FlyBase Gene Report: Dmel\lncRNA:roX1

General Information

Symbol

Dmel\lncRNA:roX1

Species

D. melanogaster

Name

long non-coding RNA on the X 1

Annotation Symbol

CR32777

Feature Type

lncRNA_gene

FlyBase ID

FBgn0019661

Gene Model Status

Current

Stock Availability

9 publicly available

Gene Summary

X chomosome associated RNA - chromatin associated non-translated RNA involved in dosage compensation - ectopically expressed roX1 and roX2 RNAs target high-affinity sites on the X chromosome in trans and, via spatial proximity, induce spreading of the MSL complex in cis, leading to increased expression of neighboring autosomal genes - The MSL complex regulates nucleosome positioning at high-affinity sites, therefore acting locally rather than influencing the overall chromosomal architecture. (Interactive Fly, lncRNA:roX1 )

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

roX1, roX, RNA on the X 1, yang, RNA on the X1

Key Links

Genomic Location

Cytogenetic map

3F3-3F3

Sequence location

X:3,857,230..3,862,697 [-]

Recombination map

1-5

RefSeq locus

NC_004354 REGION:3857230..3862697

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (5 terms)

Molecular Function (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in chromatin organization

inferred from genetic interaction with FLYBASE:lncRNA:roX2; FB:FBgn0019660

(Deng et al., 2009)

involved_in dosage compensation by hyperactivation of X chromosome

inferred from mutant phenotype

(Kim et al., 2018)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

part_of MSL complex

inferred from direct assay

(Babosha et al., 2023, Kim et al., 2018, Franke and Baker, 1999)

inferred from direct assay

(Meller et al., 2000)

part_of X chromosome located dosage compensation complex, transcription activating

inferred from direct assay

(Meller et al., 2000)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

part_of dosage compensation complex

inferred from electronic annotation with Rfam:RF01667

(RNAcentral, 2018-)

Gene Group (FlyBase)

MALE SPECIFIC LETHAL COMPLEX

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

MALE SPECIFIC LETHAL COMPLEX -: The Male Specific Lethal (MSL) complex is a chromatin modifying complex composed of five protein subunits and two non-coding RNAs. MSL is involved in X chromosome dosage compensation in males. (Adapted from FBrf0228243).

Summary (Interactive Fly)

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\lncRNA:roX1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.48

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.56

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

FBtr0070634

3758

FBtr0070635

3460

FBtr0337066

4421

FBtr0337067

3785

FBtr0345714

4832

Additional Transcript Data and Comments

Reported size (kB)

3.7 (northern blot)

(Amrein and Axel, 1997)

3.8, 3.6 (northern blot)

(Meller et al., 1997)

Comments

External Data

Crossreferences

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\lncRNA:roX1 using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.59

Transcript Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | male

(Meller et al., 1997)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage | male

cell

• X chromosome

Comment: expression is male-specific

(Franke and Baker, 1999)

cell

• nucleus | punctate

Comment: expression is male-specific

(Franke and Baker, 1999)

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 5

organism

• nucleus | basal

(Lecuyer et al., 2007)

embryonic stage 4 -- 6

anterior endoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

organism

Comment: rapidly degraded

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

posterior ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

yolk

(Fisher et al., 2012)

yolk nucleus

(Fisher et al., 2012)

embryonic stage 5 -- 13

embryonic brain

Comment: female embryo

(Meller et al., 1997)

larval ventral nerve cord

Comment: female embryo

(Meller et al., 1997)

embryonic stage 5 -- 17

larval ventral nerve cord

Comment: male embryo

(Meller et al., 1997)

embryonic brain

Comment: male embryo

(Meller et al., 1997)

embryonic stage 7 -- 8

antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal ectoderm

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

ventral nerve cord primordium

Comment: reported as ventral nerve cord anlage

(Fisher et al., 2012)

embryonic stage 9 -- 10

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 11 -- 12

central brain primordium

(Fisher et al., 2012)

dorsal epidermis primordium

(Fisher et al., 2012)

embryonic central brain glial cell

(Fisher et al., 2012)

embryonic optic lobe primordium

(Fisher et al., 2012)

procephalic neuroblast

(Fisher et al., 2012)

ventral epidermis primordium

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

embryonic central brain glial cell

(Fisher et al., 2012)

larval nervous system

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

third instar larval stage

embryonic/larval salivary gland

(Meller et al., 1997)

gastric caecum

(Meller et al., 1997)

ring gland

(Meller et al., 1997)

embryonic/larval garland cell

(Meller et al., 1997)

spermatogenesis & adult stage

male reproductive system

(Meller et al., 1997)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | male

organism

(Bai et al., 2004)

Additional Descriptive Data

roX1 transcript is detected in the nuclei of all body parts, and is associated with the X chromosome. In embryos, roX1 transcript colocalizes exactly with msl-1 protein.

(Franke and Baker, 1999)

In adult males, roX1 transcripts are expressed in the cell bodies of the central brain and mushroom bodies, the neurons of the optic lobe, and the interneurons of the antennal lobes. They are also expressed in peripheral neurons including the photoreceptor cells and the olfactory neurons of the third antennal segment. Strong expression is observed in the thoracic ganglia and weak expression is seen in the gut. Expression appears to be confined to the nucleus. No expression is observed in females.

(Amrein and Axel, 1997)

In cryosections of adults, roX1 transcription is strongest in the central nervous system of the male brain. Most cells of the brain and thoracic ganglia stain strongly. Weaker expression is observed in the gut, parts of the reproductive tract (especially the ejaculatory bulb), and in fat cells. In embryos, roX1 transcripts are expressed in both sexes starting at about 2.5 hours after egg laying. Expression is strong in cells of the CNS until ~stage 13 at which point the expression in females subsides. The staining disappears first from the ventral nerve cord and then from the brain. In male larvae, strong staining is seen in many tissues, including the large polyploid cells of the gastric caecae, the ring gland and the nephrocytes, and the salivary glands. This staining is nuclear and localizes to the X chromosome. roX1 expression is controlled by the dosage compensation pathway and not by tra.

(Meller et al., 1997)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of MSL complex

inferred from direct assay

(Babosha et al., 2023, Kim et al., 2018, Franke and Baker, 1999)

inferred from direct assay

(Meller et al., 2000)

part_of X chromosome located dosage compensation complex, transcription activating

inferred from direct assay

(Meller et al., 2000)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\lncRNA:roX1 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\lncRNA:roX1

View exonic expression by tissue for Dmel\lncRNA:roX1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0019661

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

3772376/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0019661

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0019661

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CR32777

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\lncRNA:roX1

Stages(s) 4-6
Stages(s) 7-8
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 27 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 46 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of lncRNA:roX1

Transgenic constructs containing regulatory region of lncRNA:roX1

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene partially disrupted in

Df(1)roX1^VM18A

(Menon et al., 2014)

Inferred from location ( 9 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

lncRNA:roX1^MB710

viable

Sterility

Allele

fertile

lncRNA:roX1^MB710

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (0)

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (0)

Mus musculus (laboratory mouse) (0)

Xenopus tropicalis (Western clawed frog) (0)

Danio rerio (Zebrafish) (0)

Caenorhabditis elegans (Nematode, roundworm) (0)

Anopheles gambiae (African malaria mosquito) (0)

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:lncRNA:roX1. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

RNA-protein

Physical Interaction

Assay

References

lncRNA:roX1 - Clamp

pull down, western blot

(Quinn et al., 2014)

lncRNA:roX1 - Unr

anti bait coimmunoprecipitation, quantitative reverse transcription pcr

(Patalano et al., 2009)

lncRNA:roX1 - mle

anti tag coimmunoprecipitation, full identification by RNA sequencing, nucleic acid uv cross-linking assay, anti bait coimmunoprecipitation, full identification by DNA sequencing, proximity ligation assay, fluorescence microscopy, pull down, western blot, clip, quantitative reverse transcription pcr

(Müller et al., 2020, Valsecchi et al., 2018, Lindehell et al., 2015, Quinn et al., 2014, Ilik et al., 2013, Maenner et al., 2013)

lncRNA:roX1 - mof

anti tag coimmunoprecipitation, northern blot

(Mendjan et al., 2006)

lncRNA:roX1 - msl-2

nucleic acid uv cross-linking assay, anti bait coimmunoprecipitation, full identification by DNA sequencing, anti tag coimmunoprecipitation, quantitative reverse transcription pcr, clip

(Valsecchi et al., 2018, Ilik et al., 2013, Li et al., 2008)

lncRNA:roX1 - msl-3

pull down, western blot, anti tag coimmunoprecipitation, northern blot

(Quinn et al., 2014, Mendjan et al., 2006)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

lncRNA:roX1

enhanceable

AGO2

(Menon and Meller, 2012)

lncRNA:roX1

enhanceable

Dcr-2

(Menon and Meller, 2012)

lncRNA:roX1

enhanceable

dop

(Menon and Meller, 2012)

lncRNA:roX1

enhanceable

Elp1

(Menon and Meller, 2012)

lncRNA:roX1

suppressible

lncRNA:roX1::Dpse\roX1

(Kelley et al., 2008)

lncRNA:roX1

suppressible

lncRNA:roX2

(Ramírez et al., 2015, Meller and Rattner, 2002)

lncRNA:roX1

enhanceable

loqs

(Menon and Meller, 2012)

lncRNA:roX1

enhanceable

msl-1

(Prabhakaran and Kelley, 2012)

suppressible

(Oh et al., 2003)

enhanceable

(Oh et al., 2003)

suppressible

(Deng et al., 2005)

lncRNA:roX1|msl-1

suppressible

ocm

(Lim and Kelley, 2013)

lncRNA:roX1

enhanceable

Spt5

(Prabhakaran and Kelley, 2012)

lncRNA:roX1

enhanceable

Su(Tpl)

(Prabhakaran and Kelley, 2012)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Bai et al., 2007)

enhanceable

(Deng et al., 2005)

msl-2

suppressible

lncRNA:roX1

(Lim and Kelley, 2012, Meller and Rattner, 2002)

msl-2|Polr2A

suppressible

lncRNA:roX1

(Meller and Rattner, 2002)

msl-2|msl-1

suppressible

Polr2A|lncRNA:roX1

(Deng et al., 2005)

msl-2|msl-1

suppressible

lncRNA:roX1

(Deng et al., 2005)

sisA|sc

enhanceable

lncRNA:roX1

(Gladstein et al., 2010)

suppressible

lncRNA:roX1

(Park et al., 2002)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

533973

DroID - A comprehensive database of gene and protein interactions.

FBgn0019661

MIST (genetic) - An integrated Molecular Interaction Database

3772376

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

lncRNA_gene

nuclear_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-5

Cytogenetic map

3F3-3F3

Sequence location

X:3,857,230..3,862,697 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

3F3-3F3

Limits computationally determined from genome sequence between P{EP}EP1200^EP1200&P{EP}EP1343 and P{EP}CG2930^EP1352

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

3F-3F

(Amrein, 1997.1.21, Meller, 1997.4.10, Meller et al., 1996)

3F-3F

(determined by in situ hybridisation)

(Amrein and Axel, 1997)

Experimentally Determined Recombination Data

Location

1-5

(FlyBase, 2016)

1-4.6

(Comeron et al., 2012)

(Meller et al., 1996)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (9)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

43648

lncRNA:roX1^ex84A

33535

w^* P{EP}lncRNA:roX1^G958

27734

y¹ v¹; P{TRiP.JF02818}attP2

31602

y¹ v¹; P{TRiP.JF01191}attP2

44848

y¹ w^* Mi{MIC}lncRNA:roX1^MI01457

35274

y¹ sc^* v¹ sev²¹; P{TRiP.GL00172}attP2

Korea

11332

P{EP}lncRNA:roX1^G10574

11344

P{EP}lncRNA:roX1^G10644

NIG-Fly

GL00172

y¹ sc^* v¹ sev²¹; P{TRiP.GL00172}attP2

Genomic Clones (17)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (271)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GH10432

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0019661

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0019661

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Transcription of the roX1 gene is directly regulated by the DNaseI hypersensitive site (DHS) within the roX1 transcription unit. This regulation requires the msl-1, msl-2, msl-3 and mle proteins but not roX (roX1 and roX2) RNAs. The DHS is not required for initiation of cis spreading of the MSL complex.

(Bai et al., 2004)

msl-2 protein controls male-specific transcription of roX1 and does not require any other MSL protein for this role.

(Rattner and Meller, 2004)

New annotation (CR32777) in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

roX1 and roX2 produce redundant transcripts required for the targeting of the MSL complex.

(Meller and Rattner, 2002)

The "roX1 chromatin entry site" (roX1-CES) is a region within the roX1 gene that is able to recruit the MSL complex. A 217bp fragment is sufficient for recruitment and spreading of the MSL complex along the flanking chromatin. This short element is sufficient to activate MSL spreading in the absence of active roX1 transcription.

(Kageyama et al., 2001)

roX1 and roX2 RNAs are required for the association of male-specific lethal (MSL) proteins with the male X chromosome.

(Franke and Baker, 1999)

roX1 and roX2 RNAs are redundant and may have a direct function in dosage compensation.

(Franke and Baker, 1999)

The roX1 gene contains sequences that seem to provide an entry site for the MSL complex to recognize the X chromosome. This site is termed the "roX1 chromatin entry site" (roX1-CES). The roX1-CES provides a nucleation site for extensive spreading (in cis or trans) of the complex into flanking chromatin, even when moved to an autosome.

(Kelley et al., 1999)

roX1 encodes an RNA with no apparent reading frame that shows male-specific expression in the adult fly, and is regulated by genes of the dosage compensation pathway. It is closely linked to yin, a female-specific gene expressed in the ovary.

(Amrein and Axel, 1997)

The roX1 gene shows a male-specific expression pattern in adult flies, localising specifically to the male X chromosome. roX1 expression is dependent on Sxl, but is independent of tra activity, and is positively regulated by genes of the dosage compensation system such as mle.

(Meller et al., 1997)

Relationship to Other Genes

Source for database merge of

Source for merge of: roX1 BcDNA:GH10432

(FlyBase, 1996-)

Additional comments

Source for merge of roX1 BcDNA:GH10432 was a shared cDNA ( date:030728 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: lncRNA:roX1 roX1

(FlyBase, 2009-)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (18)

Reported As

Symbol Synonym

BcDNA:GH10432

CR32777

(Ni et al., 2011.7.19, Mosallanejad et al., 2010, Lebo et al., 2009, Perkins et al., 2009, Hutter, 2008.12.10, Ni et al., 2008, Biemar et al., 2006)

EG:EG0002.2

FBgn0019661

(Ko et al., 2023)

RoX1

(Lee et al., 2014)

chrX:3706836..3706970

(Will et al., 2013)

lncRNA-roX1

(Li et al., 2019)

lncRNA:roX1

(Dayal Aggarwal et al., 2024, Zhang et al., 2023, Everetts et al., 2021, Xu et al., 2019)

roX

(Bhardwaj et al., 2019, Keller and Akhtar, 2015, Maenner et al., 2012, de la Cruz et al., 2005, Nusinow and Panning, 2005, Brehm et al., 2004, Carrozza et al., 2003, Arndt-Jovin et al., 2001, Scott et al., 2000, Kuroda, 1998, Panning and Jaenisch, 1998, Kuroda and Meller, 1997)

roX1

(Tikhonova et al., 2024, Chan et al., 2023, Jalloh et al., 2023, Lu et al., 2023, Majane et al., 2022, Zhou et al., 2022, Aleman et al., 2021, Higareda Alvear et al., 2021, Lauria Sneideman and Meller, 2021, Makki and Meller, 2021, Ota et al., 2021, Valsecchi et al., 2021, Witt et al., 2021, Ellison and Bachtrog, 2019, Kopp and Park, 2019, Li et al., 2019, Lv et al., 2019, Prayitno et al., 2019, Tikhonova et al., 2019, Bell et al., 2018, Cheetham and Brand, 2018, Kim et al., 2018, Lucchesi, 2018, Valsecchi et al., 2018, Ilik et al., 2017, Joshi and Meller, 2017, Liu et al., 2017, Rogoyski et al., 2017, Urban et al., 2017, Kuroda et al., 2016, Kuzu et al., 2016, Quinn et al., 2016, Gallach, 2015, Koya and Meller, 2015, Lakhotia, 2015, Lindehell et al., 2015, Lucchesi and Kuroda, 2015, Ramírez et al., 2015, Ríos-Barrera et al., 2015, Vensko and Stone, 2015, Apte et al., 2014, Ferrari et al., 2014, Figueiredo et al., 2014, Lee et al., 2014, Menon et al., 2014, Militti et al., 2014, Quinn et al., 2014, Stern et al., 2014, Chen et al., 2013, Ilik et al., 2013, Lim and Kelley, 2013, Lundberg et al., 2013, Philip and Stenberg, 2013, Soruco et al., 2013, Vicoso and Bachtrog, 2013, Larschan et al., 2012, Lim and Kelley, 2012, Menon and Meller, 2012, Prabhakaran and Kelley, 2012, Birchler et al., 2011, Georgiev et al., 2011, Larschan et al., 2011, Morra et al., 2011, Straub and Becker, 2011, Gallach et al., 2010, Gladstein et al., 2010, Park et al., 2010, Prabhakaran and Kelley, 2010, Deng and Meller, 2009, Deng et al., 2009, Hutter, 2009.5.17, Hutter, 2009.6.2, Lebo et al., 2009, Menon and Meller, 2009, Patalano et al., 2009, Alekseyenko et al., 2008, Aratani et al., 2008, Bachtrog, 2008, Hutter, 2008.12.10, Kelley et al., 2008, Kong and Meller, 2008, Li et al., 2008, Morra et al., 2008, Park et al., 2008, Pierre et al., 2008, Semeshin et al., 2008, Spierer et al., 2008, Sural et al., 2008, Bai et al., 2007, Copeland et al., 2007, Larschan et al., 2007, Larschan et al., 2007, Lecuyer et al., 2007, Mendjan and Akhtar, 2007, Park et al., 2007, Prasanth and Spector, 2007, Stark et al., 2007, Straub and Becker, 2007, Biemar et al., 2006, Buscaino et al., 2006, Dahlsveen et al., 2006, Deng and Meller, 2006, Deng and Meller, 2006, Gilfillan et al., 2006, Legube et al., 2006, Mendjan et al., 2006, Pal Bhadra et al., 2006, Schubeler, 2006, Deng et al., 2005, Inagaki et al., 2005, Ray and Fox, 2005, Zhimulev et al., 2003)

rox-1

(Erickson, 2016)

rox1

(Peterson et al., 2021, Furuhashi et al., 2006, Gim et al., 2001, Franke and Baker, 2000, Mahesh and Ranganath, 2000, Franke and Baker, 1999)

Name Synonyms

RNA on the X 1

(Georgiev et al., 2011, Morra et al., 2011, Lebo et al., 2009, Deng and Meller, 2006, Meller et al., 1997)

RNA on the X chromosome 1

(Prabhakaran and Kelley, 2010)

RNA on the X1

(Menon and Meller, 2009, Aratani et al., 2008)

RNAonX

(Gim et al., 2001)

long non-coding RNA on the X 1

yang

(Meller et al., 1995, Wu et al., 1995)

Secondary FlyBase IDs

FBgn0015564
FBgn0052777
FBgn0063259

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 36 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

3772376

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

RNAcentral - A comprehensive ncRNA sequence collection representing all ncRNA types from a broad range of organisms

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0019661

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

3772376/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0019661

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0019661

FlyMine - An integrated database for Drosophila genomics

FBgn0019661

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CR32777

MARRVEL_MODEL - MARRVEL (model organism gene)

3772376

Linkouts

BioGRID - A database of protein and genetic interactions.

533973

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0019661

DroID - A comprehensive database of gene and protein interactions.

FBgn0019661

DRSC - Results frm RNAi screens

FBgn0019661

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0019661

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CR32777

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (genetic) - An integrated Molecular Interaction Database

3772376

References (275)

The following external sites may use different assemblies or annotations than FlyBase.

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