C.G3 CK01.33D.H3 CK01.112A.C2 CK01.112A.D2 CK01.118C.H6 Dmel_dig_007795_0595_1742 Dmel_dig_016184_0605_0708 Dmel_dig_016814_0652_3241 Dmel_neb_002226_0135_0490 Dmel_neb_011203_0938_1818 Dmel_neb_011664_0579_1274 Dmel_neb_012230_0102_3301 Dmel_neb_013593_0441_3166 Dmel_neb_014761_0146_0910 Dmel_neb_015725_0377_2848 EC31716 EK021426 EK030023 EK089863 EK107516 EK125648 EK206037 EN15132 FGH123A07 FGM236G01 FGM308E11 GH11972 GM02453 IP02304 IP07617 RE49646 RH01488 RH03406 RH03854 RH23794 RH29118 RH29218 RH33769 RH65611 RH70060 RP003016659 RP003036613 RP003066796 RP003074439 RP003110630 RP003113979 RP003115152 RP003122084 RP003129282 RP003142869 RP003158654 RP003170112 RP003192360 RP003193415 RP003202756 RP003212906 RP003220410 RP003230967 RP003238590 RP003247276 RP003250575 RP003258977 RP003273475 RP003282026 RP003286735 RP003288173 RP003292106 RP003320664 RP003320824 RP003328808 RP003348252 RP003360585 RP003385534 RP003407689 RP003443866 RP003483394 RP003488773 RP003493966 RP003499804 RP003504312 RP003522031 RP003531555 RP003534042 RP003541562 RP003550186 RP003579918 RP003583684 RP003593689 RP003594136 RP003602975 RP003605708 RP003624662 RP003639562 RP003643522 RP003647388 RP003656568 RP003656926 RP003667688 RP003673855
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0019644 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39143
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: ATPsyn-b CG8189 (Zhang, 1999.11)
Source for database merge of
Additional comments
Other Comments
	S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells. (Stroschein-Stevenson et al., 2006)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079287 RefSeq (Proteins) • NP_524011 DDBJ / EMBL / GenBank • AA801802 AAF50212 AAN11955 AAO45234 AI405129 AI944911 AW941364 BI239879 BT004878 CAA70164 CL527721 Y08967 Entrez Gene - A searchable database of RefSeq genes. • 39143 UniProtKB/Swiss-Prot • Q94516
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • ATPase, F0 complex, B chain/subunit B/MI25 (IPR008688) ATPase, F0 complex, B chain/subunit B (IPR013837) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME08189
Linkouts
	BioGRID - A database of protein and genetic interactions • 64531 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0019644 DroID - A comprehensive database of gene and protein interactions. • FBgn0019644 DRSC - Results from RNAi screens. • FBgn0019644 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0019644 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8189-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0019644 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39143 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39143 modMine - Data generated by the modENCODE project. • FBgn0019644
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	ATPsyn-b (Beller et al., 2006, Stroschein-Stevenson et al., 2006, Dorus et al., 2006, Tripoli et al., 2005, Doumanis et al., 2009, Wasbrough et al., 2010, Japanese National Institute of Genetics, 2012.5.21, Malone et al., 2012) CG8189 (Metta et al., 2006, Porcelli et al., 2007, Keleman et al., 2009.8.5, Perkins et al., 2009, Cammarato et al., 2011)
Name Synonym	ATP synthase, b (Tan et al., 2009) ATP synthase, subunit b (Cammarato et al., 2011) ATP synthase B chain (Tripoli et al., 2005) ATP synthase B chain, mt precursor (Pedersen et al., 2010) F0/F1 ATP synthase B (Porcelli et al., 2007) Fo-ATP synthase subunit b (Caggese, 1996.10.21)
Secondary FlyBase IDs
References ( 36 )
Generate a list of	All references relating to this gene ( 36 )
List References by type	Research paper  ( 9 ) Supplementary material  ( 9 ) Personal communication to FlyBase  ( 9 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Curated genome annotation  ( 3 ) Protein sequence record  ( 1 ) Website  ( 1 )
Recent research papers ( 1 )
	Malone et al., 2012, Genome Biol. 13(4): r28 Mediation of Drosophila autosomal dosage effects and compensation by network interactions. [FBrf0219684] Show all research papers ...